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[effects of petroleum ether extract of peucedanum praeruptorum dunn on rabbit trachea smooth muscles].the contractions of isolated rabbit trachea smooth muscles by acetylcholine and potassium chloride were attenuated by petroleum ether extract of peucedanum praeruptorum pretreatment. the dose-effect curve of acetylcholine was shifted to the right, and the maximal response was diminished. the effect was non-competitive and dose-dependent.19947945886
isolation of praeruptorins a and b from peucedanum praeruptorum dunn. and their general pharmacological evaluation in comparison with extracts of the drug.the root of peucedanum praeruptorum dunn. was extracted with solvents at different polarity obtaining three chemical fractions: aqueous (h2o), n-butanol (buoh) and ethyl acetate (acoet). from acoet praeruptorins a and b were isolated by column chromatography on silica gel, using toluene/ethyl acetate as eluent, and identified by 1h and 13c nmr analysis. the extracts and the praeruptorins were tested for gross behavioural effects and acute toxicity in mice; the cytotoxicity on artemia salina leac ...200111482769
[effects of praeruptorin c on vascular hypertrophy, [ca2+]i, collagen content and no in renovascular and spontaneously hypertensive rats].to study the effects of praeruptorin c (pra-c), a pure constituent isolated from "qian-hu", the roots of peucedanum praeruptorum dunn. (umbelliferae), on vascular hypertrophy, collagen content, transient [ca2+]i, no and vascular response of the thoracic aorta of renovascular and spontaneously hypertensive rats (rhr, shr).200112580080
car-mediated up-regulation of cyp3a4 expression in ls174t cells by chinese herbal compounds.the constitutive androstane receptor (car) is an orphan nuclear receptor which has been shown to participate in the activation of human cyp3a4, which metabolizes more than 50% of clinically used drugs. we investigated the effects of an array of compounds isolated from herbal medicines such as rheum palmatum (da huang), peucedanum praeruptorum dunn (qian hu), cortex mori radicis (sang bai pi), radix asteris (zi wan), salvia miltiorrhiza (dan shen), polygonum cuspidatum sieb. et zucc (hu zhang), a ...201121422673
mumia xiangluensis sp. nov., isolated from the rhizosphere of peucedanum praeruptorum dunn.during an investigation of microbial diversity in medicinal herbs, a novel actinobacterium, strain neau-kd1(t) was isolated from the rhizosphere of peucedanum praeruptorum dunn collected from xianglu mountain in heilongjiang province, northeast china and characterized using a polyphasic approach. the organism was found to have the typical chemotaxonomic and morphological characteristics of the genus mumia. cells were observed to be non-spore-forming and irregular cocci. the cell wall was found t ...201627027520
cloning, functional characterization, and catalytic mechanism of a bergaptol o-methyltransferase from peucedanum praeruptorum dunn.coumarins are main active components of peucedanum praeruptorum dunn. among them, methoxylated coumarin compound, such as bergapten, xanthotoxin, and isopimpinellin, has high officinal value and plays an important role in medicinal field. however, major issues associated with the biosynthesis mechanism of coumarins remain unsolved and no corresponding enzyme has been cloned from p. praeruptorum. in this study, a local blastn program was conducted to find the candidate genes from p. praeruptorum ...201627252733
[semi-synthesis of derivatives with c-3' and c-4' trans-configuration from (+)-praeruptorin a].in order to compare the calcium antagonist activity between the derivatives of (+)-praeruptorin a with c-3' and c-4' cis-configuration and trans-configuration, and to look for new active compounds, some derivatives with c-3', c-4' trans-configuration of (+)-praeruptorin a were semi-synthsized.200312958840
the antagonistic effects of khellactones on platelet-activating factor, histamine, and leukotriene d4.khellactones of peucedanum praeruptorum duun., including praeruptorins a (= pd-ia, 2) and b (= pd-ii,11), had an antagonistic effect specifically on platelet aggregation induced by platelet activating factor (paf) among various aggregating agents examined, and represent a new class of paf antagonists. we examined the effects of twenty compounds on paf-induced platelet aggregation and on histamine- and leukotriene d4 (ltd4)-induced contractions in isolated guinea pig ileum. compounds 2, (+/-)-cis ...19957553972
[isolation and identification of coumarin praeruptorin e from the root of the chinese drug peucedanum praeruptorum dunn (umbelliferae)]. 19827148466
