Publications

[rhabdomyolysis, myoglobinemia and anuria in a bacterial airway infection].		1979	386143
[bacterial infections in renal homotransplant recipients. results of regular bacteriological controls (author's transl)].	bacterial infections were studied in 51 immunosuppression kidney transplant recipients. eighty infectious episodes occured in the first six post-transplantation months. forty percent of these episodes were nonfebrile, detected during the routine bacteriological follow-up examination. out of these 80 bacterial infections, 59 were localized (47 in the urinary tract, nine in the surgical wound and three in the lungs) and 21 had spread. neutopenia occured in 13 patients, in association with septicae ...	1979	386255
lung bacterial clearance following pulmonary contusion.	bacterial infections frequently,complicate pulmonary contusion and are the leading cause of death in such patients. this study evaluated the effects of pulmonary contusion alone and contusion associated with other factors on the ability to clear aerosolized bacteria from the lung. lung bacterial clearance of staphylococcus aureus and klebsiella pneumoniae was studied in animals with isolated pulmonary contusion, or contusion associated with blood loss, rapid crystalloid infusion, or steroid admi ...	1979	386541
changes in the incidence of necrotizing enterocolitis associated with variation of the gastrointestinal microflora in neonates.	the incidence of necrotizing enterocolitis was noted to vary in association with significant variation in the gastrointestinal microflora cultured from infants in the neonatal intensive care unit. increased colonization with e. coli and k. pneumoniae was associated with an increased incidence of necrotizing enterocolitis, which suggests that these organisms are related to the pathogenesis of necrotizing enterocolitis.	1979	386809
glucose uptake by klebsiella aerogenes. the role of the glucose-phosphoenolpyruvate phosphotransferase transport system [proceedings].		1979	386946
purification and properties of nitrogenase in ethylene glycol at sub-zero temperatures.	both the protein components kp1 and kp2 of nitrogenase from klebsiella pneumoniae were found to be stable in aq. 50% (v/v) ethylene glycol at +30 degrees c or below. at -20 degrees c in this medium their sensitivities to o2 were diminished somewhat. though purification could be carried out at -20 degrees c, the product had the same specific activity and was obtained in the same yield as when the purification was carried out by standard procedures. this suggests that such procedures yield enzyme ...	1979	387029
experimental klebsiella and salmonella infection in neonatal swine.	twenty colostrum-fed piglets from three sows were separated from the sows 24 hours after birth and were randomly divided into five groups of four piglets each. every piglet in each of four test groups was orally inoculated with about 10(10) colony forming units of salmonella typhimurium, salmonella choleraesuis var kunzendorf or one of two isolates of klebsiella pneumoniae. one group served as uninoculated controls. piglets infected with k. pneumoniae developed severe diarrhea beginning about 12 ...	1979	387185
current concepts of bacteremia in children with malignancies.	one hundred fifteen episodes of bacteremia occurred among 2790 children with malignancies hospitalized during a 45-month period. the mean age was 9.3 years with a male predilection (62%). a greater (p less than .025) number of children over 10 years of age died with bacteremia when compared to younger children. the majority of episodes occurred in children with leukemia (56%); however, once bacteremia developed, a significantly (p less than .05) greater number of children with lymphoma died when ...	1979	387211
requirements of immunoglobulin and the classical and alternative complement pathways for phagocytosis and intracellular killing of multiple strains of gram-negative aerobic bacilli.	the requirements for immunoglobulin and the alternative and classical complement pathways for phagocytosis and intracellular killing of clinical isolates of escherichia coli, proteus mirabilis, klebsiella pneumoniae, and serratia marcescens by normal human polymorphonuclear leukocytes were determined. human sera deficient in immunoglobulin or classical pathway activity, or both, were compared for their ability to promote phagocytosis os and killing of 13 bacterial strains by the polymorphonuclea ...	1979	387613
gentamicin for treatment of resistant urinary tract infections in dogs.	gentamicin was administered parenterally for 6 days to 43 dogs with urinary tract infections. the daily dosage of 6.6 mg/kg (3 mg/lb) was divided into equal parts and given im or sc at 8-hour intervals. dogs selected for treatment with gentamicin had urinary infections that had not responded to treatment with other antimicrobial agents or had bacterial isolates from urine that were resistant to several antimicrobial agents on in vitro susceptibility tests. response to treatment, defined as negat ...	1979	387689
an in vitro evaluation of clavulanic acid, a potent, broad-spectrum beta-lactamase inhibitor.	the in vitro efficacy of clavulanic acid, a new broad-spectrum inhibitor of enterobacterial beta-lactamases, was investigated. in conventional agar dilution tests, the presence of a sub-inhibitory level of clavulanic acid (8 microgram/ml) lowered the minimum inhibitory concentration of ampicillin for many resistant enterobacteria to therapeutically achievable levels. when tested against dense populations of escherichia coli and klebsiella strains in a static turbidimetric system and in an in vit ...	1979	387706
