TitleAbstractYear(sorted ascending)
line-of-descent and genealogical processes, and their applications in population genetics models.a variety of results for genealogical and line-of-descent processes that arise in connection with the theory of some classical selectively neutral population genetics models are reviewed. while some new results and derivations are included, the principle aim is to demonstrate the central importance and simplicity of genealogical markov chains in this theory. considerable attention is given to "diffusion time scale" approximations of such genealogical processes. a wide variety of results pertinen ...19846505980
use of an antifibrinolytic agent (tranexamic acid) and lateral sutures with laser conization of the hundred forty patients who underwent laser conization and 220 patients who underwent laser miniconizations were prospectively randomized into two study groups. one treatment group was given antifibrinolytic therapy in the form of tranexamic acid (cyklokapron, kabivitrum, sweden) intraoperatively and for 14 days postoperatively. the other group did not receive antifibrinolytic therapy. in the group of 68 patients with laser conizations who were given antifibrinolytic therapy, no postoperative ...19846384851
a stochastic numerical model of breast cancer growth that simulates clinical data.a new stochastic numerical model of breast cancer growth is developed. first, the model suggests that gompertzian kinetics does apply but that from time to time, in random fashion, there occurs a spontaneous change in the growth rate or rate of decay of growth, such that the overall growth pattern occurs in a stepwise fashion. according to the model, the average time for the tumor burden to increase from one cell to detection is probably in the range of 8 years. secondly, the model suggests that ...19846744323
differences in phosphorylation of the two large subunits of brine shrimp na,k-atpase.analysis of purified na,k-atpase from brine shrimp nauplii revealed two molecular forms of the alpha subunit separable by sodium dodecyl sulfate-polyacrylamide gel electrophoresis [g.l. peterson, r.d. ewing, s.r. hootman, and f.p. conte (1978) j. biol. chem. 253:4762]. the molecular form with lower mobility is designated alpha 1 and the one with higher mobility, alpha 2, in a neutral or alkaline gel system. differences in na+-dependent, k+-sensitive phosphorylation of these two molecular forms h ...19846094698
an interview with: richard fisher. 198410267831
the pacing stress test: a reexamination of the relation between coronary artery disease and pacing-induced electrocardiographic changes.electrocardiographic (ecg) changes during graded pacing-induced tachycardia have been considered unreliable as a test for the presence of coronary artery disease (cad) because of poor sensitivity and specificity. as a result, atrial pacing has not been widely used as an alternative to exercise testing. however, the limited value of the pacing stress test may be related to technical aspects, such as the duration of pacing and ecg monitoring. to study this problem, 22 patients undergoing coronary ...19846741838
miller fisher syndrome: clinical and electrophysiologic evidence of peripheral origin in 10 cases.clinical and electrophysiologic data recorded in patients with fisher syndrome characterized by ophthalmoplegia, ataxia, and areflexia are presented. cases with limb weakness or pleocytosis in the csf were excluded, according to fisher. ten patients were selected. all had hand and foot numbness. a large amount of protein without cell reaction was found during the third week of illness in serial csf examinations. emgs showed very slight limb involvement without spontaneous activity, and in most c ...19846539872
effects of n,n'-dicyclohexylcarbodiimide and n-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline on hydride ion transfer and proton translocation activities of mitochondrial nicotinamidenucleotide transhydrogenase.n,n'-dicyclohexylcarbodiimide (dccd) inhibits the mitochondrial energy-linked nicotinamidenucleotide transhydrogenase (th). our studies [phelps, d.c., & hatefi, y. (1981) j. biol. chem. 256, 8217-8221; phelps, d.c., & hatefi, y. (1984) biochemistry 23, 4475-4480] suggested that the inhibition site of dccd is near the nad(h) binding site, because nad(h) and competitive inhibitors protected th against inhibition by dccd and, unlike the unmodified th, the dccd-modified th did not bind to nad-agaros ...19846099137
on the apparent clustering of clonal albumin production and enzyme activity levels.this communication is a critique of a novel, but inappropriate, use of the correlation coefficient to demonstrate the clustering of biological activity levels about a purported geometric progression. the data are re-examined by using a fourier analysis approach to test for periodicity on a logarithmic scale; this approach follows from the methods of kendall (1974, philosophical transactions of the royal society, series a 276, 231-266) and fisher (1929, proceedings of the royal statistical societ ...19846534411
the doctor as patient: an encounter with guillain-bárré syndrome.the author describes the course and treatment of a severe acute illness that began with cranial nerve palsies and ataxia and progressed rapidly to generalized weakness with respiratory embarrassment. there was no sensory loss or elevation of the protein level in the cerebrospinal fluid. the miller fisher variant of guillain-barré syndrome was diagnosed. at the height of the illness, a period lasting about 2 weeks, the author was almost completely paralysed, retaining only a little motion in some ...19846388775
duaal processes in recognition and in recognition is argued that adherence of the results of experiments in the recognition failure paradigm to the function observed by tulving and wiseman (1975) reflects the operation of two distinct processes in recognition similar to those described by mandler (1979, 1980). familiarity decisions based on the target word alone can occur when target and list cue have not been integrated and result in some measure of dependence between recall and recognition. contextual retrieval can operate in recognition w ...198421287047
somatic antigens of pseudomonas aeruginosa. the structure of the o-specific polysaccharide chains of lipopolysaccharides of p. aeruginosa serogroup o4 (lányi) and related serotype o6 (habs) and immunotype 1 (fisher).acidic o-specific polysaccharides were isolated on mild acidic degradation of lipopolysaccharides of pseudomonas aeruginosa serotypes o4a,b, o4a,c, o4a,d (lányi classification) and serologically related to them serotype o6 (habs classification) and immunotype 1 (fisher classification). the polysaccharides had identical monosaccharide composition and were built up of l-rhamnose, 2-acetamido-2,6-dideoxy-d-glucose,2-formamido-2-deoxy-d-galacturonic acid and 2-acetamido-2-deoxy-d-galactouronamide re ...19852410275
