Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| resolution of the african hominoid trichotomy by use of a mitochondrial gene sequence. | mitochondrial dna sequences encoding the cytochrome oxidase subunit ii gene have been determined for five primate species, siamang (hylobates syndactylus), lowland gorilla (gorilla gorilla), pygmy chimpanzee (pan paniscus), crab-eating macaque (macaca fascicularis), and green monkey (cercopithecus aethiops), and compared with published sequences of other primate and nonprimate species. comparisons of cytochrome oxidase subunit ii gene sequences provide clear-cut evidence from the mitochondrial g ... | 1991 | 1996358 |
| gustatory neural coding in the monkey cortex: stimulus intensity. | 1. we analyzed the activity of single neurons in gustatory cortex of alert cynomolgus monkeys in response to a range of stimulus intensities. chemicals were deionized water, fruit juice, and several concentrations of the four prototypical taste stimuli: 10(-3)-1.0 m glucose, 10(-3)-1.0 m nacl, 10(-4)-3 x 10(-2) m hcl, and 10(-5)-3 x 10(-3) m quinine hcl. 2. taste-evoked responses could be recorded from a cortical gustatory area that measured 2.5 mm in its anteroposterior extent, 6.0 mm dorsovent ... | 1991 | 1999734 |
| the thyroid hormone analogue skf-94901 and iodothyronine binding sites in mammalian tissues: differences in cytoplasmic binding between liver and heart. | the thyroid hormone analogue, skf-94901 exhibits greater thyromimetic activity in the liver than in the heart. this difference in activity may reflect heterogeneity in the affinity of skf-94901 for different forms of the t3 receptor. a difference in extranuclear transport of the analogue could also account for the different response of these two tissues. to distinguish between these possibilities we have examined the binding of skf-94901 to membrane, cytosolic and nuclear preparations from liver ... | 1991 | 2000700 |
| testosterone regulates pro-opiomelanocortin gene expression in the primate brain. | endogenous opioid peptides such as beta-endorphin, derived from proopiomelanocortin (pomc), have been widely implicated as serving an important role in the neuroendocrine regulation of the primate reproductive axis. in both human and nonhuman primates, pomc neurons are thought to mediate, at least in part, the negative feedback action of sex steroids on gnrh. sex steroids, such as testosterone, are thought to inhibit gnrh secretion by enhancing the inhibitory activity of beta-endorphin; however, ... | 1991 | 2004607 |
| inhibition of peripheral aromatization in the male cynomolgus monkey by a novel nonsteroidal aromatase inhibitor (r 76713). | r 76713 (6-[(4-chlorophenyl)(1-h-1,2,4-trizol-1-yl)methyl]1-h benzotriazole) is a highly potent and selective inhibitor of the aromatase enzyme both in vitro and in vivo. the ability of r 76713 to inhibit peripheral aromatization of androstenedione (a) to estrone (e1) in vivo was studied in male cynomolgus monkeys (macaca fascicularis). peripheral aromatization was measured using a primed constant infusion of [3h] a and [14c]e1 for 3.5 h. blood samples, collected during the final hour of infusio ... | 1991 | 2005200 |
| transplantation of vascularized composite mandibular allografts in young cynomolgus monkeys. | in the search for donor tissue for massive craniofacial defects, the transplantation of somatic tissue allografts was explored. four young, out-bred cynomolgus monkeys were the recipients of orthotopic hemimandibular allotransplants from nonrelated cynomolgus monkeys. the transplant consisted of one-half of the mandible with attached muscle, skin, and mucosa. cyclosporine 15 mg/kg/day was given subcutaneously each day. the 4 monkeys were observed for 13, 27, 63, and 65 days, respectively. all tr ... | 1991 | 2006838 |
| [the effect of a high-intensity radiation exposure on the brain function of monkeys. the postradiation changes in brain bioelectrical activity]. | in experiments with macaca fascicularis it has been found that changes in the total bioelectric activity of the brain within the eeg range that occur during the first 60 min following whole-body irradiation with a dose of 45 gy (6.5 gy/s) are interrelated with the dynamics of nervous and psychic activity of the exposed animals, exhibit a definite stereotype of their development (disorganization of rhythms: generalized synchronization of biopotentials; and development of synchronous processes), a ... | 1991 | 2008531 |
| biotransformation of scoparone used to monitor changes in cytochrome p450 activities in primary hepatocyte cultures derived from rats, hamsters and monkeys. | the coumarin derivative scoparone is regioselectively demethylated yielding isoscopoletin and scopoletin. the ratio of the formation rates of these two metabolites (isoscopoletin/scopoletin; i/s ratio) is reported to mirror the contribution of several cytochrome p450 (p450) isoenzymes to the biotransformation of scoparine. the metabolism of scoparine has been studied in primary liver cell cultures of rats, hamsters, cynomolgus monkeys and in human liver cells. rat hepatocytes appeared to metabol ... | 1991 | 2009095 |
| periodontium response to a root canal condensing device (endotec). | two macaca (fascicularis) monkeys were used to study the effect of two warm endodontic condensation techniques (endotec and vertical condensation method) on periodontal tissues. the specimens were histologically evaluated at 3 and 32 days after the endodontic treatments were completed. in this study the periodontium was divided into coronal, middle, and apical thirds. results indicated that there was no heat-related damage to periodontal tissues from either of the two methods employed. however, ... | 1991 | 2011357 |
| immediate and delayed direct pulp capping with the use of a new visible light-cured calcium hydroxide preparation. | the pulpal response to mechanical exposure and capping either immediately or after 24 hours was investigated in 64 teeth of four cynomolgus monkeys with the use of dycal, vlc dycal, or prisma-bond. all overlying amalgam restorations were surface-sealed with zinc oxide-eugenol cement. after 2 months the teeth were removed and prepared for histologic examination; dentine bridges were present in almost all teeth filled with dycal or vlc dycal, and pulpal inflammation was observed in only one tooth ... | 1991 | 2011358 |
| anti-tac-h, a humanized antibody to the interleukin 2 receptor, prolongs primate cardiac allograft survival. | high-affinity interleukin 2 receptors (il-2rs) are expressed by t cells activated in response to foreign histocompatibility antigens but not by normal resting t cells. to exploit this difference in il-2r expression, anti-tac-m, a murine monoclonal antibody specific for the il-2r alpha chain, was used to inhibit organ allograft rejection. however, the use of murine anti-tac as an immunosuppressive agent was limited by neutralization by human anti-murine antibodies and by weak recruitment of effec ... | 1991 | 2011577 |
| synthesis of il-1 alpha and il-1 beta by arterial cells in atherosclerosis. | interleukin-1 (il-1) has been implicated as a regulatory protein in the development and clinical sequelae of atherosclerosis. to determine which cells in the atherosclerotic plaque synthesize il-1 in situ, the authors evaluated histologic sections of iliac arteries from cynomolgus monkeys using probes for il-1 alpha and beta. a polyclonal antibody to il-1 alpha and beta was used to determine if proteins were concomitantly produced. the predominant cells expressing il-1 alpha and beta mrna were f ... | 1991 | 2012178 |
