Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| the arrangement of subunits in cholera toxin. | cholera toxin consists of five similar b subunits of apparent molecular weight about 10 600 and one a subunit (29 000) consisting of two peptides (a1 23 000-24 000 and a2 about 5500) linked by a single disulfide bond. each b subunit also contains one internal disulfide bond which is readily reduced but is protected from carboxymethylation unless the reduced subunits are heated in urea. tyrosine residues in a1 and in b subunits are readily iodinated, but the intact b assembly does not react with ... | 1976 | 3214 |
| properties of cholera toxin- and naf-stimulated adenylate cyclase from mouse thymocytes. | kinetic parameters of mouse thymocyte adenylate cyclase activity were determined. naf and cholera toxin stimulated adenylate cyclase. stimulation by either agent did not change the ph or mg2+ optima relative to control (unstimulated cyclase). the km value for atp of adenylate cyclase stimulated by naf was significantly reduced from control. by contrast, cholera toxin treatment did not change the km relative to control. adenylate cyclase, when stimulated by naf, had an optimum for mn2+ alone, or ... | 1976 | 3217 |
| analysis of the data in the literature on the sensitivity of cholera vibrios to tetracycline. | variation diagrams were proposed to be used for the analysis of the published data on the study of vibrio cholerae sensitivity to tetracycline. the diagrams provided systematization of dissimilar data of the experimental studies and a unique system of estimation was created. the analysis of the systematized data provided dividing of the vibrio cholerae strains tested into 4 groups differing in the levels of their sensitivity to tetracycline. the groups were independent of the vibrio cholerae bio ... | 1975 | 5050 |
| interaction of cholera toxin and toxin derivatives with lymphocytes. ii. modulating effects of cholera toxin on in vivo humoral and cellular immune responses. | the in vivo effects of cholera toxin on lymphoid organ structure and function in mice were investigated. it was found that within a day following intravenous injection of 1 mug of toxin, thymus as well as spleen weight decreased but the animals remained healthy. histological studies suggested that the involution of lymphoid organs was due to cell death. injection of cholera toxin into adrenalectomized mice was lethal within 36 h. in these animals no decrease in lymphoid organ weight was noted. t ... | 1976 | 5378 |
| comparative study of the proteinograms of vibrios and of closely related microorganisms by means of polyacrylamide gel disc electrophoresis. | proteinograms of 112 strains of vibrios and closely affiliated microorganisms were studied by disc electrophoresis in polyacrylamide gel. up to 25 protein peaks with definite mobility coefficients were revealed. the influence of the culture medium on the protein spectrum of the microbes was found. the frequency of peak formation was of great significance for the differentiation of the microbes under study. the quantitative characteristics of the peak area could not be used for differentiation. | 1976 | 7908 |
| molecular weight analysis of the polypeptides of cholera phage pl 163/10 by polyacrylamide gel electrophoresis. | cholera phage pl 163/10, belonging to mukerjee's group i, was purified by alternate cycles of low and high speed centrifugation. gel electrophoresis revealed the presence of four polypeptide chains of respective molecular weights of 10,370+/-515 (a), 30,000+/-1,303 (b), 40,000+/-1,049(c) and 64,000+/-2,433 (d) daltons. electrophoresis of the sample alkylated with iodoacetic acid resolved the presence of only one polypeptide chain of an average molecular weight of 10,310+/-565 daltons. the polype ... | 1976 | 9816 |
| use of thyrotropin and cholera toxin to probe the mechanism by which interferon initiates its antiviral activity. | thyrotropin (10 mum) inhibited the antiviral activity of interferon. when added after interferon, thyrotropin (tsh) had no effect on antiviral activity. there was also no inhibition of interferon action in cells washed with medium between incubations with tsh and interferon. 125i-labeled tsh and 125i-labeled cholera toxin could bind to preparations of mouse l-cell plasma membranes. the binding was specific in that it was prevented by unlabeled thyrotropin or cholera toxin, but not by insulin, gl ... | 1976 | 10573 |
| antibacterial activity of ambodryl and benadryl. | 1976 | 11202 | |
| effect of caffeine on the motility, viability, oxygen consumption and glycolytic rate of ejaculated human normokinetic and hypokinetic spermatozoa. | in this report the effect of caffeine, ibmx and cholera toxin on ejaculated human spermatozoa was tested. it was found that caffeine was the most effective drug, and that cholera toxin was ineffective. caffeine stimulated motility, preserved viability and increased the glucose, fructose utilization and lactate production of sperm in whole semen and washed sperm. oxygen consumption however was decreased. these results of the normokinetic ejaculates were defined as a basis for comparison with the ... | 1976 | 12119 |