[determination of coumarins in qian-hu, peucedanum praeruptorum, p. decursivum and ligusticum daucoides]. 19846235950
calcium antagonist-like actions of coumarins isolated from "qian-hu" on anaphylactic mediator release from mast cell induced by concanavalin a.the effects of coumarins on anaphylactic mediator release from rat mast cells were investigated. since pd-ia (3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin) causes relaxation of smooth muscle by inhibiting calcium influx, and since mediator release is a calcium-dependent process, studies were made on whether coumarins block calcium influx into rat mast cells stimulated by concanavalin a. pd-ia isolated from peucedanum praeruptorum dunn and related compounds, named pd-c-ii, pd-c-iii and pd-c-iv, ...19852411906
streptomyces castaneus sp. nov., a novel actinomycete isolated from the rhizosphere of peucedanum praeruptorum dunn.during an investigation of microbial diversity in medicinal herbs, a novel actinomycete, strain neau-qhhv11(t) was isolated from the rhizosphere of peucedanum praeruptorum dunn collected from xianglu mountain in heilongjiang province, northeast china and characterized using a polyphasic approach. the organism was found to have typical characteristics of the genus streptomyces. phylogenetic analysis based on 16s rrna gene sequence also indicated that strain neau-qhhv11(t) belongs to the genus str ...201727476065
metabolism of dl-praeruptorin a in rat liver microsomes using hplc-electrospray ionization tandem mass spectrometry.dl-praeruptorin a (pd-ia) is the major active constituent of the traditional chinese medicine peucedanum praeruptorum dunn. recently it has been identified as a novel agent in the treatment and prevention of cardiovascular diseases. accordingly, we investigated the metabolism of pd-ia in rat liver microsomes. the involvement of cytochrome p450 (cyp) and cyp isoforms were identified using a cyp-specific inhibitor (skf-525a), cyp-selective inhibitors (α-naphthoflavone, metyrapone, fluvastatin, qui ...201121910053
chemopreventive effects of peucedanum praeruptorum dunn and its major constituents on sgc7901 gastric cancer cells.in this study, the effects of peucedanum praeruptorum dunn methanolic extract (ppme) and its major constituents on sgc7901 human gastric cancer cells were evaluated. two pyranocoumarins, namely, (±) praeruptorin a (pa) and (±) praeruptorin b (pb), were isolated from ppme. a high performance liquid chromatographic (hplc) method was developed to determine the contents of pa and pb in ppme. the anti-proliferative and cytotoxic actions of ppme were observed using the 3-(4,5-dimethyl-thiazol-2-yl)-2, ...201021063269
pharmacokinetics, tissue distribution and excretion study of dl-praeruptorin a of peucedanum praeruptorum in rats by liquid chromatography tandem mass spectrometry.dl-praeruptorin a (pd-ia), isolated from chinese traditional herbal medicine peucedanum praeruptorum dunn, has been proved to be a novel ca²+-influx blocker and k+-channel opener, and displayed bright prospects in prevention and therapy of cardiac diseases. the aim of this study was to investigate the pharmacokinetics, tissue distribution and excretion of pd-ia in rats following a single intravenous (i.v.) administration. the levels of pd-ia in plasma, tissues, bile, urine and feces were measure ...201021036581
(+/-)-praeruptorin a enantiomers exert distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis.praeruptorin a is a coumarin compound naturally occurring in the roots of peucedanum praeruptorum dunn., a commonly used traditional chinese medicine for the treatment of certain respiratory diseases and hypertension. although previous studies indicated the relaxant effects of (+/-)-praeruptorin a on tracheal and arterial preparations, little is known about the functional characteristics of the enantiomers. in the present study, the two enantiomers were successfully isolated and identified by us ...201020433815
[comparative studies on pharmacological effects of the main chemical constituents of peucedanum praeruptorum from he'nan and jiangxi].to compare the pharmacological effect of the main coumarin constituents of peucedanum praeruptorum from jiangxi and he'nan.200516323547
[studies on structure modification of (+)-praeruptorin a].in order to look for new active compounds, the structure of (+)-praeruptorin a is modified.200212914322
