Publications

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studies on certain biological characteristics of malleomyces mallei and malleomyces pseudomallei: i. morphology, cultivation, viability, and isolation from contaminated specimens. 194816561426
studies on certain biological characteristics of malleomyces mallei and malleomyces pseudomallei: ii. virulence and infectivity for animals. 194816561427
studies on certain biological characteristics of malleomyces mallei and malleomyces pseudomallei; morphology, cultivation, viability, and isolation from contaminated specimens. 194818917669
studies on certain biological characteristics of malleomyces mallei and malleomyces pseudomallei; virulence and infectivity for animals. 194818917670
[note on the action in vitro of chloramphenicol on whitmore's bacillus]. 195014777406
melioidosis in sheep in queens land; a description of the causal organism. 195014838792
immunologic studies with malleomyces mallei and malleomyces pseudomallei; serological relationships between m. mallei and m. pseudomallei. 195015402290
immunologic studies with malleomyces mallei and malleomyces pseudomallei, agglutination and complement fixation tests in man and laboratory animals. 195015402291
[an exceptional differential diagnosis: malleomyces pseudomallei and bacillus laterosporus]. 195212986355
[the chromogenic power of malleomyces pseudomallei]. 195213017197
[study of the biochemical properties of malleomyces pseudomallei]. 195313124940
growth of malleomyces pseudomallei in simple chemically defined media. 195413143003
studies on malleomyces pseudomallei isolated from melioidosis originating in the western hemisphere. 195413207052
characteristics of a strain of malleomyces pseudomallei from chronic melioidosis. 195413207053
toxin produced by malleomyces pseudomallei. 195514384863
staining bacterial smears with fluorescent antibody. i. general methods for malleomyces pseudomallei. 195613366928
staining bacterial smears with fluorescent antibody. ii. rapid detection of varying numbers of malleomyces pseudomallei in contaminated materials and infected animals. 195613366929
[antigenic constitution of malleomyces pseudomallei. ii. demonstration of the existence of m, k and o antigens and study of their immunological properties]. 195613373066
hexose oxidation by an enzyme system of malleomyces pseudomallei. 195613366964
enhancement of virulence of malleomyces pseudomallei. 195613331865
[antigenic structure of malleomyces pseudomallei. iii. method of extraction and early results of attempted purification of antigen k from the surface of bacteria cells]. 195713470458
glucose catabolism in malleomyces pseudomallei. 195713428711
an intracellular mortality-enhancing material from malleomyces pseudomallei. 195813549731
toxins of pseudomonas pseudomallei. i. production in vitro. 195813587482
toxins of pseudomonas pseudomallei. ii. characterization. 195813587483
melioidosis: pathogenesis and immunity in mice and hamsters. i. studies with virulent strains of malleomyces pseudomallei.the pathogenesis of acute respiratory melioidosis mice and hamsters is described. inhaled organisms giving rise to lesions seemed to be first engulfed by the mononuclear alveolar phagocytes, but in less than 1 day polymorphonuclear cells made their appearance. in spite of this defense reaction, the bacteria continued to multiply and their products caused focal necrosis. these foci enlarged and gave rise to septicemia, toxemia, and eventually death, which usually occurred in 3 to 10 days dependin ...195813481262
melioidosis: pathogenesis and immunity in mice and hamsters. ii. studies with avirulent strains of malleomyces pseudomallei. 195813583099
immunization with an induced avirulent auxotrophic mutant of pseudomonas pseudomallei. 195813598926
mortality-enhancing polypeptide constituents from pseudomonas pseudomallei. 195914416256
occurrence of poly-beta-hydroxybutyrate in pseudomonas pseudomallei. 196014416257
[serological analysis of the somatic antigen of malleomyces pseudomallei]. 196013809076
[isolation in tchad (central africa of 2 strains of malleomyces pseudomallei]. 196014435122
melioidosis: pathogenesis and immunity in mice and hamsters. iii. effect of vaccination with avirulent strains of pseudomonas pseudomallei on the resistance to the establishment and the resistance to the progress of respiratory melioidosis caused by virulent strains; all-or-none aspects of this disease. 196013814030
endotoxic properties of pseudomonas pseudomallei. 196113739546
