[clinical study of rapid bladder filling agent].the rapid bladder filling agent (rbfa) was prepared with polyporus umbellatus, poria cocos and furosemidum. the urinary volume and the best filling time of urinary bladder were observed with ultrasonography in 211 cases. the result showed that in experimental group the largest urinary volume in unit time was more than that in control group and shortest filling time was shorter (30.35 +/- 7.9 min) in comparing with control group (145.6 +/- 50.1 min). clinical observation for 1180 cases proved tha ...19921298469
[clinical and experimental study on the treatment of children diarrhea by granule of children-diarrhea fast-stopping].granule of children-diarrhea fast-stopping is a proved recipe composed of seven medical herbs such as poria cocos, haw charcoal, euphorbia humifusa, etc. after more 20 years' clinical application of 419 cases, the total effective rate proved to be 96.4% and the cure rate 90%, much better than the control groups [tcm: gelian san and shenglingbaizhu san; wm: gentamycin and ppa]. it had the effect of fast-stopping diarrhea and shortening the recovery period. it also had excellent curative effect fo ...19912060055
[preparation of poria cocos biscuits]. 19852937569
[triterpenoids of hoelen (fuling), sclerotia of poria cocos (schw.) wolf. i]. 19705463480
[effects of poria cocos on ototoxicity induced by kanamycin in guinea-pigs].in order to prevent the ototoxicity of kanamycin (km), the effects of poria cocos (pc) on the ototoxicity induced by km in guinea-pigs was observed by infusing the pc decoction into the guinea-pigs with comparing the difference in the general intoxicating symptom, prayer's reflex (pr) threshold, brainstem auditory evoked potentials (baeps) and the absence rate of outer hair cells in the first turn of cochlea. the results suggested that the ototoxicity of km was retarded by giving the pc decoctio ...19957580066
[studies on chemical constituents from solvent extracts of poria cocos (schw.) wolf].crystals i-n were isolated from the ethereal extracts of poria cocos and identified respectively as o-acetyl-pachymic acid (i), 3 beta-hydroxy-lanosta-7,9(11),24-trien-21-oic acid (ii), beta-amyrin acetate (iii) and 3 beta-hydroxy-16 alpha-acetoxy-lanosta-7,9(11),24-trien-21-oic acid (n). crystal iii was obtained from p. cocos for the first time, and crystal n was newly discovered.19938003216
isolation of inhibitors of tpa-induced mouse ear edema from hoelen, poria cocos.triterpene carboxylic acids were isolated from the methanol extract of hoelen, poria cocos, and found to inhibit 12-o-tetradecanoylphorbol 13-acetate (tap)-induced mouse ear edema. their chemical structures were identified as 3 beta,-16 alpha-dihydroxylanosta-7,9(11),24-trien-21-oic acid, 16 alpha-hydroxydehydropachymic acid, 16 alpha-hydroxytrametenolic acid and dehydrotumulosic acid.19968681415
fu-ling, a chinese herbal drug, modulates cytokine secretion by human peripheral blood monocytes.fu-ling, the sclederma of poria cocos (schw.) wolf, has long been used as a sedative and diuretic in traditional chinese herbal medicine. our study demonstrated that the substances extracted from fu-ling by 50% hot ethanol significantly augmented the secretion of interleukins il-1 beta and il-6 6 h after in vitro cultivation of human peripheral blood monocytes. the augmented effect was dose dependent. tumour necrosis factor-alpha (tnf-alpha) secretion was also increased as the cells were treated ...19968732431
inhibitory effects of lanostane-type triterpene acids, the components of poria cocos, on tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.pachymic acid, 3-o-acetyl-16 alpha-hydroxytrametenolic acid, and poricoic acid b had been isolated from the sclerotium of poria cocos wolf. these compounds showed a strong inhibitory activity against 12-o-tetradecanoylphorbol-13-acetate-induced inflammation in mice. at 0.2 mumol/mouse, these compounds markedly inhibited the promoting effect of 12-o-tetradecanoylphorbol-13-acetate (1 microgram/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/m ...19968784472
sulphorhodamine b assay for measuring proliferation of a pigmented melanocyte cell line and its application to the evaluation of crude drugs used in the treatment of vitiligo.a rapid 96-well plate assay using sulphorhodamine b (srb) protein stain for cell number has been adopted to screen herbs used in traditional treatments of vitiligo for substances capable of stimulating melanocyte proliferation. its applicability to melan-a cells, a mouse pigmented cell line, has been validated. srb assay produced good linearity up to 11 x 10(4) cells/well and interference by melanin present in the cells accounted for less than 10% of the total optical density readings. the intra ...199910433470
antidepressant effects of banxia houpu decoction, a traditional chinese medicinal empirical formula.banxia houpu decoction, having been used for the treatment of depression-related diseases since ancient times, is a traditional chinese medicinal empirical formula consisting of pinellia ternata, poria cocos, magnolia officinalis, perilla frutescens and zingiber officinale. the effects of the total decoction extract and five fractions therefrom, were evaluated in mice by tail suspension and forced swimming tests. the total 90% ethanol extract of the decoction was shown to possess an antidepressa ...200011025166
on the anti-inflammatory and anti-phospholipase a(2) activity of extracts from lanostane-rich species.we have studied extracts from three species rich in lanostane triterpenes for their activity against different in vivo models of inflammation induced by tpa, epp and pla(2). the inhibitory effect against pla(2) in vitro was also studied. when the poria cocos extract was tested against pla(2)-induced mouse paw edema, it was active by the oral and parenteral routes. its effect was greater in both magnitude and duration than that of pistacia terebinthus and ganoderma lucidum extracts. p. terebinthu ...200011025140
3 beta-p-hydroxybenzoyldehydrotumulosic acid from poria cocos, and its anti-inflammatory effect.the structure of a new triterpene derivative isolated from poria cocos was determined to be 3 beta-p-hydroxybenzoyldehydrotumulosic acid by spectral and chemical methods. 3 beta-p-hydroxybenzoyldehydrotumulosic acid showed marked inhibitory activity against 12-o-tetradecanoylphorbol-13-acetate (tpa)- and arachidonic acid (aa)-induced ear inflammation in mice. the 50% inhibitory doses of 3 beta-p-hydroxybenzoyldehydrotumulosic acid were 0.27 and 1.25 mg per ear on tpa- and aa-induced inflammation ...19989720314
