| complete nucleotide sequences of the m and s segments of two hantavirus isolates from california: evidence for reassortment in nature among viruses related to hantavirus pulmonary syndrome. | we report the complete nucleotide sequence of the m and the s genome segments and a portion of the l segments of two hantavirus isolates from peromyscus maniculatus trapped in eastern california. the isolates, convict creek 107 and 74 (cc107 and cc74) are genetically similar to viruses known to cause hantavirus pulmonary syndrome in new mexico. cc107 and cc74 each have an m segment consisting of 3696 nucleotides with a coding potential of 1140 amino acids in the virus complementary-sense rna (cr ... | 1995 | 7856108 |
| [hantavirus disease: an emerging infection]. | | 1994 | 7865553 |
| etiology and epidemiology of the four corners hantavirus outbreak. | in may and june 1993, a handful of previously healthy residents of rural areas in the four corners region of the southwestern united states died of acute unexplained respiratory distress, later diagnosed as hantavirus pulmonary syndrome. their illnesses were characterized most prominently by a prodrome of fever and myalgias, followed by thrombocytopenia, the presence of immature white blood cells on the peripheral smear, and catastrophic respiratory decline associated with the sudden onset of no ... | 1994 | 7866656 |
| seroprevalence study of hantavirus antibodies in pima indians with renal disease. | | 1995 | 7876639 |
| hantavirus pulmonary syndrome. outbreak of a new disease caused by a new virus. | only months after the first report of a brief prodromal illness followed by rapidly progressive noncardiogenic pulmonary edema and death, the causative agent was tentatively identified as a previously unknown hantavirus. although hantaviral infections are well known in asia, none had ever been reported in the united states. a collaborative effort between local, state, regional, and federal authorities allowed rapid identification of a new set of clinical and laboratory findings, now known as the ... | 1995 | 7877921 |
| [hantavirus: a new pandemic?]. | | 1994 | 7885196 |
| hantavirus pulmonary syndrome is here. | | 1995 | 7885708 |
| control of hantavirus in the west. | | 1995 | 7884947 |
| evidence of hantavirus infection in rodents and human beings from connecticut and new york, usa. | | 1995 | 7885165 |
| raised plasma endothelin-1 concentration in patients with nephropathia epidemica. | nephropathia epidemica (ne) with renal syndrome, caused by the puumala-virus, is manifested clinically by the triad of fever, hemorrhage and renal failure. we observed raised plasma concentrations of endothelin-1 (et-1) and atrial natriuretic peptide (anp) in 23 patients during the acute phase of ne. they all developed transient renal failure and all displayed characteristics of ne, also verified by a rapid igg antibody test. blood pressure was normal or low in all subjects during the acute phas ... | 1993 | 7900944 |
| [hantavirus infections 1993: endemic or unrecognized pandemic?]. | | 1993 | 7900981 |
| prevalence and geographic genetic variation of hantaviruses of new world harvest mice (reithrodontomys): identification of a divergent genotype from a costa rican reithrodontomys mexicanus. | we recently described a novel hantavirus (hmv-1) of the western harvest mouse reithrodontomys megalotis. screening of 181 additional specimens of reithrodontomys from the united states and mexico, including samples of r. mexicanus, r. sumichrasti, and r. gracilis of costa rica, for antibodies to hantavirus nucleocapsid protein revealed a widespread enzootic of hantavirus infection. genetic analyses of 7 s genomes of reithrodontomys-associated hantaviruses demonstrated that the enzootic of hmv-1 ... | 1995 | 7886948 |
| hantavirus pulmonary syndrome. pathogenesis of an emerging infectious disease. | a recent outbreak of a severe pulmonary disease in the southwestern united states was etiologically linked to a previously unrecognized hantavirus. the virus has been isolated from its major reservoir, the deer mouse, peromyscus maniculatus, and recently named sin nombre virus. clinically, the disease has become known as the hantavirus pulmonary syndrome (hps). since may 1993, 44 fatal cases of hps have been identified through clinicopathological review and immunohistochemical (ihc) testing of t ... | 1995 | 7887439 |
