Publications

TitleAbstractYear(sorted ascending)
Filter
PMID
Filter
robert henry fisher smith. 197763707
[numerical procedure for the decomposition of biorhythmic processes into harmonic oscillating components].a numerical procedure for decomposition of time series into inherent periodic nonstochastic components in form of harmonic oscillations will be explained. it is supposed that the rhythmic process is built up by these harmonic oscillating components and by a stochastic component. the procedure is a combination of harmonic analyses for intervals with different numbers of measured values with a significance test elaborated by r.a. fisher for the greatest component in the spectrum. the parameter val ...1977914007
upper lid jerks in the fisher syndrome. 1977872845
syndrome of ophthalmoplegia, ataxia and areflexia.the clinical details and results of some laboratory investigations are described in 4 patients who initially presented with severe external ophthalmoplegia, ataxia and areflexia. in 3 of these patients paresis of the limbs was restricted and minimal as in the syndrome first described by fisher (1956). the fourth patient initially presented with similar symptoms but his illness progressed to a more typical form of acute idiopathic polyneuropathy, confirming fisher's (1956) contention that this sy ...1977616611
ma changes in institutionalized down's syndrome persons: a semi-longitudinal approach.a semi-longitudinal approach was employed in this partial replication of a larger study of ma changes in institutionalized retarded persons (fisher & zeaman, 1970). curves were fitted to ma data for a down's syndrome group and a group of retarded subjects matched on the basis of initial ma and ca. the findings generally replicated those of the earlier study. specifically, the results of a multiple regression/correlation analysis indicated that the two curves were similar in shape, but differed w ...1978147627
rate of polymer formation and entropy production during competitive replication.the rate of increase in the mean polymer formation rate constant during competitive replication by qbeta rna variants (kramer et al., 1974) has been shown to agree statistically with the variance in their formation rate constants. this result demonstrates that fisher's fundamental theorem of natural selection (fisher, 1930) can define time variations in the mean rate of synthesis for a heterogeneous population of replicating polymers. it was also revealed that rna replication, far from equilibri ...1978633382
frequency and cooccurrence of vocal tract dysfunctions in the speech of a large sample of parkinson patients.in this study, the frequency of occurrence of speech and voice symptoms in 200 parkinson patients was defined by two expert listeners from high-fidelity tape recordings of conversational speech samples and readings of the sentence version of the fisher-logemann test of articulation competence. specific phonemes that were misarticulated were catalogued. other vocal-tract dysfunctions, including laryngeal disorders, rate disorders, and hypernasality, were also recorded. cooccurrence of symptoms in ...1978633872
inbreeding effects in a coastal village and other parts of andhra pradesh.a survey was carried out among fisher-women in pallepalam, in nellore district of andhra pradesh, to determine the prevalence and pattern of consanguinity and its effects on fertility, mortality, and morbidity. of the 106 marriages investigated, 54.72% were consanguineous with predominant proportions of first cousin (36.79%) and uncle-niece (13.21%) marriages. the average inbreeding coefficients for autosomal and sex-linked genes were found to be 0.0405 and 0.0448 respectively. the differences b ...1978751385
s-phase fractions of breast carcinomas. relationships to morphology, estrogen and progesterone receptors, and early recurrence.analysis of the s-phase fractions (spf) measured by in vitro thymidine labeling, morphological appearances, and estrogen receptor (er) assays of primary invasive breast carcinomas demonstrated several interrelationships. lobular, mucinous, tubular, and adenocystic carcinomas consistently had low spf and were usually positive for er. the same was true for the carcinomas of no special histologic type [the not otherwise specified (nos) group of e. r. fisher including "infiltrating ductal" and undif ...1978747801
acute ophthalmoplegia, ataxia, and areflexia (fisher syndrome) in childhood. 1978668113
[ophthalmophlegic polyneuritis. a clinical contribution to fisher's syndrome].this paper describes 6 patients with the syndrome of ophthalmoplegic polyneuritis fairly identical to that described by fisher. the most striking symptom of the ophthalmoplegic polyneuritis is the acute ophthalmoplegia, usually total and bilateral, often with sparing of the pupillary reflexes and of the levater palpebrae. the disturbances may simulate a paralysis of gaze or a internuclear palsy. following features may announce this illness: mild harmless infectious disease, sensory deficits, gen ...1978625400
freeze-fracture autoradiography: the in-vacuo coating technique.freeze-fracture autoradiography (ffa) was introduced in 1976 as a new method for electron microscopic autoradiography of diffusible compounds (fisher and branton, rix et al.). with the original technique, the film monolayer was applied to the cold specimen in a cryostat at atmospheric pressure. coating under these conditions did not exclude the risk of artifacts, mainly due to uncontrolled ice contamination of the cold specimen surface. a new method has been developed for coating the frozen spec ...1978738908
corticosteroid therapy of alcoholic hepatitis.fifty-five patients with alcoholic hepatitis were studied in a 28- to 32-day randomized double blind treatment trial comparing prednisolone (40 mg per day) with placebo therapy. of 31 placebo-treated patients, 4 died during the study interval and 2 more died within 5 days of study completion. only 1 of 24 prednisolone-treated patients died during the same interval (fisher exact test; p = 0.10). stepwise discriminant analysis of laboratory factors associated with death revealed independently sign ...1978352788
[fisher's syndrome. peripheral or central origin (author's transl)].the syndrome described by m. fisher in 1956 includes ophtalmoplegia, ataxia, and generalized loss of reflexes. it is classically considered to be of peripheral origin and its relation to guillain and barre's syndrome in its mesencephalic form is debatable. the authors review 5 cases and discuss the question of a probable central origin. they base their opinion on the pathognomonic features of these cases and those in the literature, as well as the results of their oculographic and electromyograp ...1978214838
