Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| oviposition deterrent activity from the ethanolic extract of pongamia pinnata, coleus forskohlii, and datura stramonium leaves against aedes aegypti and culex quinquefaciatus. | mosquitoes are responsible for spread of many diseases than any other group of arthropods. diseases such as malaria, filariasis, dengue hemorrhagic fever (dhf), and chikunguinya are real threat to mankind. in the present study, ethanolic extracts of leaves of pongamia pinnata, coleus forskohlii, and datura stramonium were evaluated for oviposition deterrent activity against aedes aegypti and culex quinquefasciatus. the oviposition deterrent tests of ethanolic extract of pongamia pinnata, coleus ... | 0 | 21120036 |
| the positive inotropic-acting forskolin, a potent adenylate cyclase activator. | forskolin is a positive inotropic-acting and blood pressure lowering agent which was isolated from the indian plant coleus forskohlii. in isolated heart tissue, forskolin activates a membrane bound adenylatecyclase and a cytoplasmic camp-dependent protein kinase to a much higher degree than does isoprenaline. this activation does not require the hormone receptor. in isolated and electrically stimulated left guinea pig atria, the adenylate-cyclase activation by forskolin is the prerequisite for t ... | 1981 | 7197529 |
| pharmacological studies on coleonol, a hypotensive diterpene from coleus forskohlii. | coleus spp. have been used in aurvedic medicine for heart diseases, spasmodic pain, painful micturition and convulsions. the pharmacological properties of coleonol, a diterpene, isolated from coleus forskohlii were investigated. its predominant effect is to lower the blood pressure of anaesthetised cat and rat as well as of the spontaneously hypertensive rat due to relaxation of the vascular smooth muscle. in small doses it has a positive inotropic effect on isolated rabbit heart as well as on c ... | 1981 | 7193263 |
| forskolin: a potential antimetastatic agent. | forskolin, a diterpene from the roots of an indian plant, coleus forskohlii, is a potent platelet aggregation inhibitor and has been examined for its effects on (a) tumor-induced human platelet aggregation and (b) pulmonary tumor colonization in mice. these studies employed a subline of b16 murine melanoma, b16-f10 (highly metastatic to lungs). forskolin (2 microm) strongly inhibits the melanoma cell-induced human platelet aggregation. a single dose of forskolin (82 micrograms/mouse) administere ... | 1983 | 6686215 |
| structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. | forskolin (7 beta-acetoxy-8,13-epoxy-1 alpha, 6 beta, 9 alpha-trihydroxylabd-14-en-11-one), a diterpene from the indian plant coleus forskohlii, activates cyclic amp generating systems in a number of mammalian tissues in a rapid and reversible fashion. derivatives of forskolin have been tested for their ability to stimulate membrane adenylate cyclase from rat brain and rabbit heart, as well as cyclic amp generation in guinea pig brain vesicular preparations, a model system for intact cells. deri ... | 1983 | 6681845 |
| the action of forskolin on muscle cells is modified by hormones, calcium ions and calcium antagonists. | forskolin, a drug isolated from the indian plant coleus forskohlii, exerts its actions on cells by directly activating the catalytic subunit of adenylatecyclases. the primary effect on heart muscles is the positive inotropic one, at higher forskolin concentrations, an acceleration of the pacemaker activity can be observed. external ca2+ is required for this augmentation of contraction, verapamil, prenylamine and tetrodotoxin depress these effects. the action of forskolin and digitalis glycosides ... | 1983 | 6316992 |
| forskolin stimulation of acid and pepsinogen secretion by gastric glands. | isolated gastric glands were used to investigate the action of forskolin, a novel diterpene extracted from the indian plant coleus forskohlii. forskolin was found to stimulate both acid formation and pepsinogen secretion. the stimulation was rapid, reversible and dose dependent with an ed50 of approx. 1 microm. the efficacy of forskolin was similar to that of more commonly used secretagogues, e.g. histamine, carbachol, cyclic amp derivatives. the responses to forskolin were not inhibited by any ... | 1983 | 6299372 |
| forskolin lowers intraocular pressure by reducing aqueous inflow. | forskolin is a diterpene derivative of the plant coleus forskohlii that stimulates adenylate cyclase activity without interacting with cell surface receptors. forskolin lowers the intraocular pressure of rabbits, monkeys, and humans. in rabbits, net aqueous humor inflow decreases, outflow facility remains unchanged, and ciliary blood flow increases. tolerance to the intraocular pressure lowering effect did not occur in rabbits after topical doses given every 6 hr for 15 days. in vitro forskolin ... | 1984 | 6538189 |
