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grover's disease associated with sarcoptes scabiei.an 83-year-old man presented with a 4-month history of discrete, itchy papules mainly distributed on the trunk and upper extremities. histopathologic examination of two biopsies from lesions on the trunk revealed mainly focal suprabasal acantholysis and an inflammatory infiltrate composed mainly of lymphocytes with a few eosinophils. the overall clinical and histopathologic features were consistent with grover's disease. however, scrapings taken from the skin lesions showed numerous mites of sar ...200111385234
paramyosin from the parasitic mite sarcoptes scabiei: cdna cloning and heterologous expression.the burrowing mite sarcoptes scabiei is the causative agent of the highly contagious disease sarcoptic mange or scabies. so far, there is no in vitro propagation system for s. scabiei available, and mites used for various purposes must be isolated from infected hosts. lack of parasite-derived material has limited the possibilities to study several aspects of scabies, including pathogenesis and immunity. it has also hampered the development of high performance serological assays. we have now cons ...200111393829
[why can scabies be of norwegian origin?]. 200111510251
preventing transmission of sarcoptes scabiei var. suis from infested sows to nursing piglets by a prefarrowing treatment with doramectin injectable solution.studies were conducted at swine facilities in illinois and north carolina to evaluate the effect of treatment with doramectin injectable solution on transmission prevention of sarcoptes scabiei var. suis from sows to nursing piglets. approximately 42 days prefarrowing, 58 mange-free sows were experimentally infested with 200 s. scabiei in each ear. seven to fourteen days prior to farrowing, 22 sows were given doramectin injectable intramuscularly at a dose of 300 microg/kg of body weight. a tota ...200111511419
concurrent sarcoptic and chorioptic acariosis in a british llama (lama glama). 200111548959
sarcoptes scabiei infestation among children in a displacement camp in sierra leone.the prevalence of scabies was investigated among a study population of 125 children between the ages of 1-15 y. confirmation of scabies was done by clinical examination of each child and by the identification of the mite by microscopically examining the scrapings from the scabies-like lesions. the prevalence was age dependent, with children under five years accounting for 77%, peaking to 86% among the 5 to 9-y-olds, and steadily declining with an increase in age. lesions were found on almost all ...200111429717
effect of season on the productivity of camels (camelus dromedarius and the prevalence of their major parasites in eastern ethiopia.the productivity and the prevalence rates of the major parasites of camels (camelus dromedarius) kept under traditional management conditions at errer valley, ethiopia were assessed for a year (october 1997-september 1998). the daily milk offtake was significantly higher (p < 0.05) during the wet season (3.12 +/- 0.03 l) than during the dry season (1.49 +/- 0.04 l). likewise, significantly higher (p < 0.05) daily weight gains (50.68 +/- 0.54 g) were observed during the wet season than during dry ...200111474866
ivermectin and clorsulon (ivomec super) in treatment of goats naturally infested with scab mites and biting lice.five goats naturally infested with sarcoptes scabiei, psoroptes ovis and bovicola caprae were treated with a combination of ivermectin and clorsulon. a subcutaneous injection in a dose of 1 ml/50 kg live weight was given. this provides dose levels of 200 ug ivermectin and 2 mg clorsulon. four goats were cured from the three ectoparasites within one to two weeks. the last elder goat, which was anaemic and naturally infected with trichostrongylus colubriformis, was still infested with the two scab ...200111478437
characterization of house dust mite and scabies mite allergens by use of canine serum antibodies.to identify the major allergenic proteins from the 3 main species of dust mites to which dogs react (dermatophagoides farinae, d. pteronyssinus, and euroglyphus maynei) and evaluate the potential cross-reactivity of dust mite allergens with antigens from the ectoparasitic mite sarcoptes scabiei var canis.200111560257
efficacy of moxidectin 1% injectable against natural infection of sarcoptes scabiei in sheep.thirty ewes naturally infected with sarcoptes scabiei var. ovis, were allocated into three groups of 10 animals each. animals in groups b and c were treated on day 0 and on days 0 and +10, respectively, with moxidectin 1% injectable at a dose of 0.2mg moxidectin/kg body weight (bw). group a remained untreated. seven days before treatment, the geometric mean of sarcoptes scabiei var. ovis per square centimeter of skin in groups a, b and c were not significantly different. from the day of treatmen ...200111705660
nodular scabies detected by computed dermatoscopy. 200111586026
[francesco redi and the birth of experimental parasitology].francesco redi (1626-1697) born in arezzo (tuscany, italy), an encyclopedic mind simultaneously naturalist, physician and poet is the founder of scientific and experimental parasitology by his works published in 1668 and 1684. in the first he showed the impossibility of spontaneous generation of insects (flies) and in the second are described over hundred species of parasites (helminths, mites, insects) from vertebrates and invertebrates with excellent illustrations. he has also recommended vari ...199711625103
