Publications
Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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ethnoveterinary medicinal plants used by the maale and ari ethnic communities in southern ethiopia. | livestock production is an integral part of the agricultural system in ethiopia. medicinal plants are used and are important for rural communities for the treatment of livestock diseases. we studied and analysed the traditional medicinal plants used for the treatment of livestock diseases by the maale and ari ethnic communities in southern ethiopia. | 2014 | 24576407 |
determination of trace and heavy metals in some commonly used medicinal herbs in ayurveda. | traditionally, the herbal drugs are well established for their therapeutic benefits. depending upon their geographical sources sometimes the trace and heavy metals' content may differ, which may lead to severe toxicity. so, the toxicological and safety assessment of these herbal drugs are one of the major issues in recent days. eight different plant species including aloe vera, centella asiatica, calendula officinalis, cucumis sativus, camellia sinensis, clitoria ternatea, piper betel and tagete ... | 2014 | 23222691 |
medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review. | burn wound healing is a complicated process including inflammation, re-epithelialization, granulation, neovascularization and wound contraction. several biochemicals are involved in burn healing process including antioxidants, cytokines and liver and kidney damage biomarkers. although several preparations are available for the management of burn wound, there is still a necessity of researching for efficacious medicine. the aim of the present study was to evaluate herbal preparations and their ph ... | 2014 | 24895176 |
useful ethnophytomedicinal recipes of angiosperms used against diabetes in south east asian countries (india, pakistan & sri lanka). | this paper is based on data recorded from various literatures pertaining to ethnophytomedicinal recipes used against diabetes in south east asia (india, pakistan and srilanka). traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. in total 419 useful phytorecipes of 270 plant species belonging to 74 angiospermic families were collected. from the review it was revealed that plants showing hypoglycemic potential mainly belong to the families, cucurb ... | 2014 | 25176368 |
effects of dietary centella asiatica (l.) urban on growth performance, nutrient digestibility, blood composition in piglets vaccinated with mycoplasma hyopneumoniae. | to investigate the effects of centella asiatica (l.) on growth performance, nutrient digestibility and blood composition in piglets, 32 nursery pigs were fed 0.0, 0.5, 1.0 and 2.0% dietary c. asiatica (l.) from 15 to 90 kg bw. at 30 kg bw, nutrient digestibility was measured and at 35 kg bw piglets were vaccinated with mycoplasma hyopneumoniae. hematological parameters were checked at 40 and 80 kg bw. compared with the control, growth performance was not affected. the ether extract, ash and calc ... | 2014 | 24612418 |
effectiveness of traditional malaysian vegetables (ulam) in modulating blood glucose levels. | ulam refers to a group of traditional malaysian plants commonly consumed as a part of a meal, either in the raw form or after a short blanching process. many types of ulam are thought to possess blood glucose-lowering properties, but relatively little is known on the effectiveness of ulam in modulating blood glucose levels in humans. this review aims to systematically evaluate the effectiveness of ulam in modulating blood glucose levels in humans. a literature review was conducted using multiple ... | 2014 | 25164446 |
ethnopharmacological survey of medicinal plants used by traditional health practitioners in thanchi, bandarban hill tracts, bangladesh. | there is very limited information regarding plants used by traditional healers in bandarban hill tracts (bht), bangladesh for treating general as well as complex ailments. current study provides significant ethnopharmacological information, both qualitative and quantitative on medical plants in bht. aim of the study this study aimed to collect, analyze and evaluate the rich ethnopharmacologic knowledge on medicinal plants in thanchi, bht and attempted to identify the important species used in tr ... | 2014 | 24892834 |
a review of commercially important african medicinal plants. | data on the relative importance and research status of commercially relevant african medicinal plants are needed for developing new research strategies in order to stimulate much-needed ethnopharmacological research and to promote the commercialization of african plants. | 2015 | 26498493 |
bioavailability of calcium and its absorption inhibitors in raw and cooked green leafy vegetables commonly consumed in india--an in vitro study. | the objectives of this research were to assess the bioavailability of calcium using equilibrium dialysis after simulated gastric digestion method in 20 commonly consumed green leafy vegetables (glvs) from the typical indian diet, provide data on the content of calcium absorption inhibitors, like oxalate, phytate, tannin and dietary fibres, and evaluate the inhibitory effect of these compounds on calcium bioavailability in raw and cooked glvs. cooking did not affect significantly calcium bioavail ... | 2015 | 25306367 |
gotu kola (centella asiatica): nutritional properties and plausible health benefits. | centella asiatica l. (gotu kola) is a nutritionally important plant and a valued traditional medicine in south east asia. in this review, the chemical composition, nutritional values, and health benefits of c. asiatica have been discussed in detail to emphasize its usage as traditional food and medicine. c. asiatica is one of the most commonly used green leafy vegetables (glvs) in some countries including sri lanka due to its high amounts of medicinally important triterpenoids and beneficial car ... | 2015 | 26602573 |
unusual microbial lactonization and hydroxylation of asiatic acid by umbelopsis isabellina. | asiatic acid (1) is a natural triterpenoid isolated from centella asiatica. this paper reports the microbial transformation of asiatic acid by an endophytic fungus umbelopsis isabellina to obtain derivatives potentially useful for further studies. incubation of asiatic acid with u. isabellina afforded two derivatives 2α,3β,7β, 23-tetrahydroxyurs-12-ene-28-oic acid (2) and 2α,3β,7β,23-tetrahydroxyurs-11-ene-28,13-lactone (3). the structures of these compounds were elucidated by spectral data. com ... | 2015 | 26194478 |
synthesis and evaluation of asiatic acid derivatives as anti-fibrotic agents: structure/activity studies. | fibrotic diseases are characterized by the over-accumulation of fibrous components in the extracellular matrix and the liver, which can lead to liver cirrhosis. current treatment options cannot reverse or halt liver fibrosis, motivating a search for newer treatment options. previously, we showed that asiaticoside, a bioactive triterpene glycoside from centella asiatica, has anti-fibrotic properties. here, the aglycone asiatic acid was chemically modified, and these derivatives were evaluated for ... | 2015 | 25461275 |
