Publications

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metabolic and biochemical aspects of heat acclimation in the deer mouse. peromyscus maniculatus sonoriensis. 19763322
preferences by deer mice for solutions of sugars, salts, and acids in richter-type drinking tests.deer mice (peromyscus maniculatus) were tested for taste preferences in 48-hour, richter-type drinking tests (sapid solution versus distilled water). the ss, which were seven male and seven female wild adults, were individually housed within an environmental chamber. test solutions were concentrations of five sugars and three salts (.005 m to 1.0 m) and of two acids (4.0 ph to 1.5 ph). the molar range was too limited to identify the most preferred concentration of glucose, but peak preferences f ...197826730
the interaction of shivering and non-shivering thermogenesis in deer mice (peromyscus maniculatus). 197937038
rodent models of the human isoniazid-acetylator polymorphism.inbred strains and subpopulations of rats, laboratory mice, and deer mice were examined for individual variation in the ability to metabolize several arylamines (p-aminobenzoic acid, sulfamethazine, aniline, alpha-naphthylamine, and aminofluorene) by n-acetylation. individual differences within species were found to be dependent upon the tissue source of n-acetyltransferase activity and the acetyl acceptor employed. long-evans rats possessed about 2-fold more p-aminobenzoic acid n-acetyltransfer ...197940765
hereditary cataracts in deer mice (peromyscus maniculatus).a new type of hereditary cataract was predicted in the deer mouse (peromyscus maniculatus) by the presence of syndactyly of the hind feet. early morphologic changes were found in the equatorial cells that differentiated into new lens fibers. later swelling at the anterior and posterior poles of these cells produced lens opacities. anterior and posterior subcapsular cataracts progressed to a hypermature shrunken lens.1975169695
physiological consequences of experimentally altering the population structure of peromyscus maniculatus in the field. 1975237700
a soluble immunosuppressor substance in spleen in deer mice infected with trypanosoma brucei.a soluble substance that blocks b-cell response was extracted from spleen of deer mice (peromyscus maniculatus) chronically infected with trypanosoma brucei. immunosuppressor activity of this substance was demonstrated by plaque-forming cell assays of spleen cells from swiss/webster mice inoculated with sheep red blood cells and simultaneously given the suppressor substance, and of spleen cell cultures treated with sheep red blood cells and suppressor substance. studies by light and electron mic ...1979316660
brachylaime microti: a mechanistic simulation model of the parasite, its intermediate snail host, oreohelix strigosa, and its definitive rodent hosts, peromyscus maniculatus and microtus montanus. 1977320029
postimplantation pregnancy disruption in microtus ochrogaster, m. pennsulvanicus and peromyscus maniculatus. 2004321775
immunosuppression in deer mice with experimentally induced trypanosomiasis.light and electron microscopic examinations of deer mice (peromyscus maniculatus) chronically infected with trypanosoma equiperdum revealed hyperplasia of germinal center lymphocytes (germanocytes) in the lymph follicles of spleen and lymph nodes and infiltration of the splenic red pulp cords and nodal medullary cords with plasma cells. proliferation and infiltration of plasma cells caused disruption of the b- and t-lymphocyte areas in these organs. stimulation of splenic lymphocytes in vitro by ...1977327872
experimental meningoencephalitis in trypanosoma brucei infection of deer mice (peromyscus maniculatus). a light, immunofluorescent, and electron microscopic study. 1977331839
rodent housing units for field studies.rodent housing and nesting units were constructed from acrylic and provided with concrete tops. these hexagonal units, placed in a wooded field, were inhabited by deer mice (peromyscus maniculatus). the use of the field housing units provided an effective method for observing free-ranging wild rodents.1979459426
cataract--webbed peromyscus. i. genetics of cataract in p. maniculatus.cataract--webbed (cw) in the deer mouse (peromyscus maniculatus) is a recessive mutant that is manifested by syndactyly (involving soft tissues) and eye defects including cataract. within cw/cw mice, the age at which cataract first appears is genetically controlled. evidence for the activity of genetic modifiers is the early appearance of cataracts in the offspring of parents that developed cataracts at early ages.1979469220
reproductive failure and maternal-fetal relationship in a peromyscus species cross.mating, fertilization, implantation, prenatal mortality, fetal and placental size, and placental ultrastructure were studied in intraspecific and interspecific crosses involving peromyscus maniculatus and p. polionotus. failure to mate was a major factor in interspecific crosses and was much more pronounced in crosses between p. polionotus females and p. maniculatus males than in the reciprocal cross. failure of implantation following mating, however, was more pronounced in crosses between p. ma ...1979490135
a study of the circadian rhythm and pre- and postpuberty concentrations of serum prolactin in male prairie deer mice (peromyscus maniculatus bairdii). 1979499748
space utilization of peromyscus: social and spatial factors.space utilization of peromyscus maniculatus bairdi and p. leucopus noveboracensis was studied in laboratory enclosures. after 1 week, individuals were given access to twice as much space for an additional week. the new rea was either vacant or was occupied by a similarly experienced conspecific of the same or opposite sex. patterns of space utilization and reaction to the doubling of space were species specific. each species displayed specific patterns of social behaviour and only p. maniculatus ...1977560813
effects of bot fly (cuterebra) parasitism on activity patterns of peromyscus maniculatus in the laboratory.peromyscus maniculatus subjected to bot fly (cuterebra) parasitism in the laboratory showed significant changes in amount and temporal distribution of several activity patterns. strenuous activities, such as running in an exercise wheel or stereotypic somersaulting, declined while less strenuous activities associated with maintenance behaviors increased. diurnal response to handling and disturbance declined significantly in infected mice. the temporal distribution of nocturnal activity was alter ...1978564978
