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isolation and characterization of novel human parechovirus from clinical samples.using vero cells, we isolated a virus (nii561-2000) from a cerebrospinal fluid specimen of a 1-year-old girl with reye syndrome. the determined amino acid sequence of the virus indicated that the isolate was a human parechovirus (hpev), a member of picornaviridae. neutralization test showed that the nii561-2000 virus had distinct antigenicity to hpev-1, hpev-2, and hpev-3, and that the sequence was distinct from these types as well as from hpev-4 and hpev-5. thus, we propose the virus (nii561-20 ...200717553229
severe neonatal parechovirus infection and similarity with enterovirus infection.enteroviruses (ev) are an important cause of neonatal disease including hepatitis, meningoencephalitis, and myocarditis that can lead to death or severe long-term sequelae. less is known about severe neonatal infection caused by the parechoviruses (pev) of which type 1 (pev1) and type 2 (pev2) were previously known as echovirus 22 and echovirus 23. they belong to the same family of picornaviridae as the ev. of the pev, so far only pev3 has been associated in 2 recent reports with severe neonatal ...200818277927
isolation and identification of a novel human parechovirus.a cytopathic agent (a308/99) was isolated using vero cells from a stool specimen of a 1-year-old patient with transient paralysis. the agent was approximately 28 nm in diameter with a distinct ultrastructure resembling the virus particle of an enterovirus. it could not be neutralized by antisera against human picornaviruses such as human enterovirus, aichi virus or human parechovirus. the virion contained three capsid proteins with molecular masses of 38, 30.3 and 30 kda. determination of the co ...200414769896
parechoviruses, a novel group of human picornaviruses.parechoviruses are a recently established group of human viral pathogens. at the time of their first isolation, parechoviruses were classified among the enterovirus genus in the picornavirus family, but based on their different biological properties they were separated into their own genus. the type member is human parechovirus 1 (hpev1), which frequently infects humans, in particular small children. the parechovirus genus also includes hpev2 and the ljungan virus, which was recently isolated fr ...200111680794
human parechovirus 1 infections in young children--no association with type 1 diabetes.the epidemiology, transmission and clinical symptoms of human parechoviruses [hpev, classified earlier as enteroviruses; echovirus 22 (hpev1) and echovirus 23 (hpev2)] remain poorly characterized. enteroviruses and one parechovirus species, the ljungan virus, have been associated with type 1 diabetes in humans and rodents. the occurrence of human parechovirus 1 (hpev1) infections in young children and their possible association with type 1 diabetes was evaluated. the prospective birth cohort stu ...200717311340
molecular analysis of human parechovirus type 2 (formerly echovirus 23).picornaviruses have been divided into five genera until recently, when a sixth genus, parechovirus, was defined. human parechovirus type 1 (hpev1; formerly echovirus 22) was the first recognized member of this genus and preliminary sequence analysis of echovirus 23 [now renamed human parechovirus type 2 (hpev2)] suggested that it is also a parechovirus. here we describe the complete nucleotide and predicted amino acid sequences of hpev2, which indicate a close relationship to hpev1 throughout th ...19989820139
complete sequence of echovirus 23 and its relationship to echovirus 22 and other human enteroviruses.to define the relationship between echovirus 23 (e23) and other human enteroviruses, we have determined the complete nucleotide sequence of a strain of e23 isolated from a child with high fever in connecticut in 1986 and compared the nucleotide and deduced amino acid sequences with those of other enteroviruses representing each of the major enterovirus phylogenetic groups, poliovirus type 1, coxsackievirus a16, coxsackievirus b3, echovirus 22 (e22), and enterovirus 70. the genome of e23 (strain ...19989783471
detection of all known parechoviruses by real-time pcr.the parechovirus genus of the picornaviridae family contains two species, human parechovirus (hpev) and ljungan virus (lv). the hpevs (including the former echoviruses 22 and 23, now hpev type 1 (hpev1) and hpev2, respectively) cause a wide spectrum of disease, including aseptic meningitis, gastroenteritis, encephalitis, acute respiratory illness, and neonatal sepsis-like disease. the lvs were isolated from bank voles in sweden during a search for an infectious agent linked to fatal myocarditis ...200818524969
longitudinal observation of parechovirus in stool samples from norwegian infants.parechoviruses are assumed to be common infectious agents, but their epidemiologic and pathogenic properties are not well known. the aim of the present study was to assess the prevalence and molecular epidemiology of parechovirus in norwegian infants, as well as to investigate whether the presence of virus correlated with symptoms of infection. a group of 102 infants was longitudinally followed: 51 infants with a high genetic risk for type 1 diabetes (aged 3-35 months), and 51 children without t ...200818712841
electron microscopic study of the morphogenesis of echovirus 23. 1975803900
removal of enteroviruses from sewage by bench-scale rotary-tube trickling filters.the efficacy of a rotary-tube type of trickling filter for removing coxsackievirus a9, poliovirus 1, and echovirus 12 suspended in raw settled sewage was investigated. at filtration rates equivalent to about 10 mgd (million gallons per day)/acre (ca. 3,785 m3/day per acre), the filters removed 95% of the poliovirus, 83% of echovirus 12, and 94% of coxsackievirus a9. coliform, fecal streptococci, biochemical oxygen demand, and chemical oxygen demand removals were remarkably similar, averaging 94, ...1975169731
cell-surface interactions of echovirus 22.echovirus 22 (ev22) is a picornavirus forming a distinct molecular cluster together with echovirus 23. ev22 has an arg-gly-asp (rgd) peptide motif in its capsid protein vp1; similar motifs are known to mediate many cell-cell and microbe-host interactions. to identify peptide sequences that specifically bind to ev22 and potentially play a role in receptor recognition, we have used here peptide libraries displayed in filamentous phage. we isolated an ev22-binding motif clrsg(r/f)gc. the synthetic ...19979261123
human parechoviruses--biology and clinical significance.a new genus of the family picornaviridae, parechovirus, has recently been recognised on the basis of distinctive biological and molecular properties. in particular: parechoviruses exhibit characteristic effects on the host cell; cleavage of the capsid protein vp0, required for maturation of the virus particle in most other picornaviruses, does not occur; there is a unique extension, which is highly basic in character, to the n-terminus of the capsid protein vp3; and the 2a protein, in common wit ...200010654005
[spread of echovirus 23 in a neonatal pathology unit]. 19827171245
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