| hantavirus pulmonary syndrome in california: report of two cases and investigation. | we report two cases of hantavirus pulmonary syndrome that were probably acquired in california. genetic analysis of tissue specimens from one of the patients revealed that the virus isolated is a variant of the strain (sin nombre virus) identified in the outbreak of hantavirus pulmonary syndrome that occurred in the four corners region of the southwestern united states in 1993. in addition to presenting the clinical features of the two cases, we discuss the possible risk factors for infection. | 1994 | 7888541 |
| update: hantavirus disease--united states, 1993. | | 1993 | 7902158 |
| comparison of virulence between seoul virus strain sr-11 and hantaan virus strain 76-118 of hantaviruses in newborn mice. | virulence of hantavirus strain of sr-11 seoul virus and hantaan 76-118 (htn) of hantaan virus were compared. infections of both strains were lethal in newborn mice. however, inoculum required to cause lethal infection was about 4,000 times higher for strain htn (1.65 x 10(3) pfu/mouse/ld50) than for strain sr-11 (0.36 pfu). thus, both strains were considered pathogenic to newborn mice but they possessed different levels of virulence. the assay system used for these strains in newborn mice proved ... | 1993 | 7901740 |
| hantavirus disease emerging. | | 1993 | 7901592 |
| [distribution of extracellular viral antigen of epidemic hemorrhagic fever in human autopsy cases]. | using improved immunohistochemical methods, repeated pap and repeated pap + abc, we found in the extracellular spaces of autopsy cases of epidemic hemorrhagic fever large amount of viral antigens. two forms of antigens were found: diffuse soluble antigen and inclusion body like granular antigen. the former was mainly g2 protein and the latter was mainly n protein. they were found in serum, lymph, csf, edema fluid, fluids in renal, seminal tubules, alveolar and bronchial spaces, peptic, intestina ... | 1993 | 7903062 |
| p53 sweeps through cancer research. | | 1993 | 7903477 |
| epizootiological study of hantavirus infection among rattus norvegicus in tokyo bay area, japan. | the prevalence of antibodies against hantavirus in 413 rats (rattus norvegicus) captured in eight regions of the tokyo bay area from 1983 to 1992 were examined by the indirect fluorescent antibody test. antibody-positive rats were found in tokyo port in 1983 (34.8%), 1984 (25.9%), 1985 (22.0%) and 1986 (15.6%), in kasai seaside park in 1989 (3.2%) and 1990 (4.2%) and in chiba port in 1990 (6.7%). in tokyo port, antibody-positive rats were found in any season in 1984 and 1985, and seroprevalences ... | 1993 | 7903711 |
| hantavirus epidemic in europe, 1993. | | 1994 | 7903742 |
| hantavirus epidemic in europe, 1993. | | 1994 | 7903743 |
| hantavirus epidemic in europe, 1993. | | 1994 | 7903744 |
| guillain-barré syndrome associated with hantavirus infection. | | 1994 | 7904032 |
| antibodies to different strains of hantavirus in end-stage renal disease in usa and japan. | | 1994 | 7904033 |
| local host response in the lower respiratory tract in nephropathia epidemica. | various lines of evidence suggest a respiratory route of transmission of nephropathia epidemica (ne). to study the response of the respiratory tract in ne, fiberoptic bronchoscopy with bronchoalveolar lavage (bal) was performed in 5 patients in the acute phase of the disease. compared to a reference group of 15 healthy individuals, bal fluid of ne patients contained significantly higher total numbers of cells (p < 0.05) and significantly higher numbers of lysozyme-positive macrophages (p < 0.01) ... | 1993 | 7904380 |
| is "south-west us mystery disease" caused by hantavirus? | | 1994 | 7905062 |
| haemorrhagic fever with renal syndrome. | | 1993 | 7905615 |
| [viral infections--clinical pictures and laboratory diagnosis. part 3: hantaan virus and hantaan-related viruses, hepatitis a and b]. | | 1993 | 7905848 |
