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effects of thai piperaceae plant extracts on neospora caninum infection.neosporosis has a worldwide distribution and causes economic losses in farming, particularly by increasing the risk of abortion in cattle. this study investigated the effects of thai piperaceae (piper betle, p. nigrum, and p. sarmentosum) extracts on neospora caninum infections in vitro and in vivo. in an in vitro parasite growth assay based on the green fluorescent protein (gfp) signal, p. betle was the most effective extract at inhibiting parasite growth in human foreskin fibroblast cells (ic5 ...201728137670
ethnobiological treatments of neurological conditions in the chota nagpur plateau, india.world health organization (who) has recognized the contribution of traditional medicine in the primary health care system. who also considers neurological disorders as one of the prime concern to the public health. inadequate and inaccessible health facilities in the rural and underprivileged areas have forced the various tribal and non-tribal communities to use ethno-phyto and ethno-zoo therapeutics against different ailments. chota nagpur plateau, india is one of the richest in india in terms ...201728017696
in vitro anticancer activity of ethanolic extracts of piper nigrum against colorectal carcinoma cell lines.piper nigrum (pn) is well known for its cytotoxic and pharmacological benefits. however, there is minimal documented evidence about its cytotoxic efficacy against colorectal carcinoma. we therefore sought to procure a precisely quantitative and qualitative result, pertaining the efficacy of an ethanolic extract of pn (eepn) against colorectal carcinoma.201728251112
endophytic phomopsis sp. colonization in oryza sativa was found to result in plant growth promotion and piperine production.endophytic fungi have been reported to have the acquired ability to synthesize host plant specific medicinal natural products. many fungi with such properties have been characterized and optimized for the conditions which favor maximal production of desired products. however, the inherent plant colonization property of promising endophytic fungi is least studied. exploiting the transgenome functioning of these fungi have immense applications to add beneficial features to non-host plants. in the ...201728224643
the dynamic microbiota profile during pepper (piper nigrum l.) peeling by solid-state fermentation.white pepper (piper nigrum l.), a well-known spice, is the main pepper processing product in hainan province, china. the solid-state method of fermentation can peel pepper in a highly efficient manner and yield high-quality white pepper. in the present study, we used next-generation sequencing to reveal the dynamic changes in the microbiota during pepper peeling by solid-state fermentation. the results suggested that the inoculated aspergillus niger was dominant throughout the fermentation stage ...201728378160
a biodegradable device for the controlled release of piper nigrum (piperaceae) standardized extract to control aedes aegypti (diptera, culicidae) larvae.the significant increase in dengue, zika, and chikungunya and the resistance of the aedes aegypti mosquito to major insecticides emphasize the importance of studying alternatives to control this vector. the aim of this study was to develop a controlled-release device containing piper nigrum extract and to study its larvicidal activity against aedes aegypti.201728001214
olfactory loss management in view of avicenna: focus on neuroprotective plants.loss of olfaction can cause noticeable reduction in general quality of life. only a small portion of patients with olfactory loss respond to current medications. thus, development of novel therapeutic strategies seems to be necessary. looking into traditional medical knowledge can be of great value in addressing useful remedies. traditional persian medicine (tpm) has been practiced in persia for more than 2000 years. avicenna is the most eminent persian physician.201728302020
the srnaome mining revealed existence of unique signature small rnas derived from 5.8srrna from piper nigrum and other plant lineages.small rnas derived from ribosomal rnas (srrnas) are rarely explored in the high-throughput data of plant systems. here, we analyzed srrnas from the deep-sequenced small rna libraries of piper nigrum, a unique magnoliid plant. the 5' end of the putative long form of 5.8s rrna (5.8slrrna) was identified as the site for biogenesis of highly abundant srrnas that are unique among the piperaceae family of plants. a subsequent comparative analysis of the ninety-seven srnaomes of diverse plants successf ...201728145468
in vitro assessment of the acaricidal activity of piper longum, piper nigrum, and zingiber officinale extracts against hyalomma anatolicum ticks.ticks and tick-borne diseases are a major constraint for the sustainable cattle industry in the tropical and subtropical regions including the indian subcontinent. the development of resistance to most of the commonly used acaricides leads to an attempt to screen plant extracts and their combinations for their possible acaricidal activity to develop an eco-friendly tick control alternative. an alcoholic and various aqueous extracts of piper longum, piper nigrum and zingiber officinale and their ...201728251408
review of scientific evidence of medicinal convoy plants in traditional persian medicine.one concept used in traditional persian medicine (tpm) for multidrug therapy is that of the convoy drug (mobadregh). according to tpm texts, convoy drugs are substances (or drugs), which facilitate the access of drugs or foods to the whole body or to specific organs. this study reviewed some convoy drugs presented in tpm, their biological effects, and their probable interactions with main drugs, considering the increased absorption through inhibition of p-glycoprotein (p-gp) efflux function, bio ...201727041871
recent progress for the utilization of curcuma longa, piper nigrum and phoenix dactylifera seeds against type 2 diabetes.diabetes mellitus is an important human disease afflicting many from various walks of life in different countries. even though modern medicines contribute a variety of effective treatment options, they can have several unfavourable effects. the intention of this review is to organize and discuss various studies that have been previously conducted on the effectiveness of these herbal plants in diabetes.201627399905
in vitro blood-brain barrier permeability predictions for gabaa receptor modulating piperine analogs.the alkaloid piperine from black pepper (piper nigrum l.) and several synthetic piperine analogs were recently identified as positive allosteric modulators of γ-aminobutyric acid type a (gabaa) receptors. in order to reach their target sites of action, these compounds need to enter the brain by crossing the blood-brain barrier (bbb). we here evaluated piperine and five selected analogs (sct-66, sct-64, sct-29, lau397, and lau399) regarding their bbb permeability. data were obtained in three in v ...201627018328
mycotoxin production and predictive modelling kinetics on the growth of aspergillus flavus and aspergillus parasiticus isolates in whole black peppercorns (piper nigrum l).the growth and mycotoxin production of three aspergillus flavus isolates and an aspergillus parasiticus isolate were studied in whole black peppercorns (piper nigrum l.) using a full factorial design with seven water activity (aw) (0.826-0.984) levels and three temperatures (22, 30 and 37°c). growth rates and lag phases were estimated using linear regression. diverse secondary models were assessed for their ability to describe the radial growth rate as a function of individual and combined effec ...201627088871
