Publications

antiquorum sensing and antibiofilm potential of capparis spinosa.	emergence of antibiotic resistance among bacterial pathogens often leads to the failure of existing antibiotics to treat bacterial infections; thus, there is a need to seek alternative treatment measures. the aim of this study was to evaluate the anti-quorum sensing (anti-qs) and antibiofilm potential of capparis spinosa to prevent the onset of bacterial infections as an alternate to antibiotics.	2011	22222491
florida's tin can caper.		2011	5040555
nematicidal activity of 2-thiophenecarboxaldehyde and methylisothiocyanate from caper (capparis spinosa) against meloidogyne incognita.	new pesticides based on plant extracts have recently gained interest in the development of nontoxic crop protection chemicals. numerous research studies are focused on the isolation and identification of new active compounds derived from plants. in this manuscript we report about the use of the mediterranean species capparis spinosa as a potent natural nematicidal agent against the root knot nematodes meloidogyne incognita. leaves, stems, and caper buds of capparis spinosa were used to obtain th ...	2012	22769561
qualitative content analysis of complementary topical therapies used to manage diabetic foot in jordan.	in order to alleviate diabetic foot problems, patients sometimes seek complementary therapies outside the professional context. this paper describes the use of complementary remedies as a topical treatment for diabetic foot ulcers among jordanians. qualitative content analysis was used to analyse written responses of 68 patients with diabetes who have used complementary therapies to treat diabetic foot problems. these 68 persons represented a subgroup of the study population surveyed using a que ...	2012	23983379
caper-α alternative splicing regulates the expression of vascular endothelial growth factor₁₆₅ in ewing sarcoma cells.	tc-71 ewing sarcoma cells overexpress vascular endothelial growth factor (vegf) with a shift from the 189 to the 165 isoform.	2012	22009261
the use of capecitabine in daily practice: a study on adherence and patients' experiences.	adherence to pharmacological therapy is a complex and multifactorial issue that can substantially alter the outcome of treatment. especially when using long-term medication, cancer patients have adherence rates similar to those of patients with other diseases. the consequences of poor adherence are poor health outcomes and increased health care costs. only few studies have focused on the use of oral anticancer agents in daily practice. information about the reasons for nonadherence is essential ...	2012	23118530
identification of glucosinolates in capers by lc-esi-hybrid linear ion trap with fourier transform ion cyclotron resonance mass spectrometry (lc-esi-ltq-fticr ms) and infrared multiphoton dissociation.	an liquid chromatography-mass spectrometry method using electrospray ionization in negative ion mode coupled with a hybrid quadrupole linear ion trap and fourier transform ion cyclotron resonance (fticr) mass spectrometer was applied to characterize of intact glucosinolates (glss) in crude sample extracts of wild bud flowers of capparis spinosa (capparis species, family capparaceae). structural information of glss was obtained upon precursor ions' isolation within the fticr trapping cell and sub ...	2012	22972784
trace element mobility and transfer to vegetation within the ethiopian rift valley lake areas.	to evaluate critical trace element loads in native vegetation and calculate soil-to-plant transfer factors (tfs), 11 trace elements (cr, co, ni, cu, zn, as, se, mo, cd, pb and mn) have been determined in leaves of 9 taxonomically verified naturally growing terrestrial plant species as well as in soil samples collected around 3 ethiopian rift valley lakes (koka, ziway and awassa). the cr concentration in leaves of all the plant species was higher than the "normal" range, with the highest level (8 ...	2012	22907177
structural characterization of a homogalacturonan from capparis spinosa l. fruits and anti-complement activity of its sulfated derivative.	a water-soluble polysaccharide csps-2b-2 with a molecular mass of 8.8 kda, was obtained from the fruits of capparis spinosa l. chemical and nmr spectral analysis verified csps-2b-2 was a linear poly-(1-4)-α-d-galactopyranosyluronic acid in which 12.9±0.4% of carboxyl groups existed as methyl ester and 2.6±0.1% of d-galpa residues were acetylated. a sulfated derivative sul-2b-2 with a sulfation degree of 0.88±0.02 was prepared via the substitution of c-2 and/or c-3 of galpa residues in csps-2b-2. ...	2012	22752400
the anticarcinogenic potential of essential oil and aqueous infusion from caper (capparis spinosa l.).	the present study assessed the influence of essential oil and aqueous infusion from wild-grown caper (capparis spinosa l.) on cell growth, nf-κb activation, apoptosis and cell cycle in the human colon carcinoma cell line, ht-29. methyl isothiocyanate (92.06%), a degradation product of glucosinolate glucocapparin, was detected as major component of essential oil from caper leaves and flower buds. aqueous infusion of caper showed an interesting and variegate compositional pattern containing severa ...	2012	26434289
