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pseudomonas maltophilia, an alcaligenes-like species. 196114449786
[on the isolation of pseudomonas maltophilia from clinical examination material]. 196514272024
an immune-type agglutination of mouse spermatozoa by pseudomonas maltophilia. 19684881448
diagnostic criteria for differentiation of pseudomonads pathogenic for man.to determine the most useful diagnostic characters for the differentiation of pseudomonads pathogenic for man, including pseudomonas maltophilia (alcaligenes bookeri), p. stutzeri (bacillus denitrificans), p. pseudomallei (malleomyces pseudomallei), and apyocyanogenic strains of p. aeruginosa, a comparative examination was made of 58 strains of these bacilli for their morphological and biochemical characteristics. it was concluded that the criteria for differentiating these bacteria are type of ...19684879213
pseudomonas maltophilia infections in man. 19695766111
bacteremia with and without meningitis due to yersinia enterocolitica, edwardsiella tarda, comamonas terrigena, and pseudomonas maltophilia. 19705278130
detection of arginine dihydrolase in nonfermentative gram-negative bacteria by use of thin-layer chromatography.thin-layer chromatography was used to detect the presence of the arginine dihydrolase system in nonfermentative gram-negative bacteria. the test was positive for the fluorescent pseudomonads as well as pseudomonas maltophilia, whereas other pseudomonas sp., mima, and herellea were negative. this procedure can be completed in a few hours and may be useful in the clinical laboratory.19715137584
acute mastoiditis following pseudomonas maltophilia infection: case report. 19724337404
[characterization of pseudomonas maltophilia]. 19724553285
[influence of temperature on the gentamicin effect in pseudomonas maltophilia]. 19734695876
isolation of a transducing phage forming plaques on pseudomonas maltophilia and pseudomonas aeruginosa. 19734199939
occurrence of branched-cahin hydroxy fatty acids in pseudomonas maltophilia.three branched-chain hydroxy acids not previously reported in other bacteria were found in extracts from saponified whole cells of pseudomonas maltophilia. on the basis of evidence from mass spectrometry, infrared spectroscopy, and gas chromatographic procedures, they were identified as 2-hydroxy-9-methyldecanoic acid, 3-hydroxy-9-methyldecanoic acid, and 3-hydroxy-11-methyldodecanoic acid. these acids appeared to be tightly bound to other cellular components since they were not extracted from l ...19734712564
production of volatile nitrogenous compounds from the degradation of streptomycin by pseudomonas maltophilia.ammonia, methylamine, and pyridine were detected in broth filtrates of a streptomycin-degrading strain of pseudomonas maltophilia during growth on streptomycin as a sole carbon and nitrogen source. ammonia and methylamine, quantitatively measured by conversion to chromophores with picryl sulfonic acid, were found to accumulate in broth, whereas pyridine concentration increased in the early stages of streptomycin degradation and then decreased as the degradation of the antibiotic neared completio ...19734752939
pseudomonas maltophilia endocarditis after replacement of the mitral valve: a case study. 19734758059
[pseudomonas maltophilia infections]. 19744839507
synergistic effect of combinations of sulfamethoxazole, trimethoprim, and colistin against pseudomonas maltophilia and pseudomonas cepacia.eighteen strains of pseudomonas maltophilia and eight strains of p. cepacia were tested for susceptibility to sulfamethoxazole, trimethoprim, and colistin in different combinations. a synergistic effect was found against most of the strains.19744143759
[pseudomonas maltophilia as an agent of infection in man (author's transl)]. 19744155214
regulation of extracellular protease secretion in pseudomonas maltophilia.cells grown in minimal medium and harvested in late exponential phase secreted extracellular protease linearly when suspended at high density in fresh medium. if the cells were suspended with 0.2% (wt/vol) yeast extract and no additional carbon source, the rate of exoenzyme production was increased several-fold. when pyruvate, l-malate, succinate, or alpha-ketoglutarate was added, repression of exoenzyme secretion was observed. the most effective repressor was alpha-ketoglutarate. these compound ...19751158851
in vitro susceptibility of pseudomanas cepacia and pseudomonas maltophilia to trimethoprim and trimethoprim-sulfamethoxazole.our earlier studies had shown that the two pseudomonads, pseudomonas cepacia and pseudomonas maltophilia, were organisms that were highly resistant to most antibiotics. the present study was undertaken to determine the susceptibility of these bacteria to trimethoprim and the trimethoprim-sulfamethoxazole combination which has been used with apparent success in treating infections caused by these pseudomonads. all 51 strains of p. cepacia were inhibited by 2 mug or less of trimethoprim per ml, wh ...19751155926
competitive effects of intestinal microflora on vibrio cholerae in gnotobiotic mice.the coexistence of vibrio cholerae and several intestinal bacteria was determined in gnotobiotic mice. the bacteria tested included a bacteroides sp, clostridium difficile, clostridium perfringens type a, 2 separate isolates of escherichia coli, 2 different lactobacilli, 2 separate isolates of proteus mirabilis, pseudomonas maltophilia, and streptococcus faecalis. each species of bacteria became established and was recovered repeatedly from the stools during the studies. no single strain or spec ...1975807775
purification and properties of a serine protease from pseudomonas matophilia.the extracellular protease of pseudomonas maltophilia was partially purified by ammonium sulfate precipitation and chromatography on sephadex g-75 and bio-rex 70. gel electrophoresis revealed minor impurities. the enzyme exhibited the following properties: (i) molecular weight, 35,000; (ii) a see article; 10.8; (iii) isoelectric point, 9.3; (iv) ph optimum, 10.0; (v)s20, w equal 3.47. the enzyme was rapidly inactivated by ethylenediaminetetracetate, but activity could be partially restored with ...1975234950