[laboratory and clinical studies on cefamandole (author's transl)].	the authors have carried out the laboratory and clinical studies of cefamandole (cmd). the results are as follows: the sensitivity was measured by plate dilution method on 26 strains of staphylococcus aureus, escherichia coli, klebsiella pneumoniae and 14 strains of salmonella typhimurium isolated from patients. the distribution of sensitivity of s. aureus was 0.39 approximately 3.13 micrograms/ml and the peak of distribution was 1.56 micrograms/ml. the distribution of sensitivity of e. coli was ...	1979	387993
effect of capsular polysaccharide of klebsiella pneumoniae on host resistance to bacterial infections. iii. further study of its effects on interactions between peritoneal leukocytes and virulent salmonella enteritidis.	the mechanism for the infection-promoting effect of the capsular polysaccharide of klebsiella pneumoniae (cps-k) was investigated using the experimental system in which mice were infected intraperitoneally (i.p.) with a virulent strain of salmonella enteritidis immediately after i.p. injection of cps-k. in the peritoneal phagocytes of cps-k-untreated control mice, approximately 70, 3, and 10% of phagocytized bacteria survived 6, 12, and 24 hr after challenge, respectively, when calculated from t ...	1979	388155
interferon and cytotoxic factor (cytotoxin) released in the blood of mice infected with mycobacterium bovis bcg. ii. influence of time after bcg inoculation on production of interferon and cytotoxin by capsular polysaccharide of klebsiella pneumoniae or by bacterial lipopolysaccharide and on hyperreactivity to their lethal effects.	the time course of the occurrence of hyperreactivity in interferon and cytotoxin responses to the active substance (neutral fraction) of the capsular polysaccharide of klebsiella pneumoniae (neutral cps-k) and bacterial lipopolysaccharide (lps) and of the hyperreactivity to their lethal effects was followed after infection with bcg in sma and icr strains of mice. the duration of these hyperreactivities of bcg-infected mice depended on the inoculum doses of bcg. the time patterns of the hyperreac ...	1979	388156
effect of capsular polysaccharide of klebsiella pneumoniae on host resistance to bacterial infections. iv. lack of inhibitory effect on intracellular digestion of chicken erythrocytes by mouse peritoneal macrophages.		1979	388157
a transposon, tn732, encoding gentamicin/tobramycin resistance.	gentamicin and tobramycin are important antibiotics in the treatment of hospital infections because of their activity against a wide range of bacterial genera. with their increasing use, bacteria resistant to these drugs have appeared, the resistance being frequently plasmid determined. the resistance genes determine various enzymes that modify and inactivate the drugs and there is association between particular gentamicin/tobramycin resistance genes and plasmids of particular groups, implying t ...	1979	388234
defective activation of the third component of complement in the sera of newborn infants.	the activation of the terminal complement components, c3--9, plays an important role in the host's defense against infection. in the present study, the ability of bacteria to activate the third component of complement (c3) in newborn serum was examined. a variety of bacteria were incubated in test sera at 37 degrees c for 30 min and the percent of available c3 that was activated was measured. using one strain of escherchia coli (no. 3), 32% (mean) of the available c3 was activated in sera from 1 ...	1979	388331
[new antibiotics].		1979	388886
microflora of the human small intestine.	the human small intestine is normally sterile in nearly one half of north american subjects. in this study the duodenum, jejunum, and ileum were sterile in 82, 69, and 55 per cent of the cases, respectively. gram-positive cocci were the most frequent finding. e. coli, enterobacter, and klebsiella were present in the small bowel in nearly 7, 15, and 35 per cent of duodenal, jejunal, and ileal samples, respecatively. they were present in significant numbers (greater than 1 x 10(5)/ml) in the mid-j ...	1979	389076
australian evaluation of autobac i with suggested interpretive and technical modifications.	autobac i, a recently introduced semiautomated method for rapid antibiotic susceptibility testing, has been evaluated by comparison with the calibrated dichotomous sensitivity disk diffusion technique, which is routinely used in many australian hospitals. only the most common clinical isolates, staphylococcus aureus, escherichia coli, klebsiella sp., and proteus mirabilis, were included in this evaluation, and an overall interpretive agreement of 93% was obtained. however, an unusually high rate ...	1979	389157
netilmicin in the treatment of infections in patients with cancer.	ninety-two patients with cancer with 100 infectious episodes were treated with netilmicin sulfate, a new aminoglycoside. netilmicin was administered intravenously, either intermittently or by continuous infusion. the overall cure rate was 60%. gram-negative bacilli were the most common causative organisms and the response rate for these infections was 32/53 (60%). the most common pathogens were escherichia coli, klebsiella pneumoniae, and pseudomonas aeruginosa. pneumonia, urinary tract infectio ...	1979	389189
