| weekly oral azithromycin as prophylaxis for agents causing acute respiratory disease. | since the 1950s the u.s. military has used intramuscular injections of benzathine penicillin g (bpg) to control outbreaks of respiratory disease. in an effort to find an alternative prophylaxis, a randomized field trial was conducted among 1,016 male u.s. marine trainee volunteers at high risk for respiratory disease. participants were evaluated for evidence of acute respiratory infection by serological tests on pretraining and posttraining sera (63 days apart). oral azithromycin prophylaxis (50 ... | 1998 | 9455517 |
| the association between serum sialic acid and asymptomatic carotid atherosclerosis is not related to antibodies to herpes type viruses or chlamydia pneumoniae. the atherosclerosis risk in communities (aric) study investigators. | total serum sialic acid is a recently investigated marker for cardiovascular mortality and carotid atherosclerosis. this study tested the hypothesis that past infection by herpes simplex type 1 or type 2 viruses or cytomegalovirus or chlamydia pneumoniae accounts for the association between serum total sialic acid and atherosclerosis. | 1997 | 9447421 |
| microbiologic efficacy of azithromycin and susceptibilities to azithromycin of isolates of chlamydia pneumoniae from adults and children with community-acquired pneumonia. | chlamydia pneumoniae was eradicated from the nasopharynges of 26 of 33 (78.8%) evaluable children and adults with community-acquired pneumonia who were treated with azithromycin. we tested 55 isolates of c. pneumoniae obtained from 46 of these patients against azithromycin. the mic at which 90% of the isolates were inhibited and the minimal chlamydiacidal concentration at which 90% of strains tested were killed of azithromycin for these isolates were both 0.5 microg/ml. seven patients remained c ... | 1998 | 9449287 |
| chlamydia pneumoniae antibody response in patients with acute myocardial infarction and their follow-up. | study populations: this study concerned the possible relations between seroreactivity to chlamydia pneumoniae and myocardial infarction. a group of 29 patients with acute myocardial infarction (ami), 74 members of a healthy control group, and a subgroup of 24 members of a healthy control group matched for age, sex, and coronary risk factors (hcm) were included in the study. in addition, we evaluated the ami group in a 1-year patients' follow-up study. we used two different tests to detect anti-c ... | 1998 | 9453516 |
| serological survey of chlamydial antibody in post-natal sera. | questionnaires (3426; 72.8%) and blood samples (3890; 82.6%) were analysed from 4704 women post-natally. the answers to the questionnaire confirmed that those patients living in areas with the highest percentage employed in agriculture were most likely to be in direct or indirect contact with sheep or sheep products. when the 788 (20.3%) of the sera with group specific antibody were examined for type-specific antibody, 291 (7.5%) reacted with chlamydia trachomatis, 153 (3.9%) with chlamydia pneu ... | 1997 | 9459402 |
| chlamydia pneumoniae antibodies in severe essential hypertension. | several studies have implied an association between chlamydia pneumoniae (c. pneumoniae) and cardiovascular disease. our study was designed to determine whether this organism is associated with severe essential hypertension in a multiracial british population. antibodies to c. pneumoniae were measured by microimmunofluorescence in 123 patients with chronic severe hypertension and 123 control subjects, matched for ethnic origin, age, sex, and smoking habit, admitted to the same hospital with vari ... | 1998 | 9461226 |
| [chlamydia pneumoniae as an etiologic factor in disease of the respiratory tract]. | the described recently species of chlamydia pneumoniae is the subject of a large number of scientific reports. the majority of infections caused by this microorganism are asymptomatic. however, a lot of cases of symptomatic infections have been described with both mild and severe clinical course. symptoms related to infection may affect both upper and lower parts of the respiratory tract and may be accompanied by disorders in other systems and organs. reports on the influence of chronic inflamma ... | 1997 | 9461735 |
| [severe pneumonia caused by chlamydia pneumoniae in a patient treated with steroids for bronchial asthma]. | a case of bilateral severe pneumonia caused by chlamydia pneumoniae has been described in a female patient with bronchial asthma. both the clinical course and massive radiological changes, as-well as the fact that pneumonia occurred during the patients hospitalization and the treatment with, among other drugs, prednisone lead to the presumptive diagnosis of hospital acquired pneumonia or tuberculosis. the instituted therapy turned out ineffective. only when chlamydia pneumoniae was found in the ... | 1997 | 9461730 |
| chlamydia pneumoniae antibody titers are significantly associated with acute stroke and transient cerebral ischemia: the west birmingham stroke project. | several studies have implied an association between chlamydia pneumoniae and atherosclerosis. our research was designed to investigate the association of this organism with strokes and transient cerebral ischemia. | 1998 | 9472881 |