[parasites--tiny but unpleasant companions at home and in the daycare]. 200011764453
[the remarkable debate during the beginning of the nineteenth century concerning the aetiology of scabies].the scabies mite (acarus or sarcoptes scabiei) was known already to aristoteles, to the arabic medicine during the early and to european physicians as well as laymen during the later middle ages, depicted in 1687 by bonomo in italy and by schwiebe in germany during the beginning of the eighteenth century. later in the middle of the century three pupils to linnaeus in their doctor's theses stated that the scabies mite (acarus humanus subcutaneus) was the cause of scabies. the best pictures of the ...199411640410
hyperkeratotic mange caused by sarcoptes scabiei (acariformes: sarcoptidae) in juvenile human-habituated mountain gorillas (gorilla gorilla beringei).to facilitate ecotourism and behavioral research, free-ranging mountain gorillas (gorilla gorilla beringei) have been habituated to humans. during routine health monitoring, five juvenile gorillas were observed with active crusted dermatitis and alopecia. papular and vesicular lesions and crusts with papular eruption and oozing were numerous and disseminated over the body of one gorilla with a confirmed infestation of scabies. in this gorilla, the hyperkeratotic crusts were loose and thick with ...200111763433
notoedric and sarcoptic mange in free-ranging lynx from switzerland.between march and december 1999, five free-ranging lynx (lynx lynx) affected by mange were found dead or shot by game wardens in the swiss alps. in the first two cases, notoedres cati was isolated from the skin; in the third and fourth case, sarcoptes scabiei was the cause of the infection; and in the fifth case, a mixed infection was diagnosed. red foxes (vulpes vulpes) affected with sarcoptic mange and domestic cats infested with n. cati are likely to be the sources of infection. it seems impr ...200211838224
experimental ivermectin treatment of sarcoptic mange and establishment of a mange-free population of spanish ibex.ivermectin was used to treat sarcoptic mange in spanish ibex (capra pyrenaica hispanica). its therapeutic effectiveness was analyzed when it was administered through subcutaneous injection, to sick animals in the consolidation stage of mange (third phase) and, with double injections to chronically affected animals (fourth phase) at a dosage of 0.2 or 0.4 mg/kg body weight (bw). three wk after treatment, the animals in the third phase of mange treated with a high dose (0.4 mg/kg bw) of ivermectin ...200111763741
the scourge of scabies.scabies ('itch mite') is truly a great neglected disease that inflicts misery on millions. molecular approaches, while still in their infancy, are providing a better understanding of the parasite and will have important implications for control and prevention. it has long been thought that dogs may act as a reservoir for human infections. however, genetic studies cast doubt over this supposition.200211852281
scabies in free-ranging mountain gorillas (gorilla beringei beringei) in bwindi impenetrable national park, uganda.between august and december 1996, there was an outbreak of a debilitating skin disease attributed to sarcoptes scabiei infection in mountain gorillas (gorilla beningei beringei) in bwindi impenetrable national park in uganda. all four members of a gorilla group which had been habituated to tourists were clinically affected; the infant male gorilla was most severely affected and died, the juvenile male showed serious manifestations of the disease and the two adult animals showed milder signs. the ...200211817857
diagnosis and treatment of scabies: a practical guide.scabies is a common, highly pruritic infestation of the skin caused by sarcoptes scabiei var. hominis. it is a very contagious parasitosis with specific lesions, such as burrows, and nonspecific lesions, such as papules, vesicles and excoriations. the typical areas of the body it affects are finger webs, wrists, axillary folds, abdomen, buttocks, inframammary folds and, in men, the genitalia. it is characterized by intense nocturnal pruritus. scabies is spread through close personal contact (rel ...200211817965
evaluation of an enzyme-linked immunosorbent assay (elisa) for the serological diagnosis of sarcoptic mange in dogs.canine scabies is a challenging disease to diagnose because sarcoptic mites are hard to find on skin scrapings. the purpose of this study was to evaluate a serologic enzyme-linked immunosorbent assay (elisa) as an aid in the diagnosis of canine scabies. in addition, serum samples were obtained post treatment to determine the duration and persistence of circulating scabies antibodies after resolution of natural infection. nineteen dogs diagnosed with sarcoptic mange and 38 control dogs were teste ...200111844220
the mitochondrial 12s gene is a suitable marker of populations of sarcoptes scabiei from wombats, dogs and humans in australia.we sequenced part of the mitochondrial 12s ribosomal rna gene of 23 specimens of sarcoptes scabiei from eight wombats, one dog and three humans. twelve of the 326 nucleotide positions varied among these mites and there were nine haplotypes (sequences) that differed by 1-8 nucleotides. phylogenetic analyses indicated that these mites were from two lineages: (1) mites from wombats from victoria, australia, and mites from the humans and dog from the northern territory, australia (haplotypes 1-4, 9) ...200211999028
crusted (norwegian) scabies. 200211932093