liu-wei-dihuang: a study by pulse analysis.pulse analysis method was used in studying the traditional chinese formula liu-wei-dihuang as well as five of its main components (rehmannia glutinosa, cornus officinalis, paeonia suffruticosa, poria cocos and alisma plantogo-aquatica var oriental). based on our recently developed resonance theory, we tried to elucidate the mechanism and mutual reactions of these meridian related herbs. hot water herbal extracts were injected intraperitoneally into rats and the pressure pulse spectrum at the cau ...19989592596
effect of the basidiomycete poria cocos on experimental dermatitis and other inflammatory conditions.the hydroalcoholic extract from p. cocos was examined for oral and topical anti-inflammatory activities. it proved to be active against carrageenan, arachidonic acid, tetradecanoyl phorbol acetate (tpa) acute edemas, tpa chronic inflammation and oxazolone delayed hypersensitivity in mice. two lanostane-type triterpenes were isolated and identified by spectroscopic methods as dehydrotumulosic and pachymic acids. their id50 on acute tpa edema was 4.7 x 10(-3) and 6.8 x 10(-4) mumol/ear, respective ...19979085556
anti-emetic principles of poria cocos.the triterpenes isolated from p. cocos and their derivatives were examined for anti-emetic activity. some of these triterpenes inhibited emetic action induced by oral administration of copper sulfate pentahydrate to leopard frog. the triterpenes having an exomethylene group at c-24 showed anti-emetic activity to frogs.19958824947
inhibition of tumor-promoting effects by poricoic acids g and h and other lanostane-type triterpenes and cytotoxic activity of poricoic acids a and g from poria cocos.the structures of two novel 3,4-seco-lanostane-type triterpenes isolated from the sclerotium of poria cocos were established to be 16alpha-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid (1; poricoic acid g) and 16alpha-hydroxy-3,4-seco-24-methyllanosta-4(28),8,24(24(1))-triene-3,21-dioic acid (2; poricoic acid h) on the basis of spectroscopic methods. these two, and eight other known compounds isolated from the sclerotium, poricoic acid b (3), poricoic acid a (4), tumulosic acid (5), ...200211975480
a polysaccharide produced by laboratory cultivation of poria cocos wolf. 19807438140
inhibition of trypanosoma cruzi growth by medical plant extracts.this study describes the screening of extracts obtained from 18 plants and two fungi used in the chinese and mediterranean traditional medicines on epimastigote forms of trypanosoma cruzi. the extracts were tested against epimastigote of t. cruzi bra c15c2 clone in vitro at 27 degrees c and at a concentration of 250 microg/ml in axenic culture. angelica dahurica, a. pubescens, a. sinensis, astragalus membranaceus, coptis chinensis, haplophyllum hispanicum, phellodendron amurense, poria cocos, ra ...200212490214
[studies on the antitumor active polysaccharides from the mycelia of poria cocos wolf. iii. antitumor activity against mouse tumors]. 19863735073
[studies on the antitumor-active polysaccharides from the mycelia of poria cocos wolf. ii. structural analysis of antitumor polysaccharide h11]. 19863723343
[comparative test on spawn culture materials of poria cocos].it saves much time, work and timber when poria cocos spawn is made from cottonseed hulls and pine sawdust. compared with the yields from pine wood chip, the difference is not significant.199712572489
[studies on the antitumor-active polysaccharides from the mycelia of poria cocos wolf. i. fractionation and purification of antitumor polysaccharide h11]. 19863723342
inhibitory effects of triterpenes isolated from hoelen on free radical-induced lysis of red blood cells.hoelen, sclederma of poria cocos wolf, has long been used as a sedative and diuretic in traditional medicine. formerly, we demonstrated that hoelen in vitro protects red blood cells from aaph-induced hemolysis. in this study, tests were carried out to identify the main ingredient of hoelen that has the scavenging effect on free-radicals. triterpene carboxylic acids isolated from the methanol extract of hoelen, i.e. pachymic acid, polyporenic acid, 3-epidehydrotumulosic acid, 3beta-hydroxylanosta ...200312601680
effects of a chinese herbal medicine, keishi-bukuryo-gan, on the gonadal system of rats.keishi-bukuryo-gan (tj-25) is a traditional chinese herbal remedy containing five components: bark of cinnamomum cassia, root of paeonia lactiflora, seed of prunus persica or p. persiba var. davidiana, carpophores of poria cocos and root bark of paeonia suffruticosa. this preparation has been used in the treatment of gynecological disorders such as hypermenorrhea, dysmenorrhea and infertility. in the present study, the effects of tj-25 on plasma levels of luteinizing hormone (lh), follicle-stimu ...19883143030
[an experimental study on the anti-senility effects of shou xing bu zhi].this paper presents the anti-senility effects of shou xing bu zhi (sxbz. made of thirteen herbs: polygonum multiflorum, codonopsis silvestris, astragalus membranaceus, poria cocos, etc.) in mice. the mice were administered with the sxbz orally at dosage of 10 g/kg daily for three months. the results showed that the lipofuscin of liver and brain tissues was significantly reduced in both young (1 month old) and adult (11 months) mice. examination of lipid peroxidation of liver tissue revealed a ma ...19892758519
studies on antinephritic effects of plant components (3): effect of pachyman, a main component of poria cocos wolf on original-type anti-gbm nephritis in rats and its mechanisms.the antinephritic effect of pachyman on original-type anti-gbm nephritis in rats was investigated. pachyman was given to original-type anti-gbm nephritic rats for 10 days from the day of anti-gbm serum injection. pachyman prevented urinary protein excretion and the elevation of serum cholesterol content. histopathological observations of the glomeruli indicated that although the number of nuclei and adhesion to capillary walls of bowman's capsule in nephritic control rats were significantly incr ...19921507662
pharmacotherapeutic effects of kuei-chih-fu-ling-wan (keishi-bukuryo-gan) on human uterine myomas.kuei-chih-fu-ling-wan (keishi-bukuryo-gan; kbg), a traditional chinese herbal remedy contains five components: bark of cinnamomum cassia bl. (lauraceae), root of paeonia lactiflora pall. (paeoniaceae), seed of prunus persica batsch. or p. persiba batsch.var.davidiana maxim. (rosaceae), carpophores of poria cocos wolf. (polyporaceae), and root bark of paeonia suffruticosa andr. (paeoniaceae). this prescription has been frequently used in the treatment of gynecological disorders such as hypermenor ...19921471615
