Publications

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fatal lymphoproliferative disease associated with a novel gammaherpesvirus in a captive population of common marmosets.callitrichids (marmosets and tamarins) are extremely susceptible to experimental tumor induction by herpesviruses native to other primate species. a colony of common marmosets developed a syndrome of weight loss, inappetence, diarrhea, and in several animals, palpable abdominal masses.200010987671
complete genomic sequence of an epstein-barr virus-related herpesvirus naturally infecting a new world primate: a defining point in the evolution of oncogenic lymphocryptoviruses.callitrichine herpesvirus 3 (calhv-3) was isolated from a b-cell lymphoma arising spontaneously in the new world primate callithrix jacchus, the common marmoset. partial genomic sequence analysis definitively identified calhv-3 as a member of the epstein-barr virus (ebv)-related lymphocryptovirus (lcv) genus and extended the known host range of lcvs beyond humans and old world nonhuman primates. we have now completed the first genomic sequence of an lcv infecting a new world primate by describin ...200212414947
novel gamma-1 herpesviruses identified in free-ranging new world monkeys (golden-handed tamarin [saguinus midas], squirrel monkey [saimiri sciureus], and white-faced saki [pithecia pithecia]) in french guiana.the recent finding of a novel epstein-barr virus-related lymphocryptovirus (calhv-3) in a captive colony of common marmoset (callithrix jacchus) in the united states modifies the view that the host range of lymphocryptovirus is restricted to humans and old world primates. we investigated the presence of epstein-barr virus-related viruses in 79 samples of new world monkeys caught in the wild, including six species of the cebidae family and one of the callitrichidae, living in the rain forest of f ...200312885928
novel simian homologues of epstein-barr virus.thirty different lymphocryptoviruses (lcv), 26 of them novel, were detected in primates by a panherpesvirus pcr assay. nineteen lcv from chimpanzees, bonobos, gorillas, and other old world primates were closely related to epstein-barr virus (ebv), the type species of the genus lymphocryptovirus. seven lcv originating from new world primates were related to callitrichine herpesvirus 3 (calhv-3), the first recognized new world lcv. importantly, a second lcv from gorillas and three lcv from orangut ...200312970457
compatibility of the gh homologues of epstein-barr virus and related lymphocryptoviruses.glycoprotein gh, together with its chaperone gl and a third glycoprotein gb, is essential for cell-cell fusion and virus-cell fusion mediated by herpesviruses. epstein-barr virus (ebv), the prototype human lymphocryptovirus, requires a fourth glycoprotein gp42 to support fusion with b cells in addition to epithelial cells. two other lymphocryptoviruses, the rhesus lymphocryptovirus (rh-lcv) and the common marmoset lymphocryptovirus (calhv3), have been sequenced in their entirety and each has a g ...200717622614
genetic diversity and molecular evolution of human and non-human primate gammaherpesvirinae.the gammaherpesvirinae sub-family is divided into two genera: lymphocryptovirus and rhadinovirus. until the middle of the 1990s, the rhadinovirus genus was only represented by herpesvirus saimiri and herpesvirus ateles, which infect new world monkey species. until the year 2000, epstein-barr virus (ebv), the human prototype of the lymphocryptovirus, and simian homologues had only been detected in humans and old world non-human primates. it was thought, therefore, that the separation of the conti ...201019879975
small intestinal adenocarcinoma in common marmosets (callithrix jacchus).small intestinal adenocarcinomas are uncommon neoplasms that are rarely reported in nonhuman primates. these neoplasms are also rare in humans, although they are thought to share a similar pathogenesis with the more common colorectal carcinoma. herein the authors report the clinical, histologic, immunohistochemical, and molecular characteristics of small intestinal adenocarcinoma in 10 common marmosets (callithrix jacchus). retrospective analysis of necropsy records revealed small intestinal car ...201020460447
the primate eae model points at ebv-infected b cells as a preferential therapy target in multiple sclerosis.the remarkable clinical efficacy of anti-cd20 monoclonal antibodies (mab) in relapsing-remitting multiple sclerosis points at the critical involvement of b cells in the disease. however, the exact pathogenic contribution of b cells is poorly understood. in this publication we review new data on the role of cd20+ b cells in a unique experimental autoimmune encephalomyelitis (eae) model in common marmosets (callithrix jacchus), a small-bodied neotropical primate. we will also discuss the relevance ...201323781220
the different clinical effects of anti-blys, anti-april and anti-cd20 antibodies point at a critical pathogenic role of γ-herpesvirus infected b cells in the marmoset eae model.the robust and rapid clinical effect of depleting anti-cd20 monoclonal antibodies (mab) in multiple sclerosis (ms) demonstrates a critical pathogenic contribution of b cells. the clinical effect of anti-cd20 mab has been replicated in a relevant preclinical ms model, experimental autoimmune encephalomyelitis (eae) in marmoset monkeys (callithrix jacchus). by contrast, treatment with mabs against two essential cytokines in b cell activation growth and survival, i.e. blys/baff and april, was only ...201323508625
ebv bilf1 evolved to downregulate cell surface display of a wide range of hla class i molecules through their cytoplasmic tail.coevolution of herpesviruses and their hosts has driven the development of both host antiviral mechanisms to detect and eliminate infected cells and viral ploys to escape immune surveillance. among the immune-evasion strategies used by the lymphocryptovirus (γ(1)-herpesvirus) ebv is the downregulation of surface hla class i expression by the virally encoded g protein-coupled receptor bilf1, thereby impeding presentation of viral ags and cytotoxic t cell recognition of the infected cell. in this ...201323315076
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