sarcoptic manage in wildlife.sarcoptic manage caused by sarcoptes scabiei is responsible for epizootic disease in populations of wild canids in north america, europe and australia, wild cats in europe and africa, wild ungulates and wild boars in europe, wombats and koalas in australia, and great apes and various wild bovids in africa. although short-term mortality may appear devastating, in a self-sustaining population, mortality is non-compensatory and a mange epizootic generally does not affect long-term population dynami ...200211974622
what's causing that itch? 200212229103
[profuse scabies: kinetic curves of parasitologic cure with an association of benzyl benzoate and sulfiram].in vitro exposure to benzyl benzoate (25 p. 100) kills sarcoptes scabiei within three hours. the aim of our study was to determine in vivo elimination of sarcopte scabiei with a benzyl benzoate-sulfiram association.200211988682
diagnosis and treatment of scabies in 2002: rapid diagnosis and proper management limit the risk of spread.(1) scabies is due to a parasite, sarcoptes scabiei hominis, that colonises the human epidermis. it can affect people of all ages, regardless of their socioeconomic status. (2) common scabies in adults causes sometimes intense pruritus and skin lesions with a characteristic aspect and distribution. the lesions are often more extensive in children. (3) crusted (hyperkeratotic) scabies, a severe and highly contagious form, mainly occurs in immunocompromised patients. (4) scabies lesions are often ...200212378748
preventing transmission of sarcoptic mange from sows to their offspring by injection of ivermectin. effects on swine production.a blind and controlled field study was conducted on a pig farm in australia to evaluate the activity of 1% ivermectin solution when injected into pregnant sows that were naturally infested with mites. the study was designed to appreciate the tolerance of the product on sows (litter size, litter birth weights, litter weaning weights, pre-weaning mortality) and to show the effects of sarcoptic mange on the growth performances of their offspring. twenty sows were selected and ranked on day-10, prio ...200212446087
elimination of mange mites sarcoptes scabiei var. suis from two naturally infested danish sow herds using a single injection regime with doramectin.attempts to eliminate sarcoptes scabiei var. suis were made in 2 naturally infested sow herds, by intramuscular (i.m.) injection of doramectin (dectomax, pfizer, new york, usa). a single injection strategy was used. in one of the herds, the environment was treated with an acaricide following dry cleaning of floors, walls and equipment. in the second herd, no environmental treatment was performed. results were measured by skin lesion scoring, ear scrapings to show sarcoptes scabiei var. suis, and ...200212173505
sarcoptic mange in free-ranging pampas foxes in the gran chaco, bolivia.sarcoptes scabiei infestation was diagnosed in two freshly dead free-ranging pampas foxes (pseudalopex gymnocercus) in the gran chaco, bolivia. diagnosis was made based on histologic evaluation of skin biopsies and identification of the parasite from skin scrapings. characteristic gross lesions consistent with mange were noted in 19 of 94 observations of free-ranging pampas foxes in the region from december 1998 to january 2000. none of 16 crab-eating foxes (cerdocyon thous) observed during the ...200212238385
ribosomal and mitochondrial dna sequence variation in sarcoptes mites from different hosts and geographical regions.in order to investigate the extent of the genetic variation in the dna sequences of sarcoptes scabiei, mite populations collected on alpine chamois ( rupicapra rupicapra), pyrenean chamois ( rupicapra pyrenaica) and red fox ( vulpes vulpes) from different localities of italy and spain were studied. sequence analyses were carried out on the second internal transcribed spacer of the nuclear ribosomal dna and on the 16s mitochondrial rrna gene. its-2 sequences showed a higher degree of genetic poly ...200212122437
infantile scabies or langerhans cell histiocytosis? 200312461795
generation and characterization of cdna clones from sarcoptes scabiei var. hominis for an expressed sequence tag library: identification of homologues of house dust mite allergens.molecular studies on scabies, a disease of considerable human and veterinary significance, have been limited because of the difficulty of obtaining the causative organism sarcoptes scabiei, the "itch mite." we have used skin from the bedding of crusted scabies patients as a source of mites for the construction of libraries of cdnas from s. scabiei var. hominis in the bacteriophage lambda vector lambdazap express. sequences of 145 clones established that the libraries predominantly contain sequen ...200312556150
two types of scab mites infesting man and sheep in north sinai.man and sheep were examined for scab mites infestations. two types of mites were recovered, sarcoptes scabiei and psoroptes ovis. in sheep, 197 out of 939 (20.98%) were infested with s. scabiei (4.05%) and p. ovis (16.93%). the highly infested sheep were recorded in el hassanah (28.22%) and the least infested ones were in al arish (15.85%). in man, 69 out of 790 (8.7%) were infested with s. scabiei (8.1%) and p. ovis (0.63%). the highly infested patients were recorded in el hassanah (16.2%) foll ...200112557944