suppression of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and granulocyte-monocyte colony stimulating factor secretion from human monocytes by an extract of poria cocos.fu-ling, the sclederma of poria cocos (schw.) wolf, has long been used as a sedative and diuretic. however, data in this report suggest that fu-ling is a potential suppressor of cytokine secretion from human peripheral blood monocytes under in vitro condition. monocyte culture medium containing 10% of fu-ling extract significantly inhibited secretion of tnf-alpha, il-beta, il-6 and gm-csf from the monocyte monolayer. however, as fu-ling extract content was gradually reduced, cytokine secretion w ...19921306145
shi-quan-da-bu-tang (ten significant tonic decoction), sqt. a potent chinese biological response modifier in cancer immunotherapy, potentiation and detoxification of anticancer drugs.shi-quan-da-bu-tang (ten significant tonic decoction), or sqt (juzentaihoto, tj-48) was formulated by taiping hui-min ju (public welfare pharmacy bureau) in chinese song dynasty in ad 1200. it is prepared by extracting a mixture of ten medical herbs (rehmannia glutinosa, paeonia lactiflora, liqusticum wallichii, angelica sinesis, glycyrrhiza uralensis, poria cocos, atractylodes macrocephala, panax ginseng. astragalus membranaceus and cinnamomum cassia) that tone the blood and vital energy, and s ...19921294861
observation on the effects of chinese medicine zhenxuanyin for improving cerebral blood flow in rats with cerebral ischemia.zhenxuanyin [symbol: see text] is composed of pure chinese medicinal herbs, such as gastrodia tuber, poria cocos, ligusticum wallichii etc. 4-verssel occlusion (4vo) model rats were reperfused after 30 minutes' complete occlusion, and zhenxuanyin was administered 3 times a day. 24 hours later, 123i-imp uptake in the brain was evaluated as an index of cerebral blood flow (cbf). the results show that zhenxuanyin (0.03 g/kg, 0.3 g/kg, 1 g/kg, or 3 g/kg a day) can greatly improve the blood flow in t ...199710437217
two fungal lanostane derivatives as phospholipase a2 inhibitors.the hydroalcoholic extract of poria cocos and two lanostane derivatives isolated from it, pachymic acid (1) and dehydrotumulosic acid (2), were active as inhibitors of phospholipase a2 from snake venom when a polarographic method was used. dehydrotumulosic acid exhibited an ic50 of 0.845 mm. these two compounds are structurally related to certain triterpenoids from ganoderma and schinus that have previously been described as competitive inhibitors of phospholipase a2. these comprise a new group ...19968984162
hoelen (poria cocos wolf) and ginseng (panax ginseng c. a. meyer), the ingredients of a chinese prescription dx-9386, individually promote hippocampal long-term potentiation in vivo.dx-9386 is a traditional chinese medicinal prescription consisting of ginseng (panax ginseng c. a. meyer), polygala (polygala tenuifolia willdenew), acorus (acorus gramineus soland) and hoelen (poria cocos wolf). we recently found that oral administration of the prescription at a dose of 500 mg/kg intensified the formation of long-term potentiation (ltp) in the dentoff gyrus of anesthetized rats. to evaluate the individual contribution of separate ingredients in dx-9386 towards the observed biol ...19957655419
[a clinical study on the treatment of acute upper digestive tract hemorrhage with wen-she decoction].this paper deals with the prospective clinical study on treatment of acute upper digestive tract hemorrhage with wen-she decoction (wsd). an opened sequential controlled trial method of simple orientation quality reaction was adopted in this study. 7 cases were treated and all of them were cured. it was concluded that wsd was an excellent therapy to treat the middle or small amount hemorrhage of acute upper digestive tract. the effective rate of wsd of the stool ob (+) becoming (-) within 5 days ...19892766422
[tinnitus treated with combined traditional chinese medicine and western medicine].cases of annoying tinnitus were selected for this observation. they were examined by general physical examination, otoscopy and some of them by audiometry and tinnitus masking patterns test, and/or ecoch g and bser. two groups, tcm-wm and controls, were designed with patient's sexes, ages, severity of tinnitus almost evenly distributed. different kinds of medicines were given to the patients of 2 groups with single blind trial. for the controls, only western medicines such as valium, nicotinic a ...19892766421
[preparative approach to mannobiose and laminaribiose (author's transl)].for synthetic purposes mannobiose is isolated from the polysaccharide mannan of ivory nut flower. the chain length of mannan a is determined to approximately 15 mannose units on average with a definite distribution from 5 to 25 mannose units. acetolysis is optimized and yields 41% mannobiose. the separation on sephadex g-15 yields pure mannobiose, and in addition its higher homologues in gram amounts. detection of the eluates is performed using a differential refractometer. correspondingly lamin ...1977856848
preliminary observation on carboxyl-methyl poria cocos polysaccharide (cmpcp) in treating chronic viral hepatitis. 19846570501
[inhibitory activity of dianthus superbus l. and 11 kinds of diuretic traditional chinese medicines for urogenital chlamydia trachomatis in vitro].to detect the susceptibility of urogenital chlamydia trachomatis(ct) to 12 kinds of diuretic traditional chinese medicines.200012516457
evaluating the basidiomycetes poria medula-panis and wolfiporia cocos for xylanase production.xylanase, oxidative enzymes and iron-binding compounds were detected in the filtrates of wolfiporia cocos and poria medula-panis grown in wheat bran liquid medium. xylanase and iron-binding compounds were produced at high levels by the brown-rot fungus (br) w. cocos and at low levels by the white-rot fungus (wr) p. medula-panis. phenoloxidase was produced only by p. medula-panis. polyacrylamide gel electrophoresis (page) (sds-page) showed a wide variety of bands for extracellular proteins produc ...200111267647
[effect of water extract of poria on cytosolic free calcium concentration in brain nerve cells of neonatal rats].to investigate the effect of poria cocos, a chinese medicinal herb, on cytosolic free calcium concentration ([ca2+]i) in brain nerve cells of neonatal rats.199811477929