| evidence for chlamydia pneumoniae infection in steroid-dependent asthma. | chlamydia pneumoniae is an obligate intracellular respiratory pathogen capable of persistent infection. seroepidemiologic studies and the results of open-label antimicrobial treatment of patients with non-steroid-dependent asthma have suggested a potential role for c. pneumoniae in asthma. | 1998 | 9475566 |
| [bronchitis and alveolitis in the course of chlamydia pneumoniae infection]. | a case of a 38-year old male with respiratory failure in the course of infection by chlamydia pneumoniae has been described. inflammation of bronchioles and alveoli was diagnosed on the basis of clinical examination and analysis of cellular components of bronchoalveolar lavage fluid (balf). the diagnosis was confirmed by bacteriological examination of the culture infected by the material collected from the patient. therapy with doxycycline was instituted which resulted in remission of symptoms. ... | 1997 | 9461732 |
| viruses and bacteria in the etiology of the common cold. | two hundred young adults with common colds were studied during a 10-month period. virus culture, antigen detection, pcr, and serology with paired samples were used to identify the infection. viral etiology was established for 138 of the 200 patients (69%). rhinoviruses were detected in 105 patients, coronavirus oc43 or 229e infection was detected in 17, influenza a or b virus was detected in 12, and single infections with parainfluenza virus, respiratory syncytial virus, adenovirus, and enterovi ... | 1998 | 9466772 |
| the in-vitro activity of grepafloxacin against chlamydia spp., mycoplasma spp., ureaplasma urealyticum and legionella spp. | the activity of grepafloxacin, a new orally active fluoroquinolone, was compared with the activities of ofloxacin, clarithromycin and doxycycline against chlamydia pneumoniae, chlamydia trachomatis, mycoplasma pneumoniae, mycoplasma hominis and ureaplasma urealyticum, and with the activities of ofloxacin, clarithromycin and rifampicin against legionella spp. grepafloxacin (mic range 0.06-0.12 mg/l) was some 8-16 times more active than ofloxacin against the chlamydiae, showing activity similar to ... | 1997 | 9484871 |
| grepafloxacin--a new fluoroquinolone. | | 1998 | 9465856 |
| multiple sclerosis associated with chlamydia pneumoniae infection of the cns. | | 1998 | 9484408 |
| infection with chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit model. | chlamydia pneumoniae infection has been associated with atherosclerosis by serological studies and detection of bacterial antigen within plaque. we sought to evaluate a possible causal role in an animal model. | 1998 | 9495296 |
| pneumococcal community-acquired pneumonia in 148 hospitalized adult patients. | in a previous prospective study, streptococcus pneumoniae was identified as the causative agent in 148 (42.8%) of 346 adult patients hospitalized over the course of one year with community-acquired pneumonia (cap) in the soroka medical center, beer-sheva, israel. the present study characterizes those cases in which streptococcus pneumoniae was the only pathogen and those in which additional etiological agents were identified. pneumococcal cap was diagnosed by standard blood cultures or positive ... | 1997 | 9495665 |
| chlamydia dna extraction for use in pcr: stability and sensitivity in detection. | we evaluated multiple procedures for extracting chlamydial dna from specimens for detection in pcr tests. commercial kits and an in-house method were tested for their sensitivity and utility. quantifiable chlamydial elementary bodies (eb) were used for spiking buffy coats from edta-collected blood. ebs of chlamydia pneumoniae at 2,500 and 25 eb/ml were used as specimens for dna extraction using seven different procedures. these included either columns (3 procedures), centrifugation (1), glass (1 ... | 1998 | 9484669 |
| [arteriosclerosis--a chlamydia pneumoniae infection?]. | | 1998 | 9487292 |
| adult respiratory distress syndrome due to chlamydia pneumoniae in a young adult. | a case of life-threatening chlamydia twar pneumonia complicated by encephalitis in a young, previously healthy adult is described. the patient presented with full blown adult respiratory distress syndrome and required prolonged ventilatory support and rigorous antibiotic and supportive care. he recovered fully without any neurologic sequelae. chlamydia pneumoniae pneumonia should be included in the differential diagnosis of the severe community acquired pneumonia, because if properly sought and ... | 1996 | 9499816 |
| [value and limitations of the microimmunofluorescence technique in the diagnosis of chlamydia infections in humans]. | | 1995 | 9506145 |
| [is arteriosclerosis an infectious disease?]. | there are three findings suggesting the inflammatory and immunogenic nature of the atherosclerosis: firstly the colocalisation of macrophages/monocytes and t-lymphocytes in all phases of the atherosclerosis, starting with intimal damages and developing into the end stage of atheromatous plaques, secondly the production of cytokines and thirdly the expression of mhc ii antigens. the persisting chlamydia pneumoniae bacteria infection, which has been repeatedly detected in the intima, sustains this ... | 1998 | 9492588 |