bacteriological study of diarrhoea in infancy and childhood (part i).		1979	389801
[antibacterial activity of cefotaxim in comparison with seven cephalosporins].	the antibacterial activity of cefotaxim and seven cephalosporins was determined in 1,112 fresh isolates using the microdilution technique. all of the cephalosporins tested were ineffective against enterococci. cefalotin was the most effective agent against staphylococcus aureus. cefaclor was superior to cephalexin against escherichia coli and proteus mirabilis, and thus inhibited 20% more enterobacteriaceae. cefazolin was as effective as cefamandole against e. coli. cefuroxime and cefoxitin were ...	1979	389804
in vitro comparison of synergism between cefamandole and gentamicin or tobramycin by the triple layer agar method with enzymatic inactivation.	a synergistic effect was shown with gentamicin and tobramycin by means of a triple layer agar technique and enzymatic inactivation of cefamandole after only four hours' incubation. when the strain is sensitive to cefamandole and aminoglycosides, synergy is observed against all the strains studied (staphylococcus aureus, proteus, klebsiella, escherichia coli, enterobacter, and haemophilus influenzae). no significant difference was noted between the cefamandole-tobramycin and the cefamandole-genta ...	1979	389805
in vitro investigations with fosfomycin on mueller-hinton agar with and without glucose-6-phosphate.	determination of the minimal inhibitory concentration of fosfomycin in the agar dilution test on mueller-hinton agar showed that the addition of glucose-6-phosphate to the nutrient medium potentiates the action of fosfomycin against escherichia coli, klebsiella, enterobacter, citrobacter and staphylococcus aureus, sometimes by as much as 256-fold. such a potentiation of action was not detectable with serratia marcescens, the individual proteus species, pseudomonas aeruginosa or enterococci. fosf ...	1979	389806
synergistic activity of co-trimazine and co-trimoxazole in the urine.	co-trimazine (sulphadiazine, 410 mg + trimethoprim, 90 mg) is a new drug combination developed especially for use in the treatment of urinary tract infections. in cross-over experiments in volunteers receiving daily doses of co-trimazine (2 x 500 mg and 1 x 1000 mg), co-trimoxazole (2x960 mg), or nitrofurantoin (3x50 mg), the degree of antibacterial activity of co-trimazine in the urine was at least as high as that of co-trimoxazole and much higher and more consistent than that of nitrofurantoin ...	1979	389809
efficacy of two trimethoprim-sulphonamide combinations in experimental pyelonephritis in the rat.	co-trimazine, a new combination of trimethoprim and sulphadiazine intended for treatment of urinary tract infections, was tested and compared to co-trimoxazole in an experimental model of acute, obstructive pyelonephritis in the rat. the tests were carried out at four dose levels corresponding to the clinically recommended doses and to 1/4, 1/2, and 3/4 of the latter. the drugs were administered orally. co-trimazine was found to have a greater antibacterial activity than co-trimoxazole and its u ...	1979	389811
development of sulphonamide-trimethoprim combinations for urinary tract infections. part i: comparison of the antibacterial effect of sulphonamides alone and in combination with trimethoprim.	plasma half life and in vitro activity were major criteria for selection of sulphonamides which are likely to give a strong synergistic action with trimethoprim in vivo. on the basis of literature data six sulphonamides, sulphadiazine, sulphachloropyridazine, sulphamethoxazole, sulphaisodimidine, sulphamerazine and sulphamethomidine appeared particularly suitable for combination with trimethoprim. an investigation of the activity in vitro of these compounds and their combinations with the latter ...	1979	389812
biotypes of klebsiella pneumoniae (sensu lato) and enterobacter aerogenes characterised by differential substrate metabolism: application of the technique.	a biochemical typing method is described for klebsiella pneumoniae (sensu lato) and enterobacter aerogenes. the technique depends on differences in metabolism of five carbon substrates--glycerol, inositol, lactose, glucose, and xylose--at two concentrations. reproducibility is satisfactory and is monitored by the incorporation of control klebsiellae of known biotype. the method has been used for 12 months in the surveillance of urinary tract colonisation in this hospital. gut carriage of klebsie ...	1979	389960
further studies on the sources of klebsiella aerogenes in hospital patients.	we report an investigation into faecal carriage of klebsiella aerogenes and the distribution of this organism in the environment of three wards. in all three wards faecal carriage rates were high (60-70%). the faecal carriage rate increased with antibiotic administration and with length of in-patient stay. k. aerogenes was widely distributed in the ward environment and was found on the hands of nursing staff. clusters of isolations of k. aerogenes of the same serotype were demonstrated indicatin ...	1979	390043
