Publications

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prognostic factors in the treatment of squamous cell carcinoma of the larynx: partial surgery x radical surgery.the present study aimed at assessing the other sites as the carcinoma spreads, as well as therapeutic results, in larynx preservation and patient survival.201718278228
predictors of persistent or recurrent disease after loop electrosurgical excision procedure.follow-up recommendations after an excisional procedure vary depending on whether or not there is a positive ectocervical or endocervical margin or endocervical curettage (ecc). the purpose of this study was to evaluate the importance of these findings in predicting recurrent/persistent (r/p) disease in a sample of human immunodeficiency virus (hiv)-seropositive and -negative patients.201727824789
characteristics of an outpatient chronic hepatitis b virus infection cohort.to characterize a chronic hepatitis b cohort based on initial and follow-up clinical evaluations.201726154539
chlamydia trachomatis and hpv co-infections in hiv negative men from a multi-ethnic area of northern italy at high prevalence of cervical malignancies.chlamydia trachomatis and hpv coinfections in the male population are often a disregarded issue. we performed a study to evaluate the prevalence of such infections in heterosexual hiv negative men from a northern italy multi-ethnic area at high prevalence for cervical malignancies. urethral swabs (us) or first-voided urine were evaluated retrospectively from 1317 patients attending sexually transmitted infections (sti) clinic and from 3388 outpatients attending private clinics. informations abou ...201728316071
periodontal pathogenic bacteria and ammp-8 findings depending on periodontal conditions of patients before and after liver transplantation.the aim of this single-center cross-sectional study was to detect the prevalence of selected periodontal pathogenic bacteria and active matrix metalloproteinase-8 (ammp-8) level in patients before (preltx) and after liver transplantation (postltx).201727074844
effect of probiotic on innate inflammatory response and viral shedding in experimental rhinovirus infection - a randomised controlled trial.ingestion of probiotics appears to have modest effects on the incidence of viral respiratory infection. the mechanism of these effects is not clear; however, there is evidence from animal models that the probiotic may have an effect on innate immune responses to pathogens. the purpose of this randomised, placebo-controlled study was to determine the effect of administration of bifidobacterium animalis subspecies lactis bl-04 on innate and adaptive host responses to experimental rhinovirus challe ...201728343401
guillain-barré syndrome.guillain-barré syndrome is an acute inflammatory immune-mediated polyradiculoneuropathy presenting typically with tingling, progressive weakness, and pain. variants and formes frustes may complicate recognition. the best known variant is the sensory ataxic form of miller fisher syndrome, which also affects the oculomotor nerves and the brain stem. divergent pathologic mechanisms lead to demyelinating, axonal, or mixed demyelinating-axonal damage. in the demyelinating form, yet to be identified a ...201728259232
guillain barré syndrome is induced in non-obese diabetic (nod) mice following campylobacter jejuni infection and is exacerbated by antibiotics.campylobacter jejuni is a leading cause of bacterial gastroenteritis linked to several serious autoimmune sequelae such as the peripheral neuropathies guillain barré syndrome (gbs) and miller fisher syndrome (mfs). we hypothesized that gbs and mfs can result in nod wild type (wt) mice or their congenic interleukin (il)-10 or b7-2 knockouts secondary to c. jejuni infection. mice were gavaged orally with c. jejuni strains hb93-13 and 260.94 from patients with gbs or cf93-6 from a patient with mfs ...201727939129
acute disseminated encephalomyelitis following campylobacter jejuni gastroenteritis: case report and review of the literature.we describe a case of a 25-year-old male with a diagnosis of acute disseminated encephalomyelitis (adem) following infection with campylobacter jejuni, which is implicated in various human pathologies regarding the central nervous system (cns) with acute course like guillain-barré syndrome (gbs), miller-fisher syndrome (mfs), bickerstaff's brainstem encephalitis (bee), acute transverse myelitis (atm) as well as adem. these conditions are caused by cross-reactivity between campylobacter's epitope ...201727888275