complement fixation test in experimental clinical and subclinical melioidosis.nigg, clara (university of california, berkeley), and margaret m. johnston. complement fixation test in experimental clinical and subclinical melioidosis. j. bacteriol. 82:159-168. 1961.-soluble stable antigens prepared from pseudomonas pseudomallei gave 4+ complement fixation reactions in a dilution of 1 to 8,000 when tested with specific rabbit antiserum diluted 1 to 10,000. the complement fixation reaction was positive in 100% of experimentally infected rabbits 9 to 11 days postinfection. inf ...196113729013
effect of pseudomonas pseudomallei endotoxin on response to cholinergic stimuli in the rabbit. 196314073138
toxic lysolipoid: isolation from pseudomonas pseudomallei.a lipoid of low molecular weight, isolated from the supernatant fluid of cultures of pseudomonas pseudomallei, killed mice, but not rabbits, in doses comparable to those of the homologous lipopolysaccharide and also lysed sheep erythrocytes. in rabbits this lipoid failed to elicit primary dermal lesions, to prepare the skin for the local schwartzman reaction, or to induce antibody formation.196414191702
decreased permeability as the mechanism of arsenite resistance in pseudomonas pseudomallei.beppu, michiko (university of tokyo, tokyo, japan), and kei arima. decreased permeability as the mechanism of arsenite resistance in pseudomonas pseudomallei. j. bacteriol. 88:151-157. 1964.-the mechanism of arsenite resistance of pseudomonas pseudomallei strain 54, isolated from soil, was studied by use of radioactive arsenite. arsenite resistance was found to be related to decreased permeation of arsenite into the cells. p. pseudomallei 54 cells can accumulate arsenite, but the organisms grown ...196414197880
induction and mechanisms of arsenite resistance in pseudomonas pseudomallei.arima, kei (university of tokyo, tokyo, japan), and michiko beppu. induction and mechanisms of arsenite resistance in pseudomonas pseudomallei. j. bacteriol. 88:143-150. 1964.-pseudomonas pseudomallei strain 54, able to grow in the presence of 2 x 10(-2)m arsenite, was isolated from soil. after a short lag period, it grew at a normal growth rate. in the organisms grown with 10(-2)m arsenite, oxidation of alpha-ketoglutarate and other substrates proceeded in the presence of the same concentration ...196414197879
differentiation of exotoxin and other biologically active substances in pseudomonas pseudomallei filtrates.heckly, robert j. (university of california, berkeley). differentiation of exotoxin and other biologically active substances in pseudomonas pseudomallei filtrates. j. bacteriol. 88:1730-1736. 1964.-denaturing agents such as phenol, formaldehyde, and urea reduced lethal toxicity and proteolytic activity of partially purified preparations from pseudomonas pseudomallei at about the same rate. neither toxin nor enzyme was stable at ph 11, when the solution was adjusted with sodium hydroxide, but the ...196414240963
[the heat-stable precipitating antigen of whitmorella (=pseudomonas) pseudomallei]. 196514289971
[comparative action of malleomyces mallei, pseudomonas pseudomallei and pseudomonas aeruginosa on various nitrogen substances]. 19654953183
osteomyelitis due to pseudomonas pseudomallei. 19665952299
a comparative study of pseudomonas pseudomallei and bacillus mallei. 19665962362
isolation of pseudomonas pseudomallei from an aborted goat foetus. 19666007974
septic arthritis due to pseudomonas pseudomallei. 19676057646
[thermostable antigens of pseudomonas pseudomallei and of malleomyces mallei and their characteristics in common]. 19674961924
selection and rapid identification of pseudomonas pseudomallei from other gram-negative bacteria. 19684871604
[polysaccharide-containing complexes of malleomyces pseudomallei]. 19685733582
diagnostic criteria for differentiation of pseudomonads pathogenic for man.to determine the most useful diagnostic characters for the differentiation of pseudomonads pathogenic for man, including pseudomonas maltophilia (alcaligenes bookeri), p. stutzeri (bacillus denitrificans), p. pseudomallei (malleomyces pseudomallei), and apyocyanogenic strains of p. aeruginosa, a comparative examination was made of 58 strains of these bacilli for their morphological and biochemical characteristics. it was concluded that the criteria for differentiating these bacteria are type of ...19684879213
the control of experimental infection in mice produced by pseudomonas pseudomallei. 19695787609
melioidosis in malaysia. i. a method for isolation of pseudomonas pseudomallei from soil and surface water. 19695810796