effect of antibiotics on the adherence of enterobacteriaceae to human buccal cells.	antibiotics at bacteriostatic concentrations (four times the minimal inhibitory concentration) decreased the attachment of enterobacteriaceae to human buccal cells in vitro and augmented the reversibility of such adherence. these actions of antibiotics may influence colonization by nosocomial bacteria and the subsequent infection that they cause.	1979	390065
comparison of techniques for measurement of in vitro antibiotic synergism.	the methods and criteria for testing for synergy were compared with use of 22 strains of klebsiella pneumoniae and a combination of cephalothin and gentamicin. with the checkerboard technique, the frequency of synergy varied depending on the criterion employed. when the rate of killing of bacteria by antibiotics was measured, results varied depending on the size of inoculum. when the checkerboard and killing-curve techniques were compared, there was poor correlation in terms of the frequency of ...	1979	390067
transmission and scanning electron microscopic studies of rhinoscleroma.	using both types of electron microscope, combined transmission and scanning electron microscopic studies were done on 6 patients with rhinoscleroma. the present work suggests the possibility of two types of organisms causing the disease: one type--being in the majority--was a rod-shaped bacillus measuring about 3 micrometers; the other type was a short, stout bacillus with terminal spiral cilia. the ultrastructure of these bacilli has been described. the advantages and limitations of each type o ...	1979	390072
[protein study of klebsiella rhinoscleromatis deoxyribonucleoprotein].		1979	390327
bacteriologic considerations in perforated necrotizing enterocolitis.	during a ten-year period, 61 infants with perforated necrotizing enterocolitis were managed by bowel resection, enterostomy, and intravenous antibiotics. aerobic and anaerobic cultures were taken of venous blood, from the peritoneal cavity at operation, and of any subsequent wound and/or intraperitoneal infection. no significant differences between fatal and nonfatal cases were noted with respect to presence of anaerobes in the peritoneal flora (six babies with two deaths) or culture-confirmed b ...	1979	390716
the pathology of human cardiac transplantation: an assessment after 11 years' experience at groote schuur hospital.	over a period of 11 years, commencing in december 1967, 31 cardiac transplants, 10 orthotopic and 21 heterotopic, were performed at groote schuur hospital. two patients with orthotopic transplants have a long survival, 1 for 7 1/2 and 1 for 9 1/2 years, and 1 with a heterotopic transplant for 4 years. eighteen patients have died, and autopsy was performed from 13 to 623 days postoperatively. rejection of the donor heart was found in 61,1% and was the cause of death in 44,4% of cases. infection, ...	1979	390737
[an 'outbreak' of klebsiella mastitis].		1979	390764
["in vitro" and "in vivo" antibacterial activity of a new synthetic antibiotic cinoxacin].	the authors have conducted the experimental studies tending to valuate the antibacterial activity in vitro and in vivo of cinoxacin versus that demonstrated by nalidixic acid. the obtained results demonstrate the cinoxacin presents a similar antibacterial activity to that of nalidixic acid.	1979	391252
[criteria for the determination of fecal enterobacteria].		1979	391651
plasma specific gravity and haematocrit values as indices of the degree of dehydration in infantile diarrhoea.		1979	391710
the nature of the genetic determinant for the shv-1 beta-lactamase.	in two unrelated plasmids of incompatibility groups fii and n the gene for the shv-1 beta-lactamase exists as part of a transposable element of molecular weight 9.5 megadaltons. this transposon has moved onto plasmids of at least three incompatibility groups; pi, ialpha and j. this confirms the suggestion that the recent spread of the shv-1 beta-lactamase has been associated with the transposition of the genetic determinant of this enzyme between unrelated plasmids.	1979	392225
update on non hospital-acquired pneumonias.		1979	392574
[betel chewing and its action upon the bacterial flora].		1979	393086
effect of long-term tetracycline exposure (drinking water additive) on antibiotic-resistance of aerobic gram-negative intestinal flora of rats.	a study was undertaken to determine the effect of 2 years of intermittent administration of tetracycline in drinking water on antibiotic resistance in the aerobic gram-negative enterobacteria of rats in a closed colony. the bacterial isolates examined were resistant to tetracycline and streptomycin. minimal inhibitory concentrations of tetracycline and streptomycin for intestinal organisms were similar in all of the animals, regardless of whether the animals were sampled while they were given dr ...	1979	393143
a study of klebsiella pneumoniae infection in the uterus of the mare.	two experiments incorporating 13 mares were conducted for the purpose of producing and monitoring intrauterine infection with klebsiella pneumoniae. in the pilot study, the infection was produced with strains of k pneumoniae type 68 and type 10 isolated from the genital tract of stallions with a history of breeding problems. in the principal study, k pneumoniae type 68 was used to produce the infection. tampons and guarded culture swabs were used to obtain uterine samples in the pilot study. in ...	1979	393145