integrated plant nutrient system - with special emphasis on mineral nutriton and biofertilizers for black pepper and cardamom - a review.integrated plant nutrition system (ipns) as a concept and farm management strategy embraces and transcends from single season crop fertilization efforts to planning and management of plant nutrients in crop rotations and farming systems on a long-term basis for enhanced productivity, profitability and sustainability. it is estimated that about two-thirds of the required increase in crop production in developing countries will have to come from yield increases from lands already under cultivation ...201625834919
spices for prevention and treatment of cancers.spices have been widely used as food flavorings and folk medicines for thousands of years. numerous studies have documented the antioxidant, anti-inflammatory and immunomodulatory effects of spices, which might be related to prevention and treatment of several cancers, including lung, liver, breast, stomach, colorectum, cervix, and prostate cancers. several spices are potential sources for prevention and treatment of cancers, such as curcuma longa (tumeric), nigella sativa (black cumin), zingibe ...201627529277
influence of temperature on symptom expression, detection of host factors in virus infected piper nigrum l.expression of symptoms in black pepper plants (piper nigrum) infected with piper yellow mottle virus (pymov) vary depending on the season, being high during summer months. here, we explored the influence of temperature on symptom expression in pymov infected p. nigrum. our controlled environment study revealed increase in virus titer, total proteins, iaa and reducing sugars when exposed to temperature stress. there was change in the 2-d separated protein before and after exposure. the 2-d proteo ...201627319055
transcriptome- assisted label-free quantitative proteomics analysis reveals novel insights into piper nigrum-phytophthora capsici phytopathosystem.black pepper (piper nigrum l.), a tropical spice crop of global acclaim, is susceptible to phytophthora capsici, an oomycete pathogen which causes the highly destructive foot rot disease. a systematic understanding of this phytopathosystem has not been possible owing to lack of genome or proteome information. in this study, we explain an integrated transcriptome-assisted label-free quantitative proteomics pipeline to study the basal immune components of black pepper when challenged with p. capsi ...201627379110
the larvicidal effects of black pepper (piper nigrum l.) and piperine against insecticide resistant and susceptible strains of anopheles malaria vector mosquitoes.insecticide resistance carries the potential to undermine the efficacy of insecticide based malaria vector control strategies. therefore, there is an urgent need for new insecticidal compounds. black pepper (dried fruit from the vine, piper nigrum), used as a food additive and spice, and its principal alkaloid piperine, have previously been shown to have larvicidal properties. the aim of this study was to investigate the larvicidal effects of ground black pepper and piperine against third and fo ...201627117913
piperine suppresses pyroptosis and interleukin-1β release upon atp triggering and bacterial infection.piperine is a phytochemical present in black pepper (piper nigrum linn) and other related herbs, possessing a wide array of pharmacological activities including anti-inflammatory effects. previously, we demonstrated that piperine has therapeutic effects on bacterial sepsis in mice, but the underlying mechanism has not been fully elucidated. in this study, we aimed to investigate the influences of piperine on pyroptosis in murine macrophages. the results showed that piperine dose-dependently inhi ...201627812336
investigation of scavenging activities and distribution of paramagnetic species in zanthoxylum limonella seeds.we investigated the scavenging activities of methanol-extracted oil and the distribution of paramagnetic species in zanthoxylum limonella (zl) seeds using noninvasive 9 ghz electron paramagnetic resonance (epr) imaging and continuous wave epr. epr detected three different stable paramagnetic species that were assigned to stable organic radicals, mn(2+), and other paramagnetic metal complexes. two-dimensional epr imaging showed that the stable paramagnetic species were located in the pigmented se ...201627817252
influence of combinations of fenugreek, garlic, and black pepper powder on production traits of the broilers.to study the effects of combinations of fenugreek (trigonella foenum-graecum l.), garlic (allium sativum), and black pepper (piper nigrum) powder supplementation on production traits of broiler chickens.201627284222
de novo transcriptome sequencing of black pepper (piper nigrum l.) and an analysis of genes involved in phenylpropanoid metabolism in response to phytophthora capsici.piper nigrum l., or "black pepper", is an economically important spice crop in tropical regions. black pepper production is markedly affected by foot rot disease caused by phytophthora capsici, and genetic improvement of black pepper is essential for combating foot rot diseases. however, little is known about the mechanism of anti- p. capsici in black pepper. the molecular mechanisms underlying foot rot susceptibility were studied by comparing transcriptome analysis between resistant (piper flav ...201627769171
activity of medicinal plant extracts on multiplication of mycobacterium tuberculosis under reduced oxygen conditions using intracellular and axenic assays.aim. test the activity of selected medicinal plant extracts on multiplication of mycobacterium tuberculosis under reduced oxygen concentration which represents nonreplicating conditions. material and methods. acetone, ethanol and aqueous extracts of the plants acorus calamus l. (rhizome), ocimum sanctum l. (leaf), piper nigrum l. (seed), and pueraria tuberosa dc. (tuber) were tested on mycobacterium tuberculosis h37rv intracellularly using an epithelial cell (a549) infection model. the extracts ...201626941797
inhibition of quorum-sensing-mediated biofilm formation in cronobacter sakazakii strains.the present study investigated plant extracts for their anti-quorum-sensing (qs) potential to inhibit the biofilm formation in cronobacter sakazakii strains. the bioassay based on loss of pigment production by chromobacterium violaceum 026 and agrobacterium tumefaciens ntl4(pzlr4) was used for initial screening of the extracts. further, the effect of extracts on the inhibition of qs-mediated biofilm in c. sakazakii isolates was evaluated using standard crystal violet assay. the effect on biofilm ...201627460095
interplay of genes in plant-pathogen interactions: in planta expression and docking studies of a beta 1,3 glucanase gene from piper colubrinum and a glucanase inhibitor gene from phytophthora capsici.oomycete pathogen, phytophthora capsici is devastating for black pepper (piper nigrum l.) and causes foot rot disease at all stages of plant growth. phytophthora secretes a glucanase inhibitor protein (gip), which is capable of inhibiting defence proteins like endoglucanases. in this particular study quantitative pcr analysis, molecular docking studies and analysis of sequences of glucanase inhibitor protein and beta-1,3 glucanse genes were done mainly depending on the data derived from phytopht ...201627924129