structural analysis of metabolites of asiatic acid and its analogue madecassic acid in zebrafish using lc/it-msn. | although zebrafish has become a significant animal model for drug discovery and screening, drug metabolism in zebrafish remains largely unknown. asiatic acid (aa) and madecassic acid (ma), two natural pentacyclic triterpenoids mainly obtained from centella asiatica (l.) urban, have been found to possess many pharmacological effects. this study is to probe the metabolic capability of zebrafish via investigation of the drug metabolism of aa and ma in zebrafish, using a sensitive lc/it-msn method. ... | 2015 | 25685908 |
investigation of cyp3a4 and cyp2d6 interactions of withania somnifera and centella asiatica in human liver microsomes. | withania somnifera is commonly used as a rejuvenator, whereas centella asiatica is well known for its anxiolytic and nootropic effects. the present study aims at investigating the effect of crude extracts and principal phytoconstituents of both the medicinal plants with cyp3a4 and cyp2d6 enzyme activity in human liver microsomes (hlm). phytoconstituents were quantified in the crude extracts of both the medicinal plants using reverse phase hplc. crude extracts and phytoconstituents of w. somnifer ... | 2015 | 25684704 |
review on ethnomedicinal, phytochemical and pharmacological evidence of himalayan anticancer plants. | himalayan plants have 6500 years old history of being using as traditional medicines. inhabitants of the region use indigenous knowledge for the preparation of various herbal recipes in order to treat different kinds of cancer. the aim of this review is to provide ethnopharmacological, phytochemical and toxicological overview of himalayan medicinal plants having anticancer potential. this will provide a baseline for the discovery of new anticancer drugs. | 2015 | 25680842 |
centella asiatica attenuates amyloid-β-induced oxidative stress and mitochondrial dysfunction. | we previously showed that a water extract of the medicinal plant centella asiatica (caw) attenuates amyloid-β (aβ)-induced cognitive deficits in vivo, and prevents aβ-induced cytotoxicity in vitro. yet the neuroprotective mechanism of caw is unknown. | 2015 | 25633675 |
simultaneous interstitial pneumonitis and cardiomyopathy induced by venlafaxine. | venlafaxine is a serotonin-norepinephrine reuptake inhibitor used as an antidepressant. interindividual variability and herb-drug interactions can lead to drug-induced toxicity. we report the case of a 35-year-old female patient diagnosed with synchronous pneumonitis and acute cardiomyopathy attributed to venlafaxine. the patient sought medical attention due to dyspnea and dry cough that started three months after initiating treatment with venlafaxine for depression. the patient was concomitantl ... | 2015 | 25029655 |
dynamics of flavonol accumulation in leaf tissues under different uv-b regimes in centella asiatica (apiaceae). | a cumulative effect of uv-b doses on epidermal flavonol accumulation was observed during the first week of a time course study in centella asiatica (apiaceae). however, once flavonol levels had peaked, additional accumulation was possible only if higher daily uv-b irradiances were applied. we aimed to understand the dynamics of flavonol accumulation in leaf tissues using non-destructive spectroscopy and hplc-mass spectrometry. when leaves that had grown without uv-b were given brief daily exposu ... | 2015 | 25896373 |
synthetic and natural inhibitors of phospholipases a2: their importance for understanding and treatment of neurological disorders. | phospholipases a2 (pla2) are a diverse group of enzymes that hydrolyze membrane phospholipids into arachidonic acid and lysophospholipids. arachidonic acid is metabolized to eicosanoids (prostaglandins, leukotrienes, thromboxanes), and lysophospholipids are converted to platelet-activating factors. these lipid mediators play critical roles in the initiation, maintenance, and modulation of neuroinflammation and oxidative stress. neurological disorders including excitotoxicity; traumatic nerve and ... | 2015 | 25891385 |
a molecular docking study of phytochemical estrogen mimics from dietary herbal supplements. | the purpose of this study is to use a molecular docking approach to identify potential estrogen mimics or anti-estrogens in phytochemicals found in popular dietary herbal supplements. | 2015 | 25878948 |
asiaticoside attenuates lipopolysaccharide-induced acute lung injury via down-regulation of nf-κb signaling pathway. | asiaticoside (as), a triterpene glycoside isolated from centella asiatica, has been shown to possess potent anti-inflammatory activity. however, the detailed molecular mechanisms of as on lipopolysaccharide (lps)-induced acute lung injury (ali) model in mice are scanty. the purpose of this study was to evaluate the effect of as on lps-induced mouse ali via down-regulation of nf-κb signaling pathway. we investigated the efficacy of as on cytokine levels induced by lps in bronchoalveolar lavage fl ... | 2015 | 25835778 |
synergy effects of three plant extracts on protection of gastric mucosa. | the gastric mucosa protection effect of three natural plant extracts, hericium erinaceus (he), centella asiatica (ca) and amomum villosum (av), were evaluated using the indomethacin damage model. compared with a single extract, a combination of he/ca/av, especially with the ratios of 80:10:10, 45:45:10 and 45:10:45, showed significant synergistic effects for protection of the gastric mucosa with gastric ulcer inhibition rates of 97.8 ± 0.7%, 86.5 ± 2.8% and 86.1 ± 3.6%, respectively. microscopic ... | 2015 | 26749844 |
mechanical properties and in vivo healing evaluation of a novel centella asiatica-loaded hydrocolloid wound dressing. | to develop a novel sodium alginate based centella asiatica (ca)-loaded hydrocolloid wound dressing (hcd) providing excellent mechanical properties and improved wound healing, numerous ca-loaded hcds were prepared with various ingredients using the hot melting method. the effect of sodium alginate, styrene-isoprene-styrene copolymer (sis) and petroleum hydrocarbon resin (phr) on the mechanical properties of ca-loaded hcds was investigated. the effect of disintegrants on swelling and drug release ... | 2015 | 26024819 |
evaluation of the anxiolytic and antidepressant effects of asiatic acid, a compound from gotu kola or centella asiatica, in the male sprague dawley rat. | herbal medication use continues to rise and interactions with existing medications propose risks and may have significant effects and consequences on the administration of anesthesia. the purpose of this study was to investigate the anxiolytic and antidepressant effects of asiatic acid and its potential modulation of the γ-aminobutyric acid (gabaa) receptor. fifty-five male sprague dawley rats were divided into 5 groups: vehicle (dmso), asiatic acid (aa), midazolam, or a combination of flumazeni ... | 2015 | 26016167 |
asiatic acid attenuates the progression of left ventricular hypertrophy and heart failure induced by pressure overload by inhibiting myocardial remodeling in mice. | cardiac structural remodeling, including cardiomyocyte apoptosis, interstitial fibrosis, and inflammation, appears to be a key event associated with the progression of left ventricular hypertrophy and heart failure. asiatic acid (aa) is a triterpenoid compound extracted from centella asiatica that exhibits antiapoptotic, antifibrotic, and anti-inflammatory activities. in the present study, a transverse aortic constriction (tac) model was created in mice to mimic the progression of hypertrophy (2 ... | 2015 | 26647013 |
