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enhancement of infectivity of hantavirus in cell culture by centrifugation.centrifugation was introduced during virus adsorption to vero e6 cells to improve the infectivity of hantavirus. centrifugal adsorption of a stock solution of hantaan virus strain 76-118 to a monolayer of vero e6 cells enhanced virus infectivity depending on the centrifugation time and the centrifugal force. the maximum level of infectivity (3.1 x 10(6) ffu/ml) was enhanced after a 2 h centrifugation at 671 x g, which was almost 9-times higher than that of conventional adsorption of the virus at ...19947822463
[hantavirus disease: an emerging infection]. 19947865553
seroprevalence study of hantavirus antibodies in pima indians with renal disease. 19957876639
evidence of hantavirus infection in rodents and human beings from connecticut and new york, usa. 19957885165
control of hantavirus in the west. 19957884947
hantavirus pulmonary syndrome is here. 19957885708
[hantavirus: a new pandemic?]. 19947885196
hantavirus pulmonary syndrome. pathogenesis of an emerging infectious disease.a recent outbreak of a severe pulmonary disease in the southwestern united states was etiologically linked to a previously unrecognized hantavirus. the virus has been isolated from its major reservoir, the deer mouse, peromyscus maniculatus, and recently named sin nombre virus. clinically, the disease has become known as the hantavirus pulmonary syndrome (hps). since may 1993, 44 fatal cases of hps have been identified through clinicopathological review and immunohistochemical (ihc) testing of t ...19957887439
hantavirus pulmonary syndrome. outbreak of a new disease caused by a new virus.only months after the first report of a brief prodromal illness followed by rapidly progressive noncardiogenic pulmonary edema and death, the causative agent was tentatively identified as a previously unknown hantavirus. although hantaviral infections are well known in asia, none had ever been reported in the united states. a collaborative effort between local, state, regional, and federal authorities allowed rapid identification of a new set of clinical and laboratory findings, now known as the ...19957877921
prevalence and geographic genetic variation of hantaviruses of new world harvest mice (reithrodontomys): identification of a divergent genotype from a costa rican reithrodontomys mexicanus.we recently described a novel hantavirus (hmv-1) of the western harvest mouse reithrodontomys megalotis. screening of 181 additional specimens of reithrodontomys from the united states and mexico, including samples of r. mexicanus, r. sumichrasti, and r. gracilis of costa rica, for antibodies to hantavirus nucleocapsid protein revealed a widespread enzootic of hantavirus infection. genetic analyses of 7 s genomes of reithrodontomys-associated hantaviruses demonstrated that the enzootic of hmv-1 ...19957886948
hantavirus pulmonary syndrome in california: report of two cases and investigation.we report two cases of hantavirus pulmonary syndrome that were probably acquired in california. genetic analysis of tissue specimens from one of the patients revealed that the virus isolated is a variant of the strain (sin nombre virus) identified in the outbreak of hantavirus pulmonary syndrome that occurred in the four corners region of the southwestern united states in 1993. in addition to presenting the clinical features of the two cases, we discuss the possible risk factors for infection.19947888541
risk of infections transmitted by arthropods and rodents in forestry workers.one hundred and fifty-one forestry workers and 151 matched office clerks were compared as to the presence of antibodies against borelia burgdorferi, tick-borne encephalitis virus, puumalavirus and lymphocytic choriomeningitis virus. their occupational risks of being infected by borrelia was fourfold and significant, by puumalavirus and lymphocytic choriomeningitis virus was increased but not significant. no seropositivity has been established against tick-borne encephalitis virus.19947859849
comparison of virulence between seoul virus strain sr-11 and hantaan virus strain 76-118 of hantaviruses in newborn mice.virulence of hantavirus strain of sr-11 seoul virus and hantaan 76-118 (htn) of hantaan virus were compared. infections of both strains were lethal in newborn mice. however, inoculum required to cause lethal infection was about 4,000 times higher for strain htn (1.65 x 10(3) pfu/mouse/ld50) than for strain sr-11 (0.36 pfu). thus, both strains were considered pathogenic to newborn mice but they possessed different levels of virulence. the assay system used for these strains in newborn mice proved ...19937901740
