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[relationship between the cause and length of posterior malleolar fragment and treatment strategies for posterior malleolar fracture in adult patients].to explore the relationship between the causes and length of posterior malleolar fragment and treatment strategies of adult patients with three types of ankle joint injury.201122333613
[a comparative clinical analysis of thoracic sarcoidosis and multi-organ sarcoidosis].to investigate the clinical characteristics of thoracic sarcoidosis compared with multi-organ sarcoidosis.201122333504
[impact of age and sex on virologic responses of peginterferon alfa-2a and ribavirin treatment in chronic hepatitis c].to investigate the impact of age and sex on virologic responses rates to peginterferon alfa-2a and ribavirin treatment in patients with chronic hepatitis c.201122333166
effect of changes in the intake of weight of specific food groups on successful body weight loss during a multi-dietary strategy intervention trial.distinct weight loss dietary strategies are associated with changes in specific food groups.201122331684
arsenic level in ground and surface water in predominantly rural areas of golaghat sub-division in golaghat district, assam, india.this paper reports the quality of ground and surface water with respect to arsenic from 33 different sources in predominantly rural area of golaghat sub-division in golaghat district of assam (india). water samples were collected during the pre-monsoon (feb) and post-monsoon (oct) seasons of 2008. the results are analyzed in the light of possible health hazards from arsenic in relation to their maximum contaminant level (mcl) 10 ppb recommended by usepa (2001) guideline value as well as who (199 ...201122324149
[clinicopathologic analysis of vulnerable plaque in autopsy with acute coronary syndrome].to observe pathohistological features of vulnerable plaques in coronary arteries.201122321226
chaetognatha in the bahía magdalena lagoon complex, baja california sur, méxico: species composition and assemblages.the chaetognaths from 187 zooplankton samples collected from the bahia magdalena lagoon complex, baja california sur, mexico during march, june, july, august, september, november, and december 1982 were studied. twelve species belonging to two genera were identified. sagitta euneritica and s. enflata were the most abundant and most frequent species with maximum abundance in july (40,000 org/100 m(3) and 6100 org/100 m(3) respectively). sagitta pacifica, s. regularis and s. pseudoserratodentata w ...201122315819
estimation of absorbed cadmium in tissues of male and female albino rats through different routes of administration.the resultant effects of cadmium exposure are seen in almost all the systems of the body, however, this study is designed to quantify its accumulation in tissues of animals exposed to cadmium. the rats were divided into two distinct groups of males and females, which were then divided into three groups, each for the monitoring of exposure. group 1 served as control male and female and received normal rat chow and tap water. group 2 males and females were treated with 5 mg/kg body weight of cadmi ...201122314995
[obtaining and characteristic of streptomyces globisporus 1912 mutants with high biosynthesis of landomycin e].eight highly productive uv-induced mutants of streptomyces globisporus 1912 with high biosynthesis of landomycin e were isolated, their isolation frequency being 2 x 10(-3). mutants 1-1, 1-4-1, 1-1y, 1-2y, 4-1, 1-2 produced 175-187.5 mg of landomycine e and 1-1b, 4-1-1 and 1-3--80-100 mg per 1 liter of soybean agar after 48 hours of cultivation the mutant 4-1-1 had the highest antibiotic activity and middle level of landomycin e production.201122308749
frequency of two common hfe gene mutations (c282y and h63d) in a group of iranian patients with cryptogenic cirrhosis.the human hfe gene (a key component of iron homeostasis in humans) is involved in hereditary hemochromatosis, a common autosomal recessive genetic disorder that is characterized by excessive intestinal iron absorption and progressive iron overload.201122308152
epidemiology of amyotrophic lateral sclerosis patients in a centre in buenos aires.sporadic amyotrophic lateral sclerosis (sals) is considered a multifactorial disease with genetic and environmental factors causing motor neuron degeneration.201122297869
thoracic aortic atheroma severity predicts high-risk coronary anatomy in patients undergoing transesophageal echocardiography.we hypothesized a relationship between severity of thoracic aortic atheroma (aa) and prevalence of high-risk coronary anatomy (hrca).201122291734
safety of carbon dioxide digital subtraction angiography.reports of fatality following carbon dioxide digital subtraction angiography (co2-dsa) have raised concerns regarding its safety. this study reviews the safety of co2-dsa.201122288088
predictors of future cognitive decline in persons with mild cognitive impairment.this study sought first to identify individual items of the mini-mental state examination (mmse) and demographic variables at baseline that predicted the trajectories of cognitive change among patients with mild cognitive impairment (mci), and second to quantify the risk of cognitive decline in such patients based on their pattern of failure of mmse items. 187 mci patients were evaluated serially with the mmse for up to 3.5 years. patients who followed a declining cognitive trajectory differed f ...201122286544