in vitro assessment of cyp1a2 and 2c9 inhibition potential of withania somnifera and centella asiatica in human liver microsomes. | several herbal drugs and allopathic medicines when co-administered can lead to severe herb-drug interactions. hence, this study was undertaken in order to assess the in vitro inhibition potential of withania somnifera and centella asiatica with cytochrome p450 (cyp) 1a2 and 2c9 enzyme using human liver microsomes. | 2015 | 25938222 |
treatment of renal fibrosis by rebalancing tgf-β/smad signaling with the combination of asiatic acid and naringenin. | we recently showed that imbalance of tgf-β/smad signaling with over-activation of smad3 but lower levels of smad7 is a central mechanism of tissue fibrosis. in the present study, we report here that inhibition of smad3 with naringenin (ng) and upregulation of smad7 with asiatic acid (aa) produced an additive effect on inhibition of renal fibrosis in a mouse model of obstructive nephropathy. we found that aa, a triterpene from centella asiatica, functioned as a smad7 agonist and suppressed tgf-β/ ... | 2015 | 26474462 |
nerve protective effect of asiaticoside against ischemia-hypoxia in cultured rat cortex neurons. | asiaticoside is one of the main functional components of the natural plant centella asiatica urban. studies have reported it has several functions such as anti-depression and nerve cell protection. asiaticoside can reduce the cerebral infarct size in acute focal cerebral ischemia in a mouse model and asiatic acid glycosides can significantly improve neurobehavioral scores. currently, there is a lack of understanding of asiaticoside in regard to its neural protective mechanism in cerebral ischemi ... | 2015 | 26447863 |
effects of asiatic acid on spatial working memory and cell proliferation in the adult rat hippocampus. | asiatic acid is a pentacyclic triterpene from centella asiatica. previous studies have reported that asiatic acid exhibits antioxidant and neuroprotective activities in cell culture. it also prevents memory deficits in animal models. the objective of this study was to investigate the relationship between spatial working memory and changes in cell proliferation within the hippocampus after administration of asiatic acid to male spraque-dawley rats. control rats received vehicle (propylene glycol) ... | 2015 | 26445061 |
pycnogenol® and centella asiatica in the management of asymptomatic atherosclerosis progression. | the aim of the study was to evaluate the effect of the nutritional supplements pycnogenol® and total triterpenic fraction of centella asiatica (ttfca) on atherosclerosis progression in low-risk asymptomatic subjects with carotid or femoral stenosing plaques. | 2015 | 25519846 |
e-microsatellite markers for centella asiatica (gotu kola) genome: validation and cross-transferability in apiaceae family for plant omics research and development. | abstract centella asiatica (gotu kola) is a plant that grows in tropical swampy regions of the world and has important medicinal and culinary use. it is often considered as part of ayurvedic medicine, traditional african medicine, and traditional chinese medicine. the unavailability of genomics resources is significantly impeding its genetic improvement. to date, no attempt has been made to develop expressed sequence tags (ests) derived simple sequence repeat (ssr) markers (essrs) from the cente ... | 2015 | 25562200 |
an ethnobotanical study of medicinal plants in palamalai region of eastern ghats, india. | during the last few decades there has been an increasing interest in the study of medicinal plants with their traditional use and related pharmacological research all over the world. this paper enumerated folk medicinal plants used by malayali tribal people in an unexplored and biodiversity rich region of eastern ghats in southern india. | 2015 | 26068426 |
centella asiatica and lipoic acid, or a combination thereof, inhibit monocyte adhesion to endothelial cells from umbilical cords of gestational diabetic women. | diabetes mellitus is associated with inflammatory endothelial activation and increased vascular leukocyte adhesion molecule expression, both playing a prominent role in the development of vascular complications. centella asiatica (ca) and lipoic acid (la) have shown anti-inflammatory and anti-oxidant properties in a variety of experimental models; however, their action on human umbilical vein endothelial cells (huvecs), chronically exposed to hyperglycemia and pro-inflammatory environment during ... | 2015 | 26026207 |
herbal supplements and hepatotoxicity: a short review. | herbal products have gained popularity over the past few decades. the reasons attributed to the rise in popularity are cheaper costs, easy availability, patient compliance and fewer side effects. however, liver toxicity following consumption of herbal remedies is on the increase. thus, there is an urgent need to understand the mechanism of action of the herbal supplements on the liver. occasionally, herbal supplements may also interact with conventional drugs. the present review focusses on a fe ... | 2015 | 26669124 |
molecular cloning, characterization and expression analysis of 3-hydroxy-3-methylglutaryl coenzyme a reductase gene from centella asiatica l. | 3-hydroxy-3-methylglutaryl-coa reductases (hmgr) plays an important role in catalyzing the first committed step of isoprenoid biosynthesis in the mevelonic (mva) pathway (catalyzes the conversion of hmg-coa to mva) in plants. the present manuscript reports the full length cdna cloning of hmgr (cahmgr, genbank accession number: kj939450.2) and its characterization from centella asiatica. sequence analysis indicated that the cdna was of 1965 bp, which had an open reading frame of 1617 bp and encod ... | 2015 | 26311154 |
seasonal variation of triterpenes and phenolic compounds in australian centella asiatica (l.) urb. | specific triterpenes, phenolic acids and flavonoids in centella asiatica have been found to be bioactive. harvesting the plant when these putative bioactive compounds are at their highest concentrations would provide consistency in their chemical profile, thus ensuring the quality and efficacy of derived medicinal products. | 2015 | 26219274 |
the potential of asiaticoside for tgf-β1/smad signaling inhibition in prevention and progression of hypoxia-induced pulmonary hypertension. | asiaticoside (as) is a saponin monomer extracted from the medicinal plant centella asiatica, which has a variety of biological effects. we intended to investigate the effects of asiaticoside on a hypoxia-induced pulmonary hypertension (hph) rat model and examine the possible effects of asiaticoside on tgf-β1/smad signaling in vivo and in vitro. | 2015 | 26209140 |
asiaticoside inhibits tnf-α-induced endothelial hyperpermeability of human aortic endothelial cells. | the increase in endothelial permeability often promotes edema formation in various pathological conditions. tumor necrosis factor-alpha (tnf-α), a pro-atherogenic cytokine, impairs endothelial barrier function and causes endothelial dysfunction in early stage of atherosclerosis. asiaticoside, one of the triterpenoids derived from centella asiatica, is known to possess antiinflammatory activity. in order to examine the role of asiaticoside in preserving the endothelial barrier, we assessed its ef ... | 2015 | 26171791 |
