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dynamics in the concentrations of health-promoting compounds: lupeol, mangiferin and different phenolic acids during postharvest ripening of mango fruit.mango fruit (mangifera indica l.) is renowned for its pleasant taste and as a rich source of health beneficial compounds. the aim of this study was to investigate the changes in concentrations of health-promoting compounds, namely ascorbic acid, carotenoids, antioxidants, lupeol, mangiferin, total phenols and individual phenolic acids, as well as ethylene production and respiration rates during climacteric ripening in 'kensington pride' and 'r2e2' mango fruit.201728786116
the influence of pulsed light exposure mode on quality and bioactive compounds of fresh-cut mangoes.this study investigated the effect of pulsed light (pl) on the respiratory rate, quality (firmness, color and soluble solid content), bioactive compounds (ascorbate and carotenoid) and total antioxidant activity of fresh-cut "tommy atkins" mangoes. fresh-cut mangoes were subjected to pl treatments: control (0p), 1 pulse (1p; 0.7 j cm-2), 4 successive pulses (4p; 2.80 j cm-2) and 1 pulse per day for 4 days (1p4d; 2.80 j cm-2) before storage for 7 days at 6 °c. the 1p and the 4p treatments reduced ...201728740290
physico-chemical changes during progressive ripening of mango (mangifera indica l.) cv. dashehari under different temperature regimes.the effect of different temperature regimes on ripening quality of mango cv. dashehari was investigated. fruits were kept at 20, 25 °c in temperature controlled chambers and at room temperature. fruits were analyzed periodically for physico-chemical characteristics after every 24 h interval up to 168 h of ripening period. development of soluble solid contents (ssc), flesh softening and physiological loss of weight of fruits occurred progressively during ripening. progression of ripening changes ...201728720953
in vitro comparative study of the inhibitory effects of mangiferin and its aglycone norathyriol towards udp-glucuronosyl transferase (ugt) isoforms.mangiferin (mgf), the predominant constituent of extracts of the mango plant mangifera indica l., has been investigated extensively because of its remarkable pharmacological effects. in vitro recombinant ugts-catalyzed glucuronidation of 4-methylumbelliferone (4-mu) was used to investigate the inhibition of mangiferin and aglycone norathyriol towards various isoforms of ugts in our study, which evaluated the inhibitory capacity of mgf and its aglycone norathyriol (ntr) towards udp-glucuronosyltr ...201728621744
regulation and physiological role of silicon in alleviating drought stress of mango.improvement of drought stress of mango plants requires intensive research that focuses on physiological processes. in three successive seasons (2014, 2015and 2016) field experiments with four different strains of mango were subjected to two water regimes. the growth and physiological parameters of possible relevance for drought stress tolerances in mango were investigated. yield and its components were also evaluated. the data showed that all growth and physiological parameters were increased un ...201728603082
consumption of a mango fruit powder protects mice from high-fat induced insulin resistance and hepatic fat accumulation.the aim of this study was to gain more insight into the beneficial effects of mango fruit powder on the early metabolic adverse effects of a high-fat diet.201728578347
synergistic mixtures of chitosan and mentha piperita l. essential oil to inhibit colletotrichum species and anthracnose development in mango cultivar tommy atkins.this study assessed the efficacy of chitosan (chi) and mentha piperita l. essential oil (mpeo) alone or in combination to control the mycelial growth of five different colletotrichum species, c. asianum, c. dianesei, c. fructicola, c. tropicale and c. karstii, identified as potential anthracnose-causing agents in mango (mangifera indica l.). the efficacy of coatings of chi and mpeo mixtures in controlling the development of anthracnose in mango cultivar tommy atkins was evaluated. chi (2.5, 5, 7 ...201728576378
rapid development and validation of improved reversed-phase high-performance liquid chromatography method for the quantification of mangiferin, a polyphenol xanthone glycoside in mangifera indica.mangiferin, a polyphenolic xanthone glycoside from mangifera indica, is used as traditional medicine for the treatment of numerous diseases. the present study was aimed to develop and validate a reversed-phase high-performance liquid chromatography (rp-hplc) method for the quantification of mangiferin from the bark extract of m. indica. rp-hplc analysis was performed by isocratic elution with a low-pressure gradient using 0.1% formic acid: acetonitrile (87:13) as a mobile phase with a flow rate ...201728539748
anti-obesity effects of tea from mangifera indica l. leaves of the ubá variety in high-fat diet-induced obese rats.due to the high content of bioactive compounds, herbal teas are being investigated as adjuvant in chronic disease management. studies have shown that mango leaf tea contain mangiferin, total phenolics and antioxidants, compounds with many functional properties. therefore, this study aims to evaluate the anti-obesity effects of tea from mangifera indica l. leaves, ubá variety (tml), in obese rats fed a high-fat diet (hfd). for this, adult male wistar rats were divided into three groups (n=8): the ...201728514832
mangiferin protects against ‭intestinal ischemia/reperfusion-induced ‭liver injury: ‬‬involvement of ppar-‭γ, gsk-3β and wnt/β-catenin pathway‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬.mangiferin (mf), a xanthonoid from mangifera indica, possesses anti-inflammatory, immunomodulatory, and potent antioxidant effects; however, its protective effect against mesenteric ischemia/reperfusion (i/r)-induced liver injury has not been fully clarified. the study was designed to assess the possible mechanism of action of mf against mesenteric i/r model.201728506911
genetic map of mango: a tool for mango breeding.mango (mangifera indica) is an economically and nutritionally important tropical/subtropical tree fruit crop. most of the current commercial cultivars are selections rather than the products of breeding programs. to improve the efficiency of mango breeding, molecular markers have been used to create a consensus genetic map that identifies all 20 linkage groups in seven mapping populations. polyembryony is an important mango trait, used for clonal propagation of cultivars and rootstocks. in polye ...201728473837
mangiferin: a natural miracle bioactive compound against lifestyle related disorders.the current review article is an attempt to explain the therapeutic potential of mangiferin, a bioactive compound of the mango, against lifestyle-related disorders. mangiferin (2-β-d-glucopyranosyl-1,3,6,7-tetrahydroxy-9h-xanthen-9-one) can be isolated from higher plants as well as the mango fruit and their byproducts (i.e. peel, seed, and kernel). it possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and ...201728464819
transcriptome analysis of mango (mangifera indica l.) fruit epidermal peel to identify putative cuticle-associated genes.mango fruit (mangifera indica l.) are highly perishable and have a limited shelf life, due to postharvest desiccation and senescence, which limits their global distribution. recent studies of tomato fruit suggest that these traits are influenced by the expression of genes that are associated with cuticle metabolism. however, studies of these phenomena in mango fruit are limited by the lack of genome-scale data. in order to gain insight into the mango cuticle biogenesis and identify putative cuti ...201728425468