in vitro fertilization of two species of deer mouse eggs by homologous or heterologous sperm and penetration of laboratory mouse eggs by deer mouse sperm.newly ovulated eggs from immature deer mice (peromyscus maniculatus and p. polionotus) and mature laboratory mice (mus musculus) treated with pmsg and hcg were inseminated in vitro with spermatozoa recovered from the cauda epididymidis of mature males. the time required for capacitation of deer mouse sperm in culture was estimated to be about two to five hours based on the dispersal of sperm agglutination and increase of sperm motility. the rate of sperm penetration through the zona pellucida of ...1979572865
the effects of indomethacin on plasma lh levels in female and male deermice (peromyscus maniculatus).the purpose of this investigation was to determine (1) the approximate time of the preovulatory lh rise in cyclic deermice, (2) the effect of indomethacin administration on plasma lh levels during the expected preovulatory lh rise, and (3) the effect of indomethacin administration on plasma lh levels in castrated male deermice. the data indicate that the preovulatory lh rise occurred at about 2200 h on proestrus and that indomethacin pretreatment significantly reduced plasma lh levels during tha ...1979575227
genetic variation of amylases in deer mice.the inheritance of salivary amylase variants in the deer mouse, peromyscus maniculatus, is controlled by codominant alleles, amy-1a, amy-1b, and amy-1c, at a single autosomal locus. pancreatic amylases were invariant and unaffected by salivary amylase genotypes. salivary amylase zymograms of five myomorphic rodents are compared and evolutionary implications are discussed.1977599282
sodium pentobarbital induced alterations in regional distribution of blood in peromyscus maniculatus (deer mouse) and eptesicus fuscus (big brown bat). 1977606346
the natural history and development of cuterebra approximate (diptera: cuterebridae) in its natural host, peromyscus maniculatus (rodentia: cricetidae), in western montana. 1977606811
vulnerability of bot fly (cuterebra) infected peromyscus maniculatus to shorttail weasel predation in the laboratory.in the laboratory, peromyscus bearing a single cuterebra larva are no more vulnerable to weasel predation than are uninfected control mice, and may be taken less often under certain conditions. mice bearing two or more larvae appear to be more vulnerable than either controls or singly infected mice. their increased vulnerability probably results from their failure to use arboreal pathways. decreased activity may be responsible for the relative advantage of singly infected mice. previous reports ...1978633515
ultrastructural and immunological aspects of the phagocytosis of trypanosoma brucei by mouse peritoneal macrophages.trypanosome-activated mouse peritoneal macrophages phagocytized and digested trypanosoma brucei in vitro and in vivo, but in the absence of specific antiserum and complement the degree of phagocytosis was minimal. ultrastructurally, the parasites attached to the macrophage by their flagella, and ingestion proceeded flagellum first. once ingested, t. brucei was degraded, presumably due to fusion of the parasite-containing phagosome with lysosomes. contrariwise, normal mouse peritoneal macrophages ...1978640740
genetics of hemoglobin in the deer mouse, peromyscus maniculatus. i. multiple alpha- and beta-globin structural loci.genetic data, together with molecular structure studies, have demonstrated that the complex hemoglobin phenotypes in four subspecies of p. maniculatus are generated by at least four, and probably five, globin structural loci. the hba and hbc loci apparently arose by duplication of an ancestral alpha-type locus, while hbb, hbd, and hbe apparently were derived from a beta-type locus. the hba and hbb structural loci are electrophoretically monomorphic, while hbc, hbd, and hbe are each polymorphic f ...1978669255
genetics of hemoglobin in the deer mouse, peromyscus maniculatus. ii. multiple alleles at regulatory loci.deer mice are polymorphic for electrophoretic hemoglobin phenotypes showing one, two, or three bands. within the multibanded phenotypes, there is considerable variation in the hemoglobin partitioning, defined as the fraction of total hemoglobin made up by the secondary and tertiary bands. in subspecies sonoriensis, for example, hemoglobin partitionings range from 0.03 to 0.38. the inheritance of partitioning values is under remarkably strict genetic control. the genetic variation is additive and ...1978669256
seasonally variable effects of conspecific odors upon capture of deer mice (peromyscus maniculatus gambelii). 1978678266
poison-based taste aversion learning in deer mice (peromyscus maniculatus bairdi).a series of experiments tested the ability of mice of the native genus peromyscus to form learned taste aversions. it was found that (a) the mice acquired a strong aversion after a single flavor/toxicosis pairing, (b) naive mice drinking a licl solution apparently began to experience toxic effects within 90 sec after the beginning of consumption, (c) the mice acquired a total aversion after a single flavor/delayed illness pairing when high doses of toxin were employed, and (d) the aversion produ ...1978690287
on the occurrence of microsporum persicolor in montreal, canada.a case of microsporum persicolor skin infection in a casual employee of a veterinary clinic in montreal, quebec, canada, is reported. a survey of 80 wild rodents in the montreal area resulted in the isolation of m. persicolor from two voles (clethrionomys gapperi) and one deer mouse (peromyscus maniculatus). one of the voles, heavily infested with parasites including ticks, had obvious lesions on the nose. this is the first report of m. persicolor in rodents in north america.1978714147
fractional factorial analysis of growth and weaning success in peromyscus maniculatus.fractional factorial designs were used to explore simultaneously the effects of eight variables on survival and growth of neonatal deer mice, peromyscus maniculatus. two of the variables had significant effects on weaning success. the magnitudes of their effects are illustrated.1978715451
the existence of a puberty accelerating pheromone in the urine of the male prairie deermouse (peromyscus maniculatus bairdii). 1978719090
genetic regulation of liver alcohol dehydrogenase in peromyscus.data from genetic crosses of peromyscus maniculatus and p. polionotus suggests that electrophoretic variants of liver alcohol dehydrogenase are coded by alleles at a single locus. these alleles, designated adhf, adhs, and adhn, determine, respectively, the fast, slow, and not detectable (null) adh electrophoretic phenotype. heterozygotes (adhf/adhs) exhibit three bands on zymograms, suggesting a dimeric subunit structure for the enzyme. however, adhf/adhn and adhs/adhn animals exhibit a single b ...1978736881
