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a study of the spirochaeticidal action of the serum of patients treated with salvarsan.1. the serum of rabbits treated intravenously with neosalvarsan, and of syphilitic patients treated intravenously with salvarsan or neosalvarsan, has a definite spirochaeticidal action upon spirochoeta duttoni. 2. although this spirochaeticidal action is exerted in vitro, it can be demonstrated only after the treated spirochaetae are injected into susceptible animals. 3. a curative action of the serum of neosalvarsan-treated rabbits is exercised on mice infected with spirochoeta duttoni. 4. the ...191319867719
observations on a strain of spirochaeta pallida isolated from the nervous system.a strain of spirochoeta pallida isolated from the nervous system has shown the following constant characters: (1) thick form; (2) the production of hard, well demarcated lesions with necrotic centers; (3) a characteristic location of the lesion; (4) a short incubation period; (5) a tendency to generalize with lesions of the skin and eye, following local inoculation of the testicle and scrotum. it is suggested that these characters constitute a definite strain of highly invasive power and that a ...191419867775
a pathological study of syphilitic aortitis and its serology.1. syphilitic aortitis is a productive inflammatory process, the earliest and most constant feature of which is a perivascular round cell infiltration in the adventitia. 2. the typical gross picture of luetic aortitis is often obscured by a superimposed, diffuse atherosclerosis. in the early cases the aorta appears fairly normal, presenting only the characteristic histological changes. 3. a pure aortic insufficient valve, with the exception of an infectious endocarditis, is always luetic. 4. car ...191619867969
the pure cultivation of spirochaeta icterohaemorrhagiae (inada).pure cultures of the spirochaetal causative agent of the disease known as weil's disease, or febrile icterus, in japan, have been obtained by us in a solid, a semisolid, and a fluid medium. the spirochaeta thus isolated remains pathogenic for guinea pigs for many generations. up to the present time we have succeeded through the courtesy of professor nagayo, dr. konuma, and dr. ishihara, in cultivating three different strains. the spirochaeta is a facultative anaerobe. the solid and semisolid cul ...191619868006
the prophylaxis of weil's disease (spirochaetosis icterohaemorrhagica).we have already described briefly the portals of entry and of excretion of the pathogenic spirochetes. we may mention here that we have twice prevented epidemics by disinfection of the ground and the removal of the inundated water in certain places in coal mines. in one mine 19 out of 50 workmen, and in another 9 out of 30 workmen came down with weil's disease in about 2 weeks. we have already pointed out that the period during which the pathogenic spirochetes are excreted in the urine continues ...191619868055
the serum treatment of weil's disease (spirochaetosis icterohaemorrhagica).horses immunized with cultures of spirochaeta icterohaemorrhagiae yield an immune serum having therapeutic properties. with rare exceptions the serum destroys completely the spirochetes contained in the circulating blood. the development of antibodies is promoted by the serum injections. the number of spirochetes in the organs is reduced by the treatment. secondary manifestations due to the serum are slight and disappear promptly. the ultimate effects of the serum treatment on the symptoms and f ...191619868056
spirochaeta morsus muris, n.sp., the cause of rat-bite fever : second paper.1. since our first report on the discovery of the cause of rat-bite fever, we have been able to prove the existence of the same spirochete in five out of six more cases which have come under our observation. 2. the clinical symptoms of rat-bite fever are inflammation of the bitten parts, paroxysms of fever of the relapsing type, swelling of the lymph glands, and eruption of the skin, all occurring after an incubation period usually of from 10 to 22 days, or longer. 3. our spirochete is present i ...191719868077
the drug-fastness of spirochetes to arsenic, mercurial, and iodide compounds in vitro.in the foregoing experiments we attempted to determine whether or not, by subjecting several varieties of spirochetes to increasing doses of certain chemotherapeutic agents, a gradual increase of resistance to the latter could be shown. for this purpose, pure cultures of treponema pallidum, treponema microdentium, and spirochoeta refringens were used against the action of salvarsan, neosalvarsan, bichloride of mercury, and iodine-iodide potassium solution in vitro. for culture media, the usual a ...191719868093
