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photomyoclonic seizures in the baboon, papio papio.the inborn seizure response of papio papio to intermittent light stimulation has been reviewed as a model of human epilepsy. the electrographic and clinical features have been described and useful methodology has been outlined. a diurnal cyclicity in seizure responsiveness has been described with greatest seizure severity at 8 am in parallel with a rise in urinary output of cortisol. hormonal influences on the seizure response have been described for ethinyl estradiol, thyroxin, and triiodothyro ...197939008
[an electrophysiological study of direct occipito-frontal connections in centrum semi-ovale of papio papio].1. evoked responses to single visual stimuli (vep) and driving by intermittent light stimulation (ils) were recorded with macroelectrodes from the central white matter (centrum semiovale) of 12 papio papio baboons. 2. two types of vep were identified: veps with constant morphology, localized in the long associative bundles connecting the occipital, temporal and frontal lobes; veps with variable morphology and without any preferential localization; these probably originate from other types of fib ...197545946
proceedings: spontaneous spike and wave with anterior distribution in association with fits induced by photic stimulation in papio papio. report of a case. 197552534
the sleep of the baboon, papio papio, under natural conditions and in the laboratory.the sleep pattern of sixteen baboons (papio papio) was studied under two very different conditions: (1) in a laboratory at marseilles, the monkey being immobilized in a restraining chair in a soundproof cubicle; (2) in an african reserve, the monkey being housed in a large cage placed in its natural environment. some very marked differences emerged. sleep in the laboratory was longer (by 24 min) and richer in stage 3 and paradoxical sleep. in africa, however, the sleep showed much more stage 1, ...197553145
[eeg effects of sodium nitroprusside and hemodynamic references].a study was performed on baboons (papio papio) of various hemodynamic and eeg effects of sodium nitroprussiate (snp), substance with powerful vasodilator action. three different procedures of drug injection were used: (1) in isolation, either in doses close to those used in clinical practice or in high doses; (2) after neuroleptanalgesia (nla); (3) after causing vasospasm. with isolated snp, effects on blood pressure were unstable; in certain cases hypotension could be maintained only with toxic ...197656263
effects of melatonin on the photosensitive epilepsy of the baboon, papio papio.the acute pharmacological effects of melatonin (5-methoxy-n-acetyl-tryptamine) were evaluated on behaviour and electrographic signs in the photosensitive baboon (papio papio), including visually evoked potentials veps). doses of 5 and 10 mg/kg i.v. had little effect, contrasting with the enhancement of spontaneous paroxysmal activity and latency of clinical signs elicited by intermittent light stimulation (ils) produced by the 20 and 50 mg/kg doses. moreover, a modification of the electrographic ...200160219
[action of ketamine of paroxysmal discharges provoked by air emboli in the baboon papio papio].ketamine was administered to 18 baboons (papio papio) to disrupt epileptic discharges elicited through intracarotid air injection. discharge suppression was obtained in all animals but could be preceded by a phase of enhancement of the epileptic patterns, which rendered necessary the injection of a supplementary dose. the mechanisms of ketamine action are discussed, in connection with data from the literature. some of the latter suggest that its use in proved epileptics facilitates paroxystic pa ...197660222
type c viruses from kirsten sarcoma-transformed mink cells co-cultivated with primate cells and expressing p30 antigens related to feline leukemia virus.two type c viruses with new antigenic and biological properties were isolated by co-cultivating secondary cell strains established from the kidneys of a baboon (papio papio) and a patas monkey (erythrocebus patas) with mink cells non-productively transformed by kirsten sarcoma virus. both new isolates (designated pp-1r and ep-1r) contain major structural proteins (p30) that are immunologically most closely related to the p30 proteins of feline leukemia viruses. the reverse transcriptases of both ...197660495
epilepsy and sleep organization in the baboon papio papio.effects of different types of epileptic seizure on the sleep organization of baboon were studied through 12 h polygraphic recordings. photically induced myoclonic jerking did not modify sleep organization. photically induced genalized convulsions produced an increase of the waking stage (awa) and reduction of rem stage. pentetrazol-induced generalized convulsions not only increased awa and reduced rem, but also elicited various modifications of stages i, ii and iii. daily generalized convulsions ...197662652
negative effects of chronic hemicerebellectomy of epileptiform after-discharges elicited by focal cortical stimulation in baboons (papio papio).the influence of chronic hemicerebellectomy on cortical epileptiform after-discharge (ad) induced by focal electrical stimulation was studied in the baboon. these preliminary results include 22 ads elicited from motor cortex and 22 ads elicited from premotor cortex before and after hemicerebellectomy. only full-developed, generalized seizures with postictal silence were considered. eeg morphology, average duration and average current threshold were compared for each set of ictal events. no signi ...197875096
myoclonus developing after vermisectomy in photosensitive papio papio.two vermisectomized photosensitive baboons exhibited two different types of myoclonus, one induced by intermittent light stimulation (ils) and the other occuring "spontaneously". the characteristics of these two types of myoclonus are described from a clinical and from an ecog point of view. myoclonus induced by ils (ml) started at the eyelids and secondarily invaded the face and body; it was always preceded by frontorolandic spike-waves or polyspike-waves. the "spontaneous" myoclonus which foll ...197878825