influence of traditional chinese anti-inflammatory medicinal plants on leukocyte and platelet functions.the enzymes 5-lipoxygenase and elastase are therapeutic targets in dermatological disorders such as psoriasis. fifteen extracts from traditional chinese medicinal plants used to treat topical inflammations were screened for their inhibitory effect on lipoxygenase, cyclooxygenase and elastase activity in intact leukocytes and platelets. astragalus membranaceus, forsythia suspensa and poria cocos inhibited 5-lipoxygenase, with ic50 values of 141, 80 and 141 microg ml(-1), respectively. the latter ...200314604471
dehydrotrametenolic acid induces preadipocyte differentiation and sensitizes animal models of noninsulin-dependent diabetes mellitus to insulin.we recently discovered that the triterpene acid compound dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. this natural product has been isolated from dried sclerotia of poria cocos wolf (polyporaceae), a well-known traditional chinese medicinal plant. we examined the effects of dehydrotrametenolic acid on plasma glucose concentration in obese hyperglycemic db/db mice. dehydrotrametenolic acid can reduce hyperglycemia in mouse models ...200211824563
antioxidant activity of anti-inflammatory plant extracts.the antioxidant properties of twenty medical herbs used in the traditional mediterranean and chinese medicine were studied. extracts from forsythia suspensa, helichrysum italicum, scrophularia auriculata, inula viscosa, coptis chinensis, poria cocos and scutellaria baicalensis had previously shown anti-inflammatory activity in different experimental models. using free radical-generating systems h. italicum. i. viscosa and f. suspensa protected against enzymatic and non-enzymatic lipid peroxidati ...200211860151
biochemical and microstructural ccharacteristics of insoluble and soluble dietary fiber prepared from mushroom sclerotia of pleurotus tuber-regium, polyporus rhinocerus, and wolfiporia cocos.the proximate composition of sclerotia of pleurotus tuber-regium, polyporus rhinoceros, and wolfiporia cocos, together with the yield, purity, monosaccharide profile, and microstructure of their insoluble dietary fiber (idf) and soluble dietary fiber (sdf) fractions prepared from aoac enzymatic-gravimetric methods were investigated and compared. all three sclerotia were typical carbohydrate rich sclerotia [ranging from 90.5 to 98.1% dry matter (dm)] with an exceptionally low amount of crude lipi ...200314611193
the isolation, identification and determination of dehydrotumulosic acid in poria cocos.poria cocos (fuling), a popular chinese medicinal (cm) herb of fungal origin, has been included in many combinations with other cm herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body. dehydrotumulosic acid, one of the effective constituents of fuling, was isolated from the chloroform-soluble material of ethanol extract of the fungu ...200212036119
[effect of improving memory and inhibiting acetylcholinesterase activity by invigorating-qi and warming-yang recipe].invigorating-qi and warming-yang (iqwy) had a good curative effect to some senile diseases such as senile dementia, senile hypomnesia etc. this experiment was designed for probing into the therapeutical mechanism of iqwy recipe. balb/c pure bred mice were divided into five groups. group i was taken per os of invigorating qi (iq), group ii warming yang (wy), group iii iqwy drugs, group iv was dysmnesia model, and group v blank control group injected with normal saline only. all groups except grou ...19938155947
the antiplatelet activity of danggijakyaksan by inhibition of phospholipase c.we investigated the effects of the traditional korean prescription, danggijakyaksan (djs) on antiplatelet activity in human platelet suspensions. the effect of oriental medicinal prescriptions, danggijakyaksan consisting of 6 herbes of paeoniae radix (2 g), poria cocos (1.33 g), angelicae sinensis radix (1 g), cnidii rhizoma (1 g), atractylodis macrocephalae rhizoma (1.33 g) and alismatis rhizoma (1.66 g), was studied. in this study, the mechanism involved in the antiplatelet activity of djs in ...200314686798
over-the-counter sleeping pills: a survey of use in hong kong and a review of their constituents.this study examined the composition of over-the-counter (otc) sleeping pills in hong kong and reviewed the current knowledge about the hypnotic efficacy and safety of their major herbal and dietary supplement constituents. we conducted a cross-sectional survey of otc sleep aids at drug stores in a residential district of 0.3 million population and literature search using medline, embase, psycinfo, china journal net, china biomedical database and relevant english and chinese literature. we identi ...200212490346
evaluation of herbal formulas by pulse analysis distinguish the component difference between two similar herbal formulas by pulse analysis method. many chinese herbs were found to have specific effects on the fourier components of the blood pressure pulse; it might infer a specific blood redistribution process on the body and reflect the health conditions of specific organs or tissues. the pulse effect of an herbal formula was similar to the linear combination of all its herbal compositions.200312546722
[immunological study on the antitumor effects of fungus polysaccharides compounds].fungus polysaccharides compounds (fpc) are the mixture of procyanidins oligomers, glycyrrhetinicacid and polysaccharides of hericium erinaceus, lentinus edodes and poria cocos. the antitumor effects of fpc and its immunity regulating effects as an immunostimulant on the mice burdened with sarcoma 180 (s-180) were studied. fpc (100, 200 and 400 mg/kg bw) was gavaged to mice for 31 days. s-180 was transplanted to these mice on the 21th day. lentinus edodes group was gavaged 200 mg/kg bw saccharine ...200012725070
a water-extract of the korean traditional formulation geiji-bokryung-hwan reduces atherosclerosis and hypercholesteremia in cholesterol-fed rabbits.geiji-bokryung-hwan (gbh), a drug preparation consisting of five herbs of cinnamomi ramulus (geiji), poria cocos (bokryun), mountan cortex radicis (mokdanpi), paeoniae radix (jakyak) and persicae semen (doin), is a traditional korean herbal medicine that is widely used in the treatment of atherosclerosis-related disorders. a water extract of gbh was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (dpph) radicals and inhibit low-density lipoprotein (ldl) oxidation more effectively than probucol, ...200312757741
a new antitumor polysaccharide from the mycelia of poria cocos wolf. 19836883606
