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pleiotropic effects of the lpxm mutation in yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens.deletion mutants in the lpxm gene in two yersinia pestis strains, the live russian vaccine strain ev niieg and a fully virulent strain, 231, synthesise a less toxic penta-acylated lipopolysaccharide (lps). analysis of these mutants revealed they possessed marked reductions in expression and immunoreactivity of numerous major proteins and carbohydrate antigens, including f1, pla, ymt, v antigen, lps, and eca. moreover, both mutants demonstrated altered epitope specificities of the antigens as det ...200919428838
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