| acute hantavirus infection. | | 1993 | 7905899 |
| [von willebrand factor, antithrombin iii and 5'-nucleotidase in the blood and the athrombogenic properties of the vascular wall in patients with hemorrhagic fever with renal syndrome]. | willebrand's factor (wf), antithrombin iii (at-iii), blood 5'-nucleotidase and athrombogenic properties of the vascular wall were studied in the course of the disease in 69 patients suffering from hemorrhagic fever with renal syndrome (hfrs). the patients were chiefly under 27 years, had severe or moderate condition. it was found that wf rose 3-fold in oliguria, but returned to normal values by convalescence. at-iii remained stable. high activity of 5'-nucleotidase reached the pick in oliguria a ... | 1993 | 7906437 |
| application of a recombinant baculovirus expressing hantavirus nucleocapsid protein as a diagnostic antigen in ifa test: cross reactivities among 3 serotypes of hantavirus which causes hemorrhagic fever with renal syndrome (hfrs). | recombinant baculovirus-infected insect cells which expressed recombinant protein, analogous to the nucleocapsid protein (np) of seoul type hantavirus, strain sr-11 (rnp-sr-sf9) were applied to the indirect immunofluorescent antibody (ifa) test. the rnp-sr-sf9 reacted with anti np mab clones which recognized strain specific or hantavirus common epitopes in the ifa test. the recombinant antigen was detected by antibodies to 3 serotypes of hantaviruses (hantaan 76-118, sr-11, puumala). antibody ti ... | 1993 | 7906956 |
| [atypical pneumonia during hemorrhagic fever with renal syndrome]. | | 1993 | 7907181 |
| hantavirus: an old bug learns new tricks. | hantaviruses are a diverse group of rna arboviruses in the bunyaviridae family. although their role as the causative agents of hfrs has been well established, the recent outbreak of a new disease in the southwest clearly demonstrates the protein clinical manifestations that this pathogen can produce. furthermore, whereas hantaviruses have been characterized largely as focal agents in the production of geographically delimited diseases, recent trends indicate that endemic areas for the virus are ... | 1993 | 7907616 |
| hantavirus-associated illness identified in north dakota. | | 1993 | 7907617 |
| [report on detection of rats and humans with hfrs antibody in the faculty of medicine, kyoto university and on measures taken against the trouble]. | | 1993 | 7902816 |
| the domestic cat: a possible transmitter of viruses from rodents to man. | | 1994 | 7908383 |
| in utero and mammary transfer of hantavirus antibody from dams to infant rats. | the effects of maternal-infant transfer of specific antibody on infection attributable to hemorrhagic fever with renal syndrome-causing virus in the infant rat were studied. in cross-fostering experiments, maternal hantavirus-specific antibody was shown to be transferred equally effectively to infants either in utero or by breastfeeding. both igg- and iga-specific antibodies were transferred. infected infants that initially acquired high levels of maternal antibodies by either route survived let ... | 1993 | 7908999 |
| retrospective diagnosis of a 1983 case of fatal hantavirus pulmonary syndrome. | | 1994 | 7909065 |
| hantavirus nephropathy in greece. | | 1994 | 7909066 |
| [the level of ionized calcium in the blood and parathyroid function in acute kidney failure in patients with hemorrhagic fever with renal syndrome]. | in patients with haemorrhagic fever with renal syndrome (hfrs) and in those who had hfrs in the past ionized calcium (ca2+) and parathyroid hormone (pth) levels were measured in the blood. high levels of pth in normal or low those of ca2+ were typical for hfrs oliguria. hyperparathyroidism observed was assessed as an adaptation reaction preventing oliguria-related ca2+ fall. in cured patients neither ca2+ nor pth deviation were reported. | 1993 | 7909180 |