spirochaeta icterohaemorrhagiae in american wild rats and its relation to the japanese and european strains : first paper.the principal points brought out in the present article are the following. 1. wild rats captured in this country carry in their kidneys a spirochete which possesses the morphological and pathogenic properties characteristic of spirochata icterohamorrhagia discovered by inada in the japanese form of infectious jaundice. 2. cultures of the american, belgian, and japanese strains of the spirochete were obtained by a special technique described, the first two strains having been cultivated artificia ...191719868121
cultivation of spirochaeta obermeieri. 191719868132
the distribution in the human body of spirochaeta icterohaemorrhagiae. 191719868152
the rat as a carrier of spirochaeta icterohaemorrhagiae, the causative agent of weil's disease (spirochaetosis icterohaemorrhagica).1. on the basis of these findings, we conclude that the extermination of rats and field mice is a highly important prophylactic measure against weil's disease. 2. the chemical composition of soil and water plays animportant part in the development of spirochoeta icterohoemorrhagioe, and consequently in the spread of the disease of which it is the causative agent.191719868153
distribution of spirochaeta icterohaemorrhagiae in the organs after intravenous serum treatment.on the basis of these findings we believe that we are justified in saying that the immune serum of weil's disease is capable of destroying the spirochetes found within the organs in man, with the exception of the kidneys, and that the action of the serum upon the spirochetes is spirochetolytic and spirocheticidal. the scattered spirochetes in the kidney, on the other hand, are resistant to the action of the immune serum. the spirochetes disappear almost completely from the organs during the conv ...191819868206
morphological characteristics and nomenclature of leptospira (spirochaeta) icterohaemorrhagiae (inada and ido).the present study deals with the morphology and systematic position of the causative agent of infectious jaundice. there are several features which are not found in any of the hitherto known genera of spirochaetoidea which led me to give this organism an independent generic name, leptospira, denoting the peculiar minute elementary spirals running throughout the body. the absence of a definite terminal flagellum or any flagella, and the remarkable flexibility of the terminal or caudal portion of ...191819868227
further study on the cultural conditions of leptospira (spirochaeta) icterohaemorrhagiae.1. the presence of suitable animal or human serum is essential for the cultivation of leptospira icterohaemorrhagiae. 2. the nutrient value of serum is considerably reduced by heating to 60 degrees c. for 30 minutes and is destroyed by boiling (100 degrees c). filtration through a berkefeld filter does not diminish the nutrient value of the serum. 3. the cultural value of different animal sera varies considerably. it is entirely absent from the sera of the rat and the pig. the sera of the rabbit ...191819868228
the survival of leptospira (spirochaeta) icterohaemorrhagiae in nature; observations concerning microchemical reactions and intermediary hosts.1. leptospira icterohaemorrhagiae is unable to grow in the urine, either with or without the addition of suitable culture ingredients, the acidity of the urine being detrimental to the growth. it survives less than 24 hours, unless the urine is neutralized or slightly alkalized, when the period of survival is somewhat longer. if suitable nutrient ingredients are added to the neutralized or slightly alkalized urine, the organism is able to grow for about 10 days, after which multiplication ceases ...191819868229
spirochaeta hebdomadis, the causative agent of seven day fever (nanukayami) : first paper.a new species of spirochete which we have called spirochaeta hebdomadis has been described as the specific etiological agent of seven day fever, a disease prevailing in the autumn in fukuoka and other parts of japan. this spirochete is distinguishable from spirochaeta icterohaemorrhagiae to which it presents certain similarities. young guinea pigs are susceptible to inoculation with the blood of patients and to pure cultures of the spirochete, and those developing infection exhibit definite symp ...191819868269
spirochaeta hebdomadis, the causative agent of seven day fever (nanukayami) : second paper.1. spirochata hebdomadis is always present in seven day fever and can be confirmed by animal experiments with guinea pigs of light weight. 2. the causative agent of this disease can also be found in film preparations of the blood of patients, though it is not present in large numbers. 3. spirochaeta hebdomadis is discharged in the urine of patients having seven day fever. the number of spirochetes in the urine is great during convalescence. 4. seven day fever is a disease found not only in the p ...191919868314
the cultivation and biological characteristics of spirochaeta obermeieri (recurrentis).a study of the growth requirements of spirochoeta obermeieri resulted in the perfection of a method which enabled us (1) to cultivate the organisms consistently from the blood of infected mice and rats, (2) to maintain the viability of cultures for periods of at least 3 to 7 weeks, and (3) to carry them on in successive subcultures by transplanting at intervals of 2 to 4 weeks. this method is essentially the same as the noguchi technique for the cultivation of the leptospira group, but emphasize ...192219868607
