Publications

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foot-and-mouth disease virus induces lysosomal degradation of host protein kinase pkr by 3c proteinase to facilitate virus replication.the interferon-induced double-strand rna activated protein kinase (pkr) plays important roles in host defense against viral infection. here we demonstrate the significant antiviral role of pkr against foot-and-mouth disease virus (fmdv) and report that fmdv infection inhibits pkr expression and activation in porcine kidney (pk-15) cells. the viral nonstructural protein 3c proteinase (3c(pro)) is identified to be responsible for this inhibition. however, it is independent of the well-known protei ...201728662438
isolation, identification and retrospective study of foot-and-mouth disease virus from affected mithun (bos frontalis) in north-eastern india.foot-and-mouth disease (fmd) is a contagious disease of cloven-hoofed animals that causes substantial and perpetual economic loss. apart from the contagious nature of the disease, the fmd virus can establish in a "carrier state" among all cloven-hoofed animals. the mithun (bos frontalis), popularly called the "cattle of mountain," is found in the geographically isolated, hilly region of north-east india: arunachal pradesh, nagaland, manipur and mizoram. despite the geographical inaccessibility, ...201728707820
negative regulation of hepatic inflammation by the soluble resistance-related calcium-binding protein via signal transducer and activator of transcription 3.host immune response is tightly controlled by negative regulators to avoid excessive immune reactions for homeostasis. some pathogens may take advantage of host negative regulating system to evade host defense. our previous report showed that foot-and-mouth disease virus (fmdv) vp1 inhibited tnf-α- and sev-induced type i interferon response via interaction with cellular protein soluble resistance-related calcium-binding protein (sorcin). conversely, tnf-α- or sev-induced type i interferon respon ...201728706517
adoption of the 2a ribosomal skip principle to tobacco mosaic virus for peptide display.plant viruses are suitable as building blocks for nanomaterials and nanoparticles because they are easy to modify and can be expressed and purified using plants or heterologous expression systems. plant virus nanoparticles have been utilized for epitope presentation in vaccines, for drug delivery, as nanospheres and nanowires, and for biomedical imaging applications. fluorescent protein fusions have been instrumental for the tagging of plant virus particles. the monomeric non-oxygen-dependent fl ...201728702043
enhanced sensitivity in detection of antiviral antibody responses using biotinylation of foot-and-mouth disease virus (fmdv) capsids.analysis of the immune response to infection of livestock by foot-and-mouth disease virus (fmdv) is most often reported as the serum antibody response to the virus. while measurement of neutralizing antibody has been sensitive and specific, measurements of the quality of the antibody response are less robust. determining the immunoglobulin (ig) isotype of the serum antibody response provides a deeper understanding of the biology of the response and more sensitive methods for these assays will fa ...201728689695
inter-laboratory validation of foot-and-mouth disease diagnostic capability in germany.germany has been free from foot-and-mouth disease virus (fmdv) without vaccination since 1992, but diagnostic capability at regional laboratories is maintained for fmdv exclusion in suspect cases and as surge capacity for outbreak preparedness. a proficiency test was initiated in 2015 to evaluate the diagnostic performance of 20 regional veterinary laboratories. a panel of two identical samples of fmdv genome for real-time reverse transcription polymerase chain reaction (rt-pcr), four lyophilize ...201728619169
preserved immunogenicity of an inactivated vaccine based on foot-and-mouth disease virus particles with improved stability.foot-and-mouth disease virus (fmdv) is the etiological agent of a highly contagious disease that affects important livestock species. vaccines based on inactivated fmdv virions provide a useful tool for the control of this pathogen. however, long term storage at 4°c (the temperature for vaccine storage) or ruptures of the cold chain, provoke the dissociation of virions, reducing the immunogenicity of the vaccine. an fmdv mutant carrying amino acid replacements vp1 n17d and vp2 h145y isolated pre ...201728619156
preclinical diagnosis: predicting its ability to improve control of farm-to-farm foot-and-mouth disease transmission in cattle.foot-and-mouth disease (fmd) can cause large disruptive epidemics in livestock. current eradication measures rely on the rapid clinical detection and removal of infected herds. here, we have evaluated the potential for preclinical diagnosis during reactive surveillance to reduce the risk of between farm transmission. we used data from transmission experiments in cattle where both individual animal samples, such as blood, probang, saliva or nasal swabs, and herd level samples, such as air samples ...201728330886
recombinant human adenovirus-5 expressing capsid proteins of indian vaccine strains of foot-and-mouth disease virus elicits effective antibody response in cattle.recombinant adenovirus-5 vectored foot-and-mouth disease constructs (ad5- fmd) were made for three indian vaccine virus serotypes o, a and asia 1. constructs co-expressing foot-and- mouth disease virus (fmdv) capsid and viral 3c protease sequences, were evaluated for their ability to induce a neutralizing antibody response in indigenous cattle (bos indicus). purified ad5-fmd viruses were inoculated in cattle as monovalent (5×10(9) pfu/animal) or trivalent (5×10(9) pfu/animal per serotype) vaccin ...201728619144
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