PMID(sorted ascending)
[fluorescence angiography as a basis for successful prophylactic and therapeutic light coagulation for diabetic retinopathy (author's transl)].the fluorescence angiogramme served as a basis for the plan of treatment and as a criterion of treatment success in 192 patients with diabetic retinopathy who underwent xenon-light coagulation between january 1971 and october 1972. in 64 patients this success could be statistically evaluated comparing the untreated partner eye according to the exact fisher-test. the rate of success of light coagulation showed itself to be statistically highly significant (p less than 0.01%) with regard to retina ...1978703143
site of lesion in fisher syndrome. 1978707991
histology and ultrastructure of the r-3327 c-f transplantable prostate tumor of cophenhagen-fisher rats.the r-3327 c-f tumor is an adenocarcinoma of the prostate maintained by serial transplantation in male copenhagen-fisher hybrid rats. the tumor is histologically different from other tumor sublines derived from the original r-3327 tumor discovered in 1961 in an aged copenhagen rat. light and electron microscopy have shown that the r-3327 c-f tumor contains a well organized glandular epithelium with myoepithelial cells and a continuous basement membrane, although epithelial cells were much less d ...1978711418
homicide and community-based psychiatry.the authors studied the records of all persons convicted of homicide or found not guilty by reason of insanity during the uears 1963 through 1975, 6 years before and after the opening of the community-based psychiatric facility, in albany county, new york. using the fisher exact probability test, a statistically significant increase was found for those found not guilty by reason of insanity (p = .041) and those with a history of mental illness found guilty (p = .036). other factors, including ag ...1978722309
freeze-fracture autoradiography: the in-vacuo coating technique.freeze-fracture autoradiography (ffa) was introduced in 1976 as a new method for electron microscopic autoradiography of diffusible compounds (fisher and branton, rix et al.). with the original technique, the film monolayer was applied to the cold specimen in a cryostat at atmospheric pressure. coating under these conditions did not exclude the risk of artifacts, mainly due to uncontrolled ice contamination of the cold specimen surface. a new method has been developed for coating the frozen spec ...1978738908
metabolic clearance of endogenous and radioiodinated thyroglobulin in rats.the basal concentration and metabolic clearance of radiolabeled and endogenous thyroglobulin (tg) were measured in normal male rats. serum tg concentrations (by ria) in sprague-dawley adult males ranged from 70-680 ng/ml (mean +/- sd, 218 +/- 177). in male fisher rats, basal serum tg concentrations were 32-263 ng/ml. the fractional disappearance rate of endogenously radioiodinated rat tg and of endogenous rat tg after thyroidectomy were both about 8%/h. the mcr of endogenously labeled tg was 2.4 ...1978744090
synthesis of some 11h-indolo[3,2-c][1,8]naphthyridines.the preparation of some 11h-indolo[3,2-c] [1,8]naphthyridines (v), having oxygen functions at positions 3 or 3 and 10 or 3 and 8, as in steroidal active compounds, is described. compounds (v) were obtained using the fisher indole synthesis. the preparation of the parent nucleus: 11h-indolo [3,2-c] [1,8]naphthyridines (v n) is also described. some compounds were subjected to pharmacological screening, but none was found to be significantly active.1978744236
fisher syndrome. presentation of a clinical case. 2004747139
s-phase fractions of breast carcinomas. relationships to morphology, estrogen and progesterone receptors, and early recurrence.analysis of the s-phase fractions (spf) measured by in vitro thymidine labeling, morphological appearances, and estrogen receptor (er) assays of primary invasive breast carcinomas demonstrated several interrelationships. lobular, mucinous, tubular, and adenocystic carcinomas consistently had low spf and were usually positive for er. the same was true for the carcinomas of no special histologic type [the not otherwise specified (nos) group of e. r. fisher including "infiltrating ductal" and undif ...1978747801
inbreeding effects in a coastal village and other parts of andhra pradesh.a survey was carried out among fisher-women in pallepalam, in nellore district of andhra pradesh, to determine the prevalence and pattern of consanguinity and its effects on fertility, mortality, and morbidity. of the 106 marriages investigated, 54.72% were consanguineous with predominant proportions of first cousin (36.79%) and uncle-niece (13.21%) marriages. the average inbreeding coefficients for autosomal and sex-linked genes were found to be 0.0405 and 0.0448 respectively. the differences b ...1978751385
[the fisher syndrome. symptoms and nosology of a special form of polyradiculoneuritis]. 1975772456
the rate of skin allografts within the prostate.there is good evidence demonstrating the absence of lymphatic drainage in the normal glandular prostate. in other organs, such as the brain and anterior chamber of the eye, this property is associated with an impaired response to foreign tissue antigens. we have examined the first set allograft survival of normal skin transplanted between strains of male inbred rats (lewis leads to fisher) to various sites including the prostate. the resulting data indicate that the prostate is not an immunologi ...1976786938
[in memory of e. f. fisher]. 1976792874
serotyping of pseudomonas aeruginosa isolates from patients with cystic fibrosis of the pancreas.pseudomonas aeruginosa isolates (173) from 144 patients with cystic fibrosis (cf) of the pancreas in seven hospitals were serotyped with the agglutination systems of homma (1974) and fisher et al. (1969). the two systems were complementary. strains from cf patients were much less likely to furnish a stable type on repetitive typing tests than strains from other patients. this was related to the frequent occurrence of mucoid p. aeruginosa strains. the 173 strains were divided among 11 homma serot ...1975809484
