PMID(sorted ascending)
a sexual dimorphism of mucous cells in the submandibular salivary gland of rat.submandibular glands of both sexes from one week to six months-old were serially sectioned, and mucous cells showing a strong positive stain to alcian blue ph 2.5, first detected at two weeks, showed a high degree of inter-sectional and inter-individual variability. in males, the percentage of animals having mucous cells increased with sexual maturation and attained 100 per cent at age six months. in females, the maximum (60 per cent) was reached by four weeks and then decreased with sexual matu ...19872451903
generation of thyroglobulin-specific t-cell clones derived from f1 fisher rats.we established t-cell clones from 'poor-responder' fisher rats specific for thyroglobulin (tg) with a view to examining tg presentation by cloned fisher rat thyroid (frtl) cells. from the screening of 60 t-cell clones, three high-responding tg-specific clones (b21.01, b21.04 and b21.05) were isolated from the lymph nodes of f1 generation (fisher x 'high-responder' buffalo) female rats immunized with murine tg in complete freund's adjuvant (cfa). three t-cell clones expressed a w3/25+, ox-8- phen ...19882454882
use of alpha-1-antitrypsin staining in the diagnosis of nodular regenerative hyperplasia of the liver.nodular regenerative hyperplasia (nrh) is a disorder characterized by regenerative nodules scattered diffusely throughout the liver without associated fibrosis. it is most often recognized at autopsy when the entire liver is available for inspection. the diagnosis of nrh by needle biopsy is much more subtle. since alpha-1-antitrypsin (aat) expression by hepatocytes in a variety of liver diseases has suggested that it may represent a marker for regenerative or damaged hepatocytes, we elected to s ...19882458312
the measurement of cisplatin-dna adduct levels in testicular cancer patients.seventeen patients with 'poor prognosis' non-seminomatous testicular cancer were monitored for formation of intrastrand bidentate n7-d(apg)- and n7-d(gpg)-diammineplatinum adducts in peripheral blood cell dna during the course of cisplatin-based chemotherapy. adduct values from blood cell dna samples were compared with disease response data from the same individuals. patients who received a dose of 40 mg/m2 cisplatin for 5 days generally formed more adducts than patients receiving 20 mg/m2 for 5 ...19882458857
[structure of the o-specific polysaccharides and the protective activity of the lipopolysaccharides in pseudomonas aeruginosa of 7 immunotypes (after fisher)].the structure of o-specific polysaccharides and the protective activity of lipopolysaccharides (lps) obtained from seven p. aeruginosa immunotypes (according to fisher's classification) have been studied. the structure of o-specific polysaccharides, immunotypes 2, 3, 4, 5 and 6, is identical to that of polysaccharides of serotypes 011; 0(2a), 2c; 01; 010a, 10b; 07a, 7d respectively. no structural analogs of o-polysaccharide characteristic of immunotypes 1 and 7 have been detected among serotypes ...19882459868
seroma prevention using fibrin glue during modified radical neck dissection in a rat model.seroma is a frequent sequelae of neck dissection involving cervical lymphadenectomy. the incidence is correlated with flap elevation, lymphovascular interruption, and tissue removal. current methods of resolving seroma, such as vacuum drainage, are not risk free. a novel approach to this problem was the use of intraoperative topical fibrin glue. a model producing seromas was developed by modified radical neck dissection on sprague-dawley rats. forty rats underwent this procedure. twenty rats wer ...19882459980
the mechanism of tachykinin-induced bronchoconstriction in the rat.the mammalian tachykinins substance p (sp) and neurokinin a (nka) are known to be present in sensory airway nerves of animals and humans. we studied the effect of mammalian and nonmammalian tachykinins on the conducting airways of anesthetized, mechanically ventilated fisher 344 rats. dose-dependent increases in lung resistance and decreases in dynamic compliance occurred after the intravenous administration of eledoisin (e), kassinin (k), nka, and sp. e, k, and nka were more potent bronchoconst ...19882461668
enhanced induction of thyroid cell mhc class ii antigen expression in rats highly responsive to thyroglobulin.initial experiments demonstrated that the degree of autoantibody and proliferative t cell responses to syngeneic rat thyroglobulin differed markedly between buffalo (high responder) and fisher (low responder) rats after classical immunization schedules. while varying immune responsiveness may be due to qualitative and quantitative t and b cell differences, the role of thyroid cell mhc class ii antigens may be pivotal to the onset of autoimmune thyroiditis in such animal models. we, therefore, ex ...19892466637
lithium increases rat striatal beta- and gamma-preprotachykinin messenger rnas.previous reports indicate that the antimanic drug, lithium, increases substance p-like immunoreactivity (sp-li) in the basal ganglia. the aim of this study was to use lithium as a pharmacological tool to further understand the mechanism of this process. we have used solution hybridization-nuclease protection assays to quantitate the specific preprotachykinin (ppt) mrnas and radioimmunoassays and immunocytochemistry to assess sp-li levels in the striatum of male fisher f-344 rats. a regimen of su ...19892467980
[a study on accumulation of cholesterol in rat prostate].an experimental model of prostatic hypertrophy was created by freezing the urethra at the opening of the ventral prostate in rats and administering a cholesterol-rich diet to induce cholesterol accumulation. four-week-old fisher rats were divided into a control group, a cholesterol-rich diet group (by adding 1% cholesterol to the diet), a frozen group, and a frozen and cholesterol-rich diet group, and were reared for 5 months. the animals were killed, and the ventral prostate was removed, weighe ...19892472053
[anthrax toxin dynamics in the body].anthrax toxin introduced subcutaneously into white rats fisher-344 caused specific intoxication accompanied by characteristic pathomorphological changes and, when studied by the immunoperoxidase method in histological sections, could be detected in the blood stream (in plasma) and in the cytoplasm of macrophages (in the lungs and the spleen). the content of the preparation introduced into the animals in the blood stream is directly related to its toxicity, being probably indicative of the relati ...19892472713
penetrating keratoplasty in the rat: a model for the study of immunosuppressive treatment of graft rejection.the present study reports corneal allogeneic transplantation in a rat model. the technique used was full-thickness penetrating keratoplasty. fisher rats were used as donors and lewis rats were used as recipients. the rate of acute rejection obtained in this model with this combination of strains was 100%. it therefore seems to be a very useful model for the study of rejection and for the study of new immunosuppressive treatment. the effect of systemic cyclosporine (csa) treatment on graft reject ...19892474684