meningitis caused by pseudomonas maltophilia.a case of meningitis caused by pseudomonas maltophilia is described, which was unusual in that it appeared to lack the predisposing factors commonly associated with this organism. attention is drawn to the difficulties which may be encountered in the identification of ps. maltophilia.19751165296
peptide utilization by pseudomonas putida and pseudomonas maltophilia.pseudomonas putida assimilates peptides and hydrolyses them with intracellular peptidases. amino acid auxotrophs (his, trp, thr or met) grew on a variety of di- and tripeptides up to twice as slowly as with free amino acids. pseudomonas putida has separate uptake systems for both dipeptides and oligopeptides (three or more residues). although the dipeptide system transported a variety of structurally diverse dipeptides it did not transport peptides having either unprotonatable n-terminal amino g ...19761255131
intracellular peptide hydrolysis by pseudomonas putida and pseudomonas maltophilia.amino acids liberated by peptidase hydrolysis of di- and oligopeptides by pseudomonas putida were measured by trinitrobenzenesulphonate assay and high voltage electrophoresis or paper chromatography followed by ninhydrin spray. intact bacteria or periplasmic contents released by lysozyme treatment did not hydrolyse peptides. subcellular fractionation showed that glycylmethionine peptidase activity was cytoplasmic. this enzyme had a km of 2 mm, and was stimulated fivefold by i mm-co2+. crude pept ...19761255132
bacterial variants: etiologic agent in crohn's disease?bacterial variants of pseudomonas maltophilia and pseudomonas-like bacteria were recovered from tissues removed during the surgical treatment of three successive patients with crohn's disease and from one patient with clinical and pathological features of both crohn's disease and chronic ulcerative colitis. bacterial variants were not cultured from colonic specimens of one patient with classical features of chronic ulcerative colitis and two patients with adenocarcinoma of the colon. the finding ...1976780185
infection with pseudomonas maltophilia hospital outbreak due to contaminated disinfectant.between august, 1973, and may, 1974, pseudomonas maltophilia was isolated from 63 patients in the king edward memorial hospital for women, subiaco, western australia. primary cultures were obtained mainly from specimens of urine from adults, and from intraarterial catheter tips and umbilical swabs from neonates. in most cases the organism appeared to be a contaminant, but in seven it was responsible for infection. the source of the organism was deionized water used for diluting savlon concentrat ...19761004317
[characterization of telluric bacteria attributable to pseudomonas maltophilia].the taxonomic position of some telluric non-fermenting gram-negative bacteria collected into a phenon representing about a quarter of the soil isolates by an earlier numerical analysis is specified. the shapiro--chargaff coefficient determined by thermal-transition curves of the dna and their hybridization by nitrocellulose filters method show a close affinity with pseudomonas maltophilia.1977907912
[pseudomonas maltophilia in cerebrospinal fluid samples. isolation, identification and antibiograms of 4 strains]. 1977897286
pseudomonas maltophilia bacteremia associated with a prolapsed mitral valve.a 53-year-old man had had recurrent episodes of transient visual loss, malaise and a heart murmur. blood cultures repeatedly grew pseudomonas maltophilia, a frequent opportunistic pathogen, and echocardiogram documented mitral-valve prolapse. the risk of bacterial endocarditis is stressed.1977879107
presence of 3-o-methyl-l-xylose in the lipopolysaccharide of pseudomonas maltophilia n.c.t.c. 10257.3-o-methyl-l-xylose was isolated from whole cells of pseudomonas maltophilia n.c.t.c. 10257. the sugar is a component of lipopolysaccharide from which a polysaccharide also containing l-rhamnose and l-xylose was released by mild acid hydrolysis. 3-o-methyl-l-xylose was absent from five other strains of ps. maltophilia and one strain of pseudomonas geniculata.1977869917
pseudomonas maltophilia infection in an abattoir worker.a case of infection with pseudomonas maltophilia is described. the clinical record and bacteriological findings are reported, and the possible aetiology is discussed.1977865359
[study of 2 cases of pseudomonas maltophilia meningitis observed in senegal]. 1977589735
specific gonadotropin binding to pseudomonas maltophilia.binding of 125i-labeled human chorionic gonadotropin to pseudomonas maltophilia is dependent on time, temperature, and ph and the binding to this procaryotic species is hormone-specific and saturable. the equilibrium dissociation constant is 2.3 x 10(-9) m. there are no cooperative interactions between binding sites (hill coefficient, 1.05). the number of sites is estimaated as 240 fmol/100 mug of protein. nacl and kcl, at concentrations from 1 to 10 mm, have no effect on binding. divalent catio ...1977265583
induction and catabolite repression of glucosidases in pseudomonas maltophilia.intracellular alpha-and beta-glucosidases were induced in cell suspensions of pseu-domonas maltophilia by maltose or cellobiose, and the synthesis of these enzymes was sensitive to apparent catabolite repression by alpha-ketoglutarate.197716345233
metabolism of glycosides by pseudomonas maltophilia.a study of the abilities of 23 strains of pseudomonas maltophilia to hydrolyze synthetically-prepared and naturally-occurring glycosides is presented. direct detection of liberated aglycones was used to determine hydrolysis of the five most-commonly-used glycosides (amygdalin, arbutin, esculin, onpg (o-nitrophenyl-beta-d-galactoside), and salicin). the capabilities of the strain for acid production from 17 glycoside substrates were also determined using a medium designed to minimize the producti ...1978250499