effects of interferon on differentiation of normal and tumor described in this review, both partially purified and recombinant interferons are potent modulators of differentiation in diverse cell culture systems (table 2). depending on the target cell, interferon exerts either an inhibitory or an inductive effect on cell differentiation. in certain myeloid leukemic cells, such as hl-60, interferon by itself is growth suppressive but does not induce cell maturation, whereas in combination with inducers of differentiation, such as dmso, tpa or retinoic a ...19852412243
rat lung macrophage tumor cytotoxin production: impairment by chronic in vivo cigarette smoke exposure.macrophages in the presence of bacteria-derived lipopolysaccharide (lps) stimuli produce a soluble cytotoxin which is toxic to tumor cells. in this study, we examined various parameters of cytotoxin production from pulmonary lavage cells obtained from fisher 344 cesarean-derived rats. cultures of macrophages were derived from pulmonary lavage cells and stimulated in vitro with lps. cytotoxin production was assayed in vitro using an l-929 cell target assay. pulmonary lavage preparations contained ...19852413988
characteristics of normal rat mammary epithelial cells and n-ethyl-n-nitrosourea-induced mammary adenocarcinoma cells grown in culture.the characteristics of normal mammary epithelial cells derived from lewis and sprague-dawley rats and n-ethyl-n-nitrosourea (enu)-induced mammary gland adenocarcinoma cells derived from sprague-dawley (cd) and fisher (cdf) rats and grown in culture were compared. after collagenase treatment, the rat mammary epithelial cell aggregates were placed in a hormone-supplemented medium. the normal mammary epithelial cells (ne) attached to the surface of the dish within 50 hours, whereas the mammary aden ...19852415045
pausing of rna polymerase during in vitro transcription through the ilvb and ilvgeda attenuator regions of escherichia coli k12.synchronized single-round transcriptions, in vitro, from templates encoding the leader rna of the ilvb and ilvgeda operons result in the accumulation of a transcript consistent with rna polymerase pausing after the 1:2 stem that could form in each of the leader rnas. addition of l-factor or guanosine 5'-diphosphate,3-diphosphate extended the pause half-life obtained with the ilvb template; addition of l-factor and guanosine 5'-diphosphate,3'-diphosphate together had an additive effect on the pau ...19852578464
hepatocarcinogenic and promoting action of a choline-devoid diet in the rat.male fisher 344 rats were solely fed a choline-supplemented diet for 65 to 105 weeks or a choline-devoid diet for 24 to 102 weeks. hepatocellular carcinomas developed in the latter animals, beginning at 24 weeks. other groups of rats were given a single dose of 20 mg diethylnitrosamine/kg, 18 h after a partial hepatectomy and were fed, 4 weeks thereafter, either a choline-supplemented, or a choline-devoid diet for up to 48 weeks. in rats fed the choline-supplemented diet, the only relevant lesio ...19852859112
fiber number and type composition in extensor digitorum longus, soleus, and diaphragm muscles with aging in fisher 344 rats.histochemical (m-atpase) fiber typing was done on extensor digitorum longus, (edl), soleus (sol), and diaphragm (dia) muscles of barrier-reared fisher 344 rats obtained at four different ages (3, 9, 28, and 30 months) from the colonies of the national institute of aging. in the edl there are no differences in the percent of type i fibers among the four age groups. the percent of type iia and iib fibers also showed no difference between the 3 and 30 month age groups. there was no apparent trend f ...19852931475
dopaminergic modulation of the diethylstilbestrol-induced proliferation of the anterior pituitary gland of the fisher 344 rat.bromocriptine (cb 154), a potent agonist upon the d-2 receptor, blocks the proliferation of the mammotrophs and the elevation of serum prolactin concentration induced by chronic exposure of male fisher 344 rats to diethylstilbestrol (des). fluphenazine, a dopamine receptor antagonist, blocks these effects of cb 154. we conclude that a d-2 receptor occurs on the proliferating mammotroph of the male fisher 344 rat and that stimulation of this receptor inhibits prolactin release and stops the des-i ...19852932654
short- and long-term evaluation of normal and abnormal human thyroid cells in monolayer culture.we have investigated the tsh responsiveness of normal and abnormal human thyroid cells cultured in the short term with high serum concentrations and for up to 6 months in a low serum, chemically-defined, medium. cells from normal human thyroid tissue (n = 9), multinodular goitre (n = 6), benign follicular adenomata (n = 6), and differentiated thyroid carcinoma (n = 3) formed confluent monolayers which were sensitive to bovine tsh (btsh) in concentrations greater than 25 microu/ml when assessed b ...19853002667
testicular lh receptors during aging in fisher 344 rats.levels of serum lh, prolactin, testosterone, progesterone and 17-oh progesterone and the testicular concentration and total content of lh receptors were measured in 4-, 11-, 18-, and 27-month-old fisher 344 rats. all 27-month-old rats had leydig cell tumors. at first, testicular lh receptor levels decreased with age, but with the appearance of the testicular tumors, these levels increased dramatically. serum prolactin levels fluctuated with age, but were significantly decreased in 27-month-old r ...19852982778
stability and utility of the unique human small cell carcinoma line shp-77.the human small cell (oat cell) carcinoma line, shp-77, established by fisher and paulson in 1977 and originally described as a "large cell variant of oat cell cancer" has been evaluated by several different parameters and shown even after more than 200 passages to retain properties described for the original cell line. karyotypic, histological, and biochemical features are retained, as well as tumorigenicity in nude mice. the original authors' suggestion that this is a propitious cell line for ...19852985251
the simian virus 40 sequences between 0.169 and 0.423 map units are not essential to immortalize early-passage rat embryo cells.f8dl is a simian virus 40 early-region deletion mutant that lacks the sequences between 0.169 and 0.423 map units. we show that cloned f8dl dna immortalized early-passage fisher rat embryo cells with an efficiency that was about 20% of that of cloned wild-type simian virus 40 dna. in contrast, we detected no immortalized colonies when we transfected the cells with dna of five other early-region deletion mutants that do not make stable truncated forms of t antigen. since all five of these mutants ...19852987680
hepatic neoplastic nodules, adenofibrosis, and cholangiocarcinomas in male fisher 344 rats fed corn naturally contaminated with fusarium moniliforme.twelve male fisher 344 rats were fed corn naturally contaminated with fusarium moniliforme. this corn sample was obtained from feed being fed horses during an outbreak of leukoencephalomalacia. all rats necropsied from 123 to 176 days post feeding had multiple hepatic nodules and pale depressed hepatic areas. histological examination revealed multiple hepatic neoplastic nodules and large areas of adenofibrosis and cholangiocarcinomas. the corn only diet was deficient in many nutrients including ...19852990756