| antibody response to chlamydia pneumoniae infection in children with respiratory illness. | serologic diagnosis of chlamydia pneumoniae infection has been based on the microimmunofluorescence test (mif). however, recent prospective studies in children have found that >50% infected with c. pneumoniae failed to develop any antibodies detectable by mif. in this study, single sera from 46 culture-positive and 42 culture-negative children with respiratory infection and known mif status were examined by immunoblotting. forty-one (89.1%) of the single sera from culture-positive and 27 (64.3%) ... | 1998 | 9498453 |
| induction of macrophage foam cell formation by chlamydia pneumoniae. | foam cell formation is the hallmark of early atherosclerosis. it was found that the intracellular bacterium chlamydia pneumoniae induces foam cell formation by human monocyte-derived macrophages. exposure of macrophages to c. pneumoniae followed by low-density lipoprotein (ldl) caused a marked increase in the number of foam cells and accumulation of cholesteryl esters. foam cell formation was not inhibited by the antioxidant butylated hydroxytoluene nor fucoidan, suggesting that lipid accumulati ... | 1998 | 9498454 |
| chlamydia pneumoniae in children with acute respiratory tract infections. | children seeking medical attention for acute respiratory tract infections were investigated for evidence of chlamydia pneumoniae infection. blood samples were obtained from 367 children. nasopharyngeal or throat swabs for pcr analysis (polymerase chain reaction) were taken from 360 children. serology was found to be useful for diagnosis of infection only in children aged > 5 y. using pcr, a prevalence of 8 and 10% of c. pneumoniae was found in male and female children aged < 2 y; 17 and 19%, res ... | 1998 | 9510442 |
| role of infection as a risk factor for atherosclerosis, myocardial infarction, and stroke. | an increasing body of evidence has linked infections to atherosclerosis and thrombosis. herpesviruses cause atherosclerosis in experimental animals. herpesviruses can also be detected in atherosclerotic lesions in humans. cytomegalovirus may play a role in arteriosclerosis in transplanted hearts, and this virus, together with tumor suppressor protein p53, can be found in restenosis lesions following angioplasty. chlamydia pneumoniae and dental infections are associated with coronary heart diseas ... | 1998 | 9524851 |
| the effect of prolonged doxycycline therapy on chlamydia pneumoniae serological markers, coronary heart disease risk factors and forearm basal nitric oxide production. | chronic chlamydia pneumoniae infection, characterized by elevated levels of c. pneumoniae igg and iga antibodies and immunocomplexes, is associated with myocardial infarction and angiographically verified coronary heart disease. c. pneumoniae organisms have also been found in coronary atheromas, but not in healthy vessels. we investigated the effect of 4 months' doxycycline therapy on serological markers of c. pneumoniae infection and coronary risk factors. thirty-four non-smoking men, aged 57.9 ... | 1998 | 9511041 |
| [herd immunity and the role of chlamydia pneumoniae in the etiology of respiratory diseases in the czech republic]. | the objective of the investigation was to assess the seroprevalence of igg in the population of the czech republic and to assess the etiological role of chlamydia pneumoniae in respiratory diseases. the sera were examined by specific tests-genus by elisa and species by the microimmunofluorescent test. the examination of sera from 1974-1975 for the serological survey was selected to make the results comparable with the results of examinations planned for 1996. chlamydia igg were detected already ... | 1998 | 9511284 |
| characterization of a strain of chlamydia pneumoniae isolated from a coronary atheroma by analysis of the omp1 gene and biological activity in human endothelial cells. | chlamydia pneumoniae is a respiratory pathogen that has been associated with chronic inflammatory diseases such as asthma and atherosclerosis. recent isolation of c. pneumoniae from human carotid and coronary atheromas provides additional support for a role of this organism in atherogenesis. we characterized the coronary strain c. pneumoniae a-03 by sequence analysis of the major outer membrane protein gene (omp1). in addition, the in vitro activities of a-03 and three respiratory strains of c. ... | 1998 | 9529055 |
| human mannose-binding protein inhibits infection of hela cells by chlamydia trachomatis. | the role that collectin (mannose-binding protein) may play in the host's defense against chlamydial infection was investigated. recombinant human mannose-binding protein was used in the inhibition of cell culture infection by chlamydia trachomatis (c/tw-3/ot, e/uw-5/cx, and l2/434/bu), chlamydia pneumoniae (ar-39), and chlamydia psittaci (6bc). mannose-binding protein (mbp) inhibited infection of all chlamydial strains by at least 50% at 0.098 microg/ml for tw-3 and uw-5, and at 6.25 microg/ml f ... | 1998 | 9529088 |
| chlamydia pneumoniae: can it cause atherosclerosis? | | 1997 | 9529847 |
| endovascular presence of viable chlamydia pneumoniae is a common phenomenon in coronary artery disease. | we sought to examine coronary arteries for the presence of viable bacteria of the fastidious species chlamydia pneumoniae. | 1998 | 9525555 |
| chlamydia pneumoniae and cardiovascular disease. | | 1997 | 9534306 |
