| curcumin blocks migration and invasion of mouse-rat hybrid retina ganglion cells (n18) through the inhibition of mmp-2, -9, fak, rho a and rock-1 gene expression. | cancer metastasis involves multiple processes which may complicate clinical management and even lead to death. matrix metalloproteinases (mmps) play an important role in cancer cell invasion, metastasis and angiogenesis, depending on whether agents can inhibit mmps which could lead to inhibition of the migration and invasion of cancer cells. curcumin, the active constituent of the dietary spice turmeric, has potential for the prevention and therapy of cancer. however, there is no study to addres ... | 2010 | 20127004 |
| curcumin upregulates insulin-like growth factor binding protein-5 (igfbp-5) and c/ebpalpha during oral cancer suppression. | curcumin is a common food ingredient derived from the plant curcuma longa and is a potent drug against tumorigenesis. both insulin-like growth factor binding protein-5 (igfbp-5) and ccaat/enhancer-binding protein alpha (c/ebpalpha) are suppressors of head and neck carcinogenesis. we identified curcumin as an inducer of igfbp-5 expression in multiple types of oral keratinocytes; furthermore, curcumin induces igfbp-5 promoter activity in sas oral cancer cells. promoter deletion mapping identified ... | 2010 | 20127863 |
| [preliminary effects of alcohol and curcuma longa upon cyp2e1 and hematotoxicity in benzene-induced mice]. | to observe the effects of cyp2e1 enzymatic alteration upon hematotoxicity by benzene poisoning in mice and the interference of alcohol and curcuma longa. | 2009 | 20137700 |
| inhibitory effects of curcumenol on human liver cytochrome p450 enzymes. | curcumenol, one of the major components of zedoary turmeric oil, has been widely used to treat cancer and inflammation. as an antibiotic or anticancer drug, curcumenol is highly likely to be used in combination with various synthetic drugs in most cases, thus it is necessary to evaluate potential pharmacokinetic drug-drug interactions induced by curcumenol. in this study, the inhibitory effects of curcumenol on seven cyp isoforms were investigated, and the results demonstrated that only cyp3a4 w ... | 2010 | 20148399 |
| curcumin: a novel nutritionally derived ligand of the vitamin d receptor with implications for colon cancer chemoprevention. | the nuclear vitamin d receptor (vdr) mediates the actions of 1,25-dihydroxyvitamin d(3) (1,25d) to regulate gene transcription. recently, the secondary bile acid, lithocholate (lca), was recognized as a novel vdr ligand. using reporter gene and mammalian two-hybrid systems, immunoblotting, competitive ligand displacement and quantitative real-time pcr, we identified curcumin (cm), a turmeric-derived bioactive polyphenol, as a likely additional novel ligand for vdr. cm (10(-5) m) activated transc ... | 2010 | 20153625 |
| curcumin inhibits gpvi-mediated platelet activation by interfering with the kinase activity of syk and the subsequent activation of plcgamma2. | turmeric (curcuma longa), a herbal remedy and culinary spice, has been used in traditional indian culture for millennia. an active ingredient found in turmeric is curcumin (diferuloylmethane). in the current study, we investigated the antiplatelet properties of this naturally occurring compound. curcumin inhibited human platelet aggregation and dense granule secretion induced by gpvi agonist convulxin in a concentration-dependent manner. at 50 microm, it effectively inhibited the maximal extent ... | 2010 | 20158382 |
| safety and toxicological evaluation of a novel anti-obesity formulation li85008f in animals. | li85008f is a novel synergistic composition of moringa oleifera, murraya koenigi, and curcuma longa. these herbs are well recognized and widely used in ayurvedic system of medicine for treating a variety of diseases and are also have been used for culinary purposes for thousands of years. li85008f inhibits preadipocyte differentiation and potentiates lipid breakdown in mature adipocytes. in diet-induced obese rats, li85008f significantly reduced weight gain and improved serum adiponectin levels. ... | 2010 | 20158386 |
| phytotherapy of ulcerative dermatitis induced by aeromonas hydrophila infection in goldfish ( carassius auratus ). | goldfish ( carassius auratus ) weighing 13 +/- 2 g were administered intramuscularly a sublethal dose (1.8 x 10 3 cfu/ml) of aeromonas hydrophila to induce ulcerative dermatitis. on day 3 and day 6 after infection the fish were dip-treated (for 5 min/day) with a tri-herbal concoction of curcuma longa, ocimum sanctum and azadirachta indica (1%). the ld 50 value was recorded at a concentration of 2.3 x 10 4 between 30 and 36 days after infection. in the infected untreated group the cumulative mort ... | 2010 | 20159736 |
| curcumin inhibits the growth, induces apoptosis and modulates the function of pituitary folliculostellate cells. | the polyphenol curcumin (diferuloylmethane) is the active componenet of the spice plant curcuma longa and has been shown to exert multiple actions on mammalian cells. we have studied its effect on folliculostellate (fs) ttt/gf mouse pituitary cells, representative of a multifunctional, endocrine inactive cell type of the anterior pituitary. proliferation of ttt/gf cells was inhibited by curcumin in a monolayer cell culture and in the colony formation assay in soft agar. fluorescence-activated ce ... | 2010 | 20160430 |
| anti-tumor activity of four ayurvedic herbs in dalton lymphoma ascites bearing mice and their short-term in vitro cytotoxicity on dla-cell-line. | the anti-tumor activity and chemopreventive potential of four ayurvedic herbs viz. curcuma longa l., ocimum sanctum l., tinospora cordifolia (wild) miers ex hook.f & thomas and zizyphus mauritiana lam. were evaluated using dalton lymphoma ascites (dla) tumor model in swiss albino mice. the outcome was assessed using survival time, peritoneal ascitic fluid (tumor volume) and hematological indices as parameters. animals were divided into five groups (n = 6) viz. one dla control and four herb + dla ... | 2008 | 20161965 |
| activation of muscarinic m-1 cholinoceptors by curcumin to increase contractility in urinary bladder isolated from wistar rats. | curcumin is an active principle contained in rhizome of curcuma longa, and it has been recently mentioned to show affinity to muscarinic m-1 cholinoceptors (m(1)-machr). in the present study, we found that curcumin caused a concentration-dependent increase of muscle tone in urinary bladder isolated from wistar rats. this action was inhibited by pirenzepine at concentration enough to block m(1)-machr. in radioligand-binding assay, specific binding of [(3)h]-oxotremorine (oxo-m) in the rat bladder ... | 2010 | 20172017 |
| curcumin attenuates inflammatory response in il-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. | curcumin, a major component of turmeric, has been shown to exhibit anti-oxidant and anti-inflammatory activities. the present study was performed to determine whether curcumin is efficacious against both collagen-induced arthritis (cia) in mice and il-1beta-induced activation in fibroblast-like synoviocytes (flss). dba/1 mice were immunized with bovine type ii collagen (cii) and treated with curcumin every other day for 2weeks after the initial immunization. for arthritis, we evaluated the incid ... | 2010 | 20188213 |
