| eimeria falciformis (eimer, 1870) in specific pathogen free and gnotobiotic mice. | the endogenous and exogenous stages of a species of murine eimeria were examined and compared with descriptions of other species isolated from mus musculus. developing stages of the parasite were found in the epithelial cells of the caecum and colon. three asexual generations were observed, the third becoming apparent on the fourth day concurrently with gametogeny. the total length of the prepatent period was 5 days. oocysts of the coccidian, identified as eimeria falciformis, were administered ... | 1975 | 127155 |
| eimeria falciformis: effects of 60co irradiation on infectivity and immunogenicity of sporulated oocysts. | | 1977 | 915624 |
| effects of in vivo t-cell depletion on immunity to eimeria falciformis. | | 1991 | 2004834 |
| possible mode of action of toltrazuril: studies on two eimeria species and mammalian and ascaris suum enzymes. | the anticoccidial properties of toltrazuril in eimeria falciformis-infected mice were potentiated by the simultaneous application of pyrimethamine, trimethoprim, or sulfadimidine. the same drugs potentiate the effect of toltrazuril by killing e. tenella schizonts in chicken kidney-cell cultures. activities of some enzymes of the respiratory chain, such as succinate-cytochrome c reductase and nadh oxidase and succinate oxidase from mouse liver, were reduced in the presence of toltrazuril. the sam ... | 1989 | 2560189 |
| in vitro interactions between murine macrophages and eimeria falciformis sporozoites. | a short-term (2 h) assay was used to investigate the in vitro fate of eimeria falciformis sporozoites in murine peritoneal macrophages. in minimal medium, uptake of sporozoites was low by both normal (naive) and immune macrophages. however, when heat-inactivated serum from immune mice was added to the incubation medium, sporozoite uptake was much more efficient. sporozoite lysis was observed only in immune macrophages and required both antibodies and complement. pretreatment of immune macrophage ... | 1989 | 2595081 |
| [subpellicular microtubules in the meroxoites of eimeria falciformis (coccidia, sporozoa)]. | | 1972 | 4346784 |
| [ultrastructure of schizonts and merozonts of the murine coccidium eimeria falciformis]. | | 1971 | 5152848 |
| immediate type hypersensitivity in murine coccidiosis. | subcutaneous injection of soluble merozoite antigen into the footpad of mice previously infected with eimeria falciformis caused an immediate type hypersensitivity as measured by footpad swelling (fps). this reaction was first demonstrable ten days after the infection. maximal values were achieved on day 13, and later on the intensity of fps decreased. increase in the dose of oocysts or in the number of infections did not enhance the degree of fps. the reaction was transferable to normal recipie ... | 1984 | 6532024 |
| differentiation of sarcocystis neurona from eight related coccidia by random amplified polymorphic dna assay. | four isolates of sarcocystis neurona from horses with equine protozoal myeloencephalitis and eight species of coccidia from the genera sarcocystis, toxoplasma or eimeria were differentiated using the random amplified polymorphic dna assay. a single, common, 550-bp dna fragment was amplified from the dna of each s. neurona isolate using a 16-nucleotide primer. crosshybridization analyses among s. neurona isolates showed that dna fragments had at least partial sequence homology. the primer generat ... | 1994 | 7877630 |
| production and characterization of monoclonal antibodies directed against eimeria falciformis and cross-reactive with sporozoites from two species of avian coccidia. | monoclonal antibodies (mabs) were obtained against the surface antigens of the eimeria falciformis sporozoite by immunizing mice with whole homogenized sporozoite. the hybridomas were selected by their reactivities against oocyst extracts, then against glutaraldehyde-treated sporozoites. three mabs recognized both the surface of e. falciformis, e. tenella, and e. acervulina and their refractile bodies, whereas a fourth mab recognized only one epitope on the refractile bodies. all mabs bound to t ... | 1994 | 7971926 |
| coccidia parasitism increases resistance of mice to subcutaneous inoculation with salmonella abortus ovis. | resistance of outbred mice to subcutaneous challenge with s. abortus ovis was increased when previously or simultaneously parasitized with eimeria falciformis. this was measured by mortality rates and levels of splenic infection induced by salmonella in parasitized and control nmri or cd-1 (cr) mice. no effect was observed when e. falciformis was inoculated after s. abortus ovis. | 1981 | 7342834 |