mangiferin inhibits hippocampal nlrp3 inflammasome and exerts antidepressant effects in a chronic mild stress mice model.a growing body of evidence suggests that inflammation may contribute toward the development of major depressive disorder. mangiferin, a glucosylxanthone from mangifera indica, exerts a number of biological actions, including anti-inflammatory effects. although mangiferin has potential antidepressant activity, the mechanisms of this effect remain unclear. the present study investigated the effects of mangiferin on behavioral changes and inflammatory responses induced by chronic mild stress (cms) ...201728410265
changes in the nutritional quality of five mangifera species harvested at two maturity stages.there are 69 species of edible mangifera recognized in southeast asia. most of these species have not been characterized for nutritional properties. this paper describes the nutritional quality of the pulp of several mangifera species - mangifera casturi, mangifera lalijiwa, mangifera odorata, mangifera zeylanica and two cultivars of mangifera indica, 'tommy-kent' and 'tommy atkins' - at two maturity stages.201728406526
molecular diversity of pakistani mango (mangifera indica l.) varieties based on microsatellite markers.understanding the genetic diversity of different pakistani mango varieties is important for germplasm management and varietal characterization. microsatellites are efficient and highly polymorphic markers for comparative genome mapping, and were used in the present study to determine the genetic relatedness and variability among 15 indigenous mango cultivars (mangifera indica l.). overall, 181 bands were produced using 12 simple sequence repeat (ssr) primers. out of the 12 primers used, 10 were ...201728387877
influence of irrigation during the growth stage on yield and quality in mango (mangifera indica l).although being one of the few drought-tolerant plants, mango trees are irrigated to ensure optimum and consistent productivity in china. in order to better understand the effects of soil water content on mango yield and fruit quality at fruit growth stage, irrigation experiments were investigated and the object was to determine the soil water content criteria at which growth and quality of mango would be optimal based on soil water measured by rhd-js water-saving irrigation system through micro- ...201728384647
exploring and validating physicochemical properties of mangiferin through gastroplus® software.mangiferin (mgf), a promising therapeutic polyphenol, exhibits poor oral bioavailability. hence, apt delivery systems are required to facilitate its gastrointestinal absorption. the requisite details on its physicochemical properties have not yet been well documented in literature. accordingly, in order to have explicit insight into its physicochemical characteristics, the present work was undertaken using gastroplus™ software.201728344830
medicinal plants from northeastern brazil against alzheimer's disease.alzheimer's disease (ad) has been linked with oxidative stress, acetylcholine deficiency in the brain, and inflammatory processes. in the northeast region of brazil, various plants are used to treat several diseases associated with these processes; then an antioxidant test was performed with those plants in a previous work and twelve species with higher antioxidant activity were selected for ache inhibition evaluation. the phenolic compounds content was determined by folin-ciocalteu test and fla ...201728316633
toxic effect of common poisonous plants of district bannu, khyber pakhtunkhwa, pakistan.the present paper was a part of ph.d research work, conducted during the year 2014, in which 87 poisonous plants belonging to 54 genera, were collected, documented and preserved in the herbarium of bannu, department of botany ust, bannu khyber pakhtunkwa pakistan. the plants were identified botanically, arranged alphabetically along with their latin name, family name, common name, poisonous parts, toxicity, affects, toxin and their effects. aim of the study was to induce awareness in the local p ...201829348085
overlap of latent pathogens in the botryosphaeriaceae on a native and agricultural host.some species of the botryosphaeriaceae are capable of infecting a broad range of host plants. we studied the species diversity of botryosphaeriaceae associated with marula (sclerocarya birrea subsp. caffra, anacardiaceae) trees in south africa over two seasons, as well as species common to both s. birrea and adjacent mango (mangifera indica, anacardiaceae) trees in a subset of sites. gene flow amongst populations of botryosphaeriaceae shared on these tree species was tested using microsatellite ...201728317542
surfactant mediated extraction of total phenolic contents (tpc) and antioxidants from fruits juices.the aim of this study was to enhance the extraction of total phenolic contents (tpc) and antioxidants from fruit juices by the application of surfactants formulations instead of conventional solvents (methanol, ethanol and acetone). a variety of fruit infusions: apple red delicious (apple (rd)) (malus domestica), mcintosh apple (apple (i)) (malus pumila), sweet lemon (citrus limetta) and mango (magnifera indica) were studied. effect of water, organic solvents and five different aqueous surfactan ...201525952870
transcriptional sequencing and analysis of major genes involved in the adventitious root formation of mango cotyledon segments.a total of 74,745 unigenes were generated and 1975 degs were identified. candidate genes that may be involved in the adventitious root formation of mango cotyledon segment were revealed. adventitious root formation is a crucial step in plant vegetative propagation, but the molecular mechanism of adventitious root formation remains unclear. adventitious roots formed only at the proximal cut surface (pcs) of mango cotyledon segments, whereas no roots were formed on the opposite, distal cut surface ...201728303391
mangiferin protects against adverse skeletal muscle changes and enhances muscle oxidative capacity in obese rats.obesity-related skeletal muscle changes include muscle atrophy, slow-to-fast fiber-type transformation, and impaired mitochondrial oxidative capacity. these changes relate with increased risk of insulin resistance. mangiferin, the major component of the plant mangifera indica, is a well-known anti-inflammatory, anti-diabetic, and antihyperlipidemic agent. this study tested the hypothesis that mangiferin treatment counteracts obesity-induced fiber atrophy and slow-to-fast fiber transition, and fa ...201728253314
evaluation of cholesterol-lowering activity of standardized extract of mangifera indica in albino wistar rats.cholesterol lowering activity of mangifera indica l. has been determined by earlier researchers and kernel, leaf and bark have shown significant activity. however, the specific cholesterol lowering activity of leaf methanol extract has not been determined.201728250649
mangiferin from pueraria tuberosa reduces inflammation via inactivation of nlrp3 inflammasome.recent reports have demonstrated the role of phyto-constituents in modulating inflammatory responses. mangiferin isolated from mangifera indica is known to induce potent anti-oxidative, anti-diabetic and anti-inflammatory activity. however, the molecular mechanism of its anti-inflammatory activity is not properly understood. in this study we have isolated mangiferin from the tubers of pueraria tuberosa (pt-mangiferin) and analysed the mechanism of its potent anti-inflammatory effects in lps stim ...201728218280
