Publications

pseudomonas pyocyanea and the arginine dihydrolase system.	non-pigmented strains of pseudomonas pyocyanea occur frequently and this organism has only limited activity in conventional biochemical tests; 50 strains were tested for the presence of arginine dihydrolase and found positive whereas only salmonella sp. and enterobacter sp. among other gram-negative species were positive. the test for arginine dihydrolase is rapid and simple and suitable for routine use.	1964	14149934
enhancing effect on alkalinization of the medium on the activity of erythromycin against gram-negative bacteria.	the antibacterial activity of erythromycin was markedly enhanced by alkalinization of the culture medium or urine within the clinical range (ph 6.0 to 8.2). this effect was demonstrated against recent isolates of escherichia coli, klebsiella pneumoniae, enterobacter sp., and pseudomonas aeruginosa, as well as against staphylococcus aureus and streptococcus faecalis. the urine of normal volunteers was made alkaline by ingestion of sodium bicarbonate or acetazolamide (diamox) during administration ...	1968	4970991
in vitro studies of semisynthetic alpha-(substituted-ureido) penicillins.	the activity of three alpha-(substituted-ureido) penicillins was evaluated in vitro against 599 clinical isolates of gram-negative bacilli, by use of the broth-dilution technique. at a concentration of 12.5 mug or less/ml, bl-p1597 inhibited 90% of isolates of pseudomonas sp., 56% of enterobacter sp., 67% of indole-positive proteus spp., 72% of escherichia coli, and 85% of proteus mirabilis. bl-p1654 had similar activity, whereas bl-p1532 was much less active. at a concentration of 25 mug or les ...	1971	4930281
biological properties of three 3-heterocyclic-thiomethyl cephalosporin antibiotics.	three new cephalosporin antibiotics, prepared by substitution of heterocyclic groups on 7-aminocephalosporanic acid, possess certain desirable chemical or biological properties. all three compounds are active in vitro against a variety of gram-positive and gram-negative bacteria. minimal inhibitory concentrations (mic) of these bactericidal antibiotics were not significantly affected by changes in ph or nacl content of nutrient broth, or by the use of different inoculum sizes. however, agar-dilu ...	1972	5045468
preferred sites of digestion of a ribonuclease from enterobacter sp. in the sequence analysis of bacillus stearothermophilus 5s ribonucleic acid.		1973	4719125
susceptibility of clinical isolates of bacteria to cefoxitin and cephalothin.	the susceptibility of 4,929 unselected clinical isolates of bacteria to cefoxitin and cephalothin was determined by the single-disk method, using a computer-associated electronic zone analyzer to obtain, record, and process measurements of sizes of zones of inhibition. both cefoxitin and cephalothin were effective against most gram-positive strains, including staphylococcus aureus, s. epidermidis, micrococci, and all streptococci except enterococci. the three strains of listeria monocytogenes te ...	1974	15830480
antimicrobial susceptibility of clinical isolates of gram-negative bacilli.	no one can doubt the increased incidence of gram-negative bacillary infections and the importance of an awareness of this increase. today's hospital, where one finds aggressive surgery, patients with multiple indwelling polyethylene lines and foley catheters, and widespread use of prophylactic antibiotics, serves as a haven for resistant gram-negative bacilli. twenty-five strains of escherichia coli, klebsiella sp, enterobacter sp, pseudomonas sp, indole-negative proteus sp, indole-positive prot ...	1975	169593
cinoxacin: in vitro antibacterial studies of a new synthetic organic acid.	cinoxacin (compound 64716) is a synthetic organic acid with antibacterial activity against most aerobic gram-negative bacilli. minimal inhibitory concentrations of cinoxacin (agar-dilution method) were determined for 419 strains. escherichia coli was the most susceptible group of organisms. the majority of klebsiella sp., enterobacter sp., proteus sp., and serratia marcescens were inhibited by 8 mug of cinoxacin per ml. pseudomonas aeruginosa and all gram-positive isolates tested were resistant ...	1975	1094949
[in vitro examination on antibacterial activities of broad-spectrum antibiotics against gram-negative clinical isolates (author's transl)].	in vitro studies were undertaken on clinically isolated strains of various bacteria to examine the antibacterial activity of ampicillin (ab-pc), carbenicillin (cb-pc), sulbenicillin (sb-pc) cephalothin (cet), cefazolin (cez) and gentamicin (gm). fifty three % of escherichia coli strains 53.3% of citrobacter sp., 80% of proteus mirabilis, 42.9% of morganella and 80% of bacteroides sp. were susceptible (mic being not higher than 12.5 mug/ml) to ab-pc. the eight other species were not so susceptibl ...	1975	1104913
effects of mercuric chloride on growth and morphology of selected strains of mercury-resistant bacteria.	a survey of the comparative cytological effects of growth in the presence of mercury by a group of mercury-resistant bacterial cultures and a characterization of the process of bacterial adaptation to hg2+ ion was accomplished. mercury resistance was found to be dependent upon the ability to volatilize mercury from the medium and upon the amount of mercury accumulated by the cells. the results indicate that most cultures which adapt to growth in the presence of hgcl2 exhibit extensive morpholo ...	1975	1115499
in vitro activity and pharmacokinetics in patients of cefamandole, a new cephalsoporin antibiotic.	cefamandole nafate, a new cephalosporin for parenteral use, was evaluated in vitro against 231 recent clinical isolates and in 12 patients. cefamandole had activity equivalent to cefazolin against staphylococcus aureus, escherichia coli, and klebsiella pneumoniae. cefamandole was more active than cephalothin or cefazolin against proteus mirabilis. both cefamandole and cefazolin were as active as cephalothin against s. aureus, were slightly more active against k. pneumoniae, and were considerably ...	1975	1211920
comparison of the antibacterial activities of sisomicin and gentamicin against gram-negative bacteria.	sisomicin was found to be more active on a weight basis than gentamicin against pseudomonas sp., klebsiella sp., and indole-positive proteus. gentamicin was more active than sisomicin against escherichia coli, serratia sp., enterobacter sp., and proteus mirabilis. both antibiotics were very active against methicillin-resistant strains of staphylococcus aureus.	1975	1211927
[a bacteriological study of otitis in dogs (author's transl)].	bacteriological examination of 100 cases of otitis in dogs revealed pure cultures of different microorganisms as follows: staphylococcus aureus from 25 animals; escherichia coli from 10; proteus mirabilis from 20; enterobacter sp. from 18 and klepsiella sp. from 7. mixed cultures of proteus mirabilis, pseudomonas aeruginosa and klepsiella sp. were found in 3 animals; staphylococcus aureus and enterobacter sp. in 5; staphylococcus aureus and proteus mirabilis in 4. enterobacter sp. and klepsiella ...	1975	1236059