| curcumin: from food spice to cancer prevention. | curcumin [1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6 heptadiene-3, 5-dione] is an orange-yellow component of turmeric (curcuma longa), a spice often found in curry powder. it is known to have a variety of biologic and pharmacologic activities, including anti-inflammatory, anti-oxidant, and anticarcinogenic potential. it is a potent inhibitor of cytochrome p450 with capacity to simultaneously induce detoxifying enzymes such as glutathione s-transferase and as such may find application as a chemopr ... | 2009 | 20192567 |
| precursor-directed biosynthesis of curcumin analogs in escherichia coli. | curcuminoids, natural products in the rhizome of turmeric, show various biological activities, including antioxidant and antitumor activities. for this reason, curcuminoids have been focused on as potential pharmaceuticals. exogenous supplementation with various carboxylate precursors in genetically engineered escherichia coli cells carrying an artificially assembled pathway for curcuminoid biosynthesis led to the production of 17 unnatural curcuminoids. | 2010 | 20208337 |
| novel stat3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. | the constitutive activation of signal transducer and activator of transcription 3 (stat3) is frequently detected in most types of human cancer where it plays important roles in survival, drug resistance, angiogenesis, and other functions. targeting constitutive stat3 signaling is thus an attractive therapeutic approach for these cancers. we have recently developed novel small-molecule stat3 inhibitors, known as flll31 and flll32, which are derived from curcumin (the primary bioactive compound of ... | 2010 | 20215512 |
| ameliorative effects of curcumin on the seminiferous epithelium in metronidazole-treated mice: a stereological study. | metronidazole (mtz) has negative effects on sperm analysis and testis structure. curcumin is the principal curcuminoid found in turmeric and exhibits antitumor, anti-inflammatory, and anti-infectious activities with low toxicity. to evaluate stereological changes of seminiferous germinal epithelium by mtz and ameliorative effects of curcumin, balb-c mice were divided into 6 groups. the control, second, third, fourth, fifth, and sixth groups were administrated distilled water, high doses of mtz ( ... | 2010 | 20215582 |
| the influence of the long-term administration of curcuma longa extract on learning and spatial memory as well as the concentration of brain neurotransmitters and level of plasma corticosterone in aged rats. | the effects of chronic pre-treatment with a standardised extract of curcuma longa on learning and spatial memory in aged 24-month old male wistar rats were estimated in a morris water maze paradigm. animals received the extract orally for two months in prepared rodent chow to obtain the doses 10 and 50mg/kg/day. at the end of behavioural trials the concentration of neurotransmitters, their metabolites and amino acids in selected brain regions were estimated. there was a significant decrease in e ... | 2010 | 20219527 |
| curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo. | trivalent arsenic [as(iii)] is currently approved by the fda for the treatment of chronic and acute leukemias. however, as(iii) has also demonstrated damaging effects on human health, including development of cardiovascular disease, diabetes, and cancer. further, as(iii) is a potent angiogenic agent. in this context, curcumin, an active ingredient in the dietary agent turmeric, has demonstrated potent antiproliferative, antiinflammatory, and antiangiogenic properties. in this report, we have sho ... | 2010 | 20232614 |
| antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. | to review efficacy studies of antioxidant and antiinflammatory dietary supplements used to manage osteoarthritis (oa) and rheumatoid arthritis (ra) and make conclusions about their place in therapy. glucosamine, chondroitin, and methyl sulfonyl methane were excluded. | 2010 | 20232616 |
| curcumin improves sclerosing cholangitis in mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation. | chronic cholangiopathies have limited therapeutic options and represent an important indication for liver transplantation. curcumin, the yellow pigment of the spice turmeric, has pleiotropic actions and attenuates hepatic damage in animal models of chemically-induced liver injury. whether curcumin has beneficial effects in cholangiopathies is unknown. | 2010 | 20332524 |
| curcumin dramatically enhances retinoic acid-induced superoxide generating activity via accumulation of p47-phox and p67-phox proteins in u937 cells. | the membrane bound cytochrome b558 composed of large gp91-phox and small p22-phox subunits, and cytosolic proteins p40-, p47- and p67-phox are important components of superoxide (o(2)(-))-generating system in phagocytes and b lymphocytes. a lack of this system in phagocytes is known to cause serious life-threatening infections. here, we describe that curcumin, a polyphenol responsible for the yellow color of curry spice turmeric, dramatically activates the o(2)(-)-generating system during retino ... | 2010 | 20346917 |
| purification and properties of cysteine protease from rhizomes of curcuma longa (linn.). | turmeric rhizome (curcuma domestica linn.) contains proteases and has proteolytic activity. curcumin from turmeric rhizomes has been used for healing many ailments, including cancer. the purpose of this study was to purify turmeric protease and to research their biochemical characteristics [corrected]. | 2010 | 20355018 |
| curcumin-induced suppression of adipogenic differentiation is accompanied by activation of wnt/beta-catenin signaling. | curcumin, a polyphenol found in the rhizomes of curcuma longa, improves obesity-associated inflammation and diabetes in obese mice. curcumin also suppresses adipocyte differentiation, although the underlying mechanism remains unclear. here, we used 3t3-l1 cells to investigate the details of the mechanism underlying the anti-adipogenic effects of curcumin. curcumin inhibited mitogen-activated protein kinase (mapk) (erk, jnk, and p38) phosphorylation that was associated with differentiation of 3t3 ... | 2010 | 20357182 |
| perspectives on chemopreventive and therapeutic potential of curcumin analogs in medicinal chemistry. | curcumin is a natural polyphenol derived from the plant curcuma longa, commonly called turmeric. extensive research over past 50 years has indicated that this polyphenol is highly pleiotropic molecule capable of preventing and treating various cancers. the anticancer potential of curcumin is severely affected by its limited systemic and target tissue bioavailability and rapid metabolism. in the present review article, we provide a summarized account of different drug delivery systems employed fo ... | 2010 | 20370702 |
| monoacetylcurcumin strongly regulates inflammatory responses through inhibition of nf-kappab activation. | curcumin, a component of turmeric (curcuma longa), is known to exert a variety of biological functions including anti-inflammatory activity. we examined the inhibitory effects of chemically synthesized derivatives of curcumin against inflammatory responses and compared them with those of curcumin, in order to find derivatives with stronger effects than curcumin. in a cell culture system using the mouse macrophage cell line raw264.7, monoacetylcurcumin strongly inhibited ikappab phosphorylation, ... | 2010 | 20372820 |