isolation of four phenolic compounds from mangifera indica l. flowers by using normal phase combined with elution extrusion two-step high speed countercurrent chromatography.two-step high speed countercurrent chromatography method, following normal phase and elution-extrusion mode of operation by using selected solvent systems, was introduced for phenolic compounds separation. phenolic compounds including gallic acid, ethyl gallate, ethyl digallate and ellagic acid were separated from the ethanol extract of mango (mangifera indica l.) flowers for the first time. in the first step, gallic acid of 3.7mg and ethyl gallate of 3.9mg with the purities of 98.87% and 99.55% ...201728199916
effects of mangifera indica (careless) on microcirculation and glucose metabolism in healthy volunteers.a commercial mangifera indica fruit powder (careless) showed beneficial acute effects on microcirculation in a randomized, double-blind, crossover pilot study. here, long-term effects on microcirculation and glucose metabolism were investigated in a double-blind, randomized, placebo-controlled, 3-arm parallel-design study in healthy individuals. a daily dose of 100 mg or 300 mg of the fruit powder was compared to placebo after supplementation for 4 weeks. microcirculation and endothelial functio ...201728187466
insights into ligand binding to a glutathione s-transferase from mango: structure, thermodynamics and kinetics.we studied a mango glutathione s-transferase (gst) (mangifera indica) bound to glutathione (gsh) and s-hexyl glutathione (gsx). this gst tau class (migstu) had a molecular mass of 25.5 kda. migstu michaelis-menten kinetic constants were determined for their substrates obtaining a km, vmax and kcat for cdnb of 0.792 mm, 80.58 mm min-1 and 68.49 s-1 respectively and 0.693 mm, 105.32 mm min-1 and 89.57 s-1, for reduced gsh respectively. migstu had a micromolar affinity towards gsh (5.2 μm) or gsx ( ...201728104507
chilling stress upregulates α-linolenic acid-oxidation pathway and induces volatiles of c6 and c9 aldehydes in mango fruit.mango-fruit storage period and shelf life are prolonged by cold storage. however, chilling temperature induces physiological and molecular changes, compromising fruit quality. in our previous transcriptomic study of mango fruit, cold storage at suboptimal temperature (5 °c) activated the α-linolenic acid metabolic pathway. to evaluate changes in fruit quality during chilling, we analyzed mango "keitt" fruit peel volatiles. gc-ms analysis revealed significant modulations in fruit volatiles during ...201728075566
stable isotope dilution assay (sida) and hs-spme-gcms quantification of key aroma volatiles for fruit and sap of australian mango cultivars.reported herein is a high throughput method to quantify in a single analysis the key volatiles that contribute to the aroma of commercially significant mango cultivars grown in australia. the method constitutes stable isotope dilution analysis (sida) in conjunction with headspace (hs) solid-phase microextraction (spme) coupled with gas-chromatography mass spectrometry (gcms). deuterium labelled analogues of the target analytes were either purchased commercially or synthesised for use as internal ...201727979249
on the biology of the colombian fluted scale, crypticerya multicicatrices kondo & unruh (hemiptera: monophlebidae).the colombian fluted scale crypticerya multicicatrices kondo & unruh (hemiptera: monophlebidae) is a polyphagous insect pest native to continental colombia and reported on 148 species, mainly palms (arecaceae); mango, mangifera indica (anacardiaceae); and leguminous trees and shrubs (fabaceae). the biology and ecological parameters of c. multicicatrices were investigated using as a host plant caesalpinia pluviosa var. peltophoroides (fabaceae) under two environmental conditions: semifield (max t ...201727975194
molecular cloning, characterization, and expression of misoc1: a homolog of the flowering gene suppressor of overexpression of constans1 from mango (mangifera indica l).mads-box transcription factor plays a crucial role in plant development, especially controlling the formation and development of floral organs. mango (mangifera indica l) is an economically important fruit crop, but its molecular control of flowering is largely unknown. to better understand the molecular basis of flowering regulation in mango, we isolated and characterized the misoc1, a putative mango orthologs for the arabidopsis suppressor of overexpression of constans1/agamous-like 20 (soc1/a ...201627965680
production of auroxanthins from violaxanthin and 9-cis-violaxanthin by acidic treatment and the antioxidant activities of violaxanthin, 9-cis-violaxanthin, and auroxanthins.violaxanthin and 9-cis-violaxanthin (major epoxycarotenoids in fruit) were prepared from mango fruit, purified, and converted to other carotenoids under acidic conditions. the resulting carotenoid structures were then analyzed in detail. not only violaxanthin but also 9-cis-violaxanthin were found to be converted to (8s,8's)-, (8s,8'r)-, and (8r,8'r)-auroxanthin at an approximate ratio of 4:6:1. antioxidant activities of violaxanthin, 9-cis-violaxanthin, (8s,8's)-auroxanthin, and (8s,8'r)-auroxa ...201627960276
polyphenolics from mango (mangifera indica l.) suppress breast cancer ductal carcinoma in situ proliferation through activation of ampk pathway and suppression of mtor in athymic nude mice.the objective of this study was to assess the underlying mechanisms of mango polyphenol decreased cell proliferation and tumor volume in ductal carcinoma in situ breast cancer. we hypothesized that mango polyphenols suppress signaling along the akt/mtor axis while up-regulating ampk. to test this hypothesis, mango polyphenols (0.8 mg gallic acid equivalents per day) and pyrogallol (0.2 mg/day) were administered for 4 weeks to mice xenografted with mcf10dcis.com cells subcutaneously (n=10 per gro ...201727951515
image based mango fruit detection, localisation and yield estimation using multiple view geometry.this paper presents a novel multi-sensor framework to efficiently identify, track, localise and map every piece of fruit in a commercial mango orchard. a multiple viewpoint approach is used to solve the problem of occlusion, thus avoiding the need for labour-intensive field calibration to estimate actual yield. fruit are detected in images using a state-of-the-art faster r-cnn detector, and pair-wise correspondences are established between images using trajectory data provided by a navigation sy ...201627854271
data on enterobacteria activity on biofilm formation at surface mango fruit (mangifera indica l.) cv ataulfo.abiotic factors influenced the capacity of the strains to form biofilms. classification of the adhesion type is related with the optical density measured on the biofilm formation of tested strains. the relationship between the biofilm formation in real values with theoretical values of the strains was used to determine the mechanism involved during mixed cultures.201627833933