spirochaeta eurygyrata : a note on its life history and cultivation.1. pure lines of spirochoeta eurygyrata were isolated and cultured. 2. they lived longest in a medium which was made up of sodium chloride and pig serum water. 3. they stained readily with iron-hematoxylin, giemsa's stain, cross' stain, and carbolfuchsin. 4. they did not stain with the vital dyes used. 5. they divide by transverse division. 6. transverse bars, which are seen in stained spirochetes and in dead ones with dark-field illumination, are considered coagulated protoplasm, due to death. ...192219868697
experiments on the production of wassermann reagins by means of trypanosomes.since it is known that positive wassermann reactions prevail in trypanosomiasis of rabbits, similar to those in syphilis, trypanosomes were used for an inquiry into the cause of this reaction. injections with dead trypanosomes into rabbits proved that these microbes are highly active antigens and suffice in themselves to produce strongly positive wassermann sera, in analogy to the findings reported by f. klopstock with spirochaeta pallida. although a number of questions require further study, ye ...192719869266
bosr (bb0647) governs virulence expression in borrelia burgdorferi.summary borrelia burgdorferi (bb), the lyme disease spirochaete, encodes a potential ferric uptake regulator (fur) homologue, bosr (bb0647). thus far, a role for bosr in bb metabolism, gene regulation or pathogenesis has not been determined, largely due to the heretofore inability to inactivate bosr in low-passage, infectious bb isolates. herein, we report the generation of the first bosr-deficient mutant in a virulent strain of bb. whereas the bosr mutant persisted normally in ticks, the mutant ...200919889086
borrelia burgdorferi, a great chameleon: know it to recognize it!borrelia burgdorferi is a spirochaete that can penetrate the blood-brain barrier in early infection and can cause endothelial damage other than central nervous system lesions. we describe a clinical case of neuroborreliosis that occurred in the absence of classical erythema migrans or arthralgia. magnetic resonance imaging findings compatible with simil-vasculitis and demyelinating lesions associated with the presence of anti-b. burgdorferi antibodies in the plasma or cerebrospinal liquid is an ...201019894021
brachyspira intermedia strain diversity and relationships to the other indole-positive brachyspira species.the aims of this study were to use multilocus sequence typing (mlst) to (i) investigate the population structure, diversity and molecular epidemiology of the weakly haemolytic anaerobic intestinal spirochaete brachyspira intermedia, and (ii) determine the relationship of the species to the other two indole-positive but strongly haemolytic brachyspira species--b. hyodysenteriae and "b. suanatina". seventy-seven b. intermedia isolates from pigs and chickens were analysed, with the nucleotide seque ...201019944544
evaluation of recombinant brachyspira pilosicoli oligopeptide-binding proteins as vaccine candidates in a mouse model of intestinal spirochaetosis.the anaerobic intestinal spirochaete brachyspira pilosicoli colonizes the large intestine of humans, and various species of animals and birds, in which it may induce a mild colitis and diarrhoea. the aim of the current study was to evaluate the use of putative oligopeptide-binding proteins of b. pilosicoli as vaccine components. a partial genome sequence of b. pilosicoli porcine strain 95/1000 was subjected to bioinformatics analysis, and six genes predicted to encode oligopeptide-binding protei ...201019959628
the distribution of treponema pallidum, schaudinn (spirochaeta pallida), in the tissues in congenital syphilis. 190619971740
a case of intra-uterine death of the foetus occurring in six consecutive pregnancies, with observations upon the importance of the examination of the foetal tissues for the presence of the spirochaeta pallida. 190819973170
specimen of spirochaeta pallida prepared with indian ink, with demonstration of method. 191019974263
the comparative neuropathology of trypanosome and spirochaete infections, with a résumé of our knowledge of human trypanosomiasis. 191119975395
a new spirochaeta found in human blood. 191319977210
the pathogenesis of rheumatic fever in its climatological relationship to a possible insect carrier.a short while ago a special sub-committee of the british medical association [1] sat to inquire into the problem of rheumatic heart disease in children, and suggested, among other conclusions, that the material for any accurate world map of the incidence of rheumatism was probably not available. my objects in presenting this paper are:-(1) to provide data for this map.(2) to show that the geographical distribution of rheumatic fever coincides with that of the common rat flea, ceratophyllus fasci ...192819986438