atypical crusted scabies in an iranian man.crusted scabies has been defined as a scabies-induced psoriasiform dermatosis on the hands and feet with dystrophy of the nails and an erythematous scaling eruption that may be generalized. this case report demonstrates a patient who presented with widespread psoriasiform plaques that were teeming with scabies mites and eggs, but who had absence of nail and palmar involvement. while patients with crusted scabies may have nail dystrophy and involvement of the palms, this involvement is not necess ...200212546772
identification of a homologue of a house dust mite allergen in a cdna library from sarcoptes scabiei var hominis and evaluation of its vaccine potential in a rabbit/s. scabiei var. canis model.sarcoptes scabiei ("itch mite") causes scabies, a disease of considerable human and veterinary significance. little work has been done at the molecular level because of the difficulty of obtaining mites. we have used mites in skin from the bedding of crusted scabies patients for the construction of a library of 10(5) cdnas from s. scabiei var. hominis cloned in the vector pgex4t-2. we describe the isolation by immunoscreening of 2 clones, one of which (ssagl) is homologous to and cross-reactive ...200312556149
the effect of ivomec super on dogs experimentally infested with sarcoptes scabiei isolated from a patient.scabies infestation is a community health problem worldwide. this is particularly true in overcrowded and unhygienic areas. seven dogs were experimentally infested with sarcoptes scabiei freshly recovered from a patient. the dogs after infestation were treated with a mixture of ivermectin and clorsulon (ivomec super). the dose given to a single dog was 1 ml/50 kg body weight. this is equivalent to 200 mcg ivermectin and 2 mg clorsulon per kg body weight. five of the dogs (71.43%) were completely ...200112557931
sarcoptic mange (sarcoptes scabiei var vulpes) in a red fox (vulpes vulpes) population in north-west surrey. 200312572941
atopy patch test reactivity to house dust mites in patients with scabies. 200312653928
normalization of a cdna library cloned in lambda zap by a long pcr and cdna reassociation procedure. 200312613245
sarcoptic mange in foxes. 200312622292
clinical response of captive common wombats (vombatus ursinus) infected with sarcoptes scabiei var. wombati.seven common wombats (vombatus ursinus) were exposed and two of these were re-exposed to sarcoptes scabiei var. wombati (acari: sarcoptidae). for wombats exposed for the first time, five exposed to 5,000 mites on their shoulder developed moderate to severe parakeratotic mange after 11 wk compared with two given 1,000 mites that developed mild clinical signs of mange after 11 wk. for re-exposed wombats, one of two given 5,000 mites developed mild parakeratotic mange and the other developed severe ...200312685082
cellular response in the dermis of common wombats (vombatus ursinus) infected with sarcoptes scabiei var. wombati.the cellular response in the dermis of common wombats (vombatus ursinus) with sarcoptic mange exhibited some typical aspects of an immune response to sarcoptes scabiei. there was an induction phase for wombats experimentally infected with s. scabiei represented by absence of a dermal inflammatory infiltrate for at least 12 days after infection. t lymphocytes, plasma cells, mast cells, and neutrophils then entered the dermis, consistent with a type iv (delayed) hypersensitivity response. in free- ...200312685083
[scabies]. 200312722296
sarcoptic mange in foxes. 200312622293
pediatric scabies.scabies is an intensely pruritic dermatosis that is caused by a mite, sarcoptes scabiei var hominis. scabies is highly contagious and may have the pathognomonic sign of burrows in addition to erythematous papules. these lesions are often excoriated. in addition to classic scabies, special forms with distinctive clinical features exist. a variety of topical medications are available to treat the infestation.200312661745
current treatments for scabies.scabies is a frequent interhuman ectoparasitic infection. several treatments are available worldwide. there are local treatments: synthetic pyrethrins, benzyl benzoate, lindane, crotamiton. recently a few studies were published concerning ivermectin, systemic antiparasitic agent use in onchocercosis treatment. we reviewed the literature with an evidence-based medicine method. we attempt to answer two questions in particular: what is the treatment of choice for common scabies in a patient otherwi ...200312667233
detection of antibodies in sera of weaned pigs after contact infection with sarcoptes scabiei var. suis and after treatment with an antiparasitic agent by three different indirect elisas.three commercial enzyme-linked immunosorbent assays (elisas) were compared for the detection of antibodies to sarcoptes scabiei var. suis using experimental sera of six 8-week-old pigs after contact infection with sarcoptes scabiei var. suis. six non-infected pigs were monitored as a control group. blood sera were taken once a week from all animals. after successful infection the pigs were treated with an antiparasitic agent (12 weeks post infection (p.i.)) and the antibody titres were monitored ...200312732467
eucalyptus globulus (camphor oil) against the zoonotic scabies, sarcoptes scabiei.in egypt, scarcoptes scabiei is the most prevalence mites of medical importance infesting man. this is true in overcrowded and poorly hygienic areas. many effective acaridical regimens are available, but being compounds used as insecticides. with the success of camphor oil in treated human demodicidosis, it was applied for treating human scabies. camphor oil with or without glycerol dilutions gave complete cure, with concentrations (100%, 75% and 50%) within five to ten days.200312739800