corrigendum: leishmanicidal activity of piper nigrum bioactive fractions is interceded via apoptosis in vitro and substantiated by th1 immunostimulatory potential in vivo.[this corrects the article on p. 1368 in vol. 6, pmid: 26696979.].201627379073
effect of different in vitro culture extracts of black pepper (piper nigrum l.) on toxic metabolites-producing strains.in the present study, the effect of different in vitro cultures (callus, in vitro shoots) and commercially available peppercorn extract was investigated for its activity against toxic metabolite-producing strains (escherichia coli, pseudomonas aeroginosa, salmonella typhi, bacillus subtilis, bacillus cereus, staphylococcus aureus, and candida albicans). these in vitro cultures were extracted with ethanol, hexane, and chloroform, and the antipathogenic activity was determined by well-diffusion me ...201624193053
transfer rna derived small rnas targeting defense responsive genes are induced during phytophthora capsici infection in black pepper (piper nigrum l.).small rnas derived from transfer rnas were recently assigned as potential gene regulatory candidates for various stress responses in eukaryotes. in this study, we report on the cloning and identification of trna derived small rnas from black pepper plants in response to the infection of the quick wilt pathogen, phytophthora capsici. 5'trfs cloned from black pepper were validated as highly expressed during p. capsici infection. a high-throughput systematic analysis of the small rnaome (srnaome) r ...201627313593
enzyme-assisted supercritical carbon dioxide extraction of black pepper oleoresin for enhanced yield of piperine-rich extract.black pepper (piper nigrum l.), the king of spices is the most popular spice globally and its active ingredient, piperine, is reportedly known for its therapeutic potency. in this work, enzyme-assisted supercritical carbon dioxide (sc-co2) extraction of black pepper oleoresin was investigated using α-amylase (from bacillus licheniformis) for enhanced yield of piperine-rich extract possessing good combination of phytochemical properties. optimization of the extraction parameters (without enzyme), ...201525617183
leishmanicidal activity of piper nigrum bioactive fractions is interceded via apoptosis in vitro and substantiated by th1 immunostimulatory potential in vivo.visceral leishmaniasis (vl) is a life-threatening protozoal infection chiefly impinging the rural and poor population in the tropical and sub-tropical countries. the deadly affliction is rapidly expanding after its association with aids, swiftly defying its status of a neglected disease. despite successful formulation of vaccine against canine leishmaniasis, no licensed vaccine is yet available for human vl, chemotherapy is in appalling state, and the development of new candidate drugs has been pa ...201526696979
down-regulation of osmotin (pr5) gene by virus-induced gene silencing (vigs) leads to susceptibility of resistant piper colubrinum link. to the oomycete pathogen phytophthora capsici leonian.piper colubrinum link., a distant relative of piper nigrum l., is immune to the oomycete pathogen phytophthora capsici leonian that causes 'quick wilt' in cultivated black pepper (p. nigrum). the osmotin, pr5 gene homologue, earlier identified from p. colubrinum, showed significant overexpression in response to pathogen and defense signalling molecules. the present study focuses on the functional validation of p. colubrinum osmotin (pcosm) by virus induced gene silencing (vigs) using tobacco rat ...201526155671
in vitro antibacterial activity of seven indian spices against high level gentamicin resistant strains of enterococci.the aim of the study was to explore the in vitro antibacterial activity of seven ethanolic extracts of spices against high level gentamicin resistant (hlgr) enterococci isolated from human clinical samples.201526322099
toxigenic potentiality of aspergillus flavus and aspergillus parasiticus strains isolated from black pepper assessed by an lc-ms/ms based multi-mycotoxin method.a liquid chromatography triple quadrupole tandem mass spectrometry method was developed and validated to determine mycotoxins, produced by fungal isolates grown on malt extract agar (mea). all twenty metabolites produced by different fungal species were extracted using acetonitrile/1% formic acid. the developed method was applied to assess the toxigenic potentiality of aspergillus flavus (n = 11) and aspergillus parasiticus (n = 6) strains isolated from black peppers (piper nigrum l.) following ...201526338134
could essential oils of green and black pepper be used as food preservatives?black and green pepper essential oils were used in this study in order to determine the chemical composition, in vitro antimicrobial activity against food spoilage microorganisms and in situ oils effect on food microorganism, after incorporation in chicken soup, by suggested methodology for calculation of growth inhibition concentrations (gic50). chemical analysis revealed a total of 34 components. the major constituent of black pepper oil was trans-caryophyllene (30.33 %), followed by limonene ...201526396402
antifertility activity of medicinal plants.the aim of this review was to provide a comprehensive summary of medicinal plants used as antifertility agents in females throughout the world by various tribes and ethnic groups. we undertook an extensive bibliographic review by analyzing classical text books and peer reviewed papers, and further consulting well accepted worldwide scientific databases. we performed central, embase, and pubmed searches using terms such as "antifertility", "anti-implantation", "antiovulation", and "antispermatoge ...201525921562
endophytic bacteria from piper tuberculatum jacq.: isolation, molecular characterization, and in vitro screening for the control of fusarium solani f. sp piperis, the causal agent of root rot disease in black pepper (piper nigrum l.).endophytic bacteria have been found to colonize internal tissues in many different plants, where they can have several beneficial effects, including defense against pathogens. in this study, we aimed to identify endophytic bacteria associated with roots of the tropical piperaceae piper tuberculatum, which is known for its resistance to infection by fusarium solani f. sp piperis, the causal agent of black pepper (piper nigrum) root rot disease in the amazon region. based on 16s rrna gene sequence ...201526214435
the roman and islamic spice trade: new archaeological evidence.tropical spices have long been utilized in traditional medicine and cuisine. new archaeological evidence highlights temporal changes in the nature and scale of the ancient spice trade and in the ancient usage of these plants. furthermore, a study of their 'materiality' highlights that the impact of spices extends beyond their material properties. here the botanical remains of spices recovered from archaeological excavations at a port active in the roman and medieval islamic spice trade are evalu ...201525278182