| antigenic and molecular characterization of hantavirus isolates from china. | hemorrhagic fever with renal syndrome (hfrs) is caused by certain viruses in the genus hantavirus, family bunyaviridae, and is a major public health problem in china. by using molecular and serological tests, we characterized 15 hantaviruses isolated either from patients with hfrs or from rodents captured in endemic areas of china. by cross plaque-reduction neutralization tests performed with rabbit immune sera, we identified two serologically distinct groups of viruses, comprised of those relat ... | 1994 | 7909976 |
| [the functional activity of neutrophilic granulocytes in hemorrhagic fever with renal syndrome]. | in blood samples taken from 33 patients having hemorrhagic fever with the renal syndrome (hfrs) the capacity of neutrophil granulocytes for the ingestion of bacteria and for the reduction of tetrazolium nitro blue, as well as the content of cation protein in the cytoplasm of neutrophils and the concentration of lysozyme in the blood serum of patients, were studied. the study revealed an increase in the values of the above characteristics in comparison with similar data obtained in healthy subjec ... | 1994 | 7910426 |
| renal biopsy findings and clinicopathologic correlations in nephropathia epidemica. | a series of 126 adult patients with a serologically confirmed diagnosis of nephropathia epidemica (ne) were studied during the acute phase of the disease. in 86 cases, renal biopsy was performed. the severity of renal failure correlated slightly with blood inflammatory parameters and the degree of hematuria but not with the amount of proteinuria. the degree of hematuria correlated inversely with the level of thrombocytopenia. the most common histopathologic lesion was acute tubulointerstitial ne ... | 1994 | 7910539 |
| nephropathia epidemica in finland: a retrospective study of 126 cases. | a total of 126 (99 males, 27 females) serologically confirmed hospital-treated adult cases of nephropathia epidemica (ne) were studied. the initial diagnosis suggested by the referring physician was correct in only 28%. some rare clinical manifestations of ne were observed; acute myopericarditis in 3 patients and encephalitis in 1. pulmonary involvement due to vascular congestion was observed in 16% and liver involvement in 34% of the patients. thrombocytopenia was present in 75%, leukocytosis i ... | 1994 | 7910705 |
| epizootiological studies of hantavirus infection among urban rats in hokkaido, japan: evidences for the persistent infection from the sero-epizootiological surveys and antigenic characterizations of hantavirus isolates. | epizootiological studies of hantavirus infection among urban rats were carried out through the surveys repeated 11 times at the same dumping ground area in 1983 to 1988. a total of 279 rats (rattus norvegicus) were captured during the surveys. sero-positive animals to hantavirus strain sr-11 were detected in all the surveys. overall positive rate of rats 6 months old or more (94/128, 73.4%) was significantly higher than that of younger rats (23/151, 15.2%, x2 = 96.4, p < 0.001). therefore, age d ... | 1994 | 7911335 |
| a rogues' gallery of hantaviruses. | | 1993 | 7901910 |
| identifying a hantavirus associated with acute respiratory illness: a pcr victory? | | 1993 | 7902477 |
| second international conference on hemorrhagic fever with renal syndrome. | | 1993 | 7908259 |
| hantavirus pulmonary syndrome: kansas, 1993. | | 1994 | 7911857 |
| rat-transmitted hantavirus disease in sarajevo. | | 1994 | 7912368 |
| virus-related acute renal failure: the clinical course and outcome of hemorrhagic fever with renal syndrome. | | 1994 | 7914707 |
| clinical quiz. nephropathia epidemica. specific igm antibodies against puumalavirus can be found in serum. | | 1994 | 7912543 |
| hantavirus infection. | | 1994 | 7913975 |
| retrospective and prospective studies of hemorrhagic fever with renal syndrome in rural china. | residents of two villages in zhejiang province, china, were interviewed and serum samples were collected to assess prevalence of hantavirus infection. antibody prevalence was 12% (219/1811), with a ratio of illness to infection of 1.0:5.4. seroprevalence increased with age, but no association was found with sex. there was also no evidence of vertical transmission. one year later, 2.3% (30/1325) of seronegative subjects had seroconverted including 2 who had hemorrhagic fever with renal syndrome. ... | 1994 | 7915747 |
