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screening of zulu medicinal plants for angiotensin converting enzyme (ace) inhibitors.twenty plants used by traditional healers in south africa for the treatment of high blood pressure were investigated for their anti-hypertensive properties, utilizing the angiotensin converting enzyme assay. a hit rate of 65% was achieved, with the highest inhibition (97%) obtained by adenopodia spicata leaves. a further seven plants exhibited an inhibition greater than 70% and five more over 50%. the leaves of the plants showed the greatest levels of inhibition. there was little difference in t ...199910624863
a comparative study of the antimicrobial and phytochemical properties between outdoor grown and micropropagated tulbaghia violacea harv. plants.the study aimed to compare the antimicrobial and phytochemical properties of in vitro cultured and outdoor grown tulbaghia violacea plants in the quest to validate the use of micropropagated plants as alternatives to outdoor grown plants in traditional medicine. tulbaghia violacea is used extensively in south african traditional medicine for hiv/aids patients and in the treatment of gastrointestinal ailments, asthma, fever and tuberculosis.201121291985
in vitro antimicrobial synergism within plant extract combinations from three south african medicinal bulbs.tulbaghia violacea, hypoxis hemerocallidea and merwilla plumbea are used in south african traditional medicine for the treatment of some infectious diseases and other ailments.201222075455
apoptotic potential role of agave palmeri and tulbaghia violacea extracts in cervical cancer cells.cervical cancer, a gynaecological malignant disorder, is a common cause of death in females in sub-saharan africa, striking nearly half a million of lives each year worldwide. currently, more than 50 % of all modern drugs in clinical use are of natural products, many of which have an ability to control cancer cells (madhuri and pandey, curr sci 96:779-783, 2009; richter, traditional medicines and traditional healers in south africa, 2003). in south africa, plants used to treat cancer are rare ev ...201424993114
cardiovascular effects of tulbaghia violacea harv. (alliaceae) root methanolic extract in dahl salt-sensitive (dss) rats.in african folk medicine, tulbaghia violacea harv.(alliaceae), a herbaceous plant also known by other common local names such as 'wild garlic', 'society garlic' and 'sweet garlic', has been used for the management, control and/or treatment of several human ailments; including hypertension. the aim of the present study was to investigate the cardiovascular effects of methanolic extract of tulbaghia violacea harv. in dahl salt-sensitive (dss) rats.201323291533
effect of tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive wistar rats.tulbaghia violacea harv. (alliaceae) is a small bulbous herb which belongs to the family alliaceae, most commonly associated with onions and garlic. in south africa, this herb has been traditionally used in the treatment of various ailments, including fever, colds, asthma, paralysis, hypertension and stomach problems. the aim of this study was to evaluate the effect of methanol leaf extracts (mle) of tulbaghia violacea on the blood pressure (bp) and heart rate (hr) in anaesthetized male spontane ...201222222281
some morphological aspects of the synaptonemal complex in higher plants.the synaptonemal complex is illustrated in electron micrographs from pollen mother cells (p.m.cs) of the following plants: fritillaria lanceolata, allium fistulosum, tulbaghia violacea, luzula purpurea, phaedranassa viridiflora and the tulip cultivar keiserkroon. the possibility that the lateral elements in synaptonemal complexes of plants are tubiform structures is discussed in relation to their fine structure and in the light of a deformity seen in them. an assessment of the evidence suggestin ...197716289
tulbaghia violacea harv. plant extract affects cell wall synthesis in aspergillus flavus.this study investigates the effect that aqueous extracts of tulbaghia violacea harv. harbouring plant saponins, phenolics and tannins have on aspergillus flavus β-(1,3) glucan and chitin synthesis.201728132403
the effect of tulbaghia violacea extracts on testosterone secretion by testicular cell cultures.this study aimed to determine the effect of tulbaghia violacea harv. on the male reproductive system in vitro by using testicular cell cultures. tulbaghia violacea is a plant species indigenous to southern africa and is used locally as a herbal remedy/medicine to treat several ailments.201020723589
interaction of lectin-like proteins of south african medicinal plants with staphylococcus aureus and bacillus subtilis.lectin-like proteins from seven medicinal plant species of south africa possessing well-documented antibacterial effects were examined for the interaction with two gram-positive bacterial pathogens staphylococcus aureus and bacillus subtilis. agglutinins elicited selective aggregation reactions with bacterial strains. hypoxis hemerocallidea and combretum mkhuzense agglutinins aggregated s. aureus at 4 and 5 microg ml(-1) of protein concentrations, respectively. b. subtilis was aggregated by c. m ...200212007702
micromonospora tulbaghiae sp. nov., isolated from the leaves of wild garlic, tulbaghia violacea.a novel actinomycete, strain tvu1(t), was isolated from leaves of the indigenous south african plant tulbaghia violacea. applying a polyphasic approach, the isolate was identified as a member of the genus micromonospora. phylogenetic analysis of the 16s rrna gene sequence showed that strain tvu1(t) was most closely related to micromonospora echinospora dsm 43816(t). however, phylogenetic analysis based on gyrb gene sequences showed that strain tvu1(t) was most closely related to the type strains ...201019667372
angiotensin i-converting enzyme inhibitor activity of nutritive plants in kwazulu-natal.traditional herbal remedies still form an integral part of south african culture, hence necessitating reports on the scientific rationale for their uses. organic and aqueous extracts from 16 nutritive plants found in kwazulu-natal, south africa were screened for angiotensin i-converting enzyme (ace) inhibitory activity using a fluorometric enzyme assay. a plant was considered to have potential antihypertensive properties if it inhibited the ace enzyme and thus the conversion of angiotensin i to ...200818598177