variation in the genetic structure of peromyscus populations. i. genetic heterozygosity--its relationship to adaptive divergence.the genetic structure of nine peromyscus maniculatus nebrascensis demes from southeastern wyoming was determined by analyzing allozymes encoded by 23 genetic loci with polyacrylamide gel electrophoresis. genetic variability is extremely high for two genetic parameters; the proportion of loci polymorphic per deme averaged 0.41. previous estimates of genetic heterozygosity for species within the genus peromyscus have a mean of 0.06. the results of the present study suggest that genetic heterozygos ...1978751646
breeding and reproduction of fifteen wild rodents maintained as laboratory colonies.data on reproduction and production were presented for laboratory colonies of microtus pennsylvanicus tananaensis, m oeconomus macfarlani, m o operarius, m mirurus, m abbreviatus, lemmus lemmus, l sibiricus trimucronatus, dicrostonyx stevensoni, clethrionomys rutilus, peromyscus maniculatus borealis, p m bairdii, baiomys taylori, calomys ducilla, c callosus, acomys cahirinus. litter size varied from 2.0 in a cahirinus to 5.5 in c callosus. infant (neonatal) and juvenile losses through the end of ...1976775192
meningoencephalitis in trypanosoma equiperdum infection of deer mice (peromyscus maniculatus). 1977838897
serum corticosterone concentrations in reproductively mature and inhibited deermice (peromyscus maniculatus bairdii).serum corticosterone concentrations were measured to see if there was any correlation between adrenal activity and reproductive inhibition. males and females from two growing and one stable (asymptotic) population had significantly smaller reproductive organs (seminal vesicles, testes, uteri, ovaries) than controls. the weights of the adrenal glands of population mice were smaller, often significantly so, than those of controls, but the mean serum corticosterone concentrations were higher than t ...1977850211
effects of experimental bot fly parasitism on gonad weights of peromyscus maniculatus. 1977925527
adiaspiromycosis in the franklin's ground squirrel, spermophilus franklini, and pika, ochotona princeps, from alberta, canada.pulmonary adiaspiromycosis due to emmonsia crescens was diagnosed in three of six franklin's ground squirrels (spermophilus franklini) captured in rochester, central alberts, canada in the summer of 1971, and in one of 240 pikas (ochotona princeps) collected in southwestern alberta in 1969. granulomas measuring 0.5 to 1 mm in diameter were found in both lungs. these granulomas contained adiaspores measuring 60 to 400 mum in diameter. the disease was not found in six franklin's ground squirrels c ...1976943581
genetic and developmental variation of hemoglobin in the deermouse, peromyscus maniculatus.a genetic investigation of electrophoretic hemoglobin variants of the deermouse, peromyscus maniculatus, shows three alleles, hblf, hblr, and hblo, at a duplicated site controlling the six adult phenotypes. the hblf allele has not been described previously. the hemoglobin locus is not closely linked to the albino locus. fetal hemoglobin is distinct from any of the adult components and has a slower electrophoretic mobility. the fetal phenotype changes to the adult type between the days 15 and 18 ...1976962849
genetic divergence of insular populations of deer mice.electrophoretic variants at 28 genetic loci were analyzed in subspecies of peromyscus maniculatus endemic to the channel islands of the california coast. the genetic variability within insular populations was calculated. these deer mice have relatively high levels of polymorphism for insular populations. the mean heterozygosity per individual varies in the populations, being much higher on one of the islands than the others. nei's measure of genetic distance between groups compared on the basis ...19761008806
comparison of yearly prevalences of echinococcus multilocularis leuckart 1863 in peromyscus maniculatus and microtus pennsylvanicus in north dakota. 19751104799
plasma progesterone concentrations in prairie deermice (peromyscus maniculatus bairdii) from experimental laboratory populations.body weights, ovary weights, plasma progesterone concentrations and ovarian histology were studied in females from asymptotic laboratory populations in which reproduction was inhibited and throughout the oestrous cycle of control nulliparous prairie deermice. body and ovary weights of population animals were significantly lighter and plasma progesterone concentrations were not significantly different from those of the control females. the control females exhibited cyclic changes in plasma proges ...19751123810
reproductive performance of a laboratory colony of the deermouse, peromyscus maniculatus gambelii.during a 23-mo period approximately 600 litters and 2,500 offspring were produced in a laboratory colony established with wild-trapped deermice (peromyscus maniculatus gambelii). the incidence of pregnancy and size of litters increased with domestication. average litter size was 4.3 for all litters and 4.1 and 4.7 for litters born to wild-trapped and first generation females, respectively. litter size increased up to the seventh sequential pregnancy for both wild-caught and first-generation fema ...19751152419
the effects of differential prenatal and postnatal social enviroments on sexual maturation of young prairie deermice (peromyscus maniculatus bairdii).we compared the influence of different social enviroments on sexual maturation of young prairie deermice. between 12 and 48 hr after parturition, one-half of a litter from a population was exchanged with one-half of a litter from a bisexual pair. in each situation the remaining half-litter served as controls for the exchange procedure. the testes and vesicular weights of population-reared males were significantly larger than those of males reared by bisexual pairs, irrespective of prenatal envir ...19751163849
native resistance of peromyscus maniculatus to nematospiroides dubius infection. 19761253923
dermacarus jonesi sp. n. (acari: labidophorinae: glycyphagidae) from peromyscus maniculatus from western north america.a new species of labidophorine hypopus, dermacarus jonesi, is described from peromyscus maniculatus from washington, usa, and british columbia, canada. a single individual was also found on sorex sp. from california.19761255357