[arrhythmogenic effects of alcohol].acute or chronic excessive consumption of alcohol can cause cardiac arrhythmias, particularly supraventricular tachyarrhythmias. experimental and clinical data show that chronic excessive alcohol ingestion has a destructive role on cardiac tissue, which significantly deteriorates the rhythm and contractile activity, manifested by the appearance of cardiac arrythmias and dilated cardiomyopathy.201122276445
blastomere number and pregnancy rates in the succeeding in vitro fertilization cycle in women who formed all embryos with < or = 5 blastomeres.to determine the likelihood of pregnancy following the transfer of embryos all with slow cleavage to day 3. furthermore to determine the likelihood that if slow cleavage happens once, it is likely to repeat.201122268262
[phylogenetic diversity characteristics of soil bacteria producing nematode-attracting volatiles and identification of their active compounds].this study characterized the phylogenetic diversity of soil bacteria producing nematode-attracting volatiles and their nematode-attracting compounds. results would enhance our understanding on the interaction between nematodes and soil microorganisms and potentially enhance the biocontrol efficiency when combined the attractants with nemacides.201122260042
[preparation and characterization of wood/methylolurea composite with in-situ polymerization].wood/methylolurea composite was prepared with the in-situ polymerization. the green timber with high moisture content was impregnated by a pulse-dipping machine and then was dried in a hot-press drying kiln. the cross-linking reaction was taken under the heat treatment between the wood modifier and the wood composition, including cellulose, hemicelluloses, and lignin. the chemical composition was analyzed according to the chinese standard, including x-ray photoelectron spectroscopy (xps), nuclea ...201122242521
life events, sibling warmth, and youths' adjustment.sibling warmth has been identified as a protective factor from life events, but stressor-support match-mismatch and social domains perspectives suggest that sibling warmth may not efficiently protect youths from all types of life events. we tested whether sibling warmth moderated the association between each of family-wide, youths' personal, and siblings' personal life events and both depressive symptoms and risk-taking behaviors. participants were 187 youths aged 9-18 (m = 11.80 years old, sd = ...201122241934
[quality of life of adults with spinal cord injury: a study using the whoqol-bref].the objective of this study was to evaluate the quality of life (qol) of adults with spinal cord injury and to identify the domains that may influence qol. data was collected using the whoqol-bref and a questionnaire with sociodemographic variables. participants were 47 subjects, with a mean age of 42.95 years, 91.5% males and 8.5% females. the domains obtained the following scores: physical (58.59), psychological (63.82), social (68.79), and environmental (55.20). through multiple linear regres ...201122241194
evaluation of minichromosome maintenance protein 7 as a prognostic marker in canine cutaneous mast cell tumours.minichromosome maintenance proteins (mcms) are sensitive markers of cellular proliferation and have been shown to be significant predictors of survival in several human malignancies. mcm7 was evaluated as a prognostic marker in canine cutaneous mast cell tumours (mcts). mcm7 immunohistochemistry was performed and an index of mcm7-positive cells calculated in dogs with known outcome. the receiver operating characteristics method was used to individuate the best cut-off value of mcm7 score as pred ...201122235877
channelpedia: an integrative and interactive database for ion channels.ion channels are membrane proteins that selectively conduct ions across the cell membrane. the flux of ions through ion channels drives electrical and biochemical processes in cells and plays a critical role in shaping the electrical properties of neurons. during the past three decades, extensive research has been carried out to characterize the molecular, structural, and biophysical properties of ion channels. this research has begun to elucidate the role of ion channels in neuronal function an ...201122232598
a spectrometer designed for 6.7 and 14.1 t dnp-enhanced solid-state mas nmr using quasi-optical microwave transmission.a dynamic nuclear polarisation (dnp) enhanced solid-state magic angle spinning (mas) nmr spectrometer operating at 6.7 t is described and demonstrated. the 187 ghz te(13) fundamental mode of the fu cw vii gyrotron is used as the microwave source for this magnetic field strength and 284 mhz (1)h dnp-nmr. the spectrometer is designed for use with microwave frequencies up to 395 ghz (the te(16) second-harmonic mode of the gyrotron) for dnp at 14.1t (600 mhz (1)h nmr). the pulsed microwave output fr ...201122218011