| inability of a strain of seoul virus to transmit itself vertically in rats. | sr-11 strain of seoul virus was inoculated into new-born female rats. these rats at the age of 13 weeks were mated with uninfected male rats. the virus was transmitted to the male rats, but the offsprings were not infected from their mather rat owing to the maternal antibody. no intrauterine transmission of the virus was observed. we assumed that sr-11 type strain of seoul virus could not be disseminated among rats in nature. | 1993 | 7914245 |
| prevalence of serum igg antibodies to puumala virus (haemorrhagic fever with renal syndrome) in northern sweden. | a stratified and randomly-selected population sample was identified in 1990 in order to study the seroprevalence of nephropathia epidemica (haemorrhagic fever with renal syndrome) in northern sweden. sera from 1538 subjects (750 men, 788 women), 25-64 years of age, were analysed for the presence of puumala virus (puv) specific-igg by the indirect immunofluorescence antibody test. specific igg was detected in sera from 83 subjects (5.4%). men and women had similar seroprevalence rates. the highes ... | 1994 | 7914872 |
| [hemorrhagic fever with renal syndrome in the structure of natural-focus morbidity in the southern khabarovsk territory and its social significance]. | according to the data contained in the materials provided by the hospital of infectious diseases of the khabarovsk medical institute, in the recent decade hemorrhagic fever with the renal syndrome, together with pseudotuberculosis, played the leading role in the structure of morbidity caused by natural foci of infections. the distribution of patients in social groups and different important factors of the epidemiology of this disease are considered. taking into account a high morbidity level in ... | 1993 | 7915073 |
| [the urinary excretion of free amino acids in patients with hemorrhagic fever with renal syndrome]. | the authors detected impaired urinary excretion of some amino acids in 20 patients suffering from moderate hemorrhagic fever with renal syndrome. the excretory changes depended on the kind of amino acid, the disease period and renal function. the causes of the above abnormality are discussed. | 1994 | 7915862 |
| serological evidence of hantavirus disease in northern ireland. | since, to our knowledge, no clinically documented cases of haemorrhagic fever with renal syndrome (hfrs) have been reported in northern ireland, a sero-epidemiological study was carried out to assess the degree of hantavirus immunity in a group of 627 northern irish patients presenting with symptoms suggestive of hfrs and 100 healthy controls. ifa screening for igg hantavirus specific antibodies was carried out with a panel of up to 9 different hantaviral antigens. igm screening was performed us ... | 1994 | 7916033 |
| recommendations for hantavirus risk reduction. | | 1994 | 7920364 |
| class and subclass distribution of hantavirus-specific serum antibodies at different times after the onset of nephropathia epidemica. | sera from dutch and belgium individuals who suffered from nephropathia epidemica (ne), a mild form of haemorrhagic fever with renal syndrome (hfrs), were tested for the distribution of classes and subclasses of hantavirus (hv)-specific antibodies at different times after the onset of the disease, with class- and subclass-specific ig capture enzyme-linked immunosorbent assays (elisas). in the acute, early convalescent, and convalescent phases, predominantly specific iga, igm, and igg3 antibodies ... | 1994 | 7916034 |
| belgrade and hantaan hantaviruses--the causative agents of severe haemorrhagic fever with renal syndrome in children in serbia. | during an outbreak of haemorrhagic fever with renal syndrome (hfrs) in 1989, five children (3 girls, 2 boys, aged 6.8-16 years) with a severe form of the disease were treated; four of these were followed for 22-28 months. the main clinical features in all five patients were: fever, headache, myalgia, abdominal and back pain and vomiting; haemorrhagic syndrome was present in four children. renal syndrome presented with severe acute renal failure in all five patients. all patients recovered. serol ... | 1994 | 7917855 |