temperature control of nitrogen fixation in klebsiella pneumoniae.	at growth temperatures above 37 degrees c, klebsiella pneumoniae does not grow in a medium containing n2 or no3- as nitrogen sources. however, both the growth in the presence of other nitrogen sources as well as the in vitro nitrogenase activity are not affected at this temperature. the inability to fix n2 at high temperature is due to the failure of the cells to synthesize nitrogenase and other nitrogen fixation (nif) gene encoded proteins. when cells grown under nitrogen fixing conditions at 3 ...	1979	393199
purification and properties of klebsiella aerogenes d-arabitol dehydrogenase.	an escherichia coli k12 strain was constructed that synthesized elevated quantities of klebsiella aerogenes d-arabitol dehydrogenase; the enzyme accounted for about 5% of the soluble protein in this strain. some 280 mg of enzyme was purified from 180 g of cell paste. the purified enzyme was active as a monomer of 46,000 mol.wt. the amino acid composition and kinetic constants of the enzyme for d-arabitol and d-mannitol are reported. the apparent km for d-mannitol was more than 3-fold that for d- ...	1979	393250
benzene from bacterial cleavage of the carbon-phosphorus bond of phenylphosphonates.	an organism, identified as a strain of klebsiella pneumoniae, was proved by direct assay to utilize ionic methyl phenylphosphonate as sole phosphorus source. one product from c-p-bond cleavage was identified as benzene by combined g.l.c.-mass spectrometry. the molar yield of benzene from the phosphonate was 89%.	1979	393257
physiological characteristic and energy balance of klebsiella aerogenes in a multistage tower fermentor.	biomass growth, consumption of carbon and energy source, specific rates of formation of metabolic byproducts, biomass yield referred to the c-source and to oxygen, respiration rate and the value of rq were studied in klebsiella aerogenes ccm 2318 (on a synthetic glucose medium) at different specific growth rates. maintenance coefficients and the total energy balance of the cultivation process were evaluated for a multistage tower fermentor with a defined interstage mixing. the results pointed to ...	1979	393594
indirect sandwich enzyme-linked immunosorbent assay for rapid detection of haemophilus influenzae type b infection.	we report the development and testing of an enzyme-linked immunosorbent assay with excellent sensitivity for the detection of haemophilus influenzae type b (hi(b)) antigen in clinical specimens from patients with hi(b) meningitis. the assay, an indirect sandwich technique, uses polystyrene balls as a solid phase and an alkaline phosphatase-labeled goat anti-rabbit globulin conjugate. specimens are incubated with polystyrene balls armed with burro anti-hi(b) antiserum, and recognition antibody is ...	1979	393714
taxonomic position of klebsiella atlantae and klebsiella edwardsii.	the taxonomic position of two species of the genus klebsiella (k. atlantae and k. edwardsii) is being introduced. 211 strains of different origin were studied: 80 strains of k. pneumoniae, 46 strains of k. oxytoca, 50 strains of k. atlantae and 35 strains of k. edwardsii. sixty biochemical characteristics were determined 40 of these pertaining to carbohydrate metabolism. it was discussed whether both are to be considered species or biotypes of another klebsiella species, however, by determining ...	1979	393774
subtraction serum bactericidal assay: a method for estimating in vivo effects of antibiotic combinations.	the subtraction serum bactericidal assay has been developed to assess the effects of the individual components of antibiotic combinations in serum specimens from patients with serious bacterial infection. the technique can be performed easily with conventional microtiter technology, and the results compare favorably with those obtained by conventional in vitro determinations of the additive and synergistic activity of fixed antibiotic combinations against various enterobacteriaceae. three combin ...	1979	393780
a clinical approach to the choice of antimicrobial usage, case number eight: klebsiella pneumoniae pneumonia.		1979	393786
a study in evolution: the histidine utilization genes of enteric bacteria.		1979	393834
[laboratory and clinical studies on cefuroxime (author's transl)].	the authors have carried out the laboratory and clinical studies of cefuroxime (cxm). the results were as follows: the sensitivity was measured by plate dilution method on 26 strains of s. aureus, 22 strains of e. coli and 24 strains of k. pneumoniae isolated from patients. the distribution of sensitivity of s. aureus was 0.78 approximately 3.13 micrograms/ml and the peak of distribution was 1.56 micrograms/ml. the distribution of sensitivity of e. coli was 1.56 approximately 50 micrograms/ml an ...	1979	393845
[fundamental and clinical studies on cefuroxime in children (author's transl)].		1979	393846
prostaglandin formation in bacteria.	we report here that intact gram positive and gram negative bacteria, in the presence of exogenous arachidonic acid, produce and release pge2 and pgf2 alpha into the medium as measured by radioimmunoassay. the seven bacterial strains so far studied release 6.5-50.9 ng pge2 and less than 0.02-0.51 ng pgf2 alpha per mg bacterial protein during a 1 hour incubation, quantities of the same order of magnitude as those observed in mammalian systems. pge2 and pgf2 alpha formation in bacteria are inhibite ...	1979	394198
