Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [study of screening pseudoallergenic substances of shuanghuanglian injection]. | in this study, chemistry, biology and pharmacology were combinated to screen pseudoallergenic substances of shuang-huanglian injection (shli) so that to establish a scientific and systematic approach to screen pseudoallergenic substances of traditional chinese medicine injections. the mouse pseudoallergic reaction models were used to screen the pseudoallergic reaction of shli's intermediate extract and the intermediate extract's component or ingredient. among the three intermediates of shuanghua ... | 2015 | 26666017 |
| metabolic profile of phillyrin in rats obtained by uplc-q-tof-ms. | forsythia suspensa vahl (oleaceae) is an important original plant in traditional chinese medicine. the air-dried fruits of forsythia suspensa have long been used to relieve respiratory symptoms. phillyrin is one of the main chemical constituent of forsythia suspensa. a clear understanding of the metabolism of phillyrin is very important in rational clinical use and pharmacological research. in this study, the metabolism of phillyrin in rat was investigated for the first time using an ultra-high- ... | 2016 | 26425840 |
| forsythiaside a exhibits anti-inflammatory effects in lps-stimulated bv2 microglia cells through activation of nrf2/ho-1 signaling pathway. | inflammation and oxidative stress have been reported to play critical roles in the pathogenesis of neurodegenerative disease. forsythiaside a, a phenylethanoside product isolated from air-dried fruits of forsythia suspensa, has been reported to have anti-inflammatory and antioxidant effects. in this study, the anti-inflammatory effects of forsythiaside a on lps-stimulated bv2 microglia cells and primary microglia cells were investigated. the production of inflammatory mediators tnf-α, il-1β, no ... | 2016 | 26498935 |
| chinese vegetative materia medica in a venereological treatise by jean astruc from 1740. | historical medical sources can be still queried for forgotten cures and remedies. traditional chinese medicine has dealt with lues venerea (syphilis) since the five dynasties period (10th century). chinese indigenous materia medica and remedies recorded, studied or imported by the europeans can reveal known or quite unknown medicinal plants. the studied jean astruc's work is a published ethnopharmacological survey carried out in beijing in the 1730s and it deserves a modern interpretation. | 2016 | 27132716 |
| forsythia suspensa suppresses house dust mite extract-induced atopic dermatitis in nc/nga mice. | forsythia suspensa (f. suspensa) is a traditional medicine for treatment of inflammation. in this study, we evaluated the therapeutic effects of an ethanol extract from f. suspensa fruits on atopic dermatitis both in vivo and in vitro. we investigated the inhibitory effects of f. suspensa extract on the development of atopic dermatitis-like skin lesions in an nc/nga mouse model exposed to dermatophagoides farinae crude extract. topical application of f. suspensa extract to the mice attenuated th ... | 2016 | 27936051 |
| phytochemical profiling in single plant cell by high performance liquid chromatography-mass spectrometry. | phytochemicals are essential secondary plant metabolites which play important roles in the areas of plant biochemistry, pharmacy and medical science because of their significant bioactivities. conventional analysis of phytochemicals in plants needs a complex combination of different extraction and separation steps. here a simple and universal method for profiling phytochemicals in a single plant cell was demonstrated based on high performance liquid chromatography-mass spectrometry. single purpl ... | 2016 | 27722487 |
| effect of forsythia suspensa extract and chito-oligosaccharide alone or in combination on performance, intestinal barrier function, antioxidant capacity and immune characteristics of weaned piglets. | we investigated the effects of forsythia suspensa extract (fse) and chito-oligosaccharide (cos), alone or together, on performance and health status of weaned piglets. the treatments included a basal diet and three diets with 160 mg/kg cos, 100 mg/kg fse, or 100 mg/kg fse and 160 mg/kg cos. supplementation with cos or fse alone improved (p < 0.01) average daily gain and feed conversion ratio compared with the basal diet in the first 2 weeks. on day 14, cos or fse supplementation separately produ ... | 2016 | 27758020 |
| forsythiae fructus inhibits b16 melanoma growth involving mapks/nrf2/ho-1 mediated anti-oxidation and anti-inflammation. | forsythiae fructus, the fruits of forsythia suspensa (thunb.) vahl, lianqiao in chinese, is one of the most fundamental herbs in traditional chinese medicine (tcm). it is a typical heat-clearing and detoxicating herb, according to tcm theory. in this study, we investigated the antitumor effect of forsythiae fructus aqueous extract (fae) on b16-f10 melanoma cells in vivo. the transplanted b16-f10 melanoma in c57bl/6 mice was established and used for the evaluation of the in vivo antitumor effect ... | 2016 | 27430915 |
