chronic opisthorchis felineus infection attenuates atherosclerosis--an autopsy study.previously, we proposed a hypothesis that chronic helminthic infection may have beneficial effects on the development of atherosclerosis. the aim of this study was to investigate an association between opisthorchis felineus chronic helminthic infections with aortic atherosclerosis and serum total cholesterol. a series of medico-legal autopsy specimens collected in khanty-mansiisk (the region in russia endemic for o. felineus) were studied to assess o. felineus worm burden in cadaver livers. the ...201323792298
validation of an excretory/secretory antigen based-elisa for the diagnosis of opisthorchis felineus infection in humans from low trematode endemic areas.since opisthorchiasis does not show pathognomonic signs or symptoms, physicians can have serious problems to make a differential diagnosis of this infection in non endemic areas, in particular when there is a simultaneous occurrence with other seasonal infections. moreover, symptomatic infections due to o. felineus can last a few weeks and then the signs and symptoms disappear, but the worms survive in the bile ducts for years causing hepatobiliary diseases including hepatomegaly, cholangitis, f ...201323671589
cryptic and asymptomatic opisthorchis felineus infections.we describe the diagnostic difficulties experienced during an opisthorchiasis outbreak. of 31 infected individuals, 61.3% were asymptomatic, and in the 12 symptomatic individuals, the duration of non-pathognomonic symptoms was shorter than 4 weeks. serology by enzyme-linked immunosorbent assay and polymerase chain reaction fecal analysis were shown to be the most sensitive diagnostic tools.201323249682
complete sequencing of the mitochondrial genome of opisthorchis felineus, causative agent of opisthorchiasis.opisthorchis felineus, a hepatic trematode, is the causative agent of opisthorchiasis, a dangerous disease in both human beings and animals. opisthorchiasis is widespread in russia, especially western siberia. the purpose of the present study was to determine the complete mitochondrial dna sequence of this flatworm. two parallel methods were employed: (1) capillary electrophoresis to sequence the mitochondrial genome fragments obtained through specific pcr amplification, and (2) high throughput ...200922649593
first report and molecular identification of opisthorchis viverrini infection in human communities from lower myanmar.opisthorchis viverrini is endemic in the south east asian region, especially in cambodia, lao people's democratic republic, vietnam and thailand, but there have been no previous records from myanmar. during stool surveys of rural populations in three regions of lower myanmar, opisthorchis-like eggs were found in 34 out of 364 (9.3%) participants by stool microscopy after using the modified formalin-ether concentration technique. dna was extracted from these positive stool samples and a portion o ...201728472153
abc transporters in the liver fluke opisthorchis felineus.atp-binding cassette transporters (abc transporters) are essential components of normal cellular physiological machinery in all eukaryotic and prokaryotic species, including parasites. some abc transporters, e.g., p-glycoproteins, are involved in the efflux of toxins and xenobiotics from the cell. at present, nothing is known about abc transporter genes in epidemiologically important liver flukes from the opisthorchiidae family, including european liver fluke opisthorchis felineus. opisthorchias ...201728729070
ultrastructural characters of the spermatozoon of the liver fluke opisthorchis viverrini (poirier, 1886) (opisthorchiidae).the present study records the ultrastructural organization of the mature spermatozoon of opisthorchis viverrini by means of transmission electron microscopy. the spermatozoon of o. viverrini is a filiform cell, tapered at both extremities. it exhibits the characteristics of type iv spermatozoon of digeneans, namely with two axonemes of the 9+'1' trepaxonematan pattern, external ornamentation of the plasma membrane associated with cortical microtubules that are in the posterior part of the anteri ...201728725936
magnetic resonance imaging and spectroscopy for differential assessment of liver abnormalities induced by opisthorchis felineus in an animal model.european liver fluke opisthorchis felineus, causing opisthorchiasis disease, is widespread in russia, ukraine, kazakhstan and sporadically detected in the eu countries. o. felineus infection leads to hepatobiliary pathological changes, cholangitis, fibrosis and, in severe cases, malignant transformation of bile ducts. due to absence of specific symptoms, the infection is frequently neglected for a long period. the association of opisthorchiasis with almost incurable bile duct cancer and rising i ...201728708894
anthelmintic activity of cytochrome p450 inhibitors miconazole and clotrimazole: in-vitro effect on the liver fluke opisthorchis felineus.discovery of drugs for the treatment of opisthorchiasis and schistosomiasis is a high priority. the basic metabolic cytochrome p450 (cyp) system in parasitic flatworms contains a single gene. cyp of the liver fluke opisthorchis felineus, the causative agent of opisthorchiasis, is important for survival of the worm, so it may be a promising target for therapeutics against liver fluke infection. the aims of this study were: (i) to analyse in-vitro anthelmintic activity of various cyp inhibitors us ...201728527633
secretion of thioredoxin peroxidase protein of cat liver fluke opisthorchis felineus during modeling of experimental opisthorchiasis.mechanisms of thioredoxin peroxidase secretion by opisthorchis felineus were studied in vivo and in vitro. specific antibodies were obtained and used for western blotting and immunohistochemical detection in syrian hamster model of opisthorchiasis. secreted thioredoxin peroxidase protein was accumulated in the worm incubation medium under conditions of oxidative stress and in bile duct cells of hamsters with chronic opisthorchiasis.201728429227
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