| forskolin stimulation of naphthylamidase in guinea pig thyroid sections detected with a cytochemical bioassay. | forskolin, from the roots of the indian medicinal plant coleus forskohlii, has recently been shown to be a potent stimulator of adenylate cyclase in many systems, including endocrine tissues such as the thyroid gland. we describe forskolin activation of beta-naphthylamidase activity in guinea pig thyroid tissue using the cytochemical bioassay (cba) for thyroid stimulators. this cba is the most sensitive bioassay for tsh and lats-b currently available, being able to detect stimulation by doses as ... | 1985 | 2984870 |
| inhibition of ige-mediated release of histamine and peptide leukotriene from human basophils and mast cells by forskolin. | forskolin, a diterpene compound isolated from the roots of coleus forskohlii, activates adenylate cyclase in membranes from a variety of mammalian tissues. we found that forskolin (10(-7) to 3 x 10(-5) m) caused a concentration-related inhibition of ige-mediated release of histamine and peptide leukotriene c4 (ltc4) from human basophils and lung mast cells. there was a significant linear correlation between the per cent inhibition of histamine and ltc4 release from both cell types. however, in b ... | 1987 | 2432900 |
| relaxant effects of forskolin on guinea pig tracheal smooth muscle. | we investigated the relaxant effects of forskolin, a diterpene derivative isolated from the roots of coleus forskohlii, on guinea pig airway smooth muscle by measuring the isometric tension of tracheal smooth muscle in vitro and transcutaneous po2 during the histamine inhalation test (hit) in vivo. forskolin (10(-9)-10(-5) m) caused dose-dependent relaxant effects on resting tone and on leukotriene c4 (10(-7) m)-, leukotriene d4 (10(-7) m)-, and carbachol (3 x 10(-6) m)-induced contraction of tr ... | 1987 | 3041128 |
| significance of plasma adenosine in the antiplatelet activity of forskolin: potentiation by dipyridamole and dilazep. | forskolin, a plant (coleus forskohlii) diterpene, inhibits adp-induced (human: ic50, 2.3 +/- 1.0 microm; rat: ic50, 1.2 +/- 0.5 microm) and collagen-induced (human: ic50, 2.4 +/- 1.2 microm; rat: 0.6 +/- 0.2 microm) platelet aggregation in human and rat platelet-rich plasma (prp). human blood levels of adenosine (ado) are low (100-300 nm) as compared to levels in rat plasma (7.55 +/- 0.51 microm). ado is a natural antiplatelet and vasodilatory agent produced by vascular endothelium, heart and ot ... | 1989 | 2749584 |
| the effect of adenylate cyclase stimulation on endocochlear potential in the guinea pig. | forskolin, a diterpene extracted from coleus forskohlii, is potentially an important tool for studying the modulation of ionic currents by camp because it stimulates adenylate cyclase in a variety of cells. we studied the effect of forskolin on cochlear potentials and found that its perfusion of the scala vestibuli (sv) to a concentration more than 10(-5) m and the scala tympani (st) to more than 10(-4) m produced a reversible elevation of the endocochlear potential (ep) in a dose-dependent mann ... | 1990 | 2310543 |
| insulin and glucagon releasing activity of coleonol (forskolin) and its effect on blood glucose level in normal and alloxan diabetic rats. | colenol, a diterpenoid isolated from the roots of coleus forskohlii stimulates the release of insulin and glucagon from the islets both in vitro and in vivo. colenol-stimulated release of glucagon from islets in vitro is much more pronounced as compared to that of insulin. glucose concentration of 5.6 mm in the medium is required for the colenol stimulation of insulin release. feeding of coleonol to alloxan diabetic rats cause 36.5% increase in blood glucose level as compared to alloxan diabetic ... | 1991 | 1650516 |
| production of forskolin by axenic coleus forskohlii roots cultivated in shake flasks and 20-l glass jar bioreactors*. | root cultures of coleus forskohlii briq. were initiated from primary callus or iba-treated suspension cultures and maintained on gamborg's b5 medium containing 1 mg/l iba. transformed root cultures were established by infecting surface-sterilized leaves with agrobacterium rhizogenes strain 15834. transformation was confirmed by mannopine detection. these cultures displayed the typical characteristics of hairy root cultures, with the sole exceptions of slow growth in hormone-free medium and accel ... | 1992 | 17226482 |
| forskolin synthesis in in vitro cultures of coleus forskohlii briq transformed with agrobacterium tumefaciens. | agrobacterium tumefaciens mediated tumor tissue and shooty teratomas of coleus forskohlii were cultured in vitro. forskolin was detected in tumorous callus (0.002%), rhizogenic callus (0.011%) and root cultures (0.014%), but not in shooty teratomas. forskolin synthesis and accumulation in tumorous c. forskohlii cultures may permit the elucidation of diterpene metabolism in this species. | 1996 | 24178612 |
| development of elisa-analysis methods for the quantification of bioactive natural products in plants, phytomedicines and in humans or similar. | in the course of a program in developing new elisa-methods for the quantification of bioactive natural products in plants, phytomedicines and animals in a μg and ng scale, monoclonal antibodies against various natural products of medicinal and analytical importance have been developed. the ratio of hapten to bovine serum albumin (bsa) in an antigen conjugate was determined by matrix-assisted laser desorption/ionization (maldi) of mass spectrometry. a hybridoma secreting monoclonal antibodies (ma ... | 1998 | 23195990 |