mathematical theory of group selection: structure of group selection in founder populations determined from convexity of the extinction operator.genetic analysis for group selection is developed for the case of a biallelic locus (a, a) undergoing group selection of founder populations only. by contrast to r. levins"e = e(x) models, extinction now depends on genetics at the propagule stage but acts uniformly on larger populations. biological evidence supports this hypothesis, which also allows mathematical treatment at once simpler and biologically more general than the fokker-planck partial differential equation formalism adopted by levi ...197816592520
[fisher syndrome]. 1978669454
john own fisher davies. 197876163
homicide and community-based psychiatry.the authors studied the records of all persons convicted of homicide or found not guilty by reason of insanity during the uears 1963 through 1975, 6 years before and after the opening of the community-based psychiatric facility, in albany county, new york. using the fisher exact probability test, a statistically significant increase was found for those found not guilty by reason of insanity (p = .041) and those with a history of mental illness found guilty (p = .036). other factors, including ag ...1978722309
selfish genes, evolutionary games, and the adaptiveness of behaviour.the science of sociobiology, which began in principle with the work of fisher and haldane and has more recently been developed by hamilton, maynard smith, trivers, wilson and others, has been the centre of both scientific and political controversy. dr parker discusses the strengths and weaknesses of the approach, and illustrates that behaviour can be adapted in a complex way in conformity with sociobiological theory.1978683325
site of lesion in fisher syndrome. 1978707991
[fluorescence angiography as a basis for successful prophylactic and therapeutic light coagulation for diabetic retinopathy (author's transl)].the fluorescence angiogramme served as a basis for the plan of treatment and as a criterion of treatment success in 192 patients with diabetic retinopathy who underwent xenon-light coagulation between january 1971 and october 1972. in 64 patients this success could be statistically evaluated comparing the untreated partner eye according to the exact fisher-test. the rate of success of light coagulation showed itself to be statistically highly significant (p less than 0.01%) with regard to retina ...1978703143
the descriptive and comparative postcranial osteology of marten (martes americana turton) and fisher (martes pennanti erxleben): the axial skeleton. 1978667756
bioassay of p-anisidine hydrochloride for possible carcinogenicity (cas no. 20265-97-8).a bioassay for possible carcinogenicity of p-anisidine hydrochloride was conducted using fischer 344 rats and b6c3f1 mice. p-anisidine hydrochloride was administered in the feed, at either of two concentrations, to groups of 55 male and 55 female animals of each species. fifty-five animals of each sex and species were placed on test as controls. the high and low dietary concentrations of p-anisidine hydrochloride were, respectively, 0.6 and 0.3 percent for rats and 1.0 and 0.5 percent for mice. ...197812799675
bioassay of sulfallate for possible carcinogenicity (cas no. 95-06-7).a bioassay for possible carcinogenicity of sulfallate was conducted using osborne-mendel rats and b6c3f1 mice. sulfallate was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. twenty mice and 50 rats of each sex were placed on test as controls for the bioassay. the time-weighted average high and low dietary concentrations of sulfallate were, respectively, 410 and 250 ppm for male rats, 404 and 250 ppm for female rats, 1,897 and ...197812799676
bioassay of malathion for possible carcinogenicity.a bioassay of technical-grade malathion for possible carcinogenicity was conducted by administering the test chemical in feed to osborne-mendel rats and b6c3f1 mice. groups of 50 rats of each sex were administered malathion at one of two doses for 80 weeks, then observed for 33 weeks. time-weighted average doses were 4,700 or 8,150 ppm. matched controls consisted of groups of 15 untreated rats of each sex; pooled controls consisted of the matched controls combined with 40 untreated male and 40 u ...197812844184
bioassay of 1,1,2-trichloroethane for possible carcinogenicity.a bioassay of technical-grade 1,1,2-trichloroethane for possible carcinogenicity was conducted using osborne-mendel rats and b6c3f1 mice. 1,1,2-trichloroethane in corn oil was administered by gavage, at either of two dosages, to groups of 50 male and 50 female animals of each species, 5 days a week for a period of 78 weeks, followed by an observation period of up to 35 weeks for rats and up to 13 weeks for mice. the high and low time-weighted average dosages of 1,1,2-trichloroethane were, respec ...197812830223
bioassay of mexacarbate for possible carcinogenicity.a bioassay of technical-grade mexacarbate for possible carcinogenicity was conducted using osborne-mendel rats and b6c3f1 mice. mexacarbate was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. the time-weighted average high and low dietary concentrations of mexacarbate were 418 and 209 ppm for male rats, 678 and 339 ppm for female rats, 654 and 327 ppm for male mice and 135 and 68 ppm for female mice. after a 78-week period of ...197812799715
bioassay of 2-methyl-1-nitroanthraquinone for possible carcinogenicity.a bioassay of 2-methyl-1-nitroanthraquinone for possible carcinogenicity was conducted using fischer 344 rats. 2-methyl-1-nitroanthraquinone was administered in the feed at either of two concentrations to groups of 50 male and 50 female animals. the high and low dietary concentrations used were 0.12 and 0.06 percent, respectively, for the male and female rats. after a 78-week treatment period, observation of the rats continued for an additional 31 weeks. fifty rats of each sex were placed on tes ...197812844179
alpha benzene hexachloride inhibition of aflatoxin b1-induced hepatocellular carcinoma. a preliminary report.alpha benzene hexachloride protected against the development of liver carcinoma in male albino fisher rats ingesting aflatoxin b1.197881137