factors associated with intramammary infection in dairy cows caused by coagulase-negative staphylococci, staphylococcus aureus, streptococcus uberis, streptococcus dysgalactiae, corynebacterium bovis, or escherichia coli.the aim of this study was to determine risk factors for bovine intramammary infection (imi) associated with the most common bacterial species in finland. large databases of the finnish milk-recording system and results of microbiological analyses of mastitic milk samples from valio ltd. (helsinki, finland) were analyzed. the study group comprised 29,969 cows with imi from 4,173 dairy herds. a cow with a quarter milk sample in which dna of target species was detected in the pathoproof mastitis pc ...201728341052
finite-size effects on bacterial population expansion under controlled flow conditions.the expansion of biological species in natural environments is usually described as the combined effect of individual spatial dispersal and growth. in the case of aquatic ecosystems flow transport can also be extremely relevant as an extra, advection induced, dispersal factor. we designed and assembled a dedicated microfluidic device to control and quantify the expansion of populations of e. coli bacteria under both co-flowing and counter-flowing conditions, measuring the front speed at varying ...201728262769
incidence of fever in labor and risk of neonatal sepsis.the current recommendation regarding the management of a term newborn delivered of a mother with an intrapartum fever or a diagnosis of clinical chorioamnionitis is that the neonate should have baseline laboratory work drawn along with blood cultures and be universally treated with antibiotics until culture results return. these guidelines report that the rate of intrapartum fever is about 3%; however, a few large studies suggest that the rate is higher at about 7%.201728216060
homeopathic medicine cantharis modulates uropathogenic e. coli (upec)-induced cystitis in susceptible mice.this is a random blinded placebo controlled murine experimental model to study the effects of cantharis 6 ch, a homeopathic medicine, on e coli-induced cystitis.201728142108
oral therapy, microbiological findings, and comorbidity influence the outcome of prosthetic joint infections undergoing 2-stage exchange.the aim of the present study was to investigate potential predictive factors of an unfavorable outcome in patients with prosthetic joint infection (pji) undergoing 2-stage exchange.201728372916
staphylococcus aureus nasal carriage in health care workers: first report from a major public hospital in argentina.staphylococcus aureus causes numerous mild to severe infections in humans, both in health facilities and in the community. patients and health care workers (hcws) may disseminate strains during regular medical examinations or hospitalization. the aim of this study was to determine the nasal carriage rate of methicillin-susceptible and methicillin-resistant s. aureus among health care workers at hospital provincial del centenario, a public general hospital in rosario, argentina. a transversal stu ...201728343857
intra-articular vancomycin powder eliminates methicillin-resistant s. aureus in a rat model of a contaminated intra-articular implant.periprosthetic joint infection following hip and knee arthroplasty leads to poor outcomes and exorbitant costs. topical vancomycin powder has been shown to decrease infection in many procedures such as spine surgery. the role of vancomycin powder in the setting of total joint arthroplasty remains undefined. our aim was to evaluate the efficacy of intra-articular vancomycin powder in preventing infection in a rat model of a contaminated intra-articular implant.201728145954
impact of chlorhexidine bathing on methicillin-resistant staphylococcus aureus incidence in an endemic chronic care setting: a randomized controlled trial.we postulated that bathing with 2% chlorhexidine-impregnated antiseptic washcloths could reduce methicillin-resistant staphylococcus aureus (mrsa) incidence among chronic care patients compared with nonantiseptic bathing. a total of 122 patients on 3 hospital units were enrolled in a 12-month, cluster-randomized, open-label, controlled trial, with 8 patients becoming mrsa positive. the 2% chlorhexidine-impregnated antiseptic washcloths reduced incidence by 71% (0.1 vs 0.44 cases per 1,000 patien ...201727839752
institutional and seasonal variations in the incidence and causative organisms for posttraumatic infection following open fractures.the current literature focuses on wound severity, time to debridement, and antibiotic administration with respect to risk of infection after open fracture. the purpose of this analysis was to determine if either the incidence of posttraumatic infection or causative organism varies with treating institution or the season in which the open fracture occurred.201727755339