comparison of m-endo les, macconkey, and teepol media for membrane filtration counting of total coliform bacteria in water.	total coliform counts obtained by means of standard membrane filtration techniques, using macconkey agar, m-endo les agar, teepol agar, and pads saturated with teepol broth as growth media, were compared. various combinations of these media were used in tests on 490 samples of river water and city wastewater after different stages of conventional purification and reclamation processes including lime treatment, and filtration, active carbon treatment, ozonation, and chlorination. endo agar yielde ...	1979	394678
nitrogen fixation associated with 'park' kentucky bluegrass (poa pratensis l.).	associative nitrogen fixation in kentucky bluegrass (poa pratensis l.) turfs inoculated with five nitrogen-fixing bacterial isolates was evaluated using the acetylene reduction assay and nitrogen accumulation as indicators of fixation. 'park' and 'nugget' kentucky bluegrass turfs were grown in controlled environment chambers and inoculated with klebsiella pneumoniae (w-2, w-6, and w-14), erwinia herbicola (w-8), and enterobacter cloacae (w-11). 'park' inoculated with k. pneumoniae (w-6) had sign ...	1979	394819
case reports: klebsiella pneumonia.		1979	394893
r-plasmid linked lactose fermentation in klebsiella pneumoniae.		1979	395110
some observations of chronic diarrhoea--laboratory, radiological and histological study (part ii).		1979	395112
klebsiella pneumoniae: in vitro antibacterial activity of cefoxitin and amikacin, alone and in combination.		1979	395157
[bactericidal activity of aminosides in a static system and in a dynamic model].		1979	395504
[recent acquisitions concerning pathogenic enterobacteria].	a subdivision of enterobacteria is made into classic pathogens and saprophytic species which become opportunistic agents of various syndromes. after a review of the epidemiological situation in central italy regarding salmonellosis and shigellosis, an analysis of the e. coli types involved in the enteritis syndromes is carried out. other topics discussed in the article are the sistemic infections by serratia, kelbsiella, enterobacter and proteus strains; moreover the causative agents of urinary ...	1978	395563
[etiology of neonatal bacterial infections].		1979	395579
[blood exchange transfusion in severe infections in the newborn infant].		1979	395580
sickle cell trait and bacteriuria during pregnancy.		1979	395794
[coliforms in water: definition and discussion of analytical methods].		1979	395908
energy requirement for maintenance of the transmembrane potassium gradient in klebsiella aerogenes nctc 418: a continuous culture study.	with a glucose-limited culture of klebsiella aerogenes, growing at a fixed dilution rate (0.4 h-1), the specific respiration rate varied progressively as a function of the transmembrane k+ gradient. the latter was varied by changing the input k+ concentration and, under these conditions, the specific respiration rate was linearly related to the electrochemical potential of the k+ gradient. increasing or decreasing the transmembrane k+ gradient in putatively potassium-limited cultures elicited ma ...	1979	395915
influence of the glucose input concentration on the kinetics of metabolic production by klebsiella aerogenes nctc 418: growing in chemostat culture in potassium- or ammonia-limited environments.	with chemostat cultures of klebsiella aerogenes growing at a fixed dilution rate, initially under conditions of glucose-limitation, transition to either potassium-limitation or ammonia-limitation was found not to be a steep step function. a wide range of intermediate steady states could be established in which neither substrate was present in excess of the growth requirement. as the molar ratio of glucose: k+ in the feed medium was progressively increased, the additional glucose carbon was first ...	1979	395916
bacteriological mycological and parasitological study in childhood diarrhoeas in bikaner (western rajasthan).		1979	396251
comparative bactericidal effect of ceforanide (bl-s 786) and five other cephalosporins in an in vitro pharmacokinetic model.	the bactericidal activity of ceforanide was compared, in an in vitro kinetic model, with that of five other cephalosproins: cephalothin, cefazolin, cefamandole, cefuroxime, and cefoxitin. cultures of various pathogens in 95% human serum were incubated for 12 hours in the presence of the cephalosporins whose concentrations were modified periodically-by addition of a concentrated solution of drug or dilution with unmedicated serum-in order to simulate the variation of antibiotic concentration in h ...	1979	396292
adjuvant action of capsular polysaccharide of klebsiella pneumoniae on antibody response. vii. further purification of the active substance.		1979	396462
[blood exchange in klebsiella pneumoniae septicemia. apropos of a case in an infant].		1979	396607
epidemiology of klebsiella and hospital-associated infections.		1979	396632
[influence of glucose-6-phosphate and inorganic phosphate on the resistance of klebsiella species and e. coli towards fosfomycin (author's transl)].		1979	396739
[differentiation of klebsiella pneumoniae variatio "oxytoca" (author's transl)].	altogether 268 strains of klebsiella were investigated with respect to their ability to ferment dulcitol and to produce indole, gelatinase, and brown pigment on a medium containing gluconate and ferric citrate. in addition the capacity of the strains to use m-hydroxybenzoic acid as sole source of carbon and energy was tested. of the 83 indole-positive klebsiella strains 72 (87%) were able to grow on the m-hydroxybenzoic acid medium, whereas only 2 (1%) of the indole-negative strains did so. late ...	1979	396740