[effect of microbial and tumor cell adaptation to rubomycin on their uptake of rubomycin and carminomycin].anthracycline antibiotics rubomycin (daunomycin) and carminomycin rapidly accumulated in the bacterial and ascitic tumor cells and their intracellular concentrations significantly exceeded the concentrations in the medium. the strains of staph. aureus and fisher mouse ascitic lymphadenosis l-5178/p resistant to rubomycin preserved sensitivity to carminomycin. the resistance of the bacterial and tumor strains to rubomycin was accompanied by a significant decrease in the accumulation of rubomycin ...1978697342
[effect of normal microflora, age and sex of rats on serum igg2 levels].germfree and conventional rats of fisher inbred strain and mongrel animals were used in this study. igg2 was separated from the pool serum of mongrel rats, and anti-igg2 was obtained by hyperimmunization of rabbits. igg2 content was determined by in the sera of different groups of rats radial immunodiffusion. there was 5.4 times less igg2 in the sera of fisher germfree rats than in conventional fisher animals; its level in female animals was by 10--15% higher than in the male ones. the first hou ...1978698380
metabolic clearance of endogenous and radioiodinated thyroglobulin in rats.the basal concentration and metabolic clearance of radiolabeled and endogenous thyroglobulin (tg) were measured in normal male rats. serum tg concentrations (by ria) in sprague-dawley adult males ranged from 70-680 ng/ml (mean +/- sd, 218 +/- 177). in male fisher rats, basal serum tg concentrations were 32-263 ng/ml. the fractional disappearance rate of endogenously radioiodinated rat tg and of endogenous rat tg after thyroidectomy were both about 8%/h. the mcr of endogenously labeled tg was 2.4 ...1978744090
synthesis of some 11h-indolo[3,2-c][1,8]naphthyridines.the preparation of some 11h-indolo[3,2-c] [1,8]naphthyridines (v), having oxygen functions at positions 3 or 3 and 10 or 3 and 8, as in steroidal active compounds, is described. compounds (v) were obtained using the fisher indole synthesis. the preparation of the parent nucleus: 11h-indolo [3,2-c] [1,8]naphthyridines (v n) is also described. some compounds were subjected to pharmacological screening, but none was found to be significantly active.1978744236
effect of antithymocyte globulin on islet of langerhans transplantation.lewis rats were treated with streptozotocin to induce hyperglycemia and glycosuria (400-600 mg/dl). transplantation of approximately 1,000 dissociated islets obtained from collagenase-treated pancreases from 4 donors will promptly correct induced diabetes. functional survival of islet allografts is related to genetic disparity between donor and recipient strains. in the closely matched fisher-to-lewis combination, islets functioned for a mean of 4.2+/-1 days while in the agb-incompatible wistar/ ...1978106312
age differences in short-term memory and cell loss in the cortex of the rat.studies with human and animal subjects have indicated age declines in short-term memory and cell loss in the cortex. cell loss has been estamated by descriptive nonautomated methods. declines in short-term memory may be related to reduced learning, movtivation, motor capacity, or some combination of these factors. passive-avoidance tests of memory minimize these factors. direct correlational studies on learning and memory in relation to cell loss in the same subject are not feasible in man and t ...1978624457
tolerance to amphetamine's facilitation of self-stimulation responding: anatomical specificity.further work on the phenomenon reported by leith and barrett, wherein tolerance was shown to develop to the well-known d-amphetamine-induced facilitation of self-stimulation, clearly indicates that the development of such tolerance is dependent on the location of the stimulating electrode. thirty-seven fisher or harlan rats were trained to bar press for hypothalamic stimulation (60 hz, ac). following several sessions during which small doses of d-amphetamine were administered to demonstrate faci ...1978638781
survival of normal and magnesium-deficient erythrocytes in rats: effect of magnesium-deficient diet vs. splenectomy.magnesium deficiency in rats causes anemia, the mechanism of which is unknown. the effect of dietary magnesium, splenectomy, and magnesium content of erythrocytes on erythrocyte survival was studied in fisher rats. half of the animals were splenectomized, the remainder sham-splenectomized; each group was subdivided, and some were placed on a magnesium-deficient diet, the rest on a control diet. after 6 weeks, each of the four subgroups was divided, half were given 51cr-labeled red cells from mag ...1978641390
hybridization between different strains of schistosoma intercalatum fisher, 1934 from cameroun and zaïre.the offspring from hybridization experiments between schistosoma intercalatum, cameroun (intermediate host bulinus forskalii) and s. intercalatum, zaïre (intermediate host b. globosus) was investigated. reciprocal crosses between the two forms were performed. f1- and f2-miracidia developed in both parental intermediate hosts. the minimum prepatent period was 24 days at 26 degrees c, an average of the prepatent periods for the two parental strains. the total cercariae production per 100 exposed s ...1978659822
the effect of halothane anaesthesia on liver regeneration.the effects of halothane and diethyl ether on the regenerating liver following 70 per cent hepatectomy were studied in fisher/344 (f) rats. our aim was to discover whether halothane administered repeatedly and over prolonged periods could influence the liver regenerative process or hepatocyte function. we also wished to know if the effects of halothane differed from those of diethyl ether. we found: 1. prolonged halothane or diethyl ether anaesthesia did not inhibit liver mitotic activity, even ...1978667672
peptide mapping characterization of viral proteins generated in a cell-free coupled system for the transcription and translation of influenza virus mrna.in a coupled cell-free system for the transcription and translation of the influenza mrna's, containing detergent-disrupted purified nws influenza virion and a micrococcal nuclease-preincubated rabbit reticulocyte lysate, five unglycosylated viral proteins (ns1, m, np, p1, and p3) were easily produced and isolated. their identification was based on the electrophoretic separation of peptide fragments resulting from their partial digestion with proteases of restricted specificity (d.w. cleveland, ...1978671587
studies on schistosoma intercalatum fisher, 1934 and its intermediate snail host in the kisangani area, zaire. 1978677950
