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effect of lipoarabinomannan from mycobacterium avium subsp avium in freund's incomplete adjuvant on the immune response of cattle.the aim of the present study was to determine whether lipoarabinomannan (lam), in combination with freund's incomplete adjuvant (fia), was able to improve cell-mediated and antibody-mediated immune responses against ovalbumin (ova) in cattle. twenty-three calves were assigned to four treatment groups, which were subcutaneously immunized with either ova plus fia, ova plus fia and lam from mycobacterium avium subsp avium, fia plus lam, or fia alone. lymphoproliferation, ifn-γ production and cell s ...201222286534
presence of mycobacterium avium subsp. paratuberculosis in alpacas (lama pacos) inhabiting the chilean altiplano.mycobacterium avium subsp. paratuberculosis (map) is the etiologic agent of paratuberculosis. the organism causes disease in both domestically managed and wild ruminant species. south american camelids have a long, shared history with indigenous people in the andes. over the last few decades, increasing numbers of alpacas were exported to numerous countries outside south america. no paratuberculosis surveillance has been reported for these source herds. in this study, individual fecal samples fr ...201627010259
mycobacterial infections in rabbits: from the wild to the laboratory.tuberculous mycobacterial diseases such as leprosy and tuberculosis are ancient diseases that currently continue threatening human health in some countries. non-tuberculous mycobacterial (ntm) infections cause a series of well-defined pathological entities, as well as some opportunistic diseases that have also increased worldwide, being more common among immunocompromised patients but rising also in immunocompetent individuals. reports on natural infections by mycobacteria in rabbits are scarce ...201626799551
detection of mycobacterium avium subspecies in the gut associated lymphoid tissue of slaughtered rabbits.rabbits are susceptible to infection by different species of the genus mycobacterium. particularly, development of specific lesions and isolation of mycobacterium avium subsp. avium and mycobacterium avium subsp. paratuberculosis, both subspecies of the m. avium complex, has been reported in wildlife conditions. although, rabbit meat production worldwide is 200 million tons per year, microbiological data on this source of meat is lacking and more specifically reports of mycobacterial presence in ...201526063469
mycobacterium avium subsp. avium infection in four veal calves: differentiation from intestinal tuberculosis.mycobacterium avium subsp. avium (maa) is an intracellular pathogen belonging to the mycobacterium avium-intracellulare complex (mac). reservoirs of mac are the natural environment, wildlife and domestic animals. in adult bovine, mac infections are typically caused by mycobacterium avium subsp. paratuberculosis (map). maa infections in bovine are rarely reported but may cause clinical disease and pathological lesions similar to those observed in paratuberculosis or those induced by members of th ...201424689051
novel feature of mycobacterium avium subsp. paratuberculosis, highlighted by characterization of the heparin-binding hemagglutinin adhesin.mycobacterium avium subsp. paratuberculosis comprises two genotypically defined groups, known as the cattle (c) and sheep (s) groups. recent studies have reported phenotypic differences between m. avium subsp. paratuberculosis groups c and s, including growth rates, infectivity for macrophages, and iron metabolism. in this study, we investigated the genotypes and biological properties of the virulence factor heparin-binding hemagglutinin adhesin (hbha) for both groups. in mycobacterium tuberculo ...201323974028
pathology of mycobacteriosis in birds. 201222244112
characterization of a mycobacterium avium subsp. avium operon associated with virulence and drug detoxification.the lprg-p55 operon of mycobacterium tuberculosis and mycobacterium bovis is involved in the transport of toxic compounds. p55 is an efflux pump that provides resistance to several drugs, while lprg is a lipoprotein that modulates the host's immune response against mycobacteria. the knockout mutation of this operon severely reduces the replication of both mycobacterial species during infection in mice and increases susceptibility to toxic compounds. in order to gain insight into the function of ...201424967408
real-time quantitative pcr detection of mycobacterium avium subspecies in meat products.the aim of this work was to examine various purchased meat products and to find out if any traces of mycobacterium avium subsp. avium, m. avium subsp. hominissuis, and m. avium subsp. paratuberculosis could be detected in these samples. analysis of the meat products (raw, cooked, and fermented) was performed using a real-time quantitative pcr (qpcr) method for the detection of specific insertion sequences: duplex qpcr for the detection of is900 specific for m. avium subsp. paratuberculosis, and ...201121477480