| lp(a) lipoprotein is a major risk factor for cardiovascular disease: pathogenic mechanisms and clinical significance. | the results of two previous and two recent studies of middle-aged males and females are presented to exemplify the clinical importance of lipoprotein(a) (lp(a)) as a risk factor for atherosclerosis and coronary heart disease. in these studies various conventional and recently suggested risk factors were included and different methods for lp(a) quantification were used. lp(a) was a significant risk factor in all four studies. in the recent prospective case-control study, lp(a) and cholesterol wer ... | 1997 | 9520117 |
| chlamydia pneumoniae is a risk factor for coronary heart disease in symptom-free elderly men, but helicobacter pylori and cytomegalovirus are not. | to test the hypothesis that chronic infection with chlamydia pneumoniae, helicobacter pylori or cytomegalovirus is associated with coronary heart disease risk in elderly men, a nested case-control study in a cohort investigated in 1985 and 1990 in the town of zutphen, the netherlands, was designed. fifty-four cases with a first diagnosed coronary event between 1985 and 1990, and 108 age-matched control subjects free of coronary heart disease during follow up were included in the study. the overa ... | 1998 | 9528823 |
| levofloxacin and sparfloxacin: new quinolone antibiotics. | to discuss the pharmacology, pharmacokinetics, spectrum of activity, clinical trials, and adverse effects of levofloxacin and sparfloxacin, two new fluoroquinolone antibiotics. | 1998 | 9533064 |
| [tricuspid endocarditis caused by chlamydia pneumoniae. apropos of a case]. | the authors report a case of tricuspid blood culture-negative endocarditis where serologic investigations showed high titers of antibodies against. chlamydia pneumoniae, thus suggesting its possible role as the causal agent. the treatment consisted of polymicrobial therapy using ciprofloxacine and doxycycline with favorable response thus avoiding surgical intervention. in all cases of culture-negative endocarditis not responding to classic empiric antibiotics, chlamydia infection should be suspe ... | 1997 | 9539844 |
| epidemiology of mild pneumonia. | clinicians define mild pneumonia as patients who are "not too sick," have normal respiratory and mental status, and are able to maintain oral intake. as yet there is no uniform definition of mild pneumonia. by inference, mild pneumonia occurs in younger patients with less comorbidity and has a better outcome than pneumonia that is moderate to severe. "atypical" pathogens such as mycoplasma pneumoniae, chlamydia pneumoniae and respiratory tract viruses are common causes of mild pneumonia. | 1998 | 9543470 |
| chlamydia pneumoniae in human abdominal aortic aneurysms. | to investigate the presence of chlamydia pneumoniae dna in the wall of infrarenal abdominal aortic aneurysms, and in the wall of non-aneurysmal infrarenal abdominal aortas. | 1998 | 9551052 |
| [changes of pathogenic microbes in respiratory infections in aged]. | | 1998 | 9549313 |
| distribution of chlamydia pneumoniae infection in the athersclerotic carotid artery. | chlamydia pneumoniae infection has recently become noteworthy in relation to atherosclerosis. we investigated by immunohistochemistry the distribution of c pneumoniae infection in the atherosclerotic carotid artery. | 1998 | 9550510 |
| failure to demonstrate chlamydia pneumoniae in symptomatic abdominal aortic aneurysms by a nested polymerase chain reaction (pcr). | to investigate whether chlamydia pneumoniae is present in symptomatic abdominal aortic aneurysms (aaa). | 1998 | 9551056 |
| in vitro activity of a new 8-methoxyquinolone, bay 12-8039, against chlamydia pneumoniae. | the in vitro susceptibilities of 10 strains of chlamydia pneumoniae to a new 8-methoxyquinolone, bay 12-8039, and to ofloxacin, doxycycline, and erythromycin were determined. the activity of bay 12-8039 was similar to that of ofloxacin, with a mic at which 90% of the isolates had no inclusions and a minimal chlamydicidal concentration at which 90% of the isolates had no inclusions after passage of 1.0 microg/ml, but this activity was less than those of doxycycline and erythromycin. | 1998 | 9559818 |
| chronic chlamydia pneumoniae infection and asthma exacerbations in children. | this study was undertaken to investigate the reported association between chlamydia pneumoniae and mycoplasma pneumoniae infection and the expression of asthma-related symptoms. one hundred and eight children with asthma symptoms, aged 9-11 yrs, completed a 13 month longitudinal study. the children maintained a daily diary of respiratory symptoms and peak flow rates. when respiratory symptoms were reported an investigator was called and a nasal aspirate obtained. in total 292 episodes were repor ... | 1998 | 9551736 |
| [bronchial asthma from chlamydia pneumoniae? epidemiology, risk factors and practical consequence for therapy]. | | 1998 | 9562721 |
| chlamydia pneumoniae and its role in chronic obstructive pulmonary disease. | the diverging of t-helper (th) cells into predominantly th1 and th2 subsets on the basis of their cytokine profiles has decisively improved our understanding of the pathogenesis of many chronic infectious diseases. recent data suggest that the presence of interferon-gamma and the subsequent suppression of interleukin-4 production leads to a th1-type response that is required for the resolution of infections caused by intracellular pathogens. the ability of the macrophages to respond aggressively ... | 1998 | 9556087 |