| first reported cases of hantavirus pulmonary syndrome in canada. | | 1994 | 7920363 |
| hantavirus disease. | | 1994 | 7923452 |
| hantavirus--are we ready? | | 1994 | 7936443 |
| [hantavirus infection without renal involvement]. | | 1994 | 7938973 |
| detection of muerto canyon virus rna in peripheral blood mononuclear cells from patients with hantavirus pulmonary syndrome. | to determine if muerto canyon virus (mcv) rna is present in the peripheral blood of patients with hantavirus pulmonary syndrome, a reverse transcriptase-polymerase chain reaction (rt-pcr) assay for mcv rna was used on blood samples from 20 seropositive case-patients. rna was prepared from peripheral blood mononuclear cells (pbmc) or blood clot (or both) from 19 and from plasma from 11 case-patients. all 12 blood clot, all 13 pbmc, and 8 of 11 plasma preparations produced an mcv amplification pro ... | 1994 | 7930697 |
| comparison of nucleotide sequences of m genome segments among seoul virus strains isolated from eastern asia. | the nucleotide sequences of the m genome segments of three seoul virus strains (ki strains) which were isolated from urban rats inhabiting the same enzootic focus between 1983 and 1988 were compared. the viral cdnas were amplified by pcr and were directly sequenced. the nucleotide sequences of ki strains were extremely homologous regardless of isolation year (less than 10 substitutions in 3651 nucleotides, less than 4 substitutions in 1133 amino acids). in addition, the nucleotide sequence of th ... | 1994 | 7941698 |
| rapid differentiation between hantaan and seoul viruses by polymerase chain reaction and restriction enzyme analysis. | the majority of causative strains of hemorrhagic fever with renal syndrome (hfrs) are known as hantaan and seoul viruses in korea. the clinical manifestations may be indistinguishable between both viruses, although the clinical course of hantaan virus infection is more severe than that of the seoul virus. therefore, the differentiation of hantaan or seoul virus may be important for predicting the prognosis. the primers were selected from the published sequences of the s segments of hantaan virus ... | 1994 | 7931185 |
| serologic and virologic evidence of a prospect hill-like hantavirus in wisconsin and minnesota. | the purposes of this study were to determine if hantaviruses were present in the great lakes port areas of wisconsin and minnesota and if so, to identify which virus and which rodent host species were involved. rodents were trapped in duluth, minnesota, superior, green bay, and milwaukee, wisconsin, all ports of call for international maritime shipping. a total of 675 wild rodents were captured and tested, including 310 meadow voles (microtus pennsylvanicus), 173 norway rats (rattus norvegicus), ... | 1994 | 7943546 |
| isolation of a strain of a hantaan virus from a fatal case of hemorrhagic fever with renal syndrome in slovenia. | hemorrhagic fever with renal syndrome (hfrs) has been serologically confirmed in slovenia during the last seven years. there is evidence that three hantaviruses (hantaan, puumala, and a newly described form termed dobrava) circulate simultaneously in this area. recently, a hantavirus was isolated from the urine and brain tissue of a fatal case of hfrs. positive immunofluorescent reactions with reference human sera and monoclonal antibodies were first recognized after the second cell culture pass ... | 1994 | 7943563 |
| genetic evidence for a hantavirus enzootic in deer mice (peromyscus maniculatus) captured a decade before the recognition of hantavirus pulmonary syndrome. | to determine if the emergence of hantavirus pulmonary syndrome in the united states was a consequence of recent amino-acid altering mutations and/or genetic reassortment with pathogenic hantaviruses, we examined lung and spleen tissues from seropositive deer mice trapped in august 1983 in mono county, california, for hantaviral rna by reverse transcriptase-directed polymerase chain reaction. alignment and comparison of 1485 nucleotides of the s and m genomic segments enzymatically amplified from ... | 1994 | 7941323 |