| effects of atherosclerosis and regression on vascular responses to products of activated platelets in primates. | we aggregated human platelets in vitro and examined vascular responses to injection of the supernatant in atherosclerotic primates. platelets were washed, suspended, and aggregated with thrombin. thrombin was then inactivated with d-phe-pro-argch2cl, and the suspension was centrifuged. the supernatant was injected intra-arterially into the perfused hindlimb within 30 s after aggregation of platelets. we studied normal cynomolgus monkeys, atherosclerotic monkeys that were fed atherogenic diet for ... | 1991 | 2012210 |
| half-life, hemodynamic, renal, and hormonal effects of prorenin in cynomolgus monkeys. | prorenin is found in human plasma, kidneys, and reproductive organs. we investigated the physiological and pharmacokinetic properties of plasma prorenin, and its plasma conversion to active renin, by bolus infusions of human recombinant prorenin (0.5, 2, 20 micrograms; n = 4/dose) into anesthetized male cynomolgus monkeys. the infused prorenin had 3% intrinsic renin activity. plasma prorenin rose from 61 +/- 6 to 101 +/- 11, 570 +/- 46, and 7,700 +/- 390 ng.ml-1.h-1, respectively, after 5 min. p ... | 1991 | 2012251 |
| the effect on vertical tooth mobility of extraction and immediate replacement of incisors (macaca fascicularis). | intrusive displacement of 7 incisors was measured before and within 3 min of extraction. a substantial increase in intrusion with recovery from loads of 4 n followed replacement of the incisors. these changes are taken to indicate that tension is an important mechanism of support in the intact periodontal ligament. | 1991 | 2012530 |
| effects of single and multiple inhalations of antigen on airway responsiveness in monkeys. | airway hyperresponsiveness is an important and characteristic feature of asthma. in monkeys, we have reported that antigen (ag) inhalation induces a prolonged airway eosinophilia, that chronic airway eosinophilia is associated with marked airway hyperresponsiveness, and that chronic ag inhalations induce airway eosinophilia and hyperresponsiveness. in this study we have determined the effects of acute ag inhalation(s) on airway responsiveness to obtain a protocol for the study of the mechanisms ... | 1991 | 2013678 |
| precipitation of the renin inhibitor ditekiren upon i.v. infusion; in vitro studies and their relationship to in vivo precipitation in the cynomolgus monkey. | ditekiren is a pseudo-octapeptide being developed as an inhibitor of human renin. preclinical drug safety studies with this drug involved continuous i.v. infusions through indwelling catheters in the right internal jugular vein of the cynomolgus monkey for up to 30 days. the following physiocochemical properties of ditekiren make it susceptible to intravascular precipitation immediately following iv infusion: (1) the water solubility of ditekiren is high at acidic ph where the drug is formulated ... | 1991 | 2014212 |
| localization of androgen receptor in the follicle and corpus luteum of the primate ovary during the menstrual cycle. | ovarian androgens may act locally to modulate follicular and luteal function in various species. this study examined the distribution of androgen receptors within the primate ovary throughout the menstrual cycle. ovaries were collected from rhesus and cynomolgus monkeys during the early, mid-, and late (n = 3-5 per stage) follicular and luteal phases of the cycle. the tissues were processed for indirect immunocytochemical localization of androgen receptors with a specific monoclonal antibody aga ... | 1991 | 2015374 |
| pericyte changes in branch retinal vein occlusion. | the model of experimental branch vein occlusion (bvo) in the monkey offers the opportunity to examine retinal capillaries under stress. electron microscopic morphometry was done on 812 capillaries of 13 eyes of cynomolgus monkeys, comparing 579 capillary collaterals of 9 bvo eyes with 233 normal capillaries of 4 control eyes. the tissue underwent the myosin subfragment-1 technique to decorate and quantify bundles of actin filaments in capillary pericytes. the duration of bvo was 2-48 months. cap ... | 1991 | 2016128 |
| experimental ocular onchocerciasis in cynomolgus monkeys. iv. chorioretinitis elicited by onchocerca volvulus microfilariae. | onchocerciasis is a major cause of blindness worldwide, and much of the blindness is caused by onchocercal chorioretinitis. in an experimental animal model for ocular onchocerciasis, intravitreal injections of 10,000 live onchocerca volvulus microfilariae isolated from infected humans into the eyes of cynomolgus monkeys (macaca fascicularis) resulted in patchy, progressive loss of retinal pigment with pigment clumping. areas of pigment loss were less extensive in animals that had been sensitized ... | 1991 | 2016131 |
| cytochalasin b potentiates epinephrine's outflow facility-increasing effect. | total outflow facility was determined in both eyes of cynomolgus monkeys by two-level constant pressure perfusion. after a baseline measurement, one eye of the experimental animal received intracameral cytochalasin b (cb); the other eye received vehicle without cb. twenty minutes later both eyes received intracameral epinephrine (epi), and 30 min later the outflow facility was again determined. doses of cb and epi which were subthreshold when given singly produced significant facility increases ... | 1991 | 2016142 |
| antiviral effects of 3'-fluorothymidine and 3'-azidothymidine in cynomolgus monkeys infected with simian immunodeficiency virus. | an acute infection with simian immunodeficiency virus (sivsm) in cynomolgus monkeys was used to evaluate the antiviral effects of 3'-fluorothymidine (flt) and 3'-azidothymidine [zidovudine (zdv)]. neither compound prevented the infection despite dosing prior to virus inoculation. flt was about ten times more potent than zdv in delaying the appearance of sivsm antigen in the monkeys. the serum half-life of flt was longer than that of zdv and zdv was bound to plasma proteins to about 60% while flt ... | 1991 | 2016686 |
| endothelial dysfunction in response to psychosocial stress in monkeys. | the current study was designed to evaluate the effects of a disrupted social environment on the endothelial integrity of various vascular segments in male cynomolgus monkeys (macaca fascicularis). each of 20 single-caged adult monkeys was fed a diet comparable to a person's ingestion of 240 mg cholesterol/day for a 10-week baseline period and then was introduced as a stranger into a four-member social group for 3 days. half of the monkeys received a beta-adrenergic blocking agent (metoprolol) vi ... | 1991 | 2018991 |
| developmental toxicity of l-selenomethionine in macaca fascicularis. | forty pregnant long-tailed macaques were dosed via nasogastric intubation with 0, 25, 150, or 300 micrograms/kg of l-selenomethionine (se) daily during organogenesis [gestational day (gd) 20-50]. clinical examination of the dams, maternal body weights, sonographic evaluations, clinical chemistry screens, and measures of serum progesterone and urinary estrone conjugates were used as indicators of maternal and fetal status in all animals. the pregnancies of two to three dams from each dose group w ... | 1991 | 2019339 |
| anatomic correlates of aortic pulse wave velocity and carotid artery elasticity during atherosclerosis progression and regression in monkeys. | we noninvasively measured changes in average aortic stiffness in 79 cynomolgus monkeys being fed cholesterol progression, regression, and control diets by measuring pulse wave velocity (pwv) in 260 experiments during a 30-month period. every 6 months, a group of monkeys was studied with invasive aortic pwv techniques and with ultrasonically determined pressure-strain elastic modulus (ep) of the carotid artery, and then the group was killed so that morphometric evaluation of atherosclerosis sever ... | 1991 | 2022028 |