[change in the concentration and non-homogeneity of rna and sh-group distribution in pyramidal neurons of cat cerebral cortex following epileptiform activity].concentrations of rna and sh-groups were determined in pyramidal neurons of somatosensory cortex of the intact cats and after epileptiform activity induced by electrical stimulation. the mean concentrations of rna and of sh-groups and the fisher information exponent were calculated in different zones of the pyramidal neuron cytoplasm zone of the apical dendrite and that of the axon departure. with epileptiform activity, rna and sh-group contents and the information exponent were seen decreased. ...1978695011
experimental infection with schistosoma intercalatum (fisher, 1934) in the chimpanzee (pan troglodytes) and the gibbon (hylobates lar).two young chimpanzees (pan troglodytes) and two adult gibbons (hylobates lar), each exposed to 1,000 cercariae of schistosoma intercalatum (cameroon), were examined at 79 and 82 wk and 61 and 69 wk, respectively, post-infection. based upon worn returns and tissue egg deposits, these primates can be employed as hosts for experimental schistosomiasis intercalata. however, no histopathology was detected in the urogenital system.1978677377
the capacity of histocompatibility antigens solubilized in hypertonic salt solution to induce allograft tolerance in rats.treatment of fisher rats (agb 1,26,28) with a soluble extract of histocompatibility antigens (sae) prepared from the liver of donor august rats (agb 5, 28, 31) associated with a few injections of anti-lymphocyte serum (als) provoked a specific prolongation of the median survival time of skin grafts from 27.6 +/- 11.4 days in als-treated controls to 55.1 +/- 8.8 days (p less than 0.01). the sae was obtained from liver homogenates by hypertonic kcl (3m) extraction. further purification by chromato ...1978350127
assignment of nadh-cytochrome b5 reductase (dia1 locus) to human chromosome 22.nadh-cytochrome b5 reductase (dia1, ec. 1.6.2.2) from human fibroblasts and from chinese hamster cells, both identified by immunologic studies, were clearly distinguished after polyacrylamide gel isoelectro-focusing followed by staining for nadh diaphorase activity. in thirteen independent man-hamster hybrids, the human enzyme dia1 presented a positive correlation with the human chromosome g22. eight hybrids were dia1(+) g22(+) and five hybrids were dia1(-) g22(-). these data agree with the rece ...1978669708
on factors possibly restricting the distribution of schistosoma intercalatum fisher, 1934.two hypotheses have been postulated explaining the limited distribution of schistosoma intercalatum. the first hypothesis is correlated with physical factors and behaviour of cercariae. histochemical and ultrastructural studies have shown that in response to increased temperature change the cercariae of s. intercalatum form aggregates, unlike other schistosome cercariae of man, which are non-infective to the definitive host. the aggregates are formed by the release of the adhesive post-acetabula ...1978695826
growth control in simian virus 40-transformed rat cells: temperature-independent expression of the transformed phenotype in tsa transformants derived by agar selection.fisher rat fibroblasts (fr 3t3), transformed with the tsa30 mutant of simian virus 40 and selected by colony formation in soft agar, maintained the transformed phenotype at high temperature, whereas most transformants isolated from foci were found to undergo a phenotypic reversion toward the normal state in their saturation density, ability to grow in soft agar, and rate of 2-deoxyglucose transport. the temperature-independent phenotype observed in agar-selected transformants was not due to a re ...1978212596
impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats.a series of neurophysiological experiments was performed on the schaffercommissural system of the hippocampus of aged and young anesthetized fischer rats. the aged fisher rats were previously found to exhibit retention performance deficits. no obvious differences were found between aged and young animals in amplitude, latency, stimulation threshold, or wave forms of typical synaptic responses when these were elicited by control (0.3 hz) stimulation pulses. further, the temporal curves of facilit ...1978208716
histology and ultrastructure of the r-3327 c-f transplantable prostate tumor of cophenhagen-fisher rats.the r-3327 c-f tumor is an adenocarcinoma of the prostate maintained by serial transplantation in male copenhagen-fisher hybrid rats. the tumor is histologically different from other tumor sublines derived from the original r-3327 tumor discovered in 1961 in an aged copenhagen rat. light and electron microscopy have shown that the r-3327 c-f tumor contains a well organized glandular epithelium with myoepithelial cells and a continuous basement membrane, although epithelial cells were much less d ...1978711418
schistosoma intercalatum fisher, 1934 (cameroon) infection in the patas monkey (erythrocebus patas schreber, 1775). 1978415994
development of hyperlipidemia associated with increased lipolytic response of isolated adipose tissue cells following prolonged stimulation by an ectopic pituitary tumor.implantation of mtt-f4 tumor, a mammotropic tumor that secretes large quantities of acth, gh and prolactin, into male fisher rats induced the development of hyperlipidemia. free fatty acid, triglyceride and cholesterol levels in the plasma were significantly increased at 31 days after tumor implantation. blood glucose and glycerol levels remained normal, while uric acid concentration in the blood was significantly decreased. the lipolytic response of isolated adipose tissue cells to acth was sig ...1978217811
preliminary observation on the immunology of nerve allograft rejection.a preliminary experiment was devised to delineate the specificity of nerve allograft rejection. skin grafts were performed between inbred strains of fisher, agb1, and buffalo, agb6, rats to determine the time required for a first set rejection, which occurred at day 9. skin grafts also were performed two weeks after orthotopic placement of whole nerve or fascicular grafts. the rats that had previously been exposed to whole nerve showed skin graft rejection at six days, while those exposed to ner ...1978337545