| hantavirus infection in the domestic cat. | | 1994 | 7933313 |
| hantavirus disease as a cause for hematuria and acute tubular necrosis? | | 1994 | 7942834 |
| hemorrhagic fever with renal syndrome: a study of sequelae following nephropathia epidemica. | sequelae following nephropathia epidemica (ne) were investigated in 792 individuals living in an endemic area of sweden. volunteers were tested for presence of puumala (puu) virus specific igg antibodies in serum, as well as several parameters linked with renal dysfunction and cardiovascular disease (systolic and diastolic blood pressure, ecg, bmi, total cholesterol and serum creatinine). no differences were seen in any of the variables tested between puu virus antibody positive (n = 110) and ne ... | 1994 | 7944947 |
| hantavirus pulmonary syndrome--virginia, 1993. | hantavirus pulmonary syndrome (hps) was first recognized in june 1993 as a result of the investigation of a cluster of fatal cases of adult respiratory distress syndrome (ards) in the southwestern united states (1). during that month, a 61-year-old man was admitted to a hospital in southern pennsylvania with ards; recent testing of all available specimens from this patient has confirmed the diagnosis of hps. this report summarizes the case investigation. | 1994 | 7969008 |
| hantavirus: an increasing problem? | hantaviruses are enveloped rna viruses and members of the bunyaviridae family. they are transmitted from various rodent hosts by inhalation of infected urine, saliva or faeces. infection in rodent hosts is inapparent but persists for life. person-to-person spread of hantavirus has not been described. two main presentations of the disease occur. haemorrhagic fever with renal syndrome (hfrs) is due to hantaan, seoul, puumala, porogia and belgrade viruses. in general hfrs due to hantaan, porogia an ... | 1994 | 7979621 |
| hantavirus: an overview and update. | | 1994 | 7983838 |
| isolation of pathogenic hantavirus from white-footed mouse (peromyscus leucopus) | | 1994 | 7984010 |
| from the centers for disease control and prevention. hantavirus pulmonary syndrome--virginia, 1993. | | 1994 | 7990229 |
| different transmissibility of 2 isolates of seoul virus from the same wild brown rat (rattus norvegicus). | two seoul virus strains were isolated from the same wild brown rat (rattus norvegicus) by 2 different procedures. while one isolate (tr-352) by means of a cell culture system had no horizontal transmissibility in 3-week-old rats, another isolate (tr-352r) by means of inoculation to newborn rats had transmissibility in rats. | 1994 | 7948388 |
| tula virus: a newly detected hantavirus carried by european common voles. | a novel hantavirus has been discovered in european common voles, microtus arvalis and microtus rossiaemeridionalis. according to sequencing data for the genomic rna s segment and nucleocapsid protein and data obtained by immunoblotting with a panel of monoclonal antibodies, the virus, designated tula virus, is a distinct novel member of the genus hantavirus. phylogenetic analyses of tula virus indicate that it is most closely related to prospect hill, puumala, and muerto canyon viruses. the resu ... | 1994 | 7966573 |
| association of serine in position 1124 of hantaan virus glycoprotein with virulence in mice. | hantaan virus (hv) of the genus hantavirus causes a fatal disease in suckling mice following intraperitoneal or intracerebral infection. hv cl-1, which was obtained from the 76-118 strain of hv by growth in vero e6 cells, exhibited high mortality rates in mice whereas mice infected with hv cl-2 survived without any clinical signs. to determine the molecular basis for the marked difference in virulence, we compared the nucleotide sequences of the large (l), medium (m) and small (s) segments of hv ... | 1994 | 7964639 |
| serological survey of hantavirus antibodies in chronic hemodialysis patients. | | 1994 | 7994941 |
| hantavirus. | | 1994 | 8003367 |
| hantavirus pulmonary syndrome. | | 1994 | 8004332 |
