| [a case of cat scratch disease in a patient with diabetes mellitus and chronic renal failure]. | the article describes a case of cat scratch disease in a female patient with severe chronic pathology. this relatively rare disease was manifested by regional (in the site of microbial intrusion) lymphadenopathy, and general infectious syndrome. the presence of oncohematological process was excluded without biopsy; serologic examination with bartonella antibodies confirmed the diagnosis. combined treatment with two antibiotics, rifampicin and doxycycline, was successful. the article stresses tha ... | 2006 | 16924805 |
| autocrine role for interleukin-8 in bartonella henselae-induced angiogenesis. | the gram-negative bacterium bartonella henselae is capable of causing angiogenic lesions as a result of infection. previously, it has been shown that b. henselae infection can result in production of the chemokine interleukin-8 (il-8). in this study, we demonstrated that monocytes, endothelial cells, and hepatocytes produce il-8 in response to b. henselae infection. we also investigated the role of il-8 in b. henselae-induced endothelial cell proliferation and capillary tube formation. both in v ... | 2006 | 16926411 |
| systemic cat scratch disease. | systemic cat scratch disease (csd) is often associated with prolonged fever and microabscesses in the liver and/or spleen. we report a case of systemic csd with hepatic, splenic and renal involvement in an aboriginal child in taiwan. a previously healthy 9-year-old girl had an intermittent fever for about 17 days, and complained of abdominal pain, headache and weight loss. abdominal computed tomography showed multiple tiny hypodense nodular lesions in the spleen and both kidneys. laparotomy reve ... | 2006 | 16935770 |
| genome rearrangements, deletions, and amplifications in the natural population of bartonella henselae. | cats are the natural host for bartonella henselae, an opportunistic human pathogen and the agent of cat scratch disease. here, we have analyzed the natural variation in gene content and genome structure of 38 bartonella henselae strains isolated from cats and humans by comparative genome hybridizations to microarrays and probe hybridizations to pulsed-field gel electrophoresis (pfge) blots. the variation in gene content was modest and confined to the prophage and the genomic islands, whereas the ... | 2006 | 16936024 |
| molecular characterization of resistance to macrolides in bartonella henselae. | we selected in vitro erythromycin-resistant strains of bartonella henselae. the mutants obtained had point mutations in domain v of 23s rrna and/or in ribosomal protein l4. one lymph node of a patient with cat-scratch disease had such a mutation in 23s rrna, suggesting that natural resistant strains may infect humans. | 2006 | 16940128 |
| case records of the massachusetts general hospital. case 27-2006. a 17-year-old boy with fever and lesions in the liver and spleen. | | 2006 | 16943407 |
| analysis of data in 30 patients with cat scratch disease without lymphadenopathy. | the prominent clinical manifestation of cat scratch disease is regional lymphadenopathy at the site of the cat scratch or bite, associated with fever or general symptoms. a serological study of 540 patients with either lymphadenopathy, persistent fever, or pet ownership disclosed that 30 (16.1%) of the 186 patients with a serological diagnosis of cat scratch disease had no regional lymphadenopathy, and in these 30 patients, the absence of lymphadenopathy was closely related to the presence of pe ... | 2006 | 16944264 |
| prevalence of dna of mycoplasma haemofelis, 'candidatus mycoplasma haemominutum,' anaplasma phagocytophilum, and species of bartonella, neorickettsia, and ehrlichia in cats used as blood donors in the united states. | to identify the prevalence of dna of mycoplasma haemofelis; 'candidatus mycoplasma haemominutum'; anaplasma phagocytophilum; and species of bartonella, neorickettsia, and ehrlichia in blood of cats used as blood donors in the united states. | 2006 | 16948578 |
| prevalence of bartonella henselae antibodies in serum of cats with and without clinical signs of central nervous system disease. | bartonella henselae is occasionally associated with neurological dysfunction in people and some experimentally infected cats. the purpose of this study was to determine whether b henselae seroprevalence or titer magnitude varies among cats with neurological disease, cats with non-neurological diseases, and healthy cats while controlling for age and flea exposure. there was no difference in b henselae seroprevalence rates between cats with seizures and cats with other neurological diseases. cats ... | 2006 | 16949848 |
| [a case of hepatosplenic cat scratch disease]. | a 43-year-old man was admitted with idiopathic fever. abdominal ultrasonogram demonstrated multiple hypoechoic lesions in the spleen. abdominal ct scan showed multiple hypodense lesions in the liver and spleen. the patient had a cat in his house, and the presence of a very high serous antibody titer for bartonella henselae led to the diagnosis of hepatosplenic cat scratch disease. it is important to consider this disease in the differential diagnosis of idiopathic fever when multiple lesions are ... | 2006 | 16953102 |
| [hepatosplenic localization of cat scratch disease: two cases in immunocompetent adult patients]. | cat-scratch disease (csd) is a well-recognized benign cause of localized lymphadenopathy, which often recovers spontaneously. however systemic clinical presentations are described in immunodeficient adults (bacillary angiomatosis, bacillary splenitis) and are less common in immunocompetent ones. | 2006 | 16959382 |
| somatostatin receptor scintigraphy in patients with cat-scratch disease. | somatostatin receptor scintigraphy images various neoplastic, granulomatous, and auto-immune diseases. cat-scratch disease in an infectious granulomatous disease usually affecting the lymphnodes. it is not known whether cat-scratch disease provides positive somatostatin receptor scintigrams. | 2006 | 16964341 |