| scanning electron microscopy of merogonous stages of eimeria falciformis var. pragensis in mus musculus. | asexual stages of eimeria falciformis var. pragensis in swiss-webster mice were studied by scanning electron microscopy. sporozoites were present in the cecum and colon 2 h post-inoculation (pi) and measured 11.3 x 2.1 micrometer (9-13.9 x 2-2.2 micrometer). sporozoites penetrated epithelial cells with an extended anterior end and were constricted at the site of entry. asexual generations were found in the cecum and colon epithelial cells. in meronts found at days 3-9 pi, merozoites matured sync ... | 1981 | 7324544 |
| eimeria falciformis - merozoites with refractile bodies. | | 1981 | 7245842 |
| sensitivity and specificity of the indirect fluorescent antibody test in the study of four murine coccidia. | the sensitivity and specificity of the indirect fluorescent antibody (ifa) test for the detection of serum antibodies were examined in mice that were infected with eimeria falciformis, e. ferrisi, e. papillata, or e. vermiformis. for the study of each species, five groups of mice were given graded inoculation doses of 10, 10(2), 10(3), 10(4), or 10(5) sporulated oocysts in a primary infection. the sixth group was infected with three sequential doses of 1.5 x 10(3), 1.5 x 10(4), and 1.5 x 10(5) s ... | 1982 | 7045347 |
| effects of nylon wool purification on infectivity and antigenicity of eimeria falciformis sporozoites and merozoites. | | 1984 | 6502364 |
| [electron microscopy studies on the development of microgametes of the mouse coccidium eimeria falciformis]. | | 1973 | 4750664 |
| [the fine structure of the macrogamete of the mouse coccidium eimeria falciformis]. | | 1971 | 4327671 |
| effects of intestinal contents from normal and immunized mice on sporozoites of eimeria falciformis. | the interaction of eimeria falciformis sporozoites with the intestinal epithelium and with the intestinal contents from the cecum and colon of normal and specifically immunized mice was studied by light (lm) and scanning electron (sem) microscopy. fecal (fm) and enterocyte-associated (eam) mucus were removed from the cecum and colon of normal mice and mice that had been immunized 1, 6, 12, or 20 days earlier with a series of oral inoculations of e. falciformis oocysts. sporozoite-specific iga, b ... | 1985 | 3989746 |
| mouse strain variation and effects of oocyst dose in infection of mice with eimeria falciformis, a coccidian parasite of the large intestine. | | 1985 | 3875572 |
| application of chemi- and bioluminescence in studies of immunological reactions against protozoa. | the opsonization and lysis of different protozoa by antibodies and/or complement was followed using luminol-dependent chemiluminescence and bioluminescence. the addition of immune serum to variable antigen type populations of trypanosoma evansi led to the specific opsonization of trypanosomes resulting in an intense metabolic activation and chemiluminescence response of phagocytic cells. in comparison to those of uninfected control mice, the phagocytosis of coccidia merozoites by spleen cells fr ... | 1986 | 3705427 |
| [effect of eimeria falciformis infection on the development of toxoplasmosis in mice]. | white mice previously infected with 10(2), 10(3) or 10(4) eimeria falciformis oocysts on days 0, 5, 10 or 30 were inoculated per os with 10(1), 10(2), 10(3) or 10(4) toxoplasma oocysts. while the results obtained for mice with higher toxoplasma inocula were consistent, animals with 10(1) and 10(2) oocysts previous inoculation with eimeria showed important differences related with those infected only with toxoplasma. for example, survival time was higher in animals infected with both parasites, e ... | 1986 | 3671805 |
| murine major histocompatibility complex and immune response to eimeria falciformis. | the genetics of the immune response to eimeria falciformis were investigated in three inbred and six congenic strains of mice. there were significant differences among strains in oocyst production and age-related mortality from parasitic infection. genes within the h-2 complex and also non-h-2 genes share in the immune response to eimerian infection. | 1988 | 3335404 |
| b-lymphocyte responses in the large intestine and mesenteric lymph nodes of mice infected with eimeria falciformis (apicomplexa). | b-cell responses of 3 immunoglobulin isotypes (iga, igg, and igm) were investigated in the large intestine and mesenteric lymph nodes (mln) of naive or immune mice after inoculation of oocysts of eimeria falciformis. primary and anamnestic iga and igg lymphocyte responses to e. falciformis occurred in the large intestine of nonimmune and immune mice, respectively. iga-containing lymphocytes (igac) were the largest population of responding b cells in the large intestine. in infected mice, igac ac ... | 1988 | 2965760 |