productivity effects of bovine mange and control with ivermectin.a randomised block design study was conducted to evaluate the effects of mange on cattle. twenty-four simmentaler fleckvieh bulls were formed into eight replicates of three bulls based on day -56 body weight (288-414 kg). within replicates bulls were randomly allocated to groups g1: uninfested control, g2: infested control or g3: infested, treated with 0.2mg ivermectin/kg (1% ivermectin injection; ivomec, merial) on day 0. the g2 and g3 bulls were infested with sarcoptes/chorioptes mites on days ...200312809753
ectoparasitic infestations in homeless children.most human ectoparasites live on the surface of their host and depend on that host to complete their life cycle. the most common ectoparasitic infestations of medical importance in humans include pediculosis, scabies, myiasis, and tungiasis. different host factors are related, with increased risk of acquiring ectoparasitic infestation occurring among the homeless. although these ectoparasitic infections can be found worldwide, their prevalence is affected significantly by environmental condition ...200312748918
oral ivermectin treatment in two cases of scabies: effective in crusted scabies induced by corticosteroid but ineffective in nail scabies.we report two cases of scabies treated with oral ivermectin (200 micro g/kg). case 1, a 72-year-old man, developed crusted scabies with the use of oral corticosteroids due to a misdiagnosis by an earlier physician. the patient was successfully treated with two doses of oral ivermectin at a 7 day interval with concomitant topical use of crotamiton and keratolytic agents. however, the nail scabies in this patient failed to respond to these treatments. live mites were detected from all his toenails ...200312773808
pyoderma and scabies: a benign association? 200312734437
what's eating you? canine scabies.infestation with sarcoptes scabiei var canis, the causative strain of canine scabies, can produce a pruritic rash in humans. the rash generally manifests within 24 to 96 hours of contact with the affected pet. scrapings are generally negative, and the correct diagnosis requires a high index of suspicion.200312953932
expressed sequence tag analysis of sarcoptes scabiei.sarcoptes scabiei is an important parasitic mite in both man and animals. little is known about the molecular interactions between this pathogen and its host. this is in part explained by the paucity of mite-derived material, including antigens. to extend the knowledge of the molecular repertoire in s. scabiei, we have performed a gene survey by an expressed sequence tag (est) analysis. a total of 1020 ests were generated from an s. scabiei cdna library. the average sequence read was 510 bp afte ...200312954015
clinical pearls: a 37-year-old man with a rash... 200312837652
[existence of sarcoptes scabiei varietas scabiei crustosae; acarid morphology]. 195313086690
sarcoptic mange in the human. a report of an epidemic of 10 cases of infection by sarcoptes scabiei, variety canis. 196113890083
a note on the effects on the growth of tumors of a combined treatment with chlorpromazine and a "mitotic poison". 196313963456
granuloma annulare induced by scabies. 200312926818
ectoparasite infestations of red foxes (vulpes vulpes) in hungary.a survey was carried out to investigate the ectoparasite infestations of 100 red foxes (vulpes vulpes) in hungary. the overall prevalence of flea and tick infestation was high (62 and 86% with the dominance of the anthropophil pulex irritans and ixodes ricinus), but the number of parasites was low to moderate. felicola vulpis was not found in the present study, and the prevalence of otodectes cynotis was only 2%. based on prevalence (21%), mange lesion scores, and the negative correlation betwee ...200312944049
efficacy of ivermectin against sarcoptes scabiei var suis in pigs. 200312974341
treatment of sarcoptic, psoroptic and chorioptic mange in a belgian alpaca herd. 200314516117
safety and efficacy against mange and nematodes of three formulations of abamectin in arabian camels. 200314627239
the origin of sarcoptes scabiei in wombats.in 2002, skerratt et al. phylogenetically analysed sequence data for several haplotypes of the parasitic mite sarcoptes scabiei from wombat, human and dog hosts in australia, to test scenarios concerning the origin and diversification of the scabies infections in wombats. here we note that their substantive conclusions can be called into question by the choice of model used in their phylogenetic analysis, the lack of a root for their phylogenetic trees, and their interpretation of the evolutiona ...200314530970
modulation of cytokine expression in human keratinocytes and fibroblasts by extracts of scabies mites.sarcoptes scabiei lives in the stratum corneum of its mammalian host. keratinocytes and fibroblasts are among the first cells to encounter the burrowing mite and its products. the aim of this study was to determine if molecules in an extract of s. scabiei modulate the expression of cytokines by keratinocytes and fibroblasts. human keratinocytes and fibroblasts were exposed to an extract of s. scabiei var. canis in the absence or presence of escherichia coli lipopolysaccharide. cytokine expressio ...200314740884
