antimalarial activity of methanolic leaf extract of piper betle l.the need for new compounds active against malaria parasites is made more urgent by the rapid spread of drug-resistance to available antimalarial drugs. the crude methanol extract of piper betle leaves (50-400 mg/kg) was investigated for its antimalarial activity against plasmodium berghei (nk65) during early and established infections. the phytochemical and antioxidant potentials of the crude extract were evaluated to elucidate the possibilities of its antimalarial effects. the safety of the ext ...201021189459
Broad spectrum antidermatophytic drug for the control of tinea infection in human beings.During antifungal evaluation of various plant extracts, free and bound flavonoids of Piper betle were found to be most effective as an antidermatophytic against human pathogenic dermatophytes Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum gypseum and Candida albicans. Dermatophytic fungi cause both superficial and internal mycoses. These mycoses, although normally not lethal, are unpleasant and difficult to cure and cause considerable financial losses. Earlier workers prove that a ...201121929713
availability and characteristics of betel products in the u.s.betel use involves oral placement of shards of areca nut (areca catechu palm seed containing the cholinergic agonist arecoline) wrapped with slaked lime in a betel leaf (piper betle plant) or various chopped or powdered products containing areca nut and/or parts of the betel plant. additives to this mixture include catechu (areca palm extract), spices/ sweeteners (e.g., saccharin, cloves), and/or tobacco. betel use is most common in asia and east india; however, little is known about the availab ...200819004423
piper betle-mediated synthesis, characterization, antibacterial and rat splenocyte cytotoxic effects of copper oxide nanoparticles.the study reports a simple, inexpensive, and eco-friendly synthesis of copper oxide nanoparticles (cuonps) using piper betle leaf extract. formation of cuonps was confirmed by uv-visible spectroscopy at 280 nm. transmission electron microscopy (tem) images showed that the cuonps were spherical, with an average size of 50-100 nm. the scanning electron microscopy (sem)-energy dispersive spectroscopy (eds) peak was observed approximately at 1 and 8 kev. the x-ray diffraction (xrd) studies indicated ...201626148178
effect of piper betle and brucea javanica on the differential expression of hyphal wall protein (hwp1) in non-candida albicans candida (ncac) species.the study aimed to identify the hwp1 gene in non-candida albicans candida species and the differential expression of hwp1 following treatment with piper betle and brucea javanica aqueous extracts. all candidal suspensions were standardized to 1 × 10(6) cells/ml. the suspension was incubated overnight at 37 °c (c. parapsilosis, 35°c). candidal cells were treated with each respective extract at 1, 3, and 6 mg/ml for 24 h. the total rna was extracted and reverse transcription-polymerase chain react ...201323853657
the gastric ulcer-healing action of allylpyrocatechol is mediated by modulation of arginase metabolism and shift of cytokine balance.the role of the ariginine-metabolism in the healing action of the piper betle phenol, allylpyrocatechol (apc) and omeprazole against indomethacin-induced stomach ulceration in mouse was investigated. indomethacin (18 mg/kg) was found to induce maximum stomach ulceration in swiss albino mice on the 3rd day of its administration, which was associated with reduced arginase activity (21.6%, p<0.05), endothelial nitric oxide synthase (enos) expression (72%, p<0.001), and il-4 and tgf-beta levels, alo ...200919409889
growth inhibitory response and ultrastructural modification of oral-associated candidal reference strains (atcc) by piper betle l. extract.candida species have been associated with the emergence of strains resistant to selected antifungal agents. plant products have been used traditionally as alternative medicine to ease mucosal fungal infections. this study aimed to investigate the effects of piper betle extract on the growth profile and the ultrastructure of commonly isolated oral candidal cells. the major component of p. betle was identified using liquid chromatography-mass spectrophotometry (lc-ms/ms). seven atcc control strain ...201424406634