repellency of plant extracts against the legume flower thrips megalurothrips sjostedti (thysanoptera: thripidae).megalurothrips sjostedti trybom is an important pest of cowpea (vigna unguiculata l.) in africa. to propose an alternative to chemical control, the repellency of 24 plant extracts was evaluated against adult female thrips of m. sjostedti in the laboratory. plant extracts in ethanol were separately applied on a filter paper disk in a still air visual cue olfactometer. the results showed highly significant differences in repellency among extract type, concentration and their interactions. we class ...201526463406
physiological and biochemical effects of botanical extract from piper nigrum linn (piperaceae) against the dengue vector aedes aegypti liston (diptera: culicidae).the leaves of piper nigrum l. (piperaceae) were evaluated for chemical constituents and mosquito larvicidal activity against the larvae of aedes aegypti. gc and gc-ms analyses revealed that the crude extracts contain 16 compounds. thymol (20.77%) and ç-elemene (10.42%) were identified as the major constituents followed by cyclohexene, 4-ethenyl-4-methyl-3-(1-methylethenyl)-1-(1 methylethyl)-, (3r-trans) (7.58%), 4,6-octadienoic acid, 2-acetyl-2-methyl-, ethyl ester (6.98), 2(3h)-furanone, 3,4-bi ...201526277727
aedes aegypti larvicide from the ethanolic extract of piper nigrum black peppercorns.due to unavailability of a vaccine and a specific cure to dengue, the focus nowadays is to develop an effective vector control method against the female aedes aegypti mosquito. this study aims to determine the larvicidal fractions from piper nigrum ethanolic extracts (pnpcme) and to elucidate the identity of the bioactive compounds that comprise these larvicidal fractions. larvicidal assay was performed by subjecting 3rd to 4th a. aegypti instar larvae to pnpcme of p. nigrum. the pnpcme exhibite ...201525118563
rhynchophorus ferrugineus midgut cell line to evaluate insecticidal potency of different plant essential oils.cell cultures can be a potent and strong tool to evaluate the insecticidal efficiency of natural products. plant essential oils have long been used as the fragrance or curative products around the world which means that they are safer to be used in close proximity of humans and mammals. in this study, a midgut cell line, developed from rhynchophorus ferrugineus (rpw-1), was used for screening essential oils from nine different plants. assays revealed that higher cell mortality was observed at 50 ...201525381034
evaluation of in vitro aldose reductase inhibitory potential of alkaloidal fractions of piper nigrum, murraya koenigii, argemone mexicana, and nelumbo nucifera.aldose reductase is primarily involved in development of long-term diabetic complications due to increased polyol pathway activity. the synthetic aldose reductase inhibitors are not very successful clinically. therefore, the natural sources may be exploited for safer and effective aldose reductase inhibitors.201424127538
elucidation of the inhibitory effect of phytochemicals with kir6.2 wild-type and mutant models associated in type-1 diabetes through molecular docking approach.among all serious diseases globally, diabetes (type 1 and type 2) still poses a major challenge to the world population. several target proteins have been identified, and the etiology causing diabetes has been reasonably well studied. but, there is still a gap in deciding on the choice of a drug, especially when the target is mutated. mutations in the kcnj11 gene, encoding the kir6.2 channel, are reported to be associated with congenital hyperinsulinism, having a major impact in causing type 1 d ...201425705171
effects of black pepper (piper nigrum), turmeric powder (curcuma longa) and coriander seeds (coriandrum sativum) and their combinations as feed additives on growth performance, carcass traits, some blood parameters and humoral immune response of broiler chickens.different herbs and spices have been used as feed additives for various purposes in poultry production. this study was conducted to assess the effect of feed supplemented with black pepper (piper nigrum), turmeric powder (curcuma longa), coriander seeds (coriandrum sativum) and their combinations on the performance of broilers. a total of 210 (cobb) one-d-old chicks were divided into seven groups of 30 birds each. the treatments were: a control group received no supplement, 0.5% black pepper (t1 ...201425050023
inactivation of escherichia coli o157:h7 and salmonella typhimurium in black pepper and red pepper by gamma irradiation.this study evaluated the efficacy of gamma irradiation to inactivate foodborne pathogens in black pepper (piper nigrum) and red pepper (dried capsicum annuum). black pepper and red pepper inoculated with escherichia coli o157:h7 and salmonella typhimurium were subjected to gamma irradiation in the range of 0, 1, 2, 3 and 5 kgy, and color change was evaluated after treatment. pathogen populations decreased with increasing treatment doses. a gamma irradiation dose of 5 kgy decreased e. coli o157:h ...201424370971
lc-ms/ms based identification of piperine production by endophytic mycosphaerella sp. pf13 from piper nigrum.piper nigrum is very remarkable for its medicinal properties due to the presence of metabolites like piperine. emerging understanding on the biosynthetic potential of endophytic fungi suggests the possibility to have piperine producing fungi in p. nigrum. in the current study, endophytic fungi isolated from p. nigrum were screened for the presence of piperine by liquid chromatography-tandem mass spectrometry (lc-ms/ms). this resulted in the identification of a mycosphaerella sp. with the ability ...201424691878
efficacy and safety of topical trikatu preparation in, relieving mosquito bite reactions: a randomized controlled trial.trikatu is composed of dried fruits of piper nigrum l and piper retrofractum vahl, and dried rhizomes of zingiber officinale r. although this preparation has been used to relieve pruritis, pain, and inflammation for a long time, there is no clinical evidence to confirm its efficacy and safety. therefore, we performed a double-blind, within person-randomized controlled study of 30 healthy volunteers to determine efficacy and safety of topical trikatu on mosquito bite reactions.201424559814
combined effects of gamma-irradiation and modified atmosphere packaging on quality of some spices.thyme (thymus vidgaris l.), rosemary (rosmarinus officinalis l.), black pepper (piper nigrum l.) and cumin (cuminum cyminum l.) in ground form were packaged in either air or 100% n2 and γ-irradiated at 3 different irradiation levels (7kgy, 12kgy, 17kgy). total viable bacterial count, yeast and mould count, colour, essential oil yield and essential oil composition were determined. microbial load was not detectable after 12kgy irradiation of all samples. irradiation resulted in significant changes ...201424518340
isolation, characterization and identification of pericarp-degrading bacteria for the production of off-odour-free white pepper from fresh berries of piper nigrum l.to isolate, fermentatively evaluate and identify black pepper (piper nigrum l.)-associated bacteria for the microbial decortication of fresh ripened berries and dried black pepper for preparation of off-odour-free white pepper.201424387754