screening of immunomodulatory activity of total and protein extracts of some moroccan medicinal plants.	herbal and traditional medicines are being widely used in practice in many countries for their benefits of treating different ailments. a large number of plants in morocco were used in folk medicine to treat immune-related disorders. the objective of this study is to evaluate the immunomodulatory activity of protein extracts (pes) of 14 moroccan medicinal plants. this activity was tested on the proliferation of immune cells. the prepared total and pes of the plant samples were tested using mtt ( ...	2013	22301818
capparis spinosa l. (caper) fruit extract in treatment of type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial.	capparis spinosa l. (caper) fruit is traditionally used as an anti-hyperglycemic food by iranian diabetic patients. but yet, no controlled human study has determined its efficacy in treatment of hyperglycemia in type 2 diabetic patients.	2013	24050578
coupling hplc-spe-nmr with a microplate-based high-resolution antioxidant assay for efficient analysis of antioxidants in food--validation and proof-of-concept study with caper buds.	this work describes the coupling of a microplate-based antioxidant assay with a hyphenated system consisting of high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance spectroscopy, i.e., hplc-spe-nmr/high-resolution antioxidant assay, for the analysis of complex food extracts. the applicability of the microplate-based antioxidant assay for high-resolution screening of common food phenolics as well as parameters related to their trapping efficiency, elution behav ...	2013	23993578
food allergy to caper (capparis spinosa).		2013	23653983
caper: a chromosome-assembled human proteome browser.	high-throughput mass spectrometry and antibody-based experiments have begun to produce a large amount of proteomic data sets. chromosome-based visualization of these data sets and their annotations can help effectively integrate, organize, and analyze them. therefore, we developed a web-based, user-friendly chromosome-assembled human proteome browser (caper). to display proteomic data sets and related annotations comprehensively, caper employs two distinct visualization strategies: track-view fo ...	2013	23256906
mineral contents of seed and seed oils of capparis species growing wild in turkey.	the mineral contents of seed and seed oils of capparis species growing wild in turkey were established by inductively coupled plasma-atomic emission spectrometry. capparis spinosa var. spinosa (2010) and capparis ovata var. canescens variety (2009) were determined to be rich in terms of mineral matter as 19,514.60 and 16,995.92 ppm as a total, respectively. c. spinosa var. spinosa collected from muğla-milas region (2009) had the highest amount of ca with 1,010.67 ppm in c. spinosa species and in ...	2014	23925865
the durative use of suspension cells and callus for volatile oil by comparative with seeds and fruits in capparis spinosa l.	capparis spinosa is one of the most important eremophytes among the medicinal plants, and continued destruction of these plants poses a major threat to species survival. the development of methods to extract compounds, especially those of medicinal value, without harvesting the whole plant is an issue of considerable socioeconomic importance. on the basis of an established system for culture of suspension cells and callus in vitro, gas chromatograph-mass spectrometer (gc-ms) was used for the vol ...	2014	25422894
n-butanol extract of capparis spinosa l. induces apoptosis primarily through a mitochondrial pathway involving mptp open, cytochrome c release and caspase activation.	capparis spinosa l., a uygur medicine, had been shown to have anti-tumor activity in our early experiments with an n-butanol extract (csbe) as its active fraction. however, the mechanisms responsible for its effects are not clearly understood. here, we report that treatment of sgc-7901 cells with csbe resulted in dose-dependent reduction of cell viability and induction of apoptosis.	2014	25422194
syrian bean-caper (zygophyllum fabago l.) improves organic matter and other properties of mine wastes deposits.	the omni-presence of zygophyllum fabago l. (syrian bean-caper) natural colonies in post mining areas prompted us to investigate its contributions to reclamation of mine wastes deposits in southeast spain. select plant-related (edaphic) characteristics and bio- and water soluble-cd, cu, pb and zn in rhizosphere of z. fabago were compared to deposits one year since application of pig slurry and marble waste. total n in rhizosphere increased up to a factor of 20x (339 vs 17 mg n kg(-1)) in el gorgu ...	2014	24912237
the potentiality of botanicals and their products as an alternative to chemical insecticides to sandflies (diptera: psychodidae): a review.	use of chemical pesticides is the current method for controlling sandflies. however, resistance is being developed in sandflies against the insecticide of choice that is ddt (dichlorodiphenyl trichloroethane). botanicals have potential to act as an alternative to chemical insecticides as the crude extracts and active molecules of some plants show insecticidal effect to sandflies. this will lead to safe, easy and environment friendly method for control of sandflies. therefore, information regardi ...	2014	24717195