genetics of the rh-hr locus in analysis is attempted to throw more light on the inheritance of rhesus factor in humans and the fisher-race and wiener's concepts are respectively evaluated. it is claimed that the rh-hr locus is not comprised of the recombination of c, d, e, c and e genes, much less the help of the auxiliary (d) which merely appears to be a conventional approach derived from an even principle of recombination for a polyhybrid cross. as for wiener's rare or common mutants of rh-hr in humans and the emergence ...1975817554
role of galactose in the antigenic properties of thyroglobulin.thyroglobulins (tg) from a "hot" human thyroid nodule and from fisher rats have been purified and the effects of progressive removal of sialic acid and galactose on the immunoreactive properties of the proteins were studied. terminal sialic acid and galactose were released by stepwise hydrolysis with neuraminidase and beta-galactosidase. agalacto-tg shows a slower electrophoretic mobility than native tg, but in polyacrylamide gel electrophoresis and immunoelectrophoresis it migrates in the same ...1976822669
measurement of acute and chronic behavioural effects of methamphetamine in the mouse.a simple and reliable method was developed for rating the dose-related behavioural effects of methamphetamine in male swiss albino mice for acute or chronic drug treatment. this procedure was based on a frequency count of certain behaviours made at 15-min intervals over a 90-min period following drug administration. the fisher randomization procedure was adapted to analyze behavioural data for the chronic studies. clear-cut, dose-related behavioural responses occurred following acute (+)-methamp ...1976823582
the descriptive and comparative postcranial osteology of marten (martes americana turton) and fisher (martes pennanti erxleben): the appendicular skeleton. 1977837275
the forelimb musculature of marten (martes americana turton) and fishes (martes pennanti erxleben). 1977837281
erythrocyte membrane plaques from rats with magnesium deficiency.this study investigated the anemia of dietary magnesium deficiency in inbred fisher white rats using freeze-fracture electron microscopy. the plasma membranes of erythrocytes from animals receiving two different magnesium-deficient and control diets were observed at weekly or biweekly intervals for 6 wk. the earliest changes were small plaques on the external surface (es) and fracture face (pf) of erythrocyte plasma membranes, which occurred after 2 wk of either magnesium-deficient diet. these p ...1977843624
effects of a zinc deficient diet upon fluid intake in the rat.zinc deficient rats demonstrate an increased intake of sodium chloride (nacl) containing solutions as compared to normal rats, presumably related to decreased taste acuity. the purpose of this study was to determine if zinc deficient rats would show altered intake of other solutions since changes in nacl intake may be reflective of serious pathophysiologic processes not related to taste. eight littermate pairs of inbred fisher cdf rats, 29 days of age, were divided into two groups and individual ...1977845680
is the biomechanical principle of 'antagonistic compensation' valid also on the genetic level?according to 'antagonistic compensation', appendicular bones rendered hypofunctional by surgical means, become shorter and more robust. in normal buffalo rats, appendicular bones are short and very robust and in fisher rats they are long and gracile. total body constitution is robust in buffalo rats and gracile in fisher rats. in grl rats, appendicular bones are short but body constitution is gracile and the robusticity of the appendicular bones is intermediate between fischer and buffalo rats. ...1977848266
upper lid jerks in the fisher syndrome. 1977872845
distribution of 99mtc-1-thioglucose in rats: effect of administration route on pancreatic specificity.tissue distribution of 99mtc-1-thioglucose was studied in inbred albino fisher rats. high levels of radioactivity were observed in the kidney with concurrent low pancreatic levels and pancreas/liver ratios of 0.4 following intravenous administration of the agent. high pancreatic concentration were observed with pancreas/liver ratios of 4.0 after intraperitoneal administrations. future studies on pancreatic radiopharmaceuticals should avoid production of artificially high pancreatic values by int ...1977887787
congressman james j. florio (d-nj). fisher scientific address. tgeneral session, 45th american society for medical technology annual meeting. 1977888859
the vehicle tray revisited: the use of the vehicle tray in assessing allergic contact dermatitis by a 24-hour application method.over 700 patients were screened by patch testing for sensitivity to the components of a vehicle tray from july 1974 through june 1976 at the mayo clinic. a modified version of the vehicle tray originally suggested by fisher et al. (1971) was used, containing 14 substances commonly found in vehicles. patches were applied for 24 rather than the usual 48 hours. our percentage of reactivity compares favorably with the 48-h application method, thus demonstrating the efficacy of this time-saving techn ...1977891174
the evolution of epistasis and the advantage of recombination in populations of bacteriophage t4.experiments reported here test two hypotheses about the evolution of recombination: first, the fisher-muller concept that sexual organisms respond to selection more rapidly than do asexual ones, and second, that epistasis is more likely to evolve in the absence of recombination. populations of bacterio-phage t4 were selected by the drug proflavine in discrete generations and the change in mean population fitness was monitored. three separate selection series yielded results supporting the fisher ...1977892424