| plasma lipid transfer protein as a determinant of the atherogenicity of monkey plasma lipoproteins. | this study was undertaken to determine potential tissue sources of plasma cholesteryl ester transfer protein (cetp), and to assess the influence of cetp on lipoprotein concentrations and atherosclerosis. in a group of 28 cynomolgus monkeys fed high fat, high cholesterol diets, plasma cetp concentration was strongly correlated with the abundance of cetp mrna in liver and in adipose tissue, and with the output of cetp in liver perfusates. plasma cetp concentration showed a strong inverse correlati ... | 1991 | 2022728 |
| evaluation of the onset and duration of response to cold air inhalation challenge in cynomolgus monkeys (macaca fascicularis). | cold air inhalation challenge (caic) for the evaluation of bronchial reactivity has been proposed as a physical agent alternative to chemical agent challenges (methacholine or histamine), especially suitable for the occupational environment. the present investigation describes and evaluates a method for performing cold air inhalation challenge in cynomolgus monkeys (macaca fascicularis), a species shown to be useful in animal modeling studies of occupational asthma. six adult male anesthetized m ... | 1991 | 2022812 |
| displacement of the optic nerve head by acute changes in intraocular pressure in monkey eyes. | the authors used the humphrey retinal analyzer to study the effect of acute changes in intraocular pressure (iop) on the topography of the optic nerve head in normotensive and hypertensive eyes of cynomolgus monkeys. chronically elevated iop was produced monocularly in monkeys by argon laser angle treatment. in 8 hypertensive eyes, the mean iop of 51 mmhg was lowered acutely to 15 mmhg with a needle placed in the anterior chamber. in 12 normotensive eyes, the mean iop of 16 mmhg was similarly in ... | 1991 | 2023730 |
| clinicopathologic correlation of diode laser burns in monkeys. | one hundred twenty-five retinochoroidal photocoagulation burns, produced by a transpupillary diode laser (810 nm) in six eyes of three cynomolgus monkeys, were evaluated by clinicopathologic correlation for up to 9 weeks after laser treatment. diode burns of clinical grade 2 strength were comparable to those described for argon laser. however, diode burns of clinical grade 3 strength produced choroidal changes more intense than those described for argon laser. where present underneath photocoagu ... | 1991 | 2025166 |
| distribution of choline acetyltransferase-immunoreactive axons in monkey frontal cortex. | cholinergic neurons of the nucleus basalis of meynert project to numerous regions of the cerebral cortex. however, little is known about the regional and laminar distributions of cholinergic axons in monkey frontal cortex. in this study, immunohistochemical techniques were used to identify axons that were immunoreactive for choline acetyltransferase, the enzyme that catalyses the synthesis of acetylcholine, in the frontal cortex of cynomolgus monkeys. motor cortex contained the greatest density ... | 1991 | 2027466 |
| long-term cholesterol feeding alters the reactivity of primate coronary microvessels to platelet products. | hypercholesterolemia impairs endothelium-dependent relaxations to several platelet-derived substances in large vessels. the effect of hypercholesterolemia on the response of coronary microvessels to platelet products and thrombin is less well defined. three groups of cynomolgus monkeys were studied: normal (n = 6), short-term hypercholesterolemic (8-11 weeks, n = 5), and long-term hypercholesterolemic (18-80 months, n = 6). responses of coronary microvessels, 100-200 microns in diameter, to thro ... | 1991 | 2029502 |
| similar patterns of dna adduct formation of 2-amino-3-methylimidazo [4,5-f]quinoline in the fischer 344 rat, cdf1 mouse, cynomolgus monkey and salmonella typhimurium. | 2-amino-3-methylimidazo [4,5-f]quinoline (iq) is a known liver carcinogen in the fischer 344 rat, the cdf1 mouse and in the cynomolgus monkey. using 32p-postlabeling assays, we compared iq-dna adduct formation in the liver of iq-treated fischer 344 rats, cdf1 mice and cynomolgus monkeys with that in salmonella typhimurium (strain ta98) incubated with iq (in the presence of a liver s9 activating system) or n-hydroxy-iq. up to five adducts could be detected, the pattern of which was identical in a ... | 1991 | 2029759 |
| pharmacokinetic and pharmacodynamic analysis of a human immunoglobulin m monoclonal antibody in neonatal macaca fascicularis. | we have developed a human mab that opsonizes group b streptococci, the major cause of gram-positive bacterial sepsis in newborns. it is an igm class human mab that possess unique protective activity against experimental infections caused by the predominant group b capsule serotypes iii and i. preliminary preclinical studies with the igm human mab were designed to provide initial information useful for predicting its safety and pharmacokinetic properties. two neonatal macaca fascicularis monkeys ... | 1991 | 2034481 |
| [effect of a high-intensity radiation exposure on brain function in monkeys. postradiation changes in central coordination of brain bioelectrical processes]. | in experiments with macaca fascicularis exposed to high-energy electrons (45 gy, 6.5 gy/s) revealed were early changes in the coherent spectrum of eeg semihemispheric leads. these changes were displayed by the increased interrelation between slow-wave fluctuations and decreased coherence within the mid- and high-frequency eeg-rhythms band. the relationship was noted between the changes observed and the clinical symptoms features of early radiation response as well as the dynamics of the cns func ... | 1991 | 2034804 |
| beta-hydroxybutyrate: a urinary marker of imipenem induced nephrotoxicity in the cynomolgus monkey detected by high field 1h nmr spectroscopy. | the use of 1h nmr as a complement to conventional clinical chemistry and histopathology resulted in the detection of hitherto unsuspected changes in urine composition as a result of imipenem induced nephrotoxicity. large quantities of beta-hydroxybutyrate, as well as other ketone bodies were detected, indicating a disruption of energy metabolism. beta-hydroxybutyrate may provide a useful non-invasive marker for imipenem toxicity. | 1991 | 2039554 |
| effect of methylmercury on acetylcholinesterase and serum cholinesterase activity in monkeys, macaca fascicularis. | 1991 | 2039873 | |
| unit activity in the hippocampus and the parahippocampal temporobasal association cortex related to memory and complex behaviour in the awake monkey. | monkeys (macaca fascicularis) were trained on a delayed match-to-sample (dms) task using delays of upto 20 s. unit activity was recorded from the hippocampus and the temporo-basal association cortex in the lateral parahippocampal region (partly corresponding to tf and th) during the dms task, as well as during a visual object discrimination task and some behavioural situations involving the experimenter. units were encountered that gave visual responses which were sometimes context-dependent. ch ... | 1991 | 2039943 |
| antide-induced suppression of pituitary gonadotropin and ovarian steroid secretion in cynomolgus monkeys: premature luteolysis and prolonged inhibition of folliculogenesis following single treatment. | administration of high-dose antide to ovariectomized monkeys results in rapid, prolonged, and reversible inhibition of gonadotropin secretion. the present study examined whether similar long-term control would be manifested in the menstrual cycle of intact primates. antide administration at a dose of either 3.0 or 18.0 mg/kg induced rapid suppression of bioassayable lh concentrations, precipitating a concurrent fall in serum progesterone concentrations from 7.9 +/- 3.6 and 5.8 +/- 1.0 ng/ml (mea ... | 1991 | 2043741 |