preoperative breast mri in the surgical treatment of ductal carcinoma in situ.accurate determination of the size or extent of ductal carcinoma in situ (dcis) by imaging is uncertain, and incomplete resection of tumor results in involved margins in up to 81% of cases. this study examined the accuracy of magnetic resonance imaging (mri) for assessment of dcis size, and evaluated the effect of preoperative breast mri on achievement of tumor-free surgical margins after breast-conserving surgery (bcs). one-hundred and fifty-eight female patients with dcis were identified from ...201122211816
the evaluation of microcarcinoma in differentiated thyroid cancers according to old and new tnm classification.objective: in this study, we aimed to evaluate the tumor size for proximal and distant metastases when the new and old tnm classification is taken into account in differentiated thyroid cancers. material and methods: two hundred sixty eight patients diagnosed with thyroid carcinoma, undergoing bilateral total or subtotal thyroidectomy treated with high doses of i-131 were examined retrospectively. the data of these patients were compared after classification, according to tumor size <1 cm and <2 ...201123486990
9-p-tolyl-9h-carbazole-3-carbonitrile.in the title compound, c(20)h(14)n(2), the carbazole ring system is essentially planar (r.m.s. deviation = 0.187 å) and is inclined at an angle of 54.33 (4) ° with respect to the benzene ring. the crystal packing is stabilized by weak c-h⋯n and c-h⋯π inter-actions.201122058824
[acceptability criteria of spirometry in young workers].it is uncertain the forced expiratory time (fet) acceptable during spirometry of young people (16-20 years old) because they are not children nor adults. we studied 235 boys and 187 girls of this age and, comparing spirometries with fet > 3 s and > 6 s, we found no significative difference (t test) between vext, dtpef, fvc and fev1 repeatibility, while for wheight in males (p =0.0022) and plateau time (p < 0.00001) in males and females. we conclude that blows with fet < 6s but > 3s can be accept ...201123393858
prejudicial attitudes toward clients who are obese: measuring implicit attitudes of occupational therapy students.abstract stigmatizing attitudes can undermine the quality of health care. this study examines the attitudes and beliefs of 189 occupational therapy students toward clients who are obese. results indicate that the occupational therapy students were more likely to make negative evaluations of clients who were obese. the univariate between-subjects analysis of the attitudes toward obesity-prejudicial evaluation and social interaction scale scores found that the difference between the means for over ...201123898985
eight years of outcomes of the dutch living donor kidney exchange program.in january 2004, the dutch transplant centers agreed on a protocol for a national living donor kidney exchange program for abo blood type incompatible and positive cross match donor-recipient pairs. here, we report the results of that program. all transplants performed within the living donor kidney exchange program between january 2004 and december 2011 were analysed. we collected demographic data of recipients and donors. univariate and multivariate cox proportional hazard analyses were perfor ...201122755421
varicella at sea: a two-year study on cruise ships.being highly contagious by person-to-person transmission, varicella can easily spread within the multinational population of a cruise ship and into communities ashore. the aim of the study was to report the prevalence of varicella infections in a fleet of cruise ships during a two-year period and to discuss measures to prevent and contain shipboard outbreaks.201122544501
[the diagnostics of the obstructive jaundice and possibilities to improve the efficacy of its miniinvasive treatment].the study, which included data of 226 patients with the obstructive jaundice, proved, that the clinical presentation and laboratory tests have secondary role in diagnosing the level of the biliary block. among diagnostic means of detecting the etiology of the obstruction were the ultrasound investigation (n=268); the magnetic resonance cholangiopanreatography (n=143); the multispiral computed tomograpth (n=119); the endoscopic retrograde cholangiopanreatography (n=187) and the transcutaneous tra ...201122413152
formulation and evaluation of transdermal patch of repaglinide.repaglinide has the half life of 1 hour, and bioavailability in the body is 56% due to first-pass metabolism. the total daily dose of repaglinide is 16 mg (e.g., 4 mg four times daily depending on meal patterns); hence, it required frequent dosing. transdermal patch of repaglinide was prepared to sustain the release and improve bioavailability of drug and patient compliance. different formulations were prepared by varying the grades of hpmc and concentration of pvp k30 by solvent casting method. ...201122389856
is opium addiction a risk factor for ischemic heart disease and ischemic stroke?the main source of studies about effects of opium consumption on heart and brain attacks originates from iran therefore the aim of the present study was to assess opium addiction as a probable influencing factor for ischemic heart disease and ischemic stroke.201223825997
serum leptin and adiponectin levels and risk of renal cell carcinoma.objective: the incidence of renal cell carcinoma (rcc) has increased rapidly in the u.s., particularly among african americans. despite a well-established link between obesity and rcc, the mechanism through which obesity increases cancer risk has yet to be established. adipokines, such as leptin and adiponectin, may link obesity and cancer, with different quantitative effects by race. design and methods: we evaluated the association between leptin and adiponectin concentrations and rcc risk amon ...201223666639