effect of oil composition on both adjuvant-induced arthritis and delayed hypersensitivity to purified protein derivative and peptidoglycans in various rat strains.we confirmed that, when immunized with a conventional complete freund adjuvant (water in oil), lewis rats were highly susceptible to adjuvant arthritis, fisher rats were less susceptible, and buffalo rats were much less susceptible. however, mycobacterial delipidated cells in squalane (squalane-type adjuvant) produced severe arthritis with almost 100% incidence even in the less susceptible rat strains except for buffalo rats. with regard to an immune response, freund complete adjuvant induced st ...1977892904
[numerical procedure for the decomposition of biorhythmic processes into harmonic oscillating components].a numerical procedure for decomposition of time series into inherent periodic nonstochastic components in form of harmonic oscillations will be explained. it is supposed that the rhythmic process is built up by these harmonic oscillating components and by a stochastic component. the procedure is a combination of harmonic analyses for intervals with different numbers of measured values with a significance test elaborated by r.a. fisher for the greatest component in the spectrum. the parameter val ...1977914007
[from phlebothrombosis to the postthrombotic syndrome].the same pathomechanism causes both thrombosis of the superficial and deep veins. for practical purposes one may separate phlebothrombosis of bed-patients and that of out-patients. superficial phlebothrombosis and thrombophlebitis of the out-patients heal in shorter time by compression according to heinrich fisher. patients should not be immobilized. phlebothrombosis of the bed-patient should be reserved to clinical therapy including fibrinolysis, thrombectomy and anticoagulants. the post-thromb ...1977914157
peripheral nerve conduction in miller fisher syndrome.two cases of acute ophthalmoplegia, ataxia, and arreflexia with high csf protein are reported (miller fisher syndrome). detailed emg and nerve conduction studies showed abnormal conduction in peripheral sensory fibres from the initial stages of the illness in both patients. careful review up to 10 months after the onset was required to document the sensory conduction abnormality properly in one of them. the electrical findings did not differ from those that can be seen in the guillain-barré synd ...1977925702
polyradiculitis (landry-guillain-barré syndrome) with total external ophthalmoplegia: ophthalmoplegia is described in an eight-year-old boy with polyradiculitis. the findings suggest central nervous system involvement. it is postulated that this case represents an entity intermediate between the miller-fisher and the landry-guillain-barré syndromes, with features of brain-stem encephalitis.1976939350
creativity and body image boundaries.descriptions of the creative individual or the individual who can regress in the service of the ego seem to parallel fisher and cleveland's (1968) description of the high barrier individual: well-integrated; self-sufficient, but often outgoing and communicative; and able to experience a full range of sensation and emotions without neurotic anxiety. the relationships between barrier and five measures associated with creativity were investigated, using 100 paid male college student volunteers. the ...1976943498
estimates of the heritability of serum lipoprotein and lipid concentrations.heritability (h2) of a serum lipid or a serum lipoprotein concentration is the proportion of variability in that concentration, among individuals, which is associated with heredity. we derive a familiar formula for estimating heritability (h2) from a simple linear model for inheritance. the formula was implied by fisher (1918) and by wright (1921); it was derived from a consideration of variances by jensen (1967), and from a consideration of path coefficients by rao et al. (1974). the estimate o ...1976945139
feminization of hepatic s metabolism in male rats with a transplanted (mtt/f4).after transplantation of mtt/f4 pituitary tumor cells to male rats of the fisher strain, the masculine type of hepatic steroid metabolism was changed into a feminine pattern of enzyme activities. liver metabolism of steroid hormones in female rats was relatively unaffected following transplantation of pituitary tumor cells. futhermore, extract from mtt/f4 tumors and "autonomous" pituitary tissue increased the 5alpha-reductase activity of hepatoma cells in the culture (htc cells) at subsaturation ...1976947549
metastrongyles (nematoda: metastrongyloidea) of fisher (martes pennanti) from ontario. 1976949653
a model for assortative is shown that a generalization of the hardy-weinberg law of the proportions of genotypes of the kind given by wright (1922) is maintained in equilibrium by a pattern of assortative mating suggested by fisher (1918) and elaborated by malécot (1939, 1948).1976952488
composite sampling certain types of materials, such as bags of fertilizer, or subsampling large quantities of water, as might be done in investigating the density of plankton in certain environmental situations, it is customary to composite the samples. that is, several samples are drawn, mixed into a composite sample, and a sample taken from the composite is then used to determine relevant characteristics of the population. in this paper the results of brown and fisher [1972] are extended to more comp ...1976953130
[letter: comments on the paper by j. ullrich: "the fisher-syndrome. symptomatology and nosology of a special form of polyradiculoneuritis" (this j., 46, 417-421 (1975)]? 1976958557
constitution and body proportions in different strains of rats. a study of race formation in breeding isolates.(1) there are considerable differences in body constitution in different strains of rats, ranging from very robust to very gracile forms. the differences are greater in the larger males than in the smaller females. (2)craniofacial and postcranial proportions of the trunk in domesticated strains of rats differ either uniformly or mosaically from the wild form. (3)nasal shape differs greatly in rats ranging from extreme leptorrhine to extreme platyrrhine forms, giving a total range greater than in ...1976961343