dietary supplements used in the treatment of depression, anxiety, and sleep disorders. | dietary supplement use has increased during the past decade. epidemiologic studies suggest that patients turn to dietary supplements because of a reluctance to take prescription medications or a lack of satisfaction with the results. they often perceive dietary supplements to be a safer or more natural alternative. patients with mental health conditions, including depression, anxiety, and sleep disorders, are among those who use dietary supplements. st. john's wort is used to treat depression. c ... | 2015 | 10711131 |
new innovations in scar management. | as current aesthetic surgical techniques become more standardized and results more predictable, a fine scar may be the demarcating line between acceptable and unacceptable aesthetic results. with this in mind, a scar management program has been adopted based on the modalities of wound support, hydration, and hastened maturity, all factors gleaned from scientific evidence published over the past 25 years. tension on a scar in one axis will result in a stretched scar, probably initiated by neutrop ... | 2015 | 10890953 |
[anthrone determination of the asiaticoside isolated from centella asiatica by quantitative chromatography on thin layers of glass powder]. | 2015 | 14048142 | |
night eating syndrome and gotu kola. | 2015 | 16445150 | |
production of polyclonal antibody against madecassoside and development of immunoassay methods for analysis of triterpene glycosides in centella asiatica. | centella asiatica (l.) urban consists of two major triterpene glycosides, asiaticoside (as) and madecassoside (ma), as active components used for wound healing and enhancing memory. | 2015 | 23081750 |
intestinal interleukin-10 mobilization as a contributor to the anti-arthritis effect of orally administered madecassoside: a unique action mode of saponin compounds with poor bioavailability. | madecassoside, a triterpenoid saponin present in centella asiatica herbs with extremely low bioavailability, possesses excellent anti-rheumatoid arthritis property after oral administration. such a disconnection between poor pharmacokinetic property and undoubted bioactivity also exists in many other herbal medicines. however, there is no reasonable explanation for this phenomenon to date. here we showed that orally administered madecassoside displayed marked therapeutic effect on collagen-induc ... | 2015 | 25600909 |
biopharmaceutical and pharmacokinetic characterization of asiatic acid in centella asiatica as determined by a sensitive and robust hplc-ms method. | asiatic acid is one of the main components in the herb centella asiatica, which is a well-known herbal medicine for its excellent pharmacological effects. to enhance the development potentials of asiatic acid as a chemopreventative agent, there is a great need to further understand its biopharmaceutical and pharmacokinetic properties. the aim of this research is to clarify the mechanisms of absorption and metabolism of asiatic acid, and explore its biopharmaceutical and pharmacokinetic propertie ... | 2015 | 25596352 |
prophylactic effects of asiaticoside-based standardized extract of centella asiatica (l.) urban leaves on experimental migraine: involvement of 5ht1a/1b receptors. | the present study aimed at evaluation of prophylactic efficacy and possible mechanisms of asiaticoside (as) based standardized extract of centella asiatica (l.) urban leaves (indca) in animal models of migraine. the effects of oral and intranasal (i.n.) pretreatment of indca (acute and 7-days subacute) were evaluated against nitroglycerine (ntg, 10 mg·kg(-1), i.p.) and bradykinin (bk, 10 μg, intra-arterial) induced hyperalgesia in rats. tail flick latencies (from 0 to 240 min) post-ntg treatment ... | 2015 | 25908624 |
centella asiatica and its fractions reduces lipid peroxidation induced by quinolinic acid and sodium nitroprusside in rat brain regions. | oxidative stress has been implicated in several pathologies including neurological disorders. centella asiatica is a popular medicinal plant which has long been used to treat neurological disturbances in ayurvedic medicine. in the present study, we quantified of compounds by high performance liquid chromatography (hplc) and examined the phenolic content of infusion, ethyl acetate, n-butanolic and dichloromethane fractions. furthermore, we analyzed the ability of the extracts from c. asiatica to ... | 2015 | 25903808 |
isolation and identification of an antifungal compound from endophytic streptomyces sp. cen26 active against alternaria brassicicola. | 2,5-bis(hydroxymethyl)furan monoacetate (bhmf-oac) compound was isolated from the culture filtrate secreted by streptomyces sp. cen26, an endophytic actinomycete found in the root nodes of centella asiatica (l.) urban. the compound was purified using various chromatographic techniques and bioassay-guided fractionation. the compound was then identified through a structural characterization using (1) h, (13) c-nmr and ms analysis. after the purification and identification process, a series of expe ... | 2016 | 27163966 |
centella asiatica extract protects against amyloid β1-40-induced neurotoxicity in neuronal cells by activating the antioxidative defence system. | centella asiatica ( léi gōng gēn) is a traditional medicinal herb with high antioxidant activity, which decreases amyloid-β (aβ) deposition in the brain. at the same time, aggregated aβ-induced oxidative stress is the trigger in the pathogenesis of alzheimer's disease (ad). here, we investigated the ability of c. asiatica ethanol extract (cae) to protect pc12 and imr32 cells from aβ1-40-induced production of reactive oxygen species (ros) and concomitant neurotoxicity. aggregated aβ1-40 treatment ... | 2016 | 27774420 |
centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice. | this study investigates the cognitive enhancing effects of the plant centella asiatica which is widely used ayurvedic and traditional chinese medicine. | 2016 | 26785167 |
metabolic alteration in obese diabetes rats upon treatment with centella asiatica extract. | 'pegaga' is a traditional malay remedy for a wide range of complaints. among the 'pegaga', centella asiatica has been used as a remedy for diabetes mellitus. thus, we decided to validate this claim by evaluating the in vivo antidiabetic property of c. asiatica (ca) on t2dm rat model using the holistic (1)h nmr-based metabolomics approach. | 2016 | 26775274 |
possible involvement of nitric oxide modulatory mechanisms in the neuroprotective effect of centella asiatica against sleep deprivation induced anxiety like behaviour, oxidative damage and neuroinflammation. | sleep deprivation (sd) is an experience of inadequate or poor quality of sleep that may produce significant alterations in multiple neural systems. centella asiatica (ca) is a psychoactive medicinal herb with immense therapeutic potential. the present study was designed to explore the possible nitric oxide (no) modulatory mechanism in the neuroprotective effect of ca against sd induced anxiety like behaviour, oxidative damage and neuroinflammation. male laca mice were sleep deprived for 72 h, an ... | 2016 | 26848139 |
