| as-186 compounds, new inhibitors of acyl-coa: cholesterol acyltransferase from penicillium asperosporum ky1635. | as-186a, b, c, d, and g were isolated from the cultured broth of penicillium asperosporum ky1635 as inhibitors of acyl-coa: cholesterol acyltransferase (acat). ic50 values for the effect of as-186a, b, c, d, and g against acat activity of the microsomes from cholesterol-fed rabbit liver were calculated to be 22.9, 8.2, 11.5, 12.4, and 13.9 microm, respectively. although as-186a, and b were identical to penicillide and purpactin a, respectively, as-186c, d, and g were found to be new compounds. | 1994 | 8119857 |