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bacillus hunanensis sp. nov., a slightly halophilic bacterium isolated from non-saline forest soil.a novel gram-stain-positive, slightly halophilic, catalase- and oxidase-positive, endospore-forming, motile, aerobic, rod-shaped bacterium, designated strain jsm 081003(t), was isolated from non-saline forest soil in hunan province, china. growth occurred with 0.5-15% (w/v) nacl (optimum 2-4%) at ph 6.5-10.5 (optimum ph 7.5-8.5) and at 5-40 °c (optimum 30 °c). meso-diaminopimelic acid was present in the cell-wall peptidoglycan. the major cellular fatty acids were iso-c15:0, anteiso-c15:0 and iso ...201020872176
hunanamycin a, an antibiotic from a marine-derived bacillus hunanensis.hunanamycin a, the first natural product with a pyrido[1,2,3-de]quinoxaline-2,3-dione core, was isolated from a marine-derived bacillus hunanensis. hunanamycin a is related to a degradation product of riboflavin but has undergone an n-prenylation and subsequent cyclization. the structure, including stereochemistry, was determined by nmr and ms methods. hunanamycin a exhibits a minimum inhibitory concentration (mic) of 12.4 μm against the bacterial pathogen salmonella enterica.201323305153
bacillus shacheensis sp. nov., a moderately halophilic bacterium isolated from a saline-alkali soil.a moderately halophilic bacterium, strain hna-14(t), was isolated from a saline-alkali soil sample collected in shache county, xinjiang province. on the basis of the polyphasic taxonomic data, the isolate was considered to be a member of the genus bacillus. the organism grew optimally at 30 °c and ph 8.0. it was moderately halophilic and its optimum growth occurred at 5-10% nacl. the diamino acid found in the cell-wall peptidoglycan was meso-diaminopimelic acid and the predominant menaquinone wa ...201425008165
first total synthesis of hunanamycin a.the first total synthesis of hunanamycin a, an antibiotic natural product with a pyrido[1,2,3-de]quinoxaline-2,3-dione core from a marine-derived bacillus hunanensis, is disclosed. the present effort provides access to sufficient amounts of scarce hunanamycin a for further biological evaluation and confirmation of the assigned absolute configuration. in addition, four new analogues of the natural product are reported.201323964695
discoipyrroles a-d: isolation, structure determination, and synthesis of potent migration inhibitors from bacillus hunanensis.discoidin domain receptor 2 (ddr2) is a receptor tyrosine kinase involved in a variety of cellular response pathways, including regulation of cell growth, proliferation, and motility. using a newly developed platform to identify the signaling pathway/molecular target of natural products, we identified a family of alkaloid natural products, discoipyrroles a-d (1-4), from bacillus hunanensis that inhibit the ddr2 signaling pathway. the structure of 1-4, determined by detailed two-dimensional (2d) ...201323984625
detailed mechanistic study of the non-enzymatic formation of the discoipyrrole family of natural products.discoipyrroles a-d (dpa-dpd) are recently discovered natural products produced by the marine bacterium bacillus hunanensis that exhibit anticancer properties in vitro. initial biosynthetic studies demonstrated that dpa is formed in the liquid fermentation medium of b. hunanensis from three secreted metabolites through an unknown but protein-independent mechanism. the increased identification of natural products that depend on non-enzymatic steps creates a significant need to understand how these ...201626824832
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