raised plasma endothelin-1 concentration in patients with nephropathia epidemica.nephropathia epidemica (ne) with renal syndrome, caused by the puumala-virus, is manifested clinically by the triad of fever, hemorrhage and renal failure. we observed raised plasma concentrations of endothelin-1 (et-1) and atrial natriuretic peptide (anp) in 23 patients during the acute phase of ne. they all developed transient renal failure and all displayed characteristics of ne, also verified by a rapid igg antibody test. blood pressure was normal or low in all subjects during the acute phas ...19937900944
[hantavirus infections 1993: endemic or unrecognized pandemic?]. 19937900981
hantavirus disease emerging. 19937901592
a rogues' gallery of hantaviruses. 19937901910
update: hantavirus disease--united states, 1993. 19937902158
[report on detection of rats and humans with hfrs antibody in the faculty of medicine, kyoto university and on measures taken against the trouble]. 19937902816
[distribution of extracellular viral antigen of epidemic hemorrhagic fever in human autopsy cases].using improved immunohistochemical methods, repeated pap and repeated pap + abc, we found in the extracellular spaces of autopsy cases of epidemic hemorrhagic fever large amount of viral antigens. two forms of antigens were found: diffuse soluble antigen and inclusion body like granular antigen. the former was mainly g2 protein and the latter was mainly n protein. they were found in serum, lymph, csf, edema fluid, fluids in renal, seminal tubules, alveolar and bronchial spaces, peptic, intestina ...19937903062
identifying a hantavirus associated with acute respiratory illness: a pcr victory? 19937902477
p53 sweeps through cancer research. 19937903477
hantavirus epidemic in europe, 1993. 19947903744
epizootiological study of hantavirus infection among rattus norvegicus in tokyo bay area, japan.the prevalence of antibodies against hantavirus in 413 rats (rattus norvegicus) captured in eight regions of the tokyo bay area from 1983 to 1992 were examined by the indirect fluorescent antibody test. antibody-positive rats were found in tokyo port in 1983 (34.8%), 1984 (25.9%), 1985 (22.0%) and 1986 (15.6%), in kasai seaside park in 1989 (3.2%) and 1990 (4.2%) and in chiba port in 1990 (6.7%). in tokyo port, antibody-positive rats were found in any season in 1984 and 1985, and seroprevalences ...19937903711
hantavirus epidemic in europe, 1993. 19947903742
hantavirus epidemic in europe, 1993. 19947903743
antibodies to different strains of hantavirus in end-stage renal disease in usa and japan. 19947904033
local host response in the lower respiratory tract in nephropathia epidemica.various lines of evidence suggest a respiratory route of transmission of nephropathia epidemica (ne). to study the response of the respiratory tract in ne, fiberoptic bronchoscopy with bronchoalveolar lavage (bal) was performed in 5 patients in the acute phase of the disease. compared to a reference group of 15 healthy individuals, bal fluid of ne patients contained significantly higher total numbers of cells (p < 0.05) and significantly higher numbers of lysozyme-positive macrophages (p < 0.01) ...19937904380
guillain-barré syndrome associated with hantavirus infection. 19947904032
is "south-west us mystery disease" caused by hantavirus? 19947905062
haemorrhagic fever with renal syndrome. 19937905615
[viral infections--clinical pictures and laboratory diagnosis. part 3: hantaan virus and hantaan-related viruses, hepatitis a and b]. 19937905848
acute hantavirus infection. 19937905899
application of a recombinant baculovirus expressing hantavirus nucleocapsid protein as a diagnostic antigen in ifa test: cross reactivities among 3 serotypes of hantavirus which causes hemorrhagic fever with renal syndrome (hfrs).recombinant baculovirus-infected insect cells which expressed recombinant protein, analogous to the nucleocapsid protein (np) of seoul type hantavirus, strain sr-11 (rnp-sr-sf9) were applied to the indirect immunofluorescent antibody (ifa) test. the rnp-sr-sf9 reacted with anti np mab clones which recognized strain specific or hantavirus common epitopes in the ifa test. the recombinant antigen was detected by antibodies to 3 serotypes of hantaviruses (hantaan 76-118, sr-11, puumala). antibody ti ...19937906956
hantavirus-associated illness identified in north dakota. 19937907617
[atypical pneumonia during hemorrhagic fever with renal syndrome]. 19937907181