comparison of the karyotypes of four cercopithecoidae: papio papio, p. anubis, macaca mulatta, and m. fascicularis.the karyotypes of two species of baboons, papio papio and p. anubis, and of two species of macaca, m. mulatta and m. fascicularis, are compared after the use of numerous banding techniques. no difference was detected between the karyotype of the two papio species. however, a minor change in the t-staining of a short segment, probably heterochromatic, could be detected between the papio species and m. mulatta. a paracentric inversion exists between these three and m. fascicularis. these karyotype ...197983931
proconvulsant, convulsant and other actions of the d- and l-stereoisomers of allylglycine in the photosensitive baboon, papio papio.the effects of the intravenous or intracerebroventricular injection of the stereoisomers, and the racemic mixture, of allylglycine (2-amino-pent-4-enoic acid) have been studied in baboons, papio papio, with photosensitive epilepsy. enhancement of the natural syndrome of photosensitivy epilepsy is seen 1-12 h (maximally at 3-8 h) after l-allyglycine, 100 mg/kg, intravenously, or d,l-allyglycine, 200 mg/kg, intravenously. such enhancement is seen with a slower onset, and to a lesser, and more vari ...200089942
the influence of cortisone on eeg and seizure activity in the baboon papio papio.the ability of cortisone to modify eeg and seizure activity was investigated in the baboon, papio papio. acute intramuscular doses (0.5-4 mg/kg) caused a dose-dependent increase in seizure response to a flashing light stimulus. this increase in seizure response was apparent in both seizure duration and the spread of convulsive activity. along with enhancement of seizures, cortisone was found to cause marked changes in the eeg, ranging from the appearance of interictal paroxysmal activity to alte ...200089944
red cell and serum enzymes of guinea baboon (papio papio).variants of some erythrocyte and serum enzymes have been studied among several blood samples of guinea baboon (papio papio). variation occurred in two red cell enzymes, g6pd and nadh diaphorase, and in serum esterase. all studied animals had a complete uniformity in other enzyme systems (acp, 6pgd, ca, ak, and cholinesterase at e1 locus). data obtained in the present work have been discussed and compared with those reported among other baboon species.197896267
blockade of photically induced epilepsy by 'dopamine agonist' ergot alkaloids.the effect of the intravenous administration of ergot alkaloids on epileptic responses to intermittent photic stimulation )ips) has been studied in adolescent baboons, papio papio, from senegal. ergocornine, 1--2 mg/kg, produced marked autonomic and behavioural effects, slowed the eeg, and abolished myoclonic responses to ips for 30--90 min. ergometrine, 1 mg/kg, activated the eeg and blocked the induction of myoclonic responses for 1--3 h. bromocriptine, 0.5--4 mg/kg, did not consistently preve ...199996470
complete or almost complete analogy of chromosome banding between the baboon (papio papio) and man. 197897206
anticonvulsant action of a 1,5-benzodiazepine, clobazam, in reflex epilepsy.clobazam, an anxiolytic 1,5-benzodiazepine, has been evaluated as an anticonvulsant in 2 animal models. in mice showing sound induced seizures, clobazam, 1--4 mg/kg, i.p., blocked seizure responses for 1--2 hr. in senegalese baboons papio papio showing photically induced myoclonus or seizures, clobazam, 2--12 mg/kg, i.v., totally prevented such responses for up to 6 hr. in baboons pretreated with allylglycine, 170--185 mg/kg, a similar but briefer protection was induced by clobazam. neurological ...200198317
alterations in learning performance in the seizure-prone baboon: effects of elicited seizures and chronic treatment with diazepam and phenobarbital.a comparison was made of the effects of chronically administered diazepam and phenobarbital with those of elicited seizures on repeated acquisition learning in 3 prepubertal papio papio. the learning task required the baboons each day to perform different sequences of lever presses on a three-lever behavior panel. middle dose levels of both diazepam and phenobarbital were found to improve learning performance relative to base-line control levels, as measured by total errors, efficiency, and time ...200198318
[pharmacologic approach to papio papio photosensitive epilepsy]. 197898965
blockade of epileptic responses in the photosensitive baboon, papio papio, by two irreversible inhibitors of gaba-transaminase, gamma-acetylenic gaba (4-amino-hex-5-ynoic acid) and gamma-vinyl gaba (4-amino-hex-5-enoic acid).the anticonvulsant potency and neurological toxicity of two new catalytic inhibitors of gaba-transaminase have been assessed in acute experiments in baboons with a natural syndrome of photic epilepsy. gamma-acetylenic gaba, 160--200 mg/kg, or gamma-vinyl gaba, 450--950 mg/kg, intravenously, gave complete protection against generalised myoclonus or seizure responses induced by photic stimulation (in baboons without or with priming with subconvulsant doses of allylglycine). the protection became m ...1978100812
[candidiasis and obstructive intestinal tumor in a captive baboon 'papio papio' (desm.)].report of a case of candidiasis of the digestive tract associated to an obstructive epithelial tumor, with great invasive ability, in a captive baboon, papio papio (desm.). included is a discussion of the incidence of some intestinal disturbances involving candidiasis of subhuman primates.1978104181
secondarily generalized convulsive seizures induced by daily amygdaloid stimulation in rhesus monkeys.amygdaloid kindling in rhesus monkeys resulted in development of secondarily generalized convulsive seizures in an average of 196 days. prior pharmacologic (bemegride) kindling accelerated this seizure development in one animal. none of the animals reached the stage 5 primary generalized seizure of baboons (papio papio), even after 400 daily amygdaloid stimulations. seizure stage instability, with frequent regression to an earlier stage, and the difficulty of establishing a generalized seizure t ...1978106328