indications for cisternal drainage in conjunction with early surgery in ruptured aneurysms and timing of its discontinuation.the efficacy of cisternal drainage in association with early aneurysmal surgery remains highly controversial. the authors attempted to clarify the indications for this procedure and the proper timing of drainage removal in a series of 205 patients with no evidence of intracerebral hematoma who underwent surgical obliteration of bleeding aneurysms within 72 hours after subarachnoid hemorrhage. the 136 patients in whom cisternal drainage was performed constituted group a and the remaining 69 patie ...19892477741
traveling waves of in vitro evolving rna.populations of short self-replicating rna variants have been confined to one side of a reaction-diffusion traveling wave front propagating along thin capillary tubes containing the q beta viral enzyme. the propagation speed is accurately measurable with a magnitude of about 1 micron/sec, and the wave persists for hundreds of generations (of duration less than 1 min). evolution of rna occurs in the wavefront, as established by front velocity changes and gel electrophoresis of samples drawn from a ...19892479013
a cell mutant that exhibits temperature-dependent sensitivity to transformation by various oncogenes.we previously isolated a fisher rat fibroblast mutant, b812, that has the unique property of temperature-dependent transformation by various oncogenic retroviruses. at the permissive temperature (35 degrees c), this mutant was sensitive to oncogenic transformation and formed foci on a dish at the same frequency as did the parental fibroblast cell line. when kirsten murine sarcoma virus (ki-msv) was applied to the cells, the frequency of focus formation decreased more than 25-fold at the nonpermi ...19892479832
nicotinamide enhances skin flap survival.the effects of nicotinamide in an abdominal island pedicle skin flap were examined. a 7 x 7 cm island pedicle skin flap ligating the left inferior neurovascular pedicle was created on 50 male sprague dawley rats (250-275 grams) that were divided into five groups. animals received either 0.6 cc of saline or doses of nicotinamide for 16 days (14 days preoperatively and 2 days postoperatively): 25 mg b.i.d., 50 mg b.i.d., 100 mg b.i.d. or 200 mg b.i.d. forty-eight hours postoperatively each animal ...19892482537
placenta previa and congenital cardiac anomalies.this study was designed to evaluate the association of placenta previa (pp) with cardiac anomalies in the fetus/neonate. the study group (n = 82 babies) was compared to a control group (n = 82) matched for maternal and gestational age. five babies of the study group expired within 24 h of delivery, and postmortem examination was carried out in 4 of them. the living children of the control and study group (51 of the 77 babies) underwent complete cardiac workup including physical examination, ecg, ...19892486886
[c-reactive protein as early marker of chorioamnionitis in premature rupture of membranes].this study was done in order to correlate the c-reactive protein levels (crp) determined by nephelometric technique, with other infection indicators, and to know its exactness in early detection of chorioamnioitis. thirty patients were prospectively studied with pregnancies from 28 to 35 weeks of gestation with diagnosis of premature rupture of membranes (prm); and were compared to control group (30 patients) with similar gestation without prm, infection, autoimmune diseases or chronic inflammat ...19892486952
use of verbal descriptors, thermal scores and electrical pulp testing as predictors of tooth pain before and after application of benzocaine gels into cavities of teeth with pulpitis.a double-blind pilot study was conducted on 27 consenting human volunteers who had irreversible pulpitis associated with persistent toothache pain from open carious lesions. formulations tested contained either 0, 10%, or 20% benzocaine and were identified only by a numbered code. before the experiment started, a small amount of a known 5% benzocaine gel was placed for 1 minute on the tongue of each patient to assure a sensation of numbness within the oral cavity. then the test tooth was washed ...19892490060
reovirus induction of mhc class ii antigen in rat thyroid cells.we have previously demonstrated that cultured rat thyroid cells do not exhibit constitutive expression of major histocompatibility (mhc) class ii antigens. using reovirus types 1 and 3, we infected 1b-6 cells (a cloned derivative of the fisher rat cell line frtl-5), and found a dose-dependent induction of thyroid cell mhc class ii antigen expression as determined by laser flow cytometry and fitc-labelled ox-6 anti-rt1.b. as the number of viral particles/cell used for the infections increased fro ...19892491810
isolation, structure, and immunogenicity of pseudomonas aeruginosa immunotype 4 high-molecular-weight polysaccharide.a high-molecular-weight, immunogenic form of the lipopolysaccharide o side chain of pseudomonas aeruginosa fisher immunotype 4 (type 4, international antigenic typing system 1, lanyi o:6) was isolated and characterized. analysis by nuclear magnetic resonance spectroscopy confirmed the structural similarity of this high-molecular-weight polysaccharide and the type 4 o side chain. the polysaccharide was immunogenic in rabbits and mice, eliciting opsonophagocytic killing antibodies. immunization wi ...19892492260
heat shock-induced appearance of rna polymerase ii in karyoskeletal protein-enriched (nuclear "matrix") fractions correlates with transcriptional shutdown in drosophila melanogaster.heat shock in vivo or brief incubation at moderately elevated temperatures (15 min at 37 degrees c) in vitro is required for the structural stability of proteinaceous karyoskeletal elements purified from drosophila melanogaster (mcconnell, m., whalen, a. m., smith, d. e., and fisher, p. a. (1987) j. cell biol. 105, 1087-1098). we have found that the appearance of the two largest subunits of rna polymerase ii in karyoskeletal preparations is promoted by conditions identical to those which promote ...19892492538
high specific activity [samarium-153] edta for imaging of experimental tumor models.enriched samarium oxide (98.2% 152sm2o3) was irradiated in low neutron flux and high neutron flux reactors to produce 153sm with specific activities of 14.3 gbq and 22.1 tbq mmol-1 sm, respectively, at the time of use. formulation of 153sm as [153sm]edta, with a 1:10 molar ratio of sm:edta, provided a stable radiotracer in vitro and in vivo. high specific activity [153sm]edta showed superior uptake in cell culture (20.8 +/- 0.9% vs. 5.5 +/- 0.1% for 6 and 600 pmol sm per 10(6) cells, respectivel ...19892500500
a reappraisal of the epidemiology of phenotypes of neisseria gonorrhoeae.we analyzed published data from studies of the epidemiology of gonococcal auxotype/serovar phenotypes in seattle and king county, washington; denver, colorado; and miami and dade county, florida, to determine whether the numbers of new phenotypes were within the ranges of numbers predicted from previous observations in the same populations. for this analysis, we used the model of fisher and good and turing. in all the analyses, the observed number of new species was within the 95% confidence reg ...19892500719