| primate vascular responses to octimibate, a non-prostanoid agonist at the prostacyclin receptor. | 1. octimibate is a potent inhibitor of human platelet aggregation, and appears to act (at least in part) through the prostacyclin receptor, as described in the preceding paper. here, the vascular effects, both in vitro and in vivo, of octimibate have been compared to those of the stable prostacyclin (pgi2) mimetic, iloprost. since octimibate shows extensive species variation and is potent at inhibiting platelet aggregation in primates, all of the experiments reported here have been carried out w ... | 1991 | 2043927 |
| magnetic resonance imaging of experimental allergic encephalomyelitis in primates. | the potential use of quantitative mri to characterize early, as well as late, immune-mediated lesions of multiple sclerosis (ms) has been investigated. experimental allergic encephalomyelitis (eae) was induced in 4 male macaca fascicularis monkeys, and the development of the disease followed using quantitative mri at 0.15 tesla. serial scans were recorded daily, beginning at day 9 after inoculation. lesions were detected before the onset of clinical signs, due to an elevation in the spin-lattice ... | 1991 | 2043942 |
| [morphometrical study of physical growth of laboratory-bred cynomolgus monkeys aged from zero to 9 years]. | the relative growth was examined in laboratory-bred cynomolgus monkeys (macaca fascicularis) aged from zero to 9 years. the principal component analysis and multivariate allometry were applied to the biometrical data. as the result of the principal component analysis, the cumulative contribution ratio of the 1 st (pc 1) and 2 nd (pc 2) principal components accounted for 99.0 percent. according to the eigen vector values of each morphological site (14 sites), pc 1 was acceptable not only as a siz ... | 1991 | 2044668 |
| a study of facial growth in the sooty mangabey cercocebus atys. | this study examines the pattern of facial bone growth remodelling in the sooty mangabey (cercocebus atys) by scanning electron microscopy (sem) of high-accuracy replicas. the efficacy of the technique is appraised by sem interpretations of facial remodelling in the crab-eating macaque (macaca fascicularis) and correlative histological examination. the results indicate that the distribution of depository and resorptive areas in cercocebus closely parallels that which has been observed in macaca. ... | 1991 | 2045016 |
| assessment of abdominal fat deposition in female cynomolgus monkeys. | computed tomography (ct) was used to assess abdominal fat distribution in adult, female cynomolgus macaques (macaca fascicularis). the technique used was similar to that applied in human beings and allowed intra-abdominal, subcutaneous and total abdominal fat to be quantitated in 1 cm thick sections. correlations between single scans and the average of scans at several levels ranged from r = 0.96 to r = 1.00, indicating that a single scan is representative of abdominal fat distribution. signific ... | 1991 | 2045214 |
| effects of neuropeptide y on the in vitro release of gonadotropin-releasing hormone, luteinizing hormone, and beta-endorphin and pituitary responsiveness to gonadotropin-releasing hormone in female macaques. | the objectives of these studies were to examine the release of gonadotropin-releasing hormone (gnrh) and beta-endorphin-like activity (beta-ep) from macaque hypothalami, and the release of luteinizing hormone (lh) and gnrh-induced lh from macaque anterior pituitaries in response to neuropeptide y (npy) treatment. anterior hypothalamic (ah) and mediobasal hypothalamic (mbh) blocks of tissues and the adenohypophysis were bisected along the midline into two equal-sized fragments. fragments were sup ... | 1991 | 2046872 |
| combined effects of granulocyte-macrophage colony stimulating factor with erythropoietin in subhuman primates. | recently, we showed in a cynomolgus monkey model that the combination of interleukin-3 (il-3) and granulocyte-macrophage colony stimulating factors (gm-csf) demonstrates synergistic effects, if administered sequentially. not only were progenitor cells of the myelocytic lineage stimulated cooperatively, but platelet release was also observed. these effects could not be found using these factors alone. in this study, gm-csf was administered with erythropoietin (epo) in a sequential manner. this tr ... | 1991 | 2048558 |
| stimulatory effect of romurtide on hematopoiesis in monkeys. | repeated subcutaneous injections of romurtide (n2-[(n-acetylmuramoyl)-l-alanyl-d-isoglutaminyl]-n6-stearoyl-l-lysine, mdp-lys(l18), muroctasin; cas 78113-36-7), a synthetic muramyl dipeptide derivative, increased significantly the number of peripheral neutrophils and monocytes in a dose-dependent fashion in healthy cynomolgus monkeys (macaca fascicularis). the number of platelets was also increased significantly in monkeys with repeated dosing of romurtide. after single dosing of romurtide (1 mg ... | 1991 | 2049113 |
| contrasting properties of monkey somatosensory and motor cortex neurons activated during the control of force in precision grip. | 1. single cell activity was investigated in the precentral motor (mi) and postcentral somatosensory (si) cortex of the monkey to compare the neuronal activity related to the control of isometric force in the precision grip and to assess the participation of si in motor control. 2. three monkeys (macaca fascicularis) were trained in a visual step-tracking paradigm to generate and precisely maintain force on a transducer held between thumb and index finger. great care was taken to have the monkeys ... | 1991 | 2051196 |
| effect of a modified rectus tuck on anterior segment circulation in monkeys. | removal of a rectus muscle results in permanent interruption of blood flow in the corresponding anterior ciliary artery, predisposing to anterior segment ischemia (asi). a subhuman primate model of asi was developed in order to study a novel muscle tuck procedure designed to preserve anterior ciliary artery circulation. fluorescein angiograms were obtained before and after surgery to determine the effect of the muscle surgery on iris circulation. a total of 12 eyes from 12 cynomolgus monkeys und ... | 1991 | 2051293 |
| a primate model of macular cyst. | perfluoropropane (c3f8) was injected into nine eyes of six cynomolgus monkeys. in all nine eyes, macular changes consistent with the development of a macular cyst were noted within 3 months after injection. on fluorescein angiography, there was no evidence of retinal vascular leakage associated with the macular cysts. histopathologic evaluation of six eyes demonstrated microcystic changes throughout the perifoveal inner nuclear layer. these coalesced into larger cystic spaces in the outer plexif ... | 1991 | 2052310 |
| [histopathological study on the monkey retina and choroid by diode laser endophotocoagulation]. | the fundi of three cynomolgus monkeys were coagulated using a diode laser endophotocoagulator. the histopathological changes of the retina and the choroid were investigated periodically up to 3 months. the damage of the retina extended into the outer plexiform layer following mild burn, into the inner nuclear layer with moderate burn and into the nerve fiber layer on severe burn. the pigment epithelium proliferated with multiple layer cells 1-3 months after the irradiation. the choriocapillaries ... | 1991 | 2053522 |