anticonvulsant activity in photosensitive baboons, papio papio, of two new 1,5 benzodiazepines.two new 1,5 benzodiazepines have been evaluated acutely as anticonvulsants in baboons, papio papio, with photosensitive epilepsy. bau 426 (8-chlor-6-[2-chlorphenyl]-4h-s-triazolo-[4,3-a] [1,5-benzodiazepin-5-[6-h]on) and bau 500 (analogue of bau 426 with [2-trifluor methylphenyl] substituted for [2-chlorphenyl]), 0.1--5.0 mg/kg, were administered i.v. to baboons with and without priming with d,l allylglycine. bau 426 or bau 500, 0.1--0.2 mg/kg, produced partial or transient protection against ph ...1979108705
[desmodonte renewal in baboons (papio papio)].turnover of desmodontal ligament is analysed in the baboon using labeling, biochemical and histological techniques. in baboons, as previously observed in rodents, turnover of proteins labelled by 3h glycine may be described by a single exponential after the ninth day, the half life of which is more than two weeks. biochemical data show that proteins renewed are mostly collagen.1979109222
rapid evolution of animal mitochondrial dna.mitochondrial dna was purified from four species of higher primates (guinea baboon, rhesus macaque, guenon, and human) and digested with 11 restriction endonucleases. a cleavage map was constructed for the mitochondrial dna of each species. comparison of the maps, aligned with respect to the origin and direction of dna replication, revealed that the species differ from one another at most of the cleavage sites. the degree of divergence in nucleotide sequence at these sites was calculated from th ...1979109836
anticonvulsant action of yg 19-256 in baboons with photosensitive epilepsy.yg 19-256, 4-(1,3,4,9b-tetrahydro-5 methyl-2h-indeno[1,2-c]pyridine-2-yl)-2-butanone methane sulphonate, 1-3 mg/kg i.v., abolished or reduced photically-induced myoclonic responses for 1.5-6.5 h in baboons, papio papio, without producing signs of acute neurological toxicity.1979111964
electroencephalographic and behavioral effects of a gaba agonist (muscimol) on photosensitive epilepsy in the baboon, papio papio.muscimol, 0.25-1.0 mg/kg, i.v., was administered acutely to 4 adolescent baboons, papio papio, that show photically induced epilepsy. on the eeg, slowing of background rhythms was associated with the appearance of spikes, polyspikes, and recurring symmetrical spike-wave complexes. these changes were maximal 0.5-2 hr after muscimol injection. regular testing with intermittent light stimulation showed either no change from control responses or a more severe epileptiform eeg 0.1-3 hr after muscimol ...1979113208
maternal-fetal transfer of melatonin in the non-human primate.melatonin was detected in the circulation of the near-term rhesus monkey (macaca mulatta) and baboon (papio papio) fetus. we determined whether the source could be the mother by studying placental transfer of melatonin in the rhesus monkey. when [3h]melatonin was administered i.v. to the mother it promptly appeared in the fetal circulation; the rates of disappearance of [3h]melatonin in the maternal and fetal circulations were parallel. the rapid decrease in circulating [3h]melatonin was associa ...1979113767
photically induced seizures in the yellow baboon, papio cynocephalus.significant susceptibility to photically induced seizures has in the past been observed only in senegales baboons (papio papio) and epileptic humans. however, we have unexpectedly observed a photomyoclonic response to intermittent photic stimulation in 5 of a sample of 6 yellow baboons (papio cynocephalus).2001114296
[identity of karyotypes of papio papio and macaca mulatta in r, g, c banding and ag-nor]. 1978115371
contribution of vision to muscle responses in monkey during free-fall: visual stabilization decreases vestibular dependent responses.in a previous study the muscle responses from the lower limbs were studied in the baboon (papio-papio) during sudden falls. on the other hand, recent findings concerning the role of vision in the control of posture during rapid perturbations in man have stimulated the present investigation. emg activities were recorded from the fully conscious animal using chronic electrodes implanted in various muscles (splenius, quadriceps femoris, soleus, and tibialis anterior). for testing, the monkey was se ...1979115701
liver microsomal oxidations in baboon (papio papio).1. the activity of baboon (papio papio) hepatic microsomes was evaluated using several model substrates. 2. as with other species studied in this laboratory, baboon microsomal enzyme activities were in the decreasing order: aldrin epoxidation greater than p-nitroanisole o-demethylation greater dihydroisodrin hydroxylation greater than benzo(a)pyrene oxidations. 3. substrate, time, protein and cofactor requirements were examined. 4. activities of stored frozen tissue and microsomal pellets remain ...1979117644
[correlation between the regional blood volume and epileptic seizures in papio papio].the method of labelling red cells with technetium-99m was used to measured regional blood volume auring different types of epileptic seizures induced in the baboon papio papio. during seizures the cerebral blood volume increases and there is simultaneously a decrease of blood volume in nasal and hepatic regions, and a transitory increase of blood volume in the forepaws.2002117933
osteosarcoma of the mandible of a baboon (papio papio): morphological and virological (oncornavirus) studies, with a review of neoplasms previously described in baboons. 1979118988
[effect of cannabis on learning in the cynocephalic monkey (papio papio)].chronic treatment of monkeys with cannabis reduce the speed of acquisition of learned behavior, yet, learning is nevertheless possible. after acquisition, cannabis administration disturb the responses in the learning test. in this two experimental procedures, tolerance occurs to the effects of cannabis.1975126742
[histochemical study of the facial nerve and of several muscles in papio papio suffering from facial spasm].facial nerve neurectomy were performed in the baboon (papio papio). histochemical investigations showed usual criteria of such lesions. therefore a loose of glycogene within the type i muscular fibers was observed in animals with a former facial spasm.1975129207