thyrotropin-releasing hormone (trh)-gly conversion to trh in rat ventral prostate is inhibited by castration and aging.trh levels in rat prostate are very high in the 2-month-old rat and decline at least 90% during the next 2 yr. this decline in prostatic trh levels with aging may be a significant factor in benign prostatic hypertrophy in man and other animals. because prostatic trh correlates positively with serum testosterone and negatively with serum thyroid hormone levels, we have examined the possibility that the age-related decline in prostatic trh is hormonally regulated. trh and a trh precursor peptide, ...19892502375
recognition and binding of template-primers containing defined abasic sites by drosophila dna polymerase alpha holoenzyme.human dna polymerase alpha holoenzyme follows an ordered sequential terreactant mechanism of substrate recognition and binding (wong, s. w., paborsky, l. r., fisher, p. a., wang, t. s.-f., and korn, d. (1986) j. biol. chem. 261, 7958-7968). we confirmed this mechanism for the dna polymerase alpha holoenzyme purified from drosophila melanogaster embryos and studied the interaction of drosophila pol alpha with synthetic oligonucleotide template-primers containing modified tetrahydrofuran moieties ...19892502545
the structure and serologic distribution of an extracellular neutral polysaccharide from pseudomonas aeruginosa immunotype 3.previous work has described small molecular weight neutral polysaccharides from isolates of pseudomonas aeruginosa that appear to be associated with the lipopolysaccharide (lps) and distributed across serologic barriers defined by antibody to the o side chain. we have isolated and characterized another of these structures obtained from culture supernatants of an immunotype 3 strain of p. aeruginosa. the isolated neutral polysaccharide has a tetrasaccharide repeat unit: (formula; see text) where ...19892504722
difference in catalepsy response in inbred rats during chronic haloperidol treatment is not predictive of the intensity of behavioral hypersensitivity which subsequently animal model was utilized to explore the observed clinical association between a history of significant neuroleptic-induced parkinsonism and an increased incidence for the subsequent development of tardive dyskinesia. catalepsy-sensitive fisher rats and catalepsy-resistant brown norway rats were treated for 14 days with haloperidol at a dose of either 1 mg/kg or 5 mg/kg daily. following a 7-day drug withdrawal period, rats were tested for behavioral hypersensitivity to acute challenge with ap ...19892505286
large virchow-robin spaces: mr-clinical correlation.high-field mr scans frequently show virchow-robin spaces, which conform to the path of the penetrating arteries as they enter either the basal ganglia or the cortical gray matter over the high convexities. a retrospective review of 816 mr scans was undertaken to determine the clinical significance and associations (if any) of this finding. the virchow-robin spaces were graded, as were the nonspecific white-matter lesions. the presence of atrophy, infarction, hydrocephalus, and miscellaneous dise ...20082505536
blockade of conditioned avoidance responding by trazodone, etoperidone, and mcpp.phenylpiperazines, such as meta-chlorophenylpiperazine (mcpp) a serotonin agonist, have recently been reported to block conditioned avoidance responding (car) in the rat, which is an indication of possible antipsychotic utility. since mcpp is a major metabolite of both antidepressant drugs trazodone (tz) and etoperidone (et), both were examined for activity in blocking car in a single-trial lever press task in fisher 344 rats. both tz and et produced dose-related falls in car with ed50 values (9 ...19892506609
growth hormone (gh) secretion in the pituitary-grafted male rat: in vivo effects of gh-releasing hormone and isoproterenol and in vitro release by individual somatotropes.although the pituitary-grafted rat is a classic model of chronic prl excess, the presence of somatotropes in grafted pituitary tissue indicates a potential for gh secretion. the current study was designed to investigate gh-releasing hormone (grh)-induced gh secretion and beta-adrenergic inhibition of gh release in animals bearing ectopic pituitary tissue free from hypothalamic control. positive findings with regard to these in vivo experiments led us to an initial determination of gh secretion b ...19892507290
lectin typing of pseudomonas aeruginosa strains of different serogroups, habs and fisher types.sixteen habs and three fisher types of pseudomonas aeruginosa were typed with lectins of know specificity resulting from their interaction with bacterial cell surface carbohydrates as evidenced by agglutination-inhibition assay with simple carbohydrates. lipopolysaccharides of few strains of pseudomonas are precipitated with different lectins and the results are corroborated by those of agglutination suggesting that pseudomonas aeruginosa can be characterized intraspecifically by lectins.19892508658
isolation and characterization of a human monoclonal antibody that recognizes epitopes shared by pseudomonas aeruginosa immunotype 1, 3, 4, and 6 lipopolysaccharides.a hybridoma line secreting a human monoclonal antibody (hmab) capable of recognizing fisher immunotype (it) 1, 3, 4, and 6 lipopolysaccharide (lps) in vitro was isolated. peripheral blood lymphocytes (pbl) were obtained from volunteers immunized with an experimental pseudomonas aeruginosa o polysaccharide-toxin a vaccine. pbl-expressing surface antibodies able to bind to p. aeruginosa lps were isolated by adsorption onto lps-coated plastic wells. such pbl were transformed with epstein-barr virus ...19892509371
sarcocystis sp. in mountain goats (oreamnos americanus) in washington: prevalence and search for the definitive host.during october and november 1986, sarcocystis sp. was detected in 24 of 56 (43%) tongues from hunter-killed mountain goats (oreamnos americanus) in washington (usa). sarcocysts had an unusual sessile polyp-shaped branched wall. mean size of 154 sarcocysts was 71.3 x 37.8 microns (range, 20 to 248 x 10 to 120 microns), and the mean intensity was 2.3 (range, 1 to 28). in an attempt to identify the definitive host, infected tongues were fed to four coyotes (canis latrans), eight domestic dogs, four ...19892509738
inhibition of implantation of murine bladder tumor by thiotepa in cauterized bladder.this study was designed to determine the role of immediate intravesical instillation of single dose thiotepa post transurethral resection of bladder tumor in the prevention of recurrence by tumor implantation, using murine bladder tumor line 2 and 201 c3h/he mice. previous studies have suggested implantation may take place as early as the first hour and reach its maximum in 24 hours after resection of bladder tumor. an in vitro dose response curve of mbt2 to thiotepa was established by treatment ...19892511340
[specific intoxication in anthrax infection].the pathomorphological picture of experimental b. anthracis infection in white rats (strain fisher-344) essentially corresponds to experimental anthracic intoxication with very moderately pronounced morphological manifestation of b. anthracis invasion. this indicates that specific anthracic intoxication is an essential component of the pathological process in b. anthracis infection.19892511710