| effect of gangliosides and substrate analogues on the hydrolysis of nicotinamide adenine dinucleotide by choleragen. | choleragen and its a protomer catalyzed the hydrolysis of nad to adp-ribose and nicotinamide. nadase activity was inhibited by gangliosides gm1 (galactosyl-n-acetylgalactosaminyl-n-acetylneuraminyl-galactosylglucosylceramide), gm2 (n-acetylgalactosaminyl-n-acetylneuraminyl-galactosylglucosylceramide), gm3 (n-acetylneuraminyl-galactosylglucosylceramide), and gd1a (n-acetylneuraminylgalactosyl-n-acetylgalactosaminyl-e1n-acetylneuraminyl-galactosylglucosylceramide). these gangliosides also increase ... | 1977 | 13371 |
| effect of cholera enterotoxin preparations on cutaneous response in rabbit under varied conditions. | enterotoxic activity of two preparations obtained from vibrio cholerae, b-53-6 inaba and b-53-10 ogawa was tested in ligated ileal loops of rabbit. the biologically active enterotoxic preparations were further used to study the permeability reaction in rabbit skin. cutaneous response tended to be linear only with higher concentrations of the toxin and showed maximum blueing intensity between 16 and 24 hrs of intracutaneous inoculation. exposure of enterotoxin preparations to elevated temperature ... | 1976 | 13591 |
| mechanism of action of beta-blockers in hypertension. | 2001 | 14643 | |
| light-activated calcium release from sonicated bovine retinal rod outer segment disks. | calcium trapped within sonicated and resealed bovine rod outer segment disks is released upon light exposure with a stoichiometry of 0.75 +/- 0.05 calcium for each rhodopsin bleached. the amount of calcium liberated is proportional to the amount of bleaching in the range of 20 to 100% bleaching and is relatively insensitive to the internal trapped calcium concentration. the results are obtained using a flow system in which the disk membrane vesicles are adsorbed on glass particle supported by a ... | 1977 | 14680 |
| three types of paranoid processes. | in classical descriptive psychiatry the term 'paranoid' is often used ambiguously -- referring to a variety of clinical processes which should be more clearly differentiated. specifically, in this paper, we have differentiated three distinct sets of clinical phenomena all usually lumped together as 'paranoid': 1. paranoid from a sense of guilt, 2. paranoid from a sense of low self-esteem, and 3. paranoid from a sense of persecution. these three processes are distinct descriptively, dynamically a ... | 2000 | 14813 |
| serum gastrin levels before and after 6 weeks of cimetidine therapy in patients with duodenal ulcer. | fasting serum gastrins were carried out at the beginning and end of a 6-week double-blind trial of cimetidine and placebo in 30 patients with duodenal ulcer. cimetidine did not cause any significant change in fasting serum gastrin levels after 6 weeks of therapy. | 2000 | 14861 |
| possible subdivisions among alpha-adrenoreceptors in various isolated tissues. | the ratio (expressed in log10 units) of the equieffective concentrations of (+)- and (-)-noradrenaline has been measured in a variety of isolated tissues in the presence of cocaine (1 x 10(-5) m), tropolone (3 x 10(-5) m) and (+/-)-propranolol (5 x 10(-7) to 5 x 10(-5) m). the values obtained fall into 3 distinct and statistically different groups. firstly, a high group comprising (mean +/- s.e.) mouse vasdeferens (2-78 +/- 0-04), rabbit duodenum (2-91 +/- 0-07) and ileum (2-86 +/- 0-05). second ... | 1977 | 15074 |
| ph measurements in the vascular wall of dogs with electrically induced thrombosis of the femoral artery. | electrically induced thrombosis is often used for pathophysiologic and therapeutic experiments. the ph value of the vascular wall was measured to approach the features of this thrombosis. after inducing thrombosis by direct current, ph value of the intima of femoral artery was found decreased. the anode was inserted in the lumen. as to the behavior of the ph value, electric thrombosis and clinical thrombosis are similar. electric thrombosis therefore seems to be valuable for comparing investigat ... | 1977 | 15352 |
| gas levels and biochemical changes in cerebrospinal fluid after experimental brain injury: its effect on cerebral circulation and cerebral metabolism as well as its management. | 1. after brain damage experimentally induced by balloon compression, liquor of the cistern shows a metabolic acidosis with significantly increased lactate level and l/p quotient, and statistically distinct decrease of ph, oxygen tension, and bicarbonate level. 2. there is a considerable disproportion between the changes of acid-base metabolism, gas tension, and metabolic products in cerebrospinal fluid compared with much less expressed disturbances in the blood. 3. the advanced edematous phase s ... | 1976 | 15353 |