antidiabetic effects of mangifera indica kernel flour-supplemented diet in streptozotocin-induced type 2 diabetes in rats.our previous report showed that mangifera indica kernel flour (mikf) is a rich source of pharmacologically important flavonoids and phenolic acids; and that its methanolic extract inhibits some key enzymes linked to the pathology and complications of type 2 diabetes (t2d) in vitro. hence, this study evaluated the antidiabetic effects of 10% and 20% mikf-supplemented diets in t2d in rats. t2d was induced in rats using a high-fat diet (hfd), low-dose streptozotocin (hfd/stz) model, by feeding the ...201627826432
deciphering the costs of reproduction in mango - vegetative growth matters.irregular fruit production across successive years is a major issue that limits the profitability of most temperate and tropical fruit crops. it is particularly affected by the reciprocal relationships between vegetative and reproductive growth. the concept of the costs of reproduction is defined in terms of losses in the potential future reproductive success caused by current investment in reproduction. this concept, developed in ecology and evolutionary biology, could provide a methodological ...201627818665
transcriptome dynamics in mango fruit peel reveals mechanisms of chilling stress.cold storage is considered the most effective method for prolonging fresh produce storage. however, subtropical fruit is sensitive to cold. symptoms of chilling injury (ci) in mango include red and black spots that start from discolored lenticels and develop into pitting. the response of 'keitt' mango fruit to chilling stress was monitored by transcriptomic, physiological, and microscopic analyses. transcriptomic changes in the mango fruit peel were evaluated during optimal (12°c) and suboptimal ...201627812364
mangiferin modulation of metabolism and metabolic syndrome.the recent emergence of a worldwide epidemic of metabolic disorders, such as obesity and diabetes, demands effective strategy to develop nutraceuticals or pharmaceuticals to halt this trend. natural products have long been and continue to be an attractive source of nutritional and pharmacological therapeutics. one such natural product is mangiferin (mgf), the predominant constituent of extracts of the mango plant mangifera indica l. reports on biological and pharmacological effects of mgf increa ...201627534809
the potential role of mangiferin in cancer treatment through its immunomodulatory, anti-angiogenic, apoptopic, and gene regulatory effects.mangiferin (1,3,6,7-tetrahydroxyxanthone-c2-β-d-glucoside) is a natural bioactive xanthonoid that can be found in many plant species, among which the mango tree (mangifera indica l), a plant widely used in the traditional medicinal, is one of its primary sources. the use of mangiferin for cancer treatment has attracted the attention of research groups around the world. single administration of mangiferin or in combination with known anticancer chemicals has shown the potential benefits of this m ...201627219221
low-temperature conditioning induces chilling tolerance in stored mango fruit.in this study, mango fruit were pre-treated with low-temperature conditioning (ltc) at 12°c for 24h, followed by refrigeration at 5°c for 25days before removal to ambient temperature (25°c) to investigate the effects and possible mechanisms of ltc on chilling injury (ci). the results showed that ltc effectively suppressed the development of ci in mango fruit, accelerated softening, and increased the soluble solids and proline content. furthermore, ltc reduced electrolyte leakage, and levels of m ...201727765262
data on changes in the fatty acid composition during fruit development and ripening of three mango cultivars (alphonso, pairi and kent) varying in lactone content.data in this article presents fatty acid composition of three mango cultivars; alphonso, pairi and kent through fruit development and ripening. change in the ω-6 and ω-3 fatty acids level during mango fruit development and ripening is depicted. also, data on aroma volatile 'lactones' composition from pulp and skin tissues of these cultivars at their ripe stage, respectively is provided. statistical data is also shown, which correlates modulation in lactone content with that of fatty acid composi ...201627722190
evaluation of four protein extraction methods for proteomic analysis of mango peel.the peel of mango (mangifera indica l.) is a special plant tissue that contains many compounds that interfere with protein extraction. a successful separation with two-dimensional electrophoresis (2-de) is the key step for proteomic analysis. to evaluate the efficiencies of mango peel protein extraction for 2-de, four extraction methods were tested: 1) 2-d clean-up kit, 2) trichloroacetic acid/acetone precipitation, 3) phenol extraction, 4) phenol with methanol/ammonium acetate precipitation. th ...201627706672
benzophenones from mango leaves exhibit α-glucosidase and no inhibitory activities.mango (mangifera indica l.) is a succulent tropical fruit. bioactive phytochemical investigation has been carried out to the leaves of mango. three new benzophenone glycosides, along with 14 known compounds, were purified and identified. the novel benzophenones were elucidated to be 2,4,4',6-tetrahydroxy-3'-methoxybenzophenone-3-c-β-d-glucopyranoside (1), 4,4',6-trihydroxybenzophenone-2-o-α-l-arabinofuranoside (7), and 4',6-dihydroxy-4-methoxybenzophenone-2-o-(2″),3-c-(1″)-1″-desoxy-α-l-fructofu ...201627643634
construction of a high-density genetic map based on large-scale marker development in mango using specific-locus amplified fragment sequencing (slaf-seq).genetic maps are particularly important and valuable tools for quantitative trait locus (qtl) mapping and marker assisted selection (mas) of plant with desirable traits. in this study, 173 f1 plants from a cross between mangifera indica l. "jin-hwang" and m. indica l. "irwin" and their parent plants were subjected to high-throughput sequencing and specific-locus amplified fragment (slaf) library construction. after preprocessing, 66.02 gb of raw data containing 330.64 m reads were obtained. a to ...201627625670
potential effect of olea europea leaves, sonchus oleraceus leaves and mangifera indica peel extracts on aromatase activity in human placental microsomes and cyp19a1 expression in mcf-7 cell line: comparative study.aromatase inhibitors (ais) provide novel approaches to the adjuvant therapy for postmenopausal women with estrogen-receptor-positive (er+) breast cancers. in this study, different plant extracts from olea europaea leaves (ole), sonchus oleraceus l. (soe) and mangifera indica peels (mpe) were prepared to identify phytoconstituents and measure antioxidant capacities. the effects of these three extracts on aromatase activity in human placental microsomes were evaluated. additionally, the effects of ...201627585256
mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model.epidemiological studies reveal that metabolic disorders, and specifically type 2 diabetes (t2d), are relevant risk factors to develop alzheimer's disease (ad) and vascular dementia (vad), the most common causes of dementia. ad patients are in a tremendous need of new therapeutic options because of the limited success of available treatments. natural polyphenols, and concretely mangifera indica linn extract (mgf), have been reported to have antiinflammatory, antioxidant and antidiabetic activitie ...201727537110