2,4-dichlorophenoxyacetic acid (2,4-d) does not cause polyneuropathy in the rat.2,4-dichlorophenoxyacetic acid (2,4-d), a component of agent orange, was injected intraperitoneally into adult male fisher rats for 3-12 weeks. during the period of study gait and toe-spreading reflexes remained normal and distal motor latencies, motor and mixed nerve conduction velocities and amplitudes remained similar (p greater than 0.05) in animals receiving 2,4-d or vehicle. this study suggests that 2,4-d is not toxic to peripheral nerves in the rat.19852997403
selective inhibition of leukotriene b4 biosynthesis in rat pulmonary alveolar macrophages by dietary selenium deficiency.weanling male fisher 344 rats were maintained on low selenium basal and se-supplemented diets for 38 weeks. a several fold reduction in the glutathione peroxidase activity of the lung and liver tissues in rats maintained on low se basal diet established their se-deficient status. analysis of the supernatants from resting pulmonary alveolar macrophage suspensions showed negligible extracellular release of pge2, txb2 and ltb4 in both diet groups. a challenge with opsonized zymosan particles increa ...19852998361
lambda phage cro repressor interaction with its operator dna: 2'-deoxy-5-fluorouracil or3 analogues.the experiments here show that chemically synthesized dna containing fluorine at selected sites can be used to test specific predictions of a model for cro repressor--operator interaction. this is done by observation of the perturbation to the fluorine-19 nmr spectra of analogues of or3 synthesized with 2'-deoxy-5-fluorouracil at specific positions in the dna helix. although the three-dimensional structure of the cro repressor from phage lambda has been determined by matthews and co-workers [and ...19853157402
the autologous mixed lymphocyte reaction is decreased in freund's adjuvant-injected rats of arthritis-susceptible and -insusceptible strains.we examined the t-non-t cell autologous mixed lymphocyte reaction (amlr) of spleen cells from rats with arthritis induced by freund's complete adjuvant in an effort to establish an animal model for the study of the relationship between the amlr and autoimmune disease. we found that the splenic t-non-t amlr was markedly decreased in rats with adjuvant-induced arthritis and that this decrease was mediated by suppressor cells within the nylon-wool-adherent stimulator cell population. however, we al ...19853159391
morphine dependence and protracted abstinence: regional alterations in cns radioligand binding.rats (fisher f-344) were given free access to a 10% sucrose solution containing 0.5 mg/ml morphine sulfate (controls received the sucrose vehicle only) as their sole source of fluid. daily morphine intake averaged 119 +/- 21 mg/kg, an amount sufficient to induce physical dependence. after 18 days on this regimen, the control and dependent subjects were sacrificed. a protracted abstinence group was weaned from morphine by reducing its concentration in the vehicle by 20% over the next 5 days, foll ...19853001786
co-carcinogenic effects of several korean foods on gastric cancer induced by n-methyl-n'-nitro-n-nitrosoguanidine in study i, 48 aci and fisher inbred rats were given mnng 100 micrograms/ml, with or without 1 per cent or 3 per cent red pepper diet; in study ii, 164 sprague-dawley rats given mnng 100 micrograms/ml, with or without 5 per cent or 10 per cent nacl; in study iii, 181 wistar rats given mnng 83 micrograms/ml with or without maejoo 10 gm per cent/diet; in study iv, 78 wistar rats given mnng 83 micrograms/ml with or without ginseng extract 150 micrograms/ml; in study v, 120 wistar rats given mnng 83 ...19853831496
intravenous self-administration of ethanol and acetaldehyde by rats.fisher strain rats were allowed to self-administer 2, 6, and 18 microm/kg/infusion of ethanol and acetaldehyde into the jugular vein for 22 to 28 days. thirty-three percent of the rats self-administered 18 microm/kg/infusion of ethanol. thirty-three, 40, and 33 percent of the rats initiated self-administration of 2, 6, and 18 microm/kg/infusion of acetaldehyde, respectively. it is suggested that acetaldehyde may possess stronger reinforcing effects than ethanol in intravenous self-administration ...19853832687
functional analysis of mononuclear cells infiltrating into tumors: differential cytotoxicity of mononuclear cells from tumors of immune and nonimmune rats.a million syngeneic gliosarcoma (t-9) cells injected subcutaneously are sufficient to kill fisher rats within 2 mo. fisher rats became resistant to t-9 cells by surgical removal of the implanted tumor and repeated immunization with mmc-treated t-9 cells. histopathologic studies revealed massive accumulation of mononuclear cells in tumor tissues of immune rats that were rejecting syngeneic t-9 tumors, whereas very few mononuclear cells were found in tumor tissues of nonimmune rats. cell populatio ...19853855260
[regional blood flow of experimental brain tumors with special reference to effects of chemotherapy and radiotherapy].regional blood flow and capillary permeability in the experimental brain tumors and their surrounding brain tissue of rats were measured with quantitative 14c-antipyrine and 14c-alpha-aminoisobutyric acid (aib) autoradiographic method. the pharmacokinetic implications with respect to drug delivery to tumor tissue and the effect of ionizing irradiation were discussed in these physiological measurement. a suspension of 1 x 10(4) rat glioma cells (e239 rg 12) was stereotactically implanted into the ...19853860212
a monoclonal antibody (gf 22.1) detecting different patterns of hla class i cross-reactivities at different dilutions.a murine cytotoxic monoclonal antibody (gf 22.1) was produced by balb/c immunization with gra human lymphoblastoid cells. hla-a, b and c blanketing and sds-page analysis of the immunoprecipitate demonstrated mhc class i structures as the targets. cytotoxic assays were performed with peripheral blood lymphocytes from 84 unrelated donors and from members of 15 families at different antibody dilutions. statistical analysis was performed by fisher test on each dilution separately and by mann-whitney ...19853863262
effect of age on fever and acute-phase response of rats to endotoxin and salmonella typhimurium.age-related effects on endogenous pyrogen-mediated febrile and acute-phase responses to endotoxin and salmonella typhimurium challenge were investigated in young adult and aged fisher 344 rats. after injection of endotoxin, the febrile response over 6 h and the fall in plasma iron and zinc after 6 h were determined in 14 young adult and 14 aged rats in their thermoneutral zone (26 degrees c) and in 14 young adult and 14 aged rats maintained in a cold environment (15 degrees c). although at 26 de ...19853880718