| a plausible sequence of the conformational changes of hemoglobin induced by oxygenation. | 2000 | 15522 | |
| purification and properties of the methane mono-oxygenase enzyme system from methylosinus trichosporium ob3b. | 1. a three-component enzyme system that catalyses the oxidation of methane to methanol has been highly purified from methylosinus trichosporium. 2. the components are (i) a soluble co-binding cytochrome c, (ii) a copper-containing protein and (iii) a small protein; the mol. wts. are 13 000, 47 000 and 9400 respectively. the cytochrome component cannot be replaced by similar cytochrome purified from pseudomonas extorquens or by horse heart cytochrome c. 3. the stoicheiometry suggests a mono-oxyge ... | 1977 | 15544 |
| ectopic pregnancy in southern iran: a statistical review of 96 cases. | a review is presented of 96 cases of ectopic pregnacy over a 7-year period. it is noted that in recent years the incidence of this problem has increased. inadequately diagnosed and treated pelvic inflammatory disease has been found to be the main predisposing factor (40%). the rate of extra-uterine gestation was 1:336 deliveries. in this study, previous fertility was high, and primigravidae constituted only 10.4% of the total. the effect of previous pelvic operations and pelvic infection is disc ... | 1999 | 15916 |
| hormonal control of zinc uptake and binding in the rat dorsolateral prostate. | the zinc uptake in the dorsolateral prostate of rats was studied after different hormonal manipulations. orchiectomy reduced the uptake of 65zn. administration of estradiol benzoate to orchiectomized rats doubled the 65zn uptake, a phenomenon which was not observed in orchiectomized-adrenalectomized rats. adrenalectomy in orchiectomized rats had no effect on the concentration of radioactivity beyond the castration-induced decrease. a prolactin release inhibitor, 6-methyl-8-erogelenylacetamide, r ... | 1977 | 15955 |
| spatial distribution of functional oh- carriers along a characean internodal cell: determined by the effect of cytochalasin b on h14co3- assimilation. | 2000 | 16139 | |
| external baccalaureate degrees for physician assistants. | 2000 | 16251 | |
| alpha-isopropylmalate synthase from alcaligenes eutrophus h 16 i. purification and general properties. | alpha-isopropylmalate (ipm) synthase, the first enzyme in the biosynthesis of l-leucine, was purified to a specific activity of 12 micronmole/min x mg protein from the valine-isoleucine double auxotrophic mutant a-81 of the hydrogen bacterium alcaligenes eutrophus h16. the activity in crude extracts of derepressed cells was 0.106 micronmoles of isopropylmalate formed per min and per mg protein. gel electrophoresis and regel electrophoresis of the isolated main band resulted in several distinct b ... | 1977 | 16576 |
| purification and properties of a membrane-associated, folate-binding protein from lactobacillus casei. | a folate-binding protein has been solubilized from lactobacillus casei by treatment of membrane preparations with triton x-100 in the presence of 3hfolate. the protein-folate complex was purified 100-fold and recovered in a 22% yield by adsorption and elution from microgranular silica (quso g-32), followed by passage through sephadex g-150. when subjected to sodium dodecyl sulfate/polyacrylamide gel electrophoresis, the purified preparations showed only a single, protein-staining band whose mole ... | 1977 | 16917 |
| adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of s49 mouse lymphoma cells. | a novel variant of the s49 mouse lymphoma has been selected from wild-type cells by growth in medium containing the beta-adrenergic agonist terbutaline and inhibitors of cyclic nucleotide phosphodiesterase. in contrast to the situation in the wild-type clone, synthesis of adenosine 3':5'-monophosphate (cyclic amp) is not stimulated by beta-adrenergic agonists or by prostaglandin e1 either in intact variant cells or in membrane preparations of such clones. however, basal and naf-stimulated activi ... | 1977 | 17119 |
| studies in acid-base balance. i. effect of alkali therapy in newborn dogs with mechanically fixed ventilation. | the effect of rapid or slow infusion of hypertonic sodium bicarbonate on acid-base balance and serum osmolality was studied in 36 acidotic newborn dogs. respiratory acidosis and hypoxia were produced by mechanically fixed hypoventilation. one group of animals breathed 100% o2 to prevent hypoxemia. rapid infusion of hco3- in acidotic and hypoxic animals resulted in only a transient (1 minute) and small (0.05 ph units) elevation of arterial ph followed by a continuous fall, resulting in a lower ph ... | 1977 | 17663 |
| the use of behavioral checklists to assess physical examination skills. | 1999 | 17754 | |