epidemiologic aspects of nosocomial infections.	in a currently ongoing surveillance of hospital-associated infections in two metropolitan hospitals in oklahoma, the results over a four-month period suggest at least tentative principles of host-agent relationships in hospital-associated infections. within the urinary tract, the site with the highest number of total isolations, escherichia coli and klebsiella pneumoniae were the most common pathogens. by age, the under 5 and over 60 year age groups had the highest number of isolations. staphylo ...	1976	1257828
comparative activity in vitro of ticarcillin, bl-p1654, and carbenicillin.	the activity of ticarcillin, bl-p1654, and carbenicillin was compared in vitro using a microtiter tube dilution test in mueller-hinton broth against 50 recent clinical isolates each of staphylococcus aureus, staphylococcus epidermidis, escherichia coli, klebsiella species, enterobacter species, proteus species, and pseudomonas aeruginosa. bactericidal end points were determined using a modified steers replicator. ticarcillin was generally two to four times more active against all organisms teste ...	1976	984764
identification of a novel aminonucleoside produced by enterobacter sp. as 2'-amino-2'-deoxyguanosine.		1976	1022341
infection and mortality in captive wild-trapped canvasback ducks.	fungal, bacterial and malarial infections, as well as malnutrition caused heavy mortality in a group of wild-trapped canvasbacks (aythya valisineria) held in 10 x 3 x 2 m open-water pens. deaths occurred between 21 and 158 days after confinement and were associated with infections of aspergillus fumigatus, escherichia coli, staphylococcus sp., streptococcus sp., klebsiella sp., enterobacter sp., and plasmodium sp. infection and mortality was believed to result from reduced resistance associated ...	1976	1255909
simplified scheme for identification of prompt lactose-fermenting members of the enterobacteriaceae.	a brief, simplified scheme involving the spot indole test and colonial morphology was evaluated for genus level identification of prompt lactose-fermenting (plf) members of the enterobacteriaceae. one hundred and ninety-four consecutive, clinically important plf gram-negative rods isolated in a clinical microbiology laboratory were identified by this simplified scheme, as well as by standard biochemical tests, and the api 20e (analytab products, inc., plainview, n.y.) system. in the simplified s ...	1976	794078
electrical impedance measurements in the reading and monitoring of broth dilution susceptibility tests.	electrical impedance changes in the medium were studied during traditional broth dilution tests. tests involved clinical isolates of escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, enterobacter sp., klebsiella, and enterococcus and ten antibiotics. minimal inhibitory concentration (mic) values from overnight visual readings were compared with mic values determined from electrical impedance end points, using inocula of 10(6) organisms per ml. ninety-three percent of the results w ...	1977	883819
studies on 4 c stored frozen-reconstituted red blood cells. i. bacterial growth.	a knowledge of the growth rates of various organisms at the storage temperature of 4 c in the different suspending media used for red blood cells would aid the extension of the thawed storage time of frozen-reconstituted blood beyond the 24 hours allowed by the food and drug administration. knowing these rates, a prediction could be made that the growth rate would be sufficiently slow and the unit (sterile or minimally contaminated) could be given safely after a longer storage period. the studie ...	1977	410123
[behavior of some microorganisms cultivated in the presence of irradiated maize starch].	the bactericidal effect of water soluble radiolysis products of maize starch on escherichia coli cultures declines when the initial population grows. this toxicity varies with the culture environment and the bacterial species: bacillus subtilis, lactobacillus plantarum, streptococcus faecalis, enterobacter sp. moreover, for the eucaryote cell saccharomyces cerevisiae, wild strain or muting "small colonies", only the generating time is altered by the active parts of radiolysis products. the resul ...	1977	410543
possible beta-lactamase activities detectable in infective clinical specimens.	biological beta-lactam antibiotic-inactivating activities were detected in bacteriuria and suppurating pleural fluids. clinical specimens were sterilized with membrane filters and the amounts of ampicillin and/or cephalothin which were being inactivated by 1 ml of each filtrate were determined. in general, filtrates which originally yielded klebsiella sp. tended to show activity against ampicillin; whereas those yielding enterobacter sp. and pseudomonas aeruginosa showed activity against cephalo ...	1977	413821
combined activitiy of clavulanic acid and ticarcillin against ticarcillin-resistant, gram-negative bacilli.	fifty-one clinical isolates of ticarcillin-resistant, gram-negative bacilli were tested for susceptibility to combinations of ticarcillin and clavulanic acid (brl 14151), a potent beta-lactamase inhibitor. minimal inhibitory concentrations (mics) were measured by a microdilution method, and minimal bactericidal concentrations for selected strains were measured by the broth dilution method. ticarcillin mics were >/=128 mug/ml for all and >/=512 mug/ml for 38 (75%) of the strains. thirty-nine stra ...	1978	308792
antimicrobial activity in vitro of cefaclor, a new oral cephalosporin.	the antimicrobial activity of cefaclor, a new orally administered cephalosporin derivative, was studied in vitro against a variety of gram-positive and gram-negative clinical isolates. both penicillin-resistant and penicillin-susceptible strains of staphylococcus aureus were susceptible to cefaclor, with mean mics of 1.44 and 0.93 microgram/ml, respectively. however, the mbc for penicillin-resistant s. aureus was higher than that for the penicillin-susceptible strains. all strains of streptococc ...	1978	624778
the effects of temperature and growth rate on the proportion of unsaturated fatty acids in bacterial lipids.	the effects of temperature and growth rate on the fatty acid composition of the extractable lipids of four mesophilic and three psychotrophic bacteria were examined. two of the mesophiles (escherichia coli and pseudomonas aeruginosa) increased the proportion of unsaturated fatty acids in their lipids with decreasing temperature over their whole growth temperature range. the other mesophiles (enterobacter aerogenes and lactobacillus casei) increased the proportion of unsaturated fatty acids with ...	1978	624935
pharyngeal colonization by gram-negative bacilli in aspiration-prone persons.	we compared the prevalence of gram-negative bacilli in the pharyngeal flora of two groups of patients with a known predilection for gram-negative bacillary pneumonia (chronic alcoholics and diabetics), two other groups of aspiration-prone persons with no known predilection for gram-negative bacillary pneumonia (epileptics and narcotic addicts), and normal control subjects. quantitative cultures of saline gargles showed pharyngeal gram-negative bacilli to be significantly (p less than .05) more p ...	1978	677978