chemical components and molecular mass of six polysaccharides isolated from the sclerotium of poria cocos.six polysaccharides were extracted sequentially from the fresh sclerotium of poria cocos cultivated in china using 0.9% nacl (pcs1), hot water (pcs2), 0.5m naoh (pcs3-i and pcs3-ii), and 88% formic acid (pcs4-i and pcs4-ii). their chemical and physical characteristics were determined using infrared spectroscopy (ir), gas chromatography (gc), gc-ms methylation analysis, 13c nmr spectroscopy, elementary analysis (ea), protein analysis, size exclusion chromatography combined with laser light scatte ...200414698891
dehydrotrametenonic acid and dehydroeburiconic acid from poria cocos and their inhibitory effects on eukaryotic dna polymerase alpha and beta.a new lanostane-type triterpene acid, (20xi)-3-oxolanosta-7,9(11),24-trien-21-oic acid (1; dehydrotrametenonic acid), along with a known triterpene acid, dehydroeburiconic acid (2), were isolated from the epidermis of the sclerotia of poria cocos. the structure of 1 was analyzed on the basis of spectroscopic methods. compounds 1 and 2 inhibited calf dna polymerase alpha and rat dna polymerase beta, with the 50% inhibition values of 45.5 microm (1) and 40.8 microm (2), and 86.5 microm (1) and 30. ...200414981314
[study on hplc fingerprint of the triterpene acids in poria cocos].to establish a method for hplc fingerprint determination of the triterpene acids in poria cocos.200212776555
the antiplatelet activity of geiji-bokryung-hwan, korean traditional formulation, is mediated through inhibition of phospholipase c and inhibition of txb(2) synthetase activity.geiji-bokryung-hwan (gbh), consisting of herbes of cinnamomi ramulus (geiji), poria cocos (bokryun), mountan cortex radicis (mokdanpi), paeoniae radix (jakyak), and persicae semen (doin), on antiplatelet activity in human platelet suspensions was studied. the mechanism involved in the antiplatelet activity of gbh in human platelet suspensions was investigated. gbh did not significantly affect the thromboxane synthetase activity of aspirin-treated platelet microsomes and gbh (15 and 30 microg/ml) ...200312810354
effect of culture media on the chemical and physical characteristics of polysaccharides isolated from poria cocos mycelia.mycelia of a wild strain poria cocos were cultured in two media differing in one constituent: bran extract or corn steep liquor, and are designated as wb and wc, respectively. six polysaccharide fractions were isolated sequentially from the two mycelia by 0.9% nacl (pcm1), hot water (pcm2), 0.5 m naoh (pcm3-i and -ii) and 88% formic acid (pcm4-i and -ii). their chemical and physical characteristics were determined by infrared spectroscopy (ir), gas chromatography (gc), 13c nmr, light scattering ...200312829396
antitumor activities of heteropolysaccharides of poria cocos mycelia from different strains and culture media.ten water-soluble heteropolysaccharide fractions were isolated from poria cocos mycelia cultured from one wild and one cultivated strain in two identical culture media differing only in one component: either corn steep liquor or bran extract. the chemical compositions, including monosaccharide profile, protein content, and molecular mass m(w) of the mycelial polysaccharides were determined. both the in vitro and in vivo antitumor activities of the heteropolysaccharides were evaluated and compare ...200312829397
polysaccharide isolated from poria cocos sclerotium induces nf-kappab/rel activation and inos expression in murine macrophages.we show that pcsc, a polysaccharide isolated from the sclerotium of poria cocos with 1% sodium carbonate, significantly induces nitric oxide (no) production and inducible no synthase (inos) transcription through the activation of nuclear factor-kappab/rel (nf-kappab/rel). in vivo administration of pcsc induced no production by peritoneal macrophages of b6c3f1 mice. pcsc also dose-dependently induced the production of no in isolated mouse peritoneal macrophages and raw 264.7, a murine macrophage- ...200312946432
biologically active compounds from aphyllophorales (polypore) fungi.this review describes biologically active natural products isolated from aphyllophorales, many of which are known as polypores. polypores are a large group of terrestrial fungi of the phylum basdiomycota (basidiomycetes), and they along with certain ascomycota are a major source of pharmacologically active substances. there are about 25 000 species of basidiomycetes, of which about 500 are members of the aphyllophorales, a polyphyletic group that contains the polypores. many of these fungi have ...200414987072
effects of the geiji-bokryung-hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of hepg2 and hep3b.we investigated the effects of a korean traditional prescription, geiji-bokryung-hwan (gbh) consisting of five herbs of cinnamomi ramulus (korean name geiji), poria cocos (bokryung), moutan cortex radicis (modanpi). paeoniae radix (jakyak) and persicae semen (doin) on tumor growth-inhibitory activity and cancer chemopreventive activity in assays representing three major stages of carcinogenesis. effects of the gbh extracts on carrageenan-induced edema inflammation using female (c57bl/6xc3h) f1 ( ...200415106735
pap 9704, a korean herbal medicine attenuates methamphetamine-induced hyperlocomotion via adenosine a2a receptor stimulation in mice.the effect of pap 9704, a traditional prescription in korea consisting of polygala tenuifolia, acorus gramineus, and poria cocos at a ratio of 1:1:1 (dry weight), on methamphetamine (ma)-induced hyperlocomotion was examined in mice. the increased locomotor activity induced by ma (1 mg/kg/d, i.p. x 7) was significantly attenuated by co-administration with pap 9704 (100 or 200 mg/kg/d, p.o. x 7) in a dose dependent manner. consistently, it was found that the hyperlocomotor activity occurred in par ...200415187444
anti-rejection effect of ethanol extract of poria cocos wolf in rats after cardiac allograft implantation.a living fetus within the maternal uterus provides an example of allogene tolerance in mammals. poria cocos wolf is the main component of many chinese medicinal combination drugs that have therapeutic effects on recurrent spontaneous abortion and that can maintain pregnancy until delivery. it was hypothesized that this herbal medicine can also prolong allograft survival after organ transplantation. here, in an in vivo study, we report the anti-rejection effect of the ethanol extract of poria coc ...200415198902
antioxidant activity of qizhu study the antioxidant, activity of qizhu tang (qzt) both in vivo and in vitro.200011603290
polysaccharide isolated from poria cocos sclerotium induces nf-kappab/rel activation and inos expression through the activation of p38 kinase in murine our previous studies, we showed that pcsc, a polysaccharide isolated from poria cocos, activated macrophages to induce the translocation of nf-kappab/rel into nucleus and dna binding to its cognate site in the promoter of inos gene [int. immunopharmacol. 3 (2003) 1353]. in the present study, we investigated the role of p38 kinase pathway and membrane receptors (cd14, toll-like receptor 4 (tlr4), and cr3) in mediating nitric oxide (no) production and nf-kappab/rel activation induced by pcsc. t ...200415222977