| [surgical management of thoracic and thoraco-abdominal injuries]. | from 1970 to 1974 407 patients with thoracic injuries have been treated by the authors in the 2nd surgical and thoracic surgical department of the "jános" hospital, budapest--out of them 190 patients were classified as severely injured. the material and the operative technique in isolated thoracal and combined thoracal-abdominal injuries are discussed. the importance of the operative stabilization of the thoracic wall is emphasized and fixation of the thoracic wall by means of pericostal sutures ... | 1999 | 17790 |
| cyclic guanosine-3',5'-monophosphate--mediator of the action of the hormaone erythropoietin. | 1977 | 18327 | |
| value of sputum culture in diagnosis of pneumococcal pneumonia. | in our laboratory, culture of sputum was extremely useful in diagnosing the etiology of pneumococcal pneumonia. of 31 consecutive patients with bacteremic pneumococcal pneumonia, 29 (94%) had streptococcus pneumoniae cultured from sputum. recovery of pneumococci in culture was enhanced by anaerobic incubation as well as by a plate bile test and an optochin disk on a primary blood agar plate. | 1977 | 18489 |
| relative effectiveness of primidone (mysoline) and diphenylhydantoin (dilantin) in the management of sedative withdrawal seizures. | 2000 | 18975 | |
| pyruvate kinase from the moderate halophile, vibrio costicola. | 1977 | 19142 | |
| effect of prolonged gestation on placental and maternal liver enzyme activities in the rat. | 1977 | 19310 | |
| degradation kinetics of a substituted carbinolamine in aqueous media. | the apparent first-order breakdown of the medicinally active agent 3-(p-chlorophenyl)-2-ethyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazol-3-ol was studied in aqueous solutions where dehydration gave the unsaturated compound 3-(p-chlorophenyl)-5,6-dihydro-2-ethylimidazo[2,1-b]thiazole. this thiazole was the primary solvolytic product produced in approximately quantitative yields for the temperature range studied and ostensibly underwent no further reaction in acidic media even on prolonged heating. i ... | 1997 | 19617 |
| a new design of glass micro-electrode for extracellular ph measurement [proceedings]. | 1997 | 19622 | |
| comparison of specificity of agonist and antagonist radioligand binding to beta adrenergic receptors. | 1998 | 19707 | |
| the identification of lipid acceptor and the biosynthesis of lipid-linked glucose in bacillus stearothermophilus. | 1977 | 20047 | |
| the use of titanium (iv) oxide for the immobilisation of carbohydrate-directed enzymes. | the use of particles of porous titanium (iv) oxide as a suitable matrix for enzyme immobilisation has been investigated with dextranase. treatment of the particles with enzyme in the presence and absence of ammonium ions showed that the presence of ammonia induced a greater coupling of protein, whereas a greater retention of enzyme specific activity was achieved in the absence of ammonia. properties of the immobilised enzyme include a ph-dependence and reversibility of the coupling between enzym ... | 1998 | 20228 |
| simple method for preparation of immune sera to envelope and nucleocapsid antigens of semliki forest virus. | immune sera to the envelope and nucleocapsid components of zaisan 260 and r 16225 strains of semliki forest virus (sfv) were prepared with the use of disrupted, partially purified virus. | 1977 | 20771 |
| permeability of amino acids into liposomes. | 1. a simple and rapid assay for the measurement of permeability of amino acids into liposome membrane was carried out by using the liposomes trapping d-amino acid oxidase (d-amino acid: o2 oxidoreductase (deaminating), ec 1.4.3.3) inside the membrane. 2. permeability of amino acids into liposomes depended on the lipid composition of the membrane. permeability of amino acids into phosphatidylcholine-cholesterol liposomes depended critically on temperature. 3. permeability also depended on the str ... | 1998 | 21692 |
| studies on phosphate-solubilizing bacteria in soil and rhizosphere of different plants. ii. selection of the most efficient phosphate-dissolvers and their morphological grouping. | two hundred colonies which showed positive reaction on the plates prepared for the phosphate-dissolving bacteria from control soil rhizosphere soils and rhizoplane samples of maize, peas, or cotton were isolated at random. fifty isolates were selected as the most efficient isolates according to their capability for increasing the amounts of available phosphorus in the media with corresponding decreases in ph values. the percentage of the most efficient isolates differed according to type of plan ... | 1999 | 22210 |
| catecholamines and hyperthyroidism. | 1999 | 22414 | |