quantitative assessment of bactericidal activities of beta-lactam antibiotics by agar plate method.	quantitative bactericidal activities of beta-lactam antibiotics were determined by the agar plate method. broth cultures, of which the colony-forming units were counted before the study, were inoculated on antibiotic-containing agar plates, utilizing a 10(-3), 10(-2), or 10(-1) dilution or undiluted culture plated with each 0.001-ml calibrated loop. these plates were incubated at 37 degrees c overnight, and the minimal drug concentration at which no bacterial growth was observed on the plates wa ...	1978	102246
semisynthetic cephalosporins. synthesis and structure-activity relationships of 7-(1-pyrryl)- and 7-(1-indolyl)acetamidocephalosporin derivatives.	a series of 1-pyrrole- and 1-indoleacetamido derivatives of 3-heteroaryl-substituted cephalosporins was prepared. the most active compound in the series was 7-[[2-(1-pyrryl)acetyl]amino]-3-[[(1-methyltetrazol-5-yl)thio]-methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6), which showed comparable potency in vitro and in vivo to that of cefazolin, and, in addition, was more potent than cefazolin against enterobacter sp. and providencia stuartii.	1978	722761
comparison of direct and standard antimicrobial disk susceptibility testing for bacteria isolated from blood.	to determine the reliability of early antimicrobial susceptibility testing, we compared the results of direct and standard single-disk diffusion methods for 581 positive blood cultures processed routinely by the clinical microbiology laboratory. the direct procedure differed from the standard one only in that the 0.5 mcfarland inoculum was prepared from 1 ml of turbid broth rather than five isolated colonies from a subculture plate. a major discrepancy in results was defined as a change from sus ...	1979	528681
a comparison of the in vitro activity of a new cephalosporin, cefuroxime, and cephalothin against 810 clinical isolates.	810 strains of eight species: staphylococcus aureus, staphylococcus epidermidis, streptococcus faecalis, escherichia coli, klebsiella sp, enterobacter sp, proteus mirabilis and proteus vulgaris, were tested by the disc diffusion method against cephalothin and cefuroxime. the activity of the two drugs was comparable to s aureus and s epidermidis, and a little in favour of cefuroxime regarding s faecalis. cefuroxime turned out to be superior to cephalothin against the gram negative rods investigat ...	1979	398460
in vitro activity of ly127935.	the activity of ly127935, a beta-lactam antibiotic of novel structure, was studied in vitro against facultative gram-negative bacilli, staphylococcus aureus, and bacteroides fragilis. the strains were recent clinical isolates, many of which were relatively resistant to other antibiotics. ly127935 exhibited striking activity against escherichia coli, klebsiella pneumoniae, enterobacter sp., proteus sp., serratia marcescens, and b. fragilis with median minimum inhibitory concentrations of less tha ...	1979	507785
cefamandole in the treatment of serious bone and joint diseases.	the safety and efficacy of treatment with cefamandole were evaluated in 77 patients (from 33 institutions) with serious bone and joint infections. the antibiotic was given intramuscularly or intravenously in doses ranging from 1.5 to 12 g/day for 6 to 58 days. seventy-three of the 77 patients responded satisfactorily, and 63 (of 70 from whom material for culture was obtainable) patients had a bacteriologic cure. forty-one of 81 isolates were identified as staphylococcus aureus. other pathogens i ...	1980	7010542
clinical trials with cefoperazone in the field of internal medicine in japan.	a total of 466 patients were treated with cefoperazone. the drug was usually administered by drip infusion of 2 to 4 gm/day. therapy was described as markedly effective and moderately effective in 64 of 77 patients (83.1%) treated for urinary tract infections; 253 of 316 patients (80.1%) treated for respiratory infections; 37 of 48 patients (77.1%) treated for liver biliary duct infections; ten of 16 patients (62.5%) treated for septicemia; and seven of nine patients (77.8%) being treated for ot ...	1980	6446392
in vitro activity of a new semisynthetic cephalosporin: cefoperazone.	cefoperazone is a new semisynthetic cephalosporin with excellent antibacterial activity. this study included more than 1,500 clinical isolates whose susceptibility to cefoperazone was determined by minimal inhibitory concentration (mic) and minimal bactericidal concentration (mbc). cefoperazone was highly active against enterobacteriaceae including indolepositive proteus, serratia and enterobacter sp. particularly noteworthy was the high activity of cefoperazone against pseudomonas and acinetoba ...	1980	6446401
nosocomial spread of gentamicin-tobramycin resistance in hospital strains of pseudomonas aeruginosa and enterobacter sp. origin, development and transfer of r plasmids from pseudomonas to enterobacter.	in the medical centre of the university of bratislava the period between 1975 and 1976 was studied with regard to a rather limited use of gentamicin (gen) which was then followed by a period of excessive administration thereof due to a change in the availability of the antibiotic. as a consequence, gen-resistant (genr) pseudomonas appeared in two medical wards, which resistance however, was non-transmissible. a few month later, however, transfer of genr was demonstrated as a co-transfer with oth ...	1980	6784387
[acute infectious endocarditis due to enterobacter sp. related to the presence of a central venous catheter as a complication of diabetic ketoacidosis. report of a case].		1981	6798955
poly(adenylic acid) in small amounts, free or covalently linked to substrate, protects rna from hydrolysis by ribonuclease.	short lengths (18 residues) of poly(a), covalently linked to the 3'-termini of escherichia coli 5 s rrna, induce powerful inhibitions (38-87%) of the activities of rnaases (ribonucleases) from citrobacter sp., enterobacter sp., bovine pancreas, human spleen and human plasma. as the polypurine chain length is extended, enzyme activity declines. furthermore, poly(a) sequences, present only on a small subpopulation of rna, and accounting for less than 1% of total rna, serve to protect all rna, poly ...	1981	6171250
synergistic effect of cephalexin with mecillinam.	in vitro and in vivo synergistic effects of cephalexin and mecillinam against escherichia coli, klebsiella pneumoniae, enterobacter sp., serratia marcescens and proteus sp. were demonstrated and their action mechanism were also discussed. the growth curve after the exposure of cephalexin and mecillinam at the concentrations at which these antibiotics had no effects when given alone showed a decreased of the turbidity and the presence of a bactericidal effect. in experimental infection in mice, t ...	1981	6268594
[antibacterial activities of new cephems against clinically isolated organisms (author's transl)].	the antibacterial activities of cefotaxime (ctx), cefoperazone (cpz), ceftizoxime (czx), cefmenoxime (cmx), latamoxef (lmox), cefotiam (ctm), cefazolin (cez), gentamicin (gm) and cefsulodin (cfs) were investigated. all causative organisms were isolated from patients with urinary tract infections treated in tokai university hospital. the results were as follows. 1) the mics of cmx, ctx, and czx against most of clinically isolated strains of e. coli, k. pneumoniae, indole (-) proteus sp. were 0.1 ...	1982	6285019