| curcumin induces down-regulation of ezh2 expression through the mapk pathway in mda-mb-435 human breast cancer cells. | curcumin, a natural compound isolated from turmeric, may inhibit cell proliferation in various tumor cells through a mechanism that is not fully understood. the enhancer of zeste homolog 2 (ezh2) gene is overexpressed in human breast cancers with poor prognosis. in this study, we observed a dose- and time-dependent down-regulation of expression of ezh2 by curcumin that correlates with decreased proliferation in the mda-mb-435 breast cancer cell line. the curcumin treatment resulted in an accumul ... | 2010 | 20385124 |
| curcumin inhibits cholesterol uptake in caco-2 cells by down-regulation of npc1l1 expression. | curcumin is a polyphenol and the one of the principle curcuminoids of the spice turmeric. its antioxidant, anti-cancer and anti-inflammatory effects have been intensively studied. previous in vivo studies showed that administration of curcumin also decreased cholesterol levels in the blood, and the effects were considered to be related to upregulation of ldl receptor. however, since plasma cholesterol levels are also influenced by the uptake of cholesterol in the gut, which is mediated by a spec ... | 2010 | 20403165 |
| ppargamma agonist curcumin reduces the amyloid-beta-stimulated inflammatory responses in primary astrocytes. | alzheimer's disease (ad) is the most common age-related neurodegenerative disorder. accumulating data indicate that astrocytes play an important role in the neuroinflammation related to the pathogenesis of ad. it has been shown that microglia and astrocytes are activated in ad brain and amyloid-beta (abeta) can increase the expression of cyclooxygenase 2 (cox-2), interleukin-1, and interleukin-6. suppressing the inflammatory response caused by activated astrocytes may help to inhibit the develop ... | 2010 | 20413894 |
| a validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection. | curcumin, a lipophilic polyphenol derived from the rhizome of the plant turmeric (curcuma longa), might be useful in the prevention and treatment of a number of degenerative brain disorders, including glioma multiforma and alzheimer's disease. thus, there is growing interest in measuring curcumin concentrations in the brain and other target tissues in relevant animal models. we therefore developed and validated (according to the food and drug administration guidelines for bioanalytical method va ... | 2010 | 20419505 |
| targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. | extensive research within the past two decades has revealed that obesity, a major risk factor for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a proinflammatory disease. several spices have been shown to exhibit activity against obesity through antioxidant and anti-inflammatory mechanisms. among them, curcumin, a yellow pigment derived from the spice turmeric (an essential component of curry powder), has been investigated most extensively as a treatment for obesity an ... | 2010 | 20420526 |
| oral dose-ranging developmental toxicity study of an herbal supplement (nt) and gallic acid in rats. | to evaluate the combination of rhubarb, astragalus, red sage, ginger, and turmeric (mixture referred to as "nt") together with gallic acid for evidence of reproductive toxicity in rats. | 2010 | 20422471 |
| inhibitory effect of encapsulated curcumin on ultraviolet-induced photoaging in mice. | photoaging is the superposition of photodamage (ultraviolet [uv] radiation-induced) on the aging process. it is a major damaging consequence of free radical action. curcumin (diferuloylmethane) is a phytochemical with diverse antioxidant and antiinflammatory properties. however, it shows a poor topical bioavailability. therefore, we encapsulated curcumin in elastic vesicles (evs) and investigated different doses (1, 3, 5 and 10 micromol) for its in vivo antiaging activity in mice. vicco turmeric ... | 2010 | 20426620 |
| potentiation of gemcitabine by turmeric force in pancreatic cancer cell lines. | gemcitabine is a first line cancer drug widely used for the treatment of pancreatic cancer. however, its therapeutic efficiency is significantly limited by resistance of pancreatic cancer cells to this and other chemotherapeutic drugs. we have investigated the cytotoxic effect of turmeric force (tf), a supercritical and hydroethanolic extract of turmeric, alone and in combination with gemcitabine in two pancreatic carcinoma cell lines (bxpc3 and panc-1). tf is highly cytotoxic to bxpc3 and panc- ... | 2010 | 20428806 |
| evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from curcuma longa. | the rhizome of curcuma longa (cl) has been commonly used in asia as a potential candidate for the treatment of different diseases, including inflammatory disorders and cancers. the present study evaluated the anti-proliferative activities of the isolated compounds (three curcuminoids and two turmerones) from cl, using human cancer cell lines hepg2, mcf-7 and mda-mb-231. the immunomodulatory activities of turmerones (alpha and aromatic) isolated from cl were also examined using human peripheral b ... | 2010 | 20438793 |
| investigation of the anti-inflammatory effect of curcuma longa in helicobacter pylori-infected patients. | helicobacter pylori infection of the lining of the stomach induces an array of inflammatory cytokine production leading to gastritis and peptic ulcer disease. the aim of this study was to investigate the effect of curcumin on the production of interleukin (il)-8, il-1beta, tumor necrosis factor (tnf)-alpha and cyclooxygenase (cox)-2 in gastric mucosa from h. pylori-infected gastritis patients. patients were randomly assigned to receive either oam (omeprazole, amoxicillin and metronidazole) treat ... | 2010 | 20438867 |
| in vitro effects of plant and mushroom extracts on immunological function of chicken lymphocytes and macrophages. | 1. the present study was conducted to examine the effects of organic extracts from milk thistle (silybum marianum), turmeric (curcuma longa), reishi mushroom (ganoderma lucidum), and shiitake mushroom (lentinus edodes) on innate immunity and tumor cell viability. 2. innate immunity was measured by lymphocyte proliferation and nitric oxide production by macrophages, and the inhibitory effect on tumor cell growth was assessed using a non-radioactive assay. for measuring the cytokine levels in the ... | 2010 | 20461582 |
| plant polyphenol curcumin significantly affects cyp1a2 and cyp2a6 activity in healthy, male chinese volunteers. | curcumin is a kind of plant polyphenol that is extracted from the rhizome of curcuma longa. studies about the effect of curcumin on the activity of drug-metabolizing enzymes in humans are lacking. | 2010 | 20484172 |
| increase in plasma concentrations of geranylgeranoic acid after turmeric tablet intake by healthy volunteers. | geranylgeranoic acid (gga) is one of the most potent cancer-preventive acyclic retinoids. gga has been shown to induce cell death in human hepatoma-derived huh-7 cells. we have recently reported the natural occurrence of gga and its related compounds in several medicinal herbs such as turmeric, basil, rosehip, cinnamon and others [shidoji and ogawa, j. lipid res., 45: 1092-1103, 2004]. in the present study, we performed oral administration of turmeric tablets to healthy volunteers in order to in ... | 2010 | 20490321 |