effects of diethylstilboestrol on testicular function and luteinizing hormone male fisher-344 rats were implanted with des-filled or empty silastic capsules. after 14 weeks, capsules were removed and a second group of rats received des capsules. seven weeks later, all the rats were sacrificed. des treatment decreased body, testes and seminal vesicle weights, and removal of the capsules partially restored the weight of these organs. the concentration of testicular lh receptors was increased by des treatment. circulating prl levels were increased and gonadotropin leve ...19892515561
[2 methods for the study of differential mortality based on sex: rates ratio and orthogonal regression].sex mortality differential is studied for all the causes of death, in la coruña (galicia, spain), according to geographic area, zone (urban, semiurban and countryside) and decade (1961-1970 y 1971-1980). two study methods are compared: a) rate ratio (with direct age-adjusted rates); and b): differential (dj) between observed rate (m) and expected rate (m), for male mortality, according to female level (orthogonal regression model). t-student-fisher tests have been used to compare an observed mea ...20162517786
[results of cross-species transplantation of substantia nigra to the lateral ventricle of the brain of rats with experimentally-induced parkinson disease].the method of compensation of dopamine (da) deficit in the striatum by living, da producing cells implanted into the brain, creates new hopes for patients with parkinson's disease. in view of many ethical and legal problems, connected in some countries with obtaining human fetal tissue for transplantation, cross-species transplants would be an attractive alternative. the subject of our investigation was the problem of survival and functioning of embryonal substantia nigra (sn) neurons, taken fro ...19892518574
intravenous nicardipine for treatment of intraoperative hypertension during abdominal surgery.twenty patients, american society of anesthesiologists class i or ii, who developed intraoperative hypertension (mean arterial pressure greater than 110 mm hg) during abdominal surgery under balanced general anesthesia were randomly assigned to two groups. the nicardipine group (n = 10) received 5 mg of nicardipine hydrochloride, and the placebo group (n = 10) received 5 ml of nicardipine solvent injected intravenously over a 5-minute period in a blind manner. arterial pressure was recorded for ...19892521027
the calmodulin binding domain of the plasma membrane ca2+ pump interacts both with calmodulin and with another part of the pump.synthetic peptides corresponding to the calmodulin-binding domain of the human erythrocyte ca2+ pump were prepared representing residues 2-29 (c28w), 2-21 (c20w), 2-16 (c15w), and 16-29 (c14) of the sequence (james, p., maeda, m., fisher, r., verma, a. k., krebs, j., penniston, j. t., and carafoli, e. (1988) j. biol. chem. 263, 2905-2910). peptides c28w, c20w, and c15w bound to calmodulin with an apparent 1:1 stoichiometry in the presence of ca2+ and inhibited the activation of the ca2+ pump by ...19892526124
interleukins production and responsiveness in fisher rats with adjuvant-induced disease: role of suppressor cells.splenic macrophages from aid fisher rats produce normal levels of il-1, in contrast to il-2 which is significantly lower than normal. a state of hyporesponsiveness of spleen cells to con-a and pha occurs with similar kinetics to and is correlated with the development of an articular arthritis; il-1 addition to aid spleen cell cultures does restore to normal their deficient response, in contrast to addition of il-2 or ril-2. the spleen cells from normal or aid rats are equally sensitive to the in ...19892526223
complementation of enteric adenovirus type 40 for lytic growth in tissue culture by e1b 55k function of adenovirus types 5 and 12.the enteric adenovirus type 40 strain dugan (ad40) cannot be passaged in hela cells, but will grow in 293 cells, which express ad5 e1 functions. to determine the reason for this limited host range, kb cell lines expressing ad2 e1a, e1b, or e1a + e1b (l. e. babiss, c. s. h. young, p. b. fisher, and h. s. ginsberg, 1983, j. virol. 46, 454-465) have been tested for their ability to support ad40 replication. only cell lines which supply e1b functions, but not those expressing e1a alone, are permissi ...19892527440
functional analysis of lymphocytes subpopulations in experimental cocaine abuse. i. dose-dependent activation of lymphocyte subsets.the potential role of substance abuse, especially cocaine and alcohol as co-factor in hiv infection and in the development and expression of aids has been suggested, but the possible biological role of substance abuse in the development of aids is not known. in order to better understand immune system function in chronic cocaine abuse, we have assessed primary b cell responses to helper t-cell independent (ti) and dependent (td) antigens in inbred fisher male rats injected with 1.25-5 mg cocaine ...19892528433
effect of cyproterone acetate in comparison to flutamide on the ventral prostate of adult male castrated copenhagen-fisher rats and on dunning r-3327 h this investigation the effect of cpa was tested in comparison to fl after the procedure of double blinding on the ventral prostate of 70 adult male castrated copenhagen-fisher rats and on the dunning r-3327 h tumor. total androgen blockade by castration plus cpa or by castration plus fl induced significant decrease in prostate weight compared to the androgen deprivation by castration alone. no significant difference between cpa and fl was observed. furthermore it was impossible to exaggerate ...19892530921
[relationship between heart mass and semi-ambulatory pressure profiles].this work was undertaken with 420 patients (90 normotensives: casual blood pressure less than or equal to 140/90 mmhg and 330 hypertensives) in which was recorded a semi ambulatory blood pressure profile (dinamap 8am-8pm, a reading every fifteen minutes). on the same day an echocardiogram was performed. we have correlated the left ventricular mass, the left ventricular mass index, the interventricular septum, the left ventricular cavity volume and the left ventricular posterior wall with casual ...19892530949
normal brain tissue response to photodynamic therapy: histology, vascular permeability and specific gravity.the response of photodynamic therapy on normal brain was investigated in 140 fisher rats. the rats were injected i.p. with photofrin ii (12.5 mg/kg) and 48 h later the dural area over the frontal cortex was photoactivated with red light (630 +/- 1 nm) from an argon dye laser. treatment was performed with optical energy densities of 140 and 70 j/cm2. histopathology, vascular permeability and specific gravity measurements were conducted on different populations of rats at 4 h, 24 h, 72 h and 1 wee ...19892533693
immunological functions in food-restricted rats: enhanced expression of high-affinity interleukin-2 receptors on splenic t cells.several immunological functions of b and t cells including il-2 receptor expression on t cells were measured in 12-month-old fisher-344 male rats maintained from 6 weeks of age on an ad libitum (al) or a 40% food-restricted (fr) diet. direct anti-srbc plaque-forming cell (pfc) assays revealed a higher response in fr rats than in al rats when splenocytes were cultured with or without recombinant interleukin-2 (ril-2). b cell functions were studied by using nylon wool-purified splenic b cells stim ...19892534390