| [experimental retinal branch vein occlusion]. | experimental retinal branch vein occlusion in monkeys (macaca irus) were produced by yellow wavelength (577nm) dye laser photocoagulation. the clinical sequence was observed in terms of the structural and ultrastructural findings occurring during the natural history of experimental branch vein occlusion, particularly in the early stage. immediately after the occlusion, venous dilatation and retinal edema and hemorrhage appeared. extravascular leakage of dye in fluorescein angiography and hemorrh ... | 1991 | 2053523 |
| effects of chronic caffeine consumption in pregnant monkeys (macaca fascicularis) on blood and urine clinical chemistry parameters. | pregnancy requires a variety of physiological adaptations to create an environment for the optimal development of the fetus. the widespread consumption of the methylxanthines especially caffeine and to a lesser extent theophylline by pregnant women suggests that it is important to determine whether these methylxanthines may influence maternal physiology during pregnancy. forty female monkeys (macaca fascicularis), randomly divided into three groups, were exposed to caffeine in their drinking wat ... | 1991 | 2055360 |
| cytotoxic t-cell response to simian immunodeficiency virus by cynomolgus macaque monkeys immunized with recombinant vaccinia virus. | simian immunodeficiency virus (siv) gag-specific major histocompatibility complex (mhc)-restricted cytotoxic t-lymphocyte (ctl) activity was elicited in four out of six cynomolgus macaques after two immunizations with siv gag recombinant vaccinia virus (rvv). no activity could be seen in three out of three non-immunized control animals. low levels of anti-gag antibody were also seen in the same four responding animals. virus-specific, mhc-restricted ctl are thought to give some protection and to ... | 1991 | 2059372 |
| simian immunodeficiency virus (sivsm) isolation from blood and brain of experimentally infected macaques. | the possibility of using simian immunodeficiency virus (siv)-infected macaques to study pathogenic events linked to hiv infection of the brain prompted us to investigate some of the virological features in siv-infected macaques. nine cynomolgus macaques were inoculated with sivsm and killed at different times. we successfully isolated virus from the blood of all the animals and from the brains of eight. these results point to the early and regular spread of this lentivirus to the brain. neutrali ... | 1991 | 2059387 |
| determinants controlling iatrogenic external root resorption and repair during and after palatal expansion. | the mechanisms controlling iatrogenic external root resorption (err) and repair were studied on 8 macaca fascicularis monkeys. the animals were divided into short-term and long-term groups, and were treated with jackscrew, magnetic and sham palatal expansion appliances. scanning electron microscopy morphometric analysis found major evidence of err in the tooth-borne jackscrew appliance, in the long-term group, in the maxillary premolars, on the buccal and furcation root surfaces, on the mesiobuc ... | 1991 | 2064069 |
| function of the supraorbital region of primates. | the purpose of this study was to test the hypothesis that the functional significance of well-developed brow-ridges in primates is to counter powerful masticatory forces during chewing and biting. this was done by measuring and analysing patterns of in vivo bone strain recorded from rosette strain gauges bonded to the supraorbital region of macaca fascicularis (the crab-eating or long-tailed monkey) and papio anubis (the olive baboon) during mastication and incision. it was found that the suprao ... | 1991 | 2064549 |
| vaccine protection against hiv-2 infection in cynomolgus monkeys. | the aim of this study was to determine if protection against an infectious human immunodeficiency virus type 2 (hiv-2) challenge could be obtained in cynomolgus macaques by active immunization using whole killed virus vaccine. four monkeys were immunized with killed hiv-2sbl-6669, two of them with five intramuscular (im) injections of viral preparation containing 100 or 300 micrograms protein emulsified in incomplete freund's adjuvant (ifa) and the two remaining received four im injections of 25 ... | 1991 | 2064826 |
| studies on the effect of dietary fish oil on the physical and chemical properties of low density lipoproteins in cynomolgus monkeys. | to determine the effect of isocaloric substitution of dietary fish oil for lard on the physical and chemical properties of plasma low density lipoproteins (ldl), ten adult male cynomolgus monkeys were fed diets containing 11% (by weight) fish oil or lard in a crossover study consisting of two 15-week periods with a 6-week washout period in between. the atherogenic diets contained 40% of calories as fat with 0.26 mg cholesterol/kcal. periodic measurements of plasma lipids were made throughout the ... | 1991 | 2066665 |
| a simple technique for collecting blood of testicular origin: application to in vivo studies on testicular steroidogenesis in rats and macaca fascicularis. | a technique for rapidly collecting blood of testicular origin is described, one which can provide sufficient plasma amounts to investigate some steps of testicular steroid biogenesis in vivo in 2 species. in adult male rats, testosterone (t), androstenedione (4a) and 5-androstenediol (5ad) were determined in pampiniform plexus testicular venous blood (pptv) and peripheral (pv) blood samples before and 2 h after human chorionic gonadotropin (hcg). pptv concentration of 5ad was 0.83 +/- 0.1 ng/ml ... | 1991 | 2069857 |
| autogenous auricular cartilage graft for temporomandibular joint repair. a comparison of technique with and without temporary silastic implantation. | four macaca fascicularis monkeys underwent bilateral temporomandibular joint surgery including disc removal, condyle recontouring and disc replacement using autogenous auricular cartilage grafts. one side was treated with the cartilage graft alone while the other side was treated with a cartilage graft combined with a temporarily implanted 0.02 inch dacron-reinforced silastic sheet. the silastic sheeting was removed at twelve weeks after the initial surgery. the monkeys were sacrificed at fourte ... | 1991 | 2071692 |
| a collagen-based nerve guide conduit for peripheral nerve repair: an electrophysiological study of nerve regeneration in rodents and nonhuman primates. | when a peripheral nerve is severed and left untreated, the most likely result is the formation of an endbulb neuroma; this tangled mass of disorganized nerve fibers blocks functional recovery following nerve injury. although there are several different approaches for promoting nerve repair, which have been greatly refined over recent years, the clinical results of peripheral nerve repair remain very disappointing. in this paper we compare the results of a collagen nerve guide conduit to the more ... | 1991 | 2071700 |
| cationization of immunoglobulin g results in enhanced organ uptake of the protein after intravenous administration in rats and primate. | cationization of proteins in general enhances the cellular uptake of these macromolecules, and cationized antibodies are known to retain antigen binding properties. therefore, cationized antibodies may be therapeutic and allow for "intracellular immunization." the present studies test the hypothesis that the tissue uptake of cationized immunoglobulin g (igg) after intravenous administration may be greatly increased relative to the uptake of native proteins. the pharmacokinetics of cationized imm ... | 1991 | 2072295 |
| multiple alpha-globin genes in crab-eating macaques (macaca fascicularis). | alpha-globin genes in crab-eating macaques were found to be triplicated at high frequencies according to restriction-enzyme comparisons. the frequencies of triplicated alpha-globin genes in macaques originally from malaysia and indonesia were 0.432 and 0.275, respectively, while no triplication was found in individuals from either the philippines or northern and central thailand. quadruplicated alpha-globin genes were also observed, at frequencies of 0.045 (malaysia), 0.075 (indonesia), and 0.02 ... | 1991 | 2072861 |