treponema denticola biofilm-induced expression of a bacteriophage, toxin-antitoxin systems and transposases.treponema denticola is an oral spirochaete that has been strongly associated with chronic periodontitis. the bacterium exists as part of a dense biofilm (subgingival dental plaque) accreted to the tooth. to determine t. denticola gene products important for persistence as a biofilm we developed a continuous-culture biofilm model and conducted a genome-wide transcriptomic analysis of biofilm and planktonic cells. a total of 126 genes were differentially expressed with a fold change of 1.5 or grea ...201020007650
a comparative analysis of molecular markers for the detection and identification of borrelia spirochaetes in ixodes ricinus.borrelia burgdorferi sensu lato, carried by ixodes ticks, is one of the most significant human pathogens, causing lyme disease. as there is no standardized pcr method for detection and identification of spirochaete dna, we carried out a comparative analysis using a set of complementary primers for three regions in the genomic dna of these bacteria (genes fla and rrs and the non-coding rrs-rrla region). dna extracted from 579 ixodes ricinus ticks was subjected to nested pcr. dna of the examined s ...201020007765
what is the percentage of pathogenic borreliae in spirochaetal findings of mosquito larvae?in this study, larvae (1,179 ex.) of mosquito genera culex were examined for the presence of spirochaetes by dark field microscopy (dfm) at the locality of blansko (czech republic) in of 2004-2008. dfm spirochaete positive samples (25.4 %) were investigated by nested pcr; only 4 samples were positive for the presence of borrelia burgdorferi sensu lato, which is 0.3 % of the total examined samples. we can conclude that only a low percentage of pathogenic borreliae are presented in mosquito larvae ...200920047261
a bacterial elongation factor g homologue exclusively functions in ribosome recycling in the spirochaete borrelia burgdorferi.translation elongation factor g (ef-g) in bacteria plays two distinct roles in different phases of the translation system. ef-g catalyses the translocation of trnas on the ribosome in the elongation step, as well as the dissociation of the post-termination state ribosome into two subunits in the recycling step. in contrast to this conventional view, it has very recently been demonstrated that the dual functions of bacterial ef-g are distributed over two different ef-g paralogues in human mitocho ...201020132446
spirochaeta perfilievii sp. nov., an oxygen-tolerant, sulfide-oxidizing, sulfur- and thiosulfate-reducing spirochaete isolated from a saline spring.a novel strain of fermenting, aerotolerant, chemo-organoheterotrophic spirochaete designated p(t) was isolated from a sulfur 'thiodendron' mat in a saline spring at the staraya russa resort (novgorod region, russia). cells of strain p(t) exhibited a helical shape. the spirochaete required sulfide in the growth medium and was able to oxidize it non-enzymically to elemental sulfur via the interaction of h(2)o(2) with sulfide and deposit it in the periplasmic space. growth occurred at 4-32 °c (opti ...201120173011
two novel salp15-like immunosuppressant genes from salivary glands of ixodes persulcatus schulze tick.salp15, a 15-kda tick salivary gland protein, is known for several suppressive activities against host immunity and critical functions for the transmission of lyme borrelia in ixodes scapularis and ixodes ricinus, the major vectors found in north america and western europe. salp15 inhibits the activation of cluster of differentiation (cd)4(+)t-cells through the repression of t-cell receptor (tcr)-triggered calcium fluxes and interleukin (il)-2 production. furthermore, salp15 adheres to the spiro ...201020201978
henry, the spirochaete, and the ladies. 194720243250
a new quick method for staining treponema pallidum. 194720244557
polymorphism in treponema recurrentis and spirochaeta vincenti. 194720249283
the minimal infectious inoculum of s. pallida in rabbits, and its rate of multiplication in vivo. 194720249674
[not available]. 194720253294
[not available]. 194720253525
[not available]. 194720253536
bacteriologic investigations of the oral spirochetal flora in ulcerative stomatitis (vincent's infection). 194720260856
[not available]. 194720268209
[not available]. 194720270416
[not available]. 194720270417
[not available]. 194720270430
[not available]. 194720270431
[purification of leptospira strains in vivo]. 194620277164
[liberation of leptospira strains from spontaneous agglutination]. 194620277165
[viability of leptospira on food materials]. 194620277166
acquired resistance of treponema pallidum to penicillin. 194620277710
agglutination of leptospirae. 194720278699
prolonged storage of human pathogenic protozoa with conservation of virulence; observations on the storage of helminths and leptospiras. 194720279331