| monoclonal antibodies against naturally occurring bioactive compounds. | the ratio of hapten to bovine serum albumin (bsa) in an antigen conjugate was determined by matrix-assisted laser desorption/ionization (maldi) tof mass spectrometry. a hybridoma secreting monoclonal antibody (mab) was produced by fusing splenocytes immunized with an antigen-bsa conjugate with hat-sensitive mouse myeloma cells. the cross-reaction of anti-forskolin antibodies with 7-deacetyl forskolin was 5.6%. a very small cross-reaction appeared with other derivatives. the full measuring range ... | 1999 | 19003120 |
| establishment of forskolin yielding transformed cell suspension cultures of coleus forskohlii as controlled by different factors. | suspension cultures derived from gall calli which were obtained following infection with agrobacterium tumefaciens (c58) were established in coleus forskohlii. cell line selection following single cell cloning or cell aggregate cloning was carried out to select cell lines capable of fast growth and for producing high level of forskolin. a fast growing cell line (gso-5/7) thus selected was found to accumulate 0.021% forskolin in 42 days. the effect of cultural conditions on cell growth was studie ... | 2000 | 10784298 |
| natural therapies for ocular disorders, part two: cataracts and glaucoma. | pathophysiological mechanisms of cataract formation include deficient glutathione levels contributing to a faulty antioxidant defense system within the lens of the eye. nutrients to increase glutathione levels and activity include lipoic acid, vitamins e and c, and selenium. cataract patients also tend to be deficient in vitamin a and the carotenes, lutein and zeaxanthin. the b vitamin riboflavin appears to play an essential role as a precursor to flavin adenine dinucleotide (fad), a co-factor f ... | 2001 | 11302779 |
| antibacterial and anti-inflammatory activities of some plants used for medicinal purposes in kenya. | aqueous, hexane and methanol extracts of 12 plant species, traditionally used in kenya for treatment of ailments of infectious and/or inflammatory nature were screened for in vitro antibacterial and anti-inflammatory activities. antibacterial activity was tested using the agar diffusion method while anti-inflammatory activity was tested using the cyclooxygenase (cox-1) assay. all the antibacterial activity was against gram-positive bacteria with nine plant species showing some activity against s ... | 2003 | 12787952 |
| antispasmodic effect of the essential oil of plectranthus barbatus and some major constituents on the guinea-pig ileum. | the effects of the plectranthus barbatus essential oil (pbeo) at concentrations ranging form 1 to 300 microg/ml and some major constituents, i. e., alpha-pinene, myrcene and caryophyllene in the ratio and amount found in the oil, were studied on the contractility of the guinea-pig ileum. pbeo decreased the basal tonus of the ileum with a maximal response (r (max); % of k (+)-contraction) of 62.7 +/- 3.8 % compared with 36.6 +/- 4.5 % inhibition achieved with alpha-pinene and 68 +/- 2.6 % with pa ... | 2003 | 14750021 |
| molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from coleus forskohlii briq. | isopentenyl diphosphate (ipp), a common biosynthetic precursor to the labdane diterpene forskolin, has been biosynthesised via a non-mevalonate pathway. geranylgeranyl diphosphate (ggpp) synthase is an important branch point enzyme in terpenoid biosynthesis. therefore, ggpp synthase is thought to be a key enzyme in biosynthesis of forskolin. herein we report the first confirmation of the ggpp synthase gene in coleus forskohlii briq. | 2004 | 15550168 |
| effects of coleus forskohlii on fat storage in ovariectomized rats. | the antiobesity effects of coleus forskohlii were investigated in ovariectomized (ovx) rats. eight-week-old female wistar rats were assigned to four groups: a sham-operated group fed the control diet (mf, sham-m) ; an ovx-m group fed the control diet; a sham-operated group fed the control diet containing 50 g/kg of coleus forskohlii extract (sham-c) ; and an ovx-c group fed the control diet containing 50 g/kg of coleus forskohlii extract. the body weight, adipose tissues, and cell diameter were ... | 2005 | 15863977 |
| effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. | abstract : purpose : this study investigated the effects of coleus forskohlii (cf) on body composition, and determined the safety and efficacy of supplementation. methods : in a double blind and randomized manner, 23 females supplemented their diet with forsleantrade mark (250 mg of 10% cf extract, (n = 7) or a placebo [p] (n = 12) two times per day for 12-wks. body composition (dexa), body weight, and psychometric instruments were obtained at 0, 4, 8 & 12 weeks of supplementation. fasting blood ... | 2005 | 18500958 |