serum dehydroepiandrosterone and dehydroepiandrosterone sulphate in baboon (papio papio) pregnancy.dehydroepiandrosterone (d) and dehydroepiandrosterone sulphate (ds) concentrations were determined by radioimmunoassay in peripheral sera of non-pregnant, pregnant (55 days to term) and newborn baboons and in umbilical sera of animals delivered by caesarean section close to term. d concentrations (mean +/- sd, microng/100 ml, n) in non-pregnany animals (1.61 +/- 1.32, 23) were not different (p greater than 0.05) from those during pregnancy (1.80 +/- 1.21, 101). ds concentrations, expressed as un ...1977141185
contribution of dehydroepiandrosterone and its sulfate to estradiol in baboon pregnancy.the metabolic clearance rates (mcr), conversion ratios (c), interconversion (rho), production rates (pr), secretion rates (sr), and relative contributions of maternal dehydroepiandrosterone (d) and d-sulfate (ds) to serum estradiol (e2) were determined in five pregnant baboons (papio papio; 154-167 days gestation, term = 184 days) by constant intravenous infusion of [3h]ds and [14c]d. mcr-d (mean +/- se) was greater (39.2 +/- 3.3 1/day.kg, p less than 0.001) than mcr-ds (3.1 +/- 0.3 1/day.kg). b ...1978150235
[generic characteristics and specific characteristics of the ponto-geniculo-occipital spike activity (pgo) in 2 baboons, papio hamadryas and papio papio]. 1975167907
[spike activity recorded at the level of optic tract in a primate, papio papio].spike activity has been recorded, in two young baboons, at the part of the optic tract (o.t.) localized between the chiasma and the lateral geniculate (l.g.) during rem and also slow wave sleep, preceding or not a rem period. these spikes, mono or biphasic, were of 60-200 ms duration and of 30-140 muv amplitude. they occurred generally in bursts (up to 50 spikes); 4 to 10 spikes bursts were the more frequent. these o.t. spikes were assimilated to the l.g. spikes.1975171037
[evolution of visual evoked responses during various states of vigilance in papio papio (author's transl)].averaged evoked responses (aer) to light flashes were recorded in baboons (papio papio) during wakefulness, slow-wave sleep and rapid eye movement (rem) periods, at the visual cortex, retrocalcarine sulcus, optic tract (ot), lateral geniculate (lg) and pulvinar. waking aers were composed: in the ot, of a negative, low amplitude wave at 13.3 msec (i), a high amplitude wave at 34.8 msec (ii), a negative wave at 72 msec (iii) and a late component at 151 msec; in the lg, a small positive wave (ii) w ...1975172195
utilization of dehydroepiandrosterone and its sulphate for oestrogen production by pregnant baboons (papio papio).the effect of varying maternal circulating 3beta-hydroxy-5-androsten-17-one (d) and its sulphate (ds) on urinary oestrogen (oe) excretion by baboons was determined between 65 and 174 days gestation (term = 184 days). oe (mainly oestrone) was determined by radioimmunoassay after enzymic hydrolysis of conjugates. increments in oe were estimated from the difference between oe during 5 days pre- and post-treatment. oestradiol-17beta (5 mg in 5.0 ml saline-ethanol, 1:1) administered iv increased (p l ...1995176856
[biological and biochemical characterization of a new isolate of baboon papio papio endogenous type c virus].a new strain of baboon papio papio endogeneous type c virus was isolated from the testis of an animal of this species. the strain was characterized biochemically and biologically. it presents a host-range different from that of the prototype strain of the same virus.1977195750
nonhuman primates: laboratory animals of choice for neurophysiologic studies of sleep.a systematic study was made of several nonhuman primates to learn more about their relative usefulness for studies of sleep. species studied included the guinea baboon (papio papio), kenya or yellow baboon (p cynocephalus), olive baboon (p anubis), sacred baboon (p hamadryas), vervet monkey (cercopithecus aethiops), rhesus monkey (macaca mulatta), bonnet monkey (m radiata), crab-eating monkey (m fascicularis), patas monkey (erythrocebus patas), chimpanzee (pan troglodytes), mongoose lemur (lemur ...1977201798
the effect of acth and hcg on adrenal steroidogenesis in the neonatal baboon (papio papio). 1992206082
photosensitive epilepsy in papio papio as a model for drug studies.photically-induced epilepsy in papio papio provides a convenient model for assessing the efficacy and the acute neurological toxicity of new anticonvulsant drugs prior to clinical trial. its drug sensitivity is broadly comparable to that of generalized seizures in man. it also shares some specific properties with syndromes of reflex epilepsy in man.1978220003
effects of opiate-like peptides, morphine, and naloxone in the photosensitive baboon, papio papio.the effects of intracerebroventricular (i.c.v.) or systemic injections of met- or leu-enkephalin, beta-endorphin, fk 33.824 (d-ala2, mephe4, met(o5)-ol-enkephalin) and of morphine and naloxone have been studied in baboons, papio papio, which spontaneously show photically induced epileptic responses. animals were chronically implanted with epidural or deep recording electrodes and a cannula in one lateral ventricle, and tested whilst seated in a primate chair. in some animals the natural syndrome ...1979223724
a primate model for testing anticonvulsant drugs.senegalese baboons (papio papio), with a natural syndrome of photosensitive epilepsy, consistently show generalized myoclonic jerks if stimulated stroboscopically at hourly intervals, two to eight hours after the intravenous administration of allylglycine, 200 mg/kg. this provides a model for testing the acute antiepileptic effects of established or new drugs. the relationship between concentration of drug, antiepileptic action, and acute neurological toxic effects can be studied. pnehobarbital ...1975237498
mycobacterium bovis infection in baboons (papio papio).two tuberculin-positive baboons in a primate colony were found to have grossly visible tuberculous lesions in the liver, spleen, lung, and mediastinal lymph nodes on necropsy. results of histopathologic examination of the tissues showed granulomas with langhans giant cells. an acid-fast organism was isolated from tissues of each baboon; the isolates were identified as mycobacterium bovis by being negative for niacin production and nitrate reduction and by their susceptibility to thiophen-2-carb ...1977324436
seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms.laboratroy and clinical evidence indicates that tricyclic antidepressants lower seizure threshold and in high doses may induce generalised seizures. in baboons with photosensitive epilepsy (papio papio) the effects of 2 tricyclic antidepressants (imipramine and chlorimipramine) and of maprotiline and nomi fensine have been studied (i.v. dose range 1-20 mg/kg. imipramine, chlorimipramine and maprotiline (10 mg/kg i.v.) lowered seizure threshold to a comparable extent, whereas nomifensine (10 mg/k ...1977402667
[the sheath of scarpa ganglion cells in the baboon papio papio].the sheath of the bipolar perikarya of the vestibular ganglion (scarpa) in papio papio is made up of several schwann cells which concur to form loose myelin, and at most five layers of compact myelin. most of the schwann cytoplasmic layers stop at the emergence of both neurites, forming at the point an incomplete ranvier half-node. the constitution of the vestibular perikaryal sheath in papio is intermediate between those previously described in the rat and in the human.1977404837
proteoglycan populations of baboon (papio papio) articular cartilage.1. gel electrophoresis of proteoglycans extracted with use of 4 m-guanidinium chloride from baboon (papio papio) articular cartilage and purified on deae-cellulose in 8 m-urea yielded three bands on electrophoresis in polyacrylamide/agarose gels: two wide bands close together (i and ii) and a third, thinner and more rapidly moving band (iii). 2. gel electrophoresis of fractions from direct 'dissociative' gradients showed that these bands were partially separated (buoyant density of i greater tha ...1977405971
acute dystonia as an idiosyncratic response to neuroleptics in baboons.among 25 baboons, papio papio, 2 consistently showed acute dystonic reactions, with mouthing, compulsive gnawing and limb and trunk dystonia, following the intravenous administration of neuroleptics and related drugs (haloperidol, 0-6-1-2 mg/kg; pimozide 0-5-2-5 mg/kg; chlorpromazine 5-25 mg/kg; metoclopramide 1-5-1-7 mg/kg; oxyperomide 0-25-1-0 mg/kg). the syndrome was not seen after thioridazine (3-7 mg/kg). the dystonic responses occurred within 1-2 h of drug injection and lasted for 2-24 h. ...1977406964
a comparison of the effects of chronically administered diazepam and phenobarbital and learning in the papio papio model of epilepsy. 1977408818
influence of cortisone on seizure activity in the papio papio model of epilepsy. 1977408824
human pb, human post-pb, and nonhuman primate pb proteins: immunological and biochemical relationships.the isolation and characterization of a protein from human parotid saliva termed the "post-pb protein" is described. by several criteria, this protein is closely related to the human pb proteins. when reacted against antisera to human pb protein in double diffusion, the post-pb protein is found to be related to the pb proteins by lines of identity. however, when the partial n-terminal amino acid sequences of the post-pb protein and pb proteins are compare, the sequences are not identical. becaus ...1977412494
connections of latero-dorsal nucleus of the thalamus. ii. experimental study in papio papio.modifications of the latero-dorsal (l.d.) nucleus of the thalamus have been observed earlier in man in relation to limbic lesion of various etiologies. our proposal was to determine the role of l.d. in memory disturbances. we attempted to study the connections of l.d. in papio papio baboon after surgical lesion using silver impregnations as well as traditional techniques. we found three afferent pathways: from the fornix, the posterior cingulate and the parietal cortex (area 7). the most importa ...1977412567
increasing fetal adrenal formation of cortisol from pregnenolone during baboon (papio papio) gestation. 1977413590
mechanisms involved in mandibular condylopathy secondary to intraarticular injections of glucocorticoids.pharmacologic doses of triamcinolone hexacetonide were injected intramuscularly or intraarticularly in immature papio papio baboons. the mandibular condyle served as a model for histologic examinations concerning the effect of glucocorticoid hormone on cartilage and bone. biochemical examinations of blood and urine indicated the development of distinct hypophosphatemia, hypercalcemia followed by hyperphosphaturia, and hypocalciuria. serum alkaline phosphatase activity rose during the initial pha ...1978413894
[temporal variations of excitability in photosensitive papio papio after series of intermittent light flashes (author's transl)].after several trains of intermittent photic stimulation (ips) each lasting 10 seconds and sometimes inducing paroxysmal electrical activity, isolated flashes or salves of 2 or 3 light flashes are capable of inducing bifrontal paroxysmal discharges in photosensitive papio papio, an effect which is augmented by allylglycine or the use of highly photosensitive animals. use of these salves repeated every second enabled the authors to demonstrate two types of changes in cortical excitability after in ...2006417388
[the induction of seizures in "papio papio" following allylglycine alone or in combination with intermittent photic stimulation (author's transl)].allylglycine, an inhibitor of gaba synthesis, produces increased sensitivity to photic stimulation and in convulsant doses spontaneous seizures arising occipitally in the baboon (horton and meldrum, 1973). in this study, convulsant doses of allylglycine induced either sharp wave and polyspike frontorolandic discharges (fr) or critical posterior discharges which then reinforce the fronto-rolandic spikes. a seizure may then arise from the fronto-rolandic region and secondarily spread to the rest o ...2013594466