[investigation on satisfaction of replacement of bovine with machine for schistosomiasis control of residents in jiangling county, hubei province].to understand the satisfaction and the awareness rate of the replacement of bovine with machine for schistosomiasis control among residents in jiangling county, hubei province.201223593844
abdominal circumference as a screening measure for type 2 diabetes.background no comparative study has been conducted in india considering different anthropometrically derived adiposity measures to study the association with type 2 diabetes. objective this study aims to examine the association of different adiposity measures and to find out the best adiposity measure in assessing type 2 diabetes. method on 187 adult males aged 25-67 years, fasting and two hours postload glucose levels were assessed. height, weight, hip circumference, and waist circumference at ...201223575045
pearl in interhemispheric fissure: a rare phenomenon.epidermoid cysts (keratin pearls) are benign congenital lesions, found commonly in cerebello-pontine angle, suprasellar cistern, sylvian cistern, pineal region, but they are very rare in interhemispheric fissure. approaching these lesions are challenging to neurosurgeons because of narrow and deep fissure with surrounding vital structures. the present study constitutes an analysis of interhemispheric epidermoid managed at our hospital in last 10 years (jan 2001-dec 2010). total 187 cases of intr ...201223559996
patients for patient safety in china: a cross sectional study.to investigate the baseline status of patients' awareness, knowledge, and attitudes to patient safety in china, and to determine the factors that influence patients' involvement in patient safety.201223528115
[assessment of bronchopulmonary immunity status for mayak pa workers at the late period after prolonged exposure].samples of induced sputum from 187 individuals were used to estimate the bronchopulmonary immunity status after a prolonged radiation exposure (120 individuals who are the mayak main plant workers were exposed to combined internal a-radiation due to incorporated plutonium (239pu) and external y-radiation during their career). the control group included 67 ozersk residents of a corresponding age and gender, without any occupational exposure, who were examined at the same period. the immune system ...201223516889
a campaign for information and diagnosis of atrial fibrillation: "pulse week".atrial fibrillation occurs in 5%-15% of elderly patients and causes one-fourth to one-fifth of all cerebrovascular events. these patients are frequently asymptomatic. we conducted a public campaign aiming to evaluate the effectiveness of a program for information on and diagnosis of atrial fibrillation in individuals aged 65 years old or more from the primary care perspective.201223485183
methyl 12-hydroxy-10-[1-(4-meth-oxy-phen-yl)-2-oxo-3-phen-oxy-azetidin-4-yl]-11-oxa-3-aza-hexa-cyclo-[11.7.1.0(2,9).0(2,12).0(3,7).0(17,21)]henicosa-1(20),13,15,17(21),18-penta-ene-9-carboxyl-ate.in the title compound, c37h34n2o7, both pyrrolidine rings adopt envelope conformations. the β-lactam ring is close to planar (r.m.s. deviation = 0.0395 å) and makes a dihedral angle of 83.35 (15)° with the furan ring. the o atom attached to the β-lactam ring deviates by 0.187 (2) å from the mean plane of the ring. the β-lactam ring makes dihedral angles of 14.90 (15) and 27.72 (17)° with the meth-oxy-phenyl and phenyl rings, respectively. the crystal packing features c-h⋯o hydrogen bonds.201223476169
an adapted triage tool (etat) at red cross war memorial children's hospital medical emergency unit, cape town: an evaluation.to evaluate the efficacy of an adapted emergency triage assessment and treatment (etat) tool at a children's hospital.201223472679
preparation and characterization of an extract of german cockroach from a korean source.the cockroach (cr) is an important cause of respiratory allergic disorders. we prepared a german cr extract in a standardized way and analyzed its allergenic properties.201223449858
[dyadic coping and well-being -- the hungarian version of the dyadic coping inventory].in studying coping processes, there is often a focus on individual coping while dyadic processes in couples are seldom addressed. therefore we present here data with the hungarian version of the dyadic coping inventory (dci) that was developed to assess dyadic forms of coping (e.g., stress communication, support, delegated and negative coping).201223429339
efficacy of two compression systems in the management of vlus: results of a european rct.to evaluate the efficacy, tolerance and acceptability an innovative two-layer system (ktwo; laboratoires urgo) versus an established four-layer bandage system (profore; smith & nephew) in the local management of venous leg ulcers.201223413494