| [cat scratch disease--course, diagnosis]. | cat scratch disease is an infection which often causes regional lymphadenopathy. bartenolloses present a growing health problem both in human and veterinary medicine. they may be etiological fevers of unknown etiology, endocarditis, pneumonia, meningitis. the mildest clinical form is the cat scratch disease which proceeds as a mild regional lymphadenopathy. it is caused by bartonellosis henselae. animals, especially cats, are the sourse of infections. lymphadenitis may remain for many weeks and ... | 2006 | 16964683 |
| characterization of th1 activation by bartonella henselae stimulation in balb/c mice: inhibitory activities of interleukin-10 for the production of interferon-gamma in spleen cells. | this study was conducted to analyze cytokine production mechanisms in mice after bartonella henselae stimulation. balb/c mice were inoculated intraperitoneally with 3 x 10(6) colony forming units of b. henselae (houston-1 strain) twice at 10-day interval. spleen cells were harvested from the mice and stimulated with the organisms. following the stimulation, interferon-gamma (ifn-gamma) and interleukin-4 (il-4), il-10, il-12 and tumor necrosis factor-alpha (tnf-alpha) were measured in the culture ... | 2007 | 17005337 |
| isolated hepatic involvement of cat scratch disease in immunocompetent adults: enhanced magnetic resonance imaging, pathological findings, and molecular analysis--two cases. | visceral involvement in absence of lymphadenopathy is a rare manifestation in cat scratch disease; hepatic granulomas are rare, representing 0.3% of systemic manifestations of cat scratch disease, and gallbladder extension is a singular case. the present article refers to 2 rare cases of visceral cat scratch disease in immunocompetent adults with hepatic granulomatous inflammation, caused by bartonella henselae infection, with gallbladder involvement in 1 case and no lymphadenopathy. histologica ... | 2006 | 17041206 |
| analysis of bartonella adhesin a expression reveals differences between various b. henselae strains. | bartonella henselae causes cat scratch disease and the vasculoproliferative disorders bacillary angiomatosis and peliosis hepatis in humans. one of the best known pathogenicity factors of b. henselae is bartonella adhesin a (bada), which is modularly constructed, consisting of head, neck/stalk, and membrane anchor domains. bada is important for the adhesion of b. henselae to extracellular-matrix proteins and endothelial cells (ecs). in this study, we analyzed different b. henselae strains for ba ... | 2007 | 17060468 |
| lymph node biopsy specimens and diagnosis of cat-scratch disease. | we report microbiologic analysis of 786 lymph node biopsy specimens from patients with suspected cat-scratch disease (csd). the specimens were examined by standard, cell culture, and molecular methods. infectious agents were found in samples from 391 (49.7%) of 786 patients. the most commonly identified infectious agent was bartonella henselae (245 patients, 31.2%), the agent of csd. mycobacteriosis was diagnosed in 54 patients (6.9%) by culture and retrospectively confirmed by using a specific ... | 2006 | 17073081 |
| indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following listeria monocytogenes infection. | control of pathogens by formation of abscesses and granulomas is a major strategy of the innate immune system, especially when effector mechanisms of adaptive immunity are insufficient. we show in human listeriosis that dcs expressing indoleamine 2,3-dioxygenase (ido), together with macrophages, are major cellular components of suppurative granulomas in vivo. induction of ido by dcs is a cell-autonomous response to listeria monocytogenes infection and was also observed in other granulomatous inf ... | 2006 | 17111046 |
| bartonella henselae endocarditis in a child. | 14-year-old white male with a past medical history of congenital bicuspid aortic valve, streptococcus viridans endocarditis, and pulmonary valve homograft presented with culture-negative endocarditis. molecular studies identified the causative organism as bartonella henselae and subsequent serologic studies supported this diagnosis. this rare cause of endocarditis may be under recognized in children. bartonella henselae endocarditis should be considered in all children with culture-negative endo ... | 2006 | 17111290 |
| infective endocarditis due to bartonella spp. and coxiella burnetii: experience at a cardiology hospital in sao paulo, brazil. | bartonella spp. and coxiella burnetii are recognized as causative agents of blood culture-negative endocarditis (bcne) in humans and there are no studies of their occurrences in brazil. the purpose of this study is to investigate bartonella spp. and c. burnetii as a causative agent of culture-negative endocarditis patients at a cardiology hospital in são paulo, brazil. from january 2004 to december 2004 patients with a diagnosis of endocarditis at our institute were identified and recorded prosp ... | 2006 | 17114712 |
| arthropod-borne diseases in homeless. | homeless people are particularly exposed to ectoparasite. the living conditions and the crowded shelters provide ideal conditions for the spread of lice, fleas, ticks, and mites. body lice have long been recognized as human parasites and although typically prevalent in rural communities in upland areas of countries close to the equator, it is now increasingly encountered in developed countries especially in homeless people or inner city economically deprived population. fleas are widespread but ... | 2006 | 17114713 |
| prevalence of rickettsia felis-like and bartonella spp. in ctenocephalides felis and ctenocephalides canis from la rioja (northern spain). | our aim was to determine the presence of rickettsia spp. and bartonella spp. in ctenocephalides felis and ctenocephalides canis from la rioja (spain). a total of 88 specimens were tested by polymerase chain reaction (pcr) using glta and ompb genes as targets for rickettsia spp., and 16s rrna and ribc genes for bartonella spp. rickettsia felis-like (28.4%), bartonella clarridgeiae (6.8%), and bartonella henselae (3.4%) were detected in ctenocephalides spp. other bartonella sp. different from b. c ... | 2006 | 17114721 |