microcalorimetry studies of energy changes during the growth of klebsiella aerogenes in simple salts/glucose media. 1 establishment of standard conditions.	the shape of the thermogram and the total heat output of aerobically growing cultures of klebsiella aerogenes depend on the nature and state of the inoculum, the composition of the growth medium, aeration in the fermentor and in the calorimeter, and the pump rate of the culture through the microcalorimeter cell. standard conditions of growth and heat measurement have been established which give reproducible thermograms and total heat output. experimental results using different glucose concentra ...	1979	397402
complement activation in pneumonia.	complement analyses performed on serially collected plasma samples from 10 patients during acute infectious pneumonia or bronchopneumonia showed normal or increased values for hemolytic activity and clq, c4, c3, and factor b levels. however, the levels of c3 breakdown products (c3d) were significantly (greater than 2 sd) increased in six patients during the first three days of observation, suggesting that hypercatabolism of complement components may occur during the acute phase of infectious pne ...	1979	397408
antigenic similarity of morphologic type ciii1 bacteriophages.		1979	397728
the spleen in sickle cell disease and thalassemia.		1979	397779
[bacteriocinotyping of klebsiella. a new scheme (author's transl)].	a new typing scheme of the genus klebsiella for studying the production and different sensitivities towards some standard strains is here proposed. owing to it, 120 klebsiellae could be classified. the most frequently bacteriocinotypes found were 778 and 768. the overall amount obtained was of 57 different models of activity. as six clinical experiences have confirmed its efficacy, the practical use may now be faced.	1979	398164
a comparison of the in vitro activity of a new cephalosporin, cefuroxime, and cephalothin against 810 clinical isolates.	810 strains of eight species: staphylococcus aureus, staphylococcus epidermidis, streptococcus faecalis, escherichia coli, klebsiella sp, enterobacter sp, proteus mirabilis and proteus vulgaris, were tested by the disc diffusion method against cephalothin and cefuroxime. the activity of the two drugs was comparable to s aureus and s epidermidis, and a little in favour of cefuroxime regarding s faecalis. cefuroxime turned out to be superior to cephalothin against the gram negative rods investigat ...	1979	398460
comparison of cefaclor and amoxycillin in the treatment of urinary infections in a chronic disease hospital.	the clinical efficacy and safety of cefaclor, a new oral cephalosporin, was compared with that of amoxycillin in the treatment of lower urinary tract infections in 61 patients with chronic non-urinary tract disease. thirty-six patients received cefaclor and 25 received amoxycillin doses of 250 mg every 8 hours for 7 to 10 days. the therapeutic effectiveness of cefaclor was significantly better than that of amoxycillin, and it appeared to be well tolerated and free of adverse side effects. it pro ...	1979	398483
laboratory and clinical studies of cefaclor in japan.		1979	398486
role of environmental factors in uveitis.	as part of a larger study undertaken to determine whether the presence of faecal klebsiella aerogenes was significantly associated with the clinical activity of ankylosing spondylitis, thirteen patients with ankylosing spondylitis and acute non-granulomatous anterior uveitis (angau) were examined. the faeces of eleven of these thirteen patients were found to contain klebsiella aerogenes. this association shows a statistical significance of p less than 0.01, and suggests that klebsiella aerogenes ...	1979	398604
[resistance of gram-negative bacteria against cefaclor and other antibiotics (author's transl)].	five hundred and eighty-six strains of eight species of enterobacteriaceae were tested for their resistance against cefaclor, cefamandole, cephalothin, ampicillin, mezocillin, tetracycline and co-trimoxazole. cefaclor showed a low rate of resistance against escherichia coli (1.2%), klebsiella (2%) and proteus mirabilis (3.1%), but a high rate of resistance against indole-positive proteus species (60%) and serratia (80%). cefamandole was also effective against cefaclor and ampicillin resistant st ...	1979	399243
[the antibacterial efficacy of cefaclor against bacteria resistant to ampicillin, tetracycline and co-trimoxazole (author's transl)].	the antibacterial activity of the new oral cephalosporin cefaclor was investigated using 623 freshly isolated bacterial strains. a high degree of efficacy of cefaclor was noticed against escherichia coli, proteus mirabilis and klebsiella. nearly all strains which were sensitive to ampicillin, tetracycline and co-trimoxazole were also inhibited by cefaclor. some of the strains resistant to the three above-mentioned antibiotics were also sensitive to cefaclor as follows: all of ten p. mirabilis st ...	1979	399244
