Publications

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chlorpromazine in prophylaxis of myocardial infarction. 200187881
hazards of the appetite suppressant phenylpropanolamine. 200187921
sex ratio in glomerulonephritis. 200187939
george armitage. 200187943
dissolution of biliary duct stones with mono-octanoin. 200187955
measurement of tissue ph in skin by glass microelectrodes.alterations in metabolic activity may be used as an indicator of tissue perfusion and haemodynamic status in peripheral ischaemia. a new type of microelectrode was used to measure ph in the skin of patients with vascular disease, and a decrease in ph was demonstrated along the leg, commensurate with the severity of the disease. measurement of skin ph by this technique is easy and may be useful for assessing tissue perfusion or skin viability in other conditions.200187967
minaxolone: a new water-soluble steroid anaesthetic.the induction characteristics of minaxolone, a water-soluble steroid anaesthetic, were studied in fit patients undergoing minor urological or gynaecological operations. minaxolone acted as rapidly as thiopentone. a dose of 0.25 mg kg-1 did not always produce anaesthesia in patients who had not received premedication but 0.5 mg kg-1 was an adequate dose. excitatory effects were less common with the higher doses of anaesthetic. these effects were usually slight and rarely interfered with the cours ...200187969
psychiatrists with blinkers. 200187973
major malformations in infants born of women who worked in laboratories while pregnant. 200187979
septo-optic dysplasia and maternal age. 200187980
[diagnostic value of laboratory and scintigraphic investigations in young infants with cholestatic jaundice (author's transl)].the diagnostic value of laboratory and scintigraphic examination techniques in young infants with cholestatic jaundice will be discussed. the correct diagnosis of neonatal hepatitis or extrahepatic biliary atresia cannot be derived from such investigations as determination of bilirubin, enzyme activities, immunologic or serologic parameters or scintigraphy of the liver. only quantitative changes of serum lp-x before and after administration of cholestyramin and the modified rose-bengal test may ...200187997
inhibition of reverse transcriptase activity by benzophenanthridine alkaloids.benzophenanthridine alkaloids, fagaronine 4, o-methylfagaronine 5,nitidine 1, allonitidine 3 and methoxydihydronitidine 2 have been shown to possess inhibitory activity against reverse transcriptase of rna tumor viruses. the enzyme inhibition (50%) by these alkaloids was found in the range of 6-60 microgram per milliliter of the reaction mixture when polynucleotide-oligodeoxynucleotide complexes were used as template primers. the results suggested that the benzophenanthridine alkaloids interacte ...197988001
effect of double infection of cowpox virus-infected cells with paramyxovirus (sendai virus) on formation of cowpox virus-specific cell surface antigen.the formation of cowpox virus-specific cell surface antigen (cpv s-ag) was significantly enhanced by double infection with hvj (sendai virus). simultaneous double infection, superinfection with hvj and superinfection with cpv of cells persistently infected with hvj similarly enhanced the formation of cpv s-ag, while pre-infection with hvj was ineffective. to be effective, cells must be infected at a m.o.i. of greater than or equal to 1.0 and hvj gene functions had to be expressed. the hvj-infect ...197888002
[behavior of alpha 2-macroglobulin and alpha 1-antitrypsin in mature diabetics]. 200188025
the validity of parental reporting of infant development.a developmental questionnaire, encompassing the ages from 4 weeks to 36 months, has been devised that, when completed by parents, can be used to screen children as being developmentally normal, questionable, or abnormal. a total of 526 infants were screened by this questionnaire at 28 weeks of age and then examined at 40 weeks of age by a full gesell developmental and neurologic examination. underscreening of those with major abnormalities was 2.6%, and of those with minor abnormalities, 10%. ov ...200188036
nursing care study: a patient with benign prostatic hyperplasia. 200188044
donor selection in platelet transfusion therapy of alloimmunized thrombocytopenic patients. 200188057
a simple approach to improved visualization and identification of the vessels of the lower part of the leg. 200188076
germ-cell tumors of the testis: improved results in a prospective study using combined modality therapy and biochemical tumor markers. 200188077