identification of 7xi-hydroxytetrahydrocortisol and 7xi-hydroxytetrahydrocortisone from urine of newborn baboons (papio papio).two highly polar, unconjugated metabolltes of tetrahydrocortisol and tetrahydrocortisone, which had been shown previously to account for greater than 40% of [14c]cortisol (f) administered to baboon neonates, were isolated from urine of a term newborn animal. metabolites were extracted with ethyl acetate, purified by sequential paper chromatography and crystallization, and identified by chemical and biochemical procedures. both metabolites of f are 5beta-pregnanes with a hydroxyl of unknown orien ...1978663983
[buccal candidiasis and intestinal invagination in captive baboons, papio papio]. 1978715290
polymorphism of the ca-i locus of carbonic anhydrase in baboon.polymorphism of erythrocytic carbonic anhydrase was studied by means of the usual technique of starch gel electrophoresis in papio papio, papio hamadryas, papio cynocephalus and papio anubis. in a sample containing both papio cynocephalus and papio anubis, examples of the homozygote ca-ib/ca-ib were found. a study of parental transmission established the ca-ib allelic form.1975804560
electroencephalographic effects of fenfluramine and norfenfluramine in the baboon, papio papio. 1975809780
effects of tetrahydrocannabinols on kindled amygdaloid seizures and photogenic seizures in senegalese baboons, papio papio.intraperitoneal injections of delta 8-tetrahydrocannabinol (thc) and delta 9-thc failed to affect myoclonic response to photic stimulation in senegalese baboons (papio papio). however, both isomers of thc exerted dose-related antiepileptic effects upon established kindled convulsions provoked by electrical stimulation of amygdala in the same species. delta 9-thc was more potent than delta 8-thc, in terms of both antiepileptic effects and general toxicity. the antiepileptic effects of the thc iso ...1975810346
biogenic amines and the photomyoclonic syndrome in the baboon, papio papio.the role of biogenic amines in the proclivity of the baboon, papio papio, to exhibit an epileptoid response to flashing light was studied. intraventricular injections of epinephrine and norepinephrine reduced or blocked the photomyoclonic syndrome without modifying ongoing behavior. epinephrine was effective at doses of 100 mg and more, and norepinephrine was effective at doses of 250 mg and more. neither intraventricular injections of as much as 1.5 mg of dopamine and 1.0 mg of serotonin nor ch ...1976812981
spontaneous recurrent seizure state induced by daily electric amygdaloid stimulation in senegalese baboons (papio papio).daily electrical stimulation of the amygdala in senegalese baboons (papio papio) resulted in the development of generalized convulsive seizures focal onset through five distinct clinical stages in an average of 72 days. the chronologic pattern of electroclinical features suggested that vertical intrahemispheric ictal dissemination was of primary importance in the progressive seizure development. some animals developed spontaneous recurrence of both partial complex and primary generalized seizure ...1976814482
[toporaphy of chromosome banding in papio papio].results are given of a study of chromosome banding patterns of papio papio. the 22 chromosomes are described and illustrated and their measurements are given.1976818939
serum progesterone in the pregnant baboon (papio papio). 1976819050
[frontal cerebral cortex and photic epilepsy of the baboon papio papio (author transl)].it was discovered in 1966 that the senegalese baboon (papio papio) exhibits a photosensitive epilepsy. this finding has led, among other work, to the neurophysiological study of this epilepsy. although in some characteristics the baboon's photosensitive epilepsy differs from that of man, it can be considered that this animal presents a real model of essential epilepsy, for the study of the human disease. 2. in the baboon, the eeg disturbances triggered by intermittent light stimulation at 25 hz ...1976819647
[spontaneous spikes-waves of anterior predominance with paroxysmal manifestations induced by intermittent photic stimulation in papio papio. reflections on a particular case]. 2004821109
[preliminary study of the ontogenesis of activities of the "pgo" spike type in papio papio]. 2003821113
[cerebellum and photosensitive epilepsy in papio papio: effects of cerebellar lesions on photosensitivity and visual evoked potentials]. 2004821114
modifications and development of spinal reflexes in the alert baboon (papio papio) following an unilateral vestibular neurotomy.unilateral vestibular neurotomy performed on 6 baboons was followed by the classical postural and locomotor postoperative disorders. postoperative spinal reflex excitability was studied in these awake baboons by measuring monosynaptic recruitment ratios in soleus motoneuronal pool and the recovery cycle of the monosynaptic response. vestibular neurotomy induces: (1) asymmetrical spinal reflexes with a decrease of the recruitment on the side of the section and an increase on the opposite side. (2 ...1976821586
measurement of anticonvulsant activity in the papio papio model of epilepsy.the status of papio papio as a model of clinical epilepsy has been reviewed. the anticonvulsant effects of single doses of various classic and experimental agents have been compared against seizures induced in the p. papio by intermittent light stimulation. long-acting but not short-acting barbiturates have been shown fully to control seizures with minor sedative effects. diphenylhydantoin (in chronic doses only) and trimethadione are often effective but not consistently so. diazepam and clonaze ...1976821787
[experimental study of the cerebrovascular effects of sodium nitroprusside in the baboon papio papio. its action on the experimental vasospasm].sodium nitroprusside (snp) has been suggested as hypotensive agent in the surgery of cerebral aneurysms. as a preliminary step to neurosurgery, a study of its cerebro-vascular and eeg action had been carried out in 42 papio-papio baboons. on the unanaesthetized analgesic-free animal, doses below 20 mumg/kg/min. induce only a moderate decrease of mean arterial blood pressure (mabp), a slight rise of intracranial pressure (icp) and a neat fall of cerebro-vascular resistance (cvr) without eeg modif ...1976822367