high seroprevalence of toxoplasma gondii antibody in hiv/aids individuals from north of iran.toxoplasmosis in immunocompetent people is generally asymptomatic but in immunocompromised patients including hiv/aids, cancer patients, and organ transplant recipients, etc. it can lead to serious pathological problems. the objective of current study was to determine the seroprevalence of t. gondii igg and igm antibodies in hiv/aids patients using elisa technique in mazandaran province, northern iran.201726811725
application of optimized large surface area date stone (phoenix dactylifera ) activated carbon for rhodamin b removal from aqueous solution: box-behnken design approach.box-behnken model of response surface methodology was used to study the effect of adsorption process parameters for rhodamine b (rhb) removal from aqueous solution through optimized large surface area date stone activated carbon. the set experiments with three input parameters such as time (10-600min), adsorbent dosage (0.5-10g/l) and temperature (25-50°c) were considered for statistical significance. the adequate relation was found between the input variables and response (removal percentage of ...201728167440
characterization of the neurological diseases associated with mycoplasma pneumoniae infection and anti-glycolipid antibodies.mycoplasma pneumoniae infection often causes various neurological complications of both the central nervous system (cns) and the peripheral nervous system. we retrospectively investigated the igm and igg antibodies to nine glycolipids [gm1, gm2, gm3, gd1a, gd1b, gd3, gt1b, gq1b, and gal-c (galactocerebroside)] and clinical features in neurological diseases associated with m. pneumoniae infection diagnosed in multiple hospitals throughout japan between september 2010 and march 2012. of the 46 pat ...201728025664
fitting birth-death processes to panel data with applications to bacterial dna fingerprinting.continuous-time linear birth-death-immigration (bdi) processes are frequently used in ecology and epidemiology to model stochastic dynamics of the population of interest. in clinical settings, multiple birth-death processes can describe disease trajectories of individual patients, allowing for estimation of the effects of individual covariates on the birth and death rates of the process. such estimation is usually accomplished by analyzing patient data collected at unevenly spaced time points, r ...201726702330
diverse families' experiences with hpv vaccine information sources: a community-based participatory approach.current sources of publicly available human papillomavirus (hpv) information may not adequately meet the needs of diverse families. this study sought to describe associations between sociodemographic and acculturation factors, and sources of hpv information among diverse parents and caregivers. community organizations purposively recruited participants from african american, african refugee, hispanic/latino, american indian, and native hawaiian and pacific islander communities for a 21-item surv ...201727734247
human papillomavirus genotyping of incidental malignant and premalignant lesions on hemorrhoidectomy specimens.routine histopathologic examination of hemorrhoidectomy specimens is controversial having been described as not useful and expensive with few of these common cases demonstrating incidental lesions. however, unexpected premalignant and malignant lesions have been detected on excised hemorrhoids. the high-risk human papillomavirus (hr-hpv) types associated with these incidentally identified high-grade lesions are presently unknown. we aimed to identify cases of incidental high-grade anal intraepit ...201728098569
preinvasive and invasive cervical adenocarcinoma: preceding low-risk or negative pap result increases time to diagnosis.the aims of the study were to investigate screening histories of women with adenocarcinoma in situ (ais) and adenocarcinoma (adca) of the cervix and to further evaluate screening for glandular disease.201727977543
effects of l-arginine infusion during ischemia on gut blood perfusion, oxygen tension, and circulating myeloid cell activation in a murine gut ischemia/reperfusion model.gut hypoperfusion is considered to be a mechanism for early multiple-organ failure after severe surgical insults. l-arginine (arg) may preserve gut microcirculation as a substrate of nitric oxide synthase, but simultaneously may enhance immune cell response. it remains unknown if arg infusion during gut ischemia improves the outcome after gut ischemia-reperfusion (i/r).201715291403
comparative efficacy of b-irradiation and mitomycin-c in primary and recurrent pterygium.to determine the efficacy and safety of mitomycin-c as adjunctive treatment and to compare this drug with beta irradiation with strontium-90 after surgical excision of primary and recurrent pterygia.201728226148
disability impact on quality of life in mexican adults with juvenile idiopathic arthritis and juvenile ankylosing spondylitis.our aim was to determine the disability impact on quality of life (qol) in mexican adults with juvenile idiopathic arthritis polyarticular course (jiapa) and juvenile ankylosing spondylitis (jas).201718173931