[the inoperable carcinoma of the esophagus: results from radiation therapy and conclusions for irradiation planning (author's transl)].conclusions are drawn for irradiation planning from treatment results of 161 patients with inoperable esophageal carcinomas, comparable with reference to the technique applied using moving-field irradiation and delivering a total focal dose of 6000 rd. the palliative effect of radiation therapy is obtained by measurable dilatation of the stenosis in more than 90% of the patients. 5-year survival, however, was found only in cases of an average target volume comprising 500 cm3 within the 80% isodo ...200188087
individual mice recognize the complex nature of h-2 antigens; unexpected reactions (anti-kk) in anti-balb/c-h-2d sera produced in the balb/c-h-2db mutant. 200188092
h-2l locus: alleles, products, and specificities. 200188093
mlc and cmc reactivity and specificity of idiotype-specific lymphoid cells enriched for histocompatibility (h-2) antigens. 200188095
a new strategy to improve kidney graft survival: the induction of cml nonresponsiveness. 200188102
opsonization of alloreactive ly-1+ t cells by antigen-antibody complexes containing free i-a determinants. 200188104
[peridural anesthesia in transurethral operations]. 200188111
[problems in the therapy of vasomotor rhinitis]. 200188118
[mineral oil emulsion of the gamma isomer of hcch in sheep psoroptic mange]. 197988121
inhibition of sv40 replication by 5-azacytidine: effect on dna synthesis and conformation. 200188126
characterization of an amphotropic murine c-type virus that is nb-tropic. 197988128
[attempt at determination of specific granulocytic antigens using granuloagglutination sera. i. diversity of antigens demonstrated using granulocytotoxins and granuloa-glutinins]. 200188129
[effect of antiglial and antineuronal immunoglobulins on the processes of retention and reproduction of a reinforced habit]. 197988137
free flap in an experiment - a histological view. 197888142
orthochromatic leukodystrophy with pigmented glial cells. an adult case with clinical-anatomical study.the case history is reported of a woman who died at the age of 36, at the conclusion of 11 years progressive neurological and psychiatric symptomatology. the anatomical and histological examination demonstrated an orthochromatic leukodystrophy with pigmented glial cells. attention is drawn to the difficulty of finding these cells, which serve to differentiate between the unusual and the "simple" form of the disease. in the reported patient the pigmented cells were found around the vessels and on ...200188156
human corneal endothelium in organ culture. the influence of temperature and medium of incubation.forty-four human corneas from patients between 21 and 86 years were incubated in eagle's minimum essential medium with earle's salts 10--46 h post mortem. the influence of incubation temperature and composition of the medium on endothelial survival was evaluated. whole corneas were stained by alizarine red. recent cell loss was indicated by morphological alterations in the endothelial pattern. after 20--28 h of incubation minimum cell loss was found at 31 degrees c when 8% dextrane-250 and 20% s ...197988158
anaphylatoxin-induced shock and two patterns of anaphylactic shock: hemodynamics and mediators.in the dog, different cardiorespiratory reactions were identified in two types of anaphylactic shock and in c5a-at (anaphylatoxin)-induced shock. all three types had in common a portal blood pooling with consequent decrease in the venous return, cardiac output, and arterial pressure. in anaphylaxis (a) of the first type, at a low titer of hemagglutinating antibodies, the latent period was 68 s and heart and lung function was unchanged. in the second type, at high titer, the latency was 19 s and ...197988165
[transposition of the colon in esophageal tumors]. 200188167
research needs in low vision.research needs are presented for several areas of low vision: (1) reading and learning, (2) new low-vision aids, (3) modifying the environment, (4) utilization of disciplines, (5) new technologies, and (6) integrating low-vision services.200188182
binding of antigen to surface ig during in vitro hyposensitization of isolated rat mast cells.the mechanism of in vitro hyposensitization was examined in isolated rat mast cells. surface distribution of immunoglobulin was examined by immunofluorescence technique. hyposensitization could be ascribed neither to changes in the distribution of surface immunoglobulins nor to capping or shedding phenomena. the distribution of cell-bound antigen and the number of antigen-positive cells (patch-bearing cells) was not changed by hyposensitization. the binding of antigen to surface ig was quantitat ...197988188
audiotape slide teaching: use with automated and simple apparatus.using a cross-over design trial and a series of 20 audiotape slide programmes on clinical physics and measurement, no difference in teaching effectiveness was found between their use with synchronised automated apparatus and simple manual equipment. in both cases 91% of the main lecture points were immediately recalled and there was a significant gain in knowledge from an average pre-test mcq score of 43%--76% post-test score. the advantages and disadvantages of automated and simple equipment we ...200188189