| screening of tanzanian medicinal plants for anti-candida activity. | candida albicans has become resistant to the already limited, toxic and expensive anti-candida agents available in the market. these factors necessitate the search for new anti-fungal agents. | 2006 | 16571139 |
| a forskolin derivative, fsk88, induces apoptosis in human gastric cancer bgc823 cells through caspase activation involving regulation of bcl-2 family gene expression, dissipation of mitochondrial membrane potential and cytochrome c release. | fsk88, a forskolin derivative, was extracted and purified from cultured tropical plant roots, coleus forskohlii. our previous studies have demonstrated that fsk88 can inhibit hl-60 cell proliferation and induce the differentiation of hl-60 cells to monocyte macrophages. in this study, we showed that fsk88 can induce apoptotic death of human gastric cancer bgc823 cells in a dose- and time-dependent manner. results showed that fsk88-induced apoptosis was accompanied by the mitochondrial release of ... | 2006 | 16889987 |
| antifungal activity of some coleus species growing in nilgiris. | the in vitro antifungal activity of solvent extracts of coleus forskohlii, coleus blumei and coleus barbatus were compared by testing against some pathogenic fungi like aspergillus niger, aspergillusfumigatus, aspergillus ruantii, proteus vulgaris and candida albicans. the petroleum ether extract of coleus forskohlii and coleus barbatus exhibited significant antifungal activity against all the selected organisms. the extracts of coleus blumei did not show any significant antifungal activity agai ... | 2006 | 22557230 |
| identification of a forskolin-like molecule in human renal cysts. | renal cyst enlargement is increased by adenosine camp, which is produced within mural epithelial cells. in a search for modulators of camp synthesis cyst fluids from 18 patients with autosomal dominant or recessive polycystic kidney disease (pkd) were analyzed, and in 15 of them, a stable lipophilic molecule that increased camp levels, stimulated transepithelial chloride and fluid secretion, and promoted the proliferation of human cyst epithelial cells was characterized. with the use of hplc-mas ... | 2007 | 17251383 |
| inhibition of the gastric h+,k+ -atpase by plectrinone a, a diterpenoid isolated from plectranthus barbatus andrews. | this work assessed the mechanism underlying the antisecretory gastric acid effect of plectranthus barbatus andrews (lamiaceae) and active constituents. popularly known as "false-boldo", this plant is used in brazilian folk medicine to treat gastrointestinal and hepatic ailments. the plant aqueous extract (ae) and isolated compounds were assayed in vivo in pylorus-ligated mice, and in vitro on acid secretion measured as [(14)c]-aminopyrine ([(14)c]-ap) accumulation in rabbit gastric glands and ga ... | 2007 | 17166678 |
| two minor diterpene glycosides and an eudesman sesquiterpene from coleus forskohlii. | two new labdane diterpene glycosides, forskoditerpenosides a, b (1, 2) and a new eudesmane sesquiterpene, 4beta,7beta,11-enantioeudesmantriol (3), were isolated from the ethanol extract of the whole plant of coleus forskohlii. their structures and stereochemistry were elucidated by extensive spectroscopic analysis and chemical methods. the structure of compound 3 was confirmed by x-ray diffraction. this is the first report about the occurrence of glycosides derived from the kind of labdane diter ... | 2007 | 17329875 |
| in vitro antimicrobial assay of plants used in traditional medicine in bukoba rural district, tanzania. | plants used in traditional medicine in bukoba rural district in tanzania were evaluated for their in vitro antimicrobial activities. plant materials from eight plant species (harungana madagascariensis (lam) poir., jatropha curcas l., lantana trifolia l., plectranthus barbatus andr., pseudospondias microcarpa engl., psorospermum febrifugum spach, teclea nobilis del. and vernonia adoensis [warp.] sl) were collected based on ethnomedical information provided by traditional herbal practitioners. re ... | 2007 | 20161920 |
| free amino acids in botanicals and botanical preparations. | numerous studies were carried out about aminoacidic composition of vegetable proteins, but information about the free amino acid pool and the role of these substances is very incomplete. the aim of this paper was to contribute to the scarce knowledge concerning the composition of free amino acids in botanicals and botanical preparations widely used as food, in dietary supplements, and in pharmaceutical products. this work studied the composition of free amino acids, identified the major componen ... | 2008 | 18576976 |
| diterpenes from coleus forskohlii (willd.) briq. (labiatae). | three new minor labdane diterpene glycosides, forskoditerpenoside c, d, and e (1-3), and a novel labdane diterpene forskoditerpene a (4) were isolated from the ethanol extract of the whole plant of coleus forskohlii. their structures and relative stereochemistry were elucidated on the basis of extensive spectroscopic analyses including 1d-, 2d-nmr, and hr-esi-ms experiments. compounds 1-3 showed an unusual 8,13-epoxy-labd-14-en-11-one glycoside pattern. they showed relaxative effects on isolated ... | 2008 | 18175974 |