purification of a recombinant polyhistidine-tagged glucosyltransferase using immobilized metal-affinity chromatography (imac). | short peptide tags genetically fused to recombinant proteins have been widely used to facilitate detection or purification without the need to develop specific procedures. in general, an ideal affinity tag would allow the efficient purification of tagged proteins in high yield, without affecting its function. here, we describe the purification steps to purify a recombinant polyhistidine-tagged glucosyltransferase from centella asiatica using immobilized metal affinity chromatography. | 2016 | 26843168 |
from plant extract to a cdna encoding a glucosyltransferase candidate: proteomics and transcriptomics as tools to help elucidate saponin biosynthesis in centella asiatica. | centella asiatica (l.) urban (apiaceae), a small annual plant that grows in india, sri lanka, malaysia, and other parts of asia, is well-known as a medicinal herb with a long history of therapeutic uses. the bioactive compounds present in c. asiatica leaves include ursane-type triterpene sapogenins and saponins-asiatic acid, madecassic acid, asiaticoside, and madecassoside. various bioactivities have been shown for these compounds, although most of the steps in the biosynthesis of triterpene sap ... | 2016 | 26843164 |
antifibrotic effect of centella asiatica linn and asiatic acid on arecoline-induced fibrosis in human buccal fibroblasts. | the aim of the present study was to investigate the in vitro antifibrogenic effects of centella asiatica linn (ca) and its bioactive triterpene aglycone asiatic acid (aa) on arecoline-induced fibrosis in primary human buccal fibroblasts (hbf). | 2016 | 26840561 |
chlorogenic acids biosynthesis in centella asiatica cells is not stimulated by salicylic acid manipulation. | exogenous application of synthetic and natural elicitors of plant defence has been shown to result in mass production of secondary metabolites with nutraceuticals properties in cultured cells. in particular, salicylic acid (sa) treatment has been reported to induce the production of phenylpropanoids, including cinnamic acid derivatives bound to quinic acid (chlorogenic acids). centella asiatica is an important medicinal plant with several therapeutic properties owing to its wide spectrum of seco ... | 2016 | 26922726 |
madecassic acid protects against hypoxia-induced oxidative stress in retinal microvascular endothelial cells via ros-mediated endoplasmic reticulum stress. | madecassic acid (ma) is an abundant triterpenoid in centella asiatica (l.) urban. (apiaceae) that has been used as a wound-healing, anti-inflammatory and anti-cancer agent. up to now, the effects of ma against oxidative stress remain unclear. in this study, we investigated the effect of ma and its mechanisms on hypoxia-induced human retinal microvascular endothelial cells (hrmecs). hrmecs were pre-treated with different concentrations of ma (0-50μm) for 30min before being incubated under hypoxia ... | 2016 | 27728894 |
neuroprotective properties of madecassoside from centella asiatica after hypoxic-ischemic injury. | madecassoside is one of increasingly used constituent of centella asiatica, a frequently prescribed crude drug in south eastern asia and china for wound healing. in the present experiment, it exposes the neuroprotective nature of madecassoside in gt1-7 cell lines, further, which the antioxidant activities are performed. the cellular toxicity was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay with increased cell viability with ic50 2.5µg/ml. the regulation ... | 2016 | 28375122 |
recent updates in neuroprotective and neuroregenerative potential of centella asiatica. | centella asiatica, locally well known in malaysia as pegaga, is a traditional herb that has been used widely in ayurvedic medicine, traditional chinese medicine, and in the traditional medicine of other southeast asian countries including malaysia. although consumption of the plant is indicated for various illnesses, its potential neuroprotective properties have been well studied and documented. in addition to past studies, recent studies also discovered and/or reconfirmed that c. asiatica acts ... | 2016 | 27540320 |
quantitative determination of catechin as chemical marker in pediatric polyherbal syrup by hplc/dad. | vivabon syrup is a balanced composition of dietary ingredients of phytopharmaceutical nature for maintaining the physique, vigor, vitality and balanced growth of children. the herbal ingredients of pediatric syrup are rich in bioflavonoid, proteins, vitamins, glycosides and trace elements. vivabon is formulated with herbal drugs such as phoenix sylvestris, emblica officinalis, withania somnifera, centella asiatica, amomum subulatum, zingiber officinalis, trigonella foenum-graecum, centaurea behe ... | 2016 | 27165575 |
neuroprotective effect of asiatic acid on rotenone-induced mitochondrial dysfunction and oxidative stress-mediated apoptosis in differentiated sh-sys5y cells. | parkinson's disease (pd) is a chronic neurodegenerative disease, manifested due to the loss of dopaminergic neurons, which ultimately leads to impaired movement in elderly populations. the pathogenesis of pd is associated with numerous factors including oxidative stress, mitochondrial dysfunction and apoptosis. there is no effective therapy available to cure or halt the progression of this disease still now. asiatic acid (aa) is a triterpene extracted from centella asiatica has been reported as ... | 2016 | 26856988 |
asiatic acid exerts anticancer potential in human ovarian cancer cells via suppression of pi3k/akt/mtor signalling. | context asiatic acid, a triterpenoid compound extracted from the tropical medicinal plant centella asiatica (family: apiaceae), has exhibited various biological activities. objective this study was performed to investigate the cytotoxic effects of asiatic acid on human ovarian cancer cells. materials and methods skov3 and ovcar-3 ovarian cancer cells were exposed to different concentrations of asiatic acid (10-100 μg/ml) for 72 or 48 h. cell viability, colony formation, cell cycle distribution, ... | 2016 | 26984021 |
identification of centella asiatica's effective ingredients for inducing the neuronal differentiation. | centella asiatica, commonly known as gotu kola, has been widely used as a traditional herb for decades. yet, the study on which compounds or compound combinations actually lead to its brain benefits remains scarce. to study the neuroprotection effects of centella asiatica, neuronal differentiation of pc12 cells was applied. in our pilot study, we isolated 45 centella asiatica fractions and tested their abilities for inducing neuronal differentiation on pc12 cells. the most effective fraction sho ... | 2016 | 27446228 |
asiatic acid inhibits lipopolysaccharide-induced acute lung injury in mice. | asiatic acid (aa), a major triterpene isolated from centella asiatica (l.) urban, is known to exert various pharmacological activities, including anti-inflammatory and antioxidant effects. the aim of this study was to evaluate the anti-inflammatory effects of aa on lipopolysaccharide (lps)-induced acute lung injury (ali) and clarify the underlying mechanisms. lung pathological changes were assessed by h&e staining. the myeloperoxidase (mpo) activity was detected by mpo assay. the levels of infla ... | 2016 | 27395046 |