tannic acid staining and extraction of enzymes in polyacrylamide gel electrophoresis. 200188190
denaturization of allergen p: effect on allergenicity, antigenicity and immunogenicity.when allergen p was denatured by 8m urea, the modified molecule still reacted with ige specific for the native allergen but not with hemagglutinating antibodies. heating at 100 degrees c abolished the reaction in both cases. the results suggested differences between allergenic and antigenic capacities which may be based on structural differences of the antigenic determinants.197988195
immunologic diagnosis of cancer.immunologic tests for the specific detection of tumor specific antigens would provide a method for the early detection of malignancy. using immunodiffusion and immunofluorescent techniques it is possible to measure antigenic markers. carcinoembryonic antigen and alpha1 fetoprotein are helpful in following treatment and prognosis of a patient. skin tests and tests for cellular immunity help to measure the immune competence of the cancer patient.200188196
effects of passively and actively acquired antibody on bovine campylobacteriosis (vibriosis). 197988198
types of striatonigral neurons labeled by retrograde transport of horseradish peroxidase. 197988205
a comparative study of o'nyong nyong virus with chikungunya virus and plaque variants.two plaque variants of chikungunya (chik) virus were serologically compared with o'nyong nyong (onn) virus in order to elucidate the reported one way antigenic relationships between the two viruses. three different hypotheses are examined and evidence is shown to support one of them. comparison of some biological properties of the viruses showed onn to be distinct in some respects. all viruses and variants were found to replicate in anopheles gambiae cells.197988212
gomori's trichrome stain. 200188216
reverse transcriptase in a patient with scleroderma. 200188220
folate uptake in l1210 cells: mediation by an adenine transport system. 200188221
induction of alkaline phosphatase activity in hela cells. inhibition by xanthine derivatives and thermostability studies. 200188228
[simple method of detection of fc receptor sites on cells].a bacterial adhesion technique for identification of fc-receptor bearing cells is based on the ability of staphylococcus aureus, cowan 1 strain, to form rosettes with cells previously treated with immune complexes or heat aggregated ig g. the new technique is distinguished from other fc-receptor detection methods by its simplicity and ease of detection of both immune complexes and aggregated igg-binding cells.197988236
[the antibacterial action on dental plaque of antibiotics used in dentistry. 2. in vitro experiments on streptococcus mutans, staphylococcus aureus and fusobacterium nucleatum (author's transl)]. 197788239
carcinoma of the esophagus: pretreatment assessment, correlation of radiation treatment parameters with survival, and identification and management of radiation treatment failure.between january 1969 and february 1975, 344 patients with carcinoma of the esophagus were managed primarily at the princess margaret hospital, toronto. one hundred sixty-eight (168) of the patients were treated palliatively and 176 of the patients were treated by radical doses of radiation, surgical resection or both. survival of the radical treatment group was biphasic, the steeper component being identical to the survival of the palliative treatment group, thereby representing a group of patie ...200188252
expression of endodermally derived and neural crest-derived differentiation antigens by human lung and colon tumors. 197988254
the effect of combination chemotherapy on neutrophil function in cancer patients.the effect of adjuvant and palliative combination chemotherapy (vincristine, meccnu, 5-fluorouracil) on neutrophil function was studied in 18 patients prior to and during the anticancer treatment. neutrophil responsiveness was assessed by leukocyte chemotaxis and chemiluminescence. no impairment could be observed in the circulating phagocyte function in either of the 2 groups before or in connection with short or long-term treatment.200188258
surface antigens of human glioma cells shared with normal adult and fetal brain. 197988260