the evolutionary advantage of recombination. ii. individual selection for recombination.based on the fisher-muller theory of the evolution of recombination, an argument can be constructed predicting that a recessive allele favoring recombination will be favored, if there are either favorable or deleterious mutants occurring at other loci. in this case there is no clear distinction between individual and group selection. computer simulation of populations segregating for recessive or dominant recombination alleles showed selection favoring recombination, except in the case of a domi ...1976971808
age-related changes in the lipid metabolism of fisher 344 rats.lipid metabolism of male fisher 344 rats aged 2-24 months was studied. serum and liver cholesterol levels did not display the age-related gradual increase seen in other rat strains. an increase in the serum plus liver cholesterol pool from 2 to 6 months was followed by a plateau through 18 months and then another increase at 24 months of age. the triglyceride pool increased from 2 to 6 months and then remained unchanged through 24 months of age. cholesterol synthesis from acetate decreased 50% b ...1976972580
automated rodent respiratory monitor and histogram computer--a preliminary report.the system described in this paper was designed to monitor total inhaled volume (v), tidal volume (vt), and respiratory frequency (f) of fisher rats before, during, and after exposure to cigarette smoke. the systems consists of three major subsystems: plethysmograph, analog signal conditioner, and histogram computer. the volume type whole body plethysmograph incorporates a rubber nose seal. tidal flow rate (v) from the tube, measured by a pneumotachometer, is integrated by the signal conditionin ...1976977275
evidence for dimensional independence in short-term memory of retarded individuals.this experiment was designed to assess the relative importance of dimensional similarity between test and interpolated problems and absolute difficulty of interpolated material as variables influencing short-term retention in the discrimination learning of retarded persons. twenty moderate-to-borderline retarded individuals were taught a mixed series of two-trial discriminations consisting of: (a) relatively easy multidimensional ("junk") problems and (b) more difficult, form-relevant dotpattern ...1976985634
androgen receptor dependent and independent activities of testosterone on hepatic microsomal drug metabolism.administration of testosterone for 6 days to intact female and castrate male balb/cj mice stimulated hepatic microsomal ethylmorphine n-demethylase activity and cytochrome p-450 content by 50-75%. testosterone also stimulated hepatic microsomal nadph-oxidase activity, but to a lesser degree. to probe the mechanism of this effect of androgens, two antiandrogens (cyproterone acetate and flutamide) were employed. since cyproterone acetate was a potent stimulator of hepatic microsomal ethylmorphine ...1976991826
[cross resistance in tumor cells and staphylococci with respect to anthracycline-group antineoplastic antibiotics].the variants of the tumor cells of fisher lymphadenosis, strain l-5178 and staph. aureus resistant to rubomycin simultaneously became partially less sensitive to adriamycin. sensitivity to karminomycin in the rubomycin resistant strains did not practically change as compared to the sensitivity of the initial strains. sensitivity to adriamycin and rubomycin in staph. aureus decreased 67 and 4 times respectively after 7 passages on media with increasing concentrations of adriamycin, while sensitiv ...1976999240
[cranial polyradiculitis or the so-called fisher syndrome].in the light of 3 personally observed cases a description is given of polyradiculitis cranialis or socalled fisher's syndrome, a separate form of guillain-barre-strohl polyradiculitis. it is a combination of acute ataxia, areflexia and ophthalmoplegia. the cause is probably an immunological reaction to a harmless infectious disease. reversible or limited demyelination is assumed. the demyelination occurs particularly in the peripheral nerves and their spinal roots, but also in the spinal-cerebel ...19761013715
the acute toxicity of four herbicides to 0-4 hour nauplii of cyclops vernalis fisher (copepoda, cyclopoida). 19761016756
winds of change on fishers lane. 19761032964
[carcinoid papillomatosis].papilomatosis carcinoides, presents clinical and histological characteristics that may be authentically described as a transition state between the benign papillomatous proliferations and spindle cell carcinoma. it involves a series of clinical conditions, that are described with different names that correspond to the condyloma accuminatum gigantum. [buschke and lowenstein) wartic carcinoma [ackerman], papillomatosis oral florid [rock and fisher], carcinomatoid [gilbert] profuse conjuntival papi ...19761035386
[transient global amnesia - a paroxysmal amnestic syndrome (author's transl)].the syndrome of transient global amnesia is clinically characterized by a disorder of the ability to form memory engrams, appearing suddenly and lasting for several hours. since the first papers on this syndrome by bender (1956) and fisher and adams (1964) approximately one hundred cases of transient global amnesia have been described. symptomatology, course, somatic findings and differential diagnosis are discussed with consideration of the literatur and three own observations. regarding the et ...19751041711
[health education among fishers]. 19761044583
hepatic phenylalanine 4-monooxygenase is a phosphoprotein.phenylalanine hydroxylase [phenylalanine 4-monooxygenase; ec; l-phenylalanine, tetrahydropteridine:oxygen oxidoreductase(4-hydroxylating)] isolated from rat liver is a phosphoprotein containing approximately 0.31 mumol of protein-bound phosphate per mumol of subunit (50,000 molecular weight). when the enzyme is further phosphorylated in the presence of atp and a 3'5'-cyclic-amp-dependent protein kinase (ec; atp:protein phsophotransferase), an additional 0.7 mumol of phosphate ...19761064028