| narcotic cueing properties of intraventricularly administered sufentanil, fentanyl, morphine and met-enkephalin. | the narcotic cueing activity of sufentanil, fentanyl, morphine and met-enkephalin was studied upon their injection into the lateral brain ventricle of the rat. comparative studies on the analgesic activity of the three narcotics support a close correlation between the narcotic cueing and the analgesic activity of narcotic drugs. | 1978 | 22444 |
| calf liver nuclear n-acetyltransferases. purification and properties of two enzymes with both spermidine acetyltransferase and histone acetyltransferase activities. | calf liver contains two nuclear n-acetyltransferases which are separated by chromatography on hydroxylapatite. both acetyltransferase a and acetyltransferase b will transfer acetate from acetyl-coa to either histone or spermidine. the same protein catalyzes the reaction with both substrates; this is shown by a constant ratio of spermidine to histone activity over a 5,000-fold purification and identical heat denaturation kinetics for both spermidine and histone acetyltransferase activity with eac ... | 1978 | 22543 |
| effect of 5,6-dihydroxytryptamine on the head twitches induced by 5-htp, 5-ht, mescaline and fludiazepam in mice. | 1998 | 22729 | |
| inosine analogs as substrates for adenosine kinase--influence of ionization of the n-1 proton on the rate of phosphorylation. | 1999 | 23125 | |
| antihypertensive drugs: clinical pharmacology and therapeutic use. | 1997 | 23284 | |
| antigenicity of a spontaneous murine mammary adenocarcinoma during in vitro cultivation. | 1977 | 23597 | |
| uric acid calculi: results of conservative treatment. | a total of 140 patients with uric acid diathesis have been treated for the last five years with a standardized mixture of sodium and potassium citrate and citric acid (uralyt u) together with forced fluid intake and, if necessary, the addition of allopurinol. the results have been encouraging; 80 per cent of the patients showed complete dissolution of the stones and relief of symptoms. | 1997 | 23599 |
| [detection of female heterozygous glucose-6-phosphate dehydrogenase deficiency]. | diagnostics of heterozygotes are required for population studies, for the detection and consultation of persons with g-6-pd deficiency prone to hemolysis. the diagnostics of heterozygous females with the corresponding trait are problematic in families without hemizygous patients. 1. the determination of the activity is only applicable to the differentiation between heterozygotes and homozygotes if the activities are below the reference range. heterozygous g-6-pd deficiency with normal activity c ... | 1998 | 23637 |
| evaluation of the effectiveness of receptor destroying enzyme preparations. | a procedure has been developed for testing receptor destroying enzyme (rde) preparations used to remove nonspecific inhibitors before carrying out haemagglutination inhibition tests with influenza virus. four criteria should be taken into account: (1) titre of rde, usually used to indicate the activity of the preparation; (2) neuraminidase activity of the preparation, determined biochemically, which partially corresponds to the rde titre; (3) direct demonstration of the complete removal of nonsp ... | 1977 | 23666 |
| the use of relaxation and desensitisation techniques in eliminating a sleep problem. | this study describes the treatment of a 16-year-old youth unable to sleep, failing to respond to sleeping pills, who on a programme of relaxation and desensitisation in six weeks was able to control his sleeping patterns. on followup four months, six months and twelve months later this ability had been maintained. | 1999 | 24192 |
| congenital testicular lymphangiectasis. | testicular lymphangiectasis are described for the first time in a patient with bilateral inguinal cryptorchidism. a great number of irregular lymphatic channels was observed within the parenchyma and the tunica vasculosa in both testes. large and numerous anastomosis between the lymphatic vessels of these two areas could also be seen. the mtd and the tfi of the left testis were normal. both parameters were very low in the right testis. the association of this fact with the greater development of ... | 1997 | 24294 |
| [treatment principles in arterial hypertension]. | 1997 | 24296 | |
| [disturbances in phosphate metabolism during parenteral alimentation. hypophosphatemic syndrome]. | 1998 | 24396 | |
| modification of the immunologic properties of the cell surface. | living cf1 mouse-transplantable spontaneous mammary adenocarcinoma cells were modified with glutaraldehyde, formalin, 2,4,6-trinitrophenylate, vibrio cholerae neurominidase, iodoacetate, heparin, histamine and adenosine 3'5'-monophosphate (camp), then used to immunize syngeneic cf1 mice. animals immunized with the fixed (formalinized or glutaraldehyde fixed) neuraminidase-treated cells or the membrane of these cells, rejected two challenging doses of 10(8) viable unmodified adenocarcinoma cells. ... | 1978 | 24583 |