caper, a novel regulator of human breast cancer progression.	caper is an estrogen receptor (er) co-activator that was recently shown to be involved in human breast cancer pathogenesis. indeed, we reported increased expression of caper in human breast cancer specimens. we demonstrated that caper was undetectable or expressed at relatively low levels in normal breast tissue and assumed a cytoplasmic distribution. in contrast, caper was expressed at higher levels in ductal carcinoma in situ (dcis) and invasive ductal carcinoma (idc) specimens, where it assum ...	2014	24621503
physicochemical properties of seeds of capparis species growing wild in turkey.	while capparis spinosa var. herbaceace (2009) seeds collected from the mardin-midyat region contains the highest protein (22.25%), c. spinosa var. spinosa seeds (2009) collected from the muğla-milas region contained the lowest protein (18.25%). in addition, oil contents of c. spinosa and capparis ovata seeds changed between 27.74 to 31.09 and 28.66 to 31.40%, respectively. crude cellulose contents of c. spinosa and c. ovata seeds were found as 28.24 and 29.67%, respectively. it was found that as ...	2014	24276494
caper 2.0: an interactive, configurable, and extensible workflow-based platform to analyze data sets from the chromosome-centric human proteome project.	the chromosome-centric human proteome project (c-hpp) aims to map and annotate the entire human proteome by the "chromosome-by-chromosome" strategy. as the c-hpp proceeds, the increasing volume of proteomic data sets presents a challenge for customized and reproducible bioinformatics data analyses for mining biological knowledge. to address this challenge, we updated the previous static proteome browser caper into a higher version, caper 2.0 - an interactive, configurable and extensible workflow ...	2014	24261964
anti-helicobactor pylori activity of some jordanian medicinal plants.	natural flora are considered a major source of new agents for the treatment of helicobactor pylori. the plants used in this study were selected based on previous traditional use.	2014	24251817
natural products for the treatment of type 2 diabetes mellitus.	type 2 diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia. high blood sugar can produce long-term complications such as cardiovascular and renal disorders, retinopathy, and poor blood flow. its development can be prevented or delayed in people with impaired glucose tolerance by implementing lifestyle changes or the use of therapeutic agents. some of these drugs have been obtained from plants or have a microbial origin, such as galegine isolated from galega officin ...	2015	26132858
anti-arthritic and antiinflammatory effects of the traditional uighur formula kursi caper in vivo.	kursi caper (kc) is a uighur medicine based on caper which is widely used to treat arthritis and rheumatism, and preliminary studies in our laboratory showed that this traditional formula may possess potent antiinflammatory effects. this study confirms the antiinflammatory effect of kc in the adjuvant induced arthritis (aia) model, the carrageenan and cotton-pellet induced granuloma rat models, and further investigates in vivo the mechanism of action by measuring relevant indicators of anti-arth ...	2015	26434647
correction: caper is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via err-α-gabpa and stress-induced adaptive responses via nf-κb-cmyc.		2015	26075908
effect of capparis spinosa extract on sutural ossification: a stereological study.	to investigate the effects of systemically administered capparis spinosa extract (cse) on expanded sutures in rats via three dimensionally morphometric method (stereological method).	2015	26043444
field approach to mining-dump revegetation by application of sewage sludge co-compost and a commercial biofertilizer.	an approach was devised for revegetation of a mining dump soil, sited in a semiarid region, with basic ph as well as fe and mn enrichment. a field experiment was conducted involving the use of co-compost (a mixture of urban sewage sludge and plant remains) along with a commercial biofertilizer (a gel suspension which contains arbuscular mycorrhizal fungus) to reinforce the benefits of the former. four treatments were studied: unamended soil; application of conditioners separately and in combinat ...	2015	25979296
genetic diversity and host alternation of the egg parasitoid ooencyrtus pityocampae between the pine processionary moth and the caper bug.	the increased use of molecular tools for species identification in recent decades revealed that each of many apparently generalist parasitoids are actually a complex of morphologically similar congeners, most of which have a rather narrow host range. ooencyrtus pityocampae (op), an important egg parasitoid of the pine processionary moth (ppm), is considered a generalist parasitoid. op emerges from ppm eggs after winter hibernation, mainly in spring and early summer, long before the eggs of the n ...	2015	25856082