is sex maintained to facilitate or minimise mutational advance?there are two alternative hypotheses for the selective advantages of sex: (i) the "fisher-muller" model:sex facilitates evolutionary adaptation to chaning environments. (ii) the "rachet" model: sex minimises the mutational load. the relative importance of these hypotheses is discussed with reference to (a) comparative data on sexual and asexual reproduction, (b) the timing of sex in species with asexual/sexual alternation, (c) the advantages of haploid/diploid alternation, (d) the disadvantage a ...19761064588
selective effect on t and b cell subpopulations in rat lymphoid organs after urethan vitro phytohemagglutinin (pha) and concanavalin a (con a) responsiveness of thymus and bone marrow cells, and e, ea, and eac rosette-forming cells (e, ea, eac) of these organs and spleen were studied in fisher rats at various time intervals following a carcinogenic treatment with urethan (ur). immediately after treatment, organ cellularities were drastically reduced with a progressive recovery as time passed. 1 day after treatment, the response of thymocytes to pha showed a fourfold increase ...19761083833
nightingale letter to alice fisher in philadelphia. 19761106269
haploidploidy and the evolution of the social insect.halminton (1) was apparently the first to appreciate that the synthesis of mendelian genetics with darwin's theory of natural selection had profound implications for social theory. in particular, insofar as almost all social behavior is either selfish or altruistic (or has such effects), genetical reasoning suggests that an individual's social behavior should be adjusted to his or her degree of relatedness, r, to all individuals affected by the behavior. we call this theory kinship theory. the s ...19761108197
oxidative energy metabolism in germ-free and conventional rat liver mitochondria.the adp:o ratios and state 3 (adp-stimulated) and state 4 (controlled) rates of succinate, beta-hydroxybutyrate, isocitrate, glutamate, pyruvate + malate, alpha-ketoglutarate, and ascorbate + n,n,n',n'-tetramethylphenylenediamine (tmpd) oxidation were examined in liver mitochondria from germ-free and conventional rats of both lobund wistar (100-day-old) and fisher (120-day-old) strains. the state 3 respiration rates of isolated mitochondria from germ-free and conventional rats were comparable ex ...19751122009
a modification of the jump-flinch technique for measuring pain sensitivity in rats.the jump-flinch procedure provides a sensivite alternative to the hot-plate and tail-flick procedures. analysis of the components of motor responses to increasing intensity of foot shock presentation has allowed the observational discrimination of five reliably elicited categories of unlearned responses to inescapable foot shock. morphine sulfate differentially altered response category thresholds in rats. response category thresholds also differed between wistar and fisher strain rats in analge ...19751129354
a comparison of two heated water-bath humidifiers.the performance of two heated water-bath humidifiers was examined in terms of airway temperatures and humidities. these were the simple heated tank (marshall and spalding, 1953) and the fisher and paykel no. 328 (spence and melville, 1972), both of which had the potential to deliver gases at temperatures above 40 degrees c, and with a moisture content in excess of 50 mg/litre. the major advantage of the no. 328 was its heating wire in the delivery tube. this lessened or prevented condensation wi ...19751130644
[renal effects and metabolism of sevoflurane in fisher 3444 rats: an in-vivo and in-vitro comparison with methoxyflurane].sevoflurane, 1.4 per cent (mac), was administered to groups of fischer 344 rats for 10 hours, 4 hours, or 1 hour; additional rats received 0.5 per cent methoxyflurane for 3 hours or 1 hour. urinary inorganic fluoride excretion of sevoflurane in vivo was a third to a fourth that of methoxyflurane. however, using hepatic microsomes, sevoflurane and methoxyflurane were defluorinated in vitro at essentially the same rate. the discrepancy between defluorination of sevoflurane and methoxyflurane in vi ...19751147310
host-parasite relationship of bulinus forskalii (ehrenberg) and schistosoma intercalatum fisher 1934, from cameroun.the susceptibility of 13 different b. forskalii strains from zaire, cameroun, gabon, senegal, rhodesia and tanzania and b. reticulatus wrighti aden has been tested to infection with schistosoma intercalatum from cameroun. the most common prepatent period was 23-28 days. b. forskalii from zaire, cameroun and gabon were excellent intermediate hosts with infection rates varying from 59-0 to 97-4% and with very low death rates, 0-28-4%. the strains from senegal and rhodesia had infection rates from ...19751151052
[a case of fisher-evans syndrome]. 19751170487
transport of deutherium oxide across isolated rat small intestine.1. transport of deuterium oxide from a luminal perfusate containing 1% d2o was studied in fisher & gardners (1974) isolated preparation of perfused rat small intestine. 2. the kinetics of appearance of d2o in the intestinal secretion at the serosal surface fitted well to a single exponential function. 3. the steady-state concentration of d2o in this secretion was not significantly different from the concentration in the luminal perfusate. 4. the total tissue water contained d2o at a concentratio ...19751177106
observations on possible autoimmune therapeutic effects in experimentally produced rat bladder tumors.autoimmune response to normal and tumor bladder tissues in fisher/furth rats were obtained. the reaction consisted mainly of severe pericystitis and hemorrhagic lesions. the cellular infiltrate was predominantly lymphocytic including also plasma cells and histiocytes. serological tests indicated development of host immunological response. 15 of 33 rat bladder tumors involuted entirely in the course of the autoimmune reaction.19751189123
fusion of the distal femoral epiphysis in male and female marten and fisher. 19751192293