| studies on aronson's media with special reference to its utility in laboratory diagnosis of vibrio cholera. | 1977 | 24589 | |
| a galactose specific agglutinin, a blood-group h active polysaccharide, and a trypsin inhibitor in albumin glands and eggs of arianta arbustorum (helicidae). | 1978 | 24667 | |
| capacity for postradiation recovery in bacteria of the genus vibrio when gamma-irradiated cells are incubated in phosphate buffer (ph 8.6) and inoculated on different nutrient media. | 1978 | 24863 | |
| direct evidence of two types of beta adrenoceptor binding site in lung tissue. | 1978 | 25391 | |
| recurrent genital candidosis in women and the effect of intermittent prophylactic treatment. | 1978 | 26452 | |
| a simplified assay of furosemide in plasma and urine by high-pressure liquid chromatography. | a simplified high-pressure liquid chromatograhic method for determination of furosemide in plasma and urine has been developed using a fluorometric detector directly coupled to the column effluent. the method includes an ether extraction from acidified biologic samples. the mobile phase used for chromatography on a reversed-phase column (c15 hydrocarbon permanently bonded to silica particles) is sufficiently acidic to induce fluorescence of furosemide. the methylester of furosemide is employed a ... | 2000 | 26691 |
| [détermination of salivary ph by contact ph metry. study of ph on the tongue and of the orifices of wharton's and stenon's ducts]. | the authors describe an electrochemical technique for the measurement of salivary ph by contact. they present a critical study fo 167 cases. the values obtained are characteristic in terms of age and the site of determination (dorsal surface of the tongue, orifice of wharton's or stenon's ducts). | 2000 | 26965 |
| pus, deoxyribonucleic acid, and sputum viscosity. | on 100 sputum specimens selected from patients suffering from chronic bronchitis, bronchiectasis, asthma, and cystic fibrosis total deoxyribonucleic acid (dna) content has been related to macroscopic type, to total dry weight yield, and to the apparent viscosity of the secretion at 1350 s-1: since dna may be present, either as fibres or within cells, in one-third of the specimens the contribution of each form to the apparent viscosity was assessed. the effect on sputum viscosity of the addition ... | 2000 | 26989 |
| neurochemical and operant behavioral studies of a strain of alcohol-preferring rats. | the levels of serotonin (5-ht), 5-hydroxyindoleacetic acid, tyrosine (tyr), norepinephrine (ne), acetylcholine, gaba, glutamate (glu), aspartate (asp), alanine, glycine (gly) and taurine were measured in the cns of adult male rats selectively inbred to the f8 generation for alcohol preference (p) and non-preference (np). with respect to the values found in the np group, higher levels of 5-ht, gaba, glu and gly and lower levels of asp were found in the diencephalon-mesencephalon (d-m) and higher ... | 1978 | 27820 |
| [treatment of pain with psychotropic drugs (author's transl)]. | 30 patients suffering from therapy-resistant chronic pain were divided into three groups according to drive and mood: i. psychomotor inhibition combined with depressive mood, ii. agitation and depressive mood, iii. agitation combined normal mood. the psychopharmacological treatment of pain showed sufficient results, when the drugs were directed to the target symptoms "agitation", "lack of drive", and "depression". the differentiated administration of activating or sedative antidepressants and ne ... | 2000 | 27829 |
| [acute renal insufficiency in hemorrhagic fever with nephrotic syndrome]. | 2000 | 27875 | |
| influence of tonicity and ph on lacrimation and ocular drug bioavailability. | 1978 | 29087 | |
| purification of a subtilisin inhibitor from black bean seeds. | 2001 | 29779 | |
| flufenamic acid inhibition of pge2 production by rectal mucosa in ulcerative colitis. | 2001 | 29819 | |
| effects of psychotropic drugs on the spinal ventral root reflexes in cats. a comparison of the depressant actions in intact and spinal preparations (author's transl). | effects of the typical psychotropic drugs such as neuroleptics, tricyclic antidepressants and benzodiazepines on the monosynaptic reflex (msr) and polysynaptic reflex (psr) were investigated using intact and spinal cats. drugs used were chlorpromazine, levomepromazine, perphenazine, prochlorperazine, droperidol, haloperidol, amitriptyline, imipramine, diazepam and flurazepam. neuroleptics depressed the ventral root reflexes markedly to slightly in both preparations. the inhibitory effects of the ... | 1978 | 29826 |
| the hypothalamo-hypophysial system: model for central peptidergic and monoaminergic transmission. | 2001 | 29844 | |
| [clinical pharmacology of beta-adrenoreceptor blockaders]. | 2001 | 29848 | |