| can degenerative aortic valve stenosis be related to persistent chlamydia pneumoniae infection? | the cause of age-related degenerative (tricuspid) aortic valve calcification is largely unknown, but one typical characteristic is an active inflammatory process. the presence of chlamydia pneumoniae in aortic valve stenosis was recently shown. | 1998 | 9556468 |
| calculus and coronary artery disease. | | 1997 | 9560719 |
| [site of care provision, etiology and treatment of community-acquired pneumonia in palma de mallorca]. | it is not common that community-acquired pneumonias studies include patients non treated in hospital. the objectives were: to determine the cases managed in the ambulatory setting; to describe the clinical features; to identify the aetiological agents, and to describe the treatment, comparing inpatients with outpatients. | 1998 | 9567255 |
| chronic infection and atherogenesis. | | 1998 | 9568436 |
| absence of porphyromonas asaccharolytica, bacteroides fragilis and chlamydia pneumoniae in human subgingival plaque. | little is known about the presence of common medical pathogens in the human oral cavity. using a 16s rrna-based pcr identification method, this study determined the occurrence of porphyromonas asaccharolytica, bacteroides fragilis and chlamydia pneumoniae in subgingival plaque from 50 adults with advanced periodontitis. each patient contributed samples from 3 deep periodontal pockets collected by paper points. the pcr primers were for p. asaccharolytica 5'-ctc tag cta gag tgt act gg-3' and 5'-at ... | 1997 | 9573814 |
| fifty percent of patients with coronary artery disease do not have any of the conventional risk factors. | prinzmetal's variant angina, primarily a vasospastic disease, is a glaring example of the gaps in our knowledge regarding the etiology of coronary heart disease. half of all patients with coronary heart disease do not have any of the established coronary risk factors. prinzmetal's variant angina, syndrome x, coronary embolization, and congenital coronary anomalies, are a few examples of conditions that may not be associated with established risk factors. new risk factors that are emerging in an ... | 1998 | 9579251 |
| igg antibodies to chlamydial and mycoplasma infection plus c-reactive protein related to poor outcome in unstable angina. | evidence exists showing an association between chlamydial infection and infarction. our purpose was to identify an interactive relationship between chlamydia pneumoniae and unstable angina. | 1997 | 9585827 |
| chlamydia pneumoniae in the female genital tract. | | 1998 | 9570671 |
| demonstration of chlamydia pneumoniae in patients with chronic pharyngitis. | 12 patients with longstanding throat symptoms, who were also positive by pcr (polymerase chain reaction) for chlamydia pneumoniae were selected for a longitudinal study to determine whether c. pneumoniae is an aetiological agent for chronic pharyngitis. specimens for culture and pcr detection of c. pneumoniae were taken from the retropharyngeal wall and blood specimens were taken for serology. biopsies were taken from the mucosal membrane of the retropharyngeal wall for histological and immunohi ... | 1997 | 9571739 |
| interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease. | although first suggested at the turn of the 20th century, there is a renewed interest in the infectious theory of atherosclerosis. studies done in many laboratories around the world over the past several years have shown an association between markers of inflammation and coronary atherosclerosis with an exacerbation of the inflammatory process during acute myocardial ischemia, particularly in the early stages of reperfusion. it is also being recognized that the traditional risk factors, such as ... | 1998 | 9581711 |
| inhibition of chlamydia pneumoniae replication in hep-2 cells by interferon-gamma: role of tryptophan catabolism. | interferon-gamma (ifn-gamma) induces tryptophan catabolism in hep-2 cells, possibly via stimulation of host cell indoleamine-2,3-dioxygenase activity, in a dose-dependent (12.5-1600 u/ml) fashion after 24 h, resulting in a 99% conversion to its metabolites at 1600 u/ml. replication of chlamydia pneumoniae isolates a-03 and bal-16 was inhibited in hep-2 cells following treatment with 50 and 100 u/ml ifn-gamma, respectively; however, addition of excess l-tryptophan (200 microg/ml) to monolayers in ... | 1998 | 9593020 |
| lack of correlation between the detection of chlamydia trachomatis dna in synovial fluid from patients with a range of rheumatic diseases and the presence of an antichlamydial immune response. | to resolve how frequently chlamydia trachomatis and chlamydia pneumoniae dna are present in the joints of unselected patients with reactive arthritis (rea) and undifferentiated oligoarthritis, and to determine if there is an accompanying serologic or cellular antichlamydial immune response. | 1998 | 9588736 |
| antibiotic treatment of chlamydia pneumoniae for secondary prevention of cardiovascular events. | | 1998 | 9591758 |