pyrogallol, an absorbable microbial gallotannins-metabolite and mango polyphenols (mangifera indica l.) suppress breast cancer ductal carcinoma in situ proliferation in vitro.mango is rich in bioactive absorbable polyphenols, but also contains considerable amounts of unabsorbable gallotannins at varying degrees of polymerization. gallotannins are not absorbable upon consumption and have rarely been considered in the discussion of health benefits of polyphenols. therefore, the objective of this study was to investigate the anti-proliferative activities of the major microbial metabolite of gallotannins, pyrogallol (pg) and a low molecular weight fraction of mango (mang ...201627491891
modulatory effect of mangifera indica against carbon tetrachloride induced kidney damage in rats.there is little scientific evidence on the local use of mangifera indica in kidney diseases. this study investigated the reno-modulatory roles of the aqueous stem bark extract of mangifera indica (miase) against ccl4-induced renal damage. rats were treated intragastrically with 125, 250 and 500 mg/kg/day miase for 7 days before and after the administration of ccl4 (3 ml/kg of 30% ccl4, i.p.). serum levels of electrolytes (na+, k+, cl(-), hco3(-)), urea and creatinine were determined. renal tissu ...201527486379
chemical constituents of mangifera indica and their antiausterity activity against the panc-1 human pancreatic cancer cell line.human pancreatic cancer cell lines such as panc-1 have an altered metabolism, enabiling them to tolerate and survive under extreme conditions of nutrient starvation. the search for candidates that inhibit their viability during nutrition starvation represents a novel antiausterity strategy in anticancer drug discovery. a methanol extract of the bark of mangifera indica was found to inhibit the survival of panc-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions with ...201627466882
long-term mangiferin extract treatment improves central pathology and cognitive deficits in app/ps1 mice.alzheimer's disease (ad) is the most common cause of dementia; however, available treatments have had limited success. therefore ad patients are in tremendous need of new pharmacological approaches that may delay or slow the progression of the disease. in addition to the classical neuropathological features, immunological and inflammatory processes are also involved in ad pathogenesis. naturally occurring compounds, such as mangifera indica linn (mgf) extracts have previously been shown to signi ...201727443159
the effect of blow flies (diptera: calliphoridae) on the size and weight of mangos (mangifera indica l.).pollination has a great effect on the yield of fruit trees. blow flies are considered as an effective pollinator compared to hand pollination in fruit orchards. therefore, this study was designed to evaluate the effect of different pollination methods in mango orchards.201627441107
mangiferin inhibits macrophage classical activation via downregulating interferon regulatory factor 5 expression.mangiferin is a natural polyphenol and the predominant effective component of mangifera indica linn. leaves. for hundreds of years, mangifera indica linn. leaf has been used as an ingredient in numerous traditional chinese medicine preparations for the treatment of bronchitis. however, the pharmacological mechanism of mangiferin in the treatment of bronchitis remains to be elucidated. macrophage classical activation is important role in the process of bronchial airway inflammation, and interfero ...201627277156
potentials of mangifera indica in the treatment of depressive-anxiety disorders: possible mechanisms of action.mangifera indica (anacardiaceae) is an important herb in the traditional african and ayurvedic medicines. the stem barks are used in the treatment of hypertension, insomnia, tumour, depression, rheumatism and as a tonic. this study was carried out to investigate antidepressant- and anxiolytic-like effect of the hydroethanol stem bark extract of m. indica (hemi) in mice.201627276531
the standard aqueous stem bark extract of mangifera indica l. inhibits toxic pla2 - nn-xib-pla2 of indian cobra venom.the aqueous extract of mangifera indica is known to possess diverse medicinal properties, which also includes anti-snake venom activities. however, its inhibitory potency and mechanism of action on multi-toxic snake venom phospholipases a2s are still unknown. therefore, the objective of this study was to evaluate the modulatory effect of standard aqueous bark extract of m. indica on nn-xib-pla2 of indian cobra venom. the in vitro spla2, in situ hemolytic and in vivo edema inhibition effect were ...201627275129
molecular and morphological diversity in locally grown non-commercial (heirloom) mango varieties of north india.mango (mangifera indica l.) has been cultivated and conserved in different agro-ecologies including malihabad region in northern part of india, that is well known for housing diverse types (heirloom and commercial varieties). in the present study, 37 mango types comprising of 27 heirloom varieties from malihabad region and 10 commercial varieties grown in north and eastern india were assessed for morphological attributes and molecular diversity. the employed ssr markers amplified 2-13 alleles in ...201627097441
single nucleotide polymorphism analysis reveals heterogeneity within a seedling tree population of a polyembryonic mango cultivar.within a polyembryonic mango seedling tree population, the genetic background of individuals should be identical because vigorous plants for cultivation are expected to develop from nucellar embryos representing maternal clones. due to the fact that the mango cultivar 'hôi' is assigned to the polyembryonic ecotype, an intra-cultivar variability of ethylene receptor genes was unexpected. ethylene receptors in plants are conserved, but the number of receptors or receptor isoforms is variable regar ...201627093244
mangiferin: a promising anticancer bioactive.of late, several biologically active antioxidants from natural products have been investigated by the researchers in order to combat the root cause of carcinogenesis, in other words, oxidative stress. mangiferin, a therapeutically active c-glucosylated xanthone, is extracted from pulp, peel, seed, bark and leaf of mangifera indica. these polyphenols of mangiferin exhibit antioxidant properties and tend to decrease the oxygen-free radicals, thereby reducing the dna damage. indeed, its capability ...201627088726
factors affecting ethylene and carbon dioxide concentrations during ripening: incidence on final dry matter, total soluble solids content and acidity of mango fruit.ripening of climacteric fruits is associated with pronounced changes in fruit gas composition caused by a concomitant rise in respiration and ethylene production. there is a discrepancy in the literature since some authors reported that changes in fruit gas compositions differ in attached and detached fruits. this study presents for the first time an overview of pre- and post-harvest factors that lead to variations in the climacteric respiration and ethylene production, and attempts to determine ...201627085177
mango polyphenolics reduce inflammation in intestinal colitis-involvement of the mir-126/pi3k/akt/mtor axis in vitro and in vivo.this study sought to elucidate the mechanisms underlying the anti-inflammatory effect of mango (mangifera indica l.) polyphenolics containing gallic acid and gallotanins, and the role of the mir-126/pi3k/akt/mtor signaling axis in vitro and in vivo. polyphenolics extracted from mango (var. keitt) were investigated in lipopolysaccharide (lps)-treated ccd-18co cells. rats received either a beverage with mango polyphenolics or a control beverage, and were exposed to three cycles of 3% dextran sodiu ...201727061150