[role of normal microflora in the treatment of vibrio carrier state in rat gnotobionts].materials on the study of interactions between vibrio cholera el tor and some indigenous bacteria of human intestinal tract, which proved to be active antagonists in vitro, are presented in this work. experiments were conducted on gnotobiotic rats (fisher), using various combinations and variants of the order of the microorganism administration; there were revealed no antagonistic relations between virbrio cholerae el tor and escherichia coli m-17, lactobacillus fermenti, lactobacillus plantarum ...1978352437
hybridization and heat tolerance in rats.buffalo and fisher inbred rats and their f1--f4 hybrids were exposed to heat, 96 degrees f and 30% humidity, at 35 days of age. fisher rats which are of lighter weight survive significantly longer than buffalo rats which are heavier. body weight was significantly depressed in all hybrids. only in f2 hybrids was heat tolerance similar to that of the fisher inbreds. in all other hybrids, it was lower. no heterosis was found under the conditions used.1979525249
a comparison of the characteristics of two strains of schistosoma intercalatum fisher, 1934 in mice.schistosoma intercalatum from cameroon and zaire each have their specific snail intermediate host. hybridization experiments between s. intercalatum from cameroon and zaire have resulted in viable miracidia for only two generations. if the two strains are of the same species, cross breeding should be possible for several generations. this paper presents a comparison of the characteristics of the two strains of s. intercalatum in experimental infections in mice. worm return, male-female worm rati ...1979541492
effects of carbon disulfide on motor function and responsiveness to d-amphetamine in rats.male, albino rats of the fisher strain were exposed to 2 mg carbon disulfide/l of air for 4 hours per day, 5 days per week for 6 weeks. neurobehavioral effects were not observed after 3 weeks of dosing, but hindlimb extensor responses and performance on the inclined screen (motor coordination) were impaired after 6 weeks of exposure. forelimb grip strength and exploratory locomotor activity were not affected. three weeks after cessation of dosing, recovery of function was observed. rats exposed ...1979551304
adipocyte cholesterol storage: effect of experimental hypercholesterolemia in the rat.in order to more clearly define the influence of adipocyte size and plasma cholesterol on adipose tissue cholesterol storage, hypercholesterolemia was induced in male fisher rats at a time when body weight and adipocyte size become fixed. in one experiment (experiment 1), increasing amounts (0, 0.05, 0.5 and 5.0%) of dietary cholesterol were added to a fat-free, purified diet (sucrose-casein-cellulose) fed to 1 year old virgin males. in experiment 2, retired breeder rats were fed 0 or 5% cholest ...1979512709
loss of synapses in the cerebellar cortex of the senescent rat.numbers of synapses were compared in the cerebellar cortex of adult (12 months of age) and senescent (25 months of age) male rats of the fisher-344 strain. the total number of axodendritic synapses was found to be 24% lower in the senescent rats as compared with adults. a differential analysis of synapses involving dendritic shafts and spines showed no significant change in numbers of synapses involving shafts, but a highly sigificant 33% decrease in numbers involving spines in senescent rats. t ...1979512301
hyperlipoproteinemia induced by a transplantable pituitary tumor in the rat.the mtt-f4 tumor, a transplantable pituitary tumor of rats, induces significant hyperlipidemia in male fisher 344 rats. the increasive hypercholesterolemia was accompanied by hypertriglyceridemia only in the first month of tumor implantation. clofibrate feeding inhibited the development of hypercholesterolemia and maintained normal serum triglyceride levels. in contrast to the changes in lipoprotein cholesterol distribution and profile found in experimental hyperlipidemia induced by high fat and ...1979465111
[action of cyclophosphane on the formation of hemagglutinins and of nonspecific immunoglobulins in a microbe-free state].a total of 39 germ-free and 28 conventional germ-free fisher rats were used to study cyclophosphamide-induced specific (hemagglutinins) and nonspecific (igg2) immunosuppression. most pronounced effect of the drug was observed in germ-free animals. 180 mg/kg of cyclophosphamide completely suppressed hemagglutinin formation for at least 8 weeks.1979442887
the relative capacity of corneal, heart, kidney and skin cells to stimulate allogeneic lymphocytes.in stimultaneous experiments, the ability of inbred wistar-furth rat corneal cells to stimulate inbred fisher rat lymphocytes in mixed culture was compared with the stimulatory capacity of the same number of wistar-furth skin, kidney, heart and lymphocyte cells. the tissue cells were dissociated and after inhibition by mitomycin c cultured with an equal number of allogeneic spleen lymphocytes for 5 days. in all of these mixed cell cultures, the allogeneic lymphocytic response was mainly to the m ...1979437826
experimental chronic serum sickness in rats. a model of immune complex glomerulonephritis and systemic immune complex deposition.this article describes a method of immunization that produces chronic serum sickness in rats within a relatively short time. fisher rats, which were immunized subcutaneously three times with bovine serum albumin (bsa) in adjuvant, responded with high titers of antibodies to bsa. 2 weeks after the third subcutaneous immunization, daily increasing amounts of bsa were injected either intraperitoneally or intravenously. when an intravenous dose of 2mg of bsa was reached, the rats were given daily in ...1979156700
experimental hyperlipidemia in rats.implantation of mtt-f4 tumor, a mammotropic tumor that secretes large quantities of acth, gh and prolactin, into male fisher rats induced the development of hyperlipidemia. free fatty acid, triglyceride and cholesterol levels in the plasma were significantly increased at 31 days after tumor implantation. blood glucose and glycerol levels remained normal, while uric acid concentration in the blood was significantly decreased. the concentrations of the serum lipoproteins were significantly increas ...1979224751
selective lymphoid irradiation. i. an approach to transplantation.the kinetics, distribution, and radiobiologic effects of palladium (pd)-109-hematoporphyrin were determined in the rat. in addition, we studied the effect on rat heart allograft survival of pd-109-hematoporphyrin, with and without antilymphocyte serum (als). a single sublethal dose of pd-109-hematoporphyrin (up to 36 muci/kg) resulted in the following: predominant concentration in lymphoid tissue and proximal bone marrow, complete central and proximal bone marrow ablation with preservation of di ...1979380034