caper is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via err-α-gabpa and stress-induced adaptive responses via nf-κb-cmyc.	ever since we developed mitochondria to generate atp, eukaryotes required intimate mito-nuclear communication. in addition, since reactive oxygen species are a cost of mitochondrial oxidative phosphorylation, this demands safeguards as protection from these harmful byproducts. here we identified a critical transcriptional integrator which eukaryotes share to orchestrate both nutrient-induced mitochondrial energy metabolism and stress-induced nuclear responses, thereby maintaining carbon-nitrogen ...	2015	25830341
caper 3.0: a scalable cloud-based system for data-intensive analysis of chromosome-centric human proteome project data sets.	the chromosome-centric human proteome project (c-hpp) aims to catalog genome-encoded proteins using a chromosome-by-chromosome strategy. as the c-hpp proceeds, the increasing requirement for data-intensive analysis of the ms/ms data poses a challenge to the proteomic community, especially small laboratories lacking computational infrastructure. to address this challenge, we have updated the previous caper browser into a higher version, caper 3.0, which is a scalable cloud-based system for data-i ...	2015	25794139
dynamic assessment of capparis spinosa buds on survival of periodontal ligament cells using a real-time cell analysis method.	tooth avulsion is the most severe type of traumatic dental injuries and it results in the complete displacement of the tooth out of its socket in alveolar bone. reimplantation of the tooth is considered to be a best treatment modality due to its biological and psychological advantages. its prognosis depends on the extra alveolar time, the storage medium, and the patient's general health.	2015	25772925
physicochemical properties of caper species seed oils collected from two different harvest years.	in this study the physicochemical properties, fatty acid composition and sterol and tocopheol contents of caper species seed oils were determined.	2015	25483130
effect of capparis spinosa l. on cognitive impairment induced by d-galactose in mice via inhibition of oxidative stress.	to determine the phenolic acid levels and dna damage protection potential of capparis spinosa l. seed extract and to investigate the effect of the extract on cognitive impairment and oxidative stress in an alzheimer disease mice model.	2015	26738358
in vitro analysis of the role of the mitochondrial apoptosis pathway in csbe therapy against human gastric cancer.	the caper plant (capparis spinosa l.) was a common uyghur folk medicine, and is a member of the capparidaceae family. in a previous study, the n-butanol extract of c. spinosa l. (csbe) was demonstrated to exert anti-tumor activity; however, the underlying mechanism is currently not understood. the present study aimed to elucidate the mechanism underlying the csbe-induced mitochondrial apoptotic pathway, in order to investigate the anti-tumor effects of this plant extract. csbe-induced apoptosis ...	2015	26668648
genetic diversity analysis of capparis spinosa l. populations by using issr markers.	capparis spinosa l. is an important medicinal species in the xinjiang province of china. ten natural populations of c. spinosa from 3 locations in north, central, and south xinjiang were studied using morphological trait inter simple sequence repeat (issr) molecular markers to assess the genetic diversity and population structure. in this study, the 10 issr primers produced 313 amplified dna fragments, with 52% of fragments being polymorphic. unweighted pair-group method with arithmetic average ...	2015	26662446
contribution of trehalose biosynthetic pathway to drought stress tolerance of capparis ovata desf.	trehalose and the trehalose biosynthetic pathway are important contributors and regulators of stress responses in plants. among recent findings for trehalose and its metabolism, the role of signalling in the regulation of growth and development and its potential for use as a storage energy source can be listed. the xerophytic plant capparis ovata (caper) is well adapted to drought and high temperature stress in arid and semi-arid regions of the mediterranean. the contribution of trehalose and th ...	2015	25294040
open versus endovascular repair of abdominal aortic aneurysm: incidence of cardiovascular events in 632 patients in a department of defense cohort over 6-year follow-up.	abdominal aortic aneurysm (aaa) is common with unacceptably high rates of mortality and morbidity with unknown rates of complications after repair in the department of defense (dod).	2015	25134851
committee on air pollution effects research: 40 years of uk air pollution.	the uk committee on air pollution effects research (caper) was established 40 years ago. this special section was compiled to mark this anniversary. during this time there have been dramatic changes in the composition of the air over the uk. the four papers in this special section of environmental pollution represent the current air pollution effects research focus on ozone and nitrogen deposition, two related issues and are proving from a policy perspective to be quite intractable issues. the u ...	2016	26586631