[on isolation of cultures of spirochaeta pallida from syphilitic patients]. 194620279621
[on the possibility of the transmission by lice of the spirochetes of tick recurrent fever spirochaeta uzbekistanica (sp. sogdianum)]. 194520280628
the problem of identification of oral spirochetes and description of a precipitin test for their serological differentiation. 194620280884
silver impregnation of spirochetes in tissue sections; description of a new technic. 194620282141
the relative importance of the renal and hepatic lesions in experimental leptospirosis icterohaemorrhagica. 194620283070
preservation of borrelia vincenti and cultured strains of treponema pallidum by the lyophil process. 194720285099
a note on two blood parasites of cattle (spirochaeta theileri and bartonella bovis) recorded for the first time in australia. 194620290808
a new blood spirochaete in the grivet monkey; ceropithecus aethiops. 194720291370
agglutination studies of the smaller oral treponemes, borrelia vincenti and cultured strains of treponema pallidum. 194720292512
[not available]. 194620293718
[not available]. 194720296900
isolation of an unidentified spirochete from hen's eggs after inoculation with liver tissue from hens. 194720341597
loss of virulence of treponema pallidum during processing of dried blood serum. 194720344588
[coexisting of borreliosis, depression and psoriasis--case report].lyme disease is a multisystem infectious disease with a wide variety of symptoms involving the skin as well as the nervous system. lyme disease is caused by spirochaete borrelia burgdorferi transmitted by ixodes ticks in endemic regions. a case of 45 year old woman suffering from borreliosis, psoriasis and depression is presented in the paper. in the study a standardized screening list was applied to evaluate the psychiatric health state--classification of psychic disorders (dsm-iv) and hamilton ...201020369726
two regulatory elements required for enhancing ospa expression in borrelia burgdorferi grown in vitro but repressing its expression during mammalian infection.during cycling between the tick vector and a mammal, the lyme disease spirochaete borrelia burgdorferi must coordinate expression of outer-surface proteins (osps) a and b to quickly respond to environmental changes. the pathogen abundantly produces ospa/b in the tick, but represses their expression during mammalian infection. this paper reports a regulatory structure, consisting of two sequences flanking the ospab promoter, that is required for enhancing ospa expression in b. burgdorferi grown i ...201020395273
microbial dynamics in upflow anaerobic sludge blanket (uasb) bioreactor granules in response to short-term changes in substrate feed.the upflow anaerobic sludge blanket (uasb) reactor is a microcosm for the methanogenic degradation of organic matter in anaerobic environments, and depends on the auto-formation of dense 3d biofilms of 1-3 mm in diameter, referred to as granular sludge (biogranules). past research has shown that uasb and other methanogenic reactors are extremely stable functionally, but the underlying basis of the functional stability is not well understood. in this study, microbial dynamics in the communities r ...201020430810
spirochaetosis of mice due to spirochaeta muris n.sp. in the blood. 190620474291
the cultivation of spirochaeta icterohaemorrhagiae and the production of a therapeutic anti-spirochaetal serum. 191920474680
filtration experiments with spirochaeta schaudinnii. 193420475245
the role of the spirochaete in the wassermann reaction. 193920475495
ticks and lyme borreliosis in an alpine area in northeast italy.a 2-year study was conducted in a mountainous area of northeast italy to evaluate the occurrence and distribution of ticks, as well as to assess the prevalence of the spirochaete borrelia burgdorferi sensu lato. all ticks collected were ixodes ricinus l. (parasitiformes: ixodidae). in general, most nymphs and adult ticks were collected from april to july. tick density was highly variable among sites; however, two areas with different infestation levels were recognized. prevalences of b. burgdorf ...201020534008
crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick ornithodoros moubata.the saliva of blood-feeding parasites is a rich source of peptidase inhibitors that help to overcome the host's defence during host-parasite interactions. using proteomic analysis, the cystatin omc2 was demonstrated in the saliva of the soft tick ornithodoros moubata, an important disease vector transmitting african swine fever virus and the spirochaete borrelia duttoni. a structural, biochemical and biological characterization of this peptidase inhibitor was undertaken in the present study. rec ...201020545626