effectiveness of gotu kola extract 750 mg and 1000 mg compared with folic acid 3 mg in improving vascular cognitive impairment after stroke. | this study aimed to determine the effectiveness of gotu kola (centella asiatica) in improving cognitive function in patients with vascular cognitive impairment (vci). this study uses a quasi-experimental design. subjects in this study were patients with poststroke cognitive impairment who were treated at two hospitals in yogyakarta, indonesia. the number of subjects was 48: 17 subjects were treated with 1000 mg/day of gotu kola extract, 17 subjects treated with 750 mg/day of gotu kola extract, a ... | 2016 | 27340413 |
ctg-loaded liposomes as an approach for improving the intestinal absorption of asiaticoside in centella total glucosides. | centella total glucosides (ctg),obtained from centella asiatica (l.), have been shown to possess a multitude of pharmacological activities, however, oral administeration of ctg failed to fulfill their therapeutic potentials due to the low bioavailability. in this study, the author prepared the liposomes encapsulated ctg using the ethanol injection method in order to enhance their intestinal absorption. the average particle size and the polydispersityindex(pdi) of ctg-loaded liposome in a batch a ... | 2016 | 27251012 |
asiatic acid prevents the deleterious effects of valproic acid on cognition and hippocampal cell proliferation and survival. | valproic acid (vpa) is commonly prescribed as an anticonvulsant and mood stabilizer used in the treatment of epilepsy and bipolar disorder. a recent study has demonstrated that vpa reduces histone deacetylase (hdac) activity, an action which is believed to contribute to the effects of vpa on neural stem cell proliferation and differentiation which may explain the cognitive impairments produced in rodents and patients. asiatic acid is a triterpenoid derived from the medicinal plant centella asiat ... | 2016 | 27213437 |
bioassay-guided isolation of wound healing active compounds from echium species growing in turkey. | the roots and root barks of echium sp. have been used to treat ulcers, burns and wounds in traditional turkish medicine. | 2016 | 26947902 |
phytoremediation of iron from red soil of tropical region by using centella asiatica. | the accumulation and removal efficiency of fe by centella asiatica was carried out at various fe concentrations in soil treatments (0, 50, 100, 150 and 200 mg fe/kg soil). iron accumulation in different parts of c. asiatica (leaf, stem and root) was analyzed by atomic absorption spectrophotometer (aas). factorial experiment with a completely randomized design and duncan's test were used for data analyses. the results revealed that c. asiatica have the ability to uptake and accumulate fe signific ... | 2016 | 26940261 |
barrier protective effect of asiatic acid in tnf-α-induced activation of human aortic endothelial cells. | endothelial cell activation is characterized by increased endothelial permeability and increased expression of cell adhesion molecules (cams). this allows monocyte adherence and migration across the endothelium to occur and thereby initiates atherogenesis process. asiatic acid is a major triterpene isolated from centella asiatica (l.) urban and has been shown to possess anti-oxidant, anti-hyperlipidemia and anti-inflammatory activities. | 2016 | 26926181 |
effects of metal-contaminated soils on the accumulation of heavy metals in gotu kola (centella asiatica) and the potential health risks: a study in peninsular malaysia. | centella asiatica is a commonly used medicinal plant in malaysia. as heavy metal accumulation in medicinal plants which are highly consumed by human is a serious issue, thus the assessment of heavy metals in c. asiatica is important for the safety of consumers. in this study, the heavy metal accumulation in c. asiatica and the potential health risks were investigated. samples of c. asiatica and surface soils were collected from nine different sites around peninsular malaysia. the concentration o ... | 2016 | 26687083 |
centella asiatica leaf extract protects against indomethacin-induced gastric mucosal injury in rats. | the present study evaluated the protective effect of centella asiatica (gotu kola) leaf extract (cae) against indomethacin (ind)-induced gastric mucosal injury in rats. gastric mucosal injury was induced by the oral administration of ind to the rats after a 24 h fast. cae (50 or 250 mg/kg) or lansoprazole (a reference drug) was orally administrated 30 min before the ind administration, and 5 h later, the stomachs were removed to quantify the lesions. orally administered cae significantly reduced ... | 2016 | 26469560 |
anti-glioma activity and the mechanism of cellular uptake of asiatic acid-loaded solid lipid nanoparticles. | asiatic acid (aa), a pentacyclic triterpene found in centella asiatica, has shown neuroprotective and anti-cancer activity against glioma. however, owing to its poor aqueous solubility, effective delivery and absorption across biological barriers, in particular the blood brain barrier (bbb), are challenging. solid lipid nanoparticles (slns) have shown a promising potential as a drug delivery system to carry lipophilic drugs across the bbb, a major obstacle in brain cancer therapy. nevertheless, ... | 2016 | 26775062 |
carotid plaque stabilization induced by the supplement association pycnogenol® and centella asiatica (centellicum®). | aim of this registry study was the evaluation of the stability of carotid plaques by ultrasound in asymptomatic subjects with high oxidative stress following supplementation with a combination of the extract from bark of pinus pinaster, pycnogenol®, with an extract from centella asiatica leaves, centellicum®. | 2016 | 26496510 |
effect of salicylic acid on expression level of genes related with isoprenoid pathway in centella (centella asiatica (l.) urban) cells. | in this study, we report the expression level of casqs, cabas and cacys, the genes involved in phytosterol and triterpene metabolic pathway of centella (centella asiatica (l.) urban), in cells elicited with salicylic acid (50-200 µm). reverse transcription-polymerase chain reaction (rt-pcr) and northern blot analysis indicated casqs, cabas, and cacys genes expressed in both the wild-type and cultured cells (with and without elicitation). in elicited cells, expressions of casqs, cabas, and cacys ... | 2016 | 28330156 |
in vitro and in vivo antioxidant, anti-hyperlipidemic properties and chemical characterization of centella asiatica (l.) extract. | the study aimed to identify the phenolic compounds present in centella asiatica (l.) (c. asiatica) extract and evaluate the respective antioxidant potential as well as its cholesterol-lowering effects in the experimental animal model. herein, the antioxidant potential of extracts was assessed by its free radical scavenging activity such as 2, 2-diphenyl -1- picrylhydrazyl as well as reducing capability. the anti-hyperlipidemic effects of c. asiatica extract (cae) were evaluated in high cholester ... | 2016 | 27840607 |