[comparison of antimicrobial activity and stability to beta-lactamases of cefoperazone, cefotaxime, lamoxactam and ceftriaxon].	ceftriaxon (ro 13-9904) is a new cephalosporin, whose structure resembles cefotaxime. this study compares the minimal inhibitory concentrations (mic-s) of ceftriaxon, cefoperazone, cefotaxime, lamoxactam and gentamicin against 622 isolates of various enterobacteriaceae, non-fermenters and aeromonas hydrophila. furthermore the minimal bactericidal concentrations (mbc-s) were determined for some organism; additionally destruction of beta-lactamantibiotics in the presence of beta-lactamases was stu ...	1982	6289564
[experimental and clinical studies of cefmenoxime in the field of obstetrics and gynecology].	the study group was organized to evaluate the usefulness of cefmenoxime (cmx) injection, a new synthetic cephalosporin, for the treatment of infections in the field of obstetrics and gynecology. fundamental and clinical studies were made by the society and the following results were obtained. 1. the peak distribution of cmx's mic for e. coli, klebsiella sp., enterobacter sp., bacteroides sp. and peptococcus sp. isolated from obstetrical and gynecological infections with relatively high frequenci ...	1982	6290708
[bacteriological evaluation of netilmicin].	the following results were obtained from the bacteriological evaluations of netilmicin (ntl), a newly developed antibiotic agent, with gentamicin (gm), dibekacin (dkb) and amikacin (amk) as the controls. (1) ntl demonstrated broad antibacterial spectra against both gram-positive and gram-negative bacteria, but its antibacterial potency against streptococci was not very strong among other gram-positive bacteria. (2) in terms of distribution of sensitivity of clinically isolated bacterial strains, ...	1982	6922945
[cefotetan, a new cephamycin antibiotic: in vitro and in vivo antibacterial activities (author's transl)].	cefotetan (ctt) is a new parenteral semisynthetic cephamycin-type antibiotic with a broad antibacterial spectrum against both gram-positive and gram-negative bacteria. against wide varieties of gram-negative bacteria, particularly including indole positive proteus, s. marcescens, enterobacter sp. and c. freundii ctt was more highly active than cefmetazole, cefoxitin and cefazolin. the 50% inhibition doses (id50) of ctt against e. coli, k. pneumoniae, p. mirabilis, indole positive proteus and s. ...	1982	6953260
studies on well water and possible health risks in katsina, nigeria.	well water was sampled from all four major wards in katsina town. all 20 samples taken showed high coliform counts. sixty-five per cent contained greater than or equal to 2400 coliforms per 100 ml while the remainder had counts ranging from 79 to 920. faecal coliforms and non-cholera vibrios were detected in all samples. there was no significant relationship between the coliform counts and the distances of latrines to wells, water table to ground level, slope relationship between wells and latri ...	1983	6833745
the relationship of disc position to zone-of-inhibition size in the disc-agar diffusion test.	one hundred sixteen clinical isolates of enterobacter sp., escherichia coli, klebsiella sp., proteus mirabilis, staphylococcus aureus and s. epidermidis were tested against cefoperazone, cefoxitin, cefamandole and piperacillin by disc-agar diffusion. zones-of-inhibition of discs dropped near the center of the plate were compared with those dropped near the periphery. in 28% of the comparisons the inner and outer zones differed by 2 mm or more. of those, the inner zone was larger 2.5 times more o ...	1983	6876941
isolations of aerobic bacteria from wild desert bighorn sheep (ovis canadensis nelsoni and o. c. mexicana) in arizona.	nasal, pharyngeal, cervical and vaginal swab specimens were obtained from 74 desert bighorn sheep for the purpose of investigating the normal aerobic bacterial flora of wild sheep. a total of 281 isolates was obtained and identified by standard microbiologic tests. one hundred seven of these isolates were gram positive and included bacillus sp. (36%), staphylococcus epidermidis (8%), s. aureus (4%), corynebacterium sp. (diphtheroids, 4%), and streptococcus sp. (48%). gram negative isolates total ...	1983	6887449
examination of the morphology of bacteria adhering to peritoneal dialysis catheters by scanning and transmission electron microscopy.	we examined tenckhoff peritoneal catheters by scanning and transmission electron microscopy to study the morphology of bacterial adherence. two catheters were removed from uninfected patients, three from patients with exit site infections, four from patients with peritonitis, and one from a patient with both exit site infection and peritonitis. infecting organisms included three of staphylococcus aureus and one each of enterobacter sp., staphylococcus epidermidis, achromobacter xylosoxidans, ser ...	1983	6228562
[polymicrobial endocarditis. report of a case and review of the literature].	we describe a case of polimicrobial endocarditis in a patient with congenital aortic stenosis and end-stage renal failure in treatment with steroids and chronic haemodialisis. the blood culture grew e.coli, enterobacter sp, and s.epidermidis. only a few papers in the literature have been devoted to this entity. its frequency seems to be progressively higher. the present case is a good example to talk about the predisponent factors. the review of literature has shown that the occurrence of this e ...	1983	6347104
urinary tract infection and drug-resistant bacteria in different patient populations.	a 1-year survey of the pathogens causing urinary tract infections was conducted in three institutions: a rehabilitation hospital, a general hospital and outpatient clinics. gram-negative rods accounted for 96% of the infections. in the general hospital and the outpatient clinics, escherichia coli was the most prevalent pathogen, while proteus sp. were most prevalent in the rehabilitation hospital. the frequency of drug-resistant isolates was significantly higher in the rehabilitation hospital th ...	1983	6363352
multicenter clinical trials of cefoperazone in japan.	the safety and clinical efficacy of cefoperazone were evaluated at 149 institutions in japan. a total of 979 hospitalized patients were treated with cefoperazone alone for 1,059 infections. in the 984 infections evaluated, there was an overall satisfactory clinical response in 824 (83.7%). cefoperazone was effective in 83.0% of the respiratory tract infections, 84.9% of urinary tract infections, and 89.6% of hepatobiliary tract infections. clinical response was satisfactory in 90% or more of the ...	1984	6394129
[sensitivity to fosfomycin of bacteria isolated at the pitié-salpétrière hospital in 1982 and 1983].	susceptibility of 16 056 strains isolated in 1982 and 1983 to fosfomycin (fos) was tested with mueller-hinton medium and discs 50 micrograms fos + 25 micrograms glucose-6-phosphate (g6p) (cutoff diameter 14 mm). for 3 411 strains, inhibition zone diameters were recorded. almost all e. coli, citrobacter, salmonella and s. aureus were susceptible to fos as well as 70% of serratia, e. cloacae, p. mirabilis and 50% of klebsiella and enterobacter sp. only 27% of p. aeruginosa, 20% of indole positive ...	1984	6431379