antifungal activity and computational study of constituents from piper divaricatum essential oil against fusarium infection in black pepper.fusarium disease causes considerable losses in the cultivation of piper nigrum, the black pepper used in the culinary world. brazil was the largest producer of black pepper, but in recent years has lost this hegemony, with a significant reduction in its production, due to the ravages produced by the fusarium solani f. sp. piperis, the fungus which causes this disease. scientific research seeks new alternatives for the control and the existence of other piper species in the brazilian amazon, resi ...201425375334
muscodor albus mow12 an endophyte of piper nigrum l. (piperaceae) collected from north east india produces volatile antimicrobials.muscodor albus mow12, an endophytic fungus isolated from piper nigrum in mawlong, meghalaya, india, resembles some cultural and hyphal characteristics of previous isolates of muscodor sp. in addition, it possesses about 99 % similarity in its its rdna with other m. albus isolates and thus is nicely centered within the genetic tree to other muscodor spp. this xylariaceae fungus effectively inhibits and kills certain plant pathogenic fungi by virtue of a mixture of volatile compounds that it produ ...201424426163
properties for sourcing nigerian larvicidal plants.aedes aegypti is the primary vector of chikungunya, yellow and dengue fevers. dengue fever is the major cause of child morbidity and hospitalisation in some asian and african countries, while yellow fever is prevalent in nigeria. the development of resistance to the available insecticides has necessitated the continued search for safer ones from plants. eighteen plant extracts with ethnomedical claims of or demonstrated febrifuge, antimalarial, insecticidal and insect repellent biological activi ...201424950440
piperine production by endophytic fungus colletotrichum gloeosporioides isolated from piper nigrum.many endophytic fungi have been reported with the biosynthetic potential to produce same or similar metabolites present in host plants. the adaptations that might have acquired by these fungi as a result of the long-term association with their host plants can be the possible basis of their biosynthetic potential. the bioactive compounds originated from endophytes are currently explored for their potential applications in pharmaceutical, agriculture and food industries. piper nigrum, a plant of t ...201424268806
inhibitory effect of piperine on helicobacter pylori growth and adhesion to gastric adenocarcinoma cells.piperine is a compound comprising 5-9% of black pepper (piper nigrum), which has a variety of biological roles related to anticancer activities. helicobacter pylori has been classified as a gastric carcinogen, because it causes gastritis and gastric cancer by injecting the virulent toxin caga and translocating vaca. the present study investigated the inhibitory action of piperine on h. pylori growth and adhesion.201425584066
studies on the factors modulating indole-3-acetic acid production in endophytic bacterial isolates from piper nigrum and molecular analysis of ipdc gene.the study mainly aimed quantitative analysis of iaa produced by endophytic bacteria under various conditions including the presence of extract from piper nigrum. analysis of genetic basis of iaa production was also conducted by studying the presence and diversity of the ipdc gene among the selected isolates.201424916921
protective effects of piperine against copper-ascorbate induced toxic injury to goat cardiac mitochondria in vitro.piperine, the main alkaloid of black pepper, piper nigrum linn., is an important indian spice used in traditional food and medicine in india. in the present study, we investigated the antioxidant activities of piperine against copper-ascorbate induced toxic injury to mitochondria obtained from a goat heart, in vitro. incubation of isolated cardiac mitochondria with copper-ascorbate resulted in elevated levels of lipid peroxidation and protein carbonylation of the mitochondrial membrane, a reduce ...201425059674
sequence diversity among badnavirus isolates infecting black pepper and related species in india.the badnavirus, piper yellow mottle virus (pymov) is known to infect black pepper (piper nigrum), betelvine (p. betle) and indian long pepper (p. longum) in india and other parts of the world. occurrence of pymov or other badnaviruses in other species of piper and its variability is not reported so far. we have analysed sequence variability in the conserved putative reverse transcriptase (rt)/ribonuclease h (rnase h) coding region of the virus using specific badnavirus primers from 13 virus isol ...201425674613
piper nigrum leaf and stem assisted green synthesis of silver nanoparticles and evaluation of its antibacterial activity against agricultural plant pathogens.utilization of biological materials in synthesis of nanoparticles is one of the hottest topics in modern nanoscience and nanotechnology. in the present investigation, the silver nanoparticles were synthesized by using the leaf and stem extract of piper nigrum. the synthesized nanoparticle was characterized by uv-vis spectroscopy, x-ray diffraction (xrd), scanning electron microscope (sem), transmission electron microscope (tem), energy dispersive x-ray analysis (edax), and fourier transform infr ...201424558336
design, synthesis and trypanocidal evaluation of novel 1,2,4-triazoles-3-thiones derived from natural piperine.the work reported herein describes the synthesis and the assessment of the trypanocidal activity of thirteen new 1,2,4-triazole-3-thiones obtained from natural piperine, the main constituent of the dry fruits of piper nigrum. it is part of a research program aiming to use abundant and easily available natural products as starting materials for the design and synthesis of new molecules potentially useful as antiparasitic drugs. the variously substituted triazole derivatives were synthesized from ...201323760033
in vitro antibacterial and antibiotic-potentiation activities of four edible plants against multidrug-resistant gram-negative species.the present study was designed to investigate the antibacterial activities of the methanol extracts of four cameroonian edible plants, locally used to treat microbial infections, and their synergistic effects with antibiotics against a panel of twenty nine gram-negative bacteria including multi-drug resistant (mdr) phenotypes expressing active efflux pumps.201323885762
piper nigrum, piper betle and gnetum gnemon--natural food sources with anti-quorum sensing properties.various parts of piper nigrum, piper betle and gnetum gnemon are used as food sources by malaysians. the purpose of this study is to examine the anti-quorum sensing (anti-qs) properties of p. nigrum, p. betle and g. gnemon extracts. the hexane, chloroform and methanol extracts of these plants were assessed in bioassays involving pseudomonas aeruginosa pa01, escherichia coli [psb401], e. coli [psb1075] and chromobacterium violaceum cv026. it was found that the extracts of these three plants have ...201323519352
synergistic larvicidal effect and morphological alterations induced by ethanolic extracts of annona muricata and piper nigrum against the dengue fever vector aedes aegypti.phytopesticide combinations of different botanical sources are seldom reported. annona muricata seed and piper nigrum fruit ethanolic extracts enriched in acetogenins and piperamides, respectively, were synergistically used as larvicides against the dengue fever vector aedes aegypti.201323112098
