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human transferrin receptor triggers an alternative tacaribe virus internalization pathway.tacaribe virus (tcrv) entry occurs by receptor-mediated endocytosis. to explore the entry mechanism used by tcrv, the inhibitory effects of drugs and dominant negative (dn) constructions affecting the main endocytic pathways were analyzed. in cells lacking the human transferrin receptor (htfr), compounds and dn proteins that impair clathrin-mediated endocytosis were shown to reduce virus internalization without affecting virion binding. in contrast, in cells expressing the htfr, compounds that a ...201626559962
differential contributions of tacaribe arenavirus nucleoprotein n-terminal and c-terminal residues to nucleocapsid functional activity.the arenavirus nucleoprotein (np) is the main protein component of viral nucleocapsids and is strictly required for viral genome replication mediated by the l polymerase. homo-oligomerization of np is presumed to play an important role in nucleocapsid assembly, albeit the underlying mechanism and the relevance of np-np interaction in nucleocapsid activity are still poorly understood. here, we evaluate the contribution of the new world tacaribe virus (tcrv) np self-interaction to nucleocapsid fun ...201424696466
inhibition of a/human/hubei/3/2005 (h3n2) influenza virus infection by silver nanoparticles in vitro and in vivo.silver nanoparticles (agnps) have attracted much attention as antimicrobial agents and have demonstrated efficient inhibitory activity against various viruses, including human immunodeficiency virus, hepatitis b virus, and tacaribe virus. in this study, we investigated if agnps could have antiviral and preventive effects in a/human/hubei/3/2005 (h3n2) influenza virus infection. madin-darby canine kidney cells infected with agnp-treated h3n2 influenza virus showed better viability (p<0.05 versus ...201324204140
tacaribe virus causes fatal infection of an ostensible reservoir host, the jamaican fruit bat.tacaribe virus (tcrv) was first isolated from 11 artibeus species bats captured in trinidad in the 1950s during a rabies virus surveillance program. despite significant effort, no evidence of infection of other mammals, mostly rodents, was found, suggesting that no other vertebrates harbored tcrv. for this reason, it was hypothesized that tcrv was naturally hosted by artibeus bats. this is in stark contrast to other arenaviruses with known hosts, all of which are rodents. to examine this hypothe ...201222379103
identification of critical amino acids within the nucleoprotein of tacaribe virus important for anti-interferon activity.the arenavirus nucleoprotein (np) can suppress induction of type i interferon (ifn). this anti-ifn activity is thought to be shared by all arenaviruses with the exception of tacaribe virus (tcrv). to identify the tcrv np amino acid residues that prevent its ifn-countering ability, we created a series of np chimeras between residues of tcrv np and pichinde virus (picv) np, an arenavirus np with potent anti-ifn function. chimera np analysis revealed that a minimal four amino acid stretch derived f ...201323382389
hematologic values of jamaican fruit bats (artibeus jamaicensis) and the effects of isoflurane anesthesia.jamaican fruit bats (artibeus jamaicensis) are used as an animal model for several viruses, including middle east respiratory syndrome virus, dengue virus, zika virus, and tacaribe virus. however, despite ongoing studies regarding these pathogens, little is known regarding the bats' normal physiology. in this study, phlebotomy of the propetagial (cephalic) vein was performed to establish baseline hematologic parameters in an apparently healthy, captive population of jamaican fruit bats. furtherm ...202032164795
development of a reverse genetic system to generate recombinant chimeric tacaribe virus that expresses junín virus glycoproteins.mammarenaviruses are enveloped and segmented negative-stranded rna viruses that comprise several pathogenic members associated with severe human hemorrhagic fevers. tacaribe virus (tcrv) is the prototype for the new world group of mammarenaviruses and is not only naturally attenuated but also phylogenetically and antigenically related to all south american pathogenic mammarenaviruses, particularly the junín virus (junv), which is the etiological agent of argentinian hemorrhagic fever (ahf). more ...202033203040
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