inhibitory and bactericidal activities of amifloxacin, a new quinolone carboxylic acid, compared with those of seven other antimicrobial agents.	the activity of amifloxacin, a new quinolone carboxylic acid compound, against 147 strains of microorganisms was studied and was compared with the activities of cinoxacin, trimethoprim, amikacin, and four beta-lactam antimicrobials. the minimal concentration at which 90% of strains were inhibited by amifloxacin was lowest for escherichia coli and klebsiella sp (less than or equal to 0.125 microgram/ml), followed by proteus sp (less than or equal to 0.25 microgram/ml), enterobacter sp and citroba ...	1984	6440708
efficacy of ceftizoxime administered twice daily in hospitalized patients with respiratory tract infections.	the efficacy and safety of ceftizoxime administered twice daily were evaluated in 215 hospitalized patients with documented lower respiratory tract infections. the majority of patients received 1 to 2 gm of ceftizoxime intramuscularly or intravenously every 12 hours; the mean dosage was 2 gm/day, and the mean duration of therapy was 8.9 days. clinical cure was achieved in 204 (95%) of the 215 patients with lower respiratory tract infection. one hundred and thirty-eight patients were both clinica ...	1984	6097357
[clinical effect of cephems: cefoperazone in the treatment of postoperative infections].	cefoperazone (cpz) has a broad antibacterial spectrum against gram-positive, -negative aerobic and anaerobic organisms, it is also highly active against pseudomonas sp. and enterobacter sp. which are hardly susceptible to current cephalosporins. the clinical studies on cpz were performed in postoperative wound infections and abdominal cavity infections, and the following results were obtained. overall clinical effect: the rates of effectiveness were 100% in postoperative wound infections and 71. ...	1984	6481956
in vitro activity of ciprofloxacin, a new carboxyquinoline antimicrobial agent.	the in vitro activity of ciprofloxacin (bay o 9867), a new carboxyquinoline antimicrobial agent, was compared with those of norfloxacin, nalidixic acid, and several other oral and parenteral antimicrobial agents. ciprofloxacin was substantially more active than nalidixic acid or cinoxacin against all gram-negative bacteria tested. virtually all strains of enterobacteriaceae were inhibited by the new drug at concentrations of less than or equal to 0.125 micrograms/ml. ciprofloxacin was more activ ...	1984	6721464
[effect of brl 25000 (clavulanic acid-amoxicillin) on bacterial flora in human feces].	brl 25000 (187.5 and 375 mg tablets), a formulation of cva-k and ampc in the ratio of 1:2, and ampc (as control drug) were administered to healthy volunteers, aged 20 approximately 28 years and weighing 60 approximately 85 kg (68.8 kg, on average). each drug was administered 3 times a day (after meals) for 5 days and the volunteers were separated into 3 groups of 4 subjects each. the effect on the fecal flora was studied before dosage, during administration (day 3 and 5) and day 3 and 5 after th ...	1985	3847525
[enterobacter cloacae and e. aerogenes septicemia: emergence of resistant variants (derepressed cephalosporinase) during treatment with third-generation cephalosporins].	from three patients hospitalised in intensive care units with enterobacter septicaemia (two cases with e. cloacae, and one with e. aerogenes), cefotaxime therapy, alone or in combination with an aminoglycoside, selected variants (r) with increased resistance to beta-lactam antibiotics. the cross-resistance extended to all the beta-lactam antibiotics tested, penicillins and cephalosporins, including third-generation cephalosporins. the crude extracts of uninduced cultures of r variants showed hig ...	1985	3157961
[effects of ks-r1 (ampicillin suppository) and ampicillin oral dosing on fecal flora of children].	a newly developed product, ks-r1 (a suppository containing 250 mg potency of ampicillin (abpc)), was given to 7 children (5 boys and 2 girls) ranging from 4 years and 5 months to 8 years and 10 months in age, 3 times a day (average daily dose, 62.4 mg/kg) for 5 days. as a control, the same amount of abpc dry syrup was given orally to 7 children (4 boys and 3 girls) ranging from 2 years and 8 months to 7 years and 7 months in age, 3 times a day (average daily dose, 55.3 mg/kg) for 5 days. the eff ...	1985	3849603
bacteraemia at the university hospital of the west indies--a report of 222 cases.	a total of 222 cases of septicaemia was recorded at the university hospital of the west indies between june 1982 and june 1983. this gave an overall incidence of 16.1 per 1000 admissions. the 233 bacterial strains isolated comprised 100 gram-positive and 133 gram-negative organisms with klebsiella pneumoniae, streptococcus pneumoniae and staphylococcus aureus being the most frequent. highest rates of septicaemia were recorded in patients less than 1 year and over 50 years of age. septicaemia cau ...	1985	3891869
[laboratory and clinical studies on cefminox].	laboratory and clinical studies were performed on cefminox (cmnx, mt-141), a new cephamycin antibiotic, and results were as follows. antimicrobial activities. mics of cmnx against various clinical isolates were determined with the inoculum size of 10(6) cells/ml. percentages of strains susceptible to 12.5 micrograms/ml or less were 4% for s. aureus, 0% for e. faecalis, 100% for e. coli, 81% for k. pneumoniae, 3% for enterobacter sp., 18% for s. marcescens, 90% for p. mirabilis, 88% for indole-po ...	1985	3930782
susceptibility testing with disc diffusion for new cephalosporins: pre-diffusion revisited.	the purpose of the present study was to investigate the effect of 20-hour pre-diffusion, i.e. placing the antibiotic-containing discs on the agar for 20 hours prior to inoculation, as compared to direct diffusion, i.e. placing the discs on the agar immediately after inoculation, for the newer 3. generation cephalosporins as represented by ceftazidime and ceftriaxone. regression lines (zone sizes vs. inhibitory concentrations, as measured by plate-dilution) were constructed for three groups of ba ...	1986	3090857
[clinical and bacteriological study of o-demethylfortimicin a sulfate in urinary infection].	o-demethyl-fortimicin-a-sulfate (odmf) is a semisynthetic derivative of fortimicin-a with increased in vitro activity especially against pseudomonas aeruginosa. this study was designed to determine the efficacy of odmf in the treatment of uti and to evaluate the in vitro susceptibility of bacteria isolated from the urine of patients to odmf as compared to tobramycin (to), gentamicin (ge) and amikacin (ak). in 28 hospitalized patients with acute uti, odmf (free base) in a dose of 2 to 5 mg/kg was ...	1986	3534728
in vitro activity of ro 15-8074 and ro 19-5247, two orally administered cephalosporin metabolites.	the activity of two iminomethoxy aminothiazoly cephalosporins, ro 15-8074 and ro 19-5247, was compared with that of other beta-lactams against a total of 491 bacterial strains. both were highly active (mic for 90% of the strains tested [mic 90], less than or equal to 2 micrograms/ml) against the majority of the members of the family enterobacteriaceae, haemophilus influenzae, neisseria spp., and streptococcus pneumoniae, being at least 16-fold more active than cephalexin and 8-fold more active t ...	1986	3729361