| evidence of systemic dissemination of chlamydia pneumoniae via macrophages in the mouse. | chlamydia pneumoniae has been postulated to cause systemic disease by infection of monocytes/macrophages and spread via the blood or lymphatics. to investigate how c. pneumoniae disseminates, the ability of the organism to infect murine macrophages in vivo and whether infection can be transferred via macrophages were determined. c. pneumoniae was detected by direct plating, isolation, and polymerase chain reaction in alveolar macrophages from intranasally inoculated mice and peritoneal macrophag ... | 1998 | 9593019 |
| chlamydia pneumoniae and occlusive vascular disease: identification and characterization. | chlamydia pneumoniae, a respiratory pathogen, has been associated with occlusive vascular disease, including atherosclerosis and intimal hyperplasia, through seroepidemiologic studies. furthermore, using immunohistochemistry (ihc), polymerase chain reaction (pcr), transmission electron microscopy (tem), and in situ hybridization, this association has been reconfirmed by detecting this organism in atherosclerotic vascular tissue. this review summarizes and critically analyzes these findings and a ... | 1998 | 9596148 |
| comparative study of the clinical presentation of legionella pneumonia and other community-acquired pneumonias. | the aim of this study was to compare the clinical, biological, and radiologic features of presentation in the emergency ward of community-acquired pneumonia (cap) by legionella pneumophila (lp) and other community-acquired bacterial pneumonias to help in early diagnosis of cap by lp. three hundred ninety-two patients with cap were studied prospectively in the emergency department of a 600-bed university hospital. univariate and multivariate analyses were performed to compare epidemiologic and de ... | 1998 | 9596294 |
| bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (copd) requiring mechanical ventilation. | we carried out a comprehensive microbiological study of the upper and lower airways in patients with severe exacerbations of chronic obstructive pulmonary disease (copd) requiring mechanical ventilation in order to describe microbial patterns and analyze their clinical significance. quantitative cultures of tracheobronchial aspirates (tbas), bronchoscopically retrieved protected specimen brush (psb) and bronchoalveolar lavage fluid (balf) at admission to the icu and after 72 h, as well as serolo ... | 1998 | 9603129 |
| implications for macrolide treatment in community-acquired pneumonia. hopkins cap team. | to identify associated clinical parameters, concurrent respiratory tract infections, and the association between macrolide-based therapy and mortality in patients with community-acquired pneumonia ascribed to atypical. | 1998 | 9596295 |
| new and emerging infectious diseases. | | 1998 | 9601139 |
| increased fibrinogen levels are associated with persistent chlamydia pneumoniae infection in unstable coronary artery disease. | increased levels of acute phase proteins, e.g., fibrinogen, are related to a poor outcome in unstable coronary artery disease, but the cause of inflammation is unknown. we therefore investigated the prevalence of persistent chlamydia pneumoniae infection, and its relationship to inflammation in this condition. | 1998 | 9597405 |
| analysis of the humoral immune response to chlamydia outer membrane protein 2. | the humoral immune response to chlamydia outer membrane protein 2 (omp2) was studied. omp2 is a highly genus-conserved structural protein of all chlamydia species, containing a variable n-terminal fragment. to analyze where the immunogenic parts were localized, seven highly purified truncated fusion proteins constituting different regions of the protein were produced (chlamydia pneumoniae-omp2aa23-aa93, chlamydia psittaci-omp2aa23-aa94, and chlamydia trachomatis-omp2aa23-aa84, aa87-aa547, aa23-a ... | 1998 | 9605983 |
| chlamydia pneumoniae and exacerbations of asthma in adults. | chlamydia pneumoniae is a frequent causative agent of acute respiratory disease and has been recently reported as a possible cause of asthma. | 1998 | 9609611 |
| [means of diagnosis of chlamydia pneumoniae infection]. | | 1997 | 9616810 |
| [does infectious asthma exist?]. | | 1997 | 9616814 |
| [chlamydia pneumoniae and asthmatic disease in adults: relations to be clarified]. | | 1997 | 9616812 |
| in vitro activity of a new ketolide antibiotic, hmr 3647, against chlamydia pneumoniae. | the in vitro activities of hmr 3647, roxithromycin, erythromycin, and azithromycin against 19 strains of chlamydia pneumoniae were tested. the mic at which 90% of the isolates are inhibited and the minimum bactericidal concentration at which 90% of the isolates are killed of hmr 3647 were 0.25 microgram/ml (range, 0.015 to 2 micrograms/ml). nine recently obtained clinical isolates from children with pneumonia were more susceptible (mics, 0.015 to 0.0625 microgram/ml) than older strains that had ... | 1998 | 9624507 |
| [role of chlamydia pneumoniae in asthmatic disease in children]. | | 1997 | 9616813 |
| [chlamydia pneumoniae and respiratory pathology. epidemiological data]. | | 1997 | 9616811 |
| can antibiotics prevent heart disease? | | 1998 | 9619136 |
| [antibiotics against myocardial infarction? the risk of resistance development must be considered]. | | 1998 | 9630791 |