penetrating corneal transplantation in the inbred rat: a new model.a model of orthotopic penetrating keratoplasty has been developed in the inbred rat using both avascular and prevascularized recipient beds. the surgical procedure is conventional and can be achieved with standard instrumentation. isografts into avascular recipient beds (fisher 344 into fisher 344 strain combination) were successful and survived indefinitely with excellent corneal function judged either visually by clarity and lack of oedema, or histologically at autopsy. allografts into avascul ...19853881365
prodynorphin immunoreactivity is located in different neurons than proenkephalin immunoreactivity in the cerebral cortex of rats.reported here is a description of the distribution and cellular morphology of neurons containing dynorphin b immunoreactivity (ir) and a comparison with cells containing bovine adrenal medullary peptide ir in the cerebral cortex of colchicine treated rats. dynorphin b-ir was found in bipolar and multipolar cells in neocortical layers ii-iii and v-vi and in pyramidal and polymorph cells in olfactory cortical layers ii and iii. in the hippocampus, dynorphin b-ir was found in dentate granule cells ...19853889694
restriction of gut-derived endotoxin impairs dna synthesis for liver regeneration.the influence of restricting gut-derived endotoxin availability on liver regeneration after partial hepatectomy was evaluated. partial hepatectomy was performed by 67% liver resection of ether-anesthetized rats. liver regeneration was quantified after partial hepatectomy by [3h]thymidine incorporation into hepatic dna; endotoxemia due to absorption of endogenous endotoxin from the gut into the portal circulation was determined by qualitative lysate assay of perchloric acid-extracted plasma sampl ...19853904484
[levels of inorganic and organic substances in the femur of fisher rats treated with derivatives of vitamin d]. 19853917131
time course of induction of prolactin-secreting pituitary tumors with diethylstilbestrol in male rats: response of tuberoinfundibular dopaminergic neurons.3,4-dihydroxyphenylalanine (dopa) accumulation and dopamine (da) and noradrenaline levels were measured in the median eminence (me) of fisher 344-derived inbred male rats. these animals had been treated with silastic capsules containing 8-9 mg diethylstilbestrol (des) or with empty capsules for 3, 7, 14, or 30 days and had the pellets removed 22 days before killing. in an additional group of rats, the des pellets were continuously present until killing. blood was collected before treatment was s ...19853917247
the efficacy of total parenteral nutrition in malnourished tumor-bearing rats.the current study was designed to compare the efficacy of total parenteral nutrition (tpn), provided either before or after tumor removal, in replenishing protein stores in the malnourished tumor-bearing (tb) host. fisher 344 rats bearing a transplantable methylcholanthrene (mca)-induced sarcoma were used. after the animals were cachectic from their tumor, a central venous catheter was inserted. at the time of catheter insertion, the animals were randomized into two groups. group i rats had the ...19853918782
monoclonal antibodies prepared against the major drosophila nuclear matrix-pore complex-lamina glycoprotein bind specifically to the nuclear envelope in situ.a high molecular weight glycoprotein found associated with a nuclear matrix-pore complex-lamina (nmpcl) preparation obtained from drosophila melanogaster embryos has been shown by in vitro analyses to be largely confined to this subcellular fraction. in contrast with several of the nmpcl proteins, this glycoprotein remains completely insoluble after treatment with 5 m urea. it has, therefore, been possible to separate the glycoprotein from other nmpcl components by differential urea extraction. ...19853919018
presence of high affinity dopamine receptors in estrone-induced, prolactin-secreting rat pituitary adenomas: a model for human prolactinomas.adenomatous cells obtained from a pituitary tumor induced in fisher 344/lis rats by the subcutaneous implantation of estrone (e1) were found to secrete large amounts of prolactin (prl). the secretion of prl was stimulated by thyrotropin-releasing hormone (trh) and low concentrations of dopamine (da), while micromolar concentrations of da were inhibitory. high affinity binding sites for 3h-spiroperidol (3h-spir) were found to be present on the cells and to conform to the criteria of dopaminergic ...19853920132
polylactosamine glycosylation on human fetal placental fibronectin weakens the binding affinity of fibronectin to gelatin.gelatin-binding chymotryptic fragments from placental fibronectin contain polylactosamine carbohydrates (zhu, b.c.r., fisher, s.r., pande, h., calaycay, j. shively, j.e., and laine, r.a. (1984) j. biol. chem. 259, 3962-3970). we have separated polylactosamine-containing gelatin-binding fragments of placental fibronectin from their counterparts containing smaller "complex" n-linked saccharides using sephadex g-200 gel permeation chromatography. the peptide portions of both fragments have similar ...19853920213
delayed enzyme expression: a defect of aging rat evaluate the effect of aging upon the small intestine, the distribution, content, and concentration of epithelial cell enzymes at different levels along the crypt-villus column were measured in aging and young adult, male, fisher 344 rats. specific activities of sucrase, maltase, lactase, and adenosine deaminase in mucosal homogenates were lower in the upper intestines of aging than in young animals, whereas the specific activity and content of thymidine kinase was higher. enzyme activities w ...19853930340
the effect of parenteral nutrition on gastrointestinal immunity. the importance of enteral stimulation.secretory iga (s-iga), an immunoglobulin present in secretions, prevents the adherence of bacteria to mucosal cells and is the principle component of the gut mucosal defense system. the purpose of this study was to determine whether the route of nutrient administration affects s-iga. twenty-five female fisher rats were randomized into three groups. groups i and ii were fed an isonitrogenous, isocaloric standard hyperalimentation solution, group i intravenously and group ii via a gastrostomy. gro ...19853935061
residuals in multiple regression examination of residuals can be used as a technique to determine the best model for use in multiple-regression analysis. in addition to r2 and the fisher f ratio, a complete analysis of residuals has been used by statisticians for many years to estimate bias and to choose the best equation to fit physicochemical as well as biological and psychosociological data. however, residual analysis has seldom appeared in studies in pharmaceutics, pharmacology, or medicinal chemistry. this report gives ...19853935772