| inhibition of tumor cell proliferation by coleon c. | coleon c (6,11,12,14,16-pentahydroxyabieta-5,8,11,13-tetraen-7-one), extracted from coleus forskohlii briq., was investigated for its anti-tumor activity on eight human tumor cell lines (95-d, a375, hela, a431, mkn45, bel7402, lovo and hl60) and two normal ones (293, l02) by mtt and colony-forming assay in vitro. the results indicated that a375 was the most sensitive of all the cell lines. hoechst 33258 staining showed fragmentation and condensation of chromatin. dna ladder assay indicated the f ... | 2008 | 18467252 |
| in vitro skin diffusion study of pure forskolin versus a forskolin-containing plectranthus barbatus root extract. | an in vitro skin diffusion study of pure forskolin (1) versus a 1-containing plectranthus barbatus root extract (p. barbatus extract) in hairless guinea pig skin and human skin in a flow-through diffusion cell system was conducted and is being reported for the first time. both topical agents were formulated in a solution of 70% ethanol and 30% propylene glycol (v/v). the results showed that forskolin can be delivered through the stratum corneum and that the flux of this compound was enhanced whe ... | 2009 | 19281221 |
| anti-hiv diterpenes from coleus forskohlii. | various extracts of the aerial parts of coleus forskohlii (labiatae) were prepared and evaluated at their non cytotoxic concentration against hiv-1 nl4-3. chloroform, ethyl acetate and n-butanol extracts showed 45.6, 66.5 and 37.7% inhibition of hiv, respectively in cem-gfp cells infected with hiv-1(nl4-3) at 5 microg/ml. four diterpenes, 1-deoxyforskolin, 1,9-dideoxyforskolin, forskolin and isoforskolin were isolated from the chloroform extract and tested against the virus. six semi-synthetic d ... | 2009 | 19831022 |
| coleusin factor exerts cytotoxic activity by inducing g0/g1 cell cycle arrest and apoptosis in human gastric cancer bgc-823 cells. | coleusin factor (cf), a kind of diterpenoids, is isolated and purified from the root of a chinese tropical plant coleus forskohlii by our laboratory. our previous studies have demonstrated that cf significantly inhibits growth in some kinds of cancer cell lines. here, we found that cf remarkably inhibited growth in human gastric cancer bgc-823 cells by decreasing cell proliferation, inducing g(0)/g(1) cell cycle arrest and apoptosis. cf also decreased the mitochondrial membrane potential in bgc- ... | 2010 | 21093146 |
| effect of selected antiasthmatic plant constituents against micro organism causing upper respiratory tract infection. | most exacerbations of asthma can be proven to be associated with bacterial infections and there is scientific evidence that frequent respiratory infections particularly bacterial infections provoke asthma attack. considering these facts different plant extracts and phytoconstituents with proven anti asthmatic property had been selected for screening anti microbial activity in in-vitro models. in the present study, coleus forskohlii willd. extract (10% forskolin), piper longum l. extract (20% pip ... | 2010 | 22557357 |
| Coleus forskohlii extract induces hepatic cytochrome P450 enzymes in mice. | Coleusforskohlii root extract (CFE) is popular for use as a weight loss dietary supplement. In this study, the influence of standardized CFE containing 10% active component forskolin on the hepatic drug metabolizing system was investigated to evaluate the safety through its drug interaction potential. Male ICR mice were fed AIN93G-based diets containing 0-5% CFE or 0.05% pure forskolin for 2-3weeks. Intake of two different sources of 0.5% CFE significantly increased the relative liver weight, to ... | 2011 | 22178802 |
| anti-hiv activity of indian medicinal plants. | acquired immunodeficiency syndrome patients face great socio-economic difficulties in obtaining treatment. there is an urgent need for new, safe, and cheap anti-hiv agents. traditional medicinal plants are a valuable source of novel anti-hiv agents and may offer alternatives to expensive medicines in future. various medicinal plants or plant-derived natural products have shown strong anti-hiv activity and are under various stages of clinical development in different parts of the world. the prese ... | 2011 | 21365365 |
| isoforskolin pretreatment attenuates lipopolysaccharide-induced acute lung injury in animal models. | isoforskolin was isolated from coleus forskohlii native to yunnan in china. we hypothesize that isoforskolin pretreatment attenuates acute lung injury induced by lipopolysaccharide (endotoxin). three acute lung injury models were used: situ perfused rat lung, rat and mouse models of endotoxic shock. additionally, lipopolysaccharide stimulated proinflammatory cytokine production was evaluated in human mononuclear leukocyte. in situ perfused rat lungs, pre-perfusion with isoforskolin (100, and 200 ... | 2011 | 21272678 |