specific neutralization of defective spleen focus-forming virus in friend virus complex by rat antiserum.the spleen focus-forming virus (sffv), a rapidly transforming, replication-defective virus in friend virus (fv) complex that is readily neutralized by antisera directed against its helper virus, was examined for the presence of sffv-specific antigens. antisera prepared in fisher rats against an sffv-infected fisher rat embryo fibroblast line (sffv-fre) neutralized sffv effectively, but not friend-associated murine leukemia virus (f-mulv) whether the latter was tested alone or was mixed with sffv ...197990172
the mechanism of peripherally evoked responses in retinal ganglion cells.1. responses to stimulation of retinal regions remote from the classical receptive field were recorded from optic tract fibres in lightly anaesthetized cats. 2. x- and y-cells gave reliably different responses to the sudden reversal of the phase of a high contrast grating that fell on the retina more than 15 deg from the centre of the receptive field. 3. the mechanism that generates these responses ('shift effect' or 'periphery effect') in y-cells is insensitive to the spatial phase of the stimu ...1979458660
a method for the routine assessment of fore- and hindlimb grip strength of rats and mice.a technique to measure the fore-and hindlimb grip strength of rats (adult and preweanling) and mice is described. the procedure utilizes inexpensive equipment, is rapid and efficient, and provides continuous level data. as a means of validating the sensitivity of the test, the effects of phenobarbital and chlordiazepoxide on the grip strength of adult fisher strain and sprague-dawley derived adult rats were investigated. dose-related decreases in fore- and hindlimb grip scores were observed in b ...1979551317
the influence of diazepam administration in rats bearing the r3230ac mammary carcinoma.the growth of the r3230ac mammary carcinoma was studied in female fisher 344 rats that were treated with diazepam. diazepam at 250 micrograms/animal/day (2.5 mg/kg body weight) and 500 micrograms/day was administered for 4 weeks, starting 2 days before subcutaneous transplantation of uniform pieces of the tumour. tumour size was significantly increased in the group receiving 250 micrograms but was below the levels observed in the saline treated controls in those given 500 micrograms diazepam. pl ...1979552103
age pigments, cell loss and hippocampal function.the specific aims of this study were to perform direct correlational analyses of age differences in learning, short-term memory and arousal in relation to cell loss and lipofuscin increase in the hippocampus ca1 zone and in visual area 17 of the fisher 344 rat. the following tentative conclusions can be made from the results presented in this study: (1) significant age differences in 2 and 6 hour passive-avoidance retention or memory between mature and old rats were related to non-significant ag ...1979571502
helminth parasites of fisher martes pennanti (erxleben) from manitoba, canada.seven species of helminths were recovered during a survey of 162 fisher (martes pennanti) from four areas of manitoba: baylisascaris devosi in 52 fisher; taenia sibirica in 25; physaloptera sp. in nine; alaria mustelae in two; metorchis conjunctus in one; trichinella spiralis in one of 81; molineus sp. in one. b. devosi was the most prevalent parasite and differences in its geographical distribution were possibly related to population density of fisher. the prevalence of other parasites did not ...1979574167
bioassay of a solution of b-nitrostyrene and styrene for possible carcinogenicity.a bioassay of a solution of 30 percent b-nitrostyrene and 70 percent styrene for possible carcinogenicity was conducted using fischer 344 rats and b6c3f1 mice. the solution of the two test materials in corn oil was administered by gavage, at either of two dosages, to groups of 50 male and 50 female animals of each species. the high and low dosages utilized in the study were, respectively, 300 and 150 mg/kg for male rats; 150 and 75 mg/kg for female rats; and 175 and 87.5 mg/kg for mice of both s ...197912799693
bioassay of 2-(chloromethyl)pyridine hydrochloride for possible carcinogenicity (cas no. 6959-47-3).2-(chloromethyl)pyridine hydrochloride, an aromatic heterocycle used in a variety of syntheses, was selected for bioassay by the national cancer institute because of the structural similarity of this compound to 2-(a,b-dichloroethyl)-pyridine hydrochloride, a carcinogen in rats, mice, syrian hamsters, and mongolian gerbils. a bioassay for the possible carcinogenicity of 2-(chloromethyl)pyridine hydrochloride was conducted using fischer 344 rats and b6c3f1 mice. 2-(chloromethyl)pyridine hydrochlo ...197912778175
bioassay of michler's ketone for possible carcinogenicity (cas no. 90-94-8).michler's ketone, a dye intermediate and derivative of dimethylaniline, was selected for bioassay by the national cancer institute because of the elevated incidence of bladder cancer noted among dye manufacturing industry workers. a bioassay for the possible carcinogenicity of technical-grade michler's ketone was conducted using fischer 344 rats and b6c3f1 mice. michler's ketone was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each spec ...197912778196
bioassay of 5-chloro-o-toluidine for possible carcinogenicity (cas no. 95-79-4).5-chloro-o-toluidine, an aromatic amine and dye intermediate, was selected for bioassay by the national cancer institute because of the high incidence of bladder cancer observed among dye manufacturing industry workers. a bioassay for the possible carcinogenicity of 5-chloro-o-toluidine was conducted using fisher 344 rats and b6c3f1 mice. 5-chloro-o-toluidine was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. twenty animals ...197912778191
bioassay of p-quinone dioxime for possible carcinogenicity (cas no. 105-11-3).p-quinone dioxime, a rubber vulcanization accelerator, was selected for bioassay by the national cancer institute because of a lack of adequate carcinogenicity data. a bioassay for the possible carcinogenicity of p-quinone dioxime was conducted using fischer 344 rats and b6c3f1 mice. p-quinone dioxime was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. twenty animals of each sex and species were placed on test as controls, wi ...197912778198