maternal epilepsy and birth defects: a case-control study in the italian multicentric registry of birth defects (ipimc).a case control study on the association between maternal epilepsy, anticonvulsants use during pregnancy and birth defects was carried out in the italian multicentric registry of birth defects (ipimc). in the period 1980-1983, 7,607 malformed babies out of 439,717 total births (still + live) were registered. fourty-one malformed babies with maternal epilepsy were identified (5.39 x 1,000). the overall relative risk of having a malformed baby among pregnant epileptic women was 1.87. spina bifida, ...19853939491
the effects of prolactin on rat testicular steroidogenic enzyme investigate whether hyperprolactinemia directly affects rat testicular steroidogenesis, we examined the effects of prolactin (prl) on microsomal 3 beta-hydroxysteroid dehydrogenase (3 beta-hsd) 17-hydroxylase (17-oh), 17,20-desmolase (17,20-d), 17-ketosteroid reductase (17-ksr) and aromatase enzyme activities. adult hypophysectomized, gonadotropin-treated fisher rats were rendered hyperprolactinemic by isografting pituitaries under the kidney capsule. the controls received skeletal muscle. al ...19853967847
effect of surgery on tumor-induced accelerated coagulation in a rat carcinoma.accelerated coagulation detected by thromboelastography has been reported in early stages of tumor growth. the present investigation was conducted to determine the changes in tumor-induced accelerated coagulation following complete and partial resection of the tumor. male fisher rats were divided into four groups: (1) control, (2) tumor-bearing rats, (3) complete resection, (4) partial resection. in groups 2, 3, and 4 a 2-mm3 piece of squamous cell carcinoma (nci 11095) was implanted subcutaneou ...19853968872
inhibitory effects of secretin on gastrin-stimulated rat colon neoplasms.a study was done to determine if continuous administration of exogenous secretin would inhibit the trophic effect of elevated endogenous gastrin on colon neoplasms in rats. colon tumors were induced in 37 fisher rats by subcutaneous injection of 1,2-symdimethylhydrazine, 20 mg/kg, weekly for 18 weeks. elevation of endogenous gastrin was achieved by antral exclusion surgery. control rats received a sham operation. subcutaneous osmotic minipumps delivered 35.5 u/kg/day of secretin for 7 days befor ...19853971292
approaches to prostatic cancer chemotherapy using the dunning r3327h prostatic adenocarcinoma.androgen-responsive cells: to determine if testosterone or dihydrotestosterone is the main trophic hormone of prostatic adenocarcinoma, we have treated dunning r3327h prostatic adenocarcinoma-bearing rats with 6-methylene progesterone, which blocks conversion of testosterone to dihydrotestosterone. copenhagen-fisher rats were treated with steroid (20 mg/kg daily) immediately following implantation of tumor and thereafter for 117 days. there was a 92% inhibition of growth of tumors and a lesser e ...19853975175
effects of phenobarbital and skf-525a on in vitro hepatic metabolism of verapamil and nifedipine.both verapamil and nifedipine are first-generation calcium-entry antagonist drugs which are eliminated by hepatic metabolism. to evaluate the effects of enzyme induction and suppression on the biotransformation of these compounds, liver homogenate fractions were prepared from male fisher (f344) rats, which were either untreated, or injected intraperitoneally with phenobarbital or with skf-525a prior to sacrifice. known concentrations of verapamil or nifedipine were incubated with the 9,000 g sup ...19853975261
lesions of articular, sternal and growth plate cartilage in rats.degenerative osteoarthritis was observed in the femur and sternum in specific pathogen free fisher 344 rats at 13 and 19 months of age. histological changes consisted of degeneration of the matrix and erosion in the articular cartilage of the femur. in the sternal cartilage, degeneration and necrosis of the matrix, formation of cysts, and cleft-like fractures were observed. in addition, degeneration of the matrix, appearance of eosinophilic streaking, and necrosis and fissure between the growth ...19853976132
reduced calcium uptake by rat brain mitochondria and synaptosomes in response to aging.synaptosomes were isolated from cerebral cortex of 3-, 18- and 24-month-old male, fisher 344 rats and 45ca2+ uptake was measured at 1, 3, 5, 15 and 30 s time periods following 65 mm kcl depolarization. identical experiments were performed in which 5 mm kcl was added to examine age-related changes in resting 45ca2+ accumulation by synaptosomes. both 'fast-' and 'slow-phase' voltage-dependent 45ca2+ uptake were significantly reduced in synaptosomes from 18- and 24- vs 3-month-old rats. no age-rela ...19853978439
measles outbreak in a pediatric practice: airborne transmission in an office february 1981, a measles outbreak occurred in a pediatric practice in dekalb county, ga. the source case, a 12-year-old boy vaccinated against measles at 11 1/2 months of age, was in the office for one hour on the second day of rash, primarily in a single examining room. on examination, he was noted to be coughing vigorously. seven secondary cases of measles occurred due to exposure in the office. four children had transient contact with the source patient as he entered or exited through the ...19853982900
effects of factors derived from a tumor clonal cell line on dna synthesis of transformed and non transformed cells.conditioned medium from neoplastic thyroid cell cultures, extracts of tumors developed by identical cells in isogeneic fisher 344 rats and serum from those tumor-bearing animals, were tested in pulse thymidine labelled experiments on a transformed and two non transformed cell lines. tumor extract and conditioned medium inhibited dna synthesis. tumor-bearing rat serum increased dna synthesis in a cerebellar transformed cell line, but no in chick embryo fibroblasts or in aorta non transformed cell ...19853986917
image analysis of gfa-positive astrocytes from adolescence to senescence.smears of fresh rat brain tissue combined with immunohistochemistry using antiserum to glial fibrillary acidic protein (gfa) were used to visualize individual astrocytes in different cortical regions of rats ranging in age from 1 to 30 months. by computerized image analysis, the cell area and the cell perimeter were determined. using 4-month-old male sprague-dawley rats, it was found that gfa-positive astrocytes from cerebellum and hippocampus were significantly larger, both in terms of cell are ...19853987847
effects of chronic bromocriptine treatment of an estrone-induced, prolactin-secreting rat pituitary adenoma.bromocriptine (brom), a dopamine (da) agonist, is commonly and successfully used for long-term treatment of human prolactinomas. we have studied the effects of chronic brom administration to female 344 fisher/lis rats bearing an estrone-induced, prolactin (prl)-secreting pituitary tumor recently characterized as a model for human prolactinoma. the animals were injected twice daily with brom (2.5 mg/kg) or with diluent. after 1 month of treatment, the animals were sacrificed, and plasma collected ...19853997065