| function of plectranthus barbatus herbal tea as neuronal acetylcholinesterase inhibitor. | this study aims to determine the function of plectranthus barbatus (lamiaceae) herbal tea as inhibitor of the brain acetylcholinesterase (ache) activity. to accomplish this objective the herbal tea as well as its main component, rosmarinic acid were administered to laboratory animals (rats) and the effect on the brain ache activity was evaluated. the study of the herbal tea metabolites in the plasma and also in the brain was undertaken. the herbal water extract was administered intragastrically ... | 2011 | 21779558 |
| anticonvulsant activity of extracts of plectranthus barbatus leaves in mice. | plectranthus barbatus is a medicinal plant used to treat a wide range of disorders including seizure. however, the anticonvulsant activity of this plant has not been studied in depth. we therefore sought to evaluate the anticonvulsant activity of a hydroalcoholic extract of p. barbatus leaves on seizures induced by strychnine sulphate (2.0 mg/kg) and pilocarpine (600 mg/kg) in mice. the extract was administered orally at 1, 10, 30, and 100 mg/kg. we report that the p. barbatus extract had marked ... | 2012 | 21716675 |
| in vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants used in the traditional arabian peninsular region. | worldwide particularly in developing countries, a large proportion of the population is at risk for tropical parasitic diseases. several medicinal plants are still used traditionally against protozoal infections in yemen and saudi arabia. thus the present study investigated the in vitro antiprotozoal activity of twenty-five plants collected from the arabian peninsula. | 2012 | 22520595 |
| in vitro antiplasmodial activity of selected luo and kuria medicinal plants. | drug resistance in malaria is a recurring subject that threatens public health globally. there is an urgent need to seek new antimalarial agents. this study seeking new antimalarials from medicinal plants is guided by ethnobotany. | 2012 | 23041700 |
| in vitro conservation of twenty-three overexploited medicinal plants belonging to the indian sub continent. | twenty-three pharmaceutically important plants, namely, elaeocarpus spharicus, rheum emodi, indigofera tinctoria, picrorrhiza kurroa, bergenia ciliata, lavandula officinalis, valeriana wallichii, coleus forskohlii, gentiana kurroo, saussurea lappa, stevia rebaudiana, acorus calamus, pyrethrum cinerariaefolium, aloe vera, bacopa monnieri, salvia sclarea, glycyrrhiza glabra, swertia cordata, psoralea corylifolia, jurinea mollis, ocimum sanctum, paris polyphylla, and papaver somniferum, which are a ... | 2012 | 22593711 |
| adaptive expression of host cell wall degrading enzymes in fungal disease: an example from fusarium root rot of medicinal coleus. | quantity of extracellular proteins and activities two cell wall degrading enzymes pectinase and cellulase were determined in the culture filtrate of fusarium solani, the causal organism of root rot of coleus forskohlii. substitution of carbon source in the medium with either pectin or carboxymethyl cellulose led to the increased production of extracellular proteins by the fungus. pectinase and cellulase activity in the culture filtrate was detected only when the growth medium contained substitut ... | 2013 | 24517025 |
| a review on botanical species and chemical compounds with appetite suppressing properties for body weight control. | as obesity has reached epidemic proportions, the management of this global disease is of clinical importance. the availability and popularity of natural dietary supplements for the treatment of obesity has risen dramatically in recent years. the purpose of this paper was to review the effect of commonly available over the counter plant-derived supplements used to suppress appetite for obesity control and management. the data were obtained from the electronic databases pubmed, springerlink, googl ... | 2013 | 23666454 |
| study of the interference between plectranthus species essential oils from brazil and aminoglycosides. | plectranthus is one of the most representative genera of lamiaceae family. in this study, the essential oils from plectranthus amboinicus, plectranthus ornatus, and plectranthus barbatus were investigated for their chemical composition and antimicrobial and modulatory activities. the major components found were carvacrol (54.4%-p. amboinicus) and eugenol (22.9%-p. ornatus e 25.1%-p. barbatus). in vitro antimicrobial activity was conducted against escherichia coli, proteus vulgaris, bacillus cere ... | 2013 | 23662150 |
| synergy between glomus fasciculatum and a beneficial pseudomonas in reducing root diseases and improving yield and forskolin content in coleus forskohlii briq. under organic field conditions. | root rot and wilt, caused by a complex involving fusarium chlamydosporum (frag. and cif.) and ralstonia solanacearum (smith), are serious diseases affecting the cultivation of coleus forskohlii, a crop with economic potential as a source of the medicinal compound forskolin. the present 2-year field experiments were conducted with two bioinoculants (a native pseudomonas monteilii strain and the exotic arbuscular mycorrhizal (am) fungus glomus fasciculatum) alone and in combination under organic f ... | 2013 | 22648372 |
