Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| moisturizing and antiinflammatory properties of cosmetic formulations containing centella asiatica extract. | centella asiatica extract is a rich source of natural bioactive substances, triterpenoid saponins, flavonoids, phenolic acids, triterpenic steroids, amino acids and sugars. thus, many scavenging free radicals, exhibit antiinflammatory activity and affect on the stratum corneum hydration and epidermal barrier function. the aim of the present study was to evaluate the in vivo moisturizing and antiinflammatory properties of cosmetic formulations (oil-in-water emulsion cream and hydrogel) containing ... | 2017 | 27168678 |
| the ameliorating effect of centella asiatica ethanolic extract on albino rats treated with isoniazid. | isoniazid, also called isonicotinyl hydrazine (inh), is a commonly used drug for treating tuberculosis. the main drawback is its toxic side effects. centella asiatica has long been used in the ayurvedic system of medicine owing to its wide medicinal properties. this study was designed to examine the effectiveness of c. asiatica ethanolic leaf extract (ca) on inh-treated albino rats. | 2017 | 27701138 |
| effect of a mixture of diosmin, coumarin glycosides, and triterpenes on bleeding, thrombosis, and pain after stapled anopexy: a prospective, randomized, placebo-controlled clinical trial. | we evaluated the efficacy of oral administration of a mixture of diosmin, coumarin glycosides, and centella asiatica (venoplant®) in preventing bleeding, pain, and thrombosis of internal and external hemorrhoids after stapled anopexy (sa). | 2017 | 27815700 |
| synergistic combinations of five single drugs from centella asiatica for neuronal differentiation. | to identify alternatives of nerve growth factor, which could promote nf68 protein expression and contribute toward neuronal differentiation, five compounds namely: asiatic acid, madecassic, madecassoside, quercetin, and isoquercetin, obtained from centella asiatica, were examined for their neuronal differentiation effects on pc12 cells. c. asiatica has been applied as an effective herbal medicine for the treatment of various diseases, including depression. according to a statistical design of ex ... | 2017 | 27893605 |
| madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of th17 toward treg cells via the pparγ/ampk/acc1 pathway. | the imbalance between th17 and treg cells substantially contributes to the intestinal immune disturbance and subsequent tissue injury in ulcerative colitis. the triterpenoid-rich fraction of centella asiatica was able to ameliorate dextran sulfate sodium-induced colitis in mice. here we explored its active ingredient and underlying mechanism with a focus on restoring the th17/treg balance. the four main triterpenoids occurring in c. asiatica were shown to attenuate colitis in mice by oral admini ... | 2017 | 28358365 |
| anti-inflammatory effect of titrated extract of centella asiatica in phthalic anhydride-induced allergic dermatitis animal model. | centella asiatica has potent antioxidant and anti-inflammatory properties. however, its anti-dermatitic effect has not yet been reported. in this study, we investigated the anti-dermatitic effects of titrated extract of centella asiatica (teca) in a phthalic anhydride (pa)-induced atopic dermatitis (ad) animal model as well as in vitro model. an ad-like lesion was induced by the topical application of five percent pa to the dorsal skin or ear of hos:hr-1 mouse. after ad induction, 100 μl of 0.2% ... | 2017 | 28358324 |
| asiatic acid ameliorates pulmonary fibrosis induced by bleomycin (blm) via suppressing pro-fibrotic and inflammatory signaling pathways. | idiopathic pulmonary fibrosis is known as a life-threatening disease with high mortality and limited therapeutic strategies. in addition, the molecular mechanism by which pulmonary fibrosis developed is not fully understood. asiatic acid (aa) is a triterpenoid, isolated from centella asiatica, exhibiting efficient anti-inflammatory and anti-oxidative activities. in our study, we attempted to explore the effect of asiatic acid on bleomycin (blm)-induced pulmonary fibrosis in mice. the findings in ... | 2017 | 28320097 |
| centella asiatica attenuates aβ-induced neurodegenerative spine loss and dendritic simplification. | the medicinal plant centella asiatica has long been used to improve memory and cognitive function. we have previously shown that a water extract from the plant (caw) is neuroprotective against the deleterious cognitive effects of amyloid-β (aβ) exposure in a mouse model of alzheimer's disease, and improves learning and memory in healthy aged mice as well. this study explores the physiological underpinnings of those effects by examining how caw, as well as chemical compounds found within the extr ... | 2017 | 28279707 |
| ethnobotanical survey of herbal tea plants from the traditional markets in chaoshan, china. | herbal tea, which refers to "cooling tea", "cool beverage", or "liáng chá" in china, includes a range of drinks with heat-clearing and detoxification qualities. herbal tea plants are great contributive to the health and prosperity of chaoshan people. the aim of the study was to document herbal tea plant species used and commercialized as "liáng chá" in chaoshan area, to facilitate the use and development of herbal tea enterprises, and to promote the further development of national herbal tea. | 2017 | 28249822 |
| partial-thickness burn wounds healing by topical treatment: a randomized controlled comparison between silver sulfadiazine and centiderm. | burns are common event and associated with a high incidence of death, disability, and high costs. centella asiatica (l.) is a medicinal herb, commonly growing in humid areas in several tropical countries that improve wound healing. on the basis of previous studies, we compared the efficacy of centiderm versus silver sulfadiazine (ssd) in partial thickness burning patients. | 2017 | 28248871 |