determination of the effectiveness of components of the herbal medicine toki-shakuyaku-san and fractions of angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test.the improving effects of various components of toki-shakuyaku-san (tss) and fractions isolated from angelica acutiloba radix (toki) on scopolamine-induced spatial memory impairment were investigated in eight-armed radial maze. the scopolamine-induced memory impairment was characterized by prominent increase of error choices in addition to decreased correct choices. toki, cnidium officinale rhizoma (senkyu), poria cocos hoelen (bukuryo), alisma orientale rhizoma (takusha), and atractylodes lancea ...200415351791
cytotoxicity and dna topoisomerases inhibitory activity of constituents from the sclerotium of poria cocos.the bioactivity-guided fractionation of the methylene chloride extract of the sclerotium of poria cocos led to the isolation of (s)-(+)-turmerone (1), ergosterol peroxide (2), polyporenic acid c (3), dehydropachymic acid (4), pachymic acid (5), and tumulosic acid (6). compounds 4-6 exhibited moderate cytotoxicities, with ic50 values of 20.5, 29.1, and 10.4 microm, respectively, against a human colon carcinoma cell line. however, 3-6 not only showed inhibitory activities as potent as etoposide us ...200415460443
inhibitory effect of gbh on platelet aggregation through inhibition of intracellular ca2+ mobilization in activated human platelets.geiji-bokryung-hwan (gbh) was studied on antiplatelet activity in human platelet suspensions. gbh consists of the 5 herbs cinnamomi ramulus, poria cocos, mountan cortex radicis, paeoniae radix, and persicae semen, which have been used in herbal medicine for thousands of years for atherosclerosis. the mechanism involved in the antiplatelet activity of gbh in human platelet suspensions was investigated. gbh inhibited platelet aggregation and ca2+ mobilization in a concentration-dependent manner wi ...200415474558
correlation of structure to antitumor activities of five derivatives of a beta-glucan from poria cocos sclerotium.a water-insoluble (1-->3)-beta-d-glucan isolated from fresh sclerotium of poria cocos was, respectively, sulfated, carboxymethylated, methylated, hydroxyethylated, and hydroxypropylated, to afford five water-soluble derivatives. their weight-average molecular masses (mw) and intrinsic viscosities ([eta]) were determined by size-exclusion chromatography combined with laser light scattering (sec-lls), lls, and viscometry in phosphate buffer solution (pbs) at 37 degrees c. the antitumor activities, ...200415476718
screening of korean herbal medicines used to improve cognitive function for anti-cholinesterase activity.methanolic extracts of seven herbs (acorus calamus, acorus gramineus, bupleurm facaltum, dioscorea batatas, epimedium koreanum, poria cocos and zizyphi jujuba) used in traditional korean medicine for improvement of memory and cognition in old age were tested for cholinesterase inhibitory properties using the ellman colorimetric method. significant inhibition of the enzyme at 200 microg/ml was observed for extracts from a. calamus and e. koreanum. the possible bases for the reputation of these an ...200415500267
assessment of anti-inflammatory activity of poria cocos in sodium lauryl sulphate-induced irritant contact the present study, we evaluated the anti-inflammatory activity of poria cocos (poco) on experimentally induced irritant contact dermatitis (icd) in a repeated sodium lauryl sulphate (sls) irritation model.200617026651
triterpene acids from poria cocos and their anti-tumor-promoting effects.the structures of six new lanostane-type triterpene acids isolated from the epidermis of the sclerotia of poria cocos were established to be 15alpha-hydroxydehydrotumulosic acid (5), 16alpha,25-dihydroxydehydroeburicoic acid (9), 5alpha,8alpha-peroxydehydrotumulosic acid (10), 25-hydroxyporicoic acid h (11), 16-deoxyporicoic acid b (12), and poricoic acid cm (16) on the basis of spectroscopic methods. on evaluation of these six and 11 other known triterpene acids isolated from the sclerotium, 1- ...200717488130
a novel dna topoisomerase inhibitor: dehydroebriconic acid, one of the lanostane-type triterpene acids from poria cocos.traditional chinese medicinal plants are a treasure house for screening novel inhibitors of dna polymerases and dna topoisomerases from mammals; in the present study, nine lanostane-type triterpene acids were found in sclerotium of poria cocos. among the nine compounds, only dehydroebriconic acid could potently inhibit dna topoisomerase ii (topo ii) activity (ic(50) = 4.6 microm), while the compound moderately inhibited the activities of dna polymerases alpha, beta, gamma, delta, epsilon, eta, i ...200415072595
antiproliferative and differentiating effects of polysaccharide fraction from fu-ling (poria cocos) on human leukemic u937 and hl-60 cells.poria cocos (pc), fu-ling, is an oriental fungus and has been widely used as a chinese traditional herbal medicine for centuries. in the present study, a neutral polysaccharide fraction from pc (pc-ps) was isolated by a series of chromatographies and its effects on antiproliferation and differentiation of human leukemic cells, u937 and hl-60, were investigated in vitro. results showed that the molecular weight of isolated pc-ps was approximately 160 kda, as estimated by gel permeation chromatogr ...200415046822
[triterpenes isolated from poria cocos by derivazations].the separation of triterpene acids was achieved from poria cocos (schw.) wolf by tlc after treatment with ph2cnn or rx under mild condition followed by selective hydrolysis of ester groupings. three triterpene acids, 3 beta-acetoxyl-16 alpha-hydroxy-lanosta-8,24(31)-diene-21-oic acid (i), 3-oxo-16 alpha-hydroxy-lanosta-7,9(11), 24(31)-trien-21-oic acid (ii) and 3 beta, 16 alpha-dihydroxylanosta-7,9(11), 24(31)-trien-21-oic acid (iii) were isolated.200212583173
response of wolfiporia cocos to iron availability: alterations in growth, expression of cellular proteins, fe3+-reducing activity and fe3+-chelators production.the main objective of this study was to evaluate the behaviour of the brown-rot fungus wolfiporia cocos under differential iron availability.200817850312