properties of a basement membrane-related glycoprotein synthesized in culture by a mouse embryonal carcinoma-derived cell line.two glycoproteins, gp-1 and gp-2, have been isolated from an extracellular membrane synthesized in cell culture by an embryonal carcinoma-derived cell line. the amino acid and carbohydrate compositions have been determined. both proteins are rich in half-cystine residues and contain approximately 12-15% carbohydrate. antibodies have been obtained against one of the glycoproteins, gp-2, in rabbits. the antibody reacts with basement membranes from adult mouse and human kidney glomeruli and tubules ...197988263
immune responses to weakly immunogenic virally induced tumors. v. short in vitro cultivation of yac changes its antigenic properties. 197988269
hepatic function assessed (in rats) during chemotherapy with some anti-cancer drugs.using rats, we studied how best to assess hepatic damage after administering therapeutic doses of each of five anti-cancer drugs or of the hepatotoxin, carbon tetrachloride. as indexes, we compared measurement of the concentration of administered antipyrine in plasma with measurement in serum of alpha-fetoprotein or of the activities of five enzymes that reportedly best reflect hepatic damage. the biological half-life of antipyrine in the plasma was increased more than threefold on pretreating t ...197988282
4th international workshop on human gene mapping. report of the committee on the genetic constitution of the x and y chromosomes. 197888299
the h-y antigen:production of antibodies, detection, and cross-reaction between mouse, rat, and human. 197888303
t antigen banding on chromosomes of simian virus 40 infected muntjac cells.chromosomes were prepared from mitotic munjac cells 48 to 72 h after infection with sv40 virus. when stained for sv40 t antigen by indirect immunofluorescence, all chromosomes within an infected cell were fluorescent, indicating the presence of t antigen. furthermore, the chromosomes were not uniformly stained but appeared to have regions of high and low fluorescence intensity. a variety of controls showed that the banding patterns are specific and highly reproducible and may indeed reflect the ...197988306
palliation of massive hemoptysis from unresectable carcinoma of the lung.unresectable carcinoma of the lung has traditionally been recognized as a contraindication to surgery in massive hemoptysis. a 60-year-old man had massive hemoptysis. at surgery an unresectable neoplastic mass invading the mediastinum and great vessels was encountered. subtotal resection was accomplished using a stapler (autostapler). the margins of the bronchial and vascular staples were of necessity placed directly through the tumor. the patient had an uneventful recovery and has survived six ...197988310
histopathologic study of esophageal squamous cell carcinoma treated preoperatively with pingyangmycin. 200188311
rod-shaped organism in the liver of a patient with whipple's disease.histological review of a liver biopsy from a patient with known whipple's disease revealed a prominence of kupffer cells containing pas-positive granules. electron microscopy revealed rod-shaped organisms in the kupffer cells but the presence of these structures were not associated with overt liver injury. this is thought to be the first reported demonstration of these bacillary bodies in this location.200188317
changes in seizure susceptibility, sleep time and sleep spindles following thalamic and cerebellar lesions.the present experiment attempted to clarify conflicting evidence on the relationship of sleep spindles to seizure activation. seizure thresholds were calculated in minutes post-injection following ip administration of the convulsant drug monomethylhydrazine (mmh) to cats with lesions intended to alter the occurrence of spontaneous 12-15 c/sec sleep spindles recorded from sensorimotor cortex. twelve cats with bilateral cortical and subcortical recording electrodes were divided into 3 groups recei ...197988323
analogue analyser for on-line eye movement detection.a system of single movement detection is obtained by discriminating the velocities and orientations of eye ball displacements. the orthogonal components of eye velocity (vx and vy) are generated from the horizontal (x) and the vertical (y) components of the movements by means of two derivative circuits and the velocity modulus (v) is generated through a vector operator from vx and vy. the onset and end of individual movements are detected on the basis of a preselected v, vx or vy threshold and, ...200188325
nocturnal and diurnal sleep in macaca sylvana.in macaca sylvana restrained in chairs, continuous 24 h recordings were obtained of scalp eeg, neck emg, bilateral eog, motility of the head and lever manipulation. a total of 32 days were studied in 8 monkeys. recordings were divided into epochs of 30 sec and analyzed in a pdp-12 computer. four stages of sleep and 5 stages of wakefulness were identified by combination of the above data. results were as follows: (1) during the night, there was 21% wakefulness and during the day 20% sleep, includ ...197988327