| blood-ocular barrier permeability in experimental myopia. | vitreous fluorophotometry (vfp) was performed for myopic eyes induced by unilateral eyelid suturing of six young cynomolgus monkeys in order to study the permeability of the blood-ocular barrier. the eyelid fusion was temporarily cut and opened at about five-month intervals, and the dioptric power and axial length of test and control eyes were measured. vfp was carried out before and after intravenous injections of fluorescein-na. the inward permeability of the blood-retinal barrier (p(in)) was ... | 1990 | 2081837 |
| [electron microscopy and immunohistochemical studies of the intraocular pressure lowering effect of prostaglandin f2 alpha]. | topically applied prostaglandin f2 alpha (pgf2 alpha) has been shown to lower intraocular pressure in cynomolgus monkeys. in this study the morphological changes following topical treatment of seven cynomolgus monkeys with 4 micrograms pgf2 alpha isopropylester for 5-8 days were investigated and compared with the eyes of five normal animals. quantitative light microscopical, ultrastructural and immunhistochemical methods were used. no cellular signs of inflammation were seen in any of the eyes. ... | 1990 | 2086407 |
| fields of origin and pathways of the interhemispheric commissures in the temporal lobe of macaques. | the interhemispheric connections of the cortical areas of the temporal lobe and some neighboring regions were investigated in monkeys (macaca mulatta and macaca fascicularis) by anterograde autoradiographic tracing, following injection of radioactively labeled amino acids. the results revealed that the interhemispheric projections of the temporal lobe course through three interhemispheric commissures on their way to the opposite hemisphere. the anterior commissure receives fibers from virtually ... | 1990 | 2086614 |
| the site of reattachment of the extraocular muscle following hang-back recession. | the use of "hang-back" suspensions has been shown to be an effective means of weakening rectus muscles. the exact position where the muscle reattaches to the globe has, however, been questioned. we performed eight large hang-back recessions on the rectus muscles of cynomolgus monkeys. eight weeks postoperatively the attachment sites were determined by reexploration. six of the recessions were within 0.5 mm of the intended site. the muscles were found an average of 0.4 mm anterior to the intended ... | 1990 | 2086743 |
| localization and responses of neurones in the parieto-insular vestibular cortex of awake monkeys (macaca fascicularis). | 1. in four java monkeys (macaca fascicularis) 152 vestibular neurones were recorded in the parietal cortex located in the upper bank of the lateral sulcus near the posterior end of the insula. we called this region parieto-insular vestibular cortex (pivc). pivc extends about 6-8 mm in the anterior-posterior direction from the posterior part of the insula into the retroinsular region (stereotaxic co-ordinates: anterior 4-12 mm, lateral 16-19 mm and vertical 3-6 mm). 2. about two-thirds of the neu ... | 1990 | 2086773 |
| vestibular neurones in the parieto-insular cortex of monkeys (macaca fascicularis): visual and neck receptor responses. | 1. one hundred and fifty-two vestibularly activated neurones were recorded in the parieto-insular vestibular cortex (pivc) of four awake java monkeys (macaca fascicularis): sixty-two were tested systematically with visual stimulation and seventy-nine were tested with various somatosensory stimuli. with very few exceptions all vestibular neurones tested responded to visual and somatosensory stimulation, therefore being classified as polymodal vestibular units. 2. a most effective stimulus for all ... | 1990 | 2086774 |
| structure and function of the simian sinoatrial node (macaca fascicularis). | in isolated preparations of the simian (macaca fascicularis) heart, we studied the activation pattern within the sinoatrial node, using the conventional microelectrode technique. after electrophysiological experiments we subjected three preparations to a correlative light microscopical and two to an electron microscopical investigation. the sinoatrial node of the macaca fascicularis is characterized by unifocal impulse generation. the impulse is propagated preferentially in an oblique direction ... | 1990 | 2089159 |
| the cutaneous cervical plexus nerves of the crab-eating macaque (macaca fascicularis), eastern grey kangaroo (macropus giganteus), and koala (phascolarctos cinereus). | the origin, course and distribution of the cutaneous nerves of the cervical plexus were examined in the crab-eating macaque (4 body-halves), the grey kangaroo (5 body-halves) and koala (3 body-halves). the cutaneous nerves, n. auricularis magnus, nn. supraclaviculares, n. transversus colli, and n. transversus cervicis, were recognized. cranial and caudal branches were identified in the latter 2 nerves. some intermediate, relatively small branches were recognized between these main nerves. the n. ... | 1990 | 2093157 |
| effects of sensitization to dinitrochlorobenzene (dncb) on clinical pathology parameters and mitogen-mediated blastogenesis in cynomolgus monkeys (macaca fascicularis). | immunotoxicologic testing of drug candidates and environmental contaminants is of growing importance. cutaneous delayed type hypersensitivity (dth) is a convenient way of testing immune function in vivo. however, dth testing must not interfere with interpretation of other relevant parameters. we have evaluated the effects of sensitization and challenge with dinitrochlorobenzene (dncb) on clinical parameters routinely evaluated in toxicity testing and on lectin-mediated blastogenesis. female cyno ... | 1990 | 2093224 |
| parasympathetic denervation of the ciliary muscle following retinal photocoagulation. | cynomolgus monkeys underwent unilateral prp with xenon arc or argon or krypton laser light, employing burn intensity, size, spacing, and topography analogous to standard clinical (eg, diabetic retinopathy study) treatment. shortly thereafter, accommodative responsiveness to topical eserine and electrical stimulation of the ewn was diminished, accommodative responsiveness to systemic pilocarpine was enhanced, and the number of muscarinic receptors in the ciliary muscle was reduced in the prp-trea ... | 1990 | 2095033 |
| pneumotaxic mechanisms in the non-human primate: effect of the n-methyl-d-aspartate (nmda) antagonist ketamine. | we tested the possible involvement of n-methyl-d-aspartate (nmda) receptors in the central inspiratory-termination mechanism in non-human primates. inspiratory bursts were recorded from the phrenic nerve in macaca fascicularis monkeys paralyzed and ventilated by means of a servoventilator driven by the inspiratory discharge of the phrenic nerve. the central inspiratory termination mechanism was tested by withholding lung inflation. this transiently suppressed the vagal feedback from the lungs wh ... | 1990 | 2097589 |
| effect of thyroid hormone on epidermal growth factor-like immunoreactivity and growth velocity in cynomolgus monkeys. | to examine the potential role of epidermal growth factor (egf) in mediating the effects of thyroid hormone on linear growth, we measured serum egf levels by ria in cynomolgus monkeys before and during methimazole-induced hypothyroidism, and after 9 weeks of t4 replacement at different doses. ten castrated prepubertal monkeys were rendered hypothyroid by methimazole (0.0125% in drinking water for 12 weeks). methimazole was continued, and t4 was then administered for 9-week intervals. six weeks el ... | 1990 | 2100280 |