| a translocated bacterial protein protects vascular endothelial cells from apoptosis. | the modulation of host cell apoptosis by bacterial pathogens is of critical importance for the outcome of the infection process. the capacity of bartonella henselae and b. quintana to cause vascular tumor formation in immunocompromised patients is linked to the inhibition of vascular endothelial cell (ec) apoptosis. here, we show that translocation of bepa, a type iv secretion (t4s) substrate, is necessary and sufficient to inhibit ec apoptosis. ectopic expression in ecs allowed mapping of the a ... | 2006 | 17121462 |
| [endocarditis due to bartonella spp. three new clinical cases and spanish literature review]. | | 2006 | 17125688 |
| [prevalence of bartonella henselae antibodies in chilean children, adolescents and veterinary workers]. | bartonella henselae is the causative agent of cat-scratch disease. | 2006 | 17130969 |
| transient paresis associated with cat-scratch disease: case report and literature review of vertebral osteomyelitis caused by bartonella henselae. | cat-scratch disease (csd) rarely presents as vertebral osteomyelitis. we describe a case with paresis of the arm with total recovery after antibiotic and neurosurgical therapy. we reviewed 20 other cases of csd vertebral osteomyelitis in the literature. this diagnosis should be considered in patients with systemic symptoms, back pain, and cat contact. the prognosis is generally good. | 2006 | 17133166 |
| an unusual outcome in a child with hepatosplenic cat-scratch disease. | typical cat-scratch disease (bartonella henselae infection) in an immunocompetent child is usually associated with a history of scratch, bite or intimate contact with a cat. most patients develop a non-tender papule in the scratch line after three to ten days. this may persist for only a few days or as long as two to three weeks. during the next two weeks or more, regional lymph nodes that drain the area gradually enlarge and then slowly resolve in more than 10% of patients. the nodes develop ov ... | 2006 | 17136337 |
| bone infection in cat-scratch disease: a review of the literature. | to describe the main features of bone infection associated with cat-scratch disease (csd). | 2007 | 17140668 |
| [bartonella henselae as a cause of optical nerve neuritis]. | bartonella henselae is included into the group of gram-negative bacteria that can cause not so rare disease known as cat-scratch disease (csd). this disease is characterized by the specific general symptoms, and the complications in the eyes can be manifested in the form of neuroretinitis, follicular conjunctivitis and focal chorioretinitis. in this paper clinical and epidemiological characteristics of a patient with ophthalmologic complications caused by bartonella henselae are described. we in ... | 2006 | 17144434 |
| effect of high-dose methyl-prednisolone on brainstem encephalopathy and basal ganglia impairment complicating cat scratch disease. | cat scratch disease (csd) is a zoonotic illness caused by the gram negative bacillus bartonella henselae characterized by a small skin lesion at the site of a bite, lick or scratch by a cat, commonly followed by regional lymphadenopathy 1 or 2 weeks later. we report herein on severe neurological complications of csd combining brainstem encephalopathy and basal ganglia impairment. this 12-year-old female acutely presented to a local hospital with profound coma and a prolonged tonic posturing of e ... | 2007 | 17174500 |
| an unusual cutaneous presentation of cat-scratch disease. | | 2007 | 17176268 |
| [cat-scratch disease. review of eight adult patients hospitalized for fever or adenopathy]. | cat-scratch disease is common among children. among adults the disease is less often considered in the differential diagnosis of enlarged lymph nodes and fever. | 2006 | 17186093 |
| pyogenic splenic abscess in an infant with serological evidence of cat scratch disease. | | 2007 | 17186270 |
| [serous macular detachment as an atypical sign in cat scratch disease]. | case report: a 58-year-old woman presented with 0.1 visual acuity in the left eye associated with a serous retinal detachment of the macula as the only ocular manifestation of cat scratch disease. this diagnosis was made by serum antibody titers and the clinical course. discussion: although uncommon, cat scratch disease should be considered in patients with a serous detachment in the macula region of the retina. | 2006 | 17199167 |
| the low seroprevalence of tick-transmitted agents of disease in dogs from southern ontario and quebec. | infectious diseases caused by pathogens transmitted by ticks and other insect vectors are an important cause of morbidity and mortality in both dogs and humans throughout north america. the purpose of this study was to determine the seroprevalence of selected vector-transmitted pathogens in southern ontario and quebec. samples submitted to the vector borne disease diagnostic laboratory (vbddl) at the north carolina state university college of veterinary medicine were evaluated for antibodies to ... | 2006 | 17217089 |
| [rash and purulent lymphadenitis in cat scratch disease]. | we present a case of a cat-scratch disease (csd) presenting with typical (primary lesion and regional lymphadenitis) and rare (purulent lymphadenitis and maculopapular rash) symptoms and positive epidemiological data. laboratory blood test showed normal values for routine parameters, except for mild leukocytosis (l 12.4 x 10(9)), elevated erythrocyte sedimentation rate (se 65/h) and moderately elevated asparta e-aminotransferase and alanine-aminotransferase values (ast/alt 48/90), fibrinogen (5. ... | 2006 | 17217106 |