investigating the effects of capparis spinosa on hepatic gluconeogenesis and lipid content in streptozotocin-induced diabetic rats.	the present study aimed to investigate the effects of administration of capparis spinosa (cs) fruit aqueous extract on liver metabolism in streptozotocin (stz)-induced diabetic rats. the aqueous extract of cs was orally administered at a dose of 20mg/kg for 28 consecutive days and then its effects on blood glucose, lipid and insulin levels in normal and stz diabetic rats were comparatively investigated. furthermore, the effects of cs on the activity and expression of the key enzymes of gluconeog ...	2016	27810780
pharmacological effects of capparis spinosa l.	medicinal plants have been known as one of the most important therapeutic agents since ancient times. during the last two decades, much attention has been paid to the health-promoting effects of edible medicinal plants, because of multiple beneficial effects and negligible adverse effects. capparis spinosa l. is one of the most common medicinal plants, used widely in different parts of the world to treat numerous human diseases. this paper aims to critically review the available scientific liter ...	2016	27406313
effect of flavonoids rich extract of capparis spinosa on inflammatory involved genes in amyloid-beta peptide injected rat model of alzheimer's disease.	alzheimer's disease (ad) is one of the most common forms of neurodegenerative diseases. despite vast ongoing researches focusing on the area, little is known about novel treatments. in this study, we aimed to survey the effects of capparis spinosa (c. spinosa) extract on amyloid-beta peptide (aβ)-injected rat.	2016	27778760
acute effect of capparis spinosa root extracts on rat articular pain.	capparis spinosa l. originates from dry regions of asia and mediterranean basin. in traditional medicine of these areas, infusions from caper root are considered to be beneficial for the treatment of rheumatism, gout and against abdominal pains.	2016	27647009
metabolomic study of wild and cultivated caper (capparis spinosa l.) from different areas of sardinia and their comparative evaluation.	capparis spinosa l. (capparidaceae), also known as caper, is widely known for its very aromatic flower buds (capers),that are largely employed as a flavouring in cooking. capparis species are regarded as a potential source of important bioactive compounds, in fact, due to their botanical relationship with brassica species; they contain glucosinolates, secondary plant metabolites, that have been studied for their potential anticarcinogenic properties. in addition, the presence of other numerous b ...	2016	27489055
capparis spinosa l. promotes anti-inflammatory response in vitro through the control of cytokine gene expression in human peripheral blood mononuclear cells.	capparis spinosa l. is an aromatic plant growing wild in dry regions around the mediterranean basin. capparis spinosa was shown to possess several properties such as antioxidant, antifungal, and anti-hepatotoxic actions. in this work, we aimed to evaluate immunomodulatory properties of capparis spinosa leaf extracts in vitro on human peripheral blood mononuclear cells (pbmcs) from healthy individuals.	2016	27483999
a novel pattern of leaf movement: the case of capparis spinosa l.	a novel type of heliotropic leaf movement is presented for capparis spinosa l., a summer perennial shrub of mediterranean and arid ecosystems. in contrast to plants that demonstrate uniform diaheliotropic and/or paraheliotropic movement for all their foliage, the alternate leaves of c. spinosa follow different movement patterns according to their stem azimuth and the side of the stem that they come from (cluster). additionally, leaf movement for each cluster may not be uniform throughout the day ...	2016	27406206
phylogeographic structure of a tethyan relict capparis spinosa (capparaceae) traces pleistocene geologic and climatic changes in the western himalayas, tianshan mountains, and adjacent desert regions.	complex geological movements more or less affected or changed floristic structures, while the alternation of glacials and interglacials is presumed to have further shaped the present discontinuous genetic pattern of temperate plants. here we consider capparis spinosa, a xeromorphic tethyan relict, to discuss its divergence pattern and explore how it responded in a stepwise fashion to pleistocene geologic and climatic changes. 267 individuals from 31 populations were sampled and 24 haplotypes wer ...	2016	27314028
patterns in volatile emission of different aerial parts of caper (capparis spinosa l.).	we analyzed the spontaneous volatile emission of different aerial parts of the caper (capparis spinosa l.) by hs-spme-gc/ms. we identified 178 different compounds of which, in different proportions based on the sample type, the main ones were (e)-β-ocimene, methyl benzoate, linalool, β-caryophyllene, α-guaiene, germacrene d, bicyclogermacrene, germacrene b, (e)-nerolidol, isopropyl tetradecanoate, and hexahydrofarnesyl acetone. the multivariate statistical analyses seem to point out that the par ...	2016	27276076