| effects of curcuma extracts and curcuminoids on expression of p-glycoprotein and cytochrome p450 3a4 in the intestinal cell culture model ls180. | curcuma longa l. is a widely used spice. its main ingredients, the curcuminoids, are used in the treatment of inflammatory diseases and cancer. bioavailability of curcuminoids is low, and huge amounts remain in the intestine. we therefore aimed to investigate their interaction potential with the abc-transporter p-glycoprotein (p-gp, product of the mdr1/abcb1 gene) and cytochrome p450 3a4 (cyp3a4) in an intestinal cell line (ls180). intestinal p-gp and cyp3a4 play a major role in drug absorption, ... | 2010 | 20509107 |
| curcumin modulates dopaminergic receptor, creb and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats. | curcumin, an active principle component in rhizome of curcuma longa, has proved its merit for diabetes through its anti-oxidative and anti-inflammatory properties. this study aims at evaluating the effect of curcumin in modulating the altered dopaminergic receptors, creb and phospholipase c in the cerebral cortex and cerebellum of stz induced diabetic rats. radioreceptor binding assays and gene expression was done in the cerebral cortex and cerebellum of male wistar rats using specific ligands a ... | 2010 | 20513244 |
| tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. | curcumin, capsaicin and piperine--the bioactive compounds present in spices--turmeric (curcuma longa), red pepper (capsicum annuum) and black pepper (piper nigrum) respectively, have a considerable portion of structural homology. tissue distribution and elimination of these three structurally similar bioactive compounds was examined following their oral intake in rats. | 2010 | 20516541 |
| effect of a novel antiinflammatory polyherbal preparation (sudarshanam oil) on hematological parameters in wistar rats. | the present investigation was an attempt to evaluate the anti-inflammatory effect of a polyherbal preparation (sudarshanam oil) on hematological parameters in wistar rats. this polyherbal formula contains main ingredients of tinaspora cordifolia, curcuma longa, terminalia chebula, emblica officinalis, andrographis paniculata and terminalia belerica. the active phytochemicals such as tannins, glycosides, flavonoids and triterpenoids are extracted from these herbal plants. and extract was prepared ... | 2010 | 20524430 |
| curcumin inhibits reactive oxygen species formation and vascular hyperpermeability following haemorrhagic shock. | 1. oxidative stress induced by reactive oxygen species (ros) is a key mediator of haemorrhagic shock (hs)-induced vascular hyperpermeability. in the present study, curcumin, a natural anti-oxidant obtained from turmeric (curcuma longa), was tested against hs-induced hyperpermeability and associated ros formation in rat mesenteric post-capillary venules in vivo and in rat lung microvascular endothelial cells (rlmec) in vitro. 2. in rats, hs was induced by withdrawing blood to reduce mean arterial ... | 2010 | 20528978 |
| curcumin improves early functional results after experimental spinal cord injury. | curcumin is a polyphenol extracted from the rhizome of curcuma longa and well known as a multifunctional drug with anti-oxidative, anticancerous, and anti-inflammatory activities. the aim of the study was to evaluate and compare the effects of the use of the curcumin and the methylprednisolone sodium succinate (mpss) functionally, biochemically, and pathologically after experimental spinal cord injury (sci). | 2010 | 20535508 |
| curcuminoids enhance memory in an amyloid-infused rat model of alzheimer's disease. | alzheimer's disease (ad) is a neurodegenerative disease. there are a limited number of therapeutic options available for the treatment of ad. curcuminoids (a mixture of bisdemethoxycurcumin, demethoxycurcumin and curcumin) is the main chemical constituent found in turmeric, a well known curry spice, having potential in the treatment of ad. the objective of this study was to investigate the effects of curcuminoid mixture and individual constituents on spatial learning and memory in an amyloid-bet ... | 2010 | 20538041 |
| immobilization of silver nanoparticles synthesized using curcuma longa tuber powder and extract on cotton cloth for bactericidal activity. | the present study reports the synthesis of silver (ag) nanoparticles from silver precursor using plant biomaterials, curcuma longa tuber powder and extract. water-soluble organics present in the plant materials were mainly responsible for the reduction of silver ions to nano-sized silver particles. ph played a major role in size control of the particles. silver nanoparticle synthesis was higher in tuber extract compared to powder, which was attributed to the large and easy availability of the re ... | 2010 | 20541399 |
| synergistic effect of curcumin and insulin on muscle cell glucose metabolism. | curcumin is a major phenolic compound of curcuma longa, which has long been used in traditional indian medicine. recently, curcumin has been reported to have antihyperglycemic activity in animal models. however, the molecular basis of this action has not been adequately described. in the present study, curcumin was observed to contain a high level of polyphenols and strong antioxidant activity. then, the antihyperglycemic effect of curcumin was examined for various signaling pathways using c(2)c ... | 2010 | 20561944 |
| effect of curcumin on pathogenesis of hamster-opisthorchiasis through apoptosis-related gene expression. | the present study investigated the effect of curcumin, a phenolic compound with yellow color from curcuma longa l., on the expression of the apoptosis-related genes [bax (bcl-2 associated protein x), pkb, p53, mdm2 (mouse double minute 2), caspase 9, c-ski, smad1 and smad4] in hamster opisthorchiasis. on opisthorchis viverrini infection treated with dietary curcumin apoptosis-related gene expression profiles were similar to o. viverrini-infected group, but the expression levels seemed lower. lig ... | 2009 | 20578454 |
| curcumin decreases toll-like receptor-2 gene expression and function in human monocytes and neutrophils. | toll-like receptor-2 (tlr2) is a pattern recognition receptor that senses many types of bacterial components and activates signaling pathways that induce inflammatory cytokines. a hyperresponsiveness to pathogens caused by increased expression of tlr2 triggers exaggeration of some inflammatory diseases. here, we showed that curcumin, a well-known anti-inflammatory agent derived from the curry spice turmeric, inhibits tlr2 expression in various tlr2-expressing innate immune cell lines such as mon ... | 2010 | 20599422 |
| curcumin prevents cardiac remodeling secondary to chronic renal failure through deactivation of hypertrophic signaling in rats. | the prevalence of left ventricular hypertrophy (lvh) is frequent in patients with end-stage renal disease following chronic renal failure (crf). we investigated the therapeutic efficacy of curcumin, the principal curcuminoid of the indian curry spice turmeric, in attenuation of lvh and sought to delineate the associated signaling pathways in blunting the hypertrophic response in nephrectomized rats. adult sprague-dawley rats underwent nephrectomy (nx) by removal of 5/6 of the kidneys. four group ... | 2010 | 20601462 |
| new role of (-)-epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin. | curcumin, a phenolic compound isolated from the plant curcuma longa (linn), is ingested every day in the indian subcontinent and is well reported to possess cancer-preventive activity. to achieve effective cancer prevention with curcumin, we need to find a new method to enhance the effects of curcumin in the diet. based on our evidence that (-)-epicatechin (ec), an inert catechin, enhances the cancer-preventive activity of green tea catechins, we studied the enhancing effects of ec on inductions ... | 2010 | 20606042 |
| hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet. | there is an increasing interest in curcumin (curcuma longa l.) as a cardiovascular disease (cvd) protective agent via decreased blood total cholesterol and low-density lipoprotein-cholesterol (ldl-cholesterol) level. the aim of this study was to investigate further the potential mechanism in the hypocholesterolemic effect of curcumin by measuring cholesterol 7a-hydroxylase (cyp7a1), a rate limiting enzyme in the biosynthesis of bile acid from cholesterol, at the mrna level. male sprague-dawley r ... | 2010 | 20607063 |
| immunostimulatory activities of polysaccharide extract isolated from curcuma longa. | several curcuminoids and sesquiterpenoids isolated from curcuma longa (cl) have been shown to have many pharmacological activities. in the present study, the immunomodulatory activities of the polar fractions of cl hot water extracts were investigated using human peripheral blood mononuclear cells (pbmc). our results showed that the high polarity fraction of the hot water extract exhibited stimulatory effects on pbmc proliferation as shown in [methyl-(3)h]-thymidine incorporation assay. in an at ... | 2010 | 20609432 |
| probing the binding site of curcumin in escherichia coli and bacillus subtilis ftsz--a structural insight to unveil antibacterial activity of curcumin. | the cytoskeletal protein, ftsz plays a pivotal role in prokaryotic cell division and is present in majority of the bacterial species. in recent years, inhibitors of ftsz have been identified that may function as lead compounds for the development of novel antimicrobials. it has been found that curcumin, the main bioactive component of curcuma longa, inhibits bacillus subtilis and escherichia coli growth by inhibiting ftsz assembly. though it is experimentally established that curcumin inhibits f ... | 2010 | 20615583 |
| curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. | alzheimer disease (ad) is a devastating neurodegenerative disease with no cure. the pathogenesis of ad is believed to be driven primarily by amyloid-beta (abeta), the principal component of senile plaques. abeta is an approximately 4-kda peptide generated via cleavage of the amyloid-beta precursor protein (app). curcumin is a compound in the widely used culinary spice, turmeric, which possesses potent and broad biological activities, including anti-inflammatory and antioxidant activities, chemop ... | 2010 | 20622013 |
| curcumin promotes apoptosis in a549/ddp multidrug-resistant human lung adenocarcinoma cells through an mirna signaling pathway. | curcumin extracted from the rhizomes of curcuma longa l. has been shown to have inhibitory effects on cancers through its anti-proliferative and pro-apoptotic activities. emerging evidence demonstrates that curcumin can overcome drug resistance to classical chemotherapies. thus, the mechanisms underlying the anti-tumor activities of curcumin require further study. in our study, we first demonstrated that curcumin had anti-cancer effects on a549/ddp multidrug-resistant human lung adenocarcinoma c ... | 2010 | 20627087 |
| gabaergic and nitriergic modulation by curcumin for its antianxiety-like activity in mice. | in the present study, effect of curcumin (10 and 20mg/kg), an active constituent of curcuma longa was evaluated for its antianxiety-like activity in mice subjected to immobilization-induced restraint stress for 6h. the effect on anxiety was assessed by employing elevated plus maze, open field test, light/dark test and social interaction test. only the higher dose (20mg/kg, i.p.) of curcumin produced significant antianxiety-like effect in stressed mice. pre-treatment with aminoguanidine (50mg/kg; ... | 2010 | 20633542 |
| curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through nf-kappab inhibition. | ethnopharmacological relevance: curcumin, a polyphenol compound from curcuma longa l. has been used for centuries as an anti-inflammatory remedy including asthma. curcumin has been reported to exert an anti-inflammatory effect, in part, through inhibition of the nf-kappab pathway. aim of the study: the purposes of this study were to determine whether curcumin inhibits nf-kappab-dependent transcription in vitro, and test whether treatment with curcumin reduces allergen-induced airway inflammation ... | 2010 | 20643202 |
| systemic administration of polymeric nanoparticle-encapsulated curcumin (nanocurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. | curcumin or diferuloylmethane is a yellow polyphenol extracted from the rhizome of turmeric (curcuma longa). a large volume (several hundreds) of published reports has established the anticancer and chemopreventative properties of curcumin in preclinical models of every known major cancer type. nevertheless, the clinical translation of curcumin has been significantly hampered due to its poor systemic bioavailability, which mandates that patients consume up to 8 to 10 g of the free drug orally ea ... | 2010 | 20647339 |
| epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin. | diabetes is a proinflammatory state. we have previously shown increased monocyte proinflammatory cytokines in patients with type 1 and type 2 diabetes. high glucose induces proinflammatory cytokines via epigenetic changes. curcumin, a polyphenol responsible for the yellow color of the spice turmeric, is known to exert potent anti-inflammatory activity in vitro. recent studies indicate that it may regulate chromatin remodeling by inhibiting histone acetylation. in this study, we aimed to test the ... | 2011 | 20655188 |
| curcumin protects hepatic stellate cells against leptin-induced activation in vitro by accumulating intracellular lipids. | obesity and type ii diabetes mellitus are often associated with hyperleptinemia and commonly accompanied by nonalcoholic steatohepatitis, which could cause hepatic fibrosis. during hepatic fibrogenesis, the major effectors hepatic stellate cells (hscs) become active, coupling with depletion of cellular lipid droplets and downexpression of genes relevant to lipid accumulation. accumulating evidence supports the proposal that recovering the accumulation of lipids would inhibit hsc activation. we r ... | 2010 | 20660066 |
| the inhibitory effect of turmeric curcuminoids on matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells. | matrix metalloproteinase-3 (mmp-3) is a key enzyme with important implications in the invasion and metastasis of breast cancer cells. curcumin (cur), demethoxycurcumin (dmc), and bisdemethoxycurcumin (bdmc) are major forms of curcuminoids found in turmeric powder with reported anticancer activity. this study focuses on the comparative effect of cur, dmc and bdmc on the modulation of mmp-3 activity and its secretion in mda-mb-231 breast cancer cells. mmp-3 levels were determined by casein zymogra ... | 2010 | 20661707 |
| toxicity prediction of compounds from turmeric (curcuma longa l). | turmeric belongs to the ginger family zingiberaceae. currently, cheminformatics approaches are not employed in any of the spices to study the medicinal properties traditionally attributed to them. the aim of this study is to find the most efficacious molecule which does not have any toxic effects. in the present study, toxicity of 200 chemical compounds from turmeric were predicted (includes bacterial mutagenicity, rodent carcinogenicity and human hepatotoxicity). the study shows out of 200 comp ... | 2010 | 20667459 |