| cat-scratch disease relapse in a kidney transplant recipient. | cat-scratch disease, an infectious illness infrequently reported in kidney transplant patients, is caused by the organism bartonella henselae and is transmitted through contact with cats or kittens. it is a self-limited disorder in the general pediatric population. here we present a case of unsuspected cat-scratch disease in a pediatric kidney transplant patient who presented with fever and lymphadenopathy. eight months after treatment with a short course of azithromycin, the patient developed a ... | 2007 | 17239132 |
| cat scratch disease causing hepatic masses after liver transplant. | hepatic cat scratch disease is rarely reported in liver transplant recipients and has never been reported with discrete liver lesions in the graft. a 52-year-old woman was transplanted for hepatitis c cirrhosis and hepatocellular carcinoma. her posttransplant course was uneventful. she presented 2.7 years after transplantation with fever of unknown origin and went on to develop multiple and diffuse discrete liver lesions. despite an extensive work-up including percutaneous and laparoscopic biops ... | 2007 | 17241393 |
| bartonella infections in fleas (siphonaptera: pulicidae) and lack of bartonellae in ticks (acari: ixodidae) from hungary. | fleas (95 pulex irritans, 50 ctenocephalides felis, 45 ctenocephalides canis) and ixodid ticks (223 ixodes ricinus, 231 dermacentor reticulatus, 204 haemaphysalis concinna) were collected in hungary and tested, in assays based on pcr, for bartonella infection. low percentages of p. irritans (4.2%) and c. felis (4.0%) were found to be infected. the groel sequences of the four isolates from p. irritans were different from all the homologous sequences for bartonellae previously stored in genbank bu ... | 2006 | 17252927 |
| bartonella henselae infection in splenectomized domestic cats previously infected with hemotropic mycoplasma species. | cat scratch disease is caused by bartonella henselae and the domestic cat represents its main reservoir. in immunocompromised patients, infection with b. henselae is characterized by more severe clinical forms than in non-immunocompromised individuals. the objective of the present study was to investigate the characteristics of b. henselae (houston-i strain) infection in four splenectomized and three non-splenectomized cats, five of which were chronically infected with 'candidatus mycoplasma hae ... | 2007 | 17254639 |
| detection of rickettsia rickettsii and bartonella henselae in rhipicephalus sanguineus ticks from california. | sixty-two questing adult rhipicephalus sanguineus (latreille) ticks were collected by direct removal from blades of turfgrass and adjacent concrete walkways at a suburban home in riverside county, ca, and tested for the presence of rickettsia, bartonella, and ehrlichia dna. polymerase chain reaction (pcr) was used to amplify fragments of the 17-kda antigen gene and the rompa gene of the spotted fever group rickettsiae. one male tick contained r. rickettsii dna; its genotype differed from r. rick ... | 2007 | 17294935 |
| an hiv-positive patient with cervical lymphadenopathy and skin lesions. | | 2007 | 17304465 |
| adult systemic cat scratch disease associated with therapy for hepatitis c. | we describe the first case of systemic cat scratch disease in a patient receiving peginterferon alpha-2a and ribavirin for treatment of hepatitis c. cases of adult systemic csd are extremely infrequent and immunomodulatory treatment for hepatitis c has been associated with aberrant host responses to common pathogens. | 2007 | 17319959 |
| experimental infection of domestic cats with passaged genotype i bartonella henselae. | the influence of in vitro passage on bartonella henselae pathogenesis in cats has not been thoroughly evaluated. our objective was to examine the bacterial kinetics and humoral immune responses in cats experimentally infected with three different in vitro passages of b. henselae f1, a genotype i strain of feline origin. the f1 strain was in vitro passaged 20 and 40 times, and each was inoculated into a group of 5 cats. the kinetics of bacteremia and the feline humoral immune response to bacteria ... | 2007 | 17321078 |
| detection of bartonella henselae dna in two dogs with pyogranulomatous lymphadenitis. | 1 dog evaluated because of inappetence and lameness of the left hind limb of 1 day's duration and 1 dog evaluated because of inappetence, fever, and lymphadenopathy of 2 weeks' duration. | 2007 | 17331050 |
| recurrent expressive aphasia as a presentation of cat-scratch encephalopathy. | cat-scratch disease is a common disease, occurring in an estimated 24,000 patients annually in the united states, and is one of the most common causes of chronic lymphadenitis in children. a wide array of neurologic complications occurs as a result of cat-scratch disease. however, there have been no reports of acute-onset, self-resolving, recurrent, expressive aphasia, as we report here in an adolescent boy. in our case, establishing the diagnosis of cat-scratch encephalopathy saved time and res ... | 2007 | 17332191 |
| cat scratch disease during etanercept therapy. | lymphadenopathy in a patient taking tnfalpha antagonist therapy may indicate lymph node tuberculosis or a hematological malignancy. although histological evidence of granuloma suggests tuberculosis, many other infections responsible for granulomatous reactions have been reported in patients on tnfalpha antagonist therapy. we report a case of granulomatous lymphadenopathy due to bartonella henselae in a patient taking etanercept to treat ankylosing spondylitis. | 2007 | 17337229 |
| cat scratch disease with epidural extension while on antimicrobial treatment. | we report the first case of a child with an epidural abscess caused by bartonella henselae. this case is unique in that the diagnosis was confirmed by polymerase chain reaction (pcr) of the abscess fluid. a 3-year-old male was admitted with a 1-week history of fever and lower back pain. magnetic resonance imaging (mri) of the lumbar spine revealed a paraspinal soft tissue abnormality extending from the t(12) to the l(4) level, and a computed tomography (ct) scan of the lumbar spine showed osteom ... | 2007 | 17337934 |
| bartonella henselae lymphadenitis progressing to hepatosplenic disease with slow clinical response despite early diagnosis and treatment. | | 2008 | 17343673 |