[production and evaluation of a purified protein derivative from an argentine strain of mycobacterium avium subsp. paratuberculosis].purified protein derivatives (ppds) are non-defined antigens prepared from mycobacteria cultures. they are usually employed to evaluate the specific cellular immune response both in animals and humans. bovine and avian ppds are usually employed as antigens in mycobacterial infections such as tuberculosis and paratuberculosis. nevertheless, ppd from mycobacterium avium subsp. paratuberculosis, (ppdj) is neither commonly used nor frequently available. however, ppd from mycobacterium avium subsp. a ...201523102462
production and proteomic characterisation of purified protein derivative from mycobacterium avium subsp. paratuberculosis.effective diagnosis of johne's disease (jd), particularly at the stage of early subclinical infection, remains one of the greatest challenges for the control of jd worldwide. the ifn-γ test of cell mediated immunity is currently one of the most suitable diagnostics for subclinical infections, however a major limitation of this test is the lack of a standardised purified protein derivative (ppd) antigen (also referred to as johnin ppd or ppdj). while attempting to replace ppdj with more specific ...201222443541
distribution of mycobacterium avium subsp. avium and m. a. hominissuis in artificially infected pigs studied by culture and is901 and is1245 quantitative real time pcr.mycobacterium avium subsp. avium (maa) and m. a. hominissuis (mah) belong to the mycobacterium avium complex (mac) and are frequently associated with diseases in animals and humans. the aim of this study was to develop a system for rapid and accurate real time quantitative pcr (qpcr) identification and quantification of maa and mah. this study included 22 per os infected pigs, of which 10 were infected with maa, 10 with mah and 2 were present as a negative control group. from each animal, 21 dif ...201020227841
mannosylated lipoarabinomannans from mycobacterium avium subsp. paratuberculosis alters the inflammatory response by bovine macrophages and suppresses killing of mycobacterium avium subsp. avium organisms.analysis of the mechanisms through which pathogenic mycobacteria interfere with macrophage activation and phagosome maturation have shown that engagement of specific membrane receptors with bacterial ligands is the initiating event. mannosylated lipoarabinomannan (man-lam) has been identified as one of the ligands that modulates macrophage function. we evaluated the effects of man-lam derived from mycobacterium avium subsp. paratuberculosis (map) on bovine macrophages. man-lam induced a rapid an ...201324098744
[avian mycobacteriosis in humans remains a threat in the czech republic].the members of mycobacterium avium complex belong to the most common agents causing mycobacterioses in humans. they are classified as a potentially patogenic mycobacteria, although mycobacterium avium subsp. avium represent veterinary and economic risks in birds (mainly poultry) as well as mammals (pigs etc.). infected animals and their products (mainly eggs) often come from small household production and pose a risk for human health. the second member of this complex, mycobacterium avium subsp. ...201020401832
molecular detection of mycobacterium avium avium and mycobacterium genavense in feces of free-living scarlet macaw ( ara macao) in costa rica.we conducted a study of the two main populations of free-living scarlet macaws ( ara macao) in costa rica to detect the causal agents of avian tuberculosis using noninvasive techniques. we analyzed 83 fecal samples collected between february and may 2016 from the central and southern pacific areas in the country. using pcr, we first amplified the 16s region of the rrna, common to all mycobacterium species. products from the insertion sequence is901 and from a 155-base pair (bp) dna fragment evid ...201729286261
transcriptional response of respiratory epithelium to nontuberculous mycobacteria.the incidence of pulmonary nontuberculous mycobacterial (pntm) disease is increasing, but host responses in respiratory epithelium infected with ntm are not fully understood.201728915071
characterization and differentiation of mycobacterium avium subsp. paratuberculosis from other mycobacteria using matrix assisted laser desorption/ionization time-of-flight mass spectrometry.mycobacterium avium subsp. paratuberculosis (map), the causative agent of johne's disease in cattle, is responsible for significant economic losses to the us dairy industry. the pathogen has also been associated with chronic human diseases like crohn's disease, type 1 diabetes and multiple sclerosis. determining causation requires rapid characterization and source tracking the pathogen. here, we used matrix-assisted laser desorption/ionization time-of-flight (maldi-tof) mass spectrometry to char ...201728713782
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