synthetic capacity and cell metabolites of bile duct obstructed rat livers. effect of free and conjugated dihydroxy bile acids.morphologic alterations in liver cells after bile duct ligation are well known and documented in numerous reports. biochemical studies concerning metabolic changes in cholestatic liver are rare. therefore, in this study, liver cell metabolites and the capacity of the perfused cholestatic rat liver to produce glucose, urea and ketone bodies were measured. in addition the influence of dihydroxy bile acids on normal and bile duct ligated rat livers was studied. concentrations of adenine nucleotides ...19751199667
[development of resistance in fisher lymphadenosis cells to dipin and bruneomycin when these preparations are used separately and in combination].it was shown that dipin and bruneomycin resistant tumor cells appeared in mice with transplanted lymphadenosis after 10 passages on single use of the drugs. when the drugs were used in combination, no lymphadenosis cells resistant either to bruneomycin, or to dipin and their combination were found. the combined use of the drugs prevented development of resistance to them in the lymphadenosis cells at least during 10 passages on mice. the data on the possible prevention of the resistance developm ...19751211895
conditions for the existence of clines.a very general partial differential equation in space and time satisfied by the gene frequency in a monoecious population distributed continuously over an arbitrary habitat is derived. the treatment is restricted to a single diallelic locus in the absence of mutation and random drift, and it is supposed that time is continuous, births and deaths occur at random, and migration is independent of genotype. with the further assumptions that migration is isotropic and homogeneous, the population dens ...19751232026
[the fisher-evans syndrome. report on 5 cases]. 19751239821
influence of age on size and number of fat cells in the epididymal depot.the extensive literature on the effect of rat age on the size and number of adipocytes in adipose tissue depots relates solely to young developing rats and young adults. therefore a study was carried out in our laboratory on the cellular characteristics of the epididymal depot of the fisher 344 strain of rats through virtually the entire life-span. collagenase digests of this depot prepared from rats of 9, 13, 26, 52, 104, and 130 wk of age yield a population of cells with diameters greater than ...19751239957
miller-fisher polyneuritis. 19751240634
an evaluation of the role of leukocytes in the pathogenesis of experimentally induced corneal vascularization. iii. studies related to the vasoproliferative capability of polymorphonuclear leukocytes and lymphocytes.studies in the past have suggested that leukocytes are a prerequisite to corneal vascularization. to test this hypothesis further, experiments were conducted to determine whether the intracorneal instillation of polymorphonuclear leukocytes, lymphocytes, or components of leukocytes would induce a corneal vascular ingrowth. these cells or cellular fractions were injected intracorneally into fisher albino rats whose circulating leukocytes had been depleted by total body x-irradiation. polymorphonu ...19761247083
the morphology of the femur in marten and fisher. 19761260574
[study using the probit-analysis method of the process of increasing resistance to dipin and bruneomycin in fisher l-5178 lymphadenosis cells in experiments on animals].the study of the process of resistance induction in the cells of lymphadenosis to dipin (subline l-5178/d) and bruneomycin (subline l-5178/b) showed that with increasing of the resistance relation between the drug dose and the antitumor effect gradually faded. it was found that only at the first stages of induction of the resistance increase may be found by comparison of values ed50 and ed70 of the lymphadenosis sensitive strain and its resistant sublines. the probit-analysis method provided reg ...19761275469
cloning and surface expression of pseudomonas aeruginosa o antigen in escherichia a step toward developing recombinant oral vaccines, we have explored the feasibility of expression of o polysaccharide antigens from pseudomonas aeruginosa by escherichia coli. we cloned in e. coli hb101 a 26.2-kilobase dna fragment from p. aeruginosa strain pa103 that specifies the production of the o polysaccharide of fisher immunotype 2 (it-2) strains. the recombinant organism incorporated the p. aeruginosa it-2 o polysaccharide onto the core of the e. coli lipopolysaccharide (lps). transf ...19921279692
[angiogenesis induced by rat glioma cells in vitro].angiogenesis induced by rat glioma cells was examined in vitro using a double chamber co-culture system. cultured microvascular endothelial cells from fisher 344 rat brain, rat c6 glioma cells and rat t9 gliosarcoma cells were used for this study. endothelial cells, cultured on type i collagen, formed capillary-like structures. in the co-culture system, c6 glioma cells promoted this formation. on the other hand t9 gliosarcoma cells had no effect on it. the supernatants of c6 glioma cells and t9 ...19921280347
[immunotherapy in ocular diseases].basic and clinical studies on immunotherapy in immune-mediated ocular disorders, i.e. uveitis, allograft rejection in corneal transplantation and allergic conjunctivitis, were carried out using a variety of immunosuppressants, including immunophilin ligands (fk506 and cyclosporine). 1. in an animal model for uveitis, experimental autoimmune uveitis (eau), immunophilin ligands were demonstrated in the rat and monkey to have unique immunological activities: (1) intense and prolonged suppression of ...19921283052
glutamine facilitates chemotherapy while reducing toxicity.dose intensification of chemotherapy is thought to increase survival. with recent advances in hemopoietic cell modulators such as granulocyte colony stimulating factor, the limiting toxicity of intensifying chemotherapeutic regimens has become the severity of the associated enterocolitis. in animal models, glutamine protects the host from methotrexate-induced enterocolitis. this study evaluates the effects of a glutamine-supplemented diet on the tumoricidal effectiveness of methotrexate. sarcoma ...19921287230