| traditional botanical knowledge of artisanal fishers in southern brazil. | this study characterized the botanical knowledge of artisanal fishers of the lami community, porto alegre, southern brazil based on answers to the following question: is the local botanical knowledge of the artisanal fishers of the rural-urban district of lami still active, even since the district's insertion into the metropolitan region of porto alegre? | 2013 | 23898973 |
| in vitro antiprotozoal activity of abietane diterpenoids isolated from plectranthus barbatus andr. | chromatographic separation of the n-hexane extract of the aerial part of plectranthus barbatus led to the isolation of five abietane-type diterpenes: dehydroabietane (1); 5,6-didehydro-7-hydroxy-taxodone (2); taxodione (3); 20-deoxocarnosol (4) and 6α,11,12,-trihydroxy-7β,20-epoxy-8,11,13-abietatriene (5). the structures were determined using spectroscopic methods including one- and two-dimensional nmr methods. compounds (1)-(3) and (5) are isolated here for the first time from the genus plectra ... | 2014 | 24823881 |
| eco-friendly synthesis of silver and gold nanoparticles with enhanced bactericidal activity and study of silver catalyzed reduction of 4-nitrophenol. | the present study reports a simple and robust method for synthesis of silver and gold nanoparticles using coleus forskohlii root extract as reducing and stabilizing agent. stable silver nanoparticles (agnps) and gold nanopoarticles (aunps) were formed on treatment of an aqueous silver nitrate (agno3) and chloroauric acid (haucl4) solutions with the root extract. the nanoparticles obtained were characterized by uv-visible spectroscopy, transmission electron microscopy (tem), x-ray diffraction (xr ... | 2014 | 24681320 |
| a comparison of the anti-staphylococcus aureus activity of extracts from commonly used medicinal plants. | resurgences of staphylococcus aureus infection continue globally, with antibiotic resistance increasing dramatically, making these infections more difficult to treat. s. aureus epidemics impose public health threats, and economic burdens on health care costs worldwide, presenting challenges modern medicine struggles to control. | 2014 | 24635487 |
| cyclic amp synergizes with butyrate in promoting β-defensin 9 expression in chickens. | host defense peptides (hdp) have both microbicidal and immunomodulatory properties. specific induction of endogenous hdp synthesis has emerged as a novel approach to antimicrobial therapy. cyclic adenosine monophosphate (camp) and butyrate have been implicated in hdp induction in humans. however, the role of camp signaling and the possible interactions between camp and butyrate in regulating hdp expression in other species remain unknown. here we report that activation of camp signaling induces ... | 2014 | 24141182 |
| volatile compounds of lamiaceae exhibit a synergistic antibacterial activity with streptomycin. | bacterial infections cause thousands of deaths in the world every year. in most cases, infections are more serious because the patient is already weakened, and often, the bacteria are already resistant to the antibiotics used. counterparting this negative scenario, the interest in medicinal plants as an alternative to the synthetic antimicrobial drugs is blossoming worldwide. in the present work, we identified the volatile compounds of ethanol extracts of melissa officinalis, mentha sp., ocimum ... | 2014 | 25763039 |
| assessing the chemical composition and antimicrobial activity of essential oils from brazilian plants-eremanthus erythropappus (asteraceae), plectrantuns barbatus, and p. amboinicus (lamiaceae). | the chemical composition and antimicrobial activity of essential oils obtained from three brazilian plant species-leaves and branches of eremanthus erythropappus (asteraceae), leaves of plectranthus barbatus, and leaves of p. amboinicus (lamiaceae)-were determined. analysis by gc/ms and determination of kovats indexes both indicated δ-elemene (leaves-42.61% and branches-23.41%) as well as (-)-α-bisabolol (leaves-24.80% and stem bark-66.16%) as major constituents of e. erythropappus essential oil ... | 2015 | 25970043 |
| forskolin: genotoxicity assessment in allium cepa. | forskolin, a diterpene, 7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one (c22h34o7) isolated from coleus forskohlii, exerts multiple physiological effects by stimulating the enzyme adenylate cyclase and increasing cyclic adenosine monophosphate (camp) concentrations. forskolin is used in the treatment of hypertension, congestive heart failure, eczema, and other diseases. a cytogenetic assay was performed in allium cepa to assess possible genotoxic effects of forskolin. forskolin was t ... | 2015 | 25726172 |