bullous scabies mimicking bullous pemphigoid.scabies is an infestation caused by sarcoptes scabiei and characterised by polymorphous lesions that may include burrows, papules, nodules, excoriation and crusts. vesicular and bullous lesions are rather rare. several diseases may be confused with scabies. we report a case of bullous scabies which, on the basis of the clinical and histopathological picture, mimicked bullous pemphigoid. direct and indirect immunofluorescence were negative. bullae recurred and persisted despite systemic corticost ...200314578561
nosocomial outbreak of scabies in a hospital in spain.an outbreak of scabies occurred in a ward of a local hospital in barbastro (huesca, spain), between november 2002 and january 2003. the outbreak was linked to a patient infested with mites when he was admitted to the ward on 1 november 2002. the first case had onset of symptoms on 5 november and the last one on 5 january 2003. seventeen cases were reported: 11 healthcare workers (hcws) and six patients. the outbreak was attributed to a delay in diagnosis, and lack of individual protection measur ...200314605375
mechanisms for a novel immune evasion strategy in the scabies mite sarcoptes scabiei: a multigene family of inactivated serine proteases.parasitic infestation of the skin by the mite sarcoptes scabiei is a significant problem worldwide, particularly in socially disadvantaged communities. a multigene family of at least 24 homologs of a serine protease allergen have been identified in s. scabiei. surprisingly, the products of all but one of these genes are predicted to be catalytically inactive, due to mutations at a critical triad of amino acids at the active site. we discuss the possibility that these genes for inactivated protea ...200314675192
extracts of scabies mites (sarcoptidae: sarcoptes scabiei) modulate cytokine expression by human peripheral blood mononuclear cells and dendritic cells.we performed a series of experiments to determine if human peripheral blood mononuclear cells (pbmcs) from a healthy donor and dendritic cells (nhdcs) derived from these pbmcs reacted to molecules in a scabies extract. pbmcs extravasate from the circulatory system and enter tissues such as scabietic lesions, where monocytes become macrophages. cells were cultured in medium alone or medium containing 50 microg/ml of sarcoptes scabiei (ss) extract, 50 ng/ml e. coli lipopolysaccharide (lps), or ss ...200414989348
circulating ige in patients with ordinary and crusted scabies.serum from seven patients with ordinary scabies and six with crusted scabies were screened by immunoblotting for ige- and igg-specific proteins in an extract of the mite, sarcoptes scabiei variety canis. sera from atopic individuals without sensitivity to house dust mites were used as controls. serum from all of the patients with crusted scabies showed strong ige binding to 11-21 and igg binding to 1-7 scabies proteins. in contrast, three of the seven patients with ordinary scabies showed ige bi ...200414989349
[possibilities of transmission of sarcoptes scabiei]. 195114835514
[generic specificity of sarcoptes scabiei (latr.) var. canis]. 195114836989
sarcoptes scabiei infestation misdiagnosed and treated as langerhans cell histiocytosis.the inflammatory cell infiltrate in sarcoptes scabiei infestations often includes langerhans cells. scabies infestations in children may mimic langerhans cell histiocytosis (lch) clinically as well. we report two children with scabies who were misdiagnosed clinically and histologically as lch and treated with systemic chemotherapy. scabies must always be ruled out in infants and children with eczematous eruptions and inflammatory infiltrates that include histiocytes on histologic examination.200414871329
ectoparasites--the underestimated realm.context: ectoparasitoses (infestations with parasites that live on or in the skin) can cause considerable morbidity. whereas pediculosis and scabies are ubiquitous, cutaneous larva migrans and tungiasis (sand-flea disease) occur mainly in hot climates. the prevalence of ectoparasitoses in the general population is usually low, but can be high in vulnerable groups. scientific knowledge on how to deal best with parasitic skin diseases in different settings is scanty, and evidence-based measures fo ...200415032237
dermoscopy for the in vivo detection of sarcoptes scabiei.we report the case of an 80-year-old patient who had intense pruritus which did not respond to a 3-month treatment with topical corticosteroids. on dermoscopy examination of the excoriations, we found the typical dermoscopic aspect of the scabies mite at a distance. dermoscopy allows identifying a triangular structure which corresponds to the anterior section of the mite including the mouth part and the 2 pairs of front legs. this aspect has been described as resembling a jetliner with its trail ...200415118379
images in clinical medicine. sarcoptes scabiei infestation. 200415163791
a multigene family of inactivated cysteine proteases in sarcoptes scabiei. 200415191567
proliferation of protease-enriched mast cells in sarcoptic skin lesions of raccoon dogs.skin sites, tongue, lung, liver, jejunum and rectum from two raccoon dogs with sarcoptes scabiei infestation and five normal (control) raccoon dogs were examined in terms of the distribution, proteoglycan properties and protease activity of mast cells. infestation with s. scabiei caused a significant increase in the number of dermal mast cells. while the number of mast cells (average +/- standard deviation) in specimens of skin from the dorsum, dorsal neck, dorsal hind foot and dorsal fore foot ...200415144797