the effects of feeding triiodothyronine on reproductively inhibited prairie deermice (peromyscus maniculatus bairdii) from laboratory populations.1. two reproductively inhibited populations were given 250 ng triiodothyronine (t3) per gram of food for 35 days to elevate the reduced serum thyroid hormone concentration previously demonstrated in reproductively inhibited animals and to determine if the treatment would promote recovery. 2. per capita food intake was significantly increased but per cent body fat tended to decrease and body weight did not significantly increase during t3 treatment. 3. mean testis and seminal vesicle weights of t ...19921354582
sex differences in the effects of tyr-mif-1 on morphine- and stress-induced analgesia.there is evidence suggesting that the endogenous tetrapeptide, tyr-mif-1 (tyr-prol-leu-gly-amide), has antagonistic or modulatory effects on opioid-mediated analgesia. there is also substantial evidence for sex differences in opioid effects, whereby male rodents display greater levels of opioid-mediated analgesia than females. in the present study, determinations were made of the effects of tyr-mif-1 on morphine- and restraint stress-induced opioid analgesia in adult male and female deer mice, p ...20131362981
cotton rats and other small mammals as hosts for immature dermacentor variabilis (acari: ixodidae) in central oklahoma.eight species of small mammals were evaluated as potential hosts for american dog ticks, dermacentor variabilis (say), in an upland, tallgrass prairie study site in central oklahoma. only hispid cotton rats, sigmodon hispidus, and deer mice, peromyscus maniculatus, were found to be important hosts for immature d. variabilis. although d. varibilis larvae and nymphs frequently infested both cotton rats and deer mice, cotton rats were the most important host species for both immature stages in the ...19921404263
effect of reproductive function on cold tolerance in deer mice.thermoregulatory responses were evaluated in male deer mice (peromyscus maniculatus nebrascensis) after exposure to short photoperiod and either warm or cold ambient temperature (t(a)). deer mice were chosen for this study because males exhibit differential reproductive responses to short day length (sd); this difference has a genetic basis, and both phenotypes are found within natural breeding populations. deer mice undergoing sd-induced gonadal regression significantly improved their cold limi ...19921415794
photoperiod influences the critical caloric intake necessary to maintain reproduction among male deer mice (peromyscus maniculatus).the concept of critical day length is well established among rodents; reproductive function is maintained when day lengths are greater than some specific threshold. in addition to day length cues, seasonal breeding in deer mice can also be regulated by food availability. the caloric threshold necessary to support reproduction remains unspecified for seasonally breeding rodents. the present study examined the interaction between photoperiod and food availability on reproductive function in adult ...19921536898
seasonal prevalence of taenia taeniaeformis: relationship to age, sex, reproduction and abundance of an intermediate host (peromyscus maniculatus).livers from 4,501 deer mice (peromyscus maniculatus) collected from a weedy habitat in northeastern california during 48 consecutive monthly samplings were examined microscopically for taenia taeniaeformis larva. although there were pronounced seasonal fluctuations in host density, there were no significant annual or season-related differences in cestode intensities in adult deer mice. there were no significant differences in prevalences associated with sex of the host, nor were there significan ...19921548801
tissue-specific metabolism during normothermy and daily torpor in deer mice (peromyscus maniculatus).previous work with deer mice (peromyscus maniculatus) has demonstrated that a significant acidosis occurs during daily torpor. in addition, carbohydrate levels are significantly lower, whereas fatty acid and ketone levels are significantly higher during torpor. the present study examined the effects of these in vivo acid-base and metabolite adjustments on in vitro 14c-glucose metabolism in tissues taken from normothermic and torpid deer mice. glucose oxidation in liver and vastus lateralis taken ...19921569409
uptake of environmental contaminants by small mammals in pickleweed habitats at san francisco bay, california.small mammals were live-trapped in pickleweed (salicornia virginica) habitats near san francisco bay, california in order to measure the uptake of several contaminants and to evaluate the potential effects of these contaminants on the endangered salt marsh harvest mouse (reithrodontomys raviventris). tissues of house mice (mus musculus), deer mice (peromyscus maniculatus), and california voles (microtus californicus) from nine sites were analyzed for chemical contaminants including mercury, sele ...19921586203
factors associated with the mass of venom expended by prairie rattlesnakes (crotalus v. viridis) feeding on mice.the purpose of this study was to assess through correlation analyses the various factors and consequences associated with the mass of venom injected by prairie rattlesnakes (crotalus v. viridis) into their natural prey, deer mice (peromyscus maniculatus). fifty-seven predator-prey interactions were studied via slow motion videotape review. the mass of venom expended by snakes during biting was quantified by enzyme-linked immunosorbent assay (elisa) of whole-animal homogenates. the quantity of ve ...19921626326
the comparative distribution of forebrain receptors for neurohypophyseal peptides in monogamous and polygamous mice.several recent studies have suggested that the neurohypophyseal peptide oxytocin may have a role within the brain to mediate various forms of affiliative behavior. as the regulation of oxytocin function may be largely determined by the number and distribution of its membrane bound receptor, we investigated oxytocin receptor distribution in two peromyscus species selected for differences in affiliative behavior. using in vitro receptor autoradiography with the selective oxytocin receptor ligand [ ...19911656322
oxidoreduction of butanol in deermice (peromyscus maniculatus) lacking hepatic cytosolic alcohol dehydrogenase.in view of conflicting information in the literature regarding enzyme systems responsible for alcohol oxidation in deermice previously reported to lack hepatic alcohol dehydrogenase (adh) activity, the reversibility of butanol oxidation was studied in vivo and in liver-perfusion systems. mixtures of [1,1-2h2]ethanol and butanol were given intraperitoneally to deermice lacking (adh-) or possessing (adh+) adh activity, followed by analysis of alcohols in blood by gc/ms. 2h exchange between the two ...19921740147