| red cell aging. ii. anomalous electrophoretic properties of neuraminidase treated human erythrocytes. | desialylation of human red blood cells (rbc) by vibrio cholerae neuraminidase (vcn) was found to produce cells with electrophoretic properties which were inconsistent with the view of simple loss of n-acetylneuraminic acid (nana) as the sole effect of vcn treatment. modification of human rbc with 50--350 u vcn/10(10) rbc for one hour at 37 degrees c releases 90-100% of the nana and produces a progressive decrease towards zero in their electrophoretic mobilities when measured in 0.15 m nacl (ph 7 ... | 1978 | 29906 |
| the regulation of intracellular calcium by mitochondria. | 1978 | 30378 | |
| growth yield and efficiency in chemosynthetic microorganisms. | 2001 | 30389 | |
| the fluorescence of fluorescamine-amino acids. | 2001 | 30402 | |
| effect of endogenous and exogenous progesterone on human endometrial enzymes. | activities of 9 enzymes were determined biochemically in the endometrium. in trial i (five women) 25 mg progesterone were injected i.m. on day 9 of the cycle; and endometrial biopsy taken 24 hours later was compared with endometrium from day 10 and day 21, taken in two untreated cycles from the same volunteers. similarly, in trial ii (five women) 50 mg progesterone were injected on day 9, biopsy taken on day 11 and compared with days 11 and 21 from untreated cycles. the specific activites of lac ... | 1978 | 30706 |
| blockade by n-methylhydroxylamine of activation of guanylate cyclase and elevations of guanosine 3',5'-monophosphate levels in nervous tissues. | hydroxylamine and n-methylhydroxylamine prevented the activation of soluble guanylate cyclase by the endogenous activator as well as by nitroso compounds such as n-methyl-n'-nitro-n-nitrosoguanidine or nitroprusside, while other derivaties of hydroxylamine were ineffective. hydroxylamine and n-methylhydroxylamine did not alter the basal guanylate cyclase activity of purified enzyme preparations. kinetics analysis indicated that n-methylhydroxylamine competes with n-methyl-n'-nitro-n-nitrosoguani ... | 1978 | 31192 |
| cigarette smoking: a dependence on high-nicotine boli. | 2001 | 31270 | |
| the neurochemistry of learning and memory. | the neurochemical basis of memory has been approached experimentally in four different ways: the bioassay; the interventive approach; the interventive-correlative approach; and the correlative approach. these approaches are fundamentally similar to those used for the study of the chemistry of any behavior. each of these approaches has serious limitations, and significant progress has only been made by combinations of more than one. i shall discuss each of these approaches in turn. | 2001 | 31280 |
| (exo, exo)-2-aryltropane-3-carboxylic esters, hypoglycemic agents with accompanying analgesic activity. | (exo, exo)-2-aryltropane-3-carboxylic esters of types 6, 7, and 10 lower circulating blood glucose levels by 60--80%. this activity is accompanied by an analgesic activity roughly equal to that of codeine. both of these activities reside in the 1r enantiomer and extensive structure-activity studies failed to separate them. the specific opioid antagonist nalorphine blocks the analgesic activity but does not diminish the hypoglycemic action. conformational integrity afforded by the ethylene bridge ... | 1978 | 31482 |
| mechanisms of action of cholera and escherichia coli enterotoxins. | current information is reviewed on the mechanism of secretion in small intestine, including how it is altered by cyclic 3',5'-adenosine monophosphate and on the structures and properties of cholera and both heat-labile and heat-stable escherichia coli enterotoxins. two separate active ion transport processes are altered by cyclic 3',5'-adenosine monophosphate: 1) coupled absorption of nacl is inhibited in villus cells and 2) active anion secretion is stimulated, probably in crypt cells. cholera ... | 1979 | 32766 |
| characteristics of a cholera phage. | the basic physical, chemical and physiological properties of a group ii cholera phage belonging to mukerjee's classification has been described. | 1978 | 32857 |
| purification and properties of human erythrocyte inosine triphosphate pyrophosphohydrolase. | inosine triphosphate pyrophosphohydrolase from human erythrocytes was purified and characterized. the enzyme is highly specific for itp and shows optimal activity in glycine buffer ph 9.6 and 50 mm mgcl2. the km of the enzyme is 1.3 x 10(-4), the vmax = 1.2 x 10(-9) and the keq = 3.8 x 10(4). human erythrocyte itp pyrophosphohydrolase does not require sh compounds for activation. the enzyme is inhibited by cd++, co++, and ca++ ions and by p-hydroxymercuribenzoate. | 1979 | 33191 |