insights into the mechanism of piper betle leaf-induced contact leukomelanosis using c57bl/6 mice as the animal model and tyrosinase assays.background/objectives:ôçé steamed piper betle leaves (pbl) were once used by many taiwanese women to treat pigment disorders on the face. most women claimed a quick, favourable response at first, only to be overcome with facial leukomelanosis later. methods:ôçé c57bl/6 mice were randomly assigned to different groups to study if pbl could cause the following effects: contact dermatitis, leukomelanosis, or hair bleaching. intracellular melanin content was measured by tyrosinase assays. results:ôçé ...201121834811
safrole-modulated immune response is mediated through enhancing the cd11b surface marker and stimulating the phagocytosis by macrophages in balb/c mice.safrole, a component of piper betle inflorescence, is a documented rodent hepatocarcinogen and inhibits bactericidal activity and the release of superoxide anion (o(2-)) by polymorphonuclear leukocytes (pmns). in the present study, we investigated the effects of safrole on immune responses, including natural killer (nk) cell cytotoxicity, phagocytic activity and population distribution of leukocytes from normal balb/c mice. the cells population (cell surface markers) and phagocytosis by macropha ...201222531970
modulation of ionizing radiation induced oxidative imbalance by semi-fractionated extract of piper betle: an in vitro and in vivo assessment.the study was planned to evaluate modulatory effect of aqueous extract of piper betle leaf (pbl) on ionizing radiation mediated oxidative stress leading to normal tissues damage during radiotherapy and other radiation exposures. the total polyphenols and flavonoids known as free radical scavenger (chelators) were measured in the extract. to ascertain antioxidant potential of pbl extract we studied free radical scavenging, metal chelation, reducing power, lipid peroxidation inhibition and ferric ...201020716927
icb3e induces inos expression by ros-dependent jnk and erk activation for apoptosis of leukemic cells.the role of c-jun n terminal kinase (jnk) has been well documented in various cellular stresses where it leads to cell death. similarly, extracellular signal-regulated kinase (erk) which was identified as a signalling molecule for survival pathway has been shown recently to be involved in apoptosis also. recently we reported that icb3e, a synthetic analogue of piper betle leaf-derived apoptosis-inducing agent hydroxychavicol (hch), possesses anti-chronic myeloid leukemia (cml) acitivity in vitro ...201222252531
antitumor activity of npb001-05, an orally active inhibitor of bcr-abl tyrosine kinase.scientists are constantly searching for phytochemical compounds with anti-cancer activity. in this study, activity of plant extract npb001-05 from piper betle was tested on human chronic myelogenous leukemia (cml) xenograft models. npb001-05 was active when dosed orally (500 mg/kg) once or twice a day in xenograft tumor models. npb001-05 showed activity to t315i tumor xenograft, where imatinib failed to show antitumor activity. npb001-05 showed no relevant toxicity in animal models during 2 week ...201121622141
killing of staphylococcus aureus by allylpyrocatechol is potentiated by induction of intracellular oxidative stress and inhibition of catalase activity.this study investigated the effects of allylpyrocatechol (apc), the major component in ethanolic extract of piper betle, on key oxidative stress resistance enzymes important for the survival of staphylococcus aureus, a major pathogen in the human host.201627854197
allylpyrocatechol attenuates collagen-induced arthritis via attenuation of oxidative stress secondary to modulation of the mapk, jak/stat, and nrf2/ho-1 pathways.rheumatoid arthritis (ra), an inflammatory autoimmune disorder, is characterized by synovial hyperplasia and bony destruction. the pathogenesis of ra includes redox dysregulation, concomitant with increased levels of proinflammatory mediators. as the ability of allylpyrocatechol (apc), a phytoconstituent of piper betle leaves, to alleviate oxidative stress has been demonstrated in patients with ra, its antiarthritic activity was evaluated in an animal model of arthritis, and the underlying mecha ...201727856937
piper betle and its bioactive metabolite phytol mitigates quorum sensing mediated virulence factors and biofilm of nosocomial pathogen serratia marcescens in vitro.piper betle, a tropical creeper plant belongs to the family piperaceae. the leaves of this plant have been well known for their therapeutic, religious and ceremonial value in south and southeast asia. it has also been reported to possess several biological activities including antimicrobial, antioxidant, antinociceptive, antidiabetic, insecticidal and gastroprotective activities and used as a common ingredient in indigenous medicines. in indian system of ayurvedic medicine, p. betle has been wel ...201627721053