pseudomonas maltophilia causing heroin-associated infective endocarditis.the association of pseudomonas maltophilia endocarditis in three patients with recent history of intravenous drug abuse is reported. all three patients had abnormal heart valves (two prosthetic and one rheumatic). a prominent characteristic of this uncommon pathogen is its in vitro resistance to the commonly used antimicrobials. cure was achieved in all three cases. in two cases, synergistic antibiotic combinations were used. in one case, plasmid-mediated resistance to amikacin sulfate (amikan, ...1978718316
aminoglycoside 6'-n acetyltransferase production by an isolate of pseudomonas maltophilia. 1978690050
[clinical and bacteriological study on pseudomonas maltophilia (author's transl)]. 1978642210
pseudomonas maltophilia pseudosepticemia.during a 17 month period, 25 hospitalized adult patients had blood cultures reported as positive for pseudomonas maltophila. review of the hospital records suggested that these were contaminants and that blood for coagulation studies and for cultures that were subsequently positive had been drawn simultaneously. the source of contamination appeared to be black-top evacuated collection tubes used for coagulation studies in adults. cultures of the liquid anticoagulant tubes yielded a pure growth o ...1978637055
search by immunofluorescence for antigens of rotavirus, pseudomonas maltophilia, and mycobacterium kansasii in crohn's disease.crohn's-disease tissue was tested by indirect immunofluorescence for antigens of rotavirus, pseudomonas maltophilia, and mycobacterium kansasii. no reactions were obtained with anti-serum to p. maltophilia and m. kansasii, and a granular fluorescence seen with rotavirus antibody was probably non-specific.197880631
phosphatase activity of aerobic and facultative anaerobic bacteria.1115 strains of aerobic and facultatively anaerobic bacteria were tested for phosphatase activity by a conventional plate method and a microtest. the microtest was devised to allow results to be read after 4 h cultivation. phosphatase activity was found in wide range of species and strains. besides staphylococci, where the test for phosphatase is successfully used, it may be applied as one of the valuable tests for the differentiation of the following species: bacillus cereus, b. licheniformis, ...1978216188
pseudomonas maltophilia: identification of the hydrocarbons, glycerides, and glycolipoproteins of cellular lipids.the nature of quantity of the free lipids of pseudomonas maltophilia have been examined. lipid components identified as phosphatidyl ethanolamine, phosphatidyl glycerol, diphosphatidyl glycerol, phosphatidylamino acid derivatives and phosphatidic acid accounted for about one-half of the total lipids and are generally typical of gram-negative bacteria. the remaining lipids were identified as a complex family of aliphatic hydrocarbon isomers (c22--c32) and a mixture of glycolipoproteins. these com ...1978657006
[phosphohydrolase activity of pseudomonas maltophilia].the activity of phosphohydrolase (acid, alkaline, pyrophosphatase) was studied in two strains of pseudomonas maltophilia: vcm-b-591 and sse-b-715. the activity of these enzyme systems in these strains was found to be much higher than in other pseudomonas species, viz. ps. aeruginosa vcm-b-889, ps. fluorescens vcm-b-553, ps. geniculata sse-b-338, and in e. coli b. the phosphohydrolase activity of ps. maltophilia varied depending on the growth phase of the culture. the highest activity of acid pho ...1979231188
production of an extracellular ribonuclease by pseudomonas maltophilia.as part of a screening program for pseudomonad enzymes having an industrial interest, we selected ribonuclease (rnase) producing strains. of the 150 pseudomonads screened, 6 were found to produce an extracellular rnase activity when grown on solid medium. in broth culture, the rnase activity from these six species remained bound to the cells unless gelatin was added to the medium. gelatin was essential for the release of rnase in the broth culture, but the ph of the medium, addition of potential ...197936976
gentamicin resistance in christchurch hospitals.prior to june 1976, the isolation of gentamicin resistant organisms was an infrequent occurrence in north canterbury hospital board institutions. during july 1976, 20 different gentamicin resistant organisms were isolated from patients in christchurch hospital. gentamicin resistant organisms hav e been continually isolated from an increasingly wide area since then. the organisms involved are: providence species; pseudomonas aeruginosa; klebsiella species; e coli; staphyloccus aureus; proteus mir ...1979381994
nonfermentative bacilli: evaluation of three systems for identification.three systems for the identification of nonfermentative bacilli were evaluated for their rapidity and accuracy of identification of 217 strains. two of the systems, api 20e (api) and oxi/ferm tube (oxif), are available as kits; the oxidative attack (oa) system is not commerically available. the overall accuracies of the oa, api, and oxif systems were 91, 69, and 50%, respectively. identification within 48 h was achieved for 98% of the strains by oa, for 50% by api, and for 18% by oxif. most of t ...1979389945
the sensitivity of gentamicin-resistant gram-negative bacilli to cefotaxime, other cephalosporins and aminoglycosides.the sensitivities of 80 gentamicin-resistant gram-negative bacilli to cefotaxime, cefuroxime, cefoxitin, cefamandole, cefazolin, tobramycin, netilmicin and amikacin were determined. amikacin was the most active amino-glycoside. however, the percentage sensitivity to cefotaxime of most of the species was higher than, or equal to any of the other antibiotics tested. cefotaxime was particulary active against providencia spp., serratia spp., klebsiella spp., and pseudomonas maltophilia, being 16 to ...1979478651