new host and locality records of coccidia (apicomplexa: eimeriidae) from rodents in the southwestern and western united states.one hundred forty-seven murid and heteromyid rodents were collected from various sites in the southwestern and western united states (arizona, colorado, new mexico, texas, and utah) and baja california norte, mexico, and their feces were examined for coccidial parasites. of these, 53 (36%) were infected with at least 1 coccidian; 45 of 53 (85%) of the infected rodents harbored only 1 species of coccidian. infected rodents included: 10 of 22 (45%) neotoma albigula, 3 of 11 (27%) neotoma floridana ...19911779282
differential reproductive response to short photoperiod in deer mice: role of melatonin.inhibitory photoperiod differentially effects reproduction in deer mice (peromyscus maniculatus nebrascensis). pituitary-testicular function is arrested in about one-third of short-day exposed males (reproductively responsive mice), while an equal number remain fertile (reproductively nonresponsive mice). both phenotypes are found in natural populations and their disparate reproductive responses have a genetic basis. to assess whether this difference is attributable to a prepineal/pineal or post ...19911779421
the effect of unsaturated and saturated dietary lipids on the pattern of daily torpor and the fatty acid composition of tissues and membranes of the deer mouse peromyscus maniculatus.dietary lipids strongly influence the pattern of torpor and the body lipid composition of mammalian hibernators. the object of the present study was to investigate whether these diet-induced physiological and biochemical changes also occur in species that show shallow, daily torpor. deer mice, peromyscus maniculatus, were fed with rodent chow (control diet) or rodent chow with either 10% sunflower seed oil (unsaturated diet) or 10% sheep fat (saturated diet). animals on the unsaturated diet show ...19911783690
splenomegaly and reticulocytosis caused by babesia microti infections in natural populations of the montane vole, microtus montanus.a survey for babesia microti in rodents was conducted at six sites within grand teton national park, wyoming. blood and spleen smears, hematocrits, and reticulocyte counts were made on all of the animals to evaluate parameters for the diagnosis of babesiosis. ticks were removed for identification. of 257 microtus montanus, 103 were infected with b. microti. in addition, five of 12 microtus pennsylvanicus and one of three arvicola richardsoni were parasitized by b. microti. peromyscus maniculatus ...19911818201
warble development by the rodent bot cuterebra fontinella (diptera: cuterebridae) in the deer mouse.warbles induced by the rodent bot fly larvae, cuterebra fontinella, developed over a period of 3.5-4 weeks in the deer mouse peromyscus maniculatus. warble location, structure and dynamics were examined. clustering of warbles occurred primarily within the inguinal region of the deer mouse with a significant number favoring the area between the anus and genital organ. no differences in warble production were found in hosts of either sex. on two occasions, a warble was encountered forming directly ...19911882496
ontogeny of striking, prey-handling and envenomation behavior of prairie rattlesnakes (crotalus v. viridis).the ontogeny of striking, prey-handling and envenomation behavior was studied in the prairie rattlesnake (crotalus v. viridis). snakes of three size classes (small, medium, large) were allowed to strike and envenomate deer mice (peromyscus maniculatus) of corresponding size. the mass of venom expended in a single strike, assayed by enzyme-linked immunosorbent assay (elisa) of whole-mouse homogenates, increased exponentially with length of the snake. small snakes embedded their fangs in prey for ...19911926185
morphological analysis of hair in the hr-2 mutant deer mouse (peromyscus maniculatus).skin from 36 hairless deer mice (peromyscus maniculatus) homozygous for the recessive hr-2 mutation were analyzed for structural defects in hair and hair loss. comparison of mutant to wild-type hairs demonstrated characteristic abnormalities in cellular organization, hair shape, length, and fragility. matings between mutants homozygous for the hr-2 gene and for a second mutation producing hairlessness in deer mice, hr-1, showed that these two genes were nonallelic. structural abnormalities in ha ...19911940285
lyme disease in california: interrelationship of ixodid ticks (acari), rodents, and borrelia burgdorferi.the association of immature ixodid ticks, several species of rodents, and the lyme disease spirochete, borrelia burgdorferi johnson, schmid, hyde, steigerwalt & brenner, was studied in two habitats in northern california in spring and summer 1985 and year-round in 1986. a total of 428 rodents were collected from ecotonal chaparral and a woodland-grass-rock outcrop; the former habitat yielded six species, the latter three species. the deer mouse, peromyscus maniculatus (wagner), and the piñon mou ...19911941942
survey for ixodes spp. and borrelia burgdorferi in southeastern wisconsin and northeastern illinois.forested areas adjacent to milwaukee, wis., and chicago, ill., were investigated for rodents and ticks infected with borrelia burgdorferi, the causative agent of lyme disease. white-footed mice (peromyscus leucopus or peromyscus maniculatus), meadow voles (microtus pennsylvanicus), and eastern chipmunks (tamias striatus) were captured; and specimens from these animals were cultured for b. burgdorferi to define whether the midwestern lyme disease area currently encompasses these large metropolita ...19912007650
sex differences in the inhibitory effects of the nmda antagonist, mk-801, on morphine and stress-induced analgesia.we examined the effects of intraperitoneal administrations of the noncompetitive nmda receptor antagonist, (+) mk-801, its inactive enantiomer, (-) mk-801, and the prototypic opiate antagonist, naloxone, on restraint- and morphine-induced analgesia in male and female deer mice, peromyscus maniculatus. both restraint (30 min) and morphine (1.0 mg/kg) induced significant analgesic responses with male mice displaying significantly greater levels of opioid-induced analgesia than female animals. thes ...19902162721
developmental changes in opiate-induced analgesia in deer mice: sex and population differences.we examined developmental changes in nociception and mu (morphine) and kappa (u-50,488) opiate-induced analgesia in male and female deer mice of two different populations; peromyscus maniculatus artemisiae from a mainland region and p. m. angustus from a small island. both populations displayed significant developmental changes in nociception and morphine (10 mg/kg) and u-50,488 (10 mg/kg)-induced analgesia. basal thermal response latencies (nociceptive responses) and the levels of mu and kappa ...19902163727