matrix metalloproteinase 2: an important genetic marker for cholesteatomas.this study is to determine the mmp2s presence in cholesteatomas and whether complicating cholesteatomas show a higher immunohistochemical expression of matrix metalloproteinase 2. cholesteatoma produces enzymes that cause bone erosion like matrix metalloproteinase 2 (mmp2).201717505599
breast-feeding and deleterious oral habits in mouth and nose breathers.breast-feeding promotes several benefits in childhood, among them favoring the nasal breathing. in the present study, the relationship between breathing pattern and the history of breast-feeding and of deleterious oral habits was determined.201716878243
influence of socio-economic and demographic factors in determining breathing patterns: a pilot study.breathing represents one of the vital functions of the organism, and its unbalance causes some series of alterations in several organs and systems.201718278229
estimates of physician productivity: an evaluation.fisher (2007-2008) has carried out an analysis of physician productivity that is the most thorough to date. because of limitations in the data, however, he is forced to make many assumptions to arrive at his estimates. this evaluation describes six assumptions to which the results are likely to be relatively sensitive as well as a number of other assumptions to which the results are likely to be less sensitive.201718435221
comparison of recruitment efforts targeted at primary care physicians versus the community at large for participation in alzheimer disease clinical trials.inefficient and delayed recruitment into clinical trials in alzheimer disease are major obstacles impeding progress in the discovery of more effective therapeutic strategies to combat this disease. despite widespread recognition of this problem, limited empirical data demonstrating the effectiveness of specific recruitment strategies are available to guide recruitment endeavors. this study was designed to evaluate the effectiveness of recruitment efforts targeting either the primary care health ...201719571728
study/experimental/research design: much more than statistics.the purpose of study, experimental, or research design in scientific manuscripts has changed significantly over the years. it has evolved from an explanation of the design of the experiment (ie, data gathering or acquisition) to an explanation of the statistical analysis. this practice makes "methods" sections hard to read and understand.201720064054
pilot study to show the feasibility of a multicenter trial of home-based assessment of people over 75 years old.this report describes a pilot study to evaluate feasibility of new home-based assessment technologies applicable to clinical trials for prevention of cognitive loss and alzheimer disease.201720592583
biomarker changes during acute heart failure treatment.biomarker changes may provide physicians with objective evidence of treatment efficacy in patients with acute decompensated heart failure (adhf) and facilitate early hospital discharge. the authors hypothesize that mid-regional-pro-adrenomedullin (mr-proadm), c-terminal-pro-endothelin-1 (ct-pro-et-1), and mid-regional-pro-atrial natriuretic peptide (mr-proanp) change during the first 24 hours of adhf therapy. eligible patients had an emergency department diagnosis of adhf and fulfilled modified ...201722432555
risk factors associated with shoulder pain and disability across the lifespan of competitive swimmers.the prevalence of shoulder pain among competitive swimmers is high, but no guidelines exist to reduce shoulder injuries. elucidating differences between swimmers with and without shoulder pain can serve as a basis for the development of a program to prevent shoulder injury that might lead to pain and dysfunction.201722488280
tnf-r2 expression in acquired middle ear cholesteatoma.acquired middle ear cholesteatoma is a disease which promotes bone erosion resulting in potentially serious complications. the tumor necrosis factor alpha (tnf-α) is present in cholesteatoma and it is related to bone erosion, as shown by different authors. to understand the aggressiveness characteristics of cholesteatoma is necessary, however, to better address the presence and distribution of their receptors.201721860983
volubility as a mediator in the associations between conversational language measures and child temperament.despite support for the use of conversational language measures, concerns remain regarding the extent to which they may be confounded with aspects of child temperament, extraversion in particular.201722026571