melioidosis in malaysia. ii. distribution of pseudomonas pseudomallei in soil and surface water. 19695810797
melioidosis in malaysia. iv. intensive ecological study of carey island, selangor, for pseudomonas pseudomallei. 19694244150
pseudomonas pseudomallei: isolation from a chronic sternal abscess. 19695352785
[multiplication and virulence of septicemic and blood-infective agents in the organism of the infected animals and in their cadavers. xvi. study on models of pseudomonas pseudomallei experimental infections]. 19695398234
[biological and biochemical studies of the growth of virulence of several septicemic and blood-infective agents. vi. dehydrogenase activity of pseudomonas pseudomallei with various virulence]. 19695398239
melioidosis in malaysia. 3. antibodies to pseudomonas pseudomallei in the human population. 19695817889
pseudomonas pseudomallei: susceptibility to chemotherapeutic agents. 19705197996
nucleic acid similarities among pseudomonas pseudomallei, pseudomonas multivorans, and actinobacillus mallei.annealing experiments on membrane filters were carried out with deoxyribonucleic acids (dna) from selected strains of the nomen-species of pseudomonas, actinobacillus, chromobacterium, and micrococcus, with the use of dna of pseudomonas pseudomallei and actinobacillus mallei as reference materials. under the usual conditions employed in these experiments, the results were not quantitatively reproducible. incorporation of dimethylsulfoxide (dmso) into the incubation medium greatly increased diffe ...19705438051
[precipitating and agglutinating antigens of pseudomonas pseudomallei (whitmore's bacillus). ii. demonstration of precitating antigens common to yersinia pestis and pseudomonas pseudomallei]. 19704995342
pseudomonas pseudomallei in a case of chronic melioidosis. 19705471230
laboratory evaluation of rifampin and other antimicrobial agents against selected strains of pseudomonas pseudomallei. 19705521374
[transaminases and virulence. i. pseudomonas pseudomallei variants with different virulence]. 19705526115
[precipitating and agglutinating antigens of pseudomonas pseudomallei (whitmore's b.). i. thermostable and thermolabile complexes. serological typing]. 19704989883
melioidosis in imported non-human primates.in 1969, five cases of melioidosis in three separate outbreaks were diagnosed in nonhuman primates in the united states. in the first outbreak, two stump-tailed macaque monkeys (macaca arctoides) developed signs of the disease approximately 6 months after purchase. a third animal, a chimpanzee (pan troglodytes), probably acquired its infection from one of these monkeys. two other unrelated cases involving a pig-tailed monkey (macaca nemestrina) and a rhesus monkey (macaca mulatta) were diagnosed ...197016512115
identification of pseudomonas pseudomallei. 19714933030
growth of pseudomonas pseudomallei & ps. aeruginosa on petroleum fractions. 19714999149
pseudomonas pseudomallei in the surface water of singapore. 19715094428
focal encephalitis due to pseudomonas pseudomallei. 19715107344
in vitro susceptibility of strains of pseudomonas pseudomallei to rifampin.reported high activity of rifampin for pseudomonas pseudomallei could not be verified by extensive in vitro tests conducted with 31 recently isolated strains. minimal inhibitory concentrations of rifampin were 25 mug/ml for three strains and greater than 25 mug/ml for 28 strains. rifampin had relatively poor in vitro activity when compared with tetracycline drugs and chloramphenicol antibiotics now commonly used for treating melioidosis.19715111301
susceptibility in vitro and in vivo of pseudomonas pseudomallei to rifampin and tetracyclines.tests were performed on 64 strains of pseudomonas pseudomallei to compare rifampin, various tetracyclines, and other antibiotics for inhibitory activity in vitro. rifampin minimum inhibitory concentration (mic) values generally fell between 25 to 50 mug/ml. for deoxycycline, methacycline, tetracycline, and minocycline, mic means ranged from 1.3 to 2.7 mug/ml. delayed treatment tests in subacute mouse infections revealed a better rifampin activity than was expected from its weak activity in vitro ...19715111303
cross immunity between mycobacterial and pseudomonas pseudomallei infections in mice. 19714927632
effect of gentamicin on pseudomonas pseudomallei. 19715126250