pyranocoumarins isolated from peucedanum praeruptorum as differentiation inducers in human leukemic hl-60 cells.differentiation therapy for myeloid leukemia offers great potential as a supplement to the current treatment modalities. in the present report, we investigated if the pyranocoumarins, (+/-)-4'- o-acetyl-3'- o-angeloyl- cis-khellactone (or angular pyranocoumarin, apc) isolated from the medicinal plant peucedanum praeruptorum dunn, could induce human acute myeloid leukemic hl-60 cells to differentiate and elucidated the molecular mechanism(s) involved. the ability of hl-60 cells to reduce nitroblu ...200312677525
[effects of peucedanum praeruptorum extractum on blood pressure, left ventricular hypertrophy and hemodynamic changes in left ventricular hypertrophied hypertensive rats].after intragastric administration of peucedanum praeruptorum (ppe) 0.6 g/100 g body weight, the blood pressure was decreased significantly in both the normal and the left ventricular hypertrophied hypertensive (lvh) rats. the ppe could still prevent the formation of the left ventricular hypertrophy in renovascular hypertensive rats, the ratio of weight of left ventricular over the weight of body was reduced markedly than that of the lvh group, and was nearly the same of the sham-operated group. ...19969772620
effect of dl-praeruptorin a on calcium current in ventricular cells of guinea pig.with patch clamp technic (whole cell recording), the effect of dl-praeruptorin a (pra), an ingredient of peucedanum praeruptorum dunn on calcium current (ica) in the single ventricular cells of guinea pig was studied. results showed that under cs/cs condition, when the holding potential was -40 mv and in the presence of pra (1, 10, 100 mumol.l-1), ica was decreased dose-dependently from 2.02 +/- 0.24, 2.00 +/- 0.12, 2.12 +/- 0.33 na (control) to 1.60 +/- 0.24, 1.32 +/- 0.08, 1.16 +/- 0.43 na, re ...19947709752
effects of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin on cardiohemodynamics in anesthetized dogs.cardiohemodynamic effects of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin (pd-ia) isolated from the chinese medicinal plant peucedanum praeruptorum dunn were compared with those of diltiazem (dil) in anesthetized open-chest dogs. pd-ia 3 mg.kg-1 increased coronary blood flow from 25 +/- 11 to 58 +/- 16 ml.min-1 (n = 7, p < 0.01) and decreased mean aortic pressure (map) from 13 +/- 2 to 8 +/- 1 kpa (p < 0.01), rate pressure product (rpp) from 1.9 +/- 0.5 to 1.3 +/- 0.3 mpa.bpm (p < 0.05), +dp/d ...19947709748
effects of praeruptorin c and e isolated from 'qian-hu' on swine coronary artery and guinea-pig atria.praeruptorin c and e isolated from peucedanum praeruptorum dunn. decreased the maximum contractile effect of ca2+ in potassium-depolarized swine coronary strips and shifted the concentration-response curve to the right in a non-parallel manner. the calcium antagonistic activity of praeruptorin c and e expressed as pd'2 value was 5.7 and 5.2, respectively. nifedipine, with a pd'2 value of 6.88, was used as a known calcium antagonistic drug to compare the potency of the drugs studied. the relaxati ...19883234487
pharmacological activities of the prenylcoumarins, developed from folk usage as a medicine of peucedanum japonicum thunb.in connection with the chemical structure of coumarin 1 (a mixture of acetylangeloylkhellactone and acetyltigloylkhellactone), a compound isolated from peucedanum japonicum thunb., we synthesized eight coumarin compounds (3-10) and performed pharmacological studies on these nine compounds, as well as on another coumarin, praeruptorin a (= pd-ia) (2), a compound isolated from peucedanum praeruptorum dunn. we studied the effects of compounds 1-5 on isolated smooth muscle and of compounds 1-10 on t ...19911934161
[the chemical constituents of bai-hua-qian-hu, the root of peucedanum praeruptorum dunn. (umbelliferae)--four new coumarins (author's transl)]. 1979532649
effects of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin on myocardial dysfunction after a brief ischemia in anesthetized dogs.the effect of a 30-min infusion of 3'-angeloyloxy-4'-acetoxy-3', 4'-dihydroseselin (pd-ia), a coumarin isolated from peucedanum praeruptorum dunn 0.15 mg.kg-1.min-1 on regional myocardial dysfunction was examined in 16 anesthetized open-chest dogs subjected to a 15-min occlusion of the left anterior descending coronary artery followed by a 3-h reperfusion. segment lengths of left ventricular wall were measured with an ultrasonic micrometer. the control caused a decrease in the % of segment short ...19947717058
[chemical constituents from roots of peucedanum praeruptorum (v)].to study the chemical constituents in roots of peucedanum praeruptorum from henan.201223477142
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