early response of hepatic malignancies to locoregional therapy-value of diffusion-weighted magnetic resonance imaging and proton magnetic resonance spectroscopy.the objective of our study was to determine the usefulness of the diffusion-weighted magnetic resonance imaging and proton magnetic resonance spectroscopy (h-mrs) of hepatic malignancies for the assessment of response to locoregional treatment.201721412085
[iodine concentration in the blood and urine in children depending on the goiter size].epidemiological investigations have shown that at the białystok province about 30% of children and youth is afflicted with goitre. in this area drinking water is poor in iodine and iodine supply with food is quite unsatisfactory. the purpose of the present work has been to check the behaviour of the serum and urine iodine in children with thyroid goitre. the estimations of i in blood serum were made in 126 children with goitre (i, ii, and iii, according to the who classification) and in 100 heal ...2017575329
fisher and seddon: two who've got the right stuff. 20176371111
professor sir ronald fisher, frs. 20172279171
inter- and intra-individual probability maps in eeg cartography by use of nonparametric fisher tests.the three types of non-parametric permutation fisher tests have been applied to inter-individual group studies and further to intra-individual multiple eeg recording sequences, providing computations of eeg probability maps testing two ordinal hypotheses. two examples of previous group studies with "eeg local cerebral activation" are given: mental computation in a group of 20 controls and caffeine effects versus placebo in a group of 10 controls. for the intra-individual study, two successive re ...20172641478
signalling by protein kinase c isoforms in the heart.understanding transmembrane signalling process is one of the major challenge of the decade. in most tissues, since fisher and krebs's discovery in the 1950's, protein phosphorylation has been widely recognized as a key event of this cellular function. indeed, binding of hormones or neurotransmitters to specific membrane receptors leads to the generation of cytosoluble second messengers which in turn activate a specific protein kinase. numerous protein kinases have been so far identified and roug ...20178739230
classic versus sequential diagnostic support for chronic nonspecific respiratory diseases.the authors discuss two approaches to assisted medical diagnosis of chronic nonspecific respiratory diseases, bayes-fisher linear discrimination and a decision tree based on the linear discriminant functions of the individual nodes. only the two most discriminative variables obtained for differentiation of groups at individual nodes are used for the node subclassification. they are the four linguistic variables cough, character of dyspnea, physical examination of the chest, and x-ray examination ...20178483394
arthroscopic anterior labral reconstruction using a transglenoid suture technique. results in active-duty military patients.we report the clinical outcome of arthroscopic labral reconstruction using a transglenoid suture technique in a young, active-duty military population. forty-eight patients (49 shoulders) with varying degrees of glenohumeral instability underwent arthroscopic labral reconstruction using a transglenoid suture technique. all patients had traumatic injuries to their shoulders and all patients had magnetic resonance imaging scans demonstrating anterior labral tears. postoperatively, the patients' sh ...20178734874
dorso-lumbar pain as the first manifestation of miller fisher syndrome. 20179706441
infection of eight mesocarnivores in new hampshire and vermont with a distinct clade of canine distemper virus in 2016-2017.three fishers (martes pennanti), 2 gray foxes (urocyon cinereoargenteus), 1 mink (neovison vison), 1 skunk (mephitis mephitis), and 1 raccoon (procyon lotor), from vermont and new hampshire, had lesions on autopsy consistent with canine distemper virus (cdv) infections diagnosed in a 12-mo period in 2016-2017. lesions of cdv infection were most commonly noted in the lungs (8 of 8 animals), urothelium (5 of 8), biliary tract (5 of 8), gastrointestinal tract (4 of 7), and brain (4 of 6). splenic l ...201931023162
genetic characteristics of canine distemper viruses circulating in wildlife in the united states.canine distemper virus (cdv) is a highly contagious disease of wild and domestic mammals. maintenance of cdv among wildlife plays an important role in the disease epidemiology. wild animals, including raccoons (procyon lotor) and gray foxes (urocyon cinereoargenteus), serve as reservoirs of cdv and hamper the control of the disease. recently, we discovered that at least three different cdv lineages (america-3 [edomex], america-4, and america-5] that are genetically different from the available v ...202031926508
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