[disseminated intravascular coagulation induced by endotoxin in rabbits: effect of treatment with t-pa and urokinase].to assess the therapeutic efficacy of agents capable of stimulating the fibrinolytic system, such as tissue plasminogen activator (t-pa) and urokinase (uk) on endotoxin-induced disseminated intravascular coagulation (dic) in the rabbit.19921293794
lack of association of the alpha-1-antitrypsin piz allele with rheumatoid arthritis or with its extra articular complications.piz allele frequencies were defined by pcr amplification and hybridization using a piz sso (sequence specific oligonucleotide) probe. the groups studied included 64 normal controls, 104 subjects with rheumatoid arthritis (ra) without any extra-articular features, 29 of whom had severe arthritis and 31 of whom had mild ra. the extra-articular subsets include 41 with ra-bronchiectasis (ra-br), 21 with bronchiectasis without ra (br), and 23 with ra and pulmonary fibrosis (ra-pf). fifteen ra subject ...20041294360
[acute early rejection in renal transplantation].the incidence of early acute rejection (first two months after surgery) was evaluated in a group of 150 kidney transplants, receptors, who were followed for more than three months. ninety nine were transplanted with kidney from a cadaver donor and 51 with living donor. one hundred forty two patients were treated with triple immunosuppression therapy (cyclosporine, prednisone and azathioprine). the incidence of early acute rejection was significantly higher in cadaver kidney receptors (34% vs 19. ...19921295580
[safety of cholecystectomy by laparotomy in elective situation and in emergency].cholecystectomy is the only effective treatment of gallbladder stones. a retrospective study was carried out on results of 658 cholecystectomies by laparotomy without choledochotomy performed between january 1987 and december 1989, to determine morbidity and mortality of elective and emergency surgery and by age. operations for tumors of the gallbladder and choledolithiasis were not included in the analysis. during this period, cholecystectomy was performed electively in 387 cases and under emer ...19921295909
susceptibility of various animals to pneumocystis carinii infection.pneumocystis carinii (pc) is an important opportunistic pathogen of immune compromised hosts, and is known to infect various animals. the present study observed the infection status of 6 mammals and 3 strains of albino rats with pc after suppression of their immunity. methyl-prednisolone was injected once a week and tetracycline was supplied with water for 5 to 21 weeks. hamsters, guinea pigs, rabbits, dogs, cats and pigs were negative by impression smear, and only the rats were found infected b ...19921297418
transmission modes of pneumocystis carinii among rats observed by karyotype observe the transmission patterns of karyotype of pneumocystis carinii (pc) by rat colonies, three strains of rats, sprague-dawley(sd), wistar(w) and fisher(f) from various animal vendors, were suppressed of their immunity by injection of methyl prednisolone. they were kept for 5 to 13 weeks in 3 different animal rooms, a, b, and c. the purified organisms were prepared in low melting point agarose gel by embedded lysis method for pulsed field gel electrophoresis. field inversion gel electroph ...19921297419
[transient global amnesia. case report].all memory disturbances, especially those developing suddenly, cause anxiety of the patient. transient global amnesia is a form of amnesia of interest in many aspects. the amnesia was described in 1964 by fisher and adams, and as yet about 1000 cases have been reported. middle aged or elderly patients prevail. the attack of amnesia lasts from several to about 20 hours and begins suddenly being regarded as mental confusion. the amnesia covers recent and remote events in many years. during the att ...20151301517
[tumor ablation with focalized ultrasound. in vivo experiment with prostatic adenocarcinoma r3327 mat-ly-lu].ultrasound can induce tissue lesions by a combination of thermal and mechanical effects related to the tissue absorption of the energy emitted at the focal point of the transducer. the effects of focused ultrasound were studied in vivo in fisher/copenhagen hybrid rats bearing dunning r3327 experimental prostatic carcinoma. the experimental tumour was transplanted by subcutaneous injection into the abdomen of 20 mg of tumour tissue derived from the mat-ly-lu strain. treatment was performed under ...19921302056
isolation and characterization of two benzene-derived hemoglobin adducts in vivo in rats.the present study was aimed at the characterization of the major adducts formed by reaction of the metabolites of [14c]benzene with rat hemoglobin in vivo. groups of 12-week-old male fisher rats received i.p. injections of a single dose of 10 mmol/kg body weight or three equal daily subdoses of 3.3 mmol/kg body weight of [14c]benzene. high-performance liquid chromatographic analysis of strong acid hydrolysates of the [14c]benzene-modified globin indicated that the two major adducts in rats cochr ...19921303132
endogenous intestinal metallothionein possibly contributes to the renal accumulation of low levels of dietary cadmium chloride, cadmium accumulates directly in the kidneys and not in the liver. as dietary cadmium induces intestinal metallothionein (mt), intestinal cdmt complexes could be at least partly responsible for the renal accumulation of oral cadmium. for this to be possible, however, serosal release of mucosal cdmt would be required. to test this hypothesis, we perfused isolated rat small intestinal segments (fisher-parsons method) in an attempt to demonstrate the releas ...19921303945