inhibitory effect on lipid absorption and variability of chemical constituents from capparis sicula subsp. sicula and capparis orientalis.	in continuation of our research program on mediterranean dietary plants, a bioassay-guided fractionation of extracts from several accessions of capparis sicula subsp. sicula and capparis orientalis aerial parts was carried out. antilipidemic activity of samples was assayed using inhibition of pancreatic lipase. to study the metabolic variability in capparis species, hptlc analyses were performed in order to characterize the species through the detection, isolation, and quantitative evaluation of ...	2016	27138247
ferdinand hasbrouck's nitrous oxide caper--which one?		2016	26978140
an insight on the alkaloid content of capparis spinosa l. root by hplc-dad-ms, ms/ms and (1)h qnmr.	the capparis spinosa l. has a wide distribution in the old world from south europe, north and east africa, madagascar, southwest and central asia to australia and oceania. the consolidated traditional use of c. spinosa root as remedy against different pains in human is well known since the antiquity. various secondary metabolites have been found in caper plant, nevertheless, few studies have been focused to the analysis of root constituents. to date, several free and glycosilated spermidine alka ...	2016	26874255
phenolic contents and antioxidant activity of ethanolic extract of capparis spinosa.	caper plant (capparis spinosa) extracts have been associated with diverse biological activities including anti-oxidant properties. in this work, we characterized the hydro-ethanolic extract obtained from c. spinosa leaves [hydroethanolic extract of c. spinosa (hecs)] by analyzing the content in anti-oxidant compounds such as polyphenols, flavonoids and anthocyanins. further, we evaluated hecs antioxidant activities in vitro using bleaching of 1,1-diphenyl-2-picrylhydrazyl radical and abts test a ...	2016	25377263
shifting tides in the emigration patterns of canadian physicians to the united states: a cross-sectional secondary data analysis.	the relative ease of movement of physicians across the canada/us border has led to what is sometimes referred to as a 'brain drain' and previous analysis estimated that the equivalent of two graduating classes from canadian medical schools were leaving to practice in the us each year. both countries fill gaps in physician supply with international medical graduates (imgs) so the movement of canadian trained physicians to the us has international ramifications. medical school enrolments have been ...	2016	27903252
effect of capparis spinosa linn. extract on lipopolysaccharide-induced cognitive impairment in rats.	cognitive disorders in mankind are not uncommon. apart from neurodegenerative diseases such as alzheimer's (ad), various stresses also affect cognitive functions. plants are known to be potential source of compounds that ameliorate several diseases including cognitive impairment. here, we evaluated effect of aqueous extract of caper (capparis spinosa) buds on lipopolysaccharide-induced cognitive impairment in rats using two different oral doses i.e. 10 (pre-treatment) and 30 mg/rat(post-treatmen ...	2016	26934780
innate immune and growth promoting responses to caper (capparis spinosa) extract in rainbow trout (oncorhynchus mykiss).	cytokine responses, non-specific immune activity and growth promotion effect of dietary caper (capparis spinosa) supplementation were examined in rainbow trout (oncorhynchus mykiss). rainbow trout (12.04 ± 0.71 g) were fed diets containing three doses of caper methanolic extract [0 (control), 0.1 and 0.5 g kg(-1) of feed] for 30 days. at the end of the feeding trial, expression levels of cytokine genes that included il-1β, il-8, tgf-β, il-12p40, tnf-α1 and il-10 in head kidney was analyzed using ...	2016	27546553
optimised method for the analysis of phenolic compounds from caper (capparis spinosa l.) berries and monitoring of their changes during fermentation.	in this work, an ad hoc method to identify and quantify polyphenols from caper berries was developed on high-performance liquid chromatography/electrospray ionisation source/mass spectrometry (hplc-esi-ms). the method was applied during fermentation carried out with lactobacillus pentosus om13 (trial s) and without starter (trial c). a total of five polyphenols were identified. all samples contained high concentrations of rutin. epicatechin was found in untreated fruits, on the contrary querceti ...	2016	26593604
genetic variation of eggplant mottled dwarf virus from annual and perennial plant hosts.	the genetic diversity of eggplant mottled dwarf virus (emdv), a member of the family rhabdoviridae, was studied using isolates collected from different herbaceous and woody plant species and remote geographic areas. sequences corresponding to the n, x, p, y, m and g orfs as well as the untranslated regions (utrs) between orfs were determined from all isolates. low genetic diversity was found in almost all genomic regions studied except for the x orf and the utrs, which were more variable, while ...	2016	26660163
polysaccharide of caper (capparis spinosa l.) leaf: extraction optimization, antioxidant potential and antimicrobial activity.	three-variable-three-level box-behnken design-response surface methodology (bbd-rsm) based on the single-factor experiments was used to optimize the extracting parameters of crude polysaccharides (cpss) from the capparis spinosa leaves (csl) including extraction time (eti, 60-120min), extraction temperature (ete, 60-80°c), and the water/solid ratio (w/s, 6-16). the optimal process conditions in order to the highest yield (6.73%) of csl-cpss were 119.8min eti, 72.84°c ete, and 15.97:1w/s.structur ...	2017	27865953