bioassay of 2,5-dithiobiurea for possible carcinogenicity.a bioassay of 2,5-dithiobiurea for possible carcinogenicity was conducted using fischer 344 rats and b6c3f1 mice. 2,5-dithiobiurea was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species, with the exception of high dose male rats, of which there were only 49. the dietary concentrations used in the chronic bioassay were 0.6 percent for the low dose rats and 1.2 percent for the high dose rats. the dietary concentrations used for low ...197912799660
bioassay of styrene for possible carcinogenicity (cas no.100-42-5).styrene, a widely used intermediate in the manufacture of plastics, elastomers, and resins, was selected for bioassay by the national cancer institute because of the widespread use of this compound and a lack of adequate carcinogenicity data. a bioassay for the possible carcinogenicity of styrene was conducted using fischer 344 rats and b6c3f1 mice. styrene was administered by gavage to groups of 50 male and 50 female animals of each species. forty rats of each sex and twenty mice of each sex we ...197912778193
bioassay of 4,4'-methylenebis-(n,n-dimethyl)benzeneamine for possible carcinogenicity (cas no. 101-61-1).4,4'-methylenebis(n,n-dimethyl)benzeneamine, a bicyclic aromatic amine and an intermediate in dye manufacture, was selected for bioassay by the national cancer institute because of a high incidence of bladder cancer observed among dye manufacturing industry workers. a bioassay for the possible carcinogenicity of 4,4'-methylenebis-(n,n-dimethyl)benzeneamine was conducted using fisher 344 rats and b6c3f1 mice. 4,4'-methylenebis-(n,n-dimethyl)benzeneamine was administered in the feed, at either of ...197912778192
bioassay of dibutyltin diacetate for possible carcinogenicity (cas no. 1067-33-0).dibutyltin diacetate, a widely used catalyst for polymerization reactions, was selected for bioassay by the national cancer institute in an effort to screen a number of organo-metallic compounds for carcinogenicity. a bioassay for the possible carcinogenicity of dibutyltin diacetate was conducted using fischer 344 rats and b6c3f1 mice. dibutyltin diacetate was administered in the feed, at either of two concentrations, to groups of 50 male and female animals of each species. twenty animals of eac ...197912778195
bioassay of p-nitrosodiphenylamine for possible carcinogenicity (cas no. 156-10-5).p-nitrosodiphenylamine is used to accelerate the vulcanization of rubber. it is also used as an intermediate in the manufacture of dyes and pharmaceutical compounds and as an inhibitor of polymerization during the production of vinyl monomers such as styrene. a bioassay for the possible carcinogenicity of p-nitrosodiphenylamine was conducted using fisher 344 rats and b6c3f1 mice. p-nitrosodiphenylamine was administered in the feed, at either of two concentrations, to groups of 50 male and female ...197912778189
bioassay of p-chloroaniline for possible carcinogenicity (cas no. 106-47-8).p-chloroaniline, a dye and chemical intermediate, was selected for bioassay by the national cancer institute because of the high incidence of bladder cancer observed among dye manufacturing industry workers. a bioassay for the possible carcinogenicity of p-chloroaniline was conducted using fisher 344 rats and b6c3f1 mice. p-chloroaniline was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. twenty animals of each sex and specie ...197912778190
bioassay of carbromal for possible carcinogenicity.a bioassay for the possible carcinogenicity of carbromal was conducted using fischer 344 rats and b6c3f1 mice. carbromal was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species with the exception of 49 low dose male mice and high dose female mice. twenty animals of each sex and species were placed on test as controls. the high and low dietary concentrations of carbromal were, respectively, 2,500 and 1,250 ppm for rats and 2,500 an ...197912799690
bioassay of 2-nitro-p-phenylenediamine for possible carcinogenicity.a bioassay for the possible carcinogenicity of 2-nitro-p-phenylenediamine was conducted using fischer 344 rats and b6c3f1 mice. 2-nitro-p-phenylenediamine was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. twenty animals of each sex and species were placed on test as controls. the high and low dietary concentrations of 2-nitro-p-phenylenediamine were, respectively, 1,100 and 550 ppm for male rats, 2,200 and 1,100 ppm for fem ...197912799694
life and work of ronald fisher. 197917731682
relationship between aminoglycoside-induced nephrotoxicity and auditory toxicity.we have reviewed our data from 391 patients entered into three prospective, double-blind studies of aminoglycosides and evaluated 127 cases to determine whether aminoglycoside-induced auditory toxicity and nephrotoxicity are independent events. the cases selected for evaluation included all patients treated for greater than 3 days (mean, 7.7 days) who had serial creatinine determinations and were able to cooperate with serial bedside audiograms (250 to 8,000 hz). patients received either gentami ...1979475363
effect of ammonia on the glutamate dehydrogenase catalyzed oxidative deamination of l-glutamate. the steady state.ammonia is known to inhibit the steady-state rate of oxidation of l-glutamate catalyzed by glutamate dehydrogenase. we reported previously [brown, a., colen, a. h., & fisher, h. f. (1978) biochemistry 17, 2031] kinetic evidence supporting the formation in the initial rapid phase of a complex which is composed of enzyme, reduced coenzyme, alpha-ketoglutarate, and ammonia. we show here that the effects of ammonia on the steady-state reaction can be correlated with transient-state kinetic effects r ...1979518877
fisher's reticulate mating system for immigration into an improved stock.a reticulate mating system is described which was designed by the late r.a. fisher to permit the introduction of new genetic variability into an improved stock by immigration. analysis of part of a long-term experiment to alter the degree of dominance of the mutant sd in mice using the system demonstrates a rapid response. its applicability to stocks of animals of economic value is considered.197924306777