[frequency of external congenital abnormalities in abortions].the purpose of this study was to calculate the incidence of external birth defects found in 1,650 aborted fetuses studied from september 1978 to february 1983 at the department of gynecology and obstetrics of the university hospital "dr. josé eleuterio gonzález" of the u.a.n.l. medical school. ninety five of fetuses had external birth defects and 85 had abnormalities in annexes. the fisher exact test was applied to find the relationship between these abnormalities; no relationship was found. 67. ...19921304764
natural course of acute and chronic monophasic inflammatory demyelinating polyneuropathies (idp). a retrospective analysis of 266 cases.the present study analyses one of the largest idp series published as yet: 266 cases, hospitalised between 1950 and 1983, conventionally treated and uniformly supervised. there was gbs in 84%, chronic idp in 13%, polyneuritis cranialis in 1.5%, miller fisher and predominantly sensory neuropathy in 0.8% each. numerous features including preceding events, course and outcome have been investigated. latencies between onset and maximal deficit lacked (expected) bimodality. sensory involvement was sev ...19921316709
the effects of freeze-drying on the potency and stability of live varicella virus vaccine.investigations into methods for improving the potency and stability of live varicella-zoster virus (oka strain) vaccines have included the use of different lyophilization procedures which yielded products with different moisture levels. three procedures were used: an 8-hour controlled-vacuum (0.47 mbars) procedure, a 14-hour controlled-vacuum (0.14 mbars) procedure, and a 48-hour high-vacuum (less than 0.07 mbars) procedure. samples were stored for 24 months at -24 degrees c, -15 degrees c (in a ...19921317307
[paraneoplastic miller-fisher syndrome?]. 19921317716
a case of miller fisher syndrome: atypical findings and therapeutic considerations.the miller fisher syndrome (mfs) is generally considered to be a disease of the peripheral nervous system. in some cases contemporary involvement of the central nervous system has been described (cns). we report a case in which it was possible to prove involvement of cranial nerves vii, viii, ix and x and to exclude cns involvement. we discuss the possible role of early plasmapheresis treatment on disease evolution.19921318288
effects of the combination of lipopolysaccharide-specific monoclonal antibodies and sparfloxacin against pseudomonas aeruginosa pneumonia in neutropenic mice.the effects of the combination of a murine monoclonal antibody (mab) specific for the o side chain of pseudomonas aeruginosa fisher immunotype 1 lipopolysaccharide and sparfloxacin in a neutropenic mouse model of p. aeruginosa pneumonia were examined. under the condition that neither mab at a dose of 500 micrograms per mouse administered intravenously nor a suboptimal dose of oral sparfloxacin (5 mg/kg of body weight) protected mice from challenge with a fatal dose, the combination therapy with ...19921324643
genetic engineering of redox donor sites: measurement of intracomplex electron transfer between ruthenium-65-cytochrome b5 and cytochrome c.the de novo design and synthesis of ruthenium-labeled cytochrome b5 that is optimized for the measurement of intracomplex electron transfer to cytochrome c are described. a single cysteine was substituted for thr-65 of rat liver cytochrome b5 by recombinant dna techniques [stayton, p. s., fisher, m. t., & sligar, s. g. (1988) j. biol. chem. 263, 13544-13548]. the single sulfhydryl group on t65c cytochrome b5 was then labeled with [4-(bromomethyl)-4'-methylbipyridine] (bisbipyridine)ruthenium2+ t ...19921324708
growth behavior of low passage cultured cells derived from human non-small cell lung carcinoma in deepithelialized rat tracheas transplanted into nude mice.proliferation behavior of six low passage cell lines derived from human non-small cell lung carcinoma was investigated both by cell inoculation into deepithelialized fisher 344 rat tracheas xenotransplanted into nude mice and by direct cell injection into the subcutis of nude mice. in the tracheal transplants, all the cell lines showed a comparable or higher degree of differentiation than in the primary lesion, while most cell lines showed a lower degree of differentiation in the mouse subcutis. ...19921325571
herpes simplex virus type 1 dutpase mutants are attenuated for neurovirulence, neuroinvasiveness, and reactivation from latency.herpes simplex virus type 1 (hsv-1) encodes a dutpase which has been shown to be dispensable for normal viral replication in cultured cells (s. j. caradonna and y. cheng, j. biol. chem. 256:9834-9837, 1981; f. b. fisher and v. g. preston, virology 148:190-197, 1986). however, the importance of this enzyme in vivo has not been determined. in this report, hsv-1 strain 17 syn+ and two isogenic engineered dutpase-negative mutants were characterized in the mouse model. both mutants replicated with wi ...19921328686
effects of wheat bran on blood and tissue hormone levels in adult female rats.the protective effect of dietary fiber on breast cancer development might be explained by the interaction between dietary fiber and hormonal processes. we studied the effects of dietary fiber and the effects of a reduced energy intake on the exposure of mammary tissue to both estrogens and progesterone, as well as the blood plasma levels of these steroids and of lh and fsh. adult female fisher rats were fed ad libitum either a low-fiber diet (0.5% dietary fiber based on wheat flour) or a high-fi ...19921329421
changes in myocardial beta-adrenergic receptors during acute rejection of heterotopically transplanted rat evaluate changes of the myocardial beta-adrenergic receptors in acute cardiac graft rejection, the density and binding affinity value of the myocardial beta-adrenergic receptors in heterotopically transplanted rat isografts and allografts were analyzed. hearts from fisher rat donors were transplanted either to the fisher rats (isografts) or to lewis rats (allografts). histologic examination of the allografts showed mild to moderate rejection on the seventh and fourteenth days and showed sever ...19921333553
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