[von willebrand factor, antithrombin iii and 5'-nucleotidase in the blood and the athrombogenic properties of the vascular wall in patients with hemorrhagic fever with renal syndrome].willebrand's factor (wf), antithrombin iii (at-iii), blood 5'-nucleotidase and athrombogenic properties of the vascular wall were studied in the course of the disease in 69 patients suffering from hemorrhagic fever with renal syndrome (hfrs). the patients were chiefly under 27 years, had severe or moderate condition. it was found that wf rose 3-fold in oliguria, but returned to normal values by convalescence. at-iii remained stable. high activity of 5'-nucleotidase reached the pick in oliguria a ...19937906437
second international conference on hemorrhagic fever with renal syndrome. 19937908259
retrospective diagnosis of a 1983 case of fatal hantavirus pulmonary syndrome. 19947909065
hantavirus nephropathy in greece. 19947909066
[the level of ionized calcium in the blood and parathyroid function in acute kidney failure in patients with hemorrhagic fever with renal syndrome].in patients with haemorrhagic fever with renal syndrome (hfrs) and in those who had hfrs in the past ionized calcium (ca2+) and parathyroid hormone (pth) levels were measured in the blood. high levels of pth in normal or low those of ca2+ were typical for hfrs oliguria. hyperparathyroidism observed was assessed as an adaptation reaction preventing oliguria-related ca2+ fall. in cured patients neither ca2+ nor pth deviation were reported.19937909180
the domestic cat: a possible transmitter of viruses from rodents to man. 19947908383
hantavirus: an old bug learns new tricks.hantaviruses are a diverse group of rna arboviruses in the bunyaviridae family. although their role as the causative agents of hfrs has been well established, the recent outbreak of a new disease in the southwest clearly demonstrates the protein clinical manifestations that this pathogen can produce. furthermore, whereas hantaviruses have been characterized largely as focal agents in the production of geographically delimited diseases, recent trends indicate that endemic areas for the virus are ...19937907616
renal biopsy findings and clinicopathologic correlations in nephropathia epidemica.a series of 126 adult patients with a serologically confirmed diagnosis of nephropathia epidemica (ne) were studied during the acute phase of the disease. in 86 cases, renal biopsy was performed. the severity of renal failure correlated slightly with blood inflammatory parameters and the degree of hematuria but not with the amount of proteinuria. the degree of hematuria correlated inversely with the level of thrombocytopenia. the most common histopathologic lesion was acute tubulointerstitial ne ...19947910539
antigenic and molecular characterization of hantavirus isolates from china.hemorrhagic fever with renal syndrome (hfrs) is caused by certain viruses in the genus hantavirus, family bunyaviridae, and is a major public health problem in china. by using molecular and serological tests, we characterized 15 hantaviruses isolated either from patients with hfrs or from rodents captured in endemic areas of china. by cross plaque-reduction neutralization tests performed with rabbit immune sera, we identified two serologically distinct groups of viruses, comprised of those relat ...19947909976
epizootiological studies of hantavirus infection among urban rats in hokkaido, japan: evidences for the persistent infection from the sero-epizootiological surveys and antigenic characterizations of hantavirus isolates.epizootiological studies of hantavirus infection among urban rats were carried out through the surveys repeated 11 times at the same dumping ground area in 1983 to 1988. a total of 279 rats (rattus norvegicus) were captured during the surveys. sero-positive animals to hantavirus strain sr-11 were detected in all the surveys. overall positive rate of rats 6 months old or more (94/128, 73.4%) was significantly higher than that of younger rats (23/151, 15.2%, x2 = 96.4, p < 0.001). therefore, age d ...19947911335
[the functional activity of neutrophilic granulocytes in hemorrhagic fever with renal syndrome].in blood samples taken from 33 patients having hemorrhagic fever with the renal syndrome (hfrs) the capacity of neutrophil granulocytes for the ingestion of bacteria and for the reduction of tetrazolium nitro blue, as well as the content of cation protein in the cytoplasm of neutrophils and the concentration of lysozyme in the blood serum of patients, were studied. the study revealed an increase in the values of the above characteristics in comparison with similar data obtained in healthy subjec ...19947910426