streptomyces capparidis sp. nov., a novel endophytic actinobacterium isolated from fruits of capparis spinosa l.	a novel endophytic actinobacterial strain, designated egi 6500195t, was isolated from fruits of capparis spinosa. growth occurred at 10-45 °c (optimum 30 °c), at ph 6-8 (optimum ph 7) and in the presence of 0-1 % (w/v) nacl. strain egi 6500195t shared highest 16s rrna gene sequence similarity (97.74 %) with streptomyces vitaminophilus dsm 41686t and less than 97 % sequence similarity with other members of the genus streptomyces. the diagnostic amino acid in the peptidoglycan was ll-diaminopimeli ...	2017	27902318
bacillus capparidis sp. nov., an endophytic bacterium isolated from roots of capparis spinosa l.	a novel endophytic bacterium, designated strain egi 6500252t, was isolated from the surface-sterilized roots of a medicinal plant (capparis spinosa l.) collected from urumqi city, xinjiang, north-west china. cells were gram-stain-positive, non-motile, aerobic, catalase- and oxidase-positive, rod-shaped and did not display spore formation. strain egi 6500252t grew at 10-40 °c (optimum 25-30 °c), at ph 6.0-8.0 (optimum ph 7.0) and in the presence of 0-10 % (w/v) nacl (optimum 0-3 %). the major cel ...	2017	27902223
antioxidant and antitumor activities of capparis spinosa l. and the related mechanisms.	the 'ethnodrug' capparis spinosa l. has several pharmacological activities. first, it was found in previous experiments that an ethyl acetate extract of capparis spinosa l. (cse) exhibited antioxidant activity. in order to further research this finding, the present study investigate the blood biochemical indices, injury, energy metabolism, oxidative damage and mitochondrial membrane potential (δψm) level of cardiac cells to study the effect of cse on doxorubicin-induced cardiac toxicity. cse had ...	2017	27878299
capparis spinosa l. aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic mice.	as the aqueous extract of capparis spinosa (cs) possess antidiabetic effect, he present study aims to reveal the possible mechanism of action of cs in diabetic mice.	2017	28348974
anti-inflammatory potential of capparis spinosa l. in vivo in mice through inhibition of cell infiltration and cytokine gene expression.	several chronic inflammatory diseases are characterized by inappropriate cd4+ t cell response. in the present study, we assessed the ability of capparis spinosa l. (cs) preparation to orientate, in vivo, the immune response mediated by cd4+ t cells towards an anti-inflammatory response.	2017	28143472
euphorbia factor l2 induces apoptosis in a549 cells through the mitochondrial pathway.	euphorbia factor l2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of euphorbia lathyris l.), has been traditionally applied to treat cancer. this article focuses on the cytotoxic activity of euphorbia factor l2 against lung carcinoma a549 cells and the mechanism by which apoptosis is induced. we analyzed the cytotoxicity and related mechanism of euphorbia factor l2 with an mtt assay, an annexin v-fitc/pi test, a colorimetric assay, and immunoblotting. euphorbia factor l2 ...	2017	28119809
capparis spinosa fruit ethanol extracts exert different effects on the maturation of dendritic cells.	capparis spinosa l. (c. spinosa) has been used as food and traditional medicine and shows anti-inflammatory and anti-oxidant activities. here, we prepared the c. spinosa fruit ethanol extracts (cses) using different procedures and investigated the effects of cse on the maturation of mouse bone marrow-derived dendritic cells (dcs) in the absence or presence of lipopolysaccharide (lps). dc maturation and cytokine production were detected by flow cytometry and elisa, respectively. we obtained three ...	2017	28067853
capparis spinosa leaves extract: source of bioantioxidants with nephroprotective and hepatoprotective effects.	capparis spinosa, capparidaceae, is largely distributed all over the mediterranean basin and is traditionally used to treat many illnesses, such as liver and kidney diseases. the aim of the current study was to explore the antioxidant, nephroprotective and hepatoprotective effects of methanolic extract of capparis spinosa leaves (mecs) associated with its phytochemical content. the levels of total phenolics, flavonoids and condensed tannins were 23.37mggae/g, 9.05mgqe/g and 9.35mgtae/g, respecti ...	2017	28056421
capparis spinosa reduces doxorubicin-induced cardio-toxicity in cardiomyoblast cells.	doxorubicin (dox) is an effective anticancer drug but its clinical application is limited because it induces apoptosis in cardiomyocytes and leads to permanent degenerative cardiomyopathy and heart failure possibly due to oxidative stress. recent studies showed that capparis spinosa (c. spinose) exhibits potent antioxidant activity. so, in this study, we explored the protective effect of hydro-alcoholic extract of c. spinosa against dox-induced cytotoxicity in h9c2 cells.	2017	27761417