spinal evoked potential in man: a maturational study.summated evoked potentials to peroneal nerve stimulation which arise in the cauda equina and spinal cord afferent pathways were recorded from surface electrodes placed over the spine of 95 infants, children and adults. the conduction velocity of these potentials from lumbar to cervical recording sites was calculated. additionally, segmental conduction velocities over peroneal nerve, caudal and rostral spinal cord were determined. in all age groups the speed of conduction up the spine was non-lin ...197988331
event-related potential changes in healthy aged females.neurophysiological changes in the central nervous system were demonstrated with eeg even-related potentials in healthy, aged women. compared to young women, the aged women showed decreased amplitude of the late sustained potential (sp), increased p2 latency, disruption of the normal stimulus intensity-response amplitude function of p2 and increased amplitude of the p1 component. these age-related changes are interpreted as neurophysiological reflections of cns deterioration found in non-senile e ...200188334
automatic recognition of inter-ictal epileptic activity in prolonged eeg recordings.a method of automatic recognition and quantification of inter-ictal epileptic activity in the human eeg had previously been developed and tested using short recordings from awake subjects. this paper describes the adaptation of the method for use during overnight recordings in free-moving unattended patients, in combination with the already existing seizure monitoring system. eeg s were recorded from scalp and sphenoidal electrodes, using cable telemetry and a pdp-12 computer. the spike and shar ...197988339
vestibulo-ocular responses during the states of sleep in the cat.the vestibulo-ocular response (vor) was recorded during natural sleep in cats with chronically implanted electrodes. by using a small amplitude sinusoidal head rotation (11 degrees) peak-to-peak at 0.4 hz) which elicited only slow compensatory eye movements, the vor amplitude was found to decrease steeply (down to 40% or less) during slow-wave sleep. the phase of the vor with respect to head position remained approximately constant. with a larger amplitude of sinusoidal rotation (320 degrees pea ...197988340
interference suppression for eeg recording during open heart surgery.a device for recording the eeg during open heart surgery is described. it differs from most standard equipment in two ways. first, the input circuit is completely floating from earth and will withstand 500 v dc. second, radiofrequency (rf) shielding and filtering permits continuous recording of the eeg during electro-surgery in the operating room. the almost undisturbed recording permits on-line continuous eeg monitoring by means of quantitative signal analysis methods.200188350
differential arousal response to gustatory stimuli in the awake rabbit.ecog arousal response as elicited by deionized water and by several concentrations of sweet, salty, sour and bitter tasting substances, all applied intraorally, were studied in the awake restrained rabbit. the study was carried out on 17 chronic preparations of adult male animals (2.6 kg average body weight). water as a stimulant was presented in 60 trials and tastants across qualities and concentrations in 245 trials. arousal was quantitatively characterized by its duration, frequency increment ...197988352
system for studying the delta rhythm during sleep and its topographical amplitude distribution.an analogue system of processing all-night sleep eeg records which leads to the representation of sleep cycles by the continuous variation of the amplitude parameter in a given frequency band is described. the curves obtained are analogous to those resulting from more sophisticated computerized analyses. the cycles which they outline are in good concordance with those of the classic hypnogram. moreover, the simplicity and the rapidity of the processing easily allow its application to multiple ee ...200188356
amplitude of evoked potentials and degree of event-related desynchronization (erd) during photic stimulation.the variations in amplitude of visual evoked potentials (veps) and parallel changes in amount of event-related desynchronization (erd) of the rhythmic activity within the alpha band were studied in central derivations of scalp eeg, in 10 normal subjects. two methods were used to estimate the amplitude of veps in small groups of 10 responses: (1) inverse and matched filtering techniques; (2) two-way rank analysis of variance by the friedman test. the two methods gave similar results and two group ...200188358
individual differences in the human electroencephalogram during quiet wakefulness. 197988364