[the experimental research of atractylodes macrocephala and poria cocos on the meridian tropism theory in animals].the research was designed to study the meridian tropism theory of traditional chinese drug through experiments in animals.200415656143
antioxidant activities of some common ingredients of traditional chinese medicine, angelica sinensis, lycium barbarum and poria cocos.the antioxidant activities of three popular ingredients of traditional chinese medicine, namely angelica sinensis (as), lycium barbarum (lb) and poria cocos (pc) were evaluated in this study. the results showed that aqueous extracts of these crude drugs exhibited antioxidant activities in a concentration-dependent manner. all extracts displayed an inhibitory effect on fecl2-ascorbic acid induced lipid peroxidation in rat liver homogenate in vitro, with the order of activity lb > as > pc. the tes ...200415742346
dehydrotrametenolic acid selectively inhibits the growth of h-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway.the screening of natural products that preferentially inhibit growth of h-ras transformed rat2 cells vs. rat2 cells was performed to identify h-ras specific growth inhibitor. a lanostane-type triterpene acid, dehydrotrametenolic acid (3beta-hydroxylanosta-7,9(11),24-trien-21-oic acid), was isolated from the sclerotium of poria cocos (polyporaceae). dehydrotrametenolic acid selectively inhibited the growth of h-ras transformed cells with a gi(50) value of 40 microm. facs analysis indicated that t ...200616112686
herbal formula fbd extracts prevented brain injury and inflammation induced by cerebral ischemia-reperfusion.the aim of this work was to verify neuroprotective and anti-inflammatory properties of fbd, a herbal formula composed of poria cocos, atractylodes macrocephala and angelica sinensis, in icr mice subjected to repetitive 10 min of common carotid arteries occlusion followed 24 h reperfusion. intragastrical pretreatment with supercritical carbon dioxide extract (fbd-co(2), 37.5 mg/kg) twice daily for 3.5 d, significantly reduced evans blue influx, neuron specific enolase (nse) efflux, brain infarcti ...200818486376
antioxidant and antiplatelet effects of dang-gui-shao-yao-san on human blood cells.dang-gui-shao-yao-san (dgsys) is a mixture of medicinal herbs, which has long been used in traditional chinese medicine for treating anemia and ovulary disorders. its preparation comprises angelicae sinensis (oliv.) diels, ligustucum chuanxiong hort, paeonia lactiflora pall, poria cocos (schw.) wolf, atractylodis macrocephala koidz and alisma orientalis (sam.) juzep. the present study examined the anti-superoxide formation, free radical scavenging and anti-lipid peroxidation activities of dgsys ...200516265987
induction of apoptosis in prostate cancer cells by pachymic acid from poria cocos.pachymic acid (pa) is a natural triterpenoid known to inhibit the phospholipase a2 (pla(2)) family of arachidonic acid (aa)-producing enzymes. pla(2) is elevated in prostatic adenocarcinoma and conversion of aa to prostaglandins leads to akt pro-survival activity. in this study, we investigated the effect of pa on the growth of human prostate cancer cells. pa significantly reduced cell proliferation and induced apoptosis in a dose- and time-dependent fashion, with androgen-insensitive du145 pros ...200515913545
neuroprotective effect of a chuk-me-sun-dan on neurons from ischemic damage and neuronal cell toxicity.chukmesundan (cmsd), composed of the following 8 medicinal herbs including panex ginseng c.a. meyer, atractylodes macrocephala koid, poria cocos wolf, pinellia ternata breit, brassica alba boiss, aconitum carmichaeli debx, cynanchum atratum bge and cuscuta chinensis lam. cmsd is being used in korea for the treatment of various symptoms accompanying hypertension and cerebrovascular disorders. this study was carried out to examine the effects of cmsd on cultured primary neuron cell, cell cytotoxic ...200616474991
nematicidal activity and chemical component of poria cocos.poria cocos, a famous traditional chinese medicine, was found to have nematicidal activity in experiments searching for nematicidal fungi. the experiment showed it could kill 94.9% of the saprophytic nematode, panagrellus redivivue, 92.6% of the root-knot nematode, meloidogyne arenaria, and 93.5% of the pine nematode, bursaphelenchus xylophilus, on pda plate within 12 hours. according to the nematicidal activity, three new compounds, 2, 4, 6-triacetylenic octane diacid, 2, 4, 5, 6-tetrahydroxyhe ...200515765052
dietary fibers from mushroom sclerotia: 2. in vitro mineral binding capacity under sequential simulated physiological conditions of the human gastrointestinal tract.the in vitro mineral binding capacity of three novel dietary fibers (dfs) prepared from mushroom sclerotia, namely, pleurotus tuber-regium, polyporous rhinocerus, and wolfiporia cocos, to ca, mg, cu, fe, and zn under sequential simulated physiological conditions of the human stomach, small intestine, and colon was investigated and compared. apart from releasing most of their endogenous ca (ranged from 96.9 to 97.9% removal) and mg (ranged from 95.9 to 96.7% removal), simulated physiological cond ...200516302754
dietary fibers from mushroom sclerotia: 3. in vitro fermentability using human fecal microflora.the in vitro fermentability of three novel dietary fibers (dfs) prepared from mushroom sclerotia, namely, pleurotus tuber-regium, polyporous rhinocerus, and wolfiporia cocos, was investigated and compared with that of the cellulose control. all df samples (0.5 g each) were fermented in vitro with a human fecal homogenate (10 ml) in a batch system (total volume, 50 ml) under strictly anaerobic conditions (using oxygen reducing enzyme and under argon atmosphere) at 37 degrees c for 24 h. all three ...200516302755
growth-inhibitory effects of a beta-glucan from the mycelium of poria cocos on human breast carcinoma mcf-7 cells: cell-cycle arrest and apoptosis induction.because of the reported immune-enhancing and anti-tumor activities of some mushroom polysaccharides, their applications as biological response modifiers have attracted significant attention. we have purified a water-soluble beta-glucan pcm3-ii, comprising mainly 1right curved arrow 3 and 1right curved arrow 4 linkages, from the mycelia of poria cocos (schw.) wolf (fu-ling). in this study, the growth-inhibitory effect of pcm3-ii was further explored on the human breast carcinoma mcf-7 cells in vi ...200616465424
cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from poria cocos.a new lanostane-type triterpene, 29-hydroxypolyporenic acid c (8), was isolated from the dried sclerotia of poria cocos together with eight other known compounds pachymic acid (1), dehydropachymic acid (2), 3-acetyloxy-16alpha-hydroxytrametenolic acid (3), polyporenic acid c (4), 3-epi-dehydropachymic acid (5), 3-epi-dehydrotumulosic acid (6), tumulosic acid (7), and dehydrotumulosic acid (9). the compounds were identified by spectral analysis and comparison with spectroscopic data reported in t ...200818827390
poriacosones a and b: two new lanostane triterpenoids from poria cocos.two new lanostane triterpenoids, poriacosones a (8) and b (9), together with eight known compounds were isolated from the sclerotia of poria cocos (schw.) wolf (polyporaceae), and identified by spectroscopic analysis, including ir, uv, cd, esi-tof-ms, hr-sims, 1d-, and 2d-nmr spectra. the structures of the new compounds were established as 3alpha,16alpha-dihydroxy-24-oxolanost-7,9(11)-dien-21-oic acid (8) and 3beta,16alpha-dihydroxy-24-oxolanost-7,9(11)-dien-21-oic acid (9).200818636376
tumor initiation inhibition through inhibition cox-1 activity of a traditional korean herbal prescription, geiji-bokryung-hwan, in human hepatocarcinoma cells.some korean and oriental herbal prescriptions used for a syndrome expressed as chest paralysis and heartache are thought to be effective for angina pectoris. we investigated the effects of an oriental medicinal prescription, geiji-bokryung-hwan (gbh) consisting of herbs of cinnamomi ramulus, poria cocos hoelen (pachymae fungus), moutan cortex radicis, paeoniae radix, and persicae semen, on growth-inhibitory activity and cancer chemopreventive activity in assays representing three major stages of ...200516237957
neuroprotective effect of chuk-me-sun-dan on nmda- and ampa-evoked nitric oxide synthase activity in mouse brain.chukmesundan (cmsd) is composed of 8 medicinal herbs including panex ginseng c.a. meyer, atractylodes macrocephala koid, poria cocos wolf, pinellia ternata breit, brassica alba boiss, aconitum carmichaeli debx, cynanchum atratum bge, and cuscuta chinensis lam and used for the treatment of various symptoms accompanying hypertension and cerebrovascular disorders. this study was carried out to examine the effects of cmsd on n-methyl-d-aspartate (nmda)-evoked, and alpha-amino-3-hydroxy-5-methyl-4-is ...200516237959
targeting angiogenesis with integrative cancer integrative approach for managing a patient with cancer should target the multiple biochemical and physiological pathways that support tumor development while minimizing normal tissue toxicity. angiogenesis is a key process in the promotion of cancer. many natural health products that inhibit angiogenesis also manifest other anticancer activities. the authors will focus on natural health products (nhps) that have a high degree of antiangiogenic activity but also describe some of their many ot ...200616484711
[study on quality standard of poria cocos].to perfect the standard of poria cocos (schw.).200818661838
effects of triterpenoids from poria cocos wolf on the serotonin type 3a receptor-mediated ion current in xenopus oocytes.poria cocos wolf (p. cocos wolf) is used to treat chronic gastritis, edema, nephrosis, gastric atony, acute gastroenteric catarrh, dizziness, emesis and vomiting. triterpenoids are a class of natural compounds produced by p. cocos wolf that contain acyclic 30-carbon precursors. in this study, we investigated the effect of triterpenoids (pa, pachymic acid; da, dehydroeburicoic acid; ha, 3beta-hydroxylanosta-7,9(11),24-trien-21-oic acid) on human 5-hydroxytryptamine 3a (5-ht(3a)) receptor channel ...200919446542
molecular phylogeny of laetiporus and other brown rot polypore genera in north america.phylogenetic relationships were investigated among north american species of laetiporus, leptoporus, phaeolus, pycnoporellus and wolfiporia using its, nuclear large subunit and mitochondrial small subunit rdna sequences. members of these genera have poroid hymenophores, simple septate hyphae and cause brown rots in a variety of substrates. analyses indicate that laetiporus and wolfiporia are not monophyletic. all north american laetiporus species formed a well supported monophyletic group (the " ...200818751549
[medicinal interest of poria cocos (= wolfiporia extensa)].the sclerotium of poria cocos has been used in the chinese pharmacopoeia during thousands of years. in this note several aspects about the biology and nomenclature of this fungus are summarized, with emphasis on its composition and therapeutic applications.200919631158
anti-tumor-promoting effects of 25-methoxyporicoic acid a and other triterpene acids from poria cocos.nine new (1, 3, 5, 8, 12, 13, 15, 17, and 18) and nine known (2, 4, 6, 7, 9-11, 14, and 16) lanostane-type triterpene acids and a known diterpene acid (19) were isolated from the epidermis of the sclerotia of poria cocos. the structures of the new compounds were established as 16alpha,27-dihydroxydehyrotrametenoic acid (1), 25-hydroxy-3-epitumulosic acid (3), 16alpha,25-dihydroxyeburiconic acid (5), 25-methoxyporicoic acid a (8), 26-hydroxyporicoic acid dm (12), 25-hydroxyporicoic acid c (13), p ...200919746919
[absorption of triterpenoid compounds from indian bread (poria cocos) across human intestinal epithelial (caco-2) cells in vitro].to study the absorption of 3-epidehydrotumulosic acid (edhta), polyporenic acid c (ppac) and 6alpha-hydroxypolyporenic acid c (hppa) isolated from the sclerotium of poria cocos. in human intestinal epithelial.200818837324
chemical investigation on sijunzi decoction and its two major herbs panax ginseng and glycyrrhiza uralensis by lc/ms/ms.sijunzi decoction consists of panax ginseng, poria cocos, atractylodes macrocephala and glycyrrhiza uralensis. high performance liquid chromatography coupled with tandem mass spectrometry (lc/ms(n)) was applied to identify and characterize three types of active components, ginsenoside (from p. ginseng), flavonoid and triterpenoid (from g. uralensis) in sijunzi decoction. spectra of ms and ms/ms from [m+na](+) ions of ginsenosides were acquired and interpreted for their identification. fragmentat ...200616574366
immunopotentiation and anti-tumor activity of carboxymethylated-sulfated beta-(1-->3)-d-glucan from poria cocos.a carboxymethylated-sulfated derivative of (1-->3)-beta-d-glucan (pcs3-ii) extracted from poria cocos was synthesized and coded as cs-pcs3-ii. results of infrared (ir) and carbon-13 nuclear magnetic resonance spectroscopy ((13)c nmr) indicated that cs-pcs3-ii contained carboxymethyl and sulfate groups with a degree of substitution (ds) of 1.05 and 0.36 respectively. by using size exclusion chromatography (sec) combined with laser light scatting (lls), the dependence of radius of gyration (<s(2)> ...201020093198
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