a macrophage-mediated factor that increases the high energy phosphate content of skeletal muscle.a marked cellular infiltrate accompanies wounding. the phagocytic and bacteriocidal activities of this infiltrate require increased substrate and o2 consumption. this rapid utilization of available oxygen and substrates could jeopardize an already compromised resident cellular component of a wound. recent studies have demonstrated macrophage-mediated cell stimulatory agents which induce proliferation of nonlymphoid mesenchymal cells. this study was designed to examine macrophage-resident tissue ...19853999732
growth-depressing effects of alcohol and nicotine in two strains of rats.inbred buffalo and fisher rats were submitted to daily treatment with alcohol and nicotine for a period of 6 months. alcohol treatment was pre- and postnatal, nicotine treatment postnatal only. all parameters of bone length and weight were depressed in both experiments in spite of the continuous growth of the rats. although the level of depression was greater in some areas than in others, a clear target area applicable to both sexes and strains could not be found. fisher and buffalo females tole ...19854003023
macrophage interaction with skeletal muscle: a potential role of macrophages in determining the energy state of healing wounds.a decrease in atp and creatine phosphate (cp) is characteristic of local injury to skeletal muscle. recent data have suggested adequate potential for high-energy phosphate production in the wounded tissue. thus, an adequate explanation for the deficit in the high-energy tissue content in wounds was lacking. since the wound has multiple components (muscle + cellular infiltrate), the tissue content represents the summation of these components. therefore, a technique to separate these components wa ...19854020909
correlation of human bladder tumor recurrence with changes in clonogenicity of urothelial cells.over a 2-year period 340 cystoscopies were performed on 174 patients (126 men and 48 women) followed up for previously treated transitional cell tumor of the bladder or new cases suspected of having bladder tumor. bladder washings taken at cystoscopy in 66% yielded cells for clonogenic assay. patients with transitional cell tumors had an average clonogenic index (ci) of 14 (+/- 5) colonies per 10(5) viable urothelial cells, whereas previously tumorous patients with tumor-free bladders had an ave ...19854027894
in vivo and in vitro antiestrogenic action of 3-hydroxytamoxifen, tamoxifen and 4-hydroxytamoxifen.this study demonstrates in vivo and in vitro properties of the non-steroidal antiestrogens tamoxifen (tam), 4-oh-tamoxifen (4-oh-tam) and 3-oh-tamoxifen (k 060 e). in immature rabbit uteri 4-oh-tam and k 060 e bound to the respective estrogen receptors with a ten-fold higher affinity than tam. furthermore, k 060 e exhibited less agonistic (estrogenic) but higher antagonistic (antiestrogenic) activity in the immature rat uterus than tam and 4-oh-tam (change of uterine weight). the ratio of agonis ...19854043181
long-term consequences of cis-platinum-induced renal injury: a structural and functional study.previous studies have shown that a single dose of the antitumor drug, cis-platinum, causes renal cyst formation in rats 1-6 months after drug injection. this observation led to a further evaluation of the long-term effects of cis-platinum on the kidney of the rat. fisher 344 rats (n = 13) were given either a single intraperitoneal injection of cis-platinum (6 mg/kg body weight) or saline (control) and 15 months later renal function and pathology were assessed. the glomerular filtration rate and ...19854061878
post-partum antibody-dependent cell-mediated immunity in the rat following perinatal exposure to iodine-131.a study was recently completed which indicated the first generation of adult rats that had been exposed perinatally to iodine-131 possessed peripheral blood lymphoid-cells capable of expressing cytotoxicity towards cultured small bowel adenocarcinoma target cells, i.e., active antitumor cell-mediated immunity (cmi). the results gathered during the current investigation suggest that such animals similarly express anti-tumor antibody-dependent cell-mediated immunity (adcc). the animal model employ ...19854062256
arousal deficit shown in aged rat's quantitative eeg and ameliorative action of pramiracetam compared to piracetam.the basal eeg profile of the aged fisher-344 rat was consistently different from that of the young rat, showing dominant high voltage slow-wave components. these slow waves were present in both the frontal cerebral cortex and dorsal hippocampus. absent or greatly attenuated in the aged rat's hippocampal eeg was rhythmic theta activity, which was always dominant in the young awake rat's hippocampus. these eeg differences were clearly apparent only under basal test conditions, i.e., following habi ...19854065299
a walker 256 tumor-induced osteogenic small animal model for the evaluation of [99mtc] diphosphonate radiopharmaceuticals.a mammalian model has been developed for the in vivo evaluation of bone imaging agents. the model is based upon the quantification of a discrete, initial secondary periosteal osteogenesis induced in cortical bone immediately adjacent to an intramuscularly implanted walker 256 tumor in fisher 344 rats. evaluation of the model consists of a histopathological examination of the periosteal bone formation, biodistribution studies on 99mtc-mdp and 99mtc-hmdp commercial kit preparations, and biodistrib ...19854066198
modification of experimental gentamicin nephrotoxicity by selective parathyroidectomy.dietary calcium loading reduces gentamicin nephrotoxicity in rats. since parathyroid hormone increases renal brush border membrane anionic phospholipids, the putative gentamicin receptors, the effects of selective parathyroidectomy on gentamicin nephrotoxicity were examined. male fisher 344 rats underwent parathyroidectomy or sham surgery. all animals were fed a diet containing 0.5% calcium for 2 wk prior to gentamicin, 20 mg/kg twice daily for 6 and 10 days. other parathyroidectomized rats were ...19854073266
comparison of the energetics of the uncatalyzed and glutamate dehydrogenase catalyzed alpha-imino acid-alpha-amino acid interconversion.the thermodynamic and activation parameters for the reduction of delta 1-pyrroline-2-carboxylic acid (an alpha-imino acid) by reduced nicotinamide adenine dinucleotide phosphate (nadph) are compared with those for the reduction of the same imino acid by the glutamate dehydrogenase-nadph complex. the enthalpies of activation and standard free energy changes for these two reactions are found to be virtually the same. the catalysis by the enzyme, expressed as the ratio of the reactivity of the enzy ...19854074700