dominant viral pathologies in the extensive and semi-intensive animal breeding and their treatment mode in ethno veterinary medicine in benin.this study aims to identify the dominant viral animal pathologies and to list the traditional recipes used by the breeders for their treatment.201527047056
molecular cloning and characterization of o-methyltransferase from mango fruit (mangifera indica cv. alphonso).flavour of ripe alphonso mango is invariably dominated by the de novo appearance of lactones and furanones during ripening. of these, furanones comprising furaneol (4-hydroxy-2,5-dimethyl-3(2h)-furanone) and mesifuran (2,5-dimethyl-4-methoxy-3(2h)-furanone) are of particular importance due to their sweet, fruity caramel-like flavour characters and low odour detection thresholds. we isolated a 1056 bp complete open reading frame of a cdna encoding s-adenosyl-l-methionine-dependent o-methyltransfe ...201627039187
comparison of anti-inflammatory mechanisms of mango (mangifera indica l.) and pomegranate (punica granatum l.) in a preclinical model of colitis.tannin-rich fruits have been evaluated as alternative prevention strategies for colorectal cancer based on their anti-inflammatory properties. this study compared tannin-rich preparations from mango (rich in gallotannins) and pomegranate (rich in ellagitannins) in the dextran sodium sulfate-induced colitis model.201627028006
chemical profile of mango (mangifera indica l.) using electrospray ionisation mass spectrometry (esi-ms).mangifera indica l., mango fruit, is consumed as a dietary supplement with purported health benefits; it is widely used in the food industry. herein, the chemical profile of the ubá mango at four distinct maturation stages was evaluated during the process of growth and maturity using negative-ion mode electrospray ionisation fourier transform ion cyclotron resonance mass spectrometry (esi(-)ft-icr ms) and physicochemical characterisation analysis (total titratable acidity (ta), total soluble sol ...201626988473
the anti-inflammatory activity of standard aqueous stem bark extract of mangifera indica l. as evident in inhibition of group ia spla2.the standard aqueous stem bark extract is consumed as herbal drink and used in the pharmaceutical formulations to treat patients suffering from various disease conditions in cuba. this study was carried out to evaluate the modulatory effect of standard aqueous bark extract of m. indica on group ia spla2. m. indica extract, dose dependently inhibited the gia spla2 (nn-xia-pla2) activity with an ic50 value 8.1 µg/ml. m. indica extract effectively inhibited the indirect hemolytic activity up to 98% ...201626959323
metabolite profiling of the ripening of mangoes mangifera indica l. cv. 'tommy atkins' by real-time measurement of volatile organic compounds.real-time profiling of mango ripening based on proton transfer reaction-time of flight-mass spectrometry (ptr-tof-ms) of small molecular weight volatile organic compounds (vocs), is demonstrated using headspace measurements of 'tommy atkins' mangoes. voc metabolites produced during the ripening process were sampled directly, which enabled simultaneous and rapid detection of a wide range of compounds. headspace measurements of 'keitt' mangoes were also conducted for comparison. a principle compon ...201726937226
neomangiferin modulates the th17/treg balance and ameliorates colitis in mice.anemarrhena asphodeloides (liliaceae family) and mangifera indica l. (anacardiaceae family) contain neomangiferin as the main active constituent and have been used to treat inflammation, asthma, and pain.201626926174
mangiferin protect myocardial insults through modulation of mapk/tgf-β pathways.mangiferin, a xanthone glycoside isolated from leaves of mangifera indica (anacardiaceae) is known to modulate many biological targets in inflammation and oxidative stress. the present study was designed to investigate whether mangiferin exerts protection against myocardial ischemia-reperfusion (ir) injury and possible role of mitogen activated protein kinase (mapks) and transforming growth factor-β (tgf-β) pathways in its cardioprotection. male albino wistar rats were treated with mangiferin (4 ...201626921754
enzymatic synthesis of acylphloroglucinol 3-c-glucosides from 2-o-glucosides using a c-glycosyltransferase from mangifera indica.a green and cost-effective process for the convenient synthesis of acylphloroglucinol 3-c-glucosides from 2-o-glucosides was exploited using a novel c-glycosyltransferase (micgtb) from mangifera indica. compared with previously characterized cgts, micgtb exhibited unique de-o-glucosylation promiscuity and high regioselectivity toward structurally diverse 2-o-glucosides of acylphloroglucinol and achieved high yields of c-glucosides even with a catalytic amount of uridine 5'-diphosphate (udp). the ...201626918309
kinetics and quality of microwave-assisted drying of mango (mangifera indica).the effect of microwave-assisted convective air-drying on the drying kinetics and quality of mango was evaluated. both microwave power and pretreatment time were significant factors but the effect of power was more profound. increase in microwave power and pretreatment time had a positive effect on drying time. the nonenzymatic browning index of the fresh samples increased from 0.29 to 0.60 while the ascorbic acid content decreased with increase in microwave power and time from 3.84 mg/100g to 1 ...201626904667
dissipation kinetics and risk assessment of thiamethoxam and dimethoate in mango.thiamethoxam and dimethoate are two insecticides used to control hoppers and inflorescence midges in mango. thiamethoxam (0.008 and 0.016%) and dimethoate (0.06 and 0.12%) were sprayed on dashehari mango trees during the pre-mature stage of fruit (first week of may) to study their dissipation kinetics and risk assessment in mango fruit. thiamethoxam dissipated in fruit from 1.93 and 3.71 mg kg(-1) after 2 h of spraying to 0.08 and 0.13 mg kg(-1) after 20 days of spraying at single and double dos ...201626879986
in vitro anticancer potential of baco3 nanoparticles synthesized via green route.green synthesis of nanoparticles is a growing research area because of their potential applications in nanomedicine. barium carbonate nanoparticles (baco3 nps) were synthesized using an aqueous extract of mangifera indica seed as a reducing agent. these particles were characterized by fourier transform infrared spectroscopy (ft-ir), x-ray diffraction (xrd), transmission electron microscopy (tem), selected area electron diffraction (saed), energy-dispersive-x-ray (edx) and x-ray photoelectron spe ...201626803273
inter-regional mating compatibility among bactrocera dorsalis populations in thailand (diptera,tephritidae).mating compatibility among recently colonized (wildish) populations of bactrocera dorsalis (hendel) from different geographic origins in thailand was assessed through inter-regional mating tests. outdoor octagonal nylon screen field cages containing single potted mango trees (mangifera indica l.) were used. sexual compatibility was determined using the index of sexual isolation (isi), the male relative performance index (mrpi), and the female relative performance index (frpi). the isi values ind ...201526798264
change in the chemical profile of mangifera indica leaves after their metabolism in the tropidacris collaris grasshopper.this present work addresses research on the discovery of new compounds from natural sources. it is based on a study of mangifera indica leaf metabolism by the tropidacris collaris grasshopper. we found that the grasshopper hydrolyzed the flavonoid isoquercitrin to quercetin when the o-glycosidic bond was broken and sugar released as a probable energy source for the insect. there was not, however, hydrolysis of the major compound in the leaves, mangiferin, which contains the c-glycosidic bond. al ...201526749802