stimulatory effects of acibenzolar-s-methyl on chlorogenic acids biosynthesis in centella asiatica cells. | centella asiatica is a perrenial herb that grows in tropical regions with numerous medicinal properties mostly attributed to the presence of pentacyclic triterpenoids. interestingly, this plant also possess a significant amount of phenylpropanoid-derived chlorogenic acids (cgas) that have recently been reported to confer neuroprotective properties. in a biotechnological attempt to increase the biosynthesis of cga-derivatives in cultured centella cells, acibenzolar-s-methyl was applied as a xenob ... | 2016 | 27733862 |
protective effects of centella asiatica leaf extract on dimethylnitrosamine‑induced liver injury in rats. | oxidative stress in liver injury is a major pathogenetic factor in the progression of liver damage. centella asiatica (l.) urban, known in the united states as gotu kola, is widely used as a traditional herbal medicine in chinese or indian pennywort. the efficacy of centella asiatica is comprehensive and is used as an anti‑inflammatory agent, for memory improvement, for its antitumor activity and for treatment of gastric ulcers. the present study investigated the protective effects of centella a ... | 2016 | 27748812 |
mad ointment ameliorates imiquimod-induced psoriasiform dermatitis by inhibiting the il-23/il-17 axis in mice. | psoriasis is a chronic auto-immune inflammation disease with skin lesions and abnormal keratinocyte proliferation. the il-23/il-17 axis plays an important role in the pathogenesis of psoriasis. madecassoside (mad) was the most important constituents isolated from centella asiatica, which has long been used in dermatology, and it is supposed that mad may have effects on psoriasis. in the present study, the balb/c mice ear and back skin received imq for 6 consecutive days to induce psoriasis-like ... | 2016 | 27540765 |
pharmacokinetics of a standardized extract of centella asiatica eca 233 in rats. | eca 233, a standardized extract of centella asiatica, has been found to exhibit various positive neurological effects and to have a good safety profile. the present study aimed to explore the disposition kinetics of eca 233, containing madecassoside (53.1 %) and asiaticoside (32.3 %), in rats. the extract was intravenously or orally administered at doses from 50 to 200 mg/kg. plasma, tissues, urine, and feces were collected at time points from 0 to 48 h after dosing. the levels of madecassoside ... | 2016 | 27992940 |
chemical structures, production and enzymatic transformations of sapogenins and saponins from centella asiatica (l.) urban. | centella asiatica (l.) urban is a medicinal herb traditionally used in asiatic countries for its multiple therapeutic properties, essentially due to its accumulation of specific pentacylic triterpenoid saponins, mainly asiaticoside and madecassoside and the corresponding sapogenins. this review summarizes the updated knowledge about the chemical structures of about forty centelloids, found as minor metabolites in centella, and all derived from ursane and oleane ring patterns. similarly, the most ... | 2016 | 27491750 |
accelerated stability studies on dried extracts of centella asiatica through chemical, hplc, hptlc, and biological activity analyses. | regulatory guidelines recommend systematic stability studies on a herbal product to establish its shelf life. in the present study, commercial extracts (types i and ii) and freshly prepared extract (type iii) of centella asiatica were subjected to accelerated stability testing for 6 months. control and stability samples were evaluated for organoleptics, ph, moisture, total phenolic content (tpc), asiatic acid, kaempherol, and high-performance thin layer chromatography fingerprints, and for antio ... | 2016 | 27486096 |
efficacy of natural compounds in neurodegenerative disorders. | neurodegenerative disorders represent clusters of serious diseases that results in progressive deterioration of normal structure and physiology of central nervous system. pathophysiology of alzheimer's, parkinson's or other neurodegenerative disorders involves multifaceted permutation of genetic and environmental factors. combinations of lifestyle modification linked with environmental factor jointly or alone represent the largest share of cases of these disorders. etiology of such neuronal dege ... | 2016 | 27651251 |
burn wound healing properties of asiaticoside and madecassoside. | the healing of burn wounds has been widely characterized to be highly intricate, involving processes such as neo-vascularization, granulation, re-epithelialization, inflammation and wound contraction. various therapies are available for the management of burn wounds; however, a truly effective therapeutic strategy has yet to be identified due to safety issues. the aim of the present study was to assess and confirm the burn wound healing properties of the compounds asiaticoside (ae) and madecasso ... | 2016 | 27588048 |
asiatic acid inhibits pulmonary inflammation induced by cigarette smoke. | asiatic acid (aa) is one of the major components of titrated extract of centella asiatica (teca), which has been reported to possess antioxidant and anti-inflammatory activities. the purpose of this study was to investigate the protective effect of aa on pulmonary inflammation induced by cigarette smoke (cs). aa significantly attenuated the infiltration of inflammatory cells in bronchoalveolar lavage fluid (balf) of cs exposure mice. aa also decreased ros production and ne activity, and inhibite ... | 2016 | 27494684 |
an investigation of the differential effects of ursane triterpenoids from centella asiatica, and their semisynthetic analogues, on gabaa receptors. | the ursane triterpenoids, asiatic acid 1 and madecassic acid 2, are the major pharmacological constituents of centella asiatica, commonly known as gotu kola, which is used traditionally for the treatment of anxiety and for the improvement of cognition and memory. using the two-electrode voltage-clamp technique, these triterpenes, and some semisynthetic derivatives, were found to exhibit selective negative modulation of different subtypes of the gabaa receptor expressed in xenopus laevis oocytes. ... | 2016 | 27062315 |
phlebotonics for venous insufficiency. | chronic venous insufficiency (cvi) is a common condition caused by valvular dysfunction with or without associated obstruction, usually in the lower limbs. it might result in considerable discomfort with symptoms such as pain, itchiness and tiredness in the legs. patients with cvi may also experience swelling and ulcers. phlebotonics are a class of drugs often used to treat cvi. this is an update of a review first published in 2005. | 2016 | 27048768 |
asiatic acid attenuates myocardial ischemia/reperfusion injury via akt/gsk-3β/hif-1α signaling in rat h9c2 cardiomyocytes. | myocardial ischemic/reperfusion injury results from severe impairment of coronary blood supply and leads to irreversible cell death, with limited therapeutic possibilities. asiatic acid is a pentacyclic triterpenoid derived from the tropical medicinal plant centella asiatica and serves a variety of bioactivities. in this study, we determined the effect of asiatic acid on myocardial ischemia/reperfusion injury and investigated the underlying mechanisms, using an in vitro rat h9c2 cardiomyocytes m ... | 2016 | 27657024 |