| a combined approach for the enhanced detection and isolation of bartonella species in dog blood samples: pre-enrichment liquid culture followed by pcr and subculture onto agar plates. | historically, direct plating, lysis centrifugation, or freeze-thaw approaches have proven to be highly insensitive methods for confirming bartonella species infection in dogs. a prospective study was designed to compare diagnostic methods for the detection of bartonella using samples submitted to the vector-borne disease diagnostic laboratory at north carolina state university. methods included indirect immunofluorescence assay, pcr, direct inoculation of a blood agar plate (trypticase soy agar ... | 2007 | 17346836 |
| encephalitis lethargica following bartonella henselae infection. | | 2007 | 17351727 |
| seropositivity rates for bartonella henselae, toxocara canis and toxoplasma gondii in new zealand blood donors. | bartonella henselae, toxocara canis and toxoplasma gondii organisms can all cause vision-threatening posterior segment disease. diagnosis relies heavily on clinical findings, but detection of antibodies in the patient's serum may be helpful in some cases. the significance of a positive serology result depends on the seroprevalence in the general population. seroprevalence rates for these organisms vary widely around the world and this study aimed to determine the rates for a new zealand populati ... | 2007 | 17362453 |
| serological testing for bartonella henselae infections in the netherlands: clinical evaluation of immunofluorescence assay and elisa. | cat-scratch disease (csd), caused by bartonella henselae infection, can mimic malignancy and can manifest atypically. reliable serological testing is therefore of great clinical importance. the diagnostic performance of immunofluorescence assay (ifa) and elisa was evaluated in a group of dutch patients with proven csd (clinical diagnosis confirmed by pcr). sera of 51 csd patients and 56 controls (patients with similar symptoms, but who were b. henselae pcr-negative and had an alternative confirm ... | 2007 | 17378931 |
| development of discriminatory multiple-locus variable number tandem repeat analysis for bartonella henselae. | bartonella henselae is a zoonotic bacterium that infects cats and humans. several attempts have been made to develop typing techniques for epidemiological purposes; however, most of the techniques developed do not appear to be sufficiently discriminatory or easy to use. in order to develop multilocus variable number tandem repeat (vntr) analysis (mlva) for b. henselae, 30 vntr candidates were selected from the genome sequence of the reference strain houston 1 (h1). the vntr candidates were initi ... | 2007 | 17379723 |
| evaluation of pulsed-field gel electrophoresis and multi-locus sequence typing for the analysis of clonal relatedness among bartonella henselae isolates. | pulsed-field gel electrophoresis (pfge) represents the gold standard among band-based methods for the molecular typing of bartonella henselae. smai and noti have been frequently used for typing b. henselae by pfge. however, their appropriateness for the analysis of genetic relatedness among b. henselae isolates has not been assessed systematically hitherto. aim of the present study was to evaluate smai, noti, and three additional endonucleases for typing b. henselae isolates by pfge and to compa ... | 2007 | 17398157 |
| chronic vasculitis and polyneuropathy due to infection with bartonella henselae. | bartonella henselae, the causative agent of cat scratch disease and bacillary angiomatosis, is associated with an expanding spectrum of diseases. here, we report on a 40-year-old patient suffering from chronic recurrent painful ulcers of the toes, distal axonal sensomotor polyneuropathy and raynaud's phenomenon. biopsy of the sural nerve demonstrated an axonal neuropathy with a neurogenic muscular atrophy. treatment with high dose corticosteroids had no beneficial effect. a biopsy taken from a r ... | 2007 | 17401716 |
| presence of bartonella spp. in various human populations. | bartonella spp. bacteria are significant human pathogens and the agents of bacterial zoonosis acquired from an animal companion. the aim of the study was to determine the seroprevalence of two of the most common bartonella species b. henselae and b. quintana in various human populations. the studied groups included: alcoholics, intravenous drug users, veterinarians, cats' owners. blood samples were collected and cultured on chocolate agar plates and in mouse fibroblasts l-929 cell line culture. ... | 2007 | 17419187 |
| bartonellosis: suggestive case reports in adult and pediatric patients and therapeutic issues. | cat-scratch disease warrants extensive investigation, from an epidemiological, a diagnostic, but especially a therapeutic point of view. two suggestive episodes of bartonella henselae-caused cat-scratch disease are reported, and discussed in the light of the most recent literature evidence. the first case occurred in a 60-year-old man, thus suggesting that it is important to maintain an elevated level of suspicion for this disease in adults as well. both episodes were characterized by a very pro ... | 2006 | 17420917 |
| [atypical cat scratch disease in an immunocompetent school-aged child]. | | 2007 | 17430722 |
| from cat scratch disease to endocarditis, the possible natural history of bartonella henselae infection. | most patients with infectious endocarditis (ie) due to bartonella henselae have a history of exposure to cats and pre-existing heart valve lesions. to date, none of the reported patients have had a history of typical cat scratch disease (csd) which is also a manifestation of infection with b. henselae. | 2007 | 17442105 |
| [painful soft-tissue swelling of the upper arm]. | cat-scratch disease is an infection by bartonella henselea and resolves spontaneously. we present a case of untypical bartonella infection which was misinterpreted by mri as a soft-tissue sarcoma of the upper arm. the histological findings of an incision biopsy were unspecific, without signs of malignancy. the tumor was excised completely and the final histology, however, showed no evidence of malignant changes. the bartonella henselae infection could be confirmed by polymerase chain reaction. t ... | 2008 | 17443304 |