susceptibility of pseudomonas maltophilia to antimicrobial agents, singly and in combination.pseudomonas maltophilia is resistant to most of the commonly used antimicrobial agents including those active against pseudomonas aeruginosa. the susceptibility of 14 clinical isolates of p. maltophilia to 18 antimicrobial agents was determined by broth dilution testing. all organisms were susceptible to trimethoprim-sulfamethoxazole (tmp-smz), minocycline, and ly127935. a total of 87 and 79% of the organisms were susceptible in vitro to colistin and chloramphenicol, respectively. with the excep ...1979533264
distribution in clinical material and identification of pseudomonas maltophilia.during the 10-year period ending march 1976, 128 (8.5%) of 1506 strains of gram-negative non-fermentative bacteria submitted to the national collection of type cultures for computer-assisted identification have been strains of pseudomonas maltophilia. these figures suggest that ps. maltophilia is both a relatively common species in clinical material in the united kingdom and also that many laboratories experience difficulty in identifying this species. we report the sources from which our strain ...1979429581
primary pseudomonas maltophilia infection of the lung.to our knowledge, this is the first reported case of primary pseudomonas maltophilia pneumonia. presenting symptoms were fever and chills of two days' duration and a density in the right upper lobe. sputum culture showed normal flora, and multiple blood cultures were negative. antibiotic therapy initially with penicillin and then with carbenicillin was unsuccessful. selective bronchial aspiration yielded pure cultures of p maltophilia. when an appropriate antibiotic, chloramphenicol, was given, ...1979419020
lipopolysaccharides from pseudomonas maltophilia: structural studies of the side-chain polysaccharide from strain n.c.t.c. 10257.a lipopolysaccharide has been isolated from pseudomonas maltophilia n.c.t.c. 10257. monosaccharide components identified were l-rhamnose, 3-o-methyl-l-xylose, l-xylose, d-glucose, d-mannose, d-galacturonic acid, 2-amino-2-deoxy-galactose, 2-amino-2-deoxyglucose, and a 3-deoxy-2-octulosonic acid. heptose was absent. in this and other respects, the lipopolysaccharide resembles the corresponding products from xanthomonas species. mild hydrolysis of the lipopolysaccharide with acid, followed by chro ...1979427832
physiological responses of bacteria to cytochalasin a: effects on growth, transport, and enzyme induction.cytochalasin a at 5 to 25 microgram/ml (1.0 x 10(-5) to 5.2 x 10(-5) m) inhibited the growth of three gram-positive bacteria, arthrobacter sialophilus, staphyloccus aureus, and bacillus amyloliquifaciens, but had little or no effect on the growth of three gram-negative bacteria, excherichia coli, pseudomonas maltophilia, and aeromonas proteolytica. a. sialophilus and s. aureus recovered spontaneously from cytochalasin a-mediated growth inhibition after a considerable lag period, which was depend ...1979422516
antimicrobial susceptibility of acinetobacter calcoaceticus, serratia marcescens, pseudomonas fluorescens and pseudomonas maltophilia to three novel cephalosporin-like antibiotics. 19806777362
evaluation of the minitek system for identification of nonfermentative and nonenteric fermentative gram-negative bacteria.the minitek identification system (mt) was compared with a conventional testing battery for the characterization of 735 isolates which included 57 species and groups of nonfermentative (nf) and nonenteric fermentative (nef) gram-negative bacteria. the mt correctly identified 585 of 616 nf (94,96%) and 115 of 119 nef (96.65%) bacteria and 700 of 735 strains (95.24%) overall. a total of 31 nf and nef (4.22%) bacteria were misidentified, and no identification was determined for four strains (0.69%) ...19806999019
evaluation of the four-hour micro-id technique for direct identification of oxidase-negative, gram-negative rods from blood cultures.a 4-h micro-id technique for direct identification of oxidase-negative gram-negative rods from positive blood cultures was compared to subculture and species identification of single colonies by api 20e and micro-id, using standardized inocula. a total of 127 patients (220 positive cultures) were studied. isolates included 96 escherichia coli, 46 klebsiella pneumoniae, 7 klebsiella oxytoca, 8 enterobacter aerogenes, 17 enterobacter cloacae, 19 serratia marcescens, 2 serratia liquefaciens, 8 prot ...19806999020
moxalactam (ly127935), a new semisynthetic 1-oxa-beta-lactam antibiotic with remarkable antimicrobial activity: in vitro comparison with cefamandole and tobramycin.moxalactam (ly127935) exhibited greater in vitro activity than cefamandole and tobramycin against clinical isolates of enterobacteriaceae, aeromonas hydrophila, and pseudomonas maltophilia. the activities of the three drugs against other microorganisms were as follows: for staphylococci, cefamandole = tobramycin greater than moxalactam; for streptococci, cefamandole greater than moxalactam greater than tobramycin; and for pseudomonas aeruginosa, tobramycin greater than moxalactam greater than ce ...19806446880
headspace analysis of volatile metabolites of pseudomonas aeruginosa and related species by gas chromatography-mass spectrometry.gas chromatographic-mass spectrometric analysis of headspace volatiles was performed on cultures of 11 strains of pseudomonas aeruginosa and 1 strain each of pseudomonas cepacia, pseudomonas putida, pseudomonas putrefaciens, pseudomonas fluorescens, and pseudomonas maltophilia. all strains of pseudomonas aeruginosa produced a distinctive series of odd-carbon methyl ketones, particularly 2-nonanone and 2-undecanone, and 2-aminoacetophenone. the other strains failed to produce 2-aminoacetophenone. ...19806775012