acaricidal activity of melaleuca alternifolia (tea tree) oil: in vitro sensitivity of sarcoptes scabiei var hominis to terpinen-4-ol.to compare the acaricidal activity of melaleuca alternifolia (tea tree) oil (tto) and some of its individual active components on the itch mite sarcoptes scabiei var hominis.200415148100
scabies: more than just an irritation.human scabies, caused by skin infestation with the arthropod mite, sarcoptes scabiei, typically results in a papular, intensely pruritic eruption involving the interdigital spaces, and flexure creases. recent research has led to a reassessment of the morbidity attributable to this parasite in endemic communities, particularly resulting from secondary skin sepsis and postinfective complications including glomerulonephritis. this has led to studies of the benefits of community based control progra ...200415254301
genetic epidemiology of sarcoptes scabiei (acari: sarcoptidae) in northern australia.utilising three hypervariable microsatellite markers we have previously shown that scabies mites on people are genetically distinct from those on dogs in sympatric populations in northern australia. this had important ramifications on the formulation of public health control policies. in contrast phylogenetic analyses using mitochondrial markers on scabies mites infecting multiple animal hosts elsewhere in the world could not differentiate any genetic variation between mite haplotype and host sp ...200415157767
first documentation of in vivo and in vitro ivermectin resistance in sarcoptes scabiei.ivermectin is increasingly being used to treat scabies, especially crusted (norwegian) scabies. however, treatment failures, recrudescence, and reinfection can occur, even after multiple doses. ivermectin resistance has been documented for some intestinal helminths in animals with intensive ivermectin exposure. ivermectin resistance has also been induced in arthropods in laboratory experiments but, to date, has not been documented among arthropods in nature. we report clinical and in vitro evide ...200415206075
skewed th1/th2 immune response to sarcoptes scabiei.scabies is a contagious skin disease of humans and many other species of mammals. previous studies suggested that the balance between the th1 and th2 immune responses may influence the outcome of a scabies infestation in a sensitized host. therefore, in this study, we examined the t-helper cell cytokine profiles of splenocytes and lymph node cells in balb/c mice that were immunized with scabies extract (primary response), infested with scabies mites (primary response), or immunized and then infe ...200415357058
outbreak of sarcoptic mange and malasseziasis in rabbits (oryctolagus cuniculus).an outbreak of combined sarcoptes and malassezia spp. infection was diagnosed in a rabbitry. about 20 (4%) of 500 rabbits were affected. two 6- to 8-month-old female holland lops rabbits were submitted to the tifton diagnostic & investigational laboratory at the university of georgia for complete necropsy. gross lesions consisted of marked multifocal areas of alopecia, crusting, and dermatitis around the eye and on ears, nose, lips, neck, abdomen, feet, and external genitalia. histologic examina ...200415357325
the scybala (fecal pellets) of sacroptes scabiei var. hominis are obviously stained with chlorazol black e. 200415235198
history, biology and control of sheep scab.sheep scab is one of the oldest known diseases of sheep. it is caused by either of the mange mites psoroptes ovis (fig. 1 and cover) or sarcoptes scabiei. p. ovis causes irritation so intense that sheep become preoccupied with scratching, cease to feed and rapidly become emaciated. it should be eradicated on welfare grounds alone (fig. 2).198615462743
population effects of sarcoptic mange in barbary sheep (ammotragus lervia) from sierra espuña regional park, spain.the nonindigenous barbary sheep population (ammotragus lervia) of the sierra espuna regional park (murcia, spain) suffered an outbreak of sarcoptic mange between 1991 and 1995, which contributed to a population decrease of 86%. this study presents the results of two population surveys conducted in 1994 and 1999 based on the fixed point and itineraries method (fpi) and the excrement count (ec) method, as well as data from demographic estimates and clinical observations conducted by the regional a ...200415465713
rapid quantitative assay for acaricidal effects on sarcoptes scabiei var. suis and otodectes cynotis.brimer et al. (vet. parasitol. 51: 123-135, 1993 and 59: 249-255, 1995) developed a migration assay for acaricidal effect of acetylcholinesterase inhibitors and macrocyclic lactones utilising sarcoptes scabiei var. suis mites. in contrast to many others, this assay is fully quantitative but quite time-consuming. the aim of the present investigation was to modify this assay to become faster and simpler. as a result accurate determinations can now be obtained within 6h, as opposed to 24h. furtherm ...200415285140
biotin-avidin amplified elisa for detection of antibodies to sarcoptes scabiei in chamois (rupicapra spp.).scabies is a major threat to the well being of mountain-dwelling bovid hosts, rupicapra rupicapra and rupicapra pyrenaica. severe outbreaks are in progress over a significant part of their distribution area and resource managers demand improved methods to monitor, analyse and possibly forecast the spread and effects of scabies at the population level. an amplified capture enzyme-linked immunosorbent assay was developed to detect antibodies to sarcoptes scabiei in chamois (rupicapra spp.) serum. ...200415535959