[spontaneous bacterial peritonitis in liver cirrhosis: optimization issues of prevention and treatment].research of features of a current of a spontaneous bacterial peritonitis (sbp) allows to allocate close interrelation between sbp, system inflammatory reaction and a sepsis to consider sbp, as one of stages in evolution of the difficult infectious process caused, as a rule, by resident flora, developing at patients with decompensated liver cirrhosis (lc), which demands timely preventive maintenance and adequate antibacterial therapy. in the present work therapy and preventive maintenance sbp que ...201223402188
bone mineral density qtl at sexual maturity and end of lay.1. an f₂ cross of a broiler male line and a white leghorn layer line was used to identify quantitative trait loci (qtl) for bone density at the onset of lay and at the end of the laying period. a total of 686 measures of humeral bone density were available for analysis. 2. there was no evidence for epistasis. 3. genome-wide significant qtl for bone density at the onset of lay were identified on chromosomes 1 (311 cm) and 8 (2 cm) and on chromosomes 1 (311 cm), 3 (57 cm) and 8 (2 cm) with a covar ...201223398420
chronic obstructive pulmonary disease and associated healthcare resource consumption in the middle east and north africa: the breathe study.data on copd-related healthcare resources use are rarely documented in developing countries. this article presents data on copd-related healthcare resource consumption in the middle east, north africa and pakistan and addresses the association of this variable with illness severity. a large survey of copd was conducted in eleven countries of the region, namely algeria, egypt, jordan, lebanon, morocco, pakistan, saudi-arabia, syria, tunisia, turkey and united arab emirates, using a standardised m ...201223290706
attitudes and beliefs about copd: data from the breathe study.although copd is a debilitating pulmonary condition, many studies have shown awareness of the disease to be low. this article presents data on attitudes and beliefs about copd in subjects with respiratory symptoms participating in the breathe study in the middle east and north africa region. this study was a large general population survey of copd conducted in ten countries of the region (algeria, egypt, jordan, lebanon, morocco, saudi arabia, syria, tunisia, turkey and united arab emirates), to ...201223290705
the burden of chronic obstructive pulmonary disease in the middle east and north africa: results of the breathe study.copd is a progressive pulmonary disease which may have a profound impact on general health status and quality of life. this article presents data on the burden of copd obtained from the breathe study in the middle east, north africa and pakistan. this study was a large general population survey of copd conducted in eleven countries of the region using a standardised methodology. a total of 62,086 subjects were screened, of whom 2,187 fulfilled the "epidemiological" definition of copd. data on sy ...201223290704
chronic obstructive pulmonary disease in the adult population within the middle east and north africa region: rationale and design of the breathe study.the objective of the breathe study was to estimate the regional prevalence of chronic obstructive pulmonary disease (copd) symptoms within the general population in the middle east/north africa (mena) region and to document risk factors, disease characteristics and management using a standardised methodology. this was an observational population-based survey performed in ten countries in the middle east and north africa (algeria, egypt, jordan, lebanon, morocco, saudi arabia, syria, tunisia, tur ...201223290702
measurement of the cross section for electromagnetic dissociation with neutron emission in pb-pb collisions at sqrt[s(nn)] = 2.76 tev.the first measurement of neutron emission in electromagnetic dissociation of ^{208}pb nuclei at the lhc is presented. the measurement is performed using the neutron zero degree calorimeters of the alice experiment, which detect neutral particles close to beam rapidity. the measured cross sections of single and mutual electromagnetic dissociation of pb nuclei at sqrt[s(nn)]=2.76 tev with neutron emission are σ(singleemd)=187.4 ± 0.2(stat)(-11.2)(+13.2) (syst) b and σ(mutualemd) = 5.7 ± 0.1(stat) ...201223368454
dynamic minimum pause threshold estimation for speech analysis in studies of cognitive function in ageing.cognitive decline represents the biggest limiting factor to independence in older adults. speech analysis has emerged as an alternative to standard cognitive assessment tools. temporal segmentation of speech is reported in many studies and typically employs a static threshold to define a pause. this study investigated the effect of using pause and utterance duration distribution data in differentiating between cognitively healthy and impaired older adults. three sets of features were extracted f ...201223366731
cancer incidence and mortality in china, 2007.cancer incidence and mortality data collected from population-based cancer registries were analyzed to present the overall cancer statistics in chinese registration areas by age, sex and geographic area in 2007.201223359628
choroidal thickness measurement in highly myopic eyes using sd-oct.to measure macular choroidal thickness (ct) using spectral-domain optical coherence tomography (oct) and to investigate the correlation between ct and age, degree of myopia, and history of macular choroidal neovascularization (cnv).201223357323