ethnobotanical survey of malaria prophylactic remedies in odisha, india.to investigate the plants traditionally used for prevention of malaria in cuttack, gajapati and koraput districts of odisha state, eastern india.201323434608
rapid detection of piper yellow mottle virus and cucumber mosaic virus infecting black pepper (piper nigrum) by loop-mediated isothermal amplification (lamp).the loop-mediated isothermal amplification (lamp) assay for piper yellow mottle virus and the reverse transcription (rt) lamp assay for cucumber mosaic virus each consisted of a set of five primers designed against the conserved sequences in the viral genome. both rna and dna isolated from black pepper were used as a template for the assay. the results were assessed visually by checking turbidity, green fluorescence and pellet formation in the reaction tube and also by gel electrophoresis. the a ...201323791964
inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant piper nigrum, for possible use in parkinson's disease.a series of compounds related to piperine and antiepilepsirine was screened in a monoamine oxidase a and b assay. piperine is an alkaloid from the source plant of both black and white pepper grains, piper nigrum. piperine has been shown to have a wide range of activity, including mao inhibitory activity. the z-factor for the screening assay was found to be greater than 0.8 for both assays. notably, the compounds tested were selective towards mao-b, with the most potent compound having an ic(50) ...201223102654
analysis of the blackening of green pepper (piper nigrum linnaeus) berries.this paper investigates polyphenol oxidase (ppo) activity, reduced weight percentage after sun drying, and the changes in colour and appearance of green pepper (piper nigrum linnaeus) berries after blanching and sun drying. the results show that the degree of reduced weight percentage and browning in green pepper berries after blanching for 10 min is greater at 100°c than at 90 and 80°c. moreover, the samples blanched at 100°c for 10 min had the fastest water loss, but the lowest ppo activity. t ...201223411179
antimalarial activities of medicinal plants traditionally used in the villages of dharmapuri regions of south india.an ethnopharmacological investigation of medicinal plants traditionally used to treat diseases associated with fevers in dharmapuri region of south india was undertaken. twenty four plants were identified and evaluated for their in vitro activity against plasmodium falciparum and assessed for cytotoxicity against hela cell line.201222433533
high-throughput sequencing of black pepper root transcriptome.black pepper (piper nigrum l.) is one of the most popular spices in the world. it is used in cooking and the preservation of food and even has medicinal properties. losses in production from disease are a major limitation in the culture of this crop. the major diseases are root rot and foot rot, which are results of root infection by fusarium solani and phytophtora capsici, respectively. understanding the molecular interaction between the pathogens and the host's root region is important for obt ...201222984782
growth and survival of salmonella in ground black pepper (piper nigrum).a four serovar cocktail of salmonella was inoculated into ground black pepper (piper nigrum) at different water activity (aw) levels at a starting level of 4-5 log cfu/g and incubated at 25 and at 35 °c. at 35 °c and aw of 0.9886 ± 0.0006, the generation time in ground black pepper was 31 ± 3 min with a lag time of 4 ± 1 h. growth at 25 °c had a longer lag, but generation time was not statistically different from growth at 35 °c. the aw threshold for growth was determined to be 0.9793 ± 0.0027 a ...201223498196
β-caryophyllene oxide inhibits growth and induces apoptosis through the suppression of pi3k/akt/mtor/s6k1 pathways and ros-mediated mapks activation.both pi3k/akt/mtor/s6k1 and mitogen activated protein kinase (mapk) signaling cascades play an important role in cell proliferation, survival, angiogenesis, and metastasis of tumor cells. in the present report, we investigated the effects of β-caryophyllene oxide (cpo), a sesquiterpene isolated from essential oils of medicinal plants such as guava (psidium guajava), oregano (origanum vulgare l.), cinnamon (cinnamomum spp.) clove (eugenia caryophyllata), and black pepper (piper nigrum l.) on the ...201121924548
influence of piperine on ibuprofen induced antinociception and its pharmacokinetics.piperine (cas 94-62-2), an alkaloid obtained from piper nigrum and p. longum, is a known inhibitor of various enzymes (cyp isozymes) responsible for biotransformation of drugs. by inhibiting the metabolism of drugs, piperine improves the bioavailability of drugs. in the present study piperine (10 mg/kg) significantly increased the dose-dependent antinociceptive activity of ibuprofen evaluated by both acetic acid writhing and formalin test, when it was administered with ibuprofen. ibuprofen plasm ...201122029226
green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis.leukocyte infiltration, up-regulation of proinflammatory cytokines and severe oxidative stress caused by increased amounts of reactive oxygen species are characteristics of inflammatory bowel disease. the catechin (2r,3r)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-1(2h)-benzopyran-3,5,7-triol-3-(3,4,5-trihydroxybenzoate), named epigallocatechin-3-gallate, egcg, has been demonstrated to exert anti-inflammatory and antioxidative properties, reducing reactive oxygen species in the inflamed tissues. the ...201122325177
suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of pkca/erk1/2-dependent matrix metalloproteinase-9 expression.piperine is a major component of black pepper, piper nigrum linn, used widely in traditional medicine. several previous studies reported that piperine possesses various beneficial biological activities including antioxidant, anti-tumor and anti-inflammation properties. in the present study, we investigated the inhibitory effects of piperine on tumor invasion and migration and the possible mechanisms involved using human fibrosarcoma ht-1080 cells. we found that piperine suppresses pma-enhanced m ...201121354279
antibacterial activity of natural spices on multiple drug resistant escherichia coli isolated from drinking water, bangladesh.spices traditionally have been used as coloring agents, flavoring agents, preservatives, food additives and medicine in bangladesh. the present work aimed to find out the antimicrobial activity of natural spices on multi-drug resistant escherichia coli isolates.201121406097
piperine, a piperidine alkaloid from piper nigrum re-sensitizes p-gp, mrp1 and bcrp dependent multidrug resistant cancer cells.over-expression of p-gp, mrp1 and bcrp in tumor cells is one of the important mechanisms leading to multidrug resistance (mdr), which impairs the efficacy of chemotherapy. p-gp, mrp1 and bcrp are abc (atp-binding cassette) transporters, which can expel a variety of lipophilic anti-cancer drugs and protect tumor cells. during a screening of mdr reversal agents among alkaloids of various structural types, a piperidine alkaloid, piperine (a main piperidine alkaloid in piper nigurm) was identified a ...201121802927