coat color genetics of peromyscus. i. ashiness, an age-dependent coat color mutation in the deer mouse.ashy deer mice (peromyscus maniculatus) were first discovered about 1960 in a wild population from oregon. although indistinguishable from the wild type at weaning, ashy deer mice become progressively grayer with subsequent molts. the trait is inherited as an autosomal recessive and the symbol ahy is assigned for the locus. the trait is distinctly manifest by 6 months of age, at which time homozygotes have white hairs on the muzzle and at the base of the tail. the amount of white gradually incre ...19902177072
hypothalamic monoamines and their metabolites in the deermouse, peromyscus maniculatus, during daily torpor.deermice, subjected to food rationing, an ambient temperature below thermal neutrality and short photoperiod, were sacrificed in euthermia or during daily torpor. hypothalamic monoamine and metabolite levels were quantified by hplc with electrochemical detection. significant elevations in the levels (pg/microgram protein) of dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid were noted in the torpid animals. the concentrations of norepinephrine and serotonin displayed no significant ...19902297395
intracellular ph during daily torpor in peromyscus maniculatus.intracellular and extracellular acid-base parameters during normothermy and daily torpor were examined in deer mice (peromyscus maniculatus). [14c]dimethyloxazolidinedione and [3h]inulin were used to assess intracellular ph in liver, heart, skeletal muscle, and brain. buffering capacities were determined using tissue homogenates. a significant increase in plasma pco2 and cco2 during daily torpor indicates a respiratory acidosis. all tissues experienced a reduction in the calculated dissociation ...19902335594
tests of preferences of young deer mice (peromyscus maniculatus bairdi) for siblings versus nonsiblings.three experiments were conducted to test the performance of young deer mice (peromyscus maniculatus bairdi) in associating preferentially with siblings versus nonsiblings. in experiment 1, neither males nor females preferred caged siblings versus nonsiblings. in experiment 2, with full contact permitted, nonsibling males were in contact as much as were sibling males. in experiment 3, with pairs of littermate pairs permitted full contact, there was no significant differential association. althoug ...19902364662
tests of preferences of adult deer mice (peromyscus maniculatus bairdi) for siblings versus nonsiblings.seven experiments were conducted to test the performance of adult deer mice (peromyscus maniculatus bairdi) in discriminating and preferring siblings versus nonsiblings. in two experiments there was no indication of preferences based on odor alone. further, there was no indication of kin discrimination in a seminatural enclosure. there was some indication that in a test apparatus, estrous females associate preferentially with male siblings rather than nonsiblings. the effect appears dependent on ...19902364663
in vivo formation of a free radical metabolite of ethanol.free radical metabolism of ethanol has been suggested as a factor in its hepatotoxicity. although evidence of lipid radical formation due to ethanol treatment in vivo has been reported, free radicals from ethanol itself have not been detected in living animals. however, by applying the epr spectroscopy technique of spin trapping to the study of ethanol-treated alcohol dehydrogenase-deficient deermice (peromyscus maniculatus), we have detected the alpha-(4-pyridyl-1-oxide)-n-t-butylnitrone (pobn) ...19902370854
comparative anatomy of the retino-hypothalamic tract in photoperiodic and non-photoperiodic rodents.this study examined whether the nearly symmetrical input from each eye to each suprachiasmatic nucleus previously reported in syrian hamsters (mesocricetus auratus) is a universal feature of retino-hypothalamic projections in photoperiodic rodents. intraocular injections of horseradish peroxidase (hrp) were used to trace the retino-hypothalamic tract in three species of photoperiodic rodents, turkish hamster (mesocricetus brandti), deer mouse (peromyscus maniculatus bairdi) and white-footed mous ...19862430681
population differences in benzodiazepine sensitive male scent-induced analgesia in the deer mouse, peromyscus maniculatus.we compared opioid and nonopioid involvement in the mediation of scent-induced analgesia in two populations of deer mice, peromyscus maniculatus; p. m. artemisiae from a mainland region and p. m. angustus from a small marine island. exposure to bedding taken from the soiled home cage of an isolated (dominant aggressive) male resident elicited a significant increase in the nociceptive responses of male deer mice from mixed sex pairs, with the island population of mice displaying significantly gre ...19892544899
muscle capillary tortuosity in high altitude mice depends on sarcomere length.at given capillary-to-fiber ratio and sarcomere length, capillary tortuosity determines capillary length and the geometry of blood-tissue exchange in muscles. it is therefore an important determinant of the potential efficiency of o2 supply to the muscle fibers. reports have indicated that capillary tortuosity increases with adaptation to hypoxia. unfortunately, sarcomere length was not taken into account. because capillary tortuosity increases substantially as the muscle shortens, it is importa ...19892749029
muscle fiber size and chronic exposure to hypoxia.sarcomere length is practically never considered when fiber size and dependent variables are compared between muscles or experimental conditions. because of the direct dependence of fiber cross-sectional area on muscle shortening, it is imperative to normalize measurements of fiber size, and related variables (e.g. capillary number/mm2 of fiber) to sarcomere length. we examined the relationship between fiber cross-sectional area and sarcomere length in muscles of animals chronically exposed to h ...19892782154
annual cyclicity of gall stone prevalence in deer mice (peromyscus maniculatus gambelii).the prevalence of gall stones (100% cholesterol) in a deer mouse (peromyscus maniculatus) population located in siskiyou county, california (usa) was studied on a monthly basis from february 1985 through january 1988. during each year we documented a pronounced annual cyclicity with peak prevalence (31 to 53%) during the winter and low prevalence (2 to 3%) during late summer. gall stone prevalence was not related to sex or age of the animal. the earliest onset of gall stone production and the ma ...19892810546