association of molecular markers with cold tolerance and green period in zoysiagrass (zoysia willd.).cold tolerance and the green period are key traits in the breeding of zoysiagrass (zoysia willd.). identification of molecular markers associated with cold tolerance and the green period of zoysiagrass will contribute to efficient selection of elite cultivars. these two traits were measured in 96 zoysiagrass accessions in 2004 and 2005-2006, respectively. the mapping population was screened with 29 pairs of simple sequence repeat (ssr) primers and 54 pairs of sequence-related amplified polymorph ...201223341745
[prevention of restenosis with a new modified fully-covered retrievable esophageal stent].to observe and evaluate the effectiveness of a new modified fully-covered retrievable esophageal stent in preventing restenosis at the proximal end of the stent.201223328419
[effects of rna interference targeting p2x7 receptor on microglial phagocytosis of amyloid-β protein].to investigate the effect of silencing p2x7 receptor (p2x7r) by rna interference on microglial phagocytosis of amyloid-β (aβ) protein and to explore its possible mechanism.201223328384
major dietary patterns and risk of asymptomatic hyperuricemia in chinese adults.in this study, we conducted a case-control study to evaluate the association of major dietary patterns and asymptomatic hyperuricemia taking account of blood lipids in chinese adults. 187 cases with confirmed asymptomatic hyperuricemia and 187 controls were frequency matched on age, gender and area of residence. we conducted factor analysis using dietary information from a validated food frequency questionnaire to derive dietary patterns. the association between major dietary patterns and asympt ...201223327969
[epidemiological investigation of 615 patients with chemical burns in eastern china].to investigate the epidemiological factors in the first aid, early management, and treatment of chemical burns.201223327908
detection of haemophilus parasuis isolates from south china by loop-mediated isothermal amplification and isolate characterisation.haemophilus parasuis is the etiological agent of glässer's disease, which is characterised by fibrinous polyserositis, meningitis and polyarthritis, causing severe economic losses to the swine industry. in this study, a loop-mediated isothermal amplification (lamp) test was developed to improve the specificity, facility and speed of diagnosis of h. parasuis isolates. the lamp assay rapidly amplified the target gene within 50 min incubation at 63 °c in a laboratory water bath. the lamp amplicon could ...201223327310
hypokalaemia: common things occur commonly - a retrospective survey.to define the causes of hypokalaemia in an unselected adult population.201223323198
glutathione s-transferase p1 and dna polymorphisms influence response to chemotherapy and prognosis of bone tumors.osteosarcoma is the most common primary bone malignancy in children and adolescents, and its clinical outcome is poor. we evaluated the influence of gstp1, ercc1 and ercc2 polymorphisms on response to chemotherapy among osteosarcoma patients, and the significnace of these genes for prognosis. a total of 187 patients with osteosarcoma were administered methotrexate, cisplatin/adriamycin, actinomycin d, cyclophosphamide, or vincristine. gstp1, ercc1 and ercc2 polymorphisms were genotyped by pcr-rf ...201223317281
[changes in subfoveal choroidal thickness of epiretinal membrane and macular hole before and after microincision vitrectomy surgery].to evaluate the subfoveal choroidal thickness (sct) of the epiretinal membrane (erm) and macular hole (mh) both before and after microincision vitrectomy surgery.201223316656
[analysis of clinical phenotype and mode of inheritance in retinitis pigmentosa patients with consanguineous marriage].to analyse the mode of inheritance and clinical characteristics of retinitis pigmentosa (rp) patients with consanguineous marriage.201223302243
elevated serum heart-type fatty acid-binding protein in the convalescent stage predicts long-term outcome in patients surviving acute myocardial infarction.little is known about the prognostic significance of elevated serum heart-type fatty acid-binding protein (h-fabp) in post-acute myocardial infarction (post-ami) patients.201223291993
[peripheral primitive neuroectodermal tumor of trachea: a case report and review of literatures].to improve the understanding of tracheal peripheral primitive neuroectodermal tumor (pnet).201223290035
modulatory effect of polyphenolic extracts of ichnocarpus frutescens on oxidative stress in rats with experimentally induced diabetes.the role of oxidative stress in the development of diabetes mellitus and its vascular complications are extensively studied. hyperglycaemia causes oxidative damage by generation of reactive oxygen species and results in the development of complications. the present study was undertaken with the objective of exploring the anti-hyperglycaemic potential of polyphenolic enriched extract of ichnocarpus frutescens in streptozotocin induced (n-stz) neonatal diabetic rats (pups) for six weeks and to stu ...201223287129