Safety assessment of Zanthoxylum alatum Roxb. essential oil, its antifungal, antiaflatoxin, antioxidant activity and efficacy as antimicrobial in preservation of Piper nigrum L. fruits.The investigation deals with antifungal, antiaflatoxin and antioxidant efficacy of Zanthoxylum alatum Roxb. essential oil (EO), its two major constituents and their comparison with five commonly used organic acid preservatives. The chemical profile of EO, characterized through GC and GC-MS analysis, revealed linalool (56.10%) and methyl cinnamate (19.73%) as major components. The EO, linalool and methyl cinnamate completely inhibited the growth of a toxigenic strain of A. flavus (LHP-10) as well ...201122137251
acetylcholinesterase inhibitory activity of thai traditional nootropic remedy and its herbal ingredients.the incidence of alzheimer disease (ad) is increasing every year in accordance with the increasing of elderly population and could pose significant health problems in the future. the use of medicinal plants as an alternative prevention or even for a possible treatment of the ad is, therefore, becoming an interesting research issue. acetylcholinesterase (ache) inhibitors are well-known drugs commonly used in the treatment of ad. the aim of the present study was to screen for ache inhibitory activ ...201122619927
potential mechanisms of hypocholesterolaemic effect of thai spices/dietary extracts.several thai spices/dietary ingredients were previously shown to have hypocholesterolaemic effects. these studies were mostly conducted in animal models in which the mechanisms of action were not yet well-established. therefore, this study aimed to investigate the potential mechanism of hypocholesterolaemic action of 12 selected plants, namely hibiscus sabdariffa l., moringa oleifera lam., cucurbita moschata duchesne, ananas comosus (l.) merr., zingiber officinale, morus alba l., camellia sinens ...201120623425
potent α-amylase inhibitory activity of indian ayurvedic medicinal plants.indian medicinal plants used in the ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via control of starch breakdown. in this study, seventeen indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory po ...201121251279
studies on the effects of phosphine on salmonella enterica serotype enteritidis in culture medium and in black pepper (piper nigrum).the effect of phosphine on salmonella enterica serotype enteritidis inoculated in culture medium and in black pepper grains (piper nigrum), as well as on the reduction of the microbial load of the dried and moisturized product, was verified. the postfumigation effect was verified in inoculated samples with 0.92 and 0.97 water activity (a(w)) exposed to 6 g/m(3) phosphine for 72 h, dried to 0.67 a(w), and stored for 24, 48, and 72 h. no decreases were observed in salmonella enteritidis population ...201121477485
involvement of serotonergic system in the antidepressant-like effect of piperine.piperine is a major alkaloid of black pepper (piper nigrum linn.) and long pepper (p. longum linn.), and its antidepressant-like effect has been previously demonstrated. the purpose of this study was to explore the possible contribution of the serotonergic system in the antidepressant-like effect of piperine in mice. the results showed that piperine significantly reduced the immobility time in the forced swim test and tail suspension test in mice. the anti-immobility effect of piperine in the fo ...201121477634
a randomised double-blind placebo-controlled study on the effects of a herbal toothpaste on gingival bleeding, oral hygiene and microbial variables.different systems of traditional medicine of the indian subcontinent, have used acacia chundra willd, adhatoda vasica nees., mimusops elengi l., piper nigrum l., pongamia pinnata l. pirerre, quercus infectoria olivier., syzygium aromaticum l., terminalia chebula retz., zingiber officinale roscoe., individually or in combinations, to cure oral diseases.201121542426
Selective molecular sequestration with concurrent natural product functionalization and derivatization: from crude natural product extracts to a single natural product derivative in one step.A resin-bound nitroso compound sequestered a single unexpected component from crude plant seed extracts. Several plants, including Piper nigrum, Eugenia caryophyllata, and Pimenta dioica, were extracted with organic solvent in the presence of a nitroso-containing resin. The nitroso resin selectively sequestered a single compound, ß-caryophyllene, via a chemo- and regioselective ene reaction. The ene product was released from the resin, and proper selection of the solid-phase linker and cleavage ...201122059469
Insecticidal activity of isobutylamides derived from Piper nigrum against adult of two mosquito species, Culex pipiens pallens and Aedes aegypti.The insecticidal activity of Piper nigrum fruit-derived piperidine alkaloid (piperine) and N-isobutylamide alkaloids (pellitorine, guineensine, pipercide and retrofractamide A) against female adults of Culex pipiens pallens and Aedes aegypti was examined. On the basis of 24-h LD(50) values, the compound most toxic to female C. pipiens pallens was pellitorine (0.4?µg/?) followed by guineensine (1.9?µg/?), retrofractamide A (2.4?µg/?) and pipercide (3.2?µg/?). LD(50) value of chlorpyrifos was 0.03 ...201122010905
medico - botanical study of yercaud hills in the eastern ghats of tamil nadu, india.the study reports medicinal plant survey was conceded in yercaud hills ranges of eastern ghats, tamil nadu, india. the study primarily based on field surveys conducted throughout the hills, where dwellers provided information on plant species used as medicine, plant parts used to prepare the remedies and ailments to which the remedies were prescribed. the study resulted about 48- plant species belonging to 45- genera and 29- families of medicinal plants related to folk medicine used by the local ...201122557438
flash chromatography on cartridges for the separation of plant extracts: rules for the selection of chromatographic conditions and comparison with medium pressure liquid chromatography.empirical rules for the selection of chromatographic conditions on flash chromatography cartridges were developed, with an emphasis on gradient mode. these rules were then tested with separation of extracts from important medicinal plants including curcuma xanthorrhiza, piper nigrum and salvia milthiorrhiza. sepacore® cartridges enabled a good separation of compounds with a broad range of polarity, as typically found in plant extracts. the chromatographic resolution remained, however, lower than ...201120804823
simultaneous determination of bioactive compounds in piper nigrum l. and a species comparison study using hplc-pda.piper nigrum l. is a traditional medicine widely used in india for illnesses such as constipation, diarrhoea, earache, gangrene, heart disease, hernia, hoarseness, indigestion, insect bites, insomnia, joint pain, liver problems, lung disease, oral abscesses, sunburn, tooth decay and toothaches. in this study, six bioactive compounds, namely piperine (1), pellitorine (2), guineensine (3), pipnoohine (4), trichostachine (5) and piperonal (6) were quantified in different extracts of p. nigrum l. an ...201121854175
larvicidal and repellent activity of medicinal plant extracts from eastern ghats of south india against malaria and filariasis vectors.to evaluate the larvicidal and repellent activities of ethyl acetate and methanol extracts of acacia concinna (a. concinna), cassia siamea (c. siamea), coriandrum sativum (c. sativum),cuminum cyminum (c. cyminum), lantana camara (l. camara), nelumbo nucifera (n. nucifera) phyllanthus amarus (p. amarus), piper nigrum (p. nigrum) and trachyspermum ammi (t. ammi) against anopheles stephensi (an. stephensi) and culex quinquefasciatus (cx. quinquefasciatus).201121967692