spatial variance of physicochemical properties within mangos and the effect of initial ripeness stage on the quality of fresh-cut mangos.this study aimed to assess the spatial variation in physicochemical properties within individual mangos, as well as to investigate the influence of initial ripeness level on physicochemical characteristics of fresh-cut mangos. individual mangos were evaluated at 12 specific flesh positions in the inner and outer sides. mango cubes of 1.5 cm prepared from three firmness stages were monitored for changes during 9 days of storage at 5 °c.201626699838
mangiferin alleviates lipopolysaccharide and d-galactosamine-induced acute liver injury by activating the nrf2 pathway and inhibiting nlrp3 inflammasome activation.mangiferin, a glucosylxanthone from mangifera indica, has been reported to have anti-inflammatory effects. however, the protective effects and mechanisms of mangiferin on liver injury remain unclear. this study aimed to determine the protective effects and mechanisms of mangiferin on lipopolysaccharide (lps) and d-galactosamine (d-galn)-induced acute liver injury. mangiferin was given 1h after lps and d-galn treatment. the results showed that mangiferin inhibited the levels of serum alt, ast, il ...201626668000
optimisation of gellan gum edible coating for ready-to-eat mango (mangifera indica l.) bars.the optimisation of an edible coating based on low acyl (l)/high acyl (h) gellan gum for ready-to-eat mango bars was performed through a central composite rotatable design (ccrd). the independent variables were the concentration of gellan (l/h90/10) and the concentration of ca(2+) in the coating solution, as well as the storage time after coating application. the response variables studied were the coating thickness, mango bars firmness, syneresis, and colour alterations. gellan concentration wa ...201626657585
urinary metabolites from mango (mangifera indica l. cv. keitt) galloyl derivatives and in vitro hydrolysis of gallotannins in physiological conditions.the absorption, metabolism, and excretion of mango galloyl derivatives (gd) has not yet been investigated in humans, and studies investigating repeated dosages of polyphenols are limited.201626640139
factors influencing oral bioavailability of thai mango seed kernel extract and its key phenolic principles.mango seed kernel extract (mske) and its key components (gallic acid, ga; methyl gallate, mg; and pentagalloyl glucopyranose, pgg) have generated interest because of their pharmacological activities. to develop the potential use of the key components in mske as natural therapeutic agents, their pharmacokinetic data are necessary. therefore, this study was performed to evaluate the factors affecting their oral bioavailability as pure compounds and as components in mske. the in vitro chemical stab ...201526633325
antihepatotoxic efficacy of mangifera indica l. polysaccharides against cyclophosphamide in rats.the present study aims to evaluate the possible protective role of polysaccharides extracted from the egyptian mango mangifera indica l. (mps) and/or silymarine against cyclophosphamide (cp) toxicity in male albino rats. the mps and/or silymarin significantly decreased the activities of serum asat and alat. however, mps (1000 mg/kg) normalized their activities towards the normal levels recording 28.75 and 78.75 u/ml respectively. the recorded data also showed the antioxidant effect of mps by dec ...201626615121
ethanol extract of mango (mangifera indica l.) peel inhibits α-amylase and α-glucosidase activities, and ameliorates diabetes related biochemical parameters in streptozotocin (stz)-induced diabetic rats.peel is a major by-product during processing of mango fruit into pulp. recent report indicates that the whole peel powder ameliorated diabetes. in the present study, ethanolic extract of mango peel was analysed for its bioactive compounds, evaluated for α-amylase and α-glucosidase inhibitory properties, oral glucose tolerance test, antioxidant properties, plasma insulin level and biochemical parameters related to diabetes. in addition to gallic and protocatechuic acids, the extract also had chlo ...201526604360
in vitro activation of enos by mangifera indica (careless™) and determination of an effective dosage in a randomized, double-blind, human pilot study on microcirculation.mangifera indica fruit preparation (careless™) activates the evolutionary conserved metabolic sensors sirtuin 1 and adenosine monophosphate-activated protein kinase, which have been identified as playing a key role in microcirculation and endothelial function. here, an acute effect of a single dose of 100 mg or 300 mg careless™ on microcirculation was investigated in a randomized, double-blind, crossover pilot study in ten healthy women to determine the effective dosage. microcirculation and end ...201626584454
mango (mangifera indica l.) germplasm diversity based on single nucleotide polymorphisms derived from the transcriptome.germplasm collections are an important source for plant breeding, especially in fruit trees which have a long duration of juvenile period. thus, efforts have been made to study the diversity of fruit tree collections. even though mango is an economically important crop, most of the studies on diversity in mango collections have been conducted with a small number of genetic markers.201526573148
pollution response score of tree species in relation to ambient air quality in an urban area.multivariate statistical techniques were employed on twelve leaf traits in four selected common tree species (mangifera indica l., polyalthia longifolia sonn., ficus benghalensis l. and psidium guajava l.) to evaluate their responses with respect to major air pollutants in an urban area. discriminant analysis (da) identified chlorophyll/carotenoid ratio, leaf dry matter content, carotenoids, net water content and ascorbic acid as the major discriminating leaf traits, which varied maximally with ...201626508430
identification of target proteins of mangiferin in mice with acute lung injury using functionalized magnetic microspheres based on click chemistry.prevention of the occurrence and development of inflammation is a vital therapeutic strategy for treating acute lung injury (ali). increasing evidence has shown that a wealth of ingredients from natural foods and plants have potential anti-inflammatory activity. in the present study, mangiferin, a natural c-glucosyl xanthone that is primarily obtained from the peels and kernels of mango fruits and the bark of the mangifera indica l. tree, alleviated the inflammatory responses in lipopolysacchari ...201526488336
impact of ph and total soluble solids on enzyme inactivation kinetics during high pressure processing of mango (mangifera indica) pulp.this study was undertaken with an aim to enhance the enzyme inactivation during high pressure processing (hpp) with ph and total soluble solids (tss) as additional hurdles. impact of mango pulp ph (3.5, 4.0, 4.5) and tss (15, 20, 25 °brix) variations on the inactivation of pectin methylesterase (pme), polyphenol oxidase (ppo), and peroxidase (pod) enzymes were studied during hpp at 400 to 600 mpa pressure (p), 40 to 70 °c temperature (t), and 6- to 20-min pressure-hold time (t). the enzyme inact ...201526444301