n-3 poly-unsaturated fatty acids shift estrogen signaling to inhibit human breast cancer cell growth.although evidence has shown the regulating effect of n-3 poly-unsaturated fatty acid (n-3 pufa) on cell signaling transduction, it remains unknown whether n-3 pufa treatment modulates estrogen signaling. the current study showed that docosahexaenoic acid (dha, c22:6), eicosapentaenoic acid (epa, c20:5) shifted the pro-survival and proliferative effect of estrogen to a pro-apoptotic effect in human breast cancer (bca) mcf-7 and t47d cells. 17 β-estradiol (e2) enhanced the inhibitory effect of n-3 ...201223285198
global and focal white matter integrity in breast cancer survivors 20 years after adjuvant chemotherapy.objectives: to date, only four small studies have investigated the effects of adjuvant chemotherapy for breast cancer on the microstructure of cerebral white matter with magnetic resonance imaging (mri). these studies, which were conducted shortly up to 10 years post-treatment, showed that chemotherapy is associated with focal loss of microstructural white matter integrity. we investigated the long-term effect of chemotherapy on white matter microstructural integrity by comparing the brains of c ...201223281152
simultaneous quantitation of ic87114, roflumilast and its active metabolite roflumilast n-oxide in plasma by lc-ms/ms: application for a pharmacokinetic study.a sensitive and reliable high-performance liquid chromatography-mass spectrometry (lc-ms/ms) was developed and validated for simultaneous quantification ic87114, roflumilast (rfm), and its active metabolite roflumilast n-oxide (rfn) using tolbutamide as an internal standard. the analytes were extracted by using liquid-liquid extraction and separated on a reverse phase c(18) column (50 mm × 3 mm i.d., 4.6 µ) using methanol: 2 mm ammonium acetate buffer, ph 4.0 as mobile phase at a flow rate 1 ml/ ...201223280750
screening for cardiovascular disease risk factors at baseline and post intervention among adults with intellectual disabilities in an urbanised asian society.background: adults with intellectual disabilities (id) face significant barriers to screening participation. we determined predictors for regular cardiovascular health screening at baseline among adults with id in singapore, and evaluated the effectiveness of a 3-month screening intervention. methods: the study population involved all adults with id aged ≥40 years receiving services from the movement for the intellectually disabled of singapore (minds), the largest such provider in singapore. ov ...201223279280
high readmission rates are associated with a significant economic burden and poor outcome in patients with grade iii/iv acute gvhd.graft-versus-host disease (gvhd) is a common complication following haematopoietic stem cell transplant but little is published about the impact of this condition on hospital readmission rates. we report a retrospective analysis of readmission rates and associated costs in 187 consecutive allogeneic transplant patients to assess the impact of gvhd. the overall readmission rate was higher in patients with gvhd (86% (101/118) vs. 59% (41/69), p < 0.001). the readmission rate was higher both in the ...201223278853
relationship between prenatal care and maternal complications in women with preeclampsia: implications for continuity and discontinuity of prenatal care.prenatal care is associated with better pregnancy outcome and may be a patient safety issue. however, no studies have investigated the types and quality of prenatal care provided in northern taiwan. this retrospective study assessed whether the hospital-based continuous prenatal care model at tertiary hospitals reduced the risk of perinatal morbidity and maternal complications in pre-eclampsia patients.201223276561
approaching zero: temporal effects of a restrictive antibiotic policy on hospital-acquired clostridium difficile, extended-spectrum β-lactamase-producing coliforms and meticillin-resistant staphylococcus aureus.a restrictive antibiotic policy banning routine use of ceftriaxone and ciprofloxacin was implemented in a 450-bed district general hospital following an educational campaign. monthly consumption of nine antibiotics was monitored in defined daily doses (ddds) per 1000 patient-occupied bed-days (1000 pt-bds) 9 months before until 16 months after policy introduction. hospital-acquired clostridium difficile, meticillin-resistant staphylococcus aureus (mrsa) and extended-spectrum β-lactamase (esbl)-p ...201223276500
proteomic analysis of different period excretory secretory products from clonorchis sinensis adult worms: molecular characterization, immunolocalization, and serological reactivity of two excretory secretory antigens-methionine aminopeptidase 2 and acid phosphatase.the excretory secretory products (esp) of clonorchis sinensis are the causative agents of clonorchiasis and biliary diseases. the parasites' esp play important roles in host-parasite interactions. the protein compositions of esp at different secretory times are different and have not been systemically investigated so far. in this study, we collected esp from six different periods (0-3 h, 3-6 h, 6-12 h, 12-24 h, 24-36 h, and 36-48 h) from c. sinensis adults. using a shotgun lc-ms/ms analysis, we ...201223274491