kinetic complexity of nuclear poly(a)-containing rna in normal and regenerating rat liver.poly(a)-containing rna isolated from liver nuclei of untreated rats and 3 h or 12 h after partial hepatectomy or sham operation was hybridized to the complementary dnas (cdnas). in the homologous reactions two major components could be seen. when compared to normal liver, the complexity of the least abundant class was lower in nuclei from livers 3 h after partial hepatectomy and was higher in those isolated 12 h after operation. the heterologous reactions revealed an increase of some abundant p ...197988367
relative effectiveness of spinal cord and purified myelin basic protein in producing resistance to experimental allergic encephalomyelitis.isolated myelin basic protein (mbp) was less effective than an equivalent amount of spinal cord in inducing protection against experimental allergic encephalomyelitis produced by a challenge of either cord, purified myelin or mbp. complete protection was only obtained when an mbp challenge was preceded by spinal cord treatment. there was a 100% incidence of disease in the guinea pigs pretreated with mbp before challenge with spinal cord or myelin, but the onset was delayed by 3--4 weeks and the ...197988369
leishmania mexicana and leishmania tropica: cross immunity in c57bl/6 mice. 197988370
isolation of antibodies specific for the carbohydrate binding site of concanavalin a. 200188373
proton relaxation enhancement to probe the effects of antigen binding on pig antibody structure. 197988375
temperature-induced incorporation of gramicidin a into lysolecithin micelles demonstrated by 13c nmr. 200188376
renal cortex sialyltransferase activity upon tamm-horsfall glycoprotein, fetuin and rat glomerular basement membrane. 197988378
[spontaneous rosette forming, fc and complement receptor bearing lymphocytes in pediatric diseases].investigations with lymphocyte subpopulations were made in 51 children aged from 1-14 years with infections of the upper airways, with acute leukaemias, and other malignant diseases. t-lymphocytes were registered by means of the spontaneous rosette test. the attempt of proving b-lymphocytes was made by means of an eac test with human erythrocytes, anti-d-immunoglobulins and human complement. the results were compared with those obtained by an eac test with sheep erythrocytes, sheep haemolysin an ...197988386
electroimmunoassay of factor ix in patients with liver damage and vitamin k unresponsive coagulation disorder.factor ix antigen and activity were assayed in a group of patients with liver disease and in a group of patients in coumarin therapy. in patients with liver disease there was a similar decrease in activity and antigen. on the other hand factor ix activity is decreased in coumarin treatment with factor ix antigen remaining normal. factor ix electrophoretic mobility in liver disease is normal.200188391
[activation by means of various adsorbents. (contribution to the mechanism of contact activation of the blood coagulation process)].20 different adsorbing substances were examined for the purpose of determining physico-chemical parameters influencing the contact activation in the partial thromboplastin time (ptt). in the course of these examinations the prerequisites for the process under way were found to exist in a low adsorbing activity of the substance used as a surface and in the reversibility of adsorption. the effect activating the contact will depend on surface conditions and to a lesser degree on its size. an even c ...200188393
[diagnosis and therapy of hypotensive circulatory disorders in general practice. experiences with gutron using the thulesius-diagram for diagnosis and supervision of therapy].the alpha-adrenergic stimulating agent gutron, given orally for 10 days, induced a subjective and objective improvement of orthostatic disorders in a total of 114 hypotensive patients in 7 general practices. the use of the thulesius diagram in diagnosing orthostatic disorders further improved the rate of success and diminished the frequency of side effects distinctly. gutron is indicated in all patients with a systolic blood pressure fall of at least 10 mmhg and a concomitant rise in heart rate ...200188400
[the problem of hepatic dysfunction of the diagnosis of hypernephroid kidney carcinomas (stauffer syndrome)].in 43 patients with histologically proved hypernephroid kidney cancer evaluation of the electrophoretic results, serum alkaline phosphatase, thromboplastin time (quick's time) and bromthalein retention (n = 10) was carried out. as a control group the serum values of 10 patients with clinical tentative diagnosis of hypernephroid kidney cancer were checked; in this group operation and histological examination showed no kidney tumor. only in one patient we found the typical constellation with eleva ...200188402