the sensitivity of pseudomonas pseudomallei to trimethoprim and sulphamethoxazole in vitro.twelve out of 14 strains of pseudomonas pseudomallei were inhibited in vitro by a combination of trimethoprim 1 mug per ml and sulphamethoxazole 20 mug per ml or by lower concentrations. of the remaining strains, one was marginally more resistant and one was distinctly so. in tests utilizing two of the sensitive strains, inhibitory concentrations of the individual drugs exerted a bactericidal effect when combined.19715139985
variable ammonia production among smooth and rough strains of pseudomonas pseudomallei: resemblance to bacteriocin production.the colonial morphology of some strains of pseudomonas pseudomallei was correlated with certain biochemical and physiological traits. after 3 days of growth on wahba or heart infusion agars, smooth-colony strains generated toxic amounts of ammonia. under the same conditions, the rough strains simultaneously produced oxalic acid which decreased the inhibitory concentration of ammonia. the ammonia-ammonium concentrations in smooth cultures exhibited certain bacteriocin-like characteristics. an unu ...19724562401
a serologic survey of military personnel and dogs in thailand and south vietnam for antibodies to arboviruses, rickettsia tsutsugamushi, and pseudomonas pseudomallei. 19724627553
identification of pseudomonas pseudomallei. 19724552650
melioidoses, pseudomonas pseudomallei and the clinical laboratory. 19724556761
[melioidosis and its causative agent: pseudomonas pseudomallei]. 19734703906
bactericidal synergism of novobiocin and tetracycline against pseudomonas pseudomallei. 19734726333
antibiotic susceptibility of pseudomonas pseudomallei.the in vitro activity of various antibiotics against pseudomonas pseudomallei was studied. the tetracyclines were the most active, followed by gentamicin, kanamycin, novobiocin, chloramphenicol, rifampin, cycloserine, erythromycin, and ampicillin.19734790939
pseudomonas pseudomallei (malleomyces pseudomallei) orchitis in a boar. 19744839140
inhibition of pseudomonas pseudomallei by carbenicillin, in vitro. 19744418167
morphological and cytological effects of carbenicillin on pseudomonas pseudomallei. 19744371050
pseudomonas pseudomallei: 1. infection in thailand. 19744499415
pulmonary melioidosis. observations in thirty-nine cases.during the 6-year period from 1965 through 1970, 39 patients with pulmonary melioidosis were treated at fitzsimons army medical center. although this is a disease with a well-defined endemic area that does not include the united states, cases will no doubt continue to be seen in this country. these cases may result from acute infection in the endemic area, with subsequent travel to this country, or from delayed reactivation of a latent infection acquired months or years earlier. given the potent ...19751163890
differentiation between pseudomonas cepacia and pseudomonas pseudomallei in clinical bacteriology.if only conventional laboratory tests are used, the widely occurring species pseudomonas cepacia may, due to its variability, sometimes be difficult to differentiate from the dangerous pathogen pseudomonas pseudomallei. in a comparative study using fresh isolates it is shown that animal inoculation seems to be a useful additional method in the differentiation. also the determination of the ability to utilize selected carbon sources such as starch, hydroxybenzoate and uracil is helpful in reachin ...19751155112
surveillance of some infectious diseases among aircrew personnel in southeast asia.a 2-year analysis of specimens among aircrew personnel in southeast asia is reported. stool specimens were examined for intestinal parasites and enteric bacteria, blood smears for blood parasites, and sera tested for transaminases (sgot) and antibodies to entamoeba histolytica, toxoplasma gondii, chikungunya and japanese encephalitis viruses, rickettsia tsutsugamushi, leptospira sp. and pseudomonas pseudomallei. one to four specimens each were obtained from 537 adult males and 20 females. there ...19751100040
bovine melioidosis in south-eastern queensland.acute fatal infection with pseudomonas pseudomallei caused pneumonia, placentitis and endometritis in a pregnant cow. pneumonia was also present in the foetal lung. mononuclear cell response with extensive karyorrhexis occurred in maternal and foetal lung and the same cellular pathology, but with diffuse distribution, was responsible for plaques on the endometrium. a more chronic disease with encapsulated caseous lesions in the lung, together with arthritis, occurred in a bull on the same proper ...19751191141