an all-glass perfusator for investigation of the intestinal transport and metabolism of foreign compounds in vitro.the in vitro perfusion technique of surviving intestinal segments as described by fisher and parsons (1949) and modified by rummel and stupp (1960) was further improved by the introduction of an all-glass perfusator for studying the intestinal transport and metabolism of lipophilic xenobiotics.19854079445
tyrosine motions in relation to the ferric spin equilibrium of cytochrome p-450cam.second derivative spectroscopy was used to determine the percentage of tyrosine residues that are exposed to solvent in cytochrome p-450cam isolated from pseudomonas putida. the ratio between two peak to trough second derivative absorbance differences has been shown to be dependent on the polarity of the microenvironment surrounding tyrosine residues [ragone, r., colonana, g., balestrieri, c., servillo, l., & irace, g. (1984) biochemistry 23, 1871]. with a number of camphor analogues that indepe ...19854084552
strain differences and laminar localization of structural neurochemical changes in aging obtain comparisons of age-related microchemical changes in cerebral cortex of two commonly employed rat strains (fischer 344 and sprague-dawley), neurochemical assays of substances regarded as quantitative indices of structural entities in brain were performed. these included dna as a marker for cells, lipid sialoganglioside as an index of neuronal membrane mass, and galactocerebroside as an index of myelin. fischer 344 rats were studied at 3-4 months (young), 14-16 months (middle age) and 25 ...19854088423
[cerebral lymphoma associated with lesions of multiple sclerosis].a 24 year-old man experienced a left retrobulbar neuritis which improved completely after 2 months of non-steroid antiinflammatory therapy. one month after the end of the treatment he developed a korsakoff-like amnestic syndrome. three months later he complained of horizontal diplopia. a ct scan showed a diffuse enhancement of the periventricular areas, corpus callosum and fornix. diplopia and ct scan abnormalities disappeared after the administration of tetracosactide. subsequently a progressiv ...19854089407
ntp toxicology and carcinogenesis studies of diallylphthalate (cas no. 131-17-9) in f344/n rats (gavage studies).diallylphthalate is widely used as a crosslinking agent for unsaturated polyesters. diallylphthalate or diallylphthalate polyester blends are used primarily as plasticizers and carriers for adding catalysts and pigments to polyesters and in molding, electrical parts, laminating compounds, and impregnation of metal castings. rubber compounds, epoxy formulations, and polyurethane foams may also contain diallylphthalate. precise figures are not currently available, although annual production of dia ...198512748696
[chromosome analysis of female baboons following treatment with sts 557 and levonorgestrel].adult, female baboons (papio hamadryas) were administered orally once 18 h p.c., either 1.6 mg sts 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4;9(10)-dien-3-one) or 1.6 mg levonorgestrel. investigations of the bone-marrow cells of these animals showed, compared to untreated controls, no signs of increased chromosome aberrations caused by the substances. the relative frequency of chromosome aberrations were estimated for controls: sts 557: levonorgestrel with 0.60 +/- 0.35 : 0.55 +/- 0.39 : ...19853922162
the evolution of dominance: haldane v fisher revisited.fisher's model for the evolution of dominance indicates that the accumulation of dominance modifiers will be accelerated by (1) an increased frequency of the mutant heterozygote, (2) increased selection for the phenotype of the normal homozygote. the model has been criticised by haldane on the grounds that point (1) is not fulfilled, that is dominance appears to be more common in populations with a low frequency of mutant heterozygotes (populations of inbreeders). in support of fisher's model it ...1985268310
huse, henley, and fisher respond. 198510032275
antisperm antibodies and in vitro fertilization failure.a new enzyme-linked immunosorbent assay (elisa)-based test (zer, jerusalem) has allowed us to show the presence of antisperm antibodies (1:32 to 1:64) in the blood of 14 (33%) of 32 patients undergoing in vitro fertilization and embryo transfer (ivf-et) under gonadotropin stimulation. observation of the morphology of fertilization in eight patients with and seven patients without antisperm antibodies has shown a significant association (p less than or equal to 0.025, fisher exact probability tes ...19854093706
effect of postoperative radiotherapy on the development of small bowel obstruction in patients undergoing staging laparotomy for hodgkin's disease.two hundred and ten previously untreated patients with hodgkin's disease underwent staging laparotomy at one institution. medical records of these patients were retrospectively reviewed. the incidence of small bowel obstruction (sbo); whether or not the patient received abdominal radiotherapy and the portals used; whether or not the patient had undergone a previous operation for unrelated disease; and the outcome of operative treatment for the sbo were noted. mean follow-up for all patients was ...19854083264
fisher renormalization at the smectic-a1 to smectic-a2 transition in a mixture. 198510032085
the herbert differential pitch bone screw in displaced radial head fractures.the herbert bone screw (herbert and fisher, 1984) has been used in the treatment of ten segmental fractures of the radial head. this differential pitch bone screw provides rigid fixation with compression, has no protruding head, is easily introduced and is of such a small diameter that more than one screw can be used. the early results achieved are reported.19854086103
[eeg mapping during a visuo-spatial task. averaged maps and group statistics].twenty young volunteers (10 men, 10 women), righthanded, students, have been recorded in eeg cartography in different situations. we have compared the quantified eegs when the subjects were resting, eyes closed and later, eyes opened, looking at a cartoon. the eegs were quantified by spectral fourier analysis and submitted to data reduction. ten spectral parameters were computed, yielding 51 variables allowing computations and drawings of 90 eeg maps. mean parameters, mean variables, averaged ee ...19854070726
electrophysiologic and antiarrhythmic effects of sotalol in patients with life-threatening ventricular tachyarrhythmias.sotalol is a unique beta-blocker that lengthens cardiac repolarization and effective refractory period (erp). its efficacy after intravenous (1.5 mg/kg) and oral (160 to 480 mg bid) administration was therefore evaluated in 37 patients with refractory recurrent ventricular tachycardia/fibrillation (vt/vf). thirty-five patients, 33 with inducible vt/vf, underwent electrophysiologic testing. intravenous sotalol lengthened the erp in the atrium (+24.6%, p less than .01), atrioventricular node (+24. ...19854017207