| inhibitory effect of curcumin on uterine leiomyoma cell proliferation. | objective. uterine leiomyomas are the most common gynaecological benign tumour and greatly affect reproductive health and wellbeing. they are the predominant indication for hysterectomy in premenopausal women. curcumin, a well-known component of turmeric, has been reported to prevent various diseases such as cancer, diabetes and obesity. previous study reported that curcumin represses the proliferation of several tumour cells. however, there has not been a precise characterisation of the curcumi ... | 2010 | 20672906 |
| cell proliferative effect of polyxyloses extracted from the rhizomes of wild turmeric, curcuma aromatica. | hot water-soluble crude polysaccharides were extracted from the rhizomes of wild turmeric, curcuma aromatica salisb. (zingiberaceae), using dry grinding, boiling water extraction, and then ethanol precipitation. the crude polysaccharide extract was then fractionated by deae-cellulose ion exchange column chromatography, and subsequently further purified by superdex g-200 gel filtration column chromatography, giving two relatively abundant polysaccharide fractions, called p11 and p21, and a much l ... | 2010 | 20673181 |
| dietary supplementation with a probiotic fermented four-herb combination enhances immune activity in broiler chicks and increases survivability against salmonella gallinarum in experimentally infected broiler chicks. | herbs including curcuma longa, houttuynia cordata, prunus mume and rubus coreanus have potential immune enhancing and antimicrobial effects. probiotics also have antibacterial effects, and some are important in regulating the immune system. the aims of the present study were to evaluate the immune enhancing effects of a probiotic fermented four-herb combination (pfh) in broiler chicks and to demonstrate the prophylactic effect of pfh against salmonella gallinarum in experimentally infected broil ... | 2010 | 20675965 |
| [curcumin promoted the apoptosis of cisplain-resistant human lung carcinoma cells a549/ddp through down-regulating mir-186*]. | curcumin, a natural compound, is derived from the rthizom of curcuma longa. in vitro and in vivo preclinical studies have shown its anti-inflammatory, antioxidant, anticancer activities and so on. mir-186*, which was found by microarray technology, was highly expressed in lung carcinoma cells a549/ddp. the aim of this study is to illustrate whether curcumin could promote the apoptosis of a549/ddp cells through regulating the expression of mir-186*. | 2010 | 20677554 |
| apoptosis of human lung cancer cells by curcumin mediated through up-regulation of "growth arrest and dna damage inducible genes 45 and 153". | the expression of "growth arrest and dna damage inducible genes 45 and 153" is related to apoptotic induction of cells. gadd45 is an effector gene of the tumor suppressor p53, and gadd153 is associated with cellular function of cancer prevention. curcumin, isolated from the plant curcuma longa (linn), has been investigated as a promising cancer preventive in food because curcumin, a phenolic and coloring compound, is widely ingested in the indian subcontinent. however, the exact mechanisms of ac ... | 2010 | 20686221 |
| curcumin modulates leukocyte and platelet adhesion in murine sepsis. | circulating cell-endothelial cell interaction in sepsis is a rate-determining factor in organ dysfunction, and interventions targeting this process have a potential therapeutic value. in this project, we examined whether curcumin, an active ingredient of turmeric and an anti-inflammatory agent, could disrupt interactions between circulating blood cells and endothelium and improve survival in a murine model of sepsis. | 2010 | 20690979 |
| isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity. | curcumin (1), demethoxycurcumin (2) and bisdemethoxycurcumin (3), the curcuminoid constituents of the medicinal plant curcuma longa l., have been structurally modified to 55 analogs and antimycobacterial activity against mycobacterium tuberculosis has been evaluated. among the highly active curcuminoids, the isoxazole analogs are the most active group, with mono-o-methylcurcumin isoxazole (53) being the most active compound (mic 0.09 microg/ml). it was 1131-fold more active than curcumin (1), th ... | 2010 | 20691508 |
| multiple anticancer activities of ef24, a novel curcumin analog, on human ovarian carcinoma cells. | curcumin, a component of turmeric, has been reported to exhibit potential antitumor activities. this study assessed the effects of a novel synthetic curcumin analog, ef24, on proliferation, apoptosis, and vascular endothelial growth factor (vegf) regulation in platinum-sensitive (igrov1) and platinum-resistant (sk-ov-3) human ovarian cancer cells. ef24 time- and dose-dependently suppressed the growth of both cell lines and synergized with cisplatin to induce apoptosis. although treatment with ef ... | 2010 | 20693500 |
| in vitro biological evaluation of electrospun cellulose acetate fiber mats containing asiaticoside or curcumin. | ultra-fine cellulose acetate (ca; m(w) approximately 30,000 da; degree of acetyl substitution approximately 2.4) fiber mats containing either asiaticoside [from the plant centella asiatica (l.); either in the form of a crude extract (cace) or pure substance (pac)] or curcumin (cm; from the plant curcuma longa l.) were successfully prepared. the proposed use of these materials is as topical/transdermal patches or wound dressings. here, the potential for use of these herb-loaded ca fiber mats as w ... | 2010 | 20694988 |
| protection of trabecular bone in ovariectomized rats by turmeric (curcuma longa l.) is dependent on extract composition. | extracts prepared from turmeric (curcuma longa l., [zingiberaceae]) containing bioactive phenolic curcuminoids were evaluated for bone-protective effects in a hypogonadal rat model of postmenopausal osteoporosis. three-month female sprague-dawley rats were ovariectomized (ovx) and treated with a chemically complex turmeric fraction (41% curcuminoids by weight) or a curcuminoid-enriched turmeric fraction (94% curcuminoids by weight), both dosed at 60 mg/kg 3x per week, or vehicle alone. effects o ... | 2010 | 20695490 |
| curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials. | curcumin (diferuloylmethane), a derivative of turmeric is one of the most commonly used and highly researched phytochemicals. abundant sources provide interesting insights into the multiple mechanisms by which curcumin may mediate chemotherapy and chemopreventive effects on cancer. the pleiotropic role of this dietary compound includes the inhibition of several cell signaling pathways at multiple levels, such as transcription factors (nf-κb and ap-1), enzymes (cox-2, mmps), cell cycle arrest (cy ... | 2010 | 20726007 |
| enhanced oral bioavailability of docetaxel in rats by four consecutive days of pre-treatment with curcumin. | as with many other anti-cancer agents, docetaxel is a substrate for atp-binding cassette transporters such as p-glycoprotein and its metabolism is mainly catalysed by cyp3a. in order to improve the oral bioavailability of docetaxel, a component of turmeric, curcumin, which can down-regulate the intestinal p-glycoprotein and cyp3a protein levels, was used for the pre-treatment of rats before the oral administration of docetaxel. curcumin (100 mg/kg) did not significantly modify the pharmacokineti ... | 2010 | 20727390 |
