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[present status of zoonotic hemorrhagic fevers of south america].since 1958, the geographical distribution of argentine hemorrhagic fever (ahf) has especially extended non only into the province of buenos aires but also towards the provinces of santa fe and cordoba, leading to an estimated population at risk of about 1.2 m inhabitants. recent epidemiological field studies has confirmed the major role of calomys musculinus and c. laucha rodents in both transmission to man and conservation of junin virus in nature. however, the human infection may result essent ...19937819800
isolation, characterization and geographic distribution of caño delgadito virus, a newly discovered south american hantavirus (family bunyaviridae).rodents collected from the venezuelan llanos (plains) during field studies of viral hemorrhagic fever were tested for evidence of hantavirus infection. hantavirus antibody was found in one (7.7%) of 13 oryzomys bicolor, one (3.4%) of 29 rattus rattus, 10 (6.0%) of 166 sigmodon alstoni and one (2.2%) of 45 zygodontomys brevicauda. hantavirus-specific rna was detected in lung tissues from four antibody-positive rodents: two s. alstoni from portuguesa state and one s. alstoni each from cojedes and ...19979498614
experimental infection of the sigmodon alstoni cotton rat with caño delgadito virus, a south american hantavirus.forty-eight sigmodon alstoni (alston's cotton rat) were inoculated with caño delgadito (cdg) virus to extend our knowledge and understanding of the natural host relationships of the hantaviruses indigenous to the americas. infectious cdg virus was recovered from oropharyngeal secretions, urine, or solid tissues of nine of 12 animals killed on day 9 post-inoculation (pi), 14 of 24 animals killed on day 18 or 27 pi, and none of 12 animals killed on day 54 pi. in addition, virus-specific rna was de ...200212363052
natural host relationships of hantaviruses native to western venezuela.strains of caño delgadito virus (cadv) and maporal virus (mapv) were isolated from 25 (8.9%) of the 280 rodents captured on farms in 1997 in western venezuela. the results of analyses of laboratory and zoographic data indicated that alston's cotton rat (sigmodon alstoni) is the principal host of cadv, horizontal virus transmission is the dominant mode of cadv transmission in alston's cotton rat in nature, a pygmy rice rat (oligoryzomys sp.) is the principal host of mapv, and the natural host rel ...201020055578
involvement of pro-inflammatory macrophages in liver pathology of pirital virus-infected syrian hamsters.new world arenaviruses cause fatal hemorrhagic disease in south america. pirital virus (pirv), a mammarenavirus hosted by alston’s cotton rat (sigmodon alstoni), causes a disease in syrian golden hamsters (mesocricetus auratus) (biosafety level-3, bsl-3) that has many pathologic similarities to the south american hemorrhagic fevers (bsl-4) and, thus, is considered among the best small-animal models for human arenavirus disease. here, we extend in greater detail previously described clinica ...201829724035
genetic diversity between and within the arenavirus species indigenous to western venezuela.the results of analyses of z, rna-dependent rna polymerase, glycoprotein precursor, and nucleocapsid protein gene sequence data suggested that guanarito virus was the most common cause of venezuelan hemorrhagic fever in a 7-year period in the 1990s and that the evolution of pirital virus in association with sigmodon alstoni (alston's cotton rat) has occurred at a significantly higher rate than the evolution of guanarito virus in association with zygodontomys brevicauda (short-tailed cane mouse) ...200818586298
[a new mite species radfordia sigmomys sp. n. (acari: myobiidae) parasitizing sigmodon alstoni (rodentia: sigmodontidae) from central america].a new myobiid species radfordia (hesperomyobia) sigmomys sp. n. (acari: myobiidae) ex sigmodon alstoni (rodentia: sigmodontidae) from central america is described. this description is based from the females, proto-, dueto- and tritonymphs. female (4 spec.). body 500-510 (in micrometers) long and 295-320 wide. length of setae: ve 90-95--widely lanceolate, 10-15; vi 23-25, sci 95-105, sce 90-100, d1 80-85, d2 70-90, d3 20-25, d4 23-27, l1 75-90, l2 80-85, l3 25-27--all narrowly lanceolate; d5 10-1 ...200312815811
natural rodent host associations of guanarito and pirital viruses (family arenaviridae) in central venezuela.the objective of this study was to elucidate the natural rodent host relationships of guanarito and pirital viruses (family arenaviridae) in the plains of central venezuela. ninety-two arenavirus isolates from 607 animals, representing 10 different rodent species, were characterized to the level of serotype. the 92 isolates comprised 19 guanarito virus strains and 73 pirital virus strains. the 19 guanarito virus isolates were from zygodontomys brevicauda; 72 (98.6%) of the 73 pirital virus isola ...199910463688
isolation and characterization of pirital virus, a newly discovered south american arenavirus.specific rodent species are principal hosts for each of the well-characterized members of the virus family arenaviridae. guanarito virus (arenaviridae) is the etiologic agent of venezuelan hemorrhagic fever. a previous study on the epidemiology of venezuelan hemorrhagic fever revealed extensive arenavirus infection (presumed to be caused by guanarito virus) in two rodent species. sigmodon alstoni and zygodontomys brevicauda, collected from the region of venezuela in which the disease is endemic. ...19979180606
field studies on the epidemiology of venezuelan hemorrhagic fever: implication of the cotton rat sigmodon alstoni as the probable rodent reservoir.during february 1992, field studies on the epidemiology of venezuelan hemorrhagic fever (vhf) were carried out in a rural area of portuguesa state in central venezuela. the objective of this work was to determine the prevalence of infection with guanarito virus, the etiologic agent of vhf, among wild rodents and humans living within an endemic focus of the disease. a total of 234 rodents, representing nine different species, were collected and their spleens were cultured for virus. thirty-one gu ...19938395143
transmission of guanarito and pirital viruses among wild rodents, venezuela.samples from rodents captured on a farm in venezuela in february 1997 were tested for arenavirus, antibody against guanarito virus (gtov), and antibody against pirital virus (pirv). thirty-one (48.4%) of 64 short-tailed cane mice (zygodontomys brevicauda) were infected with gtov, 1 alston's cotton rat (sigmodon alstoni) was infected with gtov, and 36 (64.3%) of 56 other alston's cotton rats were infected with pirv. the results of analyses of field and laboratory data suggested that horizontal tr ...201122172205
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