antibacterial activities of a new stabilized thienamycin, n-formimidoyl thienamycin, in comparison with other antibiotics.the in vitro activity of a new crystalline derivative of thienamycin, n-formimidoyl thienamycin (mk0787), was tested against 46 laboratory reference strains and 2,158 clinical isolates of gram-positive and -negative bacteria, including anaerobes, and compared with cefoxitin, cefaxolin, carbenicillin, and amikacin. mk0787 was significantly more active than the reference antibiotics against most bacteria tests. mk0787 was 16- to 500-fold more active than the other antibiotics against staphylococcu ...19806931548
digestion of algin by pseudomonas maltophilia and pseudomonas putida.pseudomonas maltophilia and pseudomonas putida were identified as alginolytic species. two media used for demonstrating alginolytic activity are described. the applied aspects of the ability of these two species to digest algin are discussed.19807356324
[presence of pseudomonas maltophilia in the rhizosphere of several cultivated plants].pseudomonas maltophilia has been identified in the rhizosphere of several cultured plants: cabbage, rape, mustard, corn, beet. in comparison with nonrhizospheric soil, all the rhizospheric samples analysed contain more of this pseudomonas and the most important stimulation is supplied by cruciferous plants. the possible relation with greater amounts of sulphur-containing amino acids in root secretion is suggested.19807378940
relationship of primer specificity of fatty acid de novo synthetase to fatty acid composition in 10 species of bacteria and yeasts.fatty acid compositions of lipids from six bacteria and four yeasts were determined. fatty acid de novo synthetases were investigated with respect to chain length specificity towards acyl-coa primers of various chain lengths. four species of bacteria (bacillus subtilis, corynebacterium cyclohexanicum, micrococcus luteus, and pseudomonas maltophilia) possess branched-chain fatty acids of the iso and anteiso series as the major acids. de novo synthetases from these organisms exhibited specificity ...19807459715
synergistic interaction in vitro with use of three antibiotics simultaneously against pseudomonas maltophilia.an abbreviated three-dimensional checkerboard titration method was devised to determine whether synergistic interaction of three antimicrobial agents could be found against multidrug-resistant bacteria. pseudomonas maltophilia was used as the test organism because of its resistance to most commercially available antimicrobial agents, including those active against pseudomonas aeruginosa. three-dimensional isobolograms with concave surfaces were formed when synergy occurred. triple combinations o ...19807441019
nosocomial bacteremia. an epidemiologic overview.each year nosocomial bacteremia develops in approximately 194,000 patients in u.s. hospitals (5/1,000); 75,000 die. these infections portend $.28 to $.86 billion added costs to health care. most nosocomial bacteremias occur endemically and are secondary bacteremias, caused by postoperative wound or intra-abdominal infections, urinary tract infections or pneumonia; primary bacteremias most frequently originate from intravascular devices, but the source is unrecognized. between 1965 and 1978, 97 e ...19817211906
pseudomonas maltophilia bacteremia in children undergoing open heart surgery.pseudomonas maltophilia was isolated from intraoperative blood cultures in eight of 13 children undergoing open heart surgery during a five-week period. antibiograms were identical and included resistance to prophylactic antibiotics. the source of the outbreak was traced to contamination of both the calibration device used on the pressure monitoring system and the sensor surface of transducers used in this system. in a mock system, calibration with a contaminated device resulted in recovery of t ...19817277630
[relationship of pseudomonas maltophilia alkaline phosphatase to its membranes].the localization of alkaline phosphomonoesterase (ec 3.1.3.1) was studied in two pseudomonas species: p. maltophilia vkm b-591 and p. aeruginosa vkm b-889. the former species is characterized by constitutive synthesis of alkaline phosphatase, and its level is not regulated by orthophosphate in the medium. the enzyme of the latter species is orthophosphate-repressible. the two species differ also in the localization of the enzyme in the cell. under the conditions of derepression (the absence of i ...19816796809
piperacillin in surgical infections: a clinical trial.piperacillin was administered in eighteen patients with mixed infections. three had osteomyelitis, two had peritonitis, two had gangrenous toes, one had bronchopneumonia, and the other ten had leg ulcers of various types accompanies by cellulitis. in eleven patients one of the infecting organisms was pseudomonas aeruginosa, and another had pseudomonas maltophilia. all had appropriate surgical treatment, which in nine patients included skin grafting in the presence of pseudomonas aeruginosa. all ...19816460496
[exogenous orthophosphate regulation of the phosphohydrolase activities of pseudomonas aeruginosa and pseudomonas maltophilia].the activity of several phosphohydrolases, viz. alkaline phosphatase (ec 3.1.3.1), acid phosphatase (ec 3.1.3.2), atpase (ec 3.6.1.3), tripolyphosphatase (ec 3.6.1.2) and polyphosphatase (ec 3.6.1.11), was studied in pseudomonas aeruginosa vkm b-889 and pseudomonas maltophilia vkm b-591. in the absence of orthophosphate in the medium when alkaline phosphatase was derepressed, its activity in p. aeruginosa rose in parallel with that of acid phosphatase, tripolyphosphatase and polyphosphatase. the ...19816276704
lymphocyte transformation to specific antigens associated with crohn's disease.specific lymphocyte transformation to three micro-organisms that have been implicated in crohn's disease was performed. these were pseudomonas maltophilia, mycobacterium kansasii and rotavirus. no significant differences were observed for any of the antigens tested. simultaneous testing of nonspecific stimulation by pha also showed no difference between patients and controls. these results do not support an aetiological role for these organisms mediated by a purely cellular mechanism.19816284623
in vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of beta-lactams, aminoglycosides, and trimethoprim.norfloxacin is a quinolinecarboxylic acid compound. we examined the in vitro activity of this compound against gram-positive and -negative species, including anaerobic species. it inhibited 90% (mic90) of strains of escherichia coli at 0.05 microgram/ml, klebsiella sp. at 0.4 microgram/ml, salmonella and shigella spp. at 0.1 microgram/ml, citrobacter sp. at 0.4 microgram/ml, enterobacter cloacae at 0.2 microgram/ml, enterobacter aerogenes at 0.4 microgram/ml, and enterobacter agglomerans at 0.2 ...19826214995
in vitro activity of azthreonam, a monobactam antibiotic.we studied the activity of azthreonam (sq 26,776), a novel monocyclic beta-lactam compound, against a variety of clinical isolates. it was more potent than moxalactam, cefoperazone, cefamandole, cefoxitin, ticarcillin, tobramycin, or amikacin against strains of klebsiella spp., serratia spp., and the proteus group. it was highly effective against escherichia coli and strains of salmonella spp. the median minimal inhibitory concentration for all species of enterobacteriaceae was less than or equa ...19826891198
nonfermenting gram-negative bacteria and their differentiation from pseudomonas aeruginosa.pseudomonas aeruginosa strains and other nonfermenting gram-negative bacteria isolated from surgical patients and environmental washings at a surgical in-patient department were characterized bacteriologically. the biochemical and cultivation features of 156 p. aeruginosa strains, 35 strains of oxidase-negative and 31 strains of oxidase-positive gram-negative bacteria other than p. aeruginosa were studied. nonpigmented p. aeruginosa strains and strains with delayed pigmentation accounted for, re ...19827161487
sensitivity of 341 non-fermentative gram-negative bacteria to seven beta-lactam antibiotics.susceptibility of 341 isolates of non-fermentative gram-negative bacteria to carbenicillin, piperacillin, cefoperazone, moxalactam, cefotaxime, ceftizoxime, and n-formimidoyl thienamycin was determined by the agar dilution and disc diffusion methods. piperacillin was the most active agent against pseudomonas aeruginosa, thienamycin the most active against pseudomonas fluorescens and pseudomonas putida, and moxalactam the most active against pseudomonas maltophilia. piperacillin and thienamycin w ...19827173181
csf infections complicating the management of neoplastic meningitis. clinical features and results of therapy.this study analyzes the clinical and bacteriologic features of csf infections that occurred in patients with neoplastic meningitis treated with thiotepa and methotrexate administered through a subcutaneous reservoir and ventricular catheter (srvc). thirty-one patients were treated, and csf infections occurred in four (13%). staphylococcus epidermidis was the infecting organism in each case and pseudomonas maltophilia occurred with s epidermidis in one patient. fever, headache, lethargy, and evid ...19826802096
reliability of early identifications obtained with enterobacteriaceae-plus biochemical cards in the automicrobic system.the automicrobic system (ams) is capable of identifying most enterobacteriaceae within 8 h and many glucose-nonfermenting, gram-negative bacilli after 13 h of incubation. early preliminary results can be readily obtained from the computer as the tests incubate. data with 1,023 bacterial isolates were reviewed to determine the relative accuracy of 4-, 6-, 8-, 10-, and 13-h identifications. all automicrobic system identifications with probability (p) values of less than 0.80 were considered equivo ...19826749890
in vitro comparison of cefotetan with five other cephalosporins against nosocomial pathogens.the in vitro activity of cefotetan against staphylococcus aureus and gram-negative bacterial strains including nonfermenting species has been compared with that of cefoxitin, cefotaxim, moxalactam, cefoperazone and ceftazidime by use of an agar dilution method. cefotetan was found to be inactive against pseudomonas aeruginosa and acinetobacter species and only moderately active against staphylococcus aureus, pseudomonas maltophilia, pseudomonas cepacia, and enterobacter cloacae. it was more acti ...19826958416
studies on glucose nonfermentative gram-negative bacilli. iii. plasmid-mediated antibiotic resistance in pseudomonas maltophilia. 19826958815
in vitro and in vivo activity of dl-8280, a new oxazine derivative.dl-8280, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7h- pyrido-(1,2,3-de)1,4-benzoxazine-6-carboxylic acid, is a new nalidixic acid analog with a broad spectrum of antibacterial activity against gram-negative and gram-positive bacteria, including obligate anaerobes. the activity of dl-8280 against enterobacteriaceae, pseudomonas aeruginosa, haemophilus influenzae, neisseria gonorrhoeae, and clostridium perfringens was roughly comparable to that of norfloxacin and far exceede ...19826960805
purification and properties of inducible penicillin beta-lactamase isolated from pseudomonas maltophilia.two types of beta-lactamase were found in the cell-free extract from pseudomonas maltophilia gn12873. one was an inducible penicillin beta-lactamase, and the other was an inducible cephalosporin beta-lactamase. the purified penicillin beta-lactamase gave a single protein band on polyacrylamide gel electrophoresis. the isoelectric point was 6.9, and the approximate molecular weight was 118,000 by gel filtration and 26,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, suggesting th ...19826983856
[micavibrio admirandus gen. et sp. nov].micavibrio gen. nov. (m.l. fem. n. mica--a tiny thing and m.l. masc. n. vibroia generic name, m.l. masc. n. micavibrio a tiny vibrio). cells are single, small curved rods, in motile stage with a single polar not sheathed flagellum. reproduced by binary division, gram-negative. cells attach to host-bacteria cells and grow as exoparasites destroying the host, may exhibit a host-range specificity. the g + c content of the dna of the strain examined is 57,1% m. isolated from sewage waters. the type ...19827070304