results of conservative surgery and radiation therapy for multiple synchronous cancers of one breast.a small number of patients with early stage breast cancer are found on presentation to have two or more separate carcinomas within the breast. to assess the effectiveness of conservative surgery and radiation therapy in these patients we compared treatment outcome among 10 patients with multiple lesions (21 cancers) and 707 patients with single lesions, treated at the joint center for radiation therapy between 1968-1981. median follow-up was 64 months and 75 months for the multiple and single le ...19892536361
triethyllead-induced peroxidative damage in various regions of the rat male fisher 344 rats (8-10 wk old) were dosed ip with 1.75 mg/kg body weight of triethyllead chloride (tel) for 5 consecutive days. rats were sacrificed 1, 7, or 21 d after the last injection. the rate of lipid peroxidation was significantly elevated in frontal cortex at all three time points assayed (1, 7, or 21 d). however, hippocampal and cerebellar membranes showed no changes in peroxidative capacity at these time points. in order to determine whether cortical membrane damage was refle ...19892537905
vip receptors and content after bowel transplantation.advances in immunosuppressive therapy have renewed interest in small bowel transplantation. little is known, however, about the functional capacity of transplanted intestine. to clarify the potential for normal function, we investigated whether elements of the enteric nervous system are preserved after denervation in our rat model of intestinal transplantation. we investigated whether vip, a major peptide neurotransmitter of the enteric nervous system, and its receptors are preserved in the bowe ...19892541280
diagnostic usefulness of mycobacterial skin test antigens in childhood lymphadenitis.nontuberculous mycobacterial (ntm) infections are a frequent cause of chronic lymphadenitis in children. previous studies of ntm antigen skin testing were inconclusive as a result of problems with study design and antigen formulation. the present study was undertaken with the centers for disease control to determine whether newly formulated ntm skin test antigens applied in a double blind manner with a standard purified protein derivative could accurately distinguish ntm infections from those ca ...19892541397
endogenous digoxin-like immunoreactive factor and digitalis-like factor associated with the hypertension of patients receiving multiple alkylating agents as part of autologous bone marrow transplantation.1. hypertension is a complication of autologous bone marrow transplantation when therapy includes multiple alkylating agents. we have sought to identify the factors underlying this hypertension. we measured weight, serum creatinine, plasma renin activity, aldosterone and digoxin-like immunoreactive factor (dlif), by digoxin radioimmunoassay, in 18 patients. plasma catecholamines were also measured in five patients. 2. of the 18 patients studied, 15 became hypertensive. the variable most consiste ...19892555106
fbl-reactive cd8+ cytotoxic and cd4+ helper t lymphocytes recognize distinct friend murine leukemia virus-encoded antigens.immunization of c57bl/6 (b6) mice with fbl, a friend murine leukemia virus (f-mulv), induces both tumor-specific cytolytic cd8+ (ctl) and lymphokine-producing cd4+ th that are effective in adoptive therapy of b6 mice bearing disseminated fbl leukemia. the current study evaluated the f-mulv antigenic determinants expressed on fbl that are recognized by fbl-reactive cd8+ and cd4+ t cells. to identify the specificity of the fbl-reactive cd8+ ctl, fisher rat embryo fibroblast (fre) cells transfected ...19892562982
[ergonomic analysis of the work sites and living conditions of the crew on board the b-418/111 t/h "bonito" ppd and ur "gryf" fishing trawlers].the paper is an ergonomic study of the sanitary and living conditions at the working place of fishers on long-distance fishing vessels, such as the trawler b-418/111 t/h "bonito". the research was performed during the trip in the region of the falkland islands (malvinas). prophylactic examinations were carried out during 162 days on 77 members of the crew and the hygienic-sanitary conditions on the vessel were analysed. the ergonomic research included all the working places of the members of the ...19892571193
how often are polymorphic restriction sites due to a single mutation?an approximate expression is obtained for the probability that a restriction site, which is polymorphic in a random sample, is a site at which two or more mutations have occurred in the descent to the sample from the most recent common ancestor of the sample. the analysis is based on the assumption that the population from which the sample is obtained is at equilibrium under a selectively neutral wright-fisher model. monte carlo simulations show that the approximation is quite accurate. for comm ...19892572069
activation of a ribosomal s6 protein kinase in rapidly emerging diethylnitrosamine-induced gamma-glutamyltranspeptidase-positive hyperplastic liver lesions of the rat.the gamma-glutamyl transpeptidase (ggt)-positive hyperplastic liver lesions which developed in the fisher 344 rat 7 and 60 days following a single carcinogenic dose of diethylnitrosamine (dena, 200 mg/kg body weight), short-term dietary exposure to 0.02% 2-acetylaminofluorene (aaf) to suppress the growth of normal hepatocytes, and partial hepatectomy to actuate rapid growth of dena altered hepatocytes not suppressed by aff, showed an increased activity of a kinase which specifically phosphorylat ...19892575815
distribution of the c-myc oncoprotein in normal and neoplastic tissues of the rat colon.a rat model of 5-azoxymethane induced colon cancer was studied in order to correlate histopathological changes and the differential distribution of the c-myc protein. weanling fisher 344 rats were injected with three, one week apart, subcutaneous injections of 5-azoxymethane (aom) (15 mg kg-1) and the animals were divided into low and high fat diet groups. nine colon tumors, of varying degrees of malignancy, that developed in the aom-treated rats, and sections of normal colonic mucosa were exami ...19882577872
pausing of rna polymerase during in vitro transcription through the ilvb and ilvgeda attenuator regions of escherichia coli k12.synchronized single-round transcriptions, in vitro, from templates encoding the leader rna of the ilvb and ilvgeda operons result in the accumulation of a transcript consistent with rna polymerase pausing after the 1:2 stem that could form in each of the leader rnas. addition of l-factor or guanosine 5'-diphosphate,3-diphosphate extended the pause half-life obtained with the ilvb template; addition of l-factor and guanosine 5'-diphosphate,3'-diphosphate together had an additive effect on the pau ...19852578464