[demonstration of pseudomonas pseudomallei (whitmore's bacillus) in the mud of iranian ricefields (author's transl)].whitmore bacillus had killed a horse and a mule in a herd bred for serum production in 1970 (baharsefat and amjadi). out of 157 soil samples from rice fields in northern iran it was possible to isolate 19 times pseudomonas pseudomallei (types i and ii) possessing a very high pathogenicity for animals. attempts at an evaluation of the human incidence of the disease.19751243750
induction of microbial variants of pseudomonas pseudomallei in cultured rabbit alveolar macrophages.cultured alveolar and peritoneal macrophages obtained from normal and immunized rabbits were used to induce wall-defective microbial variants of pseudomonas pseudomallei. variants were iduced only by normal alveolar macrophages. the variants reverted to typical pseudomonas forms either spontaneously or upon transfer into broth or agar.19751220870
human-to-human transmission of pseudomonas pseudomallei.melioidosis, the clinical manifestation of infection with pseudomonas pseudomallei, has occurred infrequently in american citizens; almost all reported cases have been in vietnam veterans, usually associated with respiratory disease. a vietnam veteran from mississippi developed chronic prostatitis, with no other clinical manifestations, during service in vietnam, and p. pseudomallei was isolated from prostatic secretions 2 years after his return to the united states. the patient had had sexual c ...19751174405
pseudomonas pseudomallei: ii. laboratory and experimental studies in animals.the cultural, biochemical characteristics and antibiotic sensitivity of strains of pseudomonas pseudomallei isolated from four cases of melioidosis admitted to ramathibodi hospital are described. the organisms were gram-negative bacilli often with bipolar staining. the colonies were wrinkled when incubated for long periods. the characteristic non-specific uptake of dye from media into the colonies and their musty or earthy odour rendered them easily distinguishable from other organisms. all stra ...197549930
a retrospective serological suvey of royal marines previously exposed to pseudomonas pseudomallei in south east asia.following the suggestion that it was possible that cases of melioidosis amongst those who had been exposed abroad in the past, might be escaping notice, 487 royal marines were examined by indirect haemagglutination studies. four hundred and eleven of these subjects had served for variable times in areas where melioidosis has been known to occur in indonesia and malaya, between 1960 and 1974, occupied in activities in the jungle and paddy fields during which exposure to the disease was to be expe ...19761006764
melioidosis antibodies in commonwealth soldiers.titres of melioidosis haemagglutinating antibodies of 1/40 or more were found in 18 of 905 british, australian, and new zealand soldiers serving in west malaysia. previous mild unsuspected melioidosis seemed to be responsible for these positive titres, which were more common in men exposed to surface water at work and during recreation. this accords with the current view that soil and surface water is the normal habitat of pseudomonas pseudomallei, the causal organism. pyrexia of unknown origin ...197654528
[the in vitro sensitivity of 24 strains of pseudomonas pseudomallei to antibiotics (author's transl)]. 19761021818
[pseudomonas pseudomallei infections: clinical and bacteriologic significance (author's transl)]. 19761021817
terminal exacerbation of chronic melioidosis in new south wales.a fatal case of melioidosis, thought to be the third recorded from new south wales, is presented. infection probably occurred in queensland. the patients presented with a subcutaneous abscess complicated by pyaemia, extensive lung involvement and septicaemic shock. the diagnosis was bacteriologically confirmed shortly before death, by isolation of pseudomonas pseudomallei from blood, pus swabs and tracheal aspirates. there is a need for greater awareness of this disease in persons who have resid ...1976994967
interaction between pseudomonas pseudomallei and cultured rabbit peritoneal macrophages.the interaction between two strains of pseudomonas pseudomallei of different virulence with normal and immune rabbit peritoneal macrophages was compared in vitro. phagocytic activity of macrophages and bacterial survival within macrophages were dependent upon the virulence of the bacterial strain and the immune status of the macrophages. virulent bacteria were more resistant than the less virulent strain to phagocytosis and destruction. immune macrophages were more phagocytic and bactericidal th ...1976987839
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