| [arteriosclerosis caused by infection? a possible link between chlamydia pneumoniae and atherosclerosis]. | infection as a possible underlying cause of atherosclerosis has aroused increasing interest in recent years, chlamydia pneumoniae being one of the organisms upon which attention has been focused. newly published results of antibiotic treatment of vascular disease not only appear to provide further support for the infection hypothesis, but also suggest a quite different approach to the treatment of atheromatous cardiovascular disease. however, confirmatory clinical trials will be needed before an ... | 1998 | 9630800 |
| expansion of a novel pulmonary cd3(-) cd4(+) cd8(+) cell population in mice during chlamydia pneumoniae infection. | a new pulmonary t-cell-like lymphocyte population with the phenotype cd3(-) cd4(+) cd8(+) was discovered in mice. cd4(+) cd8(+) but cd3(+) cells among murine intestinal intraepithelial lymphocytes have previously been described. we describe herein a dramatic expansion of the cd3(-) cd4(+) cd8(+) cell population in response to experimental respiratory infection. after intranasal chlamydia pneumoniae infection, cd4(+) cd8(+) cells became transiently the dominant lymphocyte type (maximum of 87% of ... | 1998 | 9632597 |
| chronic follicular conjunctivitis associated with chlamydia psittaci or chlamydia pneumoniae. | we determined whether patients with chronic conjunctivitis in whom direct fluorescent antibody (dfa) tests revealed genus-specific chlamydial antigens (but not species-specific chlamydia trachomatis antigens) were infected with chlamydia psittaci or chlamydia pneumoniae. patients were divided into a case group of possible non-trachomatis chlamydial conjunctivitis and a control group of nonchlamydial conjunctivitis on the basis of examination and dfa testing. species-specific primers were used to ... | 1998 | 9636859 |
| evaluation of infectious etiology in subacute thyroiditis--lack of association with coxsackievirus infection. | the etiology of subacute granulomatous thyroiditis (sat) is obscure, although it is postulated to be associated with viral infections and genetic factors. in the present study, the possibility of an infectious etiology was prospectively studied in 27 consecutive patients with sat. special emphasis was put on the role of enteroviruses. coupled sera (interval one month) were taken from all patients and single sera from 29 control subjects for virus antibody determinations. stool samples were colle ... | 1998 | 9637274 |
| failure to detect chlamydia pneumoniae in atherosclerotic plaques of australian patients. | chlamydia pneumoniae is a recently reported, but common, respiratory tract pathogen. the organism has been detected by electron microscopy, immunocytochemistry, polymerase chain reaction (pcr) and recently culture within atherosclerotic plaques, suggesting a possible association between c. pneumoniae infection and atherosclerosis. interestingly this association has not been found by all researchers. we examined 17 carotid endarterectomy specimens, 16 carotid arteries and 16 coronary arteries fro ... | 1998 | 9643499 |
| chlamydia pneumoniae in vascular tissues from heart-transplant donors. | | 1998 | 9643755 |
| fundamentals of clinical methodology: 2. etiology. | the concept of etiology is analyzed and the possibilities and limitations of deterministic, probabilistic, and fuzzy etiology are explored. different kinds of formal structures for the relation of causation are introduced which enable us to explicate the notion of cause on qualitative, comparative, and quantitative levels. the conceptual framework developed is an approach to a theory of causality that may be useful in etiologic research, in building nosological systems, and in differential diagn ... | 1998 | 9626958 |
| chlamydia pneumoniae-specific cell-mediated and humoral immunity in healthy people. | in this work, cell-mediated immunity to chlamydia pneumoniae was studied in 157 healthy individuals using lymphoproliferative assay and serum antibodies were analysed by microimmunofluorescence techniques. the c. pneumoniae-specific igg antibodies were elevated more frequently and the geometric mean titres for igg (67.5 versus 44.1; p = 0.05) and iga (14.9 versus 11.3; p = 0.025) antibodies were significantly higher in males than in females. however, no gender-dependent differences were observed ... | 1998 | 9627138 |
| chlamydia pneumoniae. | | 1998 | 9627150 |
| [coronary heart disease as inflammatory disease of the vascular bed? etiology, sequela or misconception?]. | in this editorial the traditional risk factors are contrasted with more recent modifications of the response to injury theory including the modified ldl-response to injury and the immunological response to injury theories. this issue of "herz" is devoted to the missing points in the classic risk factor concepts and revisits them as well as the infectious theory with chlamydia pneumoniae, cytomegalovirus and helicobacter pylori as well as the autoreactivity hypothesis. | 1998 | 9646095 |
| [persistence of chlamydia pneumoniae in human arteriosclerotic plaque substance. evidence and consequences]. | the obligate intracellular bacterium chlamydia pneumoniae has recently been implicated in the pathogenesis of atherosclerosis. serological response to chlamydia pneumoniae statistically indicates an increased risk of coronary artery disease and myocardial infarction. this surprising relation is corroborated by the presence of chlamydial structures and even viable chlamydia pneumoniae in atherosclerotic plaques. these findings have already resulted in initial studies on the potential benefit of a ... | 1998 | 9646099 |