| kinetics of murine delayed-type hypersensitivity response to eimeria falciformis (apicomplexa: eimeriidae). | mice recovering from a primary infection with an intestinal protozoan parasite, eimeria falciformis (apicomplexa: eimeriidae), showed a classic delayed-type hypersensitivity (dth) reaction to oocyst antigen challenge. this reaction was characterized by a biphasic pattern of footpad swelling. the first swelling peaked at 2 h after antigen challenge, whereas the second swelling peaked at 24 to 48 h after challenge. the dth reaction was transferable with a t-cell-enriched spleen cell population fro ... | 1989 | 2521213 |
| apicomplexan parasite, eimeria falciformis, co-opts host tryptophan catabolism for life cycle progression in mouse. | the obligate intracellular apicomplexan parasites, e.g. toxoplasma gondii and plasmodium species, induce an ifnγ-driven induction of host indoleamine 2,3-dioxygenase (ido), the first and rate-limiting enzyme of tryptophan catabolism in the kynurenine pathway. induction of ido1 supposedly depletes cellular levels of tryptophan in host cells, which is proposed to inhibit the in vitro growth of auxotrophic pathogens. in vivo function of ido during infections, however, is not clear, let alone contro ... | 2012 | 22535959 |
| genome mining offers a new starting point for parasitology research. | parasites including helminthes, protozoa, and medical arthropod vectors are a major cause of global infectious diseases, affecting one-sixth of the world's population, which are responsible for enormous levels of morbidity and mortality important and remain impediments to economic development especially in tropical countries. prevalent drug resistance, lack of highly effective and practical vaccines, as well as specific and sensitive diagnostic markers are proving to be challenging problems in p ... | 2015 | 25563615 |
| [vaccination of mice against murine coccidiosis by ingestion of surface proteins of eimeria falciformis incorporated in liposomes]. | proteins are released from the surface of sporozoites of eimeria falciformis during their in vitro incubation in a detergent solution. some of these proteins reacted with antibodies from infected mice and specifically stimulated the proliferation of mesenteric lymph node cells of these mice. oral immunization of mice with liposome encapsulated sporozoite surface antigens protected mice against a challenge infection. two proteins (m.w. 27 and 180 k) induced an antibody synthesis in these vaccinat ... | 1989 | 2500226 |
| effect of in vivo t-cell depletion on the effector t-cell function of immunity to eimeria falciformis. | balb/c mice were exposed to the enteric parasite eimeria falciformis to produce a natural acquired immunity. the mice were then depleted of their effector t-cell function by in vivo administration of a cytotoxic thy-1.2 mouse monoclonal antibody. t-cell depletion was demonstrated by a reduction in concanavalin a-induced proliferation of splenic lymphocytes in treated mice compared with that in controls. twenty-four hours following t-cell depletion, the mice were challenged with 5,000 oocysts of ... | 1990 | 1971253 |
| [morphobiology and pathogenicity of eimeria falciformis var. pragensis cerna, seraud, mehlhorn & scholtyseck, 1974 in mouse (mus musculus)]. | the life cycle of a species of murine eimeria, isolated from a commercial source of mice is described using experimental infections. a pure strain was established starting from a single oocyst administered to eimeria-free swiss white mice. the prepatent period was 6 1/2 to 7 days, and the patent period lasted 6 to 10 days. oocysts were subspherical or ovoid, with a smooth double-layered colourless membrane. micropila was absent. the sporulated oocysts measured 15.7-25.1 x 14.1-22.0 microns (x780 ... | 1991 | 1844103 |
| in vitro interactions between murine neutrophils and eimeria falciformis sporozoites. | the in vitro interactions between elicited mouse peritoneal neutrophils, antibodies and newly excysted sporozoites of eimeria falciformis resulted in lysis of the parasite. this lysis required the presence of a heat-labile component of normal mouse serum, and was antibody- and cell-concentration-dependent. under optimal conditions (serum dilution = 1/192, effector cell/sporozoite = 10/1) this lysis, which began after incubation at 37 degrees c for 4 h, was nearly complete after 18 h. it began by ... | 1992 | 1337796 |
| [epidemiology of toxoplasmosis in costa rica: the importance of domestic rodents]. | a positive dye test for toxoplasma antibodies was observed in 5% of 100 mice (mus musculus) and 30.4% of 23 rats (rattus norvegicus and r. rattus). the parasite was isolated from two mice. the animals were captured in several urban localities in the metropolitan area of san josé, costa rica. the number of positive animals found appears to be enough to infect cats, whose principal source of infections are the toxoplasma cysts in the rodents. therefore it is apparent that domestic mice and rats, b ... | 1978 | 751107 |