| investigation of urban ethnoveterinary in three veterinary clinics at east zone of são paulo city, brazil. | urban ethnoveterinary should be further explored because of its value as it resists conventional medical care. in addition, the comparison between the resources used by ethnoveterinary and ethnopharmacology should be investigated in depth, increasing the availability of new bioactive potential in human and veterinary medicines. this project aimed to determine whether plants are used in the health care of dogs and/or cats in urban area and to compare its uses with other ethnoveterinary and ethnop ... | 2015 | 26205641 |
| variation of karyotype and nuclear dna content among four species of plectranthus l' héritier, 1788 (lamiaceae) from brazil. | plectranthus is a genus which includes species of ornamental and medicinal potential. it faces taxonomic problems due to aggregating species previously belonging to the genus coleus, a fact that has contributed to the existence of various synonymies. the species plectranthus amboinicus, plectranthus barbatus, plectranthus grandis and plectranthus neochilus are included in this context. some authors consider plectranthus barbatus and plectranthus grandis as synonyms. the present work was carried ... | 2015 | 26753074 |
| metabolic engineering of synechocystis sp. pcc 6803 for production of the plant diterpenoid manoyl oxide. | forskolin is a high value diterpenoid with a broad range of pharmaceutical applications, naturally found in root bark of the plant coleus forskohlii. because of its complex molecular structure, chemical synthesis of forskolin is not commercially attractive. hence, the labor and resource intensive extraction and purification from c. forskohlii plants remains the current source of the compound. we have engineered the unicellular cyanobacterium synechocystis sp. pcc 6803 to produce the forskolin pr ... | 2015 | 26133196 |
| gc-ms characterisation and biological activity of essential oils from different vegetative organs of plectranthus barbatus and plectranthus caninus cultivated in north italy. | essential oils (eos) from the roots, stems and leaves of plectranthus barbatus (a) and plectranthus caninus (b), cultivated in north italy, were obtained by steam distillation and chemically characterised by gas chromatography-mass spectrometry. the highest yields were obtained from roots (268.15 and 673.60 mg/kg from a and b), followed by leaves (64.34 and 26.65 mg/kg) and stems (19.76 and 18.63 mg/kg). a total of 128 structures were identified in a and 121 in b. fe(++) chelating and antiradica ... | 2015 | 25277251 |
| extraction and elemental analysis of coleus forskohlii extract. | coleus forskohlii willd. is a popular traditional medicine used since ancient times for treatment of heart diseases, abdominal colic and respiratory disorders. | 2015 | 26130934 |
| eugenol, α-pinene and β-caryophyllene from plectranthus barbatus essential oil as eco-friendly larvicides against malaria, dengue and japanese encephalitis mosquito vectors. | mosquito-borne diseases represent a deadly threat for millions of people worldwide. eco-friendly mosquitocides are a priority. in ayurvedic medicine, plectranthus species have been used to treat heart disease, convulsions, spasmodic pain and painful urination. in this research, we evaluated the acute toxicity of essential oil from plectranthus barbatus and its major constituents, against larvae of the malaria vector anopheles subpictus, the dengue vector aedes albopictus and the japanese encepha ... | 2016 | 26518773 |
| evaluation of the use of ocimum suave willd. (lamiaceae), plectranthus barbatus andrews (lamiaceae) and zanthoxylum chalybeum engl. (rutaceae) as antimalarial remedies in kenyan folk medicine. | crude extracts from the leaves of ocimum suave willd (lamiaceae) and the root barks of plectranthus barbatus andrews (lamiaceae) and zanthoxylum chalybeum engl. (rutaceae) were studied to ascertain the ethnopharmacological standing of their antimalarial usage in kenyan folk medicine. | 2016 | 26705665 |
| total biosynthesis of the cyclic amp booster forskolin from coleus forskohlii. | forskolin is a unique structurally complex labdane type diterpenoid used in the treatment of glaucoma and heart failure based on its activity as a cyclic amp booster. commercial production of forskolin relies exclusively on extraction from its only known natural source, the plant coleus forskohlii, in which forskolin accumulates in the root cork. here we report the discovery of five cytochrome p450s and two acetyltransferases which catalyze a cascade of reactions converting the forskolin precurs ... | 2017 | 28290983 |
| control of biofilm forming clinically important bacteria by green synthesized zno nanoparticles and its ecotoxicity on ceriodaphnia cornuta. | zinc oxide nanoparticles were synthesized using the aqueous leaf extracts of plectranthus barbatus (plb-zno nps) and characterized by uv-visible spectroscopy, xrd, ftir, sem and eds. uv-visible spectra recorded the absorbance peak of plb-zno nps at 343 nm. sem analyses showed the spherical shape of plb-zno nps with the particle size between 30 and 60 nm. plb-zno nps exhibited antibacterial and antibiofilm activity against gram positive bacillus subtilis at all tested concentrations. in contrast, ... | 2017 | 28330748 |