| asiaticoside: attenuation of rotenone induced oxidative burden in a rat model of hemiparkinsonism by maintaining the phosphoinositide-mediated synaptic integrity. | asiaticoside (as), a triterpenoid saponin isolated from the indian medicinal herb centella asiatica is known to exert a neuroprotective effect by attenuating the neurobehavioral, neurochemical and pathological changes in animal models. however, its potential neuroprotection in rotenone-induced hemiparkinsonism which implicates phospholipid-mediated neurotransmission remains unclear. therefore, we have investigated the neuroprotective effects of as in rat model of rot-infused hemiparkinsonism wit ... | 2017 | 28238857 |
| neurotrophic effect of asiatic acid, a triterpene of centella asiatica against chronic 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine hydrochloride/probenecid mouse model of parkinson's disease: the role of mapk, pi3k-akt-gsk3β and mtor signalling pathways. | regulation of various signalling (ras-mapk, pi3k and akt) pathways by augmented activity of neurotrophic factors (ntfs) could prevent or halt the progress of dopaminergic loss in parkinson's disease (pd). various in vitro and in vivo experimental studies indicated anti-parkinsonic potential of asiatic acid (aa), a pentacyclic triterpene obtained from centella asiatica. so the present study is designed to determine the neurotrophic effect of aa against 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyrid ... | 2017 | 28181071 |
| asiatic acid inhibits lung cancer cell growth in vitro and in vivo by destroying mitochondria. | asiatic acid (aa), a pentacyclic triterpene found in centella asiatica, displays significant anti-proliferative effects on cancer cells in vitro although the underlying mechanism of this effect remains unknown. this study investigated the efficacy and mechanism of action of aa against lung cancer both in vivo and in vitro. using the mtt assay, aa was found to induce apoptosis in a dose- and time-dependent manner, an effect enhanced by pretreatment with an autophagy inhibitor. it also elevated ex ... | 2017 | 28119810 |
| asiatic acid enhances nrf2 signaling to protect hepg2 cells from oxidative damage through akt and erk activation. | asiatic acid (aa), a natural triterpene isolated from the plant centella asiatica, have antioxidative potential, but the molecular mechanism of aa against oxidative stress remains unclear. our study was performed to investigate the antioxidative effect of aa against oxidative stress and the antioxidative mechanism in tert-butyl hydroperoxide (t-bhp) -stimulated the hepg2 cells. the results showed that aa suppressed t-bhp-induced cytotoxicity, apoptosis, and reactive oxygen species (ros) generati ... | 2017 | 28110191 |
| asiatic acid attenuates pre-neoplastic lesions, oxidative stress, biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis. | asiatic acid (aa), a pentacyclic triterpenoid, derived from the tropical medicinal plant centella asiatica is known to exhibit numerous pharmacological properties. we hypothesized that aa will have chemopreventive potential against 1,2-dimethylhydrazine (dmh)-induced experimental colon carcinogenesis in male wistar rats. rats were arbitrarily divided into six groups. group i rats were processed as control. group ii rats received aa (8 mg/kg b.w., p.o.) and groups iii-vi rats received subcutaneou ... | 2017 | 28004603 |
| comparative pharmacokinetics between madecassoside and asiaticoside presented in a standardised extract of centella asiatica, eca 233 and their respective pure compound given separately in rats. | 1. eca 233, the standardised extract of centella asiatica, contains not less than 80% triterpenoid glycosides, in a madecassoside:asiaticoside ratio of 1.5 (±0.5):1. 2. the pharmacokinetic comparison of madecassoside and asiaticoside was performed in rats following intravenous and oral administration of eca 233, or an equivalent dose of the individual compounds. blood, tissues, urine and faeces were collected after dosing to determine drug and metabolite levels using liquid chromatography-tandem ... | 2017 | 28001462 |
| pva-peg physically cross-linked hydrogel film as a wound dressing: experimental design and optimization. | the development of hydrogel films as wound healing dressings is of a great interest owing to their biological tissue-like nature. polyvinyl alcohol/polyethylene glycol (pva/peg) hydrogels loaded with asiaticoside, a standardized rich fraction of centella asiatica, were successfully developed using the freeze-thaw method. response surface methodology with box-behnken experimental design was employed to optimize the hydrogels. the hydrogels were characterized and optimized by gel fraction, swellin ... | 2017 | 28378604 |
| preclinical safety assessment of standardized extract of centella asiatica (l.) urban leaves. | centella asiatica (ca) leaves extract has been shown therapeutic potential. however, safety information is lacking. | 2017 | 26862255 |
| pycnogenol® and centella asiatica to prevent asymptomatic atherosclerosis progression in clinical events. | the aim of this study was to evaluate the effect of the nutritional supplements pycnogenol® and centella asiatica (ca) on atherosclerosis progression in low-risk, asymptomatic subjects with carotid or femoral stenosing plaques. | 2017 | 26505327 |
| artificial neural network-based model for the prediction of optimal growth and culture conditions for maximum biomass accumulation in multiple shoot cultures of centella asiatica. | an artificial neural network (ann)-based modelling approach is used to determine the synergistic effect of five major components of growth medium (mg, cu, zn, nitrate and sucrose) on improved in vitro biomass yield in multiple shoot cultures of centella asiatica. the back propagation neural network (bpnn) was employed to predict optimal biomass accumulation in terms of growth index over a defined culture duration of 35 days. the four variable concentrations of five media components, i.e. mgso4 ( ... | 2017 | 27068291 |
| wound-healing effect of electrospun gelatin nanofibres containing centella asiatica extract in a rat model. | centella asiatica (ca) is a traditional herbal medicine that has been shown to exert pharmacological effects on wound healing. this study demonstrated that ca extract facilitates the wound-repair process by promoting fibroblast proliferation and collagen synthesis and exhibits antibacterial activity. gelatin nanofibres containing c. asiatica extract were fabricated via electrospinning and were shown to exhibit dermal wound-healing activity in a rat model. the wound areas of rat skin treated with ... | 2017 | 25711743 |