rat-transmitted hantavirus disease in sarajevo. 19947912368
clinical quiz. nephropathia epidemica. specific igm antibodies against puumalavirus can be found in serum. 19947912543
in utero and mammary transfer of hantavirus antibody from dams to infant rats.the effects of maternal-infant transfer of specific antibody on infection attributable to hemorrhagic fever with renal syndrome-causing virus in the infant rat were studied. in cross-fostering experiments, maternal hantavirus-specific antibody was shown to be transferred equally effectively to infants either in utero or by breastfeeding. both igg- and iga-specific antibodies were transferred. infected infants that initially acquired high levels of maternal antibodies by either route survived let ...19937908999
hantavirus pulmonary syndrome: kansas, 1993. 19947911857
hantavirus infection. 19947913975
prevalence of serum igg antibodies to puumala virus (haemorrhagic fever with renal syndrome) in northern sweden.a stratified and randomly-selected population sample was identified in 1990 in order to study the seroprevalence of nephropathia epidemica (haemorrhagic fever with renal syndrome) in northern sweden. sera from 1538 subjects (750 men, 788 women), 25-64 years of age, were analysed for the presence of puumala virus (puv) specific-igg by the indirect immunofluorescence antibody test. specific igg was detected in sera from 83 subjects (5.4%). men and women had similar seroprevalence rates. the highes ...19947914872
nephropathia epidemica in finland: a retrospective study of 126 cases.a total of 126 (99 males, 27 females) serologically confirmed hospital-treated adult cases of nephropathia epidemica (ne) were studied. the initial diagnosis suggested by the referring physician was correct in only 28%. some rare clinical manifestations of ne were observed; acute myopericarditis in 3 patients and encephalitis in 1. pulmonary involvement due to vascular congestion was observed in 16% and liver involvement in 34% of the patients. thrombocytopenia was present in 75%, leukocytosis i ...19947910705
virus-related acute renal failure: the clinical course and outcome of hemorrhagic fever with renal syndrome. 19947914707
[hemorrhagic fever with renal syndrome in the structure of natural-focus morbidity in the southern khabarovsk territory and its social significance].according to the data contained in the materials provided by the hospital of infectious diseases of the khabarovsk medical institute, in the recent decade hemorrhagic fever with the renal syndrome, together with pseudotuberculosis, played the leading role in the structure of morbidity caused by natural foci of infections. the distribution of patients in social groups and different important factors of the epidemiology of this disease are considered. taking into account a high morbidity level in ...19937915073
inability of a strain of seoul virus to transmit itself vertically in rats.sr-11 strain of seoul virus was inoculated into new-born female rats. these rats at the age of 13 weeks were mated with uninfected male rats. the virus was transmitted to the male rats, but the offsprings were not infected from their mather rat owing to the maternal antibody. no intrauterine transmission of the virus was observed. we assumed that sr-11 type strain of seoul virus could not be disseminated among rats in nature.19937914245
[the urinary excretion of free amino acids in patients with hemorrhagic fever with renal syndrome].the authors detected impaired urinary excretion of some amino acids in 20 patients suffering from moderate hemorrhagic fever with renal syndrome. the excretory changes depended on the kind of amino acid, the disease period and renal function. the causes of the above abnormality are discussed.19947915862
retrospective and prospective studies of hemorrhagic fever with renal syndrome in rural china.residents of two villages in zhejiang province, china, were interviewed and serum samples were collected to assess prevalence of hantavirus infection. antibody prevalence was 12% (219/1811), with a ratio of illness to infection of 1.0:5.4. seroprevalence increased with age, but no association was found with sex. there was also no evidence of vertical transmission. one year later, 2.3% (30/1325) of seronegative subjects had seroconverted including 2 who had hemorrhagic fever with renal syndrome. ...19947915747
