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acanthamoeba culbertsoni: electron-dense granules in a highly virulent clinical isolate.the virulence of various amoebic parasites has been correlated with the presence of electron-dense granules (edgs) in the cytoplasm of trophozoites. here, we report the finding by transmission electron microscopy of a large number of edgs in a recent culture of acanthamoeba culbertsoni, isolated from a severe case of human keratitis. when this isolate was maintained in culture for 6 mo, the granules almost disappeared. however, after induction of mice brain lesions with the long-term cultured is ...201627087641
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