| genetic identification of a new puumala virus strain causing severe hemorrhagic fever with renal syndrome in germany. | a severe case of suspected hemorrhagic fever with renal syndrome (hfrs) was recently identified in northwestern germany. a genetic detection assay was designed that identified hantavirus-specific rna in the patient's clinical specimens by reverse transcriptase-polymerase chain reaction amplification of virus s and m genome segments. phylogenetic analysis of the nucleotide sequences demonstrated that this virus belonged to the puumala (puu) group, with the closest relationship to a puu isolate fr ... | 1994 | 7995985 |
| emerging infectious diseases in the united states, 1993. | three outbreaks of disease in the united states in 1993 caused by escherichia coli o157:h7, cryptosporidium organisms, and a previously unrecognized hantavirus clearly illustrate the increasing challenges posed by emerging infectious diseases. the largest us outbreak of e. coli o157:h7 infection reported occurred as a result of contaminated hamburgers served at a fast-food restaurant chain. the largest recorded waterborne disease outbreak in us history was due to contamination of a municipal wat ... | 1994 | 8035009 |
| hantavirus pulmonary syndrome--northeastern united states, 1994. | on january 20, 1994, a 22-year-old rhode island man died of acute respiratory distress approximately 5 hours after hospitalization. this report summarizes the case investigation. | 1994 | 8035772 |
| experimental transmission of hantavirus infection in laboratory rats. | this study found a competent transmission of hantavirus between cagemates using congenitally t cell-deficient rowett nude rats (rnu/rnu). intraperitoneally infected immunologically normal rats (rnu/+) did not transmit the hantavirus to their normal cagemates (rnu/+) but did to rowett nude rats (rnu/rnu). thus, nude rats were shown to be highly susceptible to the hantavirus infection. also, infected nude rats (rnu/rnu) discharged the infectious viruses, to cause a prevalence of infection among no ... | 1994 | 7996001 |
| seoul hantavirus seropositivity among injecting drug users in baltimore. | | 1994 | 7996013 |
| hantavirus pulmonary syndrome in indiana. | | 1994 | 8034959 |
| quarterly communicable disease review july to september 1993. from the phls communicable disease surveillance centre. | | 1994 | 8037941 |
| hantavirus pulmonary syndrome complicating pregnancy. | the purpose of this report is to bring to the attention of obstetric care providers the occurrence in pregnancy of a threatening pulmonary syndrome caused by hantavirus infection. | 1994 | 8059840 |
| isolation of the causative agent of hantavirus pulmonary syndrome. | investigation of a recent outbreak of acute respiratory illness in the southwestern united states resulted in the recognition of a new disease, hantavirus pulmonary syndrome (hps) with high mortality. different animals and cell lines were used in attempts to isolate the causative agent. a previously unknown hantavirus was passaged in laboratory-bred deer mice, recovered from lung tissues of a deer mouse, peromyscus maniculatus, and propagated in the e6 clone of vero cells. virus antigen was read ... | 1994 | 8059907 |
| hantavirus pulmonary syndrome in new england and europe. | | 1994 | 8041424 |
| hantavirus pulmonary syndrome in new england and europe. | | 1994 | 8041425 |
| preparing for emerging infections. | new infectious diseases continue to emerge, yet there is no clear strategy for managing them. a model response should be devised in the light of past events such as the recent us outbreak of a previously unknown hantavirus. | 1994 | 8047155 |
| hantavirus: emergency department response to a disaster from an emerging pathogen. | in may 1993, the appearance of critically ill patients with unexplained respiratory distress was noted in the four corners area formed by new mexico, arizona, and colorado. this epidemic was ultimately linked to a hantavirus, an emerging pathogen. the impact on the emergency department of a new infectious disease with respiratory distress is described. a model is proposed to manage infectious disease disasters. emerging infections that are important to emergency physicians are discussed. recomme ... | 1994 | 8080140 |