genetic diversity and population structure of six species of capparis in tunisia using aflp markers.	in order to study the genetic diversity, the phylogeographic pattern and hybridization between six tunisian capparis species, 213 accessions of caper were genotyped with three primer combinations of amplified fragment length polymorphism (aflp) markers. out of 750 fragments generated, 636 were polymorphic and 407 of them were restricted to a single species. structure and pcoa analyses clearly separated morphologically different populations into six distinct genetic ones. the upgma analysis group ...	2017	27697367
anti-diabetic effect of capparis spinosa l. root extract in diabetic rats.	diabetes mellitus is the most common metabolic disorders with severe impact on quality of life. reducing serum glucose levels and normalization of serum lipid is of great clinical importance for treating diabetes. to our knowledge, there are not any evidences about the anti-diabetic action of capparis spinosa root. in the present study the effects of the c. spinosa root extract on diabetic metabolic disorders have been studied in experimental diabetes.	2017	26445712
capparis spinosa l. in a systematic review: a xerophilous species of multi values and promising potentialities for agrosystems under the threat of global warming.	caper (capparis spinosa l.) is a xerophytic shrub with a remarkable adaptability to harsh environments. this plant species is of great interest for its medicinal/pharmacological properties and its culinary uses. its phytochemical importance relies on many bioactive components present in different organs and its cultivation can be of considerable economic value. moreover, taxonomic identification of c. spinosa l. has been difficult due to its wide heterogeneity, and many authors fell into confusi ...	2017	29118777
antioxidant and diuretic activity of co-administration of capparis spinosa honey and propolis in comparison to furosemide.	to study the antioxidant properties of capparis spinosa (c. spinosa) honey and propolis and the effect of combined honey and propolis administration on urine volume and electrolytes in rats.	2017	29111193
selected hepatoprotective herbal medicines: evidence from ethnomedicinal applications, animal models, and possible mechanism of actions.	insight into the hepatoprotective effects of medicinally important plants is important, both for physicians and researchers. main reasons for the use of herbal medicine include their lesser cost compared with conventional drugs, lesser undesirable drug reactions and thus high safety, and reduced side effects. the present review focuses on the composition, pharmacology, and results of experimental trials of selected medicinal plants: silybum marianum (l.) gaertn., glycyrrhiza glabra, phyllanthus ...	2017	29047177
antidiabetic properties of capparis spinosa l. and its components.	an increasing line of evidence confirmed that apart from conventional hypoglycemic drugs, diet and medicinal plants have beneficial effects on diabetes. capparis spinosa l. (caper) is a perennial shrub in the capparidaceae family. it grows in different regions of the world, particularly in asian and african countries. a wide range of biological activities such as antioxidant, anti-inflammatory, anticancer, antimicrobial, and antidiabetic effects have been reported for this plant. in this review, ...	2017	28551550
phytochemical and pharmacological properties of capparis spinosa as a medicinal plant.	over the past decades, there has been increasing attention on polyphenol-rich foods including fruits and vegetables on human health. polyphenols have been shown to possess some potential beneficial effects on human health and they are widely found in foods consumed by populations worldwide. capparis spinosa (c. spinosa) is an important source of different secondary metabolites of interest to humankind. the traditional therapeutic applications of c. spinosa have been reported in ancient romans. n ...	2018	29364841
antioxidant and hepatoprotective effects of capparis spinosa l. fractions and quercetin on tert-butyl hydroperoxide- induced acute liver damage in mice.	the present study investigates the antioxidant and hepatoprotective effects of capparis spinosa l. and quercetin in tert-butyl hydroperoxide (t-bhp) induced acute liver damage. different fractions of c. spinosa were examined for total phenolic content and antioxidant property. among these fractions, hydroalcoholic extract was used to assess the hepatoprotective effect in tert-butyl hydroperoxide (t-bhp) induced hepatotoxicity model by determining serum biochemical markers, sleeping time and anti ...	2018	29321999
geochemical caper fingerprints as a tool for geographical origin identification.	the identification of geographical origin of food products is important for both consumers and producers to ensure quality and avoid label falsifications. the caper plant (capparis spinosa l., brassicales capparidaceae), a xerophytic shrub common in the mediterranean area, produces buds and fruits that are commercialized in brine at high price. those grown in italy in the aeolian islands are renowned for their high quality. this study is aimed to establish a correlation between the geological an ...	2018	29299859