| visual transduction in cones of the monkey macaca fascicularis. | 1. visual transduction in macaque cones was studied by measuring the membrane current of single outer segments projecting from small pieces of retina. 2. the response to a brief flash of light was diphasic and resembled the output of a bandpass filter with a peak frequency near 5 hz. after the initial reduction in dark current there was a rebound increase which resulted from an increase in the number of open light-sensitive channels. the response to a step of light consisted of a prominent initi ... | 1990 | 2100987 |
| force-time breakage characteristics of food during simulated initial phase of mastication. | with the long range goal of gaining an insight into force control and muscle recruitment, it seems necessary to understand the task given to the masticatory apparatus. the purpose of this study was to characterize food breakage properties, and to study the influence of different compression speeds and occlusal morphologies on the categorized food properties. experiments were carried out by means of a standard instron instrument, modified with a switching relay. a stylus with 45 degree angulation ... | 1990 | 2101450 |
| detection of the ovulatory-luteinizing hormone surge with an enzyme-linked immunospecific human urinary luteinizing hormone assay: applicability to nonhuman primates. | heterologous antibodies have frequently been used to develop assays in other species. human urinary lh kits, widely available for predicting the lh surge, offer a unique opportunity to determine the timing of ovulation and mating in nonhuman primates. we tested three commercially available ovulation predictor kits for utility in two macaque species. midfollicular, midcycle, and castrate urines and their corresponding serum samples were assessed for lh activity using established rias as well as u ... | 1990 | 2105250 |
| long-term parenteral nutrition in unrestrained nonhuman primates: an experimental model. | a freely mobile jacket and tether system was developed for the investigation of total parenteral nutrition (tpn)-induced metabolic bone disease and complications of prolonged tpn in 12 macaca fascicularis nonhuman primates. the animals received tpn for 49 +/- 7 d (means +/- sem), providing 82 +/- 2 kcal.kg-1.d-1. serum glucose increased from 3.6 +/- 0.2 mmol/l at baseline to 8.3 +/- 1.9 mmol/l (p less than 0.01) during tpn, and serum albumin decreased from 38 +/- 1 g/l at baseline to 29 +/- 1 g/ ... | 1990 | 2106776 |
| apo a-i metabolism in cynomolgus monkeys: male-female differences. | female cynomolgus monkeys have significantly higher plasma apo a-i concentrations than males (p = 0.04) and are able to maintain higher levels than the males even after consuming a high-cholesterol diet that severely depresses the apo a-i concentration in primates (p less than 0.05). the mechanism responsible for this difference was investigated by comparing apo a-i turnover (synthesis and catabolism) in males and females consuming monkey chow and in a separate group of males and females that ha ... | 1990 | 2106919 |
| isolation of a cdna from the virus responsible for enterically transmitted non-a, non-b hepatitis. | major epidemic outbreaks of viral hepatitis in underdeveloped countries result from a type of non-a, non-b hepatitis distinct from the parenterally transmitted form. the viral agent responsible for this form of epidemic, or enterically transmitted non-a, non-b hepatitis (et-nanbh), has been serially transmitted in cynomolgus macaques (cynos) and has resulted in typical elevation in liver enzymes and the detection of characteristic virus-like particles (vlps) in both feces and bile. infectious bi ... | 1990 | 2107574 |
| the metabolism of nafimidone hydrochloride in the dog, primates and man. | 1. the biotransformation of nafimidone, an imidazole-substituted anticonvulsant, has been studied by characterization of urinary metabolites in dogs, cynomolgus monkeys, baboons and man. 2. the biotransformation of nafimidone in these laboratory animals and man is initially very similar, in each case proceeding by reduction to the aliphatic alcohol metabolite, nafimidone alcohol or 1-[2-hydroxy-2-(2-naphthyl)ethyl]imidazole. 3. further transformation of this metabolite involves oxidation in the ... | 1990 | 2109431 |
| l-662,583 is a topically effective ocular hypotensive carbonic anhydrase inhibitor in experimental animals. | 1. l-662,583 was a potent inhibitor in vitro of purified, human erythrocyte carbonic anhydrase ii, possessing an ic50 of 0.7 nm. the ic50 values for mk-927, acetazolamide and methazolamide were 13.0 nm, 10.8 nm and 21.2 nm, respectively. 2. a 1 h pretreatment with one 50 microliters drop of a 0.1% solution of l-662,583 blocked carbonic anhydrase activity in a homogenate of the iris + ciliary body of albino rabbits by 63%. similar treatment with 0.1% suspensions of acetazolamide and methazolamide ... | 1990 | 2110013 |
| endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates. | atherosclerosis impairs endothelium-dependent relaxation of large conduit arteries. because coronary resistance vessels are spared from the development of overt atherosclerosis, endothelium-dependent responses were examined in these vascular segments. malaysian cynomolgus monkeys (n = 6) were made atherosclerotic by being fed a 0.7% cholesterol diet for 18 months. control monkeys (n = 6) were fed a standard diet. coronary microvessels (122-220 microns) were studied in a pressurized (20 mm hg), n ... | 1990 | 2110036 |
| [primates in the study of oocyte maturation]. | in the mammalian oocyte, meiosis is initiated during fetal life. meiosis proceeds up to the diplotene stage of the first prophase and is arrested at birth and the oocyte presents a nuclear structure known as germinal vesicle (gv). meiotic arrest persists until sexual maturity, when one or more oocytes, the number dependent on the species, reinitiate their reduction division at each cycle. the series of event, initiated by the breakdown of the germinal vesicle (gvbd) and completed with formation ... | 1990 | 2110645 |
| serial transmission of a putative causative virus of enterically transmitted non-a, non-b hepatitis to macaca fascicularis and macaca mulatta. | in order to establish an animal model and to identify a causative virus of enterically transmitted non-a, non-b hepatitis, macaca fascicularis was inoculated with a fecal extract obtained from myanmar patients with acute sporadic non-a, non-b hepatitis. the primates developed acute hepatitis exhibited by a transient elevation of aminotransferases in the sera and occurrence of hepatic necroinflammation between 2 and 4 weeks postinoculation. subsequent second passage of the fecal extract made from ... | 1990 | 2112652 |
| occurrence and character of a putative causative virus of enterically-transmitted non-a, non-b hepatitis in bile. | the present investigation confirms the possibility that the etiological agent of enterically-transmitted non-a, non-b (et-nanb) hepatitis (type e hepatitis), multiplied in hepatocytes, is excreted into the feces via bile. the fecal extract was inoculated into 7 cynomolgus monkeys. bile juice was collected directly from the gallbladder by needle puncture after abdominal operation 3 to 6 times during the experimental course. all 7 monkeys developed elevated serum aminotransferases, which began gra ... | 1990 | 2112653 |
| distribution of angiotensin ii receptors in the brain of nonhuman primates. | angiotensin ii binding sites were demonstrated at discrete nuclei in the brain of three nonhuman primate species by autoradiography, using the agonist ligand, [sar1]aii. although there were some differences in location of the binding sites, all three species exhibited a characteristic pattern of distribution in areas related to water intake, vasopressin secretion, and blood pressure regulation through modulation of sympathetic activity. studies in the cynomolgus monkey with the antagonist ligand ... | 1990 | 2113279 |
