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spontaneous mutations in the env gene of the human immunodeficiency virus type 1 ndk isolate are associated with a cd4-independent entry phenotype.human immunodeficiency virus type 1 (hiv-1) entry into target cells is a multistep process initiated by envelope protein gp120 binding to cell surface cd4. the conformational changes induced by this interaction likely favor a second-step interaction between gp120 and a coreceptor such as cxcr4 or ccr5. here, we report a spontaneous and stable cd4-independent entry phenotype for the hiv-1 ndk isolate. this mutant strain, which emerged from a population of chronically infected cd4-positive cem cel ...19989420253
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