a comparison of coulter zbi and fisher autocytometer ii hematological values in 28 mammalian species at the metropolitan toronto zoo.one hundred and thirty-three blood samples from twenty-eight mammalian, nondomestic species were analyzed using both the coulter zbi and fisher autocytometer ii. the wbc, rbc and hb values for each species from both machines, were compared. the study indicated that for 27 species there was no significant difference (p > 0.05) between machines for the wbc. twenty-one species showed no significant difference (p > 0.05) in the rbc results. only one species exhibited a significant difference (p > 0. ...197915314778
towards a genetic theory for the evolution of the sex ratio.a genetical model is formulated in which the sex ratio in broods and the relative size of broods are determined by the genotype at an autosomal locus. the results also apply to the case in which the sex-ratio locus is sex linked and expressed in the homogametic sex and to the case in which the locus is expressed in the diploid sex of a haplodiploid organism. fisher (1930) argued that the sex ratio evolves under natural selection to a value such that parental expenditure is equalized between the ...197917248977
review of the methods of quantification.in order to analyze qualitative observations, methods of quantification or optimal scaling have been proposed by fisher, guttman, and hayashi. according to these methods, scores are assigned optimally in some objective and operational sense to the qualitative categories. the present paper mainly reviews hayashi's four methods of quantification from the mathematical point of view. they are widely used, especially in japan, in various fields such as social and marketing surveys, psychological rese ...1979540585
body awareness and personality.the relation between personality characteristics and body awareness, defined as the attention paid to different body zones and measured by means of the fisher body focus questionnaire, is examined in two ways in groups of medical and dental students: (1) our results replicate fairly well the relation, reported by fisher, between back and head awareness and anal characteristics. (2) exploration of the relations between body awareness and descriptive personality characteristics (neuroticism, extra ...1979550170
[dissociated ophthalmoplegia of abduction: so-called posterior internuclear ophthalmoplegia in fisher's syndrome].the anterior internuclear ophthalmoplegia, a dissociated ophthalmoplegia of adduction secondary to an ipsilateral supranuclear paresis of the internal rectus, represents a well-know clinical picture. the dissociated ophthalmoplegia of abduction, however, sometimes referred to as posterior internuclear ophthalmoplegia, is debated. such an oculomotor disturbance emerging from an ophthalmoplegic polyneuropathy (fisher syndrome) is presented and illustrated by oculographic tracings. a secondary find ...1979530553
[surgical treatment of the middle cerebral artery aneurysm--from the experiences of 174 cases (author's transl)].174 cases of middle cerebral artery aneurysm submitted to surgical operations without using microscope were reviewed. at operation, the head is set on the neutral and slightly chin up position, not turned to any directions. small craniotomy, which is about half as much as the ordinary unifrontal craniotomy, is performed. the merit of our method is as follows; the m1 portion (fisher) of the middle cerebral artery runs horizontally, so that we can keep the parent artery during the operation, and o ...1979418949
[m. fisher syndrome after antitetanic serotherapy]. 1979503815
estimation of some population parameters of drosophila limbata v. roser in a greenhouse.size and survival rate of a population of drosophila limbata in a cucumber greenhouse in the vicinity of groningen, the netherlands, were estimated twice in the summer of 1975 by mark-release-recapture experiments, using the fisher-ford model. the second time, an independent check was carried out by directly estimating the number of emergences. at the end of june, estimated population size was about 13,600, with a survival rate per day of 53.4%, at the end of july population size was estimated a ...197928308858
ouabain on active transepithelial sodium transport in frog skin: studies with microelectrodes.studies were done with isolated frog skin to determine the effects of 10(-4) m ouabain on the electrophysiological parameters of outer and inner barriers of the na-transporting cells. microelectrodes were used to impale the skins from the outer surface to determine the intracellular voltages (vsco) under conditions of short-circuiting and under conditions where a voltage clamp was used to vary the transepithelial voltage, vt. from this, the electrical resistances of outer (rfo) and inner (ri) ba ...1979314494
apolipoprotein b: its role in the control of fibroblast cholesterol biosynthesis and in the regulation of its own binding to cellular receptors.apolipoprotein b transports cholesterol in plasma as low density lipoprotein (ldl) and targets its delivery to cells by binding to a specific plasma membrane receptor. the cellular consequences of apob binding to its receptor were investigated to determine whether it suppresses cholesterol biosynthesis and reduces the number of cellular receptors for the apoprotein. upon preincubation of fibroblasts with lipoprotein-deficient medium alone or supplemented with either ldl or apob complexed to bsa ...1979226637
a double-blind pediatric evaluation of levamisole in the prevention of recurrent upper respiratory tract infections.levamisole was tested double-blind in 106 children with recurrent upper respiratory tract infections. they received either levamisole (n = 53) or placebo (n = 53) 0.5 ml/kg bodyweight b.i.d. for two consecutive days each week for six months. a control examination was performed every two months. both groups were compared by means of the fisher-test and the mann-whitney u-test (two-tailed probability each). improvement was observed more frequently in the levamisole group with regard to the number ...1979477676
[bone marrow lymphoid follicles in myelofibrosis compared with chronic myelogenous leukaemia (author's transl)].the trephine bone marrow biopsies of 51 patients with myeloproliferative syndromes were revised searching for lymphoid follicles and lymphoplasmocytosis: 18 of these had idiopathic myelofibrosis and 33 chronic myelogenous leukaemia. six of the 18 biopsies on patients with myelofibrosis showed lymphoid follicles but only one of the 33 with chronic meylogenous leukaemia did (p = 0.01, fisher exact test). in addition, four of the six myelofibrosis having follicles had two or more of them. when the ...1979296376
symposium on cerebrovascular disease in honor of c. miller fisher. 19807348969
Displaying items 201 - 300 of 17150