| [generalized lymphadenitis associated with hashimoto's thyroiditis]. | a 26-year-old pakistani woman was admitted to hospital with fever, nausea and vomiting, abdominal pain and general weakness for the previous two weeks, but no diarrhea or constipation. antibiotic therapy as an out-patient had not provided relief. she also had enlarged cervical lymph nodes. she reported that she had always been in good health before onset of the described symptoms. | 2007 | 17443443 |
| [pediatric pneumonia, pleural effusion, and pericarditis following cat scratch disease and serological cross-reactions among bartonella henselae and rickettsia japonica determined by indirect fluorescence antibodies]. | cat scratch disease is associated with a variety of systemic manifestations. we report a pediatric case associated with pneumonia, pleural effusion, and pericarditis. a 3-year-old boy developed prolonged fever unresponsive to antibiotic treatment, including azithromycin and minocycline. although the fever resolved with corticosteroid treatment, bartonella henselae igg titer was positive in indirect fluorescence antibodies, as was rickettsia japonica igg titer. both titers were significantly redu ... | 2007 | 17447481 |
| bartonella henselae infection presenting as a unilateral acute maculopathy. | the purpose of this article is to report an unusual ocular manifestation of cat scratch disease (csd) presenting as a unilateral acute maculopathy (uam). we describe and review the clinical, laboratory, fluorescein angiography (fa), indocyanine green angiography (icg) and optical coherence tomography (oct) records of a patient with csd. | 2007 | 17458800 |
| detection of opportunistic infections by low-density microarrays: a diagnostic approach for granulomatous lymphadenitis. | in molecular diagnosis of infectious diseases often more than 1 pathogen has to be considered. as a consequence, a series of labor-intensive and time-consuming polymerase chain reaction (pcr) approaches specific for different putative pathogens have to be carried out. to speed up diagnosis, we established a low-density microarray for simultaneous detection of diverse putative pathogens causing a disease such as granulomatous lymphadenitis. nucleic acids from formalin-fixed, paraffin-embedded tis ... | 2007 | 17471154 |
| idiopathic facial aseptic granuloma: a multicentre prospective study of 30 cases. | idiopathic facial aseptic granuloma (ifag) was recently described in a single-centre retrospective study as a skin condition that occurs specifically in childhood. | 2007 | 17493068 |
| cat scratch disease from a domestic dog. | cat scratch disease (csd), caused by bartonella henselae, is a zoonosis and characterized by self-limited lymphadenopathy. it is transmitted commonly by scratch or bite from cats or kitten. we report an unusual case of csd caused by a domestic dog scratch that we believe is the first report in taiwan. a 23-year-old healthy woman developed cervical lymphadenopathy, mild fever, headache, and malaise 3 days after dog scratch. her symptoms improved after azithromycin treatment. serology proved b. he ... | 2007 | 17493900 |
| unusual concurrent detection by polymerase chain reaction of bartonella henselae and parvovirus b19 in an immunocompetent child with erythema nodosum and hepatic granulomatous disease. | we report an unusual case of documented bartonella henselae genotype i from hepatic tissue in an italian immunocompetent girl presenting with erythema nodosum and hepatic granulomata. polymerase chain reaction (pcr) was performed on biopsied liver sample to confirm the etiologic role of b. henselae and to identify the genetic variant of this organism. a pcr on the same liver biopsy for parvovirus b19 was also positive, but the clinical meaning of this was not clear. | 2007 | 17532594 |
| prolonged follow up of seven patients affected by hepatosplenic granulomata due to cat-scratch disease. | this study is a retrospective analysis of seven patients with hypoechogenic lesions in the liver and/or spleen due to bartonella henselae, who were followed from 1998 through to 2005 by the department of pediatrics, turin university. in addition to showing constitutional symptoms, four children had skin lesions suggestive of injuries inflicted by cats, and one child had a history of exposure to cats. the origin of the infection remained undefined in the other two patients. humoral tests enabled ... | 2008 | 17541640 |
| two cases of endocarditis due to bartonella henselae. | | 2007 | 17546106 |
| bartonella species in blood of immunocompetent persons with animal and arthropod contact. | using pcr in conjunction with pre-enrichment culture, we detected bartonella henselae and b. vinsonii subspecies berkhoffii in the blood of 14 immunocompetent persons who had frequent animal contact and arthropod exposure. | 2007 | 17553243 |
| discovery of new infectious diseases - bartonella species. | | 2007 | 17554115 |
| [bartonella infection in hematological practice]. | to characterize the clinical and histological features of bartonella infection in patients asking for hematological advice and to assess the significance of serological and molecular methods for the diagnosis of this infection. | 2007 | 17564022 |
| images in emergency medicine. bartonella henselae lymphadenitis. | | 2007 | 17572294 |
| canine bartonellosis: serological and molecular prevalence in brazil and evidence of co-infection with bartonella henselae and bartonella vinsonii subsp. berkhoffii. | the purpose of this study was to determine the serological and molecular prevalence of bartonella spp. infection in a sick dog population from brazil. at the são paulo state university veterinary teaching hospital in botucatu, 198 consecutive dogs with clinicopathological abnormalities consistent with tick-borne infections were sampled. antibodies to bartonella henselae and bartonella vinsonii subsp. berkhoffii were detected in 2.0% (4/197) and 1.5% (3/197) of the dogs, respectively. using 16s-2 ... | 2007 | 17583666 |