cone-rod dystrophy in the guinea baboon.three stages of macular degeneration associated with diffuse cone-rod dystrophy have been described in a guinea baboon (p papio) colony. clinically, the affected animals displayed abnormal behavior associated with decreased vision. ophthalmoscopically, the lesion in the macula was the only change observable in early cases; retinal vessel attenuation and optic disc pallor were seen only in the advanced cases. the hyperfluorescence of the maculae was the result of loss of pigment in the pigmented ...2008822562
inhibition of reflex epilepsy by (+/-)-n-n-propylnorapomorphine.in baboons, papio papio, spontaneously showing photosensitive epilepsy, myoclonic responses to intermittent photic stimulation were reduced or abolished for up to four hours by (+/-)-n-n-propylnorapomorphine (npa) 0.05-0.2 mg/kg body weight, given i.v. in animals pretreated with allyglycine, 200 mg/kg, a transient abolition of myoclonic responses followed npa, 0.2 mg/kg. in dba/2 mice, seizures following auditory stimulation were attenuated or abolished by npa 0.025-0.1 mg/kg given intraperitone ...1976824145
[differences in distribution of type i and type ii collagens in the superficial and intermediary zones of articular cartilage].undecalcified frozen sections, 40 mu thick, were cut from the knee articular cartilage of young adult baboons (papio papio). the sections were freeze dried and the superficial and the intermediate zones were separated by microdissection under a binocular dissecting microscope. the material of each zone was cleaved with cnbr and the major peptides were analyzed by discelectrophoresis in sds polyacrylamide. peptides alpha, cb 3,5 and alpha, (ii) cb 10 were used as characteristic markers for type i ...1976825275
metabolic clearance and production rates of progesterone in non-pregnant and pregnant baboons (papio papio).the metabolic clearance rate (mcr) of progesterone was examined in the baboon to determine whether the increased serum progesterone concentrations during gestation result from increased production or decreased clearance. mcr was determined by constant infusion of [3h]progesterone in 6 non-pregnant baboons and 13 pregnant animals, between 58 and 175 days gestation. progesterone mcr (mean+/-se) was significantly greater in pregnant (1316+/-105 1/day, p less than 0.025; 87.3 +/- 6.2 1/day/kg, p les ...1976825366
the identification of 3alpha,6beta,11beta,17,21-pentahydroxy-5beta-pregnan-20-one (6beta-hydroxy-thf)--the major urinary steroid of the baboon (papio papio). 1976827658
the relationship between the anticonvulsant properties of sc-13504 and its plasma levels, measured by polarography, in baboons with photosensitive epilepsy.sc-13504 was given intravenously to baboons with photosensitive epilepsy, papio papio, with and without prior administration of allylglycine. plasma levels of the drug were determined by differential pulse polarography and correlated with behavioural changes and the anticonvulsant action of the drug. protection against photically induced seizures or self-sustaining myoclonic responses was seen 30 to 120 min after sc-13504, 4-8 mg/kg (when plasma levels were 1 mug/ml or greater). eeg and neurolog ...1976827776
effect of nomifensine on brain amines and epilepsy in photosensitive baboons.1. the literature, both clinical and experimental, suggests that tricyclic antidepressants are potentially epileptogenic. using the experimental model of epilepsy provided by the photosensitive baboon, papio papio, the epileptic potential of four antidepressant drugs, two of which are tricyclic, has been assessed. the drugs used were imipramine 1, 10 and 20 mg/kg, chlorimipramine 1, 10 and 20 mg/kg, maprotiline 1 and 10 mg/kg and nomifensine 10 and 20 mg/kg. in a second series of experiments the ...1977911646
the metabolism of cortisol by term baboon neonates (papio papio).the metabolism of iv administered (4-14c)cortisol (f) was examined in 3 female, spontaneously delivered, term baboons less than 24th old. sixty and 80% of 14c was recovered in urine within 24 and 68 h,respectively. the distribution of urinary 14c was 44.7% unconjugated, 18.1% glucuronoside, 3.3% sulfate, and 24% unextractable with ethyl acetate. the metabolites were isolated by chromatography and crystallization. eight per cent of unconjugated and 60% of glucuronoside metabolites were more polar ...1976954646
the metabolic clearance rates and interconversion of cortisol and cortisone in pregnant and nonpregnant baboons.pregnancy alters the pattern of maternal cortisol (f) metabolism and increases the maternal serum cortisol-binding capacity (cbc) of baboons. to determine whether these changes are associated with alterations in f clearance,the metabolic clearance rate (mcr) and interconversion (p) of f and cortisone (e) were measured by continuous infusion of (3h)f and (14c)e in 9 regularly menstruating and 7 pregnant baboons (papio papio). in nonpregnant animals, the values (x +/- se) for mcr-e (488 +/- 48 1/d ...1976954656
effects of drugs modifying brain levels of catecholamines on photically induced epilepsy in papio papio.the behavioral and electrographic effects of dl-amphetamine, disulfiram, fla-63, and propranolol on the photically induced epilepsy of the senegalese baboon were evaluated. amphetamine produced somatic hypokinesia with enhancement of eye movements, diminution of spontaneous paroxysmal activity, and little change in photosensitivity. the acute effects of disulfiram and fla-63 were poor, but the latter was lethal in the days following administration. propranolol showed no consistent effects. parti ...1976976217
[paroxysmal eeg and emg discharges induced by intermittent photic stimulation in the photosensitive papio papio]. 20041035432
neurophysiology of photically induced epilepsy in papio papio.this chapter critically reviews arguments supporting the role of the frontal cortex in light-sensitive epilepsy of the baboon papio papio in the light of the most recent neurophysiological research. in particular, it is known that spontaneous or ils-induced paroxysmal discharges, as well as generalized seizures, originate in the frontorolandic cortical region. in this region during ils, neurons behave in the same manner as hyperexcitable neurons in focal epileptogenic lesions of animals and man. ...19751146641