| the pathological changes caused by eimeria falciformis var pragensis in mice. | groups of swiss white mice weighing 25-28 grams were infected orally with 500, 2,000, 5,000 or 20,000 oocysts of eimeria falciformis var pragensis. depression, anorexia, weight loss, diarrhea or dysentery, and dehydration were most pronounced at eight to ten days postinfection. the highest mortality, 31%, occurred in mice infected with 20,000 oocysts. none of the mice infected with 500 oocysts died. the pathological findings were equally severe in mice infected with 5,000 and 20,000 oocysts. the ... | 1978 | 743602 |
| the life cycle of eimeria falciformis var. pragensis (sporozoa: coccidia) in the mouse, mus musculus. | the life cycle of eimeria falciformis var. pragensis, established from a single oocyst, is described in experimentally infected mice (mus musculus). the coccidium had a prepatent period of 7 days and a patent period of 10--16 days. oocysts were spherical to ellipsoidal in shape and measured 21.2 x 18.3 micron. sporulation time was 3 to 3.5 days. sporocysts measured 12.2 x 7.2 micron and contained a circular to avoid granular sporocyst residuum measuring 5.5 x 5.0 micron. one, 2 or 3 circular to ... | 1978 | 567249 |
| migration of sporozoites of eimeria falciformis var pragensis from the absorptive to the crypt epithelium of the colon. | | 1979 | 480082 |
| effects of acquired resistance on infection with eimeria falciformis var. pragensis in mice. | mice immunized with infections of 500, 5,000, or 20,000 oocysts of e. falciformis var. pragensis were reinfected with 20,000 and 100,000 oocysts at 20 and 38 days, respectively, after the initial infection. after the first challenge infection, none of the immunized mice showed clinical signs of coccidiosis; a few mice passed very low numbers of oocysts, and oocyst discharge seemed to correlate negatively with immunizing dose. none of the mice immunized twice passed oocysts after challenge. mice ... | 1979 | 422230 |
| thymic dependence of immunity to eimeria falciformis var. pragensis in mice. | athymic (nude) mice, their normal littermates, and swiss white mice were infected with 750 oocysts of eimeria falciformis var. pragensis and reinfected twice with 20,000 oocysts, 20 and 40 days after the primary infection. the prepatent and patent periods of the primary infection were similar in each group of mice; however, the athymic mice discharged more oocysts. the normal littermates and swiss white mice developed immunity to the parasite after the first or second infection, whereas the athy ... | 1979 | 311346 |
| immune responses and protective effect in mice vaccinated orally with surface sporozoite protein of eimeria falciformis in iscoms. | immunostimulating complexes (iscoms) were built after treatment of a purified surface protein from eimeria falciformis sporozoites with a palmitic acid derivation, leading to a high ratio (33-64%) of p27 incorporation in these cage-like structures. p27 kept its antigenicity after incorporation in iscoms, which induced, after iterative intubations by the oral route to groups of mice, a systemic igg response, a local iga response, and a local enhanced cellular response as demonstrated by lymphopro ... | 1994 | 7975858 |
| cloning and characterization of an eimeria acervulina sporozoite gene homologous to aspartyl proteinases. | a lambda zapii cdna library was constructed using mrna from eimeria acervulina sporulated oocysts and screened with monoclonal antibodies raised against eimeria tenella sporulated oocytes. monoclonal antibody n3c8b12 identified a clone (6s2) potentially encoding an aspartyl proteinase since significant homology with cathepsin d, pepsin and renin proteinases was revealed by sequence comparisons. the 1500-bp cdna fragment containing the coccidial gene was subcloned into pgex-fa expression vector, ... | 1993 | 8139622 |
| the immunodominant eimeria acervulina sporozoite antigen previously described as p160/p240 is a 19-kilodalton antigen present in several eimeria species. | a lambda zap ii cdna expression library, constructed from eimeria acervulina (papa46 strain) sporulated oocyst stage, was screened with sera raised to e. acervulina or eimeria tenella oocysts in order to isolate clones coding for antigens common to the two species. most of the clones isolated were derived from the same gene. antisera raised to a recombinant glutathione-s-transferase fusion protein 1p reacted with an antigen of 19 kda in immunoblot of e. acervulina sporulated and unsporulated ooc ... | 1994 | 8183325 |