antioxidant and cytoprotective activities of piper betle, areca catechu, uncaria gambir and betel quid with and without calcium hydroxide.betel quid chewing is a popular habit in southeast asia. it is believed that chewing betel quid could reduce stress, strengthen teeth and maintain oral hygiene. the aim of this study was to investigate the antioxidant and cytoprotective activities of each of the ingredients of betel quid and compared with betel quid itself (with and without calcium hydroxide). the correlation of their cytoprotective and antioxidant activities with phenolic content was also determined.201324330738
inhibitory effect of piper betle linn. leaf extract on protein glycation--quantification and characterization of the antiglycation components.piper betle linn. is a pan-asiatic plant having several beneficial properties. protein glycation and advanced glycation end products (ages) formation are associated with different pathophysiological conditions, including diabetes mellitus. our study aims to find the effect of methanolic extract of p. betle leaves on in vitro protein glycation in bovine serum albumin (bsa)-glucose model. the extract inhibits glucose-induced glycation, thiol group modification and carbonyl formation in bsa in dose ...201324772978
total phenolic compounds, flavonoids, and radical scavenging activity of 21 selected tropical radical scavenging activity of 21 tropical plant extracts was evaluated using 1,1-diphenyl-2-picrylhydrazyl assay (dpph). total phenolic compounds and flavonoids were determined using folin-ciocalteu and hplc, respectively. results of the study revealed that all the plants tested exhibited excellent antioxidant activity with ic(50) in the range of 21.3 to 89.6 microg/ml. the most potent activity was demonstrated by cosmos caudatus (21.3 microg/ml) and piper betle (23.0 microg/ml) that are n ...201420492146
pediculicidal effect of herbal shampoo against pediculus humanus capitis in vitro.human head lice infestation is an important public health problem in thailand. lice resistance is increasing, chemical pediculicides have lost their efficacy and thus alternative products such as herbal shampoos have been proposed to treat lice infestation. the present study investigated the efficacy of twenty nine herbal shampoos based on zinbiberaceae plants, piperaceae plants and native plants against human head lice and compared them with malathion shampoo (a-lices shampoo®: 1% w/v malathion ...201323959497
psidium guajava and piper betle leaf extracts prolong vase life of cut carnation (dianthus caryophyllus) flowers.the effect of leaf extracts of psidium guajava and piper betle on prolonging vase life of cut carnation flowers was studied. "carola" and "pallas orange" carnation flowers, at bud stage, were pulsed 24 hours with a floral preservative. then, flowers were placed in a vase solution containing sprite and a "germicide" (leaf extracts of p. guajava and p. betle, 8-hqc, or a copper coin). flowers treated with 8-hqc, copper coin, and leaf extracts had longer vase life, larger flower diameter, and highe ...201222619568
hydroxychavicol, a piper betle leaf component, induces apoptosis of cml cells through mitochondrial reactive oxygen species-dependent jnk and endothelial nitric oxide synthase activation and overrides imatinib resistance.alcoholic extract of piperbetle (piper betle l.) leaves was recently found to induce apoptosis of cml cells expressing wild type and mutated bcr-abl with imatinib resistance phenotype. hydroxychavicol (hch), a constituent of the alcoholic extract of piper betle leaves, was evaluated for anti-cml activity. here, we report that hch and its analogues induce killing of primary cells in cml patients and leukemic cell lines expressing wild type and mutated bcr-abl, including the t315i mutation, with m ...201121943109
effect of aqueous extracts of mentha arvensis (mint) and piper betle (betel) on growth and citrinin production from toxigenic penicillium citrinum.due to growing concern of consumers about chemical residues in food products, the demand for safe and natural food is increasing greatly. the use of natural additives such as spices and herbal oil as seasoning agents for their antimicrobial activity has been extensively investigated. this paper discusses the efficacy of the aqueous extract of mint (mentha arvensis) and betel (piper betle) on the mycelial growth and citrinin production of penicillium citrinum. the present investigation revealed t ...201526028728
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