design and develop a nondestructive infrared spectroscopy instrument for assessment of mango (mangifera indica) quality.a portable infrared spectroscopy system has been designed and developed for assessment of quality of mango fruit. this paper describes the design and development of a fruit quality grading device using reflectance mode optical sensor. the experiment was conducted to obtain the best results from the system and the device was correlated according to the measured output. in the experiment, several samples of mango fruits have been monitored for six days to study the relation how fruit quality incre ...201426396317
effect of postharvest ultraviolet-c treatment on the proteome changes in fresh cut mango (mangifera indica l. cv. chokanan).postharvest treatments of fruits using techniques such as ultraviolet-c have been linked with maintenance of the fruit quality as well as shelf-life extension. however, the effects of this treatment on the quality of fruits on a proteomic level remain unclear. this study was conducted in order to understand the response of mango fruit to postharvest uv-c irradiation.201626350493
probing the catalytic promiscuity of a regio- and stereospecific c-glycosyltransferase from mangifera indica.the catalytic promiscuity of the novel benzophenone c-glycosyltransferase, micgt, which is involved in the biosynthesis of mangiferin from mangifera indica, was explored. micgt exhibited a robust capability to regio- and stereospecific c-glycosylation of 35 structurally diverse druglike scaffolds and simple phenolics with udp-glucose, and also formed o- and n-glycosides. moreover, micgt was able to generate c-xylosides with udp-xylose. the ogt-reversibility of micgt was also exploited to generat ...201526331569
[textual research on amara (mangifera indica linn), butea monsperma (lam) kuntze, and ferula asatoitida l].in the buddhist canons, there are lots of medicines imported from abroad recorded. the dictionary works of such buddhist canons give detailed annotations and explanations to all these foreign medicines, from which we can investigate the features of all these medicines. it is also clear that these three medicines were imported into china no later than the tang dynasty. amara was originally grown in the xi yu (western region) , now called mango. its form and connotation appeared no later than the ...201526268251
describing quality and sensory attributes of 3 mango (mangifera indica l.) cultivars at 3 ripeness stages based on firmness.to determine the ideal ripening stage for consumption of the mango cultivars, "ataulfo," "haden," and "tommy atkins"; fruits at 3 flesh firmness levels (ripeness stages) were evaluated by a trained panel using descriptive analysis after instrumental measurements were made. after harvest, all fruits were ripened to allow softening and quality and sensory attribute changes. ripening changes during softening of ataulfo mangos were expressed by a characteristic increase in the perception of "tropica ...201526257310
validation of ethnomedicinal potential of tinospora cordifolia for anticancer and immunomodulatory activities and quantification of bioactive molecules by hptlc.tinospora cordifolia (willd.) miers ex hook. f. & thomas. (menispermaceae) is one of the most widely used plants in various traditional medicinal systems including "ayurveda". the plant is used for the treatment of jaundice, rheumatism, urinary disorder, skin diseases, diabetes and anemia. the phytoconstituents present in the plant belongs to different class of compounds such as alkaloids, diterpenoids lactones, glycosides, steroids, phenol, aliphatic compounds and polysaccharides.201526253577
pollination services of mango flower pollinators.measuring wild pollinator services in agricultural production is very important in the context of sustainable management. in this study, we estimated the contribution of native pollinators to mango fruit set production of two mango cultivars mangifera indica (l). cv. 'sala' and 'chok anan'. visitation rates of pollinators on mango flowers and number of pollen grains adhering to their bodies determined pollinator efficiency for reproductive success of the crop. chok anan failed to produce any fru ...201526246439
antioxidant and enzymatic responses to oxidative stress induced by pre-harvest water supply reduction and ripening on mango (mangifera indica l. cv. 'cogshall') in relation to carotenoid content.the effects of a reduction in water supply during fruit development and postharvest fruit ripening on the oxidative status and the antioxidant defense system were studied in the mango fruit (mangifera indica l.) cv. cogshall. changes in non-enzymatic (ascorbate) and enzymatic (sod, cat, apx, mdhar, dhar and gr) antioxidants, as well as oxidative parameters (h2o2 and mda) and major carotenoids, were measured in unripe and ripe fruits from well-irrigated and non-irrigated trees. under non-limiting ...201526232564
mangiferin inhibits renal urate reabsorption by modulating urate transporters in experimental hyperuricemia.mangiferin, a natural glucosyl xanthone from the leaves of mangifera indica l., was previously shown to exert potent hypouricemic effects associated with inhibition of the activity of xanthine dehydrogenase/oxidase. the present study aimed to evaluate its uricosuric effect and possible molecular mechanisms underlying the renal urate transporters responsible for urate reabsorption in vivo. mangiferin (1.5-24.0 mg/kg) was administered intragastrically to hyperuricemic mice and rats induced by the ...201526228630
sequence diversity and differential expression of major phenylpropanoid-flavonoid biosynthetic genes among three mango varieties.mango fruits contain a broad spectrum of phenolic compounds which impart potential health benefits; their biosynthesis is catalysed by enzymes in the phenylpropanoid-flavonoid (pf) pathway. the aim of this study was to reveal the variability in genes involved in the pf pathway in three different mango varieties mangifera indica l., a member of the family anacardiaceae: kensington pride (kp), irwin (iw) and nam doc mai (ndm) and to determine associations with gene expression and mango flavonoid p ...201526220670
development of est-ssr and trap markers from transcriptome sequencing data of the mango.mango is one of the most commercially important fruit crops in tropical and subtropical regions. to increase the efficiency of breeding strategies, two est-derived marker systems were developed in the present study using information from the mango fruit transcriptome. using simple sequence repeats, 218 of 230 primer pairs showed stable amplification for 7 mango genotypes with amplicons ranging from 84 to 160 bp; 93 of the primer pairs yielded polymorphic products. the proportion of polymorphic b ...201526214472
mangiferin mitigates gastric ulcer in ischemia/ reperfused rats: involvement of ppar-γ, nf-κb and nrf2/ho-1 signaling pathways.mangiferin (mf), a xanthonoid from mangifera indica, has been proved to have antisecretory and antioxidant gastroprotective effects against different gastric ulcer models; however, its molecular mechanism has not been previously elucidated. therefore, the aim of this study was to test its modulatory effect on several signaling pathways using the ischemia/reperfusion model for the first time. animals were treated with mf, omeprazole (omp), and the vehicle. the mechanistic studies revealed that mf ...201526196679
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