| premature luteinizing hormone surges in menopausal gonadotropin-stimulated cycles in monkeys: lack of initiation by progesterone. | the occurrence of spontaneous luteinizing hormone (lh) surges in women receiving human menopausal gonadotropins (hmg) for in vitro fertilization-embryo transfer is a significant clinical problem. one hypothetical mechanism is that premature progesterone (p) secretion occurring in the high estradiol (e2) milieu produced by hmg triggers the spontaneous lh surge. to investigate this possibility, 11 rhesus and cynomolgus monkeys were stimulated with hmg. at maximal ovarian stimulation, monkeys were ... | 1990 | 2113486 |
| enterically-transmitted non-a, non-b hepatitis. | more than 50% of acute viral hepatitis occurring in some developing countries appears to be unrelated to infection by hav or hbv and accumulating evidence suggests that a high proportion of this non-a, non-b hepatitis (nanb) is enterically transmitted. epidemics or outbreaks of enterically-transmitted nanb (et-nanb) have been documented in the soviet union, nepal, burma, pakistan, india, borneo, somalia, sudan, ivory coast, algeria, and mexico. these outbreaks primarily affect young to middle-ag ... | 1990 | 2116213 |
| characterization of lymphocyte subpopulations in the blood of the cynomolgus monkey using flow cytometry. | this study was performed to assess the usefulness of flow cytometry in comparison with acid alpha-naphthyl acetate esterase (anae) staining for the enumeration of lymphocyte subpopulations in cynomolgus monkeys. for flow cytometry, use was made of mouse antihuman leukocyte monoclonal antibody (t11), recognized to undergo cross-reaction with monkey t lymphocytes or antimonkey igg serum labelled with fluoroscein isothiocyanate. the percentages of lymphocyte subpopulations in mononuclear cells of t ... | 1990 | 2116470 |
| role of lipoprotein lipase in the regulation of high density lipoprotein apolipoprotein metabolism. studies in normal and lipoprotein lipase-inhibited monkeys. | mechanisms that might be responsible for the low levels of high density lipoprotein (hdl) associated with hypertriglyceridemia were studied in an animal model. specific monoclonal antibodies were infused into female cynomolgus monkeys to inhibit lipoprotein lipase (lpl), the rate-limiting enzyme for triglyceride catabolism. lpl inhibition produced marked and sustained hypertriglyceridemia, with plasma triglyceride levels of 633-1240 mg/dl. hdl protein and cholesterol and plasma apolipoprotein (a ... | 1990 | 2117022 |
| a comparison of l-671,152 and mk-927, two topically effective ocular hypotensive carbonic anhydrase inhibitors, in experimental animals. | l-671,152 is a water-soluble, carbonic anhydrase inhibitor structurally similar to mk-927, a carbonic anhydrase inhibitor that, on topical administration, lowers the intraocular pressure (iop) of experimental animals and humans. l-671,152 was more potent than mk-927 at inhibiting purified, human erythrocyte carbonic anhydrase ii in vitro, as reflected in their respective ic50 values of 0.16 nm and 1.19 nm. both compounds were compared for topical, ocular hypotensive activity in pigmented rabbits ... | 1990 | 2117519 |
| production of immunoglobulin a protease by streptococcus pneumoniae from animals. | human isolates of streptococcus pneumoniae tested by traditional immunochemical methods produce a protease that cleaves human immunoglobulin a1 (iga1) into fab and fc fragments. the protease may be an important virulence factor, but studies of its pathogenetic significance have been hampered by lack of a suitable animal model. since s. pneumoniae is a respiratory pathogen for several species of animals, we sought to determine whether isolates of this organism from animals with pneumococcal infec ... | 1990 | 2117567 |
| characterization of lysosomal enzymes from cultured cynomolgus monkey trabecular meshwork cells. | the current study characterizes selected properties of lysosomal enzymes associated with cynomolgus monkey trabecular meshwork (mtm) cells. these proteins may participate in the turnover of macromolecules involved in regulating the aqueous outflow. intracellular levels of lysosomal enzymes in mtm cells were similar to those found in cultured human fibroblasts. the presence of ammonium chloride increased the secretion rate of certain lysosomal enzymes from 47 to 122% of normal. column chromatogra ... | 1990 | 2117598 |
| oral activity of the growth hormone releasing peptide his-d-trp-ala-trp-d-phe-lys-nh2 in rats, dogs and monkeys. | the purpose of this study was to evaluate the growth hormone (gh) releasing activity of orally administered his-d-trp-ala-trp-d-phe-lys-nh2 (ghrp-6, sk&f 110679) in rats, dogs and monkeys. rats were administered ghrp-6 orally by gavage or parenterally through femoral artery catheters. blood was collected before and after ghrp-6 administration for estimation of plasma gh and comparison of gh changes resulting from enteral and parenteral administration of the peptide. ghrp-6 was administered to do ... | 1990 | 2117689 |
| highly vectorial secretion of inhibin by primate sertoli cells in vitro. | having recently demonstrated highly vectorial and fsh-stimulated inhibin secretion by immature rat sertoli cells in vitro, we wished to determine if vectorial secretion of inhibin was also characteristic of primate sertoli cells. by adapting techniques for isolation of sertoli cells from testes of the immature rat and cynomolgus monkey. sertoli cells were isolated from immature baboon testes. sertoli cells were then plated onto matrix-impregnated porous filters and cultured in twin chamber assem ... | 1990 | 2121770 |
| biosynthesis of 20-hydroxyeicosatetraenoic acid (20-hete) and 12 (s)-hete by renal cortical microsomes of the cynomolgus monkey. | renal cortical microsomes of the cynomolgus monkey, macaca fascicularis, were incubated with [14c] arachidonic acid in the presence of nadph. the two main metabolites were identified as 20-hydroxyeicosatetraenoic acid (20-hete) and 12(s)-hydroxyeicosatetraenoic acid (12(s)-hete) by capillary gc-ms and by chiral phase hplc. 12(s)-hete was formed in highly variable amounts by the very same preparation of microsomes on different occasions. the microsomal biosynthesis of 12(s)-hete was increased sev ... | 1990 | 2122910 |
| group a rotavirus infection in animals from an animal house and in wild-caught monkeys. | randomly selected samples from different animal colonies from two laboratory animal houses and from the wild-caught monkeys were tested for the presence of anti-rotavirus antibodies to estimate the rates of infection with group a rotavirus. antibodies to the common group a rotaviral antigen were detected by a competitive enzyme-linked immunosorbent assay (elisa) using reagents of who elisa rotavirus detection kit. the results of the study showed that white mice, albino rats, and guinea pigs from ... | 1990 | 2122998 |
| changes in plasma factor viii complex and serum lipid profile during atherogenesis in cynomolgus monkeys. | if endothelial injury plays a prominent role in early atherogenesis, the plasma levels of von willebrand factor (vwf), which is made within and normally released from endothelial cells, might be expected to rise as a marker of the cellular damage. to evaluate this hypothesis, we measured plasma vwf (as viiir:ag), factor viii:c, and serum lipids serially up to 37 weeks in 29 adult male cynomolgus monkeys on an atherogenic diet. factor viii:c peaked at 113% above baseline by week 10 (p less than 0 ... | 1990 | 2123089 |