on the substantial variation in serological responses in pigs to sarcoptes scabiei var. suis using different commercially available indirect enzyme-linked immunosorbent assays.two trials were carried out to compare the use of different enzyme-linked immunosorbent assays (elisas) for the detection of antibodies against sarcoptes scabiei var. suis. in the first trial, we employed four tests and 70 selected sera from a closed pig farm with sarcoptic mange. the sera were taken from the breeding area as well as from the finishing unit and compared with skin scrapings. the sarcoptes-elisa 2001 yielded the most positive results (88.58%), followed by the elisa of the national ...200415338288
outbreak of scabies in human beings, acquired from chamois (rupicapra rupicapra). 200415559427
sarcoptic mange in raccoons in michigan.sarcoptic mange is a cause of pruritic skin disease in domestic dogs and a wide range of wildlife species. we describe sarcoptic mange in free-ranging raccoons (procyon lotor). three adult raccoons from upper wayne county, michigan (usa), were captured, killed, and submitted for diagnostic evaluation. the animals were intensely pruritic, and two had advanced alopecic and crusting lesions over their dorsum and hind limbs. skin scrapings and skin biopsies revealed crusting and hyperkeratotic derma ...200415362840
scabies: new future for a neglected disease.scabies is a disease of global proportions in both human and animal populations, resulting from infestation of the skin with the "itch" mite sarcoptes scabiei. despite the availability of effective chemotherapy the intensely itching lesions engender significant morbidity primarily due to secondary sepsis and post-infective complications. some patients experience an extreme form of the disease, crusted scabies, in which many hundreds of mites may infest the skin causin severe crusting and hyperke ...200415504541
norwegian scabies in the immunocompromised patient.norwegian, or crusted, scabies can be defined as a generalized severe scabies (sarcoptes scabiei var. hominis) infestation usually affecting the immunocompromised patient that is most commonly seen with the leukemia-lymphoma group of neoplasms. the diagnosis is commonly missed, which can lead to mismanagement. we describe a patient with norwegian scabies involving the lower extremities. the patient circumstances and treatment, as well as a review of the literature, are presented. the diagnosis o ...200415547127
the effect of antimicrobial growth promoter withdrawal on the health of weaned pigs in finland.the use of the antimicrobial growth promoters (agps) carbadox and olaquindox has been banned in the european union (eu) since september 1999. we studied the effects of the withdrawal on the health of weaned piglets on two types of piglet-producing farms (farrowing herds and farrow-to-finish herds) from the different regions of finland. farms with no major problems with post-weaning diarrhoea were selected for the study to better evaluate the effect of agps alone. data on production, medication a ...200415579342
functional analysis and localisation of a delta-class glutathione s-transferase from sarcoptes scabiei.the mite sarcoptes scabiei causes sarcoptic mange, or scabies, a disease that affects both animals and humans worldwide. our interest in s. scabiei led us to further characterise a glutathione s-transferase. this multifunctional enzyme is a target for vaccine and drug development in several parasitic diseases. the s. scabiei glutathione s-transferase open reading frame reported here is 684 nucleotides long and yields a protein with a predicted molecular mass of 26 kda. through phylogenetic analy ...200415619514
prevalence, risk factors and economic importance of infestations with sarcoptes scabiei and haematopinus suis in sows of pig breeding farms in hesse, germany.a cross-sectional survey was performed in 110 randomly selected pig-breeding farms of southern hesse, germany to estimate the prevalence of ectoparasite infestations and to find possible risk factors. ear scrapings of, if available, 10 sows per farm were examined for sarcoptes scabiei var. suis (de geer) (acaridida: sarcoptidae) by the potassium hydroxide digestion method, and a total of 2754 sows was inspected for skin lesions and infestations with haematopinus suis (l.) (anoplurida: haematopin ...200415642002
ectoparasitic sexually transmitted diseases: scabies and pediculosis.scabies and pediculosis are diagnosed on an almost daily basis in many dermatology offices. whether the patient seeks medical attention because of the often unbearable itch of scabies or because of the fear of lice infestations, the physician should be on the lookout for these ectoparasitic infestations. secondary bacterial infection, resistance to medication, and the risk of spread of the infestations to family members and other close contacts may complicate the problem. patients frequently hav ...200415596323
analysis of sarcoptes scabiei finds no evidence of infection with wolbachia.the endosymbiont wolbachia has been detected in a range of filarial nematodes and parasitic mites and is known to affect host reproductive compatibility and potentially evolutionary processes. pcr of wolbachia surface protein (wsp), ftsz and 16srrna genes from individual sarcoptes scabiei mites obtained from a series of individual hosts, and database searches of an s. scabiei var. hominis est library failed to detect wolbachia genes. therefore, wolbachia appears not to be involved in the genetic ...200415710433
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