a model of the peritoneal cavity for use in internal dosimetry.several therapeutic and diagnostic techniques involve injection of radioactive material into the peritoneal cavity. estimation of the radiation dose to the surface of the peritoneum or to surrounding organs is hampered by the lack of a suitable source region in the phantom commonly used for such calculations. we have modified the fisher-snyder phantom to include a region representing the peritoneal cavity which may be employed to estimate such radiation doses. a geometric model is described whic ...19892585102
variables predicting surgical outcome in symptomatic hydrocephalus in the elderly.we prospectively studied 30 older patients who had shunt surgery for symptomatic hydrocephalus and measured outcome using serial videotaping of gait, neuropsychological testing, and the katz index of activities of daily living. twenty-three patients improved and 7 did not. using univariate analysis and the fisher exact test, we found that the following variables were significantly related to outcome: (1) time b-waves present on 24-hour csf pressure record; (2) anterior/posterior ratio on slice 4 ...19892586777
some simple methods for linkage analysis.a method of analysis of suitable many-locus linkage data used by fisher in 1922 is re-examined in detail, and it is pointed out that it could be used also in human genetics as a simple method for preliminary examination of data.19892596834
alteration of tissue magnesium levels in rats by dietary vitamin b6 supplementation.tissues from female fisher rats fed varying levels of magnesium (100 ppm or 700 ppm) and pyridoxine hydrochloride (pn.hcl) (7, 35, or 1500 mg/kg diet for six weeks) were dry ashed and analyzed for magnesium using atomic absorption spectroscopy. in tissues from rats consuming magnesium diets, tissue magnesium levels increased as levels of dietary pn.hcl increased. increases in plasma, liver, kidney, and brain magnesium levels were statistically significant (p less than 0.05). with the exception o ...19892599796
cholesterol esterification plays a major role in determining low-density-lipoprotein receptor activity in primary monolayer cultures of rat hepatocytes.1. we have previously shown that the capacity for specific binding of human 125i-labelled low-density lipoprotein (ldl) to rat hepatocytes increases with time in culture [salter, bugaut, saxton, fisher & brindley (1987) biochem. j. 247, 79-84]. 2. in the present study we show that this up-regulation is accompanied by a rise in the cholesterol ester content of the cells. 3. inhibition of cholesterol esterification with the drug 58-035 (sandoz) significantly decreases the time-dependent 'up-regula ...19892604696
inter- and intraobserver variability in the histopathological diagnosis of medullary carcinoma of the breast, and its prognostic hundred thirty-one breast carcinomas with medullary features, registered in the danish breast cancer cooperative group from 1977-1982, have been histopathologically reviewed by two senior pathologists and classified as typical medullary carcinoma (tmc), atypical medullary carcinoma (amc), and non-medullary carcinoma (nmc). diagnostic criteria were based on those put forward by ridolfi et al. and fisher et al. the procedure was repeated with an interval of about one year by both pathologists. ...19892605345
segregation analysis of quantitative traits in nuclear families: comparison of three program packages.segregation analysis frequently is used to test for the presence of major gene effects and to estimate the various genetic and environmental components contributing to diseases. recent advances in both theoretical models and computational algorithms have provided a number of new programs for performing segregation analyses. we compared two newer programs: regc (part of the package "sage") and fisher/mendel with an older established program (pap) to determine relative accuracy in recovering param ...19892606342
changes of blood flow in the adenohypophysis of normal and estrogen pretreated fisher rats by tamoxifen.blood flow was measured in the adenohypophysis and in the cerebral cortex of female f344 rats over a period of 90 min using the hydrogen clearance method. tamoxifen, 1 mg/kg, administered iv reduced the blood flow in the adenohypophysis by 35%, whereas cerebral blood flow and arterial pressure remained unchanged. seven days sc treatment with tamoxifen (1 mg/kg daily) had no demonstrable effect on blood flow. anterior pituitary hyperplasia was induced in 15 rats with diethylstilbestrol containing ...19892609903
[miller-fisher syndrome. presence of high signal foci in the cerebral white substance visible with magnetic resonance imaging]. 19892610457
comparative cariogenicity and dental plaque-forming ability in gnotobiotic rats of four species of mutans streptococci.the four species, each represented by two strains, all produced high levels of fissure caries in the upper and lower jaws of gnotobiotic fisher rats. streptococcus rattus strains and streptococcus mutans nctc 10832 gave low levels of approximal caries, whereas streptococcus cricetus, streptococcus sobrinus and strep. mutans nctc 10449 gave high levels. the only strains to produce buccal surface lesions were strep. sobrinus and strep. cricetus. all strains were able to form dense plaque in the ce ...19892610617
iodination of newly synthesized thyroglobulin by frtl-5 cells is selective and thyrotropin dependent.this study shows that the fisher rat thyroidal cell line (frtl-5) can iodinate newly synthesized thyroglobulin. iodinated thyroglobulin was found intra- and extracellularly. both the synthesis of thyroglobulin and its subsequent iodination were found to be thyrotropin (tsh) dependent, with optimal activity at 10-100 microu tsh/ml. thyroglobulin was the only protein in the culture medium, that was iodinated with high specificity and in a tsh-dependent fashion. albumin, which was abundantly presen ...19892612732
anatomical and functional effects of estrogen-induced prolactinomas on the rat hypothalamus.although estrogen-induced prolactinomas have been widely studied, little attention has been accorded to local pressure effects of the tumor on the hypothalamus and portal vasculature. to portray the magnitude of this phenomenon, four groups of 12-13-week-old female fisher 344 rats were studied. group 1 was an intact control receiving a subcutaneously (sc) placed placebo pellet; group 2 was an ovariectomized control with a sc placed placebo pellet; group 3 was ovariectomized with a 10 mg sc place ...19892614531
nurse sues for "environmental sexual harassment". case in point: fisher v. san pedro peninsula hosp. (262 cal. rptr. 842--ca (1989)). 19892616768
[monoclonal antibodies. their usefulness in the diagnosis of malignant tumors of the digestive system].lately, there is a lot of interest in tumor markers, monoclonal antibodies and immunoscanning in the diagnosis and follow-up of certain cancers. the main objective of this study is to report our initial experience with the detection of specific antibodies and with the obtention of scan images. in 85.7% of patients with cancer and in 40% of patients with benign conditions, above normal values of cea were obtained. in 85.7% of patients with cancer and in 60% of patients with benign disease, above ...20062616981