patients with metabolic syndrome and widespread high grade prostatic intraepithelial neoplasia are at a higher risk factor of prostate cancer on re-biopsy: a prospective single cohort study.objectives: to test the hypothesis that patients with widespread high grade prostatic intra epithelial neoplasia (whgpin) and metabolic syndrome (mets) are at a higher risk of prostate cancer (pca) at a repeat biopsy. methods and materials: we prospectively evaluated 161 patients submitted from december 2004 to december 2011 to prostate rebiopsy after a initial diagnosis of hgpin in a tertiary academic center. a 12 core biopsy template was used for all the biopsies. rebiopsy was performed six mo ...201223273912
sequential organ failure assessment score can predict mortality in patients with paraquat intoxication.paraquat poisoning is characterized by multi-organ failure and pulmonary fibrosis with respiratory failure, resulting in high mortality and morbidity. the objective of this study was to identify predictors of mortality in cases of paraquat poisoning. furthermore, we sought to determine the association between these parameters.201223272154
clinical signs to identify late-onset sepsis in preterm infants.late-onset neonatal sepsis (los) in preterm infants is an important cause of morbidity and mortality in preterm infants. since presenting symptoms may be non-specific and subtle, early and correct diagnosis is challenging. we aimed to develop a nomogram based on clinical signs, to assess the likelihood of los in preterms with suspected infection without the use of laboratory investigations. we performed a prospective cohort study in 142 preterm infants <34 weeks admitted to the neonatal intensiv ...201223271492
bacterial and viral interactions within the nasopharynx contribute to the risk of acute otitis media.to understand relationships between microbes in pathogenesis of acute otitis media during respiratory tract infections, we compared nasopharyngeal bacteria and respiratory viruses in symptomatic children with and without aom.201223266462
physiological responses of xenopus laevis tadpoles exposed to cyanobacterial biomass containing microcystin-lr.cyanobacteria are the primary biomass producers and some species synthesize remarkable amounts of secondary metabolites, the so-called cyanotoxins. several reports deal with the most common cyanotoxins, microcystins (mcs), and their effects on fishes but only a few studies investigated a natural exposure to mcs and limited information is available concerning the further aquatic vertebrate class, amphibians. in the present study, xenopus laevis tadpoles at stage 52 (nieuwkoop and faber, 1994) wer ...201223266398
polymerase chain reaction detection of human host preference and plasmodium parasite infections in field collected potential malaria vectors.this study was carried out to determine the human host preference and presence of plasmodium parasite in field collected anopheles mosquitoes among four villages around a military cantonment located in malaria endemic sonitpur district of assam, india. encountered malaria vector mosquitoes were identified and tested for host preference and plasmodium presence using pcr method. human host preference was detected using simple pcr, whereas vectorial status for plasmodium parasite was confirmed usin ...201223265376
dual-source 128-slice mdct neck: radiation dose and image quality estimation of three different protocols.to estimate the radiation dose and image quality of single-source (ssct), high-pitch (hpct), and dual-energy (dect) protocols of a dual-source ct (dsct) system for the examination of neck.201223265177
transcriptional changes in the transition from vegetative cells to asexual development in the model fungus aspergillus nidulans.morphogenesis encompasses programmed changes in gene expression that lead to the development of specialized cell types. in the model fungus aspergillus nidulans, asexual development involves the formation of characteristic cell types, collectively known as the conidiophore. with the aim of determining the transcriptional changes that occur upon induction of asexual development, we have applied massive mrna sequencing to compare the expression pattern of 19-h-old submerged vegetative cells (hypha ...201223264642
preoperative predictors of pathologic stage t2a and pathologic gleason score ≤ 6 in men with clinical low-risk prostate cancer treated with radical prostatectomy: reference for active surveillance.to assess preoperative parameters that may be predictive of pathologic stage t2a (pt2a) and pathologic gleason score (pgs) ≤ 6 disease in low-risk prostate cancer patients considering active surveillance. a cohort of 1,495 men with low-risk prostate cancer between 1993 and 2009 was utilized. preoperative assessment focused on patient age, race, diagnostic psa level, clinical stage, diagnostic biopsy gleason score, and prostate cancer laterality. kaplan-meier curves and a cox regression model wer ...201223263824
preparation and hydrolytic erosion of differently structured plga nanoparticles with chitosan modification.two types of poly-lactic-co-glycolic acid (plga) based nanoparticles were prepared by surface modification (c-nps) and homogeneous modification (g-nps) with chitosan. the naked plga nps were served as control. these nanoparticles all showed regularly spherical shape with mean diameters as 191.3 ± 3.6 nm, 211.9 ± 13.2 nm and 187.5 ± 17.6 nm for plga nps, c-nps and g-nps, respectively. their zeta potentials were -22.4 ± 1.31 mv, -8.7 ± 0.45 mv, -3.1 ± 0.12 mv, respectively. both c-nps (15.3% plga ...201223262384
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