the value of plant extracts with antioxidant activity in attenuating coccidiosis in broiler chickens.coccidiosis remains one of the most important diseases in the poultry industry and results in the annual loss of millions of us dollars by the poultry industry. in south africa and other developing countries where a large percentage of the population is unemployed, cheap food production is necessary. if the control of the coccidian parasite could be made more economical, these savings could be passed on to the consumer. in europe, where the economics are different, people are becoming more aware ...200818417293
antioxidant, antidiabetic and hypolipidemic effects of tulbaghia violacea harv. (wild garlic) rhizome methanolic extract in a diabetic rat model.the prevalence of diabetes mellitus (dm) continues to rise alarmingly despite years of intensive research. the need to explore alternative remedies such as traditional phytotherapy has therefore become increasingly important in the management and treatment of dm.201526577219
aqueous extracts of tulbaghia violacea inhibit germination of aspergillus flavus and aspergillus parasiticus conidia.aspergillus flavus and aspergillus parasiticus are important plant pathogens and causal agents of pre- and postharvest rots of corn, peanuts, and tree nuts. these fungal pathogens cause significant crop losses and produce aflatoxins, which contaminate many food products and contribute to liver cancer worldwide. aqueous preparations of tulbaghia violacea (wild garlic) were antifungal and at 10 mg/ml resulted in sustained growth inhibition of greater than 50% for both a. flavus and a. parasiticus. ...201121669082
influence of nitrogen fertilizers on yield and antifungal bioactivity of tulbaghia violacea l.tulbaghia is known to have antifungal properties that can be used in the treatment of both human and plant pathogens and is used in traditional medicine in south africa. increasing demands for plant material makes it necessary to cultivate this species on a large scale. unfortunately, cultivation can lead to a reduction in the biological activity of plants making them unsuitable for use. in light of the lack of knowledge regarding the agronomic requirements of this plant, the aim of this study w ...200819244293
screening of traditionally used south african plants for antifungal activity against candida albicans.twenty-four south african medicinal plants were screened against candida albicans standard strain atcc 10231 and two clinical isolates from a 5-month-old baby and an adult, in an attempt to find a traditional remedy to treat oral candidiasis, which is prevalent in hiv-patients. allium sativum l. and tulbaghia violacea l. aqueous bulb extracts had mic values of 0.56 and 3.25mg/ml respectively, whilst polygala myrtifolia l. leaves and glycyrrhiza glabra l. rhizome extracts had mic values of 1.56 m ...200312738093
antidiabetic and cytotoxicity screening of five medicinal plants used by traditional african health practitioners in the nelson mandela metropole, south africa.diabetes mellitus is a growing problem in south africa and of concern to traditional african health practitioners in the nelson mandela metropole, because they experience a high incidence of diabetic cases in their practices. a collaborative research project with these practitioners focused on the screening of bulbine frutescens, ornithogalum longibracteatum, ruta graveolens, tarchonanthus camphoratus and tulbaghia violacea for antidiabetic and cytotoxic potential. in vitro glucose utilisation a ...201122238496
tulbaghia alliacea phytotherapy: a potential anti-infective remedy for candidiasis.the reproductive health of individuals is severely compromised by hiv infection, with candidiasis being the most prevalent oral complication in patients. although not usually associated with severe morbidity, oropharyngeal candidiasis can be clinically significant, as it can interfere with the administration of medications and adequate nutritional intake, and may spread to the esophagus. azole antifungal agents are commonly prescribed for the treatment and prophylaxis of candidal infections, how ...200616835880
the amino acid precursors and odor formation in society garlic (tulbaghia violacea harv.).identification and isolation of (r(s)r(c))-s-(methylthiomethyl)cysteine-4-oxide from rhizomes of tulbaghia violacea harv. is reported. the structure and absolute configuration of the amino acid have been determined by nmr, maldi-hrms, ir, and cd spectroscopy. its content varied in different parts of the plant (rhizomes, leaves, and stems) between 0.12 and 0.24 mg g(-1) fr. wt, being almost equal in the stems and rhizomes. in addition, s-methyl- and s-ethylcysteine derivatives have been detected ...200211985847
in vitro cytotoxic and pro-apoptotic effects of water extracts of tulbaghia violacea leaves and bulbs.infusions of tulbaghia violacea (wild garlic) in water are used in traditional medicine in southern africa to treat numerous diseases, including cancer. several studies have previously demonstrated the cytotoxic activities of extracts of t. violacea in cultured cancer cells. their findings support the potential anti-cancer properties of this plant. however, these studies made use of organic solvent extraction methods, while the traditional use of the plant involves the preparation of infusions i ...201525683299
allium species from central and southwest asia are rich sources of marasmin.marasmin, which is especially known from the two south african species tulbaghia alliacea and tulbaghia violacea , but was also described for the garlic mushroom marasmius alliaceus , is the precursor of the thiosulfinate marasmicin. marasmicin has attracted considerable attention because of its antifungal and tuberculostatic activities. however, many allium species of the subgenus melanocrommyum, especially allium suworowii , are also very rich in marasmin. a. suworowii revealed concentrations ...201121721585
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