[subinhibitory activity of cefaclor and cephalexin (author's transl)].	the determination of the minimal inhibitory concentration (mic), which is usually performed after 18 to 24 hours of incubation, results in the case of cefaclor in a false picture of the actual activity. cefaclor is chemically so unstable that after 24 hours only 2-5% of the substance is microbiologically active. in order to compare the activity of cefaclor and cephalexin, the effect of subinhibitory concentrations of both antibiotics against escherichia coli and klebsiella pneumoniae strains was ...	1979	399246
[influence of cefaclor on experimental pyelonephritis (author's transl)].	a comparative study on the antibiotic activity of cefaclor and cephradine was performed in an infection and therapy model of acute pyelonephritis in the rat. pathogens were escherichia coli and klebsiella pneumoniae. the antibiotics, which were administered orally, both had a pronounced effect in comparison to the untreated control group. cefaclor was superior to cephradine in infections caused by k. pneumoniae.	1979	399249
evidence for a specific b27-associated cell surface marker on lymphocytes of patients with ankylosing spondylitis.		1979	399656
[studies in the balb/c mouse of the efficiency of spraying as compared to other inoculation ways for immunostimulant (author's transl)].	the of efficiency of spraying as compared to intranasal and digestive ways was tested on balb/c mouse by using on the one hand an immunostimulant product and on the other various types of test : myxovirus influenzae by aerosol, streptococcus pyogenes intranasally, klebsiella pneumoniae intraperitoneally. results showed that in the case of influenza virus the immunostimulant inhaled as liquid aerosol or powder aerosol, or deposited on the nasal mucosa was very active. when the test germ was strep ...	1979	400026
[researches on some biochemical and serological properties and on the sensitivity to antibiotics of l-forms of "proteus" (author's transl)].	the possibility to keep some biochemical reactions of the parent strains (urease-positive, glucose fermentation, phenylalanine-deaminase-positive, h2s but not indol production) was demonstrated in 5 l-forms, obtained from as many strains of pr. mirabilis and in 1 l-form, isolated from a vaginal secretion and identified as belonging to the same species. the indirect hemagglutination technique, made by the sonicated antigen in 3 of the 6 l-forms with proteus oxk antiserum, resulted positive in tit ...	1979	400087
[the sulfamethoxazole-trimethoprim combination 1st survey into its in vitro activity in brazzaville, congo results of 780 bacterial strains isolated at the national laboratory and the general hospital in a single year].	the combination of smz-tmp has recently been introduced in congo. this year (1978), it is very used by many physicians. to help the congolese physicians working without antibiogram frequently, we have tested 780 strains from august 1977 to august 78. the susceptibility of these strains was: for e. coli 90%, klebsiella 69,20%, staphylococcus 93% and for all strains studied gram + and gram - the percentage was 75,51. as many authors have showed, the strains of pseudomonas, streptococcus faecalis a ...	1979	400121
r-factor mediated gentamicin resistance in "klebsiella aerogenes". a new problem in nosocomial infection.		1979	400250
[bacterial resistance in the infections from gram-negative bacilli in a long-term hospital (author's transl)].	after considering the different reasons that make the problem of bacterial resistance of gram-negative bacilli to antibiotics of great interest in a long-term hospital, the aa. present their cases. they point out how the strains isolated by them offer an antibiotic resistance which is decidedly superior to the one described in other researches. one thing seems to be noteworthy in their opinion: the bacterial resistance of the germs isolated from the urine is bigger than the one of the germs isol ...	1979	400255
stepwise selection of defective nitrogen-fixing phenotypes in escherichia coli k-12 by dimethyl sulfoxide.	storage in dimethyl sulfoxide of escherichia coli k-12 hybrids carrying klebsiella pneumoniae nif+ genes can result in selection of a defective nitrogen-fixing phenotype. dimethyl sulfoxide appears to affect particular inner membrane proteins associated with energy metabolism in e. coli k-12.	1977	400799
in vitro and in vivo studies with bl-s786, cefoxitin, and cefamandole.	the in vitro antimicrobial activities of bl-s786, cefoxitin, and cefamandole against 90 isolates of enterobacteriaceae, including escherichia coli, klebsiella pneumoniae, proteus mirabilis, enterobacter cloacae and e. aerogenes, were studied by using an agar dilution procedure. comparison of geometric mean minimal inhibitory concentrations showed that bl-s786 was half as active as cefamandole against enterobacter species, 2 to 4 times more active than cefamandole against all other species, and 4 ...	1978	400821
in vitro antimicrobial activity of some cyclic hydroxamic acids and related lactams.	against enterobacter aerogenes 13048, serratia marcescens 13880, klebsiella pneumoniae 10031, pseudomonas aeruginosa 10145, escherichia coli 9723, lactobacillus casei 7469, lactobacillus plantarum 8014, leuconostoc dextranicum 8086, and streptococcus faecalis 8043, the mean minimal inhibitory concentrations of three cyclic hydroxamic acids, 3-amino-3,4-dihydro-1-hydroxycarbostyril, the 6-chloro analog, and the 7-chloro analog, were 0.6, 0.6, and 0.2 micrograms/ml, and those of the corresponding ...	1978	400828