brl-36650: in vitro studies and assessment of serum bactericidal activity after single-dose administration in volunteers.	ten healthy volunteers received 1 g of brl-36650, a new formamido-penicillin derivative, given by intravenous infusion over 15 min. levels in serum were measured microbiologically 30, 60, and 120 min after the start of the 15-min infusion and were (mean +/- standard deviation) 102.7 +/- 28.4, 59.7 +/- 11.5, and 9.6 +/- 1.9 mg/liter, respectively. a total of 10 strains each of escherichia coli, klebsiella pneumoniae, serratia spp., and enterobacter spp. and 14 strains of pseudomonas aeruginosa we ...	1986	3755314
[effect of cefminox on bacterial flora in human adult feces].	cefminox (cmnx), a new cephamycin, was administered by one shot intravenous injection twice daily with a dose of 1,000 mg each time for 5 days to seven healthy male volunteers whose ages ranged from 21 to 28 years (mean: 25 years) and body weights were from 60 to 92 kg mean: 72 kg). the effect of the drug on fecal bacterial flora was investigated and the concentrations of the drug in feces were measured on 5th day before the treatment, on 0, 3rd, and 5th day (the final day of the treatment) duri ...	1986	3761549
[effect of s6472 and cefaclor on bacterial flora in adult human feces].	s6472 is a mixture of cefaclor (ccl) granules with gastric-soluble coating and those with enteric-soluble coating at the ratio (in potency) of 4 to 6. with administration of this formulation, a prolonged blood level of ccl is obtained. s6472 and ccl were administered orally to 19 healthy male volunteers between 20 and 27 years of age (mean: 23 years) weighing between 51 and 80 kg (mean: 64.7 kg). four subjects were given 2 capsules and 5 subjects were given 4 capsules each containing 187.5 mg of ...	1986	3702058
premarket evaluation of ids rapid ss/u system for identification of urine isolates.	a total of 170 fresh clinical urine isolates were tested with a premarket configuration of the rapid ss/u system (innovative diagnostic systems, inc., atlanta, ga.), a qualitative micromethod for the identification of selected organisms commonly isolated from urine specimens. results were compared with those obtained with conventional methods of identifying gram-positive isolates and with the automicrobic system (vitek systems, inc., hazelwood, mo.), utilizing gram-negative identification cards ...	1987	3539997
microbiology of the female genital tract.	patients who contract genital tract infections are predominantly young, are otherwise healthy, and generally respond well to treatment for bacterial infections. these infections are most commonly polymicrobial in etiology, with several noteworthy exceptions. often there is an inciting event such as childbirth, surgical intervention, pregnancy termination or intrauterine contraceptive device insertion. with treatment, prognosis for cure is excellent; however, sequelae such as recurrent infections ...	1987	3548376
differences in antimicrobial susceptibilities of clinical isolates in saudi arabia and the united states.	in vitro antimicrobial susceptibilities of 3,530 clinical isolates at king faisal specialist hospital and research center (kfsh), in riyadh, saudi arabia, were compared with those of 11,041 bacterial isolates at two hospitals of comparable size in the united states. the gram-negative bacteria, especially escherichia coli, proteus-morganella group, enterobacter sp, serratia marcescens, and pseudomonas aeruginosa were generally more resistant to ampicillin, carbenicillin, cephalosporin, gentamicin ...	1987	3586042
occurrence of multiple antibiotic resistance and r-plasmids in gram-negative bacteria isolated from faecally contaminated fresh-water streams in hong kong.	the bacterial populations of six freshwater streams in populated areas of the hong kong new territories were studied. there is considerable faecal contamination of these streams, with coliform counts as high as 10(5) c.f.u./ml and the contaminating organisms show a high prevalence of antibiotic resistance and multiple resistance. with direct plating of water samples onto antibiotic-containing media, an average of 49% of the gram-negative bacteria were ampicillin-resistant, 3% chloramphenicol-res ...	1987	3595747
[statistical studies on bacteria isolated from urinary tract infections (report 4)].	the statistics and drug sensitivity tests of bacterial florae isolated from the urinary tract in 1983 and 1984 were reviewed. of the 2,222 strains isolated from outpatients, 593 (26.7%) were gram positive cocci, 21.4% were e. coli, 11.3% were enterococcus, 10.4% were proteus sp., 10.0% were p. aeruginosa, 5.6% were alcaligenes sp., 4.2% were s. epidermidis and the rest were others. of the 507 strains isolated from hospitalized patients, 107 (33.5%) were gram positive cocci, 20.3% were enterococc ...	1987	3687632
[effect of norfloxacin on bacterial flora in human feces].	norfloxacin (nflx), a synthetic oral antibacterial agent of quinolone carboxylic acid, was given orally for 5 full days at a dose of 200 mg, three times daily after each meal to healthy normal men with ages between 22 and 25 years weighing 53.0 to 84.0 kg (average 67.0 kg). the actual regimen followed was that the drug was administered twice after lunch and supper on the first day of dosing, and once after breakfast on the last day of dosing. on the 5th day before the start of dosing, on the fir ...	1987	3694785
[susceptibility of clinical bacterial isolates to aztreonam].	in vitro activities of 7 antimicrobial agents against organisms (474 strains) isolated from patients with various infections in ehime university hospital from may to july 1986 were investigated. summarized results are as follows: 1. aztreonam (azt) showed potent activities against escherichia coli, citrobacter sp., klebsiella pneumoniae, serratia marcescens, proteus sp., pseudomonas aeruginosa and haemophilus influenzae. 2. antimicrobial activities of azt were especially superior against proteus ...	1987	3121888
susceptibility of gentamicin sensitive and resistant gram negative bacilli to ceftazidime.	the in-vitro activity of ceftazidime was compared with other third-generation cephalosporins and gentamicin against 409 isolates. ceftazidime was the most active agent against enterobacter sp., proteus mirabilis, serratia sp., proteus sp. and pseudomonas aeruginosa. it was less active against escherichia coli and klebsiella than moxalactam and cefotaxime but more active than cefoperazone. against gentamicin resistant e. coli, klebsiella, enterobacter and p. aeruginosa, ceftazidime was more activ ...	1987	3124067
a morphological study of the action of equine anti-lipopolysaccharide plasma on gram-negative bacteria.	three strains of gram-negative bacteria--one each of escherichia coli, klebsiella pneumoniae and enterobacter sp.--were treated with anti-lipopolysaccharide hyperimmune equine plasma (anti-lps) or non-immune control plasma and examined by scanning electronmicroscopy. within a few minutes of treatment with anti-lps, bacteria were agglutinated. evidence of cell membrane destruction was observed shortly thereafter and total cell disintegration and disruption occurred within 1-2 h. in contrast, non- ...	1987	3309324