| utility of mr imaging in cat-scratch neuroretinitis. | about 80% of cat-scratch disease (csd) infections occur in children, and csd neuroretinitis (optic neuropathy with retinal exudates in a "macular star" pattern) mostly occurs in children and young adults. a recent study suggested that csd optic neuropathy has specific features on mr imaging. however, mr imaging findings in csd neuroretinitis are not well described in the pediatric literature. we present a patient with csd neuroretinitis in whom these specific mr imaging features preceded the mac ... | 2007 | 17583805 |
| bartonella henselae exists as a mosaic of different genetic variants in the infected host. | bartonella henselae is a fastidious bacterium associated with infections in humans and cats. the mechanisms involved in the long-term survival of bartonellae despite vigorous host immune responses are poorly understood. generation of genetic variants is a possible strategy to circumvent the host specific immune responses. the authors have recently demonstrated the coexistence of different genetic variants within the progeny of three primary b. henselae isolates from berlin by pfge analysis. aims ... | 2007 | 17600049 |
| bartonella henselae in ixodes ricinus ticks removed from dogs. | bartonella spp. is an etiologic agent of vector-borne infections. bartonella spp. was searched for in adult ixodes ricinus ticks removed from dogs and cats using specific polymerase chain reaction (pcr) and sequence analysis of glta gene. bartonella henselae dna was detected in 5 of 102 tested ticks. all pcr-positive ticks were removed from dogs. four of were engorged, one was unfed. the data demonstrate that b. henselae is able to inhabit ticks. this is the first report about the existence of b ... | 2007 | 17627437 |
| vaccines for emerging infections. | emerging infectious diseases represent a grave threat to animal and human populations in terms of their impact on global health, agriculture and the economy. vaccines developed for emerging infections in animals can protect animal health and prevent transmission of zoonotic diseases to humans. examples in this paper illustrate how industry and public health can collaborate to develop a vaccine to prevent an emerging disease in horses (west nile virus vaccine), how poultry vaccination can protect ... | 2007 | 17633303 |
| role of magnetic resonance imaging and scintigraphy in the diagnosis and follow-up of osteomyelitis in cat-scratch disease. | cat-scratch disease (csd) is a self-limiting infectious disease characterised with lymphadenopathy in a patient with a history of cat contact. cases of bone involvement in patients with csd are rare. we reported a case of 11-year-old boy with prolonged intermittent fever, inguinal lymphadenopathy and osteomyelitis. he had a history of exposure to kittens. the physical examination revealed a febrile boy without an apparent site of infection except an enlarged inguinal lymph node. its histopatholo ... | 2007 | 17635689 |
| transverse myelitis in 2 patients with bartonella henselae infection (cat scratch disease). | cat scratch disease is usually a benign, self-limiting condition. neurological manifestations are uncommon and may consist of encephalopathy, seizures, and coma. this report describes 2 cases of transverse myelitis: 1 case in a 46-year-old man who had lymph node biopsy and serological testing results that were positive for bartonella henselae and 1 case in a 13-year-old adolescent boy who had serological testing results that were positive for b. henselae. these are 2 of the only 3 cases of trans ... | 2007 | 17638185 |
| [development of a quantitative real-time polymerase chain reaction for detecting bartonella henselae]. | to develop a quantitative real-time polymerase chain reaction (pcr) for detecting bartonella henselae. | 2007 | 17649663 |
| familial occurrence of cat-scratch disease, with varying clinical expression. | cat-scratch disease, primarily caused by bartonella henselae, typically presents with regional adenopathy, and the role of antibiotics in the treatment is debatable. we present a report of b. henselae infection transmitted by the same kitten to 4 different individuals, each with different clinical characteristics, treatment, and evolution. | 2007 | 17654352 |
| bartonella-induced endothelial cell proliferation is mediated by release of calcium from intracellular stores. | the facultative intracellular bacterium bartonella henselae induces unique angiogenic lesions in immunocompromised hosts. to determine the role of intracellular calcium pools in b. henselae-induced endothelial cell proliferation, we generated b. henselae-conditioned medium (bcm) and tested the ability of these cell-free proteins to induce human umbilical vein endothelial cell (huvec) proliferation, cxcl8 production, and intracellular ca2+ signals. huvecs incubated with bcm for 3 days had higher ... | 2007 | 17678436 |
| seroprevalence of bartonella henselae in dogs and cats in sassari. | | 2007 | 17682904 |
| [abscessing lymphadenitis in a 1.5-year-old boy]. | at present, bartonella species are increasingly important as infectious agents in both animals and humans. bartonella henselae, the most frequently diagnosed species, is known to cause numerous clinical syndromes in both immunocompetent and immunocompromised patients. in healthy individuals, the infection is most commonly manifested as the so-called cat scratch disease. the manifestations include erythema or papule at the point of entry of infection (site of injury) and regional lymphadenitis. t ... | 2007 | 17703405 |
| prevalence of serum antibodies against bartonella species in the serum of cats with or without uveitis. | bartonella henselae has been implicated as a causative agent of chronic uveitis in people and in some cats. the objective of this study was to determine whether bartonella species seroprevalence or titer magnitude varies among cats with uveitis, cats without ocular diseases recorded and healthy cats, while controlling for age and risk of flea exposure based on state of residence. there was no difference in seroprevalence rates or titer magnitude between cats with uveitis and cats with non-ocular ... | 2008 | 17719256 |