[miller fisher syndrome: a report of 4 cases and review of the nosologic position].four typical cases of the miller fisher syndrome with external ophthalmoplegia, ataxia and generalized areflexia but no muscular weakness or sensory impairment of the limbs are reported. the nosological position of this disorder is reviewed.19892619616
discriminant functions.discriminant functions (dfs), first described by fisher in 1936, have been applied to the classification of microcytic disorders such as iron deficiency and heterozygous thalassemia. mathematically dfs are weighted linear combinations of variables. if the underlying assumption of multivariate normality is valid dfs provide the best possible classification. variables may need to be transformed before the df is derived. when two groups have to be classified it is easy to visualise the df. with one ...19892620093
the effect of marijuana smoke exposure on murine sarcoma 180 survival in fisher rats.fisher rats were treated for 28 or 60 days to multiple exposures to the smoke of marijuana or marijuana placebo cigarettes. primary, secondary and in some instances tertiary tumor implants were performed. murine sarcoma 180 tumor cells (7.5 x 10(7)) were implanted subcutaneously on day 1, 14 and 28 following initiation of smoke exposure (28 day studies) or on day 1, 14 after cessation of smoke exposure (60 day studies). tumor areas were measured on alternate days beginning on the second or third ...19892621317
phorbol esters and forskolin infused into midbrain central gray facilitate lordosis.several peptides, when infused into the mcg, facilitate lordosis in estrogen-primed female rats. since these peptides can act through camp and/or protein kinase c, and these second messenger systems have been implicated in neuromodulation, this study examined if pharmacological agents which stimulate these systems would facilitate lordosis. ovariectomized female fisher rats were given bilateral cranial cannulae targeted to the mcg, or cortex dorsal to mcg, and allowed at least a week to recover. ...19892623023
evaluation of cortisone-heparin and cortisone-maltose tetrapalmitate therapies against rodent tumors. i. biological studies.the antitumor activity of either cortisone-heparin or cortisone-maltose tetrapalmitate combination or both was tested against two animal tumor models. the first model was orthotopically implanted bladder tumor established in syngeneic fisher 344 rats. shrinkage and growth arrest of the tumors were induced by cortisone and amplified by its combination with either heparin or maltose tetrapalmitate (mtp). the second model was trocar implanted c3hba mammary tumor piece s.c. in syngeneic lps and mtp ...19892627134
evaluation of cortisone-heparin and cortisone-maltose tetrapalmitate therapies against rodent tumors. ii. pathological studies.pathological studies were undertaken in three tumor-host models which were subjected to cortisone based treatments. the first model was fisher 344 rats with established orthotopically implanted syngeneic bladder tumor. cortisone-herapin and cortisone-maltose tetrapalmitate (mtp) treatments induced focal areas of tumor necrosis and necrobiosis, whereas cortisone alone caused necrobiosis. the second model was c3hba mammary tumor fragments implanted subcutaneously in syngeneic mtp responder c3h/hen ...19892627135
natural killer cell activity in rats infused with intralipid.the effect of intralipid on the natural killer (nk) cell activity of healthy male fisher 344 adult rats was investigated. they were cannulated via the right jugular vein and continuously infused for five days with: normal saline plus heparin, 5% intralipid plus heparin, or 10% intralipid plus heparin. control groups comprised of cannulated rats receiving no infusion and rats undergoing no operative procedures. following the five-day infusion, rats were exsanguinated under ether anesthesia and mo ...19892628583
endogenous glutamate release from frontal cortex of adult and aged rats.glutamate (glu) is a major excitatory neurotransmitter in the frontal cortex. alterations in glu neurotransmission are present in a number of neurodegenerative diseases, however, little is known about the normal aging process of glu utilizing neurons. glu release, uptake and content were examined in the frontal cortex of adult (6 months old) and aged (24 months old) male, fisher 344 rats. these markers were used to assess the functional integrity of intrinsic and extrinsic glu utilizing pathways ...19892628777
[recurrent miller-fisher syndrome associated with brachial neuritis].the clinical and electrophysiological evolution of a 24-year-old patient with miller-fisher's syndrome and findings of mild peripheral neuropathy in the electromyographic study is reported. the patient had been treated six years previously for a similar disease and he recovered in 2 months. during the plasmapheresis therapy of the second episode he developed pain and weakness of the left shoulder girdle, and the emg was consistent with bilateral brachial neuritis. the disease had improved clinic ...19892629899
correlation between liver iron content and magnetic resonance imaging in rats.currently, serum ferritin concentration is the best noninvasive estimator of liver iron content. this study investigated the ability of magnetic resonance imaging to determine hepatic iron concentration. fisher rats were treated with either parenteral iron to increase levels of phlebotomy to lower them and achieved a wide range of liver iron concentrations. rats were imaged using a clinical whole body scanner at 1.5 tesla with a 15-cm helmholtz surface coil and a 23-cm field of view. the ratio o ...19892630845
[morphofunctional transformations of the blood vessels in the transplantation of syngeneic normal tissue and of a tumor].in 360 fisher rats dynamics of changes in blood vessels, the microcirculatory bed vessels included, have been investigated. an original model of the experiment at implantation of syngenic tissues of the fetus normal intestine and tumorous adenocarcinoma of the small intestine has been used. specific changes of the blood vessels have been revealed around and in the capsule of the implant, depending on their morphological reorganization. the blood vessels changes can serve as a prognostic sign of ...19892631644
guillain-barré syndrome and related conditions in victorian teaching hospitals 1980-84.cases of guillain-barré syndrome, its variants, and chronic inflammatory demyelinating neuropathy presenting during the period 1980-84 were identified through computer-based record systems. case notes were examined, and cases that did not meet standard criteria for diagnosis were excluded. a hundred and ten patients were identified, giving an annual adult incidence rate of 0.9/100,000 and a male:female ratio of 1.3:1. the majority of cases developed severe tetraparesis, but unusual presentations ...19892631660
stress ulcer susceptibility and depression in wistar kyoto (wky) a series of studies, wistar kyoto (wky) normotensive rats were more susceptible to water-restraint-induced stress ulcer as compared to spontaneously hypertensive rats (shr) fisher-344 (f344) and wistar rats. in these same studies, wky rats were also deficient in several behavioral tasks. the four strains were observed in the open-field test of emotionality and wkys were judged more emotional. in a study on "learned helplessness" wkys were more deficient in the acquisition of a shuttlebox esca ...19892634265