| an aqueous extract of curcuma longa (turmeric) rhizomes stimulates insulin release and mimics insulin action on tissues involved in glucose homeostasis in vitro. | curcuma longa (turmeric) has been used widely as a spice, particularly in asian countries. it is also used in the ayurvedic system of medicine as an antiinflammatory and antimicrobial agent and for numerous other curative properties. the aim of this study was to investigate the effects of an aqueous extract of curcuma longa (aec) on tissues involved in glucose homeostasis. the extract was prepared by soaking 100 g of ground turmeric in 1 l of water, which was filtered and stored at -20°c prior t ... | 2011 | 20734343 |
| anti-breast cancer activity of curcumin on the human oxidation-resistant cells zr-75-1 with gamma-glutamyltranspeptidase inhibition. | since curcumin, a polyphenol extracted from the rhizomes of curcuma longa l. (zingiberaceae), has been proposed for breast cancer chemoprevention, the aim of the present work was to determine if it had anti-tumour effects on mammary cells which are resistant to oxidative damage. zr-75-1 cells were treated with curcumin and copper(ii) sulphate in order to evaluate cell death and gamma-glutamyltranspeptidase (ggtp) activity. curcumin was cytotoxic in a dose-dependent manner (loss of viability with ... | 2010 | 20734924 |
| cellular uptake, retention and bioabsorption of ho-3867, a fluorinated curcumin analog with potential antitumor properties. | curcumin, a naturally-occurring compound found in the rhizome of curcuma longa plant, is known for its antitumor activities. however, its clinical efficacy is limited due to poor bioabsorption. a new class of synthetic analogs of curcumin, namely diarylidenylpiperidone (dap), has been developed with substantially higher anticancer activity than curcumin. however, its cellular uptake and bioabsorption have not been evaluated. in this study we have determined the absorption of a representative dap ... | 2010 | 20798598 |
| evaluation of curcumin acetates and amino acid conjugates as proteasome inhibitors. | curcumin (diferuloylmethane) is the main active ingredient of turmeric, a traditional herbal medicine and food of south asia. curcumin has been found to have a wide range of biological activities, including antioxidant, anti-inflammatory, chemopreventive and chemotherapeutic activities. curcumin is currently being tested in clinical trials for treatment of various types of cancers, including multiple myeloma, pancreatic cancer and colon cancer. although no toxicity associated with curcumin (even ... | 2010 | 20818481 |
| indirect effect of a turmeric diet: enhanced bile duct proliferation in syrian hamsters with a combination of partial obstruction by opisthorchis viverrini infection and inflammation by n-nitrosodimethylamine administration. | the present study revealed the indirect effect of a turmeric (tur) diet on the histopathological changes and proliferating cell nuclear antigen staining in syrian hamsters with partial obstruction by liver fluke (opisthorchis viverrini) infection and inflammation by n-nitrosodimethylamine (ndma) administration. the result of the analysis of histopathological changes shows that a tur diet has an anti-inflammatory property in the case of a single condition of ndma administration or o. viverrini in ... | 2011 | 20821233 |
| curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis. | cholangiocarcinoma (cca) is a highly metastatic tumor linked to liver fluke infection and consumption of nitrosamine-contaminated foods and is a major health problem especially in south-eastern asia. in search for a suitable chemopreventive agents, we investigated the effect of curcumin, a traditional anti-inflammatory agent derived from turmeric (curcuma longa), on cca development in an animal model by infection with the liver fluke opisthorchis viverrini and administration of n-nitrosodimethyl ... | 2011 | 20824699 |
| photokilling of bacteria by curcumin in selected polyethylene glycol 400 (peg 400) preparations. studies on curcumin and curcuminoids, xli. | curcumin, bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, is a yellow-orange pigment which can be synthesised chemically or isolated from the plant curcuma longa l. curcumin has a rather broad absorption peak in the range 300-500 nm (maximum approximately 430 nm) and has potential as a photosensitiser for treatment of localised superficial infections in e.g., the mouth or skin. previously, we have demonstrated phototoxic effects of curcumin in selected aqueous preparations against both ... | 2010 | 20824961 |
| coffee, broccoli and spices are strong inducers of electrophile response element-dependent transcription in vitro and in vivo - studies in electrophile response element transgenic mice. | cytoprotective gene products, e.g. phase ii - and antioxidant enzymes, are important in cellular redox homeostasis. a common feature of these genes is binding sites for transcription factor nuclear factor erythroid-2-related factor 2 (nrf2), named electrophile response elements (epres) within their promoters. | 2011 | 20827676 |
| the genome-wide expression profile of curcuma longa-treated cisplatin-stimulated hek293 cells. | the rhizome of turmeric, curcuma longa (cl), is a herbal medicine used in many traditional prescriptions. it has previously been shown that cl treatment showed greater than 47% recovery from cisplatin-induced cell damage in human kidney hek 293 cells. this study was conducted to evaluate the recovery mechanisms of cl that occur during cisplatin induced nephrotoxicity by examining the genome wide mrna expression profiles of hek 293 -cells. | 2010 | 20840446 |
| curcumin protects against nmda-induced toxicity: a possible role for nr2a subunit. | curcumin, a phenolic compound extracted from the rhizome of curcuma longa, was found to attenuate nmda-induced excitotoxicity in primary retinal cultures. this study was conducted to further characterize curcumin neuroprotective ability and analyze its effects on nmda receptor (nmdar). | 2011 | 20861489 |
| the role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders ii: alzheimer's disease. | the present review is part ii in a series (part i focuses on parkinson's disease) that addresses the value of natural product chemistry in the discovery of medicines for the treatment of neurodegenerative disorders. data reviewed document that a host of products from plant species and derivatives have neuroprotectant effects in vitro and in vivo. in addition, besides neuroprotection, natural products also demonstrate biological effects that target biochemical pathways underlying associated sympt ... | 2011 | 20874701 |
| curcumin inhibits the proliferation of human hepatocellular carcinoma j5 cells by inducing endoplasmic reticulum stress and mitochondrial dysfunction. | curcumin (diferuloylmethane), which is obtained from turmeric, the rhizome of curcuma longa (l.), inhibits many human cancer cells. however, the molecular mechanisms responsible for curcumin-induced endoplasmic reticulum stress in human hepatic cellular carcinoma j5 cells, are not yet clearly understood. j5 cells were treated with various concentrations of curcumin for different durations. the cell viability was detected by mtt assay. the protein expressions of caspase-12, atf6, gadd153, calnexi ... | 2010 | 20878089 |