planning a cohort or case-control study with allowance for cost and test power.this paper deals with balanced and unbalanced allocation designs in cohort and case-control studies. it focuses on: determination of the equal sample size design given the relative risk, r, of disease, the incidence of disease among the nonexposed group or the prevalence of exposure to risk factor, p1, type i and ii errors alpha, beta; estimation of the unequal allocation designs that either maximize the test power subject to fixed total cost or minimize the total study expenditure subject to pr ...19853850016
[schizophrenically disordered time perception and its modification by neuroleptics].the authors deal with the question as to whether the target symptom "disturbed time perception" is to be considered a basic schizophrenic symptom and whether therapeutical (neuroleptic) control possibilities exist. 135 schizophreniacs have given statistical evidence (intensity quotient, wilcoxon comparison, hotelling-pabst test, exact probability test according to fisher/yates) that the disturbed time perception of schizophreniacs is accessible by a differentiated neuroleptic therapy but is not ...19854048304
thyroid adenoma and ovarian luteinization in an aged fisher (martes pennanti). 19854032637
miller-fisher syndrome (guillain-barré syndrome with ophthalmoplegia) during treatment with gold salts in a patient with rheumatoid arthritis. 19853925959
distinctive-feature analyses of the speech of deaf children.22 children aged 8.5 through 15.5 yrs with htls greater than or equal to 90 db in the better ear spoke a carrier phrase before each of 41 monosyllables containing each an initial and a final consonant (23 consonants were represented). each s repeated the 41-word list 10 times. speech samples were recorded simultaneously but independently in audio-only and in audio-visual modes, and transcribed by 3 judges using each mode separately. percent correct speaker-subjects' utterances of target consonan ...19853842843
barma and fisher respond. 198510031349
method for estimating right ventricular volume by planes applicable to cross-sectional echocardiography: correlation with angiographic formulas.right ventricular (rv) volumes determined by echocardiography were compared with those measured using established angiographic formulas. rv cast displacement volumes were first correlated with data derived from radiographic images of the casts corresponding to standard angiographic rv views. four established angiographic formulas (ferlinz, boak, fisher and thilenius) correlated well with cast volume, with the corrected prism method of fisher showing a best fit (r = 0.98, y = 1.1 + 0.9 x, standar ...19854003302
hypersecretion of gastric acid in a representative finnish family evaluate the family behaviour of acid secretion and particularly of 'hypersecretion', we have examined by pentagastrin test and direct vision gastric biopsy 342 subjects with a normal mucosa or superficial gastritis of the body mucosa, collected from a large family sample of the finnish population. acid output (ao) was expressed in terms of fat-free body weight (ffb), which eliminates the sex factor found by other expressions of ao. subjects with values above 1.0 mmol/h/ffb were considered 'h ...19854023613
some goodness-of-fit methods for the poisson plus added zeros distribution.methods for making inferences about the poisson plus added zeros distribution and the truncated poisson distribution are presented and illustrated with bacteriological data. some of the methods are designed for testing the compatibility of the zero frequency with the poisson distribution, whereas others are given for testing the goodness of fit for the truncated poisson. in particular, a modified form of the fisher index of dispersion is presented which is suitable for the truncated case. it is ...19854004245
privman-fisher hypothesis on finite systems: verification in the case of the spherical model of ferromagnetism. 19859936381
correction of abnormal renal blood flow response to angiotensin ii by converting enzyme inhibition in essential 40-50% of patients with essential hypertension, a high sodium intake does not increase renal blood flow (rbf). these patients have been defined as nonmodulators because sodium intake does not modulate renal and adrenal responsiveness to angiotensin ii (aii). to define the role of aii in mediating this altered responsiveness, we assessed the effect of a converting enzyme inhibitor (enalapril) on rbf and its responsiveness to aii in 25 patients with essential hypertension--10 modulators and 15 ...19852985655
relapsing ophthalmoparesis-sensory neuropathy syndrome.we studied two patients with recurrent sensory neuropathy and weakness of extraocular muscles. there was electrophysiologic evidence of multifocal demyelination of sensory nerves, with relative sparing of somatic motor nerves. sural nerve biopsy in one patient showed segmental demyelination. we believe that these patients had an unusual form of inflammatory polyneuropathy--possibly a relapsing variant of the miller-fisher syndrome of acute idiopathic polyneuritis.19852984602
privman-fisher hypothesis on finite systems: verification in the case of a relativistic bose gas with pair production. 19859895689
biochemical and clinical evaluation of a new cellulose diacetate secondary filter for cascade filtration.we have performed 24 cascade filtration treatments in 8 patients with hyperviscosity syndrome (2 cases), essential mixed cryoglobulinemia, post-hepatitic cryoglobulinemia, sjogrens disease, rheumatoid vasculitis, miller-fisher syndrome and chronic dysimmune polyneuropathy. new cellulose diacetate filters were employed, giving a satisfactory performance. at 1.5 l plasma treatment, the rejection rate for macromolecular plasma components was close to 90%, whereas albumin recovery was close to 70%. ...19853921467
cerebral atrophy in patients on long-term regular hemodialysis treatment.the presence of cerebral atrophy in the form of cortical damage (cortical atrophy) or subcortical damage (enlargement of ventricular cavities) was explored by computed tomography (ct) scans in 30 patients maintained on regular hemodialysis treatment (rdt) for not less than 10 years, and less than 50 years of age. whereas a group of 50 normal subjects of the same age, used as control, gave no evidence of cerebral atrophy, 46.6% of the patients maintained on rdt showed cortical atrophy, evenly dif ...19853872759
precursor prothrombin status in patients receiving anticonvulsant drugs.protein induced by vitamin k absence (pivka) is the circulating prothrombin precursor found in considerable concentrations when carboxylation of prothrombin is impaired. in this study pivka-positivity was assessed in adult epileptic patients receiving a variety of anticonvulsant drugs. mean pivka (+/- sd) concentration was 4.6 +/- 2.3% in 16 epileptics vs 1.1 +/- 0.7% in 10 age-matched controls (p less than 0.001). 13 of the 16 (81%) epileptics had pivka values above the highest value recorded f ...19852857211
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