enzymatic profile of pseudomonas maltophilia.an enzymatic profile of 20 strains of pseudomonas maltophilia was undertaken with conventional plate tests, api zym, and 4-methylumbelliferyl-conjugated substrates. all strains produced dnase, rnase, arbutinase, esterases and lipases, mucinase, acid and alkaline phosphatases, alkaline pyrophosphate diesterase, phosphoamidase, beta-glucosidase, leucine arylamidase, and acetatase and were hemolytic for horse, sheep, and rabbit blood. the majority of strains produced chitinase, hyaluronidase, album ...19826813350
[susceptibilities of pseudomonas species to aminoglycosides and tetracyclines].pseudomonas aeruginosa has attracted much attention through its role in hospital outbreaks of disease. however, other members of the genus pseudomonas, particularly pseudomonas maltophilia and pseudomonas cepacia, may be isolated as opportunistic pathogens of man, and can be found in hospital materials. these organisms have been less susceptible to the commonly used antibiotics. this report deals with the in vitro sensitivity of pseudomonas strains except for p. aeruginosa to aminoglycosides and ...19827131756
infections caused by pseudomonas maltophilia with emphasis on bacteremia: case reports and a review of the literature.ten cases of pseudomonas maltophilia bacteremia were identified over a five-year period at the university of pittsburgh medical center. our experience and a review of the literature show that p. maltophilia can cause a wide spectrum of disease. we present cases of pneumonia and infections of the biliary tract and urinary tract in which the organism was isolated simultaneously from blood. p. maltophilia endocarditis occurs in the context of iv drug abuse or as a postoperative complication of pros ...19827156659
lipopolysaccharides from pseudomonas maltophilia. structural studies of the side-chain, core, and lipid-a regions of the lipopolysaccharide from strain nctc 10257.structural studies have been carried out on the o-specific polysaccharide, the core oligosaccharide, and the lipid a from the lipopolysaccharide of pseudomonas maltophilia nctc 10257. by means of 13c nuclear magnetic resonance spectroscopy, a tetrasaccharide repeating-unit for the o-specific polymer has been confirmed. however, the data suggest that the l-rhamnopyranosyl residue at the branching point has the alpha configuration rather than beta as proposed previously [neal, d.j. and wilkinson, ...19827173201
isolation of pseudomonas maltophilia from human stools with thienamycin.p. maltophilia, a thienamycin-resistant species, was isolated by means of thienamycin-blood agar (10 mg/l) from 14 out of 218 stools. macconkey agar with thienamycin was inhibitory for part of the strains.19836675350
activities of aztreonam and new cephalosporins against infrequently isolated gram-negative bacilli.the susceptibilities of 159 clinical isolates of glucose nonfermentative gram-negative bacilli were determined for eight new monobactam or beta-lactam antibiotics. imipemide (n-formimidoyl thienamycin) was effective against the largest number of species, although not against pseudomonas maltophilia. cefoperazone and ceftazidime, but not cefsulodin, were active against infrequently isolated pseudomonas species. aztreonam, moxalactam, cefotaxime, and ceftizoxime demonstrated selective activity aga ...19836685453
in-vitro and in-vivo antibacterial activity of imipenem against clinical isolates of bacteria.imipenem, a derivative of thienamycin, a carbapenem antibiotic, has a broad spectrum of activity against aerobic (gram-positive and gram-negative) and anaerobic bacteria. it is quite stable to all tested beta-lactamases produced by various species of bacteria isolated from clinical specimens, whether plasmid or chromosomally mediated. one exception is its hydrolysis by the beta-lactamase produced by pseudomonas maltophilia which is thus usually resistant to imipenem. imipenem was found to be hyd ...19836607914
synergy with double and triple antibiotic combinations compared.combinations of two sets of antibiotics (gentamicin-carbenicillin-rifampicin and trimethoprim/sulphamethoxazole-carbenicillin-rifampicin) were tested against isolates of pseudomonas maltophilia. an abbreviated checker-board method permitted tests with combinations of all three antibiotics and of each of the possible three pairs in each set. triple combinations were usually synergistic, whereas 25% of combinations of pairs were antagonistic or additive. the modal degree of synergy was greater wit ...19836662835
comparative in vitro activity of norfloxacin against urinary tract pathogens.the in vitro activity of norfloxacin (mk366) against 477 aerobic gram-negative and gram-positive clinical isolates was compared to that of nalidixic acid, nitrofurantoin, ampicillin, cephalexin, trimethoprim, sulfamethoxazole, and the combination trimethoprim-sulfamethoxazole. norfloxacin was more active than the other agents against all gram-negative organisms tested. minimal inhibitory concentrations (mics) of pseudomonas aeruginosa were less than or equal to 0.125-32 mg/l with 90% inhibited ( ...19836224679
60co-irradiation as an alternate method for sterilization of penicillin g, neomycin, novobiocin, and dihydrostreptomycin.the effects of the use of 60co-irradiation to sterilize antibiotics were evaluated. the antibiotic powders were only occasionally contaminated with microorganisms. the d-values of the products and environmental isolates were 0.028, 0.027, 0.015, 0.046, 0.15, 0.018, and 0.19 mrads for aspergillus species (uc 7297, 7298), a. fumigatus (uc 7299), rhodotorula species (uc 7300), penicillium oxalicum (uc 7269), pseudomonas maltophilia (uc 6855), and a biological indicator microorganism, bacillus pumil ...19836186803