analysis of serotonin, dopamine and their metabolites in the caudate putamen, the suprachiasmatic nucleus and the median raphe nucleus of euthermic and torpid deermice, peromyscus maniculatus.deermice, subjected to food rationing and low ambient temperature, were sacrificed in normothermia or during daily torpor. levels of monoamines and their metabolites in the caudate putamen (cpn), the suprachiasmatic nuclear area (scn), and the median raphe nucleus (mrn) were quantified through the use of hplc with electrochemical detection. significant elevations in levels (pg/mg protein) of the serotonin (5-ht) metabolite, 5-hydroxyindole-3-acetic acid (5-hiaa) were noted in torpid individuals ...20082813470
male scent-induced analgesia in the deer mouse, peromyscus maniculatus: involvement of benzodiazepine systems.exposure to bedding taken from the soiled home cage of an isolated male resident elicited a significant increase in the nociceptive responses of male deer mice, peromyscus maniculatus artemisiae, from mixed sex pairs. the analgesia induced by exposure to the male scent was insensitive to the opiate antagonist, naloxone, and was blocked by either pre- or post-olfactory exposure injections of the benzodiazepine antagonist, ro 15-1788, or agonist, diazepam. this non-opioid analgesia was of brief du ...19882835786
cytochrome oxidase activity in brown fat varies with reproductive response and use of torpor in deer mice.reproductive responses and thermogenic properties of brown adipose tissue (bat) were evaluated in individuals from an outbred population of deer mice (peromyscus maniculatus nebrascensis) after 10 weeks exposure to short photoperiod (8:16 light:dark) and cold ambient temperature (2 degrees c). deer mice populations are composed of phenotypes that differ in their reproductive response to environmental cues. these phenotypes also differ in body temperature regulation as indicated by their use of d ...19882845453
serological and virological evidence of a hantaan virus-related enzootic in the united states.the first isolation of a hantaan-related virus from a feral rat in the united states was made from a rattus norvegicus caught in new orleans. the strain, designated tchoupitoulas virus, is antigenically related to, but distinct from, the prototype strain 76-118 of hantaan virus and is the first hantaan-like virus isolated from the pancreas of a naturally infected animal. serosurveys of wild rodents from urban and rural areas in the united states indicated that hantaan-related viruses infected ur ...19852861241
metabolic and thermoregulatory effects of photoperiod and melatonin on peromyscus maniculatus acclimatization.a photoperiod-related seasonal rhythm in active period (scotophase), metabolic rate and core temperature was documented for animals held at 21.0 +/- 0.1 degrees c ambient; animals that were habituated to long nights (10:14ld) had a greater metabolic reserve than those held in summer photoperiods (14:10ld). while relative weights of gonads and sex accessory tissues of mice show typical "winter" regression, interscapular brown adipose tissue mass was unaffected by photoperiod; moreover, ibat beta ...19852866895
bioenergetic benefits of huddling by deer mice (peromyscus maniculatus).both short photoperiod and communal social living conserve metabolic energy by deer mice held in thermal neutral ambient temperatures. initial socialization was energetically more costly than solitary living, but huddling behaviors reduced thermal conductance and mass specific metabolic rate by 30% within 5 days. while short photoperiod reduced metabolic energy expenditure by decreasing thermoregulatory demand, huddling mediated behavioral conservation was achieved with hyperthermic core tempera ...19862879682
serological survey of prospect hill virus infection in indigenous wild rodents in the usa.we found serological evidence of infection with prospect hill virus, a hantaan-like virus isolated from meadow voles (microtus pennsylvanicus), in microtine and cricetid rodents trapped in maryland, west virginia, minnesota and california, usa. fluorescent antibodies were detected in sera from m. pennsylvanicus (74/277), m. californicus (39/185), clethrionomys gapperi (5/51), peromyscus maniculatus (4/22) and p. truei (1/11). sera from seropositive p. maniculatus contained neutralizing antibodie ...19872895510
the relationship between food intake, body fat and reproductive inhibition in prairie deermice (peromyscus maniculatus bardii).1. reproductively-inhibited deermice selected from four laboratory populations consumed significantly less food than reproductively-proven pairs. 2. reproductively-inhibited animals predominantly, but not consistently, had reduced total body fat compared with reproductively capable deermice. 3. the per capita food consumption rate of two populations followed for 26 weeks since founding, decreased over time to about 65% of the daily intake of the proven animals used to found the populations. 4. a ...19882899486
serologic evidence of yersinia pestis infection in small mammals and bears from a temperate rainforest of north coastal california.from 1983 to 1985, 463 serum samples from 11 species of mammals in redwood national park (rnp) (california, usa) were evaluated for antibodies to yersinia pestis by the passive hemagglutination method. yersinia pestis antibodies occurred in serum samples from 25 (36%) of 69 black bears (ursus americanus), one (50%) of two raccoons (procyon lotor), five (3%) of 170 dusky-footed woodrats (neotoma fuscipes), and one (less than 1%) of 118 deer mice (peromyscus maniculatus). two hundred seventy-three ...19892915403
dehydrogenase-dependent ethanol metabolism in deer mice (peromyscus maniculatus) lacking cytosolic alcohol dehydrogenase. reversibility and isotope effects in vivo and in subcellular fractions.elimination of [2h]ethanol in vivo as studied by gas chromatography/mass spectrometry occurred at about half the rate in deer mice reported to lack alcohol dehydrogenase (adh-) compared with adh+ deer mice and exhibited kinetic isotope effects on vmax and km (d(v/k] of 2.2 +/- 0.1 and 3.2 +/- 0.8 in the two strains, respectively. to an equal extent in both strains, ethanol elimination was accompanied by an ethanol-acetaldehyde exchange with an intermolecular transfer of hydrogen atoms, indicatin ...19892925622