| comparison of four murine eimeria species in immunocompetent and immunodeficient mice. | factors associated with immune-mediated protection against coccidial parasites were examined in a series of experiments utilizing immunocompromised scid/scid(scid) and scid/scid.beige/beige(scid/bg) mice, as well as immunocompetent balb/c mice. number of oocysts produced per g feces each day and prepatent and patent periods were assessed for 4 eimerian parasites (eimeria papillata, eimeria vermiformis, eimeria falciformis, and eimeria ferrisi) using the 3 murine strains. the number of infections ... | 1996 | 8604093 |
| purification of a leucine aminopeptidase from eimeria falciformis. | a leucine aminopeptidase was purified from the oocysts of eimeria falciformis using affinity chromatography and gel filtration techniques. it had a molecular weight of 45-50 kda. its maximal activity against leucyl-p-nitro anilide was at ph 8.6. it is a metallo-enzyme highly inhibited by bestatin. | 1998 | 9559525 |
| cross-reactions between eimeria falciformis and eimeria pragensis in mice induced by trickle infections. | we describe a laboratory model using eimeria falciformis and e. pragensis to investigate some of the interactions in double-species infections of eimeria. mice were given trickle infections by oral inoculation of 100 sporulated oocysts of one species at 3 or 4 day intervals throughout the experiments and, once immunity had developed, as indicated by cessation of oocyst production, the animals were challenged with a single inoculation of the other species. a trickle infection of e. falciformis ga ... | 1998 | 9836310 |
| molecular phylogeny of the other tissue coccidia: lankesterella and caryospora. | nearly complete sequences were obtained from the 18s rdna genes of eimeria falciformis (the type species of the genus), caryospora bigenetica, and lankesterella minima. two clones of the rdna gene from c. higenetica varied slightly in primary structure. parsimony-based and maximum likelihood phylogenetic reconstructions with a number of other apicomplexan taxa support 2 major clades within the eucoccidiorida, i.e., the isosporoid coccidia (consisting of toxoplasma, neospora, isospora [in part], ... | 2001 | 11227876 |
| phylogenetic relationships among rodent eimeria species determined by plastid orf470 and nuclear 18s rdna sequences. | phylogenetic analyses for 10 rodent eimeria species from different host genera based on plastid orf470 and nuclear 18s rdna sequences were done to infer the evolutionary relationships of these rodent eimeria species and their correlation to morphology and host specificity. the phylogenies based on both data sets clearly grouped the 10 rodent eimeria species into two major lineages, which reflect more their morphological differences than host specificity. species in lineage a have spheroidal to s ... | 2001 | 11336753 |
| a common oocyst surface antigen of cryptosporidium recognized by monoclonal antibodies. | two hybridoma clones, cmyl3 and cmyl30, were generated by immunizing balb/c mice with excysted oocysts of cryptosporidium muris. both clones secreted monoclonal antibodies against an oocyst-wall antigen with apparent molecular mass of 250 kda (called cm250) from c. muris and c. parvum. the epitope appeared to be periodate-sensitive, suggesting the involvement of a carbohydrate moiety. immunofluorescence and confocal microscopy on purified oocysts and infected mouse tissues revealed staining conf ... | 2002 | 12049457 |
| early events in the life cycle of the mouse coccidium eimeria falciformis (eimer, 1870) schneider, 1875 in naive and immune hosts. | the initial phases of invasion of mammalian coccidia of the genus eimeria into host tissue are still poorly known. this process, including the passage of oocysts through the intestinal lumen, excystation of sporozoites, their penetration into epithelial cells and migration to the target site was studied in both naive and immune mice infected with eimeria falciformis. after oral infection, the intact oocysts were transported with enteral contents to the large intestine, where the excystation of s ... | 2004 | 15490760 |
| treatment of mice with the anticoccidial drug toltrazuril does not interfere with the development of a specific cellular intestinal immune response to eimeria falciformis. | immunity against eimeria-infections is highly specific and it depends on cell-mediated effector mechanisms. infections of balb/c mice with 1,000 sporulated oocysts of eimeria falciformis led to protection against challenge infections. treatment with the anti-coccidium toltrazuril, during primary infection, terminated the ongoing disease and did not interfere with the establishment of protective immunity against challenge infections. mesenteric lymph node cells of infected, treated as well as non ... | 2005 | 16163562 |