excessive light sensitivity in papio papio: its variation with age, sex, and geographic origin.excessive sensitivity (levels 3 and 4) in a population of 1,122 papio papio was related with age, sex, and geographical origin. (1) age. there was no clinical response to intermittent light stimulation under the age of 5 months. these was no difference between animals 6 months to 2 years (j1) and those aged 2 to 4 years (j2). adult females were less often light sensitive (levels 3 and 4 = 32.9%) than immature females (52.4%). adult males could usually not be tested, but were probably less often ...19751149713
drugs modifying dopaminergic activity and behaviour, the eeg and epilepsy in papio papio.acute changes in spontaneous motor activity, the eeg and photically induced epileptic responses have been observed in baboons (papio papio) following the i.v. injection of drugs acting on dopaminergic transmission. apomorphine hydrochloride, 0.5-1.0 mg/kg, produced a phase of acute excitement with accentuated vigilance and abnormal buccal motor activity lasting 30-40 min; during this phase myoclonic responses to intermittent photic stimulation were absent. after piribedil (et 495, 1,2'' -pyrimid ...19911149807
photically induced epilepsy in papio papio as a model for drug studies.neurophysiological studies employing drugs have been undertaken in the natural syndrome of photically induced epilepsy in the senegalese baboon papio papio. gaba-mediated inhibition, both pre- and posysynaptic, plays an important role in the epileptic manifestations seen in this syndrome synapses can significantly modify photically induced epileptic responses, partly as a result of changes in afferent activity. the level of activity in dopaminergic systems can also modify the epileptic signs. am ...19751170711
recurrent spontaneous seizure state induced by prefrontal kindling in senegalese baboons, papio papio.in our earlier study of amygdaloid kindling in papio papio (pp), the development of partial complex seizure and of focal motor seizure was correlated with bifrontal theta discharge and increasing rolandic spike discharge respectively and the final stage was characterized by primary generalized convulsive seizure. since the latter seizure pattern is known to originate from the frontal focus in man, the frontal cortex became suspect in the development of the final stage seizure pattern. daily pref ...19751201534
the effects of ampa receptor antagonists on kindled seizures and on reflex epilepsy in rodents and primates.two potent glutamate antagonists, nbqx and gyki 52466, that act selectively on non-nmda receptors, have been tested for anticonvulsant activity in 3 models of reflex epilepsy (sound-induced seizures in dba/2 mice and in genetically epilepsy-prone rats and photically-induced myoclonus in papio papio) and in amygdala kindled rats. both compounds potently but transiently suppress reflexly-induced epileptic responses. gyki 52466 also reduces behavioral seizures and afterdischarge duration in amygdal ...19921337444
serotoninergic, noradrenergic, and peptidergic innervation of onuf's nucleus of normal and transected spinal cords of baboons (papio papio).we have investigated with light and electron microscope immunocytochemistry the aminergic and peptidergic innervation of onuf's nucleus in adult baboons. this nucleus, located in the ventrolateral part of the sacral spinal cord (s2 and s3), is considered to control urethral and anal sphincters and penile muscles. by comparison of intact and transected spinal cords, we have found that serotoninergic innervation has two origins: first, supraspinal, innervating the whole nucleus, with a possible pr ...19921374763
in vitro dissolution of uranium oxide by baboon alveolar macrophages.in vitro cellular dissolution tests for insoluble forms of uranium oxide are technically difficult with conventional methodology using adherent alveolar macrophages. the limited number of cells per flask and the slow dissolution rate in a large volume of nutritive medium are obvious restricting factors. macrophages in suspension cannot be substituted because they represent different and poorly reproducible functional subtypes with regard to activation and enzyme secretion. preliminary results on ...19921396447
anticonvulsant profile of mdl 27,266: an orally active, broad-spectrum anticonvulsant agent.the novel anticonvulsant substance mdl 27,266 was tested in a variety of anticonvulsant models to assess its anticonvulsant profile, behavioral toxicity and oral bioavailability. intraperitoneally (i.p.) administered mdl 27,266 afforded complete protection against sound-induced seizures in dba/2j and frings audiogenic-seizure (ags)-susceptible mice (ed50s: 5.0 and 5.1 mg/kg, respectively). it was also effective following i.p. administration to cf#1 mice against maximal electroshock (mes)-, pente ...19921396547
magnetic resonance imaging to monitor pathology of caudate-putamen after excitotoxin-induced neuronal loss in the nonhuman primate brain.we used mr imaging to locate and monitor in vivo the pathological events taking place 2 to 4 weeks after unilateral striatal injections of ibotenic acid (ia) in the papio papio baboon. as early as 2 weeks after ia injections, excitotoxic lesions in the caudate and the putamen were directly visualized on t1-weighted images as small areas of low signal intensity. on t2-weighted images, the lesion sites were visualized as areas of high-intensity signal, spreading over larger areas than the correspo ...19921397172
longitudinal effect of tiludronate on bone mineral density, resonant frequency, and strength in monkeys.the effect of tiludronate on bone was studied in 72 growing monkeys (papio papio), 36 males and 36 females, aged 4-7 years. they were randomly allocated into four groups (18 animals per group, 9 males and 9 females): group i, controls; group ii, 10 mg/kg/day; group iii, 20 mg/kg/day; and group iv, 40 mg/kg/day of tiludronate. a total of 12 animals (6 males and 6 females) in each group were sacrificed at the end of treatment (1 year) and 6 animals (3 males and 3 females) per group 1 year later. b ...19921414478
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