indian herbs for the treatment of neurodegenerative disease. | ayurveda, an ancient system of medicine that is indigenous to india, is believed to be the world's oldest comprehensive health-care system and is now one of the most recognized and widely practiced disciplines of alternative medicine in the world. medicinal herbs have been in use for treating diseases since ancient times in india. ayurvedic therapies with medicinal herbs and herbomineral products generally provide relief without much adverse effects even after prolonged administration. neurodege ... | 2016 | 27651261 |
safety assessment of selected medicinal food plants used in ayurveda through cyp450 enzyme inhibition study. | andrographis paniculata, bacopa monnieri, centella asiatica are mentioned in ayurveda for the management of neurodegenerative disorders. these plants and their phytomolecules like andrographolide, bacoside a and asiaticoside were studied for their inhibition potential on pooled cyp450 as well as human cyp3a4, cyp2d6, cyp2c9 and cyp1a2 by cyp-co complex assay and fluorogenic assay respectively followed by ic50 determination. quantification of bioactive compounds present in the extracts was done b ... | 2016 | 27030208 |
asiatic acid uncouples respiration in isolated mouse liver mitochondria and induces hepg2 cells death. | asiatic acid, one of the triterpenoid components isolated from centella asiatica, has received increasing attention due to a wide variety of biological activities. to date, little is known about its mechanisms of action. here we examined the cytotoxic effect of asiatic acid on hepg2 cells and elucidated some of the underlying mechanisms. asiatic acid induced rapid cell death, as well as mitochondrial membrane potential (mmp) dissipation, atp depletion and cytochrome c release from mitochondria t ... | 2016 | 27288117 |
evaluation of the topical spray containing centella asiatica extract and its efficacy on excision wounds in rats. | centella asiatica was extracted by methanol. the assay content of triterpenes in the extract was 0.12 % asiatic acid, 0.54 % madecassic acid, 0.25 % asiaticoside and 1.02 % madecassoside. the extract was complexed with hydroxypropyl-β-cyclodextrin (hp-β-cd) and formulated with eudragit e100, glycerol, peg 400, copovidone, ethanol and purified water. a clear yellowish solution (f1-f8) was obtained. the formulations had a ph of 5.5-6.0 with viscosity in the range of 20-60 mpa s, surface tension 20 ... | 2016 | 27279066 |
anti-quorum sensing activity of flavonoid-rich fraction from centella asiatica l. against pseudomonas aeruginosa pao1. | inhibition of quorum sensing (qs), a cell-density dependent regulation of gene expression in bacteria by autoinducers is an attractive strategy for the development of antipathogenic agents. | 2016 | 24856426 |
endophytic fungal isolate mediated biosynthesis of silver nanoparticles and their free radical scavenging activity and anti microbial studies. | the present study reports that the biosynthesis of agnps using an endophytic fungus isolated from the ethnomedicinal plant centella asiatica. the endophytic fungus was identified as aspergillus versicolor ent7 based on 18s rrna gene sequencing (ncbi accession number kf493864). the agnps synthesized were characterized by uv-visible spectroscopy, fourier transform infra-red spectroscopy (ftir), transmission electron microscopy (tem), x-ray diffraction (xrd), particle size analyzer, and zeta potent ... | 2016 | 28330204 |
in vitro antimicrobial activity of spices and medicinal herbs against selected microbes associated with juices. | in the present investigation, comparison of antimicrobial activities of different spices, curcuma longa, zingiber officinale, and mentha arvensis, and medicinal herbs, such as withania somnifera, rauvolfia serpentina, emblica officinalis, terminalia arjuna, and centella asiatica, was evaluated. different extraction solvents (acetone, methanol, ethanol, and water) were used and extracts were examined against bacillus cereus, serratia sp., rhodotorula mucilaginosa, aspergillus flavus, and penicill ... | 2016 | 26880927 |
rapid screening and identification of phenolic antioxidants in hydrocotyle sibthorpioides lam. by uplc-esi-ms/ms. | the aim of the study was to identify the phenolic compounds present in hydrocotyle sibthorpioides (hs), centella asiatica (ca) and amaranthus viridis (av) extracts and investigate their respective antioxidant activities. herein, an ultra-high pressure liquid chromatography-mass spectrometer (uplc-ms/ms) analytical method has been developed for the separation, and systematic characterization of the phenolic compounds in hs, ca and av extracts and was compared along with ten standard phenolic comp ... | 2016 | 26948646 |
clinical efficacy test of polyester containing herbal extract dressings in burn wound healing. | technological advancement has assisted in developing various availabilities of wound products that help in not only in healing and preventing infection but also in providing patients' comfort and pain reduction during application. however, most of advanced wound healing products in thailand were imported at high costs to patients. nowadays, there are increased numbers of local researches of herbs that could provide healing environment for successful wound care. herbal wound products are currentl ... | 2016 | 27440796 |
effects of plants on osteogenic differentiation and mineralization of periodontal ligament cells: a systematic review. | this systematic review aimed to evaluate the effects of plants on osteogenic differentiation and mineralization of human periodontal ligament cells. the included studies were selected using five different electronic databases. the reference list of the included studies was crosschecked, and a partial gray literature search was undertaken using google scholar and proquest. the methodology of the selected studies was evaluated using grade. after a two-step selection process, eight studies were ide ... | 2016 | 26822584 |
in vitro and in vivo anti-helicobacter pylori activities of centella asiatica leaf extract. | helicobacter pylori infection is associated with an increased risk of developing upper gastrointestinal tract diseases. however, treatment failure is a major cause of concern mainly due to possible recurrence of infection, the side effects, and resistance to antibiotics. the aim of this study was to investigate the activities of centella asiatica leaf extract (cae) against h. pylori both in vitro and in vivo. the minimum inhibitory concentrations (mics) against 55 clinically isolated strains of ... | 2016 | 27752495 |
large scale screening of ethnomedicinal plants for identification of potential antibacterial compounds. | the global burden of bacterial infections is very high and has been exacerbated by increasing resistance to multiple antibiotics. antibiotic resistance leads to failed treatment of infections, which can ultimately lead to death. to overcome antibiotic resistance, it is necessary to identify new antibacterial agents. in this study, a total of 662 plant extracts (diverse parts) from 222 plant species (82 families, 177 genera) were screened for antibacterial activity using the agar cup plate method ... | 2016 | 26985889 |