[bilateral paralysis of the 3d cranial nerve. miller-fisher syndrome]. 20042641103
inter- and intra-individual probability maps in eeg cartography by use of nonparametric fisher tests.the three types of non-parametric permutation fisher tests have been applied to inter-individual group studies and further to intra-individual multiple eeg recording sequences, providing computations of eeg probability maps testing two ordinal hypotheses. two examples of previous group studies with "eeg local cerebral activation" are given: mental computation in a group of 20 controls and caffeine effects versus placebo in a group of 10 controls. for the intra-individual study, two successive re ...20172641478
the neutrophil-activating protein (nap-1) is also chemotactic for t lymphocytes.t lymphocyte chemotactic factor (tcf) was purified to homogeneity from the conditioned media of phytohemagglutinin-stimulated human blood mononuclear leukocytes by a sequence of chromatography procedures. the amino-terminal amino acid sequence of the purified tcf showed identity with neutrophil-activating protein (nap-1). both tcf and recombinant nap-1 (rnap-1) were chemotactic for neutrophils and t lymphocytes in vitro supporting the identity of tcf with nap-1. injection of rnap-1 into lymphati ...19892648569
carotid stump syndrome: a colour-coded doppler flow study.colour-coded doppler flow imaging (angiodynography) was performed on 29 patients with 30 internal carotid artery occlusions. large internal carotid stumps were revealed as intravascular cul-de-sacs demonstrating vortices of blue flow reversal. large carotid stumps or significant external carotid stenoses were present in nine patients (9 arteries). such patients were significantly more likely to develop symptoms of cerebral ischaemia during follow up which averaged 18 months (p = 0.016; fisher ex ...19892653871
cryopreservation does not alter antigenic expression of aortic allografts.cryopreserved aortic homografts are reportedly viable, but no cross-matching or immunosuppression is utilized. alterations of the antigenic expression by cryo-preservation must be assumed. we designed a protocol to test this premise. fisher 344 rats served as recipients in all cases. lewis rats, a mildly disparate strain, were utilized as donors. four cohorts of animals were utilized. group i (n = 11) served as a "first set" control. all animals received a syngeneic skin graft. after 28 days an ...19892659897
chromosomal abnormalities in fetuses with omphalocele. significance of omphalocele contents.twenty-six consecutive fetuses with a sonographically detectable omphalocele and known karyotype were reviewed to identify risk factors that might be associated with chromosomal abnormalities. risk factors that were analyzed included contents of the omphalocele sac, maternal age, fetal sex, sonographically detectable concurrent anomalies, and any major concurrent anomaly. chromosomal abnormalities were found in 10 cases (38%) from trisomy 18 (n = 4), trisomy 13 (n = 4), trisomy 21 (n = 1), or 45 ...19892661855
[neurologic involvement in campylobacter infections. 5 cases].campylobacter are a newly recognized class of human infectious agents. campylobacter fetus subspecies fetus is a cause of sepsis in immunocompromized hosts. secondary neurological determinations, meningitis and meningoencephalitis appear to be rare. we report 2 cases, and 8 previously reported cases are reviewed. campylobacter jejuni appears to be a common bacterial pathogen causing a syndrome of enteritis. since 1982 it has been associated with guillain-barré syndrome (gbs). in one serological ...19892664975
length changes in dendritic networks of cerebellar purkinje cells of old rats after chronic ethanol treatment.dendritic networks of cerebellar purkinje neurons from aging ethanol-treated fisher 344 rats were analyzed for metric changes in terminal and internal segments of the networks. mean lengths of three categories of dendritic segments were determined. no significant metric changes in segment lengths were detectable immediately at the termination of 24 weeks of ethanol treatment, but significant changes were apparent after 8 weeks of recovery from ethanol treatment. return to a diet of standard labo ...19892665558
corticotropin-releasing factor: endocrine and autonomic integration of responses to stress.corticotropin-releasing factor, a 41-residue peptide, is established as the principal physiological regulator of the pituitary-adrenal axis. the neuroanatomic distribution of corticotropin-releasing factor and its receptors suggests that this peptide may be a neurotransmitter in pathways outside the hypophysiotropic zone. indeed, corticotropin-releasing factor demonstrates potent neuropharmacological actions that are independent of its pituitary effects. laurel fisher reviews the combined anatom ...19892667228
in praise of c. miller fisher. 19892668789
[considerations on the "one and half" syndrome].two cases with a clinical disorder of extraocular movements characterized by a horizontal gaze palsy in one eye and failure of adduction in the contralateral eye are described. one patient had a hemorrhagic lesion in the pontine tegmentum giving the classic "one and half" syndrome first described by fisher; the other a lung carcinoma metastatic to both cavernous sinuses. it is possible, even if not frequent, that peripheral lesions of the oculomotor nerves can manifest themselves with the same o ...20062669112
colorimetric in-situ hybridization in clinical virology: development of automated technology.automation of in situ hybridization is an important first step toward practical implementation of the widely recognized diagnostic potential of nucleic acid hybridization. our laboratory has concentrated its efforts towards automating colorimetric in situ hybridization on formalin-fixed paraffin-embedded tissue sections. we have capitalized upon the technology developed for the automation of immunohistochemistry (brigati et al. 1988) and are collaborating with fisher scientific in modifying the ...19892670458
molecular biology of friend viral erythroleukemia.friend virus clearly provides an important model for understanding the molecular biology of cancer. moreover, the most important aspects of the erythroleukemia can be caused by a single sffv infection in the absence of any helper virus. the sffv env gene encodes a membrane glycoprotein, gp55. this glycoprotein, when expressed on erythroblast surfaces, causes a constitutive mitogenesis. however, sffv infections only rarely increase the cell's self-renewal capability or abrogate its commitment to ...19892684547
fisherian and wrightian theories of speciation.fisher's theory of sexual selection, wright's shifting-balance theory, and recent models based on them are reviewed as mechanisms of animal speciation. the joint evolution of mating preferences and secondary sexual characters can cause rapid nonadaptive phenotypic divergence and premating isolation between geographically separated populations, or along a cline. extensive comparative data on drosophila species support the suggestion of r. a. fisher and t. dobzhansky that the evolution of mating p ...19892687093
Displaying items 601 - 700 of 17150