| [arteriosclerosis as a sequela of chronic chlamydia pneumoniae infection]. | in the last years several new data allow a controversial but convincing interpretation of the pathogenesis of atherosclerosis (arteriosclerosis). atherosclerosis can be apparently the result of ultrachronic persistent infection by chlamydia pneumoniae and not the result of different risk factors. the main arguments for the chlamydial genesis are: 1. correlation of coronary heart disease and other atherosclerotic disease with antibodies against c. pneumoniae. 2. c. pneumoniae could be detected wi ... | 1998 | 9646100 |
| [cytomegalovirus and herpes simplex virus in pathogenesis and progression of native arteriosclerosis and recurrent stenosis after intervention]. | an increasing number of clinical and experimental studies point to a contribution of various infectious organisms like chlamydia pneumoniae or herpesviruses to atherosclerosis in man. cytomegalovirus induces atherosclerotic lesions in animals. in vitro studies reveal functional changes of endothelial cells after infection with cytomegalovirus. infection with this virus renders endothelial cells immunogenic for cellular and humoral immune reactions. in man a significant association of infections ... | 1998 | 9646101 |
| high prevalence of chlamydia pneumoniae dna in peripheral blood mononuclear cells in patients with cardiovascular disease and in middle-aged blood donors. | nested polymerase chain reaction (npcr) demonstrated the presence of chlamydia pneumoniae-specific dna in peripheral blood mononuclear cells (pbmc). pbmc samples were obtained from 103 consecutive patients (62 male, 41 female) aged 22-85 years (mean, 64) admitted for coronary angiography because of suspected coronary heart disease and from 52 blood donors (43 male, 9 female) aged 40-64 years (mean, 49). of the 101 evaluable patients, 60 (59%) were identified by npcr assay as c. pneumoniae dna ca ... | 1998 | 9652454 |
| previous cytomegalovirus or chlamydia pneumoniae infection and risk of restenosis after percutaneous transluminal coronary angioplasty. | | 1997 | 9652570 |
| rapid detection of chlamydia pneumoniae by pcr-enzyme immunoassay. | chlamydia pneumoniae is an important human respiratory pathogen. laboratory diagnosis of infection with this organism is difficult. to facilitate the detection of c. pneumoniae by pcr, an enzyme immunoassay (eia) for analysis of pcr products was developed. biotin-labeled pcr products generated from the 16s rrna gene of c. pneumoniae were hybridized to a digoxigenin-labeled probe and then immobilized to streptavidin-coated microtiter plates. bound pcr product-probe hybrids were detected with anti ... | 1998 | 9650931 |
| chlamydia pneumoniae in children attending day-care centers in gävle, sweden. | the epidemiology of chlamydia pneumoniae in healthy children has not been established. | 1998 | 9655537 |
| use of lambda phage dna as a hybrid internal control in a pcr-enzyme immunoassay to detect chlamydia pneumoniae. | an inherent problem in the diagnostic pcr assay is the presence of ill-defined inhibitors of amplification which may cause false-negative results. addition of an amplifiable fragment of foreign dna in the pcr to serve as a hybrid internal control (hic) would allow for a simple way to identify specimens containing inhibitors. two oligonucleotide hybrid primers were synthesized to contain nucleic acid sequences of the chlamydia pneumoniae 16s rrna primers in a position flanking two primers that ta ... | 1998 | 9650936 |
| an association of an antibody against chlamydia pneumoniae and coronary heart disease observed in japan. | | 1998 | 9651727 |
| association of chlamydia pneumoniae with chronic juvenile arthritis. | | 1998 | 9665306 |
| alternative hypothesis for efficacy of macrolides in acute coronary syndromes. | | 1998 | 9652673 |
| [clinical aspects of chlamydia respiratory tract infections and their role in the pathogenesis of asthma]. | recent world-wide publications were reviewed in order to determine the clinical characteristics and therapeutic relevance of the chlamydial respiratory tract infections in humans. it was emphasized that chlamydia pneumoniae could initiate asthma and may be associated with acute asthma exacerbation. laboratory procedures for identifying chlamydia and difficulties concerned with the diagnostics of this intracellular pathogen were also presented. in patients with evidence of chlamydial infection th ... | 1998 | 9658998 |
| comparison of throat swabs with sputum specimens for the detection of chlamydia pneumoniae antigen by direct immunofluorescence. | to compare throat swabs with sputum specimens for chlamydia pneumoniae antigen detection. | 1998 | 9659245 |
| characterization of a neutralizing monoclonal antibody directed at the lipopolysaccharide of chlamydia pneumoniae. | identification of protective epitopes is one of the first steps in the development of a subunit vaccine. one approach to accomplishing this is to identify structures or epitopes by using monoclonal antibodies (mab) that can attenuate infectivity in vitro and in vivo. to date attempts to use this approach with chlamydia pneumoniae have failed. this report is the first description of a mab directed to the lipopolysaccharide (lps) of chlamydia that neutralizes both in vitro and in vivo the infectiv ... | 1998 | 9673271 |