Studies on antimicrobial activities of solvent extracts of different spices.The antimicrobial activities of the ethyl acetate, acetone and methanol extract of 12 plant species were studied. The extract of Capsicum annuum (red pepper) (fruit) Zingiber officinale (ginger) (root), Cuminum cyminum (cumin), Alpinia ficinarum (galingale), Coriandrum sativum (coriander), Cinnamomun zeylanicum Nees (cinnamomun), Origanum onites L. (thyme), Folium sennae (senna), Eugenia caryophyllata (cloves), Flos tiliae (lime), Folium menthae crispae (peppermint) and Piper nigrum (blackpepper ...201121882663
mediation of cholino-piperine like receptors by extracts of piper nigrum induces melanin dispersion in rana tigerina tadpole melanophores.the present study was carried out to determine the effects of lyophilized dried fruit extracts of piper nigrum and pure piperine on the tadpole melanophores of frog rana tigerina which offer excellent in vitro opportunities for studying the effects of pharmacological and pharmaceutical agents. the nature of specific cellular receptors present on the neuro-melanophore junction and their involvement in pigmentary responses has been explored.201121663558
piperine ameliorates the severity of cerulein-induced acute pancreatitis by inhibiting the activation of mitogen activated protein kinases.piperine is a phenolic component of black pepper (piper nigrum) and long pepper (piper longum), fruits used in traditional asian medicine. our previous study showed that piperine inhibits lipopolysaccharide-induced inflammatory responses. in this study, we investigated whether piperine reduces the severity of cerulein-induced acute pancreatitis (ap). administration of piperine reduced histologic damage and myeloperoxidase (mpo) activity in the pancreas and ameliorated many of the examined labora ...201121663734
documentation and quantitative analysis of the local knowledge on medicinal plants among traditional siddha healers in virudhunagar district of tamil nadu, india.india has a population with high degree of medical pluralism. siddha system of indian traditional medicine is practiced dominantly by the people in tamil nadu. the traditionally trained siddha healers still play an important role in the rural health care. their knowledge is comparatively more vulnerable than the documented traditional knowledge. thus, the present study was aimed to document and quantitatively analyze the local knowledge of the traditional siddha healers in virudhunagar district ...201121718779
piperine, the main alkaloid of thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of alzheimer's disease.recently, numerous medicinal plants possessing profound central nervous system effects and antioxidant activity have received much attention as food supplement to improve cognitive function against cognitive deficit condition including in alzheimer's disease condition. based on this information, the effect of piperine, a main active alkaloid in fruit of piper nigrum, on memory performance and neurodegeneration in animal model of alzheimer's disease have been investigated. adult male wistar rats ...201020034530
tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats.curcumin, capsaicin and piperine--the bioactive compounds present in spices--turmeric (curcuma longa), red pepper (capsicum annuum) and black pepper (piper nigrum) respectively, have a considerable portion of structural homology. tissue distribution and elimination of these three structurally similar bioactive compounds was examined following their oral intake in rats.201020516541
hplc-based activity profiling: discovery of piperine as a positive gaba(a) receptor modulator targeting a benzodiazepine-independent binding site.a plant extract library was screened for gaba(a) receptor activity making use of a two-microelectrode voltage clamp assay on xenopus laevis oocytes. an ethyl acetate extract of black pepper fruits [piper nigrum l. (piperaceae) 100 microg/ml] potentiated gaba-induced chloride currents through gaba(a) receptors (composed of alpha(1), beta(2), and gamma(2s) subunits) by 169.1 +/- 2.4%. with the aid of an hplc-based activity profiling approach, piperine (5) was identified as the main active compound ...201020085307
adsorption and removal kinetics of phosphonate from water using natural adsorbents.the removal of phosphonate from water was studied using some natural adsorbents. potassium phosphonate is a fungicide used for the control of phytophthora capsici, which is prevalent in black pepper (piper nigrum l.). batch adsorption kinetic experiments were conducted on the adsorption of phosphonate onto the adsorbents. the concentration of phosphonate was measured on a high-performance liquid chromatograph fitted with a conductivity detector. the percentage removal of phosphonate by powdered ...201020112539
inhibition of chemiluminescence and chemotactic activity of phagocytes in vitro by the extracts of selected medicinal plants.the methanol extracts of 20 selected medicinal plants were investigated for their effects on the respiratory burst of human whole blood, isolated human polymorphonuclear leukocytes (pmns) and isolated mice macrophages using a luminol/lucigenin-based chemiluminescence assay. we also tested the effect of the extracts on chemotactic migration of pmns using the boyden chamber technique. the extracts of curcuma domestica l., phyllanthus amarus schum & thonn and c. xanthorrhiza roxb. were the samples ...201021184195
in vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (piper nigrum) and cardamom (elettaria cardamomum).although the immunomodulatory effects of many herbs have been extensively studied, research related to possible immunomodulatory effects of various spices is relatively scarce. here, the potential immunomodulatory effects of black pepper and cardamom are investigated. our data show that black pepper and cardamom aqueous extracts significantly enhance splenocyte proliferation in a dose-dependent, synergistic fashion. enzyme-linked immunosorbent assay experiments reveal that black pepper and carda ...201020210607
pellitorine, a potential anti-cancer lead compound against hl6 and mct-7 cell lines and microbial transformation of piperine from piper nigrum.pellitorine (1), which was isolated from the roots of piper nigrum, showed strong cytotoxic activities against hl60 and mct-7 cell lines. microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). two other alkaloids were also found from piper nigrum. they are (e)-1-[3',4'-(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). these compounds were isolated using chromatographic methods and their struc ...201020428051
inhibition of lipopolysaccharide-induced inflammatory responses by piperine.piperine, a main component of piper longum linn. and piper nigrum linn., is a plant alkaloid with a long history of medical use. piperine exhibits anti-inflammatory activity; however, the underlying mechanism remains unknown. we examined the effects of piperine on lipopolysaccharide (lps)-induced inflammatory responses. administration of piperine inhibited lps-induced endotoxin shock, leukocyte accumulation and the production of tumor necrosis factor-alpha (tnf-alpha), but not of interleukin (il ...201020621590
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