| characterization of an immunogenic outer membrane autotransporter protein, arp, of bartonella henselae. | bartonella henselae is a recently recognized pathogenic bacterium associated with cat scratch disease, bacillary angiomatosis, and bacillary peliosis. this study describes the cloning, sequencing, and characterization of an antigenic autotransporter gene from b. henselae. a cloned 6.0-kb bcli-ecori dna fragment expresses a 120-kda b. henselae protein immunoreactive with 21.2% of sera from patients positive for b. henselae immunoglobulin g antibodies by indirect immunofluorescence, with 97.3% spe ... | 2007 | 17785470 |
| bartonella henselae in the human environment in poland. | the aim of the study was to determine the occurrence of bartonella henselae reservoir and vectors of infection in the close surroundings of human beings in urban areas of central poland. the study included mammals (54 dogs, 137 cats) and 102 adult ixodes ricinus ticks removed from cats and dogs. blood samples were drawn from each animal and cultured on chocolate agar plates and in mouse fibroblasts l-929 cell line culture. the levels of bartonella henselae igg antibodies were determined by indir ... | 2007 | 17852890 |
| discovery and analysis of bartonella henselae antigens for use in clinical serologic assays. | the antibody response to bartonella henselae has been studied in a number of mammals; however, the human response needs to be further studied. after natural infection, humans have antibody reactivity to a large number of b. henselae proteins. we used a proteomic approach to identify antigenic proteins of b. henselae to determine their capacity to elicit a human antibody response. comparing patient sera by western blot analysis demonstrated significant amounts of reactivity to b. henselae. the im ... | 2008 | 17889484 |
| [evaluation of a in house serology reagent for the diagnosis of cat-scratch disease defined by pcr]. | evaluate the sensitivity and the specificity of the cat scratch disease serology by indirect immunofluorescence assay, realized from an in-house antigenic suspension, with pcr defined cases. describe the epidemiological characteristics of the cases. | 2007 | 17905531 |
| cat-scratch disease lymphadenitis. | | 2007 | 17915663 |
| the use of bartonella henselae-specific age dependent igg and igm in diagnostic models to discriminate diseased from non-diseased in cat scratch disease serology. | cat scratch disease (csd) is caused by bartonella henselae infection and is a common cause of regional lymphadenopathy. the diagnosis of csd largely depends on serology, but is hampered by both low sensitivity and specificity of the applied igg and igm assays. using an in-house elisa, we detected a significant age-dependent increase in the igg levels in the general population compared to csd patients. with this knowledge, we developed diagnostic models to differentiate diseased from non-diseased ... | 2007 | 17916395 |
| prevalence of antibodies to bartonella henselae in dogs in italy. | | 2007 | 17921442 |
| a case of fatal disseminated bartonella henselae infection (cat-scratch disease) with encephalitis. | cat-scratch disease resulting from bartonella henselae infection is usually a benign, self-limited process in immunocompetent children. even the rare cases associated with neurologic manifestations are not generally fatal. we report a case of a previously healthy 6-year-old boy with cat-scratch disease, systemic dissemination, and encephalitis that led to his death. autopsy revealed perivascular lymphocytic infiltrates and microglial nodules in the brain. to our knowledge, this finding has not b ... | 2007 | 17922599 |
| bivalvular bartonella henselae prosthetic valve endocarditis. | prosthetic valve endocarditis is an uncommon manifestation of infection with bartonella species. herein, we report a case of bartonella henselae endocarditis involving prosthetic mitral and aortic valves. the patient had a favorable outcome with combined medical and surgical therapy. concomitant crescentic glomerulonephritis led to an initial mistaken diagnosis of wegener's granulomatosis. | 2007 | 17942646 |
| genetic diversity of bartonella henselae in human infection detected with multispacer typing. | we applied multispacer typing (mst) by incorporating 9 variable intergenic spacers to bartonella henselae dna detected in lymph node biopsy specimens from 70 patients with cat-scratch disease (csd), in cardiac valve specimens from 2 patients with endocarditis, and in 3 human isolates from patients with bacillary angiomatosis, csd, and endocarditis. sixteen mst genotypes were found, 5 previously identified in cats and 11 new. of the studied dna, 78.7% belonged to 2 genotypes, which were phylogene ... | 2007 | 17953088 |
| osler's nodes and janeway lesions. | the pathogenesis of osler's nodes and janeway lesions remains a mystery despite vigorous debate over the last 113 years. they are given great emphasis among the clinical signs of bacterial endocarditis but are seldom seen in practice. two cases of subacute bacterial endocarditis are presented. a 66-year-old woman with bartonella henselae endocarditis developed osler's nodes on the hands postoperatively, and a 23-year-old man with streptococcus oralis endocarditis developed tender macules with an ... | 2007 | 17956487 |
| [cat-scratch disease]. | | 2007 | 17969956 |
| multifocal osteomyelitis due to bartonella henselae in a child without focal pain. | we describe a case of an 11-year-old girl who presented with osteomyelitis of the vertebrae and right femur due to bartonella henselae. her only symptom was prolonged fever without focal pain. magnetic resonance imaging (mri) and nested polymerase chain reaction (pcr) were useful for the diagnosis. osteomyelitis due to b. henselae should be considered in cases of prolonged fever of unknown origin. | 2007 | 17982727 |