| effect of ocimum sanctum, turmeric extract and vitamin e supplementation on the salivary gland and bone marrow of radioiodine exposed mice. | significant increase in the salivary gland weight was observed after exposure to single therapeutic dose of 3.7 mbq of 131i in mice. pre-supplementation of antioxidants, o. sanctum leaf extract, turmeric extract and vitamin e for 15 days before 131i exposure demonstrated significant reduction in the salivary gland weight. no major histopathological changes were observed in the salivary gland of experimental animals at 24 h of exposure. micronuclei index in the bone marrow of polychromatic (pces) ... | 2010 | 20882758 |
| the protective effects of curcuma longa linn. extract on carbon tetrachloride-induced hepatotoxicity in rats via upregulation of nrf2. | this study was designed to investigate the potentially protective effects of curcuma longa linn. extract (cle) on carbon tetrachloride (ccl4)-induced hepatotoxicity in rats. male sprague-dawley rats were pretreated with 50 or 100mg/kg of cle or 100mg/kg of butylated hydroxytoluene (bht) for 14 days before ccl4 administration. in addition, the cle control group was pretreated with 100mg/kg cle for only 14 days. three hours after the final treatment, a single dose of ccl4 (20mg/kg) was administrat ... | 2010 | 20890099 |
| curcumin attenuates the effects of transport stress on serum cortisol concentration, hippocampal no production, and bdnf expression in the pig. | curcumin, the active component of curcuma longa, has been reported to be effective in alleviating chronic stress-induced disorders in rodents by modulating neuroprotection and neuroendocrine functions of the central nervous system, especially hippocampus. however, it is unclear whether curcumin can attenuate the subacute stress response induced by 2 h of road transport in the pig. therefore, the present study was designed to identify the changes of serum cortisol concentration, hippocampal nitri ... | 2010 | 20920780 |
| determination of fumonisin b1 in botanical roots by liquid chromatography with fluorescence detection: single-laboratory validation. | the accuracy, repeatability, and reproducibility characteristics of a published method for measuring levels of fumonisin b1 (fb1) in botanical root products were determined by an aoac single-laboratory validation procedure. replicates of 10 test portions of each powdered root product (black cohosh, echinacea, ginger, ginseng, valerian, dong quai, and turmeric) at each spiking level (fb1 at 0, 50, 100, and 200 ng/g) were analyzed on 3 separate days. test samples were extracted with methanol-aceto ... | 2010 | 20922947 |
| neuroprotective and neurorescue effects of a novel polymeric nanoparticle formulation of curcumin (nanocurc™) in the neuronal cell culture and animal model: implications for alzheimer's disease. | alzheimer's disease (ad) is characterized by deposition of amyloid-β (aβ) plaques within the brain parenchyma followed by synaptic loss and neuronal death. deposited aβ reacts with activated microglia to produce reactive oxygen species (ros) and cytochemokines, which lead to severe neuroinflammation. curcumin is a yellow polyphenol compound found in turmeric, a widely used culinary ingredient that possesses anti-inflammatory and anti-cancer properties and may show efficacy as a potential therape ... | 2011 | 20930270 |
| conundrum and therapeutic potential of curcumin in drug delivery. | turmeric, the source of the polyphenolic active compound curcumin (diferuloylmethane), has been used extensively in traditional medicine since ancient times as a household remedy against various diseases, including hepatic disorders, cough, sinusitis, rheumatism, and biliary disorders. in the past few decades, a number of studies have been done on curcumin showing its potential role in treating inflammatory disorders, cardiovascular disease, cancer, aids, and neurological disorders. however, the ... | 2010 | 20932240 |
| curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: relevance for anti-aging intervention. | curcumin, a component of the spice turmeric, was tested for its potential hormetic anti-aging effects as an inducer of mild stress. | 2010 | 20938987 |
| curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells. | cervical cancer is the most common cancer in indian females and is associated with infection with high-risk human papilloma viruses (hpvs) which encode viral oncoprotein e6 and e7. estradiol has been established as a risk factor for cervical cancer and has been shown to play a synergistic role with viral oncoproteins. curcumin (diferuloyl methane), a chemopreventive agent, is a natural compound extracted from curcuma longa that allows suppression and retardation of carcinogenesis in many types o ... | 2010 | 20941532 |
| neuroprotective effects of curcumin on 6-hydroxydopamine-induced parkinsonism in rats: behavioral, neurochemical and immunohistochemical studies. | curcumin, the active principle of turmeric used in indian curry is known for its antitumor, antioxidant, antiarthritic, anti-ischemic and anti-inflammatory properties and might inhibit the accumulation of destructive beta-amyloid in the brains of alzheimer's disease patients. a parkinsonian model in rats was developed by giving 6-hydroxydopamine (10 μg/2 μl in 0.1% ascorbic acid-saline) in the right striatum. after 3 weeks of lesioning, the behavior activities (rotarod, narrow beam test, grip te ... | 2010 | 20951685 |
| evaluation of traditional indian antidiabetic medicinal plants for human pancreatic amylase inhibitory effect in vitro. | pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post prandial hyperglycemia via control of starch breakdown. eleven ayurvedic indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory potential on pancreatic α-amylase. analysis of 91 extracts, showed that 10 exhibited strong human pancreatic amylase (hpa) inhibitory potential. o ... | 2010 | 20953430 |
| the targets of curcumin. | curcumin (diferuloylmethane), an orange-yellow component of turmeric or curry powder, is a polyphenol natural product isolated from the rhizome of the plant curcuma longa. for centuries, curcumin has been used in some medicinal preparation or used as a food-coloring agent. in recent years, extensive in vitro and in vivo studies suggested curcumin has anticancer, antiviral, antiarthritic, anti-amyloid, antioxidant, and anti-inflammatory properties. the underlying mechanisms of these effects are d ... | 2011 | 20955148 |
| inhibitory effect of epigallocatechin gallate (egcg), resveratrol, and curcumin on proliferation of human retinal pigment epithelial cells in vitro. | to investigate potential inhibitory effects of three polyphenolic agents, epigallocatechin gallate (egcg; from green tea), resveratrol (from red wine), and curcumin (from turmeric), on the proliferation of human retinal pigment epithelial (rpe) cells and to elucidate unwanted effects. | 2010 | 20958191 |
| curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-κb pathways through a crossed phosphatidylinositol 3-kinase/akt/iκb kinase complex signaling axis in adenoid cystic carcinoma. | adenoid cystic carcinoma (acc) is a highly malignant tumor that is generally unresponsive or only weakly responsive to the currently available antineoplastic agents. thus, novel therapeutic strategies and agents are urgently needed to treat this aggressive neoplasm. curcumin, a component of turmeric (curcuma longa), has been shown to have a diversity of antitumor activities. we show here that curcumin is a potent inhibitor of acc progression in vitro and in vivo. curcumin concentration-dependent ... | 2010 | 20959361 |