cytochemical analysis on a case of familial 17ps.chromosome 17ps was identified in the mother and daughter but not the father of a normal family with no history of congenital abnormality. in addition to g-band and ag-nor staining, previously used to study this abnormality, we applied n-band and c-band techniques. our results showed that 17ps has no demonstrable ribosomal cistron or constitutive heterochromatin.197988409
localization of the nucleolar organizer by computer-aided analysis of a variant no. 21 in a human isolate.a variant chromosome no. 21 consisting of two stalks and two satellites in tandem was detected during a survey of a human isolate. the variant segregated in three generations of a large kindred. one male had the variant no. 21, a metacentric y, and a 47,xxy complement; however, no other evidence of chromosomal nondisjunction was found. computer-aided analysis of sequentially stained variant no. 21 chromosomes indicated that silver-stained material corresponded to the proximal stalk region (as de ...197988411
new concepts for pvc detection. 200188412
effect of norepinephrine on in vitro histamine release from rat mast cells.the effect of norepinephrine on compound 48/80-induced histamine release from rat peritoneal mast cells, was studied in an in vitro system. it was found that norepinephrine, within the concentration range 10(-5)--10(-3) m, exerts a significant, dose-related, repressive effect. this effect is greatly potentiated by the beta-antagonist practolol (10(-3) m), throughout the concentration range of 10(-11)--10(-3) m norepinephrine. methoxyamine, a selective alpha-adrenergic agonist, also represses his ...197988419
chromatographic studies of uremic plasma.in order to characterize the spectrum of possibly toxic retention compounds in uremia we have developed a simple reproducible method of separating fractions of uremic serum by sephadex g-15 column chromatography. this technique, which requires no prior deproteinisation and is carried out at ambient temperatures, allowed the separation of uremic serum into several well defined fractions. subsequent thin layer chromatography (tlc) showed that each peak represented a mixture of peptides, and that t ...200188420
genetic control of in vivo immunity to tumor-specific transplantation antigens of chemically induced murine fibrosarcomas. 200188423
the inhibitory effect of xanthine derivatives on alkaline phosphatase in the rat brain.histochemical and biochemical studies were carried out on the inhibition of alkaline phosphatase (a1-p) activity in rat cerebral cortex with various methylxanthine derivatives. the histochemical study revealed that a1-p activity was completely inhibited with 2 mm theophylline or aminophylline, only slightly inhibited with 5 mm of xanthine, and no way inhibited even with 5 mm of diprophylline or caffeine. the biochemical study showed that a1-p activity was markedly inhibited by 1 mm theophylline, ...197988432
a new selective ultrahistochemical method for the demonstration of calcium using n,n-naphthaloylhydroxylamine.a new, simple, rapid, and highly sensitive and selective method for the ultrahistochemical detection of calcium is described. the reagent n,n-naphthaloylhydroxylamine (1,8-c10h6con(ona)co) sodium salt was employed in this study for the demonstration of calcium at the subcellular level in relaxed and contracted muscles (smooth muscle of the stomach, thoracic aorta, and myocardial muscle cells) of the rat (in vitro as well as in vivo) and in the human vascular smooth muscle of the aorta with ather ...197988434
unorthodox fractionation in the treatment of head and neck tumors. 200188435
steroid receptor content in cytosol from normal and hyperplastic human prostates.analyses of steroid hormone receptors were performed using a dextran-coated charcoal technique in cytosolic preparations from 40 cases of benign prostatic hyperplasia (bph) and 10 normal human prostates. binding data were calculated according to scathchard. in all bph specimens, receptors for the synthetic androgen methyltrienolone (mt) were found (mean maximum number of binding sites, 566 fmol/mg dna; mean kd, 0.61 nm), and 25 of 28 samples contained progestin [17 alpha, 21-dimethyl-19-nor-4.8- ...197988456
a variant of the pyroantimonate technique suitable for localization of calcium in ovarian tissue.osmium-pyroantimonate solutions for the precipitation of cations are unsuitable for use with delicate mammalian oocytes. a variant of the pyroantimonate technique employing a mixture of pyroantimonate and glutaraldehyde has been found to give successful and repeatable results if a fixation time of 4 hr is used. calcium-containing antimonate precipitates were localized principally in nuclei, smooth endoplasmic reticulum, golgi apparatus, mitochondria, and cytoplasmic processes of both oocytes and ...200188471
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