[treatment of urinary infection with cephadroxyl (pharmachem)--microbiological and clinical research].	the bacteria isolated from the urine of renal patients were tested for sensitivity towards cephadroxyl (pharmachem) and other beta-lactam antibiotics--altogether 654 examinations were made. it was established that the gram-positive bacteria (excluding the enterococcus) are sensitive towards cephadroxyl. from the gram negative bacteria e. coli, klebsiella sp., enterobacter sp., p. mirabilis, citrobacter sp. showed the greatest sensitivity towards cephadroxyl, while the indole positive proteus wer ...	1987	3433735
the in vitro activity of the combination of cefotaxime and hre 664.	cefotaxime (ctx) and hre 664 (a novel penem antibiotic) possess complementary in vitro properties. differences can be observed in their antibacterial spectra, their beta-lactamase stability and -inhibition, and their affinity to penicillin-binding proteins. these differences suggested that combinations of the cephalosporin and the penem antibiotic would be advantageous and should be studied. the fractional inhibitory concentration values of checkerboard studies confirmed that ctx and hre 664 act ...	1987	3429341
a comparative study of the sensitivity of bacteria of various origin to ofloxacin.	the sensitivity of 6 antimicrobials (chloramphenicol, tetracycline, ampicillin, cephalothin, trimethoprim/sulfamethoxazole and ofloxacin) was tested on 174 bacteria isolated from three sources: 60 from wounds, 84 from urine and 30 from bronchial excretions. hospital-borne bacteria were compared to those of non-hospital origin for their susceptibility. consecutively, pseudomonas aeruginosa (24 strains), escherichia coli (58), klebsiella sp. (13), enterobacter sp. (3), citrobacter sp. (3), enteroc ...	1987	3474082
bacterial bioabsorption of nickel from industrial cooling water.	three bacterial strains tolerant to the presence of 100 mg litre(-1) nickel ions were isolated from a water reclamation system. each organism was tested for ability to accumulate nickel at the above-mentioned concentration. the organism capable of maximum nickel accumulation was identified as an enterobacter sp. and intracellular nickel deposition by this microorganism was determined using energy dispersive x-ray analysis (edax) and transmission electron microscopy. a metal-staining technique fo ...	1987	15092681
species-related differences in the incidence of gram-negative bacteria isolated from the cloaca of clinically normal psittacine birds.	cloacal swabs from 506 clinically normal psittacine birds of 22 species were aerobically cultured for bacteria and yeasts. in 45 (9%) samples, no microbial organisms were recovered. gram-positive bacteria were recovered from 474 (91%) samples. the incidences of gram-negative bacteria and yeasts were: escherichia coli 157 (31%), enterobacter sp. 21 (4%), klebsiella sp. 3 (0.6%), pseudomonas sp. 4 (0.8%), and yeasts 26 (5%). differences were noted in the recovery rate of e. coli among the various ...	1988	3289533
efficacy and safety of cefpirome (hr810).	sixty adult patients with suspected systemic bacterial infections were treated with cefpirome 1 g or 2 g twice daily for 5-22 days. forty-seven patients were evaluable for clinical efficacy. diagnoses in evaluable patients were urinary tract infections (20), pneumonia (10), soft tissue infections (17), and bone and joint infections (4); four patients had two infections each. nine patients were bacteraemic and all were cured; the responsible bacteria were escherichia coli (6), streptococcus pneum ...	1988	3204079
[non-pigmented serratia: utility of hydrolysis of tween 80 in its identification].	the ability of serratia sp. to hydrolyze tween 80 and the usefulness of this test for differentiating it from other gram negative bacilli was studied, comparing it with the capacity of production of dnasa by the same strains using the o-toluidine blue method. the total number of strains assayed was 88. the sensitivity obtained was 83.9% and specificity 91.3%, with a positive predictive value of 83.9% and a negative predictive value of 91.2%. using this method to differentiate only non-pigmented ...	1988	3175019
in vitro and in vivo antibacterial activity of ky-109, a new orally active cephalosporin.	the in vitro and in vivo antimicrobial potencies of ky-109, a pro-drug of ky-087, were compared with those of amoxicillin, cephalexin (cex), and cefaclor (ccl). the following results were obtained. ky-087, which is the active form of ky-109, had broad antimicrobial spectrum against gram-positive and gram-negative organisms, but showed low antimicrobial activity against enterobacter sp., serratia, and pseudomonas sp. the antimicrobial activities of ky-087 against clinically isolated gram-positive ...	1988	3417567
osteomyelitis secondary to trauma or infected contiguous soft tissue.	nonhematogenous osteomyelitis (nho) occurred in 24 pediatric patients (ages 8 months to 18 years; median, 14 years; 23 male) admitted from 1980 to 1985. predisposing factors included compound fracture (12), deep decubiti (4) and foot puncture (3). infection involved tibia (7), foot bones (6), proximal femur (3) and ulna (2). patients presented with drainage (64%), pain or tenderness (44%) and fever (32%) lasting for 1 to 180 days (median, 10 days). in 24% both white blood cell count and erythroc ...	1988	2893333
[laboratory and clinical studies of norfloxacin in respiratory tract infections].	norfloxacin (nflx), a new quinolone antibacterial agent, was investigated for its antibacterial activity and clinical efficacy on respiratory tract infections. the results obtained are summarized as follows: 1. antibacterial activities were evaluated against 127 strains of various bacteria isolated from clinical sources. mic80's of this drug were: against staphylococcus aureus and streptococcus pyogenes 1.56 micrograms/ml; haemophilus influenzae 0.05 microgram/ml or less; and klebsiella sp. and ...	1988	3367509
[aerobic and anaerobic bacterial flora of crural ulcers].	in a group of 600 patients treated in the metropolitan dermatological hospital in warsaw bacteriological examination were carried out of swabs from the untreated crural ulcers. in 95% of these cultures growth of pathological aerobic organisms was obtained. coagulase-positive staphylococci (st. aureus) and gram-negative bacteria (pseudomonas aeruginosa, proteus vulgaris, enterobacter sp and e. coli) prevailed. in 27% of cases the cultured strains were resistant to the generally available antibiot ...	1988	3268941
[gram-negative bacteria isolated from wound infections and their susceptibility to various antibiotics].	in this study gram negative pathogens isolated from wound infections and antibiotic susceptibilities of these bacteria were evaluated by using sceptor (bblr) microdilution system. according to the our results, it was observed that enterobacter sp. were found to be major causative agent with the ratio of 22.67%. the isolated gram negative bacteria have been found to be highly resistant to the most of the antibiotics except amikacin.	1989	2487464
[the rapid identification of e. coli by the detection of 3 enzymes].	232 isolates of gram-negative, oxidase-negative bacteria, isolated from various samples of different animal species, were tested with help of rapidec coli for the production of beta-glucuronidase, beta-galactosidase and indole. the test correctly identified 164 of 175 e. coli strains (sensitivity 93.7%) and correctly indicated that 57 of 57 isolates of the family enterobacteriaceae (7 citrobacter sp., 18 enterobacter sp., 16 klebsiella sp., 10 proteus sp., 2 providencia sp. and 4 salmonella sp.) ...	1989	2497726