| analysis of cysteinyldopas, dopa, dopamine, noradrenaline and adrenaline in serum and urine using high-performance liquid chromatography and electrochemical detection. | the catecholic amino acids, dopa, 2-s- and 5-s-cysteinyldopa, and 2,5-s,s-dicysteinyldopa were determined qualitatively in serum from patients with malignant melanoma by reversed-phase high-performance liquid chromatography, using electrochemical detection. in urine the catecholamines dopamine, noradrenaline and adrenaline were also determined qualitatively, as well as the above-mentioned compounds, in a single chromatographic run. the conditions were optimized by changing the ph of the mobile p ... | 2001 | 33194 |
| kinetic studies in isolated organs: tools to design analgesic peptides and to analyze their receptor effects. | the opioid activities of peptide and non-peptide narcotics were studied in longitudinal muscle strip of guinea pig ileum (gpi) and in mouse vas deferens (mvd). the comparison of agonist activities of peptides found in gpi and mvd offered the opportunity to predict the presence but not the magnitude of potential analgesic activity. the kinetics of the antagonism between naltrexone and different types of agonists were also determined in these systems. using c-6 epimers of naltrexone, it was found ... | 1979 | 33396 |
| characterization of the in vitro reassembly of tubulin derived from stable strongylocentrotus purpuratus outer doublet microtubules. | 1999 | 33707 | |
| [studies on cardiac principle in aconite roots. i. isolation and structural determination of higenamine (author's transl)]. | 2000 | 34017 | |
| [makeup of a population el tor vibrios according to their agglutinability by type-specific sera]. | the authors studied population composition of 14 strains of el tor vibrios. of 7 strains of ogava serological type the population composition was homogeneous in 2, and heterogeneous in 5. all the 7 strains of el tor vibrios of inaba serological type had homogeneous population composition. changes of the existence conditions of el tor vibrios of ogava serological type, containing in their population 5% cells of hikoshima serological tupe, led to separation of the cells of inaba serological type; ... | 1978 | 34303 |
| immobilization of aminoacylase by adsorption to tannin immobilized on aminohexyl cellulose. | the immobilization of aminoacylase (n-acylamino acid amidohydrolase, ec 3.5.1.14) was investigated by using tannin immobilized on aminohexyl cellulose. the most active immobilized aminoacylase was obtained when aminoacylase was adsorbed to the immobilized tannin in a weak alkaline medium containing sodium chloride and n-butanol at 37 degrees c. the activity of the immobilized tannin-aminoacylase complex per unit volume was five times higher than that of the deae-sephadex-aminoacylase complex use ... | 2001 | 34448 |
| [phenomenon of parental resistance and its genetic regulation]. | lymphocytes of mice f1 (cba x m523) and f1 (a x m523) transplanted to 1000 r irradiated cba or a mice responded to the test antigens--srbc or s. typhi vi-antigen--by formation of 100--1000 times less antibody forming cells than in syngeneic recipients. an intermediate result is achieved when the lymphoid cells are transplanted to the irradiated m523 mice. lymphocytes of mice f1 (a x cba), f1 (cba x c57bl/6), or f1 (a x a.ca) developed a similar immune response in the irradiated syngeneic mice an ... | 1979 | 34452 |
| antivibrionic activity of some glycolytic cycle enzymes of animal cells. | the antivibrionic activity of crystalline preparations of five enzymes of the glycolytic cycle of animals cells was investigated. phosphorylase "a" (0.5 mg/ml), aldolase (15 mg/ml) and pyruvate kinase (0.1 mg/ml) were found to inhibit the proliferation of vibrio cholerae cells; phosphoglucomutase and glyceraldehyde-3-phosphate dehydrogenase at a concentration of 0.25 mg/ml were found to be vibriocidal. a mixture of these enzymes containing 0.062 mg/ml of phosphorylase "a" and 0.125 mg/ml of each ... | 1978 | 34659 |
| disulphide cross-linked macromolecules formed by thiolated insulin and globin. | 2001 | 34704 | |
| international conference on molecular and cellular models of aging. paris, centre national de la recherche scientifique, 5-7 april 1978. abstracts. | 2001 | 35447 | |
| immobilization of neuraminidase and its potential application in the modification of cell surfaces. | vibrio cholerae neuraminidase was immobilized on the inside of 1.0 mm inner diameter nylon tubing with retention of enzyme activity, when assayed at 37 degrees c and ph 5.5 with mucin as substrate. the stabilities of the immobilized and soluble enzymes were similar for up to 3 hr at 37 degrees c. preliminary data indicated that immobilized neuraminidase will release sialic acid from the surface of leukemic akr mouse thymus and spleen lymphocytes; however, the level of immobilized enzyme activity ... | 1979 | 35566 |
| [fractionation of vibrio cholerae enterotoxin by isoelectric focusing in an ampholin gradient]. | 1979 | 36726 | |
| measurement of ionic exchange in organelle suspensions with ion-selective electrodes [proceedings]. | 2001 | 37329 |