direct dilution sampling, quantitation, and microbial assessment of open-system ventilation circuits in intensive care units.in a systematic approach, 37 duplicate samples of open system circuits (bennett ma-1 ventilators) of patients in medical and surgical intensive care units were processed by direct and serial (apha guidelines) dilutions. the paired difference test on 15 of the in-use circuitry solution samples indicated no difference between the direct and serial dilution methods (p less than 0.001). seventy-seven additional respiratory therapy circuitry samples from similar intensive care patients were analyzed ...19836575015
lipopolysaccharides from pseudomonas maltophilia: composition of the lipopolysaccharide and structure of the side-chain polysaccharide from strain n.c.i.b. 9204.lipopolysaccharide was extracted from defatted cell-walls of pseudomonas maltophilia n.c.i.b. 9204. the major fatty acid components were 9-methyldecanoic acid, 2-hydroxy-9-methyldecanoic acid, 3-hydroxy-9-methyldecanoic acid, 3-hydroxy-dodecanoic acid, and 3-hydroxy-11-methyldodecanoic acid. monosaccharide components of the phosphorylated core-oligosaccharide were d-glucose, d-mannose, d-galacturonic acid, 2-amino-2-deoxyglucose, and a 3-deoxyoctulosonic acid. the putative o-specific polysacchar ...19836831490
dna hybridization studies of the association of pseudomonas maltophilia with inflammatory bowel diseases.an infectious etiology has been suggested for the inflammatory bowel diseases, crohn's disease and ulcerative colitis, and an association of cell wall-defective variants of pseudomonas maltophilia and pseudomonas-like group va bacteria with crohn's disease has been reported by parent and mitchell. seven of the parent-mitchell isolates were compared by using dna hybridization and six were identical and similar, but not identical, to a type strain of p. maltophilia. the seventh isolate showed exte ...19836854128
micromethod for carbon substrate assimilation by pseudomonas maltophilia.assimilation of 60 carbon sources by 114 pseudomonas maltophilia strains, identified by conventional methods, was studied by a standardized micromethod (api strip). automatic reading of growth intensity was done at 1, 2 and 4 days. growth kinetics of reference strain nctc 10257 were also studied and showed evidence of different growth according to the substrates. the results agreed well with nutritional patterns reported. this micro-method seems suitable for daily use by laboratories because of ...19836362276
in vitro antibacterial activity of sm-1652, a new broad-spectrum cephalosporin with antipseudomonal activity.sm-1652 (sodium 7-[d(-)-alpha-(4-hydroxy-6-methylpyridine-3-carboxamido)-alpha-(4-hydroxyphenyl)acetamido]-3-[(1-methyl-1h-tetrazol-5-yl) thiomethyl]-3-cephem-4-carboxylate) is a new semisynthetic cephalosporin derivative with a broad spectrum of antibacterial activity. its in vitro activity against gram-positive bacteria was comparable to that of cefazolin. sm-1652 exceeded cefazolin in potency and broadness of antibacterial activity against such enterobacteriaceae as indole-positive proteus sp ...19836601470
susceptibility of 324 nonfermentative gram-negative rods to 6 cephalosporins and azthreonam.susceptibility of 324 isolates of nonfermentative gram-negative bacteria to cephalothin, cefamandole, cefoxitin, ceftazidime, cefsulodin, and azthreonam was determined by agar dilution and disc diffusion techniques. with the exception of moraxella species, first- and second-generation cephalosporins were minimally active against nonfermenters tested. cefsulodin and azthreonam were mainly active against pseudomonas aeruginosa. in contrast, ceftazidime and ceftriaxone exhibited wider activity spec ...19836311492
comparative in vitro activities of third-generation cephalosporins.the in vitro susceptibilities of 823 clinical isolates to eight third-generation cephalosporin and cephalosporinlike antibiotics were studied. all eight antibiotics were more active and had broader spectrums of activity against gram-negative bacilli and anaerobes than older derivatives; however, they were less active against gram-positive cocci. cefotaxime sodium, cefmenoxime hydrochloride, ceftriaxone disodium, and ceftizoxime sodium had similar activities. cefoperazone sodium was more active t ...19836615095
serratia ficaria isolated from a leg ulcer.serratia ficaria was isolated from culture of a leg ulcer of a 44-year-old woman who had venous insufficiency and alcoholic cirrhosis. although pseudomonas maltophilia, p acidovorans, and enterobacter cloacae were also present, s ficaria was isolated in large numbers and was considered to contribute significantly to this infection. this represents the third known clinical isolation of this bacterium.19836648629
pseudomonas maltophilia endocarditis. 19846534862
susceptibility of gram-negative bacteria to polymyxin b nonapeptide.subinhibitory concentrations of polymyxin b nonapeptide sensitized all 21 polymyxin-susceptible gram-negative bacterial strains studied to hydrophobic antibiotics such as fusidic acid, novobiocin, and erythromycin. the susceptibility increases were usually 30- to 300-fold. the strains included representatives of escherichia coli with different o- and k-antigens, klebsiella pneumoniae, klebsiella oxytoca, enterobacter cloacae, enterobacter agglomerans, salmonella typhimurium, acinetobacter calcoa ...19846331296
collaborative evaluation of the abbott avantage system for identification of frequently isolated nonfermentative or oxidase-positive gram-negative bacilli.the capability of the abbott avantage system to identify 10 species of commonly isolated glucose nonfermentative or oxidase-positive gram-negative bacilli in a 5-h test period was evaluated in a collaborative study. the avantage nonenteric data base uses 20 biochemical test reactions performed in an expanded abbott bacterial identification cartridge plus the results of a manual oxidase test. the species included in the avantage data base are acinetobacter anitratus, acinetobacter iwoffi, aeromon ...19846392323
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