urinary tract infection.	over two years, 9892 mid-stream urine samples from patients attending the aga khan university hospital, karachi were cultured. significant bacterial growth was seen in 23.5% samples. further identification of these organisms revealed 40% of e. coli, 16% pseudomonas aeruginosa, 11% klebsiella aerogenes, 5.0% enterobacter sp., 13% proteus sp., 4.0% serratia liquifaciens, 1.0% acinetobacter sp., 3.0% citrobacter sp., 4.0% enterococci, 0.5% staphylococcus aureus. results of sensitivity tests perform ...	1989	2504948
aerobic and anaerobic microbiology of biliary tract disease.	a retrospective analysis of the experiences of two military hospitals over 4 years in the recovery of organisms from biliary tract specimens was done. bacterial growth was obtained in 123 bile specimens. aerobic and facultative bacteria only were present in 59 specimens (48%), aerobic bacteria only were present in 4 specimens (3%), and mixed anaerobic and aerobic or facultative bacteria were present in 60 specimens (49%). of 286 isolates recovered, 216 were aerobic or facultative (1.8 per specim ...	1989	2584384
ciprofloxacin in patients with bacteremic infections. the spanish group for the study of ciprofloxacin.	the efficacy and safety of ciprofloxacin in the treatment of 68 episodes of bacteremia were studied. patients were treated intravenously (30 cases), orally (13 cases), or with sequential intravenous/oral therapy (25 cases). intravenous doses ranged from 200 to 400 mg per day and oral doses ranged from 1,000 to 1,500 mg per day. according to the criteria of mccabe and jackson, 39 cases had nonfatal and 29 had ultimately fatal underlying diseases. the clinical condition of patients at the start of ...	1989	2589366
efficacy and safety of higher-dose intravenous ciprofloxacin in severe hospital-acquired infections.	in an open prospective study, 54 patients in an interdisciplinary, operative, anesthesiologic intensive care unit were treated with intravenous ciprofloxacin for life-threatening infections. secondary nosocomial pneumonias were the predominant infection in most patients. a total of 88 causative pathogens were isolated from 50 patients. the most commonly isolated organism was pseudomonas aeruginosa; serratia marcescens, staphylococcus aureus, and enterobacter sp. were also isolated. pathogens cou ...	1989	2589385
[in vitro susceptibility to a new antimicrobial agent (imipenem) of pathogens isolated from inpatients at various centers].	imipenem is a beta lactam antibiotic, a highly potent new carbapenem with broad antibacterial spectrum. to test the "in vitro" efficacy of this antimicrobial agent in pathogens more frequent in several medical centers in brazil, susceptibility testing with 10 mcg imipenem disks and, or corresponding mic were carried out with 1231 recent isolates of 41 different bacterial species, obtained mainly from hospitalized patients in 5 different medical centers of the cities of s. paulo, rio de janeiro a ...	1989	2617012
[the rapid identification of escherichia coli using bactident e. coli].	165 (93.7%) of 175 e. coli strains isolated from various materials of different animal species were correctly identified as e. coli with help of commercially available bactident e. coli (e. merck, d-6100 darmstadt). further 52 strains of the family of enterobacteriaceae (2x providencia sp., 2x salmonella sp., 7 citrobacter sp., 9 proteus sp., 15 klebsiella sp., 17 enterobacter sp.) were correctly not identified as e. coli by this test. bactident e. coli is a suitable test for rapid identificatio ...	1989	2647078
[clinical experience of chemotherapy with cefmetazole for severe infections accompanying malignant hematological disorders].	we made an attempt to treat with cefmetazole (cmz) 25 patients who developed severe infectious diseases while suffering with granulocytopenia associated with the treatment of malignant hematological disorders. 1. determination of bacteriological efficacy while 20 strains were isolated and identified from 15 patients, no significant bacteria were detected in 9 patients. isolates obtained were: 5 strains of enterococcus faecalis, 3 strains of haemophilus influenzae, 2 strains of staphylococcus epi ...	1989	2664248
[frequency of germ isolation from urinary infections in community practice; their sensitivity to 7 antibiotics including a combination of amoxicillin and clavulanic acid. evaluation on 1611 samples].	a multicenter study including 10 outpatient private laboratories (hospital laboratories excluded) was carried out in france. 1,611 urines samples from patients with uti were collected during the forth trimester of 1987. the most frequently recovered pathogens were: e. coli (71%), proteus mirabilis (9%), staphylococcus coagulase (6%), klebsiella (6%), enterobacter (2%). other sorts (streptococcus d, proteus sp, pseudomonas aeruginosa, enterobacter sp) were infrequent (less than 1%). the sensitivi ...	1989	2674870
evaluation of numerical analysis of sds-page of protein patterns for typing enterobacter cloacae.	twenty cultures comprising 13 clinical isolates of enterobacter cloacae from two hospitals, the type and another reference stain of e. cloacae and the type strains of four other enterobacter sp. and of escherichia coli, were characterized by one-dimensional sodium dodecyl sulphate-polyacrylamide gel electrophoresis (sds-page) of whole-cell proteins. the protein patterns were highly reproducible and were used as the basis of a numerical analysis which divided the clinical isolates into nine clear ...	1989	2680547
ticarcillin/clavulanate in the treatment of severe peritonitis.	a prospective study was performed on 50 consecutive patients with secondary peritonitis. all patients received ticarcillin/clavulanate 5.2 g three times daily as initial antibiotic therapy. in 30 patients a primary perforation was found in the gastro-intestinal tract and 20 had post-operative peritonitis. in two thirds of the patients a diffuse peritonitis was found which affected the whole abdomen. thirty-six patients underwent one or two laparotomies and 11 patients had more than three laparot ...	1989	2691475
in vitro activity of tigemonam against urinary tract pathogens.	tigemonam's in vitro activity was compared with that of aztreonam, cefotaxime, gentamicin, and norfloxacin. thirty-two strains of pseudomonas and 960 strains of enterobacteriaceae were studied using the agar dilution method (including escherichia coli, klebsiella pneumoniae, klebsiella oxytoca, enterobacter sp., serratia marcescens, proteus mirabilis, proteus vulgaris, morganella morganii, and salmonella enterica). tigemonam displayed good activity against enterobacteriaceae. minimum inhibitory ...	1989	2809699
in vitro studies of tigemonam: a comparison of the minimum inhibitory and minimum bactericidal concentrations (mic vs mbc).	the in vitro activity of tigemonam, a new oral monobactam, was studied with special attention to minimum inhibitory concentrations (mics) and minimum bactericidal concentrations (mbcs). against 250 clinical isolates, it inhibited 100% of escherichia sp., klebsiella sp., serratia sp., citrobacter sp., providencia sp., proteus sp., morganella sp., aeromonas sp., yersinia sp., shigella sp., and haemophilus sp. at 0.5 mg/l or less. with 1 mg/l, 75% of enterobacter sp. were inhibited; however, three ...	1989	2809701