role of alcohol dehydrogenase in the swift increase in alcohol metabolism (siam). studies with deer mice deficient in alcohol dehydrogenase.previous studies have shown that rates of ethanol metabolism increase markedly 2-4 hr after the administration of ethanol in rats and in four inbred strains of mice. this phenomenon, called the swift increase in alcohol metabolism (siam), also exists in humans. to determine whether alcohol dehydrogenase (adh) is necessary for the siam response, we compared ethanol metabolism in two strains of the deer mouse, peromyscus maniculatus. one strain lacks alcohol dehydrogenase (adh-negative), whereas t ...19852932115
hepatotoxicity due to allyl alcohol in deermice depends on alcohol dehydrogenase.the role of alcohol dehydrogenase in the hepatic necrosis due to allyl alcohol was studied in two strains of the deermouse, peromyscus maniculatus. mice of the alcohol dehydrogenase-negative (adhn) strain which lack alcohol dehydrogenase activity were resistant to allyl alcohol toxicity. in contrast, dose-dependent necrosis of periportal regions of the liver and increases in plasma levels of lactate dehydrogenase, sorbitol dehydrogenase and sgot were observed in plasma from alcohol dehydrogenase ...20132933316
modoc-like virus isolated from wild deer mice (peromyscus maniculatus) in alberta.small mammals were trapped in northeastern alberta, canada during 1976. blood samples from these animals were tested for virus by inoculation of suckling mice. blood clots from two deer mice yielded isolates of the same virus. the virus was related antigenically to a number of flaviviruses which have been isolated from mammals in central america and north america and was related most closely to modoc virus. physical, chemical, and biological properties of the virus were similar also to those of ...19852987550
differential opiate influences on food hoarding and intake in the deer mouse, peromyscus maniculatus.the feeding behavior of the deer mouse, peromyscus maniculatus, includes food hoarding as well as ingestion. in this animal the mu opiate agonist, morphine, and the kappa opiate agonist, u-50, 488h, selectively stimulate food hoarding and ingestion, respectively. this suggests that mu and kappa opiate systems may differentially mediate primary components of natural feeding behavior.19852999543
immunosuppression in experimental trypanosomiasis: effects of trypanosoma equiperdum on the pathogenesis of influenza virus infection in deer mice (peromyscus maniculatus).the effects of trypanosoma equiperdum infections on the immunological and pathological responses of deer mice (peromyscus maniculatus) to influenza virus exposure were investigated. mice carrying a 5 week trypanosome infection along with an age- and sex-matched trypanosome-free control group were simultaneously exposed to influenza ao (wsn) virus. t. equiperdum infection significantly (p less than 0.01) converted a sub-lethal virus attack into a fatal pneumonic process in a small proportion of a ...19853002002
food hoarding and ingestion in the deer mouse, peromyscus maniculatus: selective responses to mu and kappa opiate agonists.the feeding behavior of the deer mouse, peromyscus maniculatus, includes food hoarding as well as ingestion. administration of the prototypical mu opiate agonist, morphine sulfate, 1-20 mg/kg, produced over three hours a significant dose-dependent stimulation of hoarding by free feeding deer mice. the specific kappa opiate agonist, u-50,488h, 0.10-10 mg/kg, markedly increased ingestion without having any augmentatory effects on hoarding. the mixed mu and kappa opiate agonist, ketocyclazocine hyd ...19863022306
experimental infection and horizontal transmission of modoc virus in deer mice (peromyscus maniculatus).deer mice (peromyscus maniculatus) were inoculated with a sublethal dose of a field strain of modoc virus to determine patterns of viral persistence, shedding, and transmission. blood, serum, urine, fecal, and oral swab samples were collected at selected intervals until 63 days postinoculation (pi) after which lung, liver, spleen, kidney, and salivary glands were explanted. viral assays were conducted by intracranial inoculations of suckling mice and antibody titers were determined by the micro- ...19873035240
kinship, familiarity, aggression, and dominance in deer mice (peromyscus maniculatus) in seminatural enclosures.this study was designed to test the effects of kinship and postweaning familiarity on male-male aggressive interactions in deer mice (peromyscus maniculatus) in a more naturalistic situation than that of most tests of kin discrimination. familiar males (i.e., those housed together from weaning) displayed significantly less aggression than unfamiliar males; kinship per se did not appear to affect levels of aggression. in addition, dominant males copulated more than subordinates and under some con ...19883165063
vertical distribution of soil removed by four species of burrowing rodents in disturbed and undisturbed soils.burrow volumes were determined in disturbed and undisturbed soils for four species of rodents in southeastern idaho. comparisons were made between soil types for the average volume and the proportion of the total volume of soil excavated from 10-cm increments for each species, and the relative number of burrows and proportion of total soil removed from beneath the minimum thickness of soil covers over buried low-level radioactive wastes. burrows of montane voles (microtus montanus) and deer mice ...19883280518
novelty-induced opioid analgesia in deer mice (peromyscus maniculatus): sex and population differences.exposure to a new environment elicited significant, naloxone (1.0 mg/kg) reversible analgesic responses in three different populations of deer mice; peromyscus maniculatus artemisiae from the mainland, and p. m. angustus and p. m. triangularis from small marine islands. in all cases male deer mice displayed significantly greater levels of analgesia than females. in addition, the levels of analgesia were significantly greater in the insular than in the mainland populations. these results indicate ...19883345191
influence of photoperiod, ambient temperature and melatonin on testosterone synthesis and release during reproductive maturation in male deer mice.four experiments were designed to investigate the influence of photoperiod and other environmental factors on androgen production and reproductive maturation in deer mice. male prairie deer mice (peromyscus maniculatus), born in a light/dark cycle of 6l:18d, either remained in this short photoperiod or were switched to a long day regimen of 16l:8d at weaning. in a cross-sectional experiment, the deer mice were killed between 3 and 8 weeks of age for measurement of serum testosterone concentratio ...19883346178
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