leptospira: a spirochaete with a hybrid outer membrane.summary leptospira is a genus of spirochaetes that includes organisms with a variety of lifestyles ranging from aquatic saprophytes to invasive pathogens. adaptation to a wide variety of environmental conditions has required leptospires to acquire a large genome and a complex outer membrane with features that are unique among bacteria. the most abundant surface-exposed outer membrane proteins are lipoproteins that are integrated into the lipid bilayer by amino-terminal fatty acids. in contrast t ...201020598085
seroprevalence of borrelia igg antibodies among young swedish children in relation to reported tick bites, symptoms and previous treatment for lyme borreliosis: a population-based survey.lyme borreliosis (lb) is the most common tickborne infection in sweden and the seroprevalence of borrelia immunoglobulin g (igg) antibodies varies between 2% and 26%. the seroprevalence in young swedish children is unknown and the relation to clinical data has not been previously studied.201020702388
host migration impacts on the phylogeography of lyme borreliosis spirochaete species in europe.the geographic patterns of transmission opportunities of vector-borne zoonoses are determined by a complex interplay between the migration patterns of the host and the vector. here we examine the impact of host migration on the spread of a tick-borne zoonotic disease, using lyme borreliosis (lb) spirochaetal species in europe. we demonstrate that the migration of the lb species is dependent on and limited by the migration of their respective hosts. we note that populations of borrelia spp. assoc ...201120722696
on the spirochaeta pallida and its variations. 190620762660
spirochaeta pallida: methods of examination and detection, especially by means of the dark ground illumination. 190920764459
observations on spirochaeta eurygyrata, as found in human faeces. 191620768165
a case of rat-bite fever in england: recovery of the spirochaete from the blood. 192420771458
demonstration of the variations of the spirochæta pallida, etc. (epidiascope and microscope). 190720897090
a case of intra-uterine death of the fœtus occurring in six consecutive pregnancies, with observations upon the importance of the examination of the fœtal tissues for the presence of the spirochæta pallida. 190820897567
specimen of spirochæta pallida prepared with indian ink, with demonstration of method. 191020898660
the comparative neuropathology of trypanosome and spirochæte infections, with a résumé of our knowledge of human trypanosomiasis. 191120899792
a new spirochæta found in human blood. 191320901607
genome sequence of the polysaccharide-degrading, thermophilic anaerobe spirochaeta thermophila dsm 6192.spirochaeta thermophila is a thermophilic, free-living anaerobe that is able to degrade various α- and β-linked sugar polymers, including cellulose. we report here the complete genome sequence of s. thermophila dsm 6192, which is the first genome sequence of a thermophilic, free-living member of the spirochaetes phylum. the genome data reveal a high density of genes encoding enzymes from more than 30 glycoside hydrolase families, a noncellulosomal enzyme system for (hemi)cellulose degradation, a ...201020935097
therapeutic action of different penicillins on spirochaeta recurrentis infections in mice. 194620984765
the structure of spirochaeta novyi as revealed by the electron microscope. 194620987023
isolation of virulent treponema pallidum from human aorta thirty-two hours after death from cardiovascular syphilis. 194620996102
the effect of low temperature on the spirochetes of relapsing fever. 194521005566
the effect of low temperature on the spirochetes of relapsing fever; the structure and motility of spirochaeta novyi. 194521005567
the structure of spirochaeta novyi as revealed by the electron microscope. 194521011725
the problem of reinoculation of human beings with spirochaeta pallida; a review of the literature. 194621018654
characterization of a novel family of fibronectin-binding proteins with m23 peptidase domains from treponema denticola.interactions with fibronectin are important in the virulence strategies of a range of disease-related bacteria. the periodontitis-associated oral spirochaete treponema denticola expresses at least two fibronectin-binding proteins, designated msp (major surface protein) and oppa (oligopeptide-binding protein homologue). to identify other t. denticola outer membrane fibronectin-binding proteins, the amino acid sequence of the treponema pallidum fibronectin-binding protein tp0155 was used to survey ...201021040511
exposure to norepinephrine enhances brachyspira pilosicoli growth, attraction to mucin and attachment to caco-2 cells.brachyspira pilosicoli is an anaerobic intestinal spirochaete that colonizes the large intestine of a variety of species of birds and mammals, including human beings. colonization may result in a mild colitis and diarrhoea in a condition known as 'intestinal spirochaetosis'. the catecholamine norepinephrine (ne), which is known to influence the behaviour of many bacterial species, may be present in the colon. the purpose of the current study was to determine whether exposure of b. pilosicoli to ...201021051488
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