| cd8+ cells protect mice against reinfection with the intestinal parasite eimeria falciformis. | we investigated cellular immune responses of mice infected with the apicomplexan parasite eimeria falciformis in order to characterise protective immune mechanisms and effector functions. adoptive transfer experiments with mesenterial lymph node cells (mlnc) from immune donor mice were performed, and the oocyst output monitored after challenge infection. phenotypical analysis by fluorescence cytometry and t cell proliferation assay showed that already from day four post infection e. falciformis- ... | 2010 | 20034589 |
| a matter of timing: early, not chronic phase intestinal nematode infection restrains control of a concurrent enteric protozoan infection. | infections with parasitic worms are often long lasting and associated with modulated immune responses. we analyzed the influence of the nematode heligmosomoides polygyrus bakeri dwelling in the small intestine on concurrent protozoan infection with eimeria falciformis residing in the cecum. to dissect the effects of a nematode infection in the early versus chronic phase, we infected animals with e. falciformis 6 or 28 days post h. p. bakeri infection. only a concurrent early nematode infection l ... | 2010 | 20809519 |
| new insights into the excystation process and oocyst morphology of rodent eimeria species. | in this study, the mechanism of excystation of the rodent parasites eimeria nieschulzi, from rats, and eimeria falciformis, from mice, was investigated. in vitro, oocysts of both species are susceptible to the protease pepsin, and sporocysts and sporozoites can be excysted in a similar way. scanning electron microscopy (sem) revealed a collapse of the oocysts wall at both polar ends after pepsin treatment. this occurs without any visible damage of the outer wall. using fluorescence and transmiss ... | 2011 | 21498113 |
| eimeria genomics: where are we now and where are we going? | the evolution of sequencing technologies, from sanger to next generation (ngs) and now the emerging third generation, has prompted a radical frameshift moving genomics from the specialist to the mainstream. for parasitology, genomics has moved fastest for the protozoa with sequence assemblies becoming available for multiple genera including babesia, cryptosporidium, eimeria, giardia, leishmania, neospora, plasmodium, theileria, toxoplasma and trypanosoma. progress has commonly been slower for pa ... | 2015 | 25986325 |
| the genome of eimeria falciformis--reduction and specialization in a single host apicomplexan parasite. | the phylum apicomplexa comprises important unicellular human parasites such as toxoplasma and plasmodium. eimeria is the largest and most diverse genus of apicomplexan parasites and some species of the genus are the causative agent of coccidiosis, a disease economically devastating in poultry. we report a complete genome sequence of the mouse parasite eimeria falciformis. we assembled and annotated the genome sequence to study host-parasite interactions in this understudied genus in a model orga ... | 2014 | 25142335 |
| eimeria falciformis infection of the mouse caecum identifies opposing roles of ifnγ-regulated host pathways for the parasite development. | intracellular parasites reprogram host functions for their survival and reproduction. the extent and relevance of parasite-mediated host responses in vivo remains poorly studied, however. we utilized eimeria falciformis, a parasite infecting the mouse intestinal epithelium, to identify and validate host determinants of parasite infection. most prominent mouse genes induced during the onset of asexual and sexual growth of parasite comprise interferon γ (ifnγ)-regulated factors, e.g., immunity-rel ... | 2014 | 24368565 |
| il-22 mediates host defense against an intestinal intracellular parasite in the absence of ifn-γ at the cost of th17-driven immunopathology. | the roles of th1 and th17 responses as mediators of host protection and pathology in the intestine are the subjects of intense research. in this study, we investigated a model of intestinal inflammation driven by the intracellular apicomplexan parasite eimeria falciformis. although ifn-γ was the predominant cytokine during e. falciformis infection in wild-type mice, it was found to be dispensable for host defense and the development of intestinal inflammation. e. falciformis-infected ifn-γr(-/-) ... | 2012 | 22266282 |
| dual rna-seq reveals no plastic transcriptional response of the coccidian parasite eimeria falciformis to host immune defenses. | parasites can either respond to differences in immune defenses that exist between individual hosts plastically or, alternatively, follow a genetically canalized ("hard wired") program of infection. assuming that large-scale functional plasticity would be discernible in the parasite transcriptome we have performed a dual rna-seq study of the lifecycle of eimeria falciformis using infected mice with different immune status as models for coccidian infections. | 2017 | 28870168 |