| antidiabetic and antihyperlipidemic activities of forsythia suspensa (thunb.) vahl (fruit) in streptozotocin-induced diabetes mice. | the fruit of forsythia suspense (thunb.) vahl, a well-known chinese materia medica, has been traditionally used in traditional chinese medicine for the treatment of diabetes and some other diseases, but the rational for the usage of this plant is unclear. the aim of this study was to investigate the therapeutic effect and potential mechanism of the fruit of f. suspensa using streptozotocin (stz)-induced diabetic mice. | 2016 | 27377336 |
| ionic liquid-based ultrasonic-assisted extraction of forsythosides from the leaf of forsythia suspensa (thunb.) vahl and subsequent separation and purification by high-speed counter-current chromatography. | an ionic liquid-based ultrasonic-assisted extraction (iluae) method was developed for the extraction of the two forsythosides, namely forsythosides i and a from the leaf of forsythia suspensa (thunb.) vahl. three kinds of l-alkyl-3-methylimidazolium ionic liquids with different alkyl chain and anion were investigated. the results indicated that ionic liquids showed remarkable effects on the extraction yields of forsythosides. in addition, several iluae ultrasonic parameters, such as the solvent ... | 2016 | 27165571 |
| forsythia suspensa fruit extracts and the constituent matairesinol confer anti-allergic effects in an allergic dermatitis mouse model. | forsythia suspensa is used in traditional medicine to treat inflammation. to clarify the anti-inflammatory and anti-allergic effects of f. suspensa fruits, we determined the therapeutic effects of crude extract, fractions, and a constituent from f. suspensa fruits on a murine atopic dermatitis (ad) model. | 2016 | 27085937 |
| identifying chinese herbal medicine network for treating acne: implications from a nationwide database. | acne is a highly prevalent inflammatory skin disease which causes patients great psychological stress, especially teenagers. chinese herbal medicine (chm) is commonly used to treat acne with personalized but complicated prescriptions. the aim of this study is to determine a chm network and core chm treatments for acne by analyzing a nationwide database. | 2016 | 26721214 |
| polyhydroxytriterpenoids and phenolic constituents from forsythia suspensa (thunb.) vahl leaves. | forsythia suspensa (thunb.) vahl leaves have been consumed in china as a health-promoting functional tea for centuries. three new polyhydroxytriterpenoid glycosides named suspensanosides a-c (1-3), seven known polyhydroxytriterpenoids (4-10), and 12 known phenolics (11-22) were identified from f. suspensa leaves. compounds 1-10, 15-17, and 22 have not been found in the forsythia genus previously, whereas compound 14 was first reported to be isolated from the leaves of f. suspensa. all isolates w ... | 2016 | 26694205 |
| forsythia suspensa extract attenuates lipopolysaccharide-induced inflammatory liver injury in rats via promoting antioxidant defense mechanisms. | reactive oxygen species (ros) have been shown to have a role in inflammation. we investigated whether forsythia suspensa extract (fse) could exert its antioxidant potential against lipopolysaccharide (lps)-induced inflammatory liver injury in rats. rats were orally fed fse once daily for 7 consecutive days prior to lps (escherichia coli, serotype o55:b5) injection. lps treatment caused liver dysfunction as evidenced by massive histopathological changes and increased serum alanine aminotransferas ... | 2016 | 27753186 |
| effects of phillyrin and forsythoside a on rat cytochrome p450 activities in vivo and in vitro. | 1. phillyrin and forsythoside a are two important active ingredients in forsythia suspensa. however, the effects of phillyrin and forsythoside a on the activities of cytochrome p450 (cyp450) remain unclear. 2. this study aimed to investigate the effects of phillyrin and forsythoside a on the activities of cyp1a2, cyp2c11, cyp2d1 and cyp3a1/2 by cocktail probe drugs in rats both in vivo and in vitro. 3. many pharmacokinetic parameters of caffeine and metoprolol in phillyrin pretreatment group, ca ... | 2017 | 27310729 |
| chemical constituents and anti-inflammatory principles from the fruits of forsythia suspensa. | fifty compounds were isolated from the fruits of forsythia suspensa, including 13 new compounds characterized as eight new diterpenoids (1-8), three new lignans (9-11), a new iridoid (12), and a new triterpenoid (13). their structures were established on the basis of spectroscopic and spectrometric analysis. most of the isolated compounds were examined for their anti-inflammatory activity in vitro. the results showed that several compounds displayed significant inhibition of fmlp/cb-induced supe ... | 2017 | 28218000 |
| evaluating the safety of forsythin from forsythia suspensa leaves by acute and sub-chronic oral administration in rodent models. | to access the toxicity of forsythin from forsythia suspensa leaves and evaluate its safety. | 2017 | 28107864 |
| comparative evaluation of raw and ripe fruits of forsythia suspensa by hplc-esi-ms/ms analysis and anti-microbial assay. | a multi-component quantification fingerprint based on high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry technique has been established for the comparative analysis of raw and ripe fruits of forsythia suspensa originated from different provinces. eighteen bioactive constituents including three phenylethanoid glycosides derivatives, six phenolic acids, three flavonoids, four phenylpropanoids, one fatty acid and one terpenoid were identified and qu ... | 2017 | 28069689 |