serological evidence of hantavirus disease in northern ireland.since, to our knowledge, no clinically documented cases of haemorrhagic fever with renal syndrome (hfrs) have been reported in northern ireland, a sero-epidemiological study was carried out to assess the degree of hantavirus immunity in a group of 627 northern irish patients presenting with symptoms suggestive of hfrs and 100 healthy controls. ifa screening for igg hantavirus specific antibodies was carried out with a panel of up to 9 different hantaviral antigens. igm screening was performed us ...19947916033
class and subclass distribution of hantavirus-specific serum antibodies at different times after the onset of nephropathia epidemica.sera from dutch and belgium individuals who suffered from nephropathia epidemica (ne), a mild form of haemorrhagic fever with renal syndrome (hfrs), were tested for the distribution of classes and subclasses of hantavirus (hv)-specific antibodies at different times after the onset of the disease, with class- and subclass-specific ig capture enzyme-linked immunosorbent assays (elisas). in the acute, early convalescent, and convalescent phases, predominantly specific iga, igm, and igg3 antibodies ...19947916034
belgrade and hantaan hantaviruses--the causative agents of severe haemorrhagic fever with renal syndrome in children in serbia.during an outbreak of haemorrhagic fever with renal syndrome (hfrs) in 1989, five children (3 girls, 2 boys, aged 6.8-16 years) with a severe form of the disease were treated; four of these were followed for 22-28 months. the main clinical features in all five patients were: fever, headache, myalgia, abdominal and back pain and vomiting; haemorrhagic syndrome was present in four children. renal syndrome presented with severe acute renal failure in all five patients. all patients recovered. serol ...19947917855
detection of muerto canyon virus rna in peripheral blood mononuclear cells from patients with hantavirus pulmonary syndrome.to determine if muerto canyon virus (mcv) rna is present in the peripheral blood of patients with hantavirus pulmonary syndrome, a reverse transcriptase-polymerase chain reaction (rt-pcr) assay for mcv rna was used on blood samples from 20 seropositive case-patients. rna was prepared from peripheral blood mononuclear cells (pbmc) or blood clot (or both) from 19 and from plasma from 11 case-patients. all 12 blood clot, all 13 pbmc, and 8 of 11 plasma preparations produced an mcv amplification pro ...19947930697
rapid differentiation between hantaan and seoul viruses by polymerase chain reaction and restriction enzyme analysis.the majority of causative strains of hemorrhagic fever with renal syndrome (hfrs) are known as hantaan and seoul viruses in korea. the clinical manifestations may be indistinguishable between both viruses, although the clinical course of hantaan virus infection is more severe than that of the seoul virus. therefore, the differentiation of hantaan or seoul virus may be important for predicting the prognosis. the primers were selected from the published sequences of the s segments of hantaan virus ...19947931185
hantavirus infection in the domestic cat. 19947933313
recommendations for hantavirus risk reduction. 19947920364
first reported cases of hantavirus pulmonary syndrome in canada. 19947920363
genetic evidence for a hantavirus enzootic in deer mice (peromyscus maniculatus) captured a decade before the recognition of hantavirus pulmonary syndrome.to determine if the emergence of hantavirus pulmonary syndrome in the united states was a consequence of recent amino-acid altering mutations and/or genetic reassortment with pathogenic hantaviruses, we examined lung and spleen tissues from seropositive deer mice trapped in august 1983 in mono county, california, for hantaviral rna by reverse transcriptase-directed polymerase chain reaction. alignment and comparison of 1485 nucleotides of the s and m genomic segments enzymatically amplified from ...19947941323
hantavirus disease. 19947923452
hantavirus--are we ready? 19947936443
serologic and virologic evidence of a prospect hill-like hantavirus in wisconsin and minnesota.the purposes of this study were to determine if hantaviruses were present in the great lakes port areas of wisconsin and minnesota and if so, to identify which virus and which rodent host species were involved. rodents were trapped in duluth, minnesota, superior, green bay, and milwaukee, wisconsin, all ports of call for international maritime shipping. a total of 675 wild rodents were captured and tested, including 310 meadow voles (microtus pennsylvanicus), 173 norway rats (rattus norvegicus), ...19947943546
isolation of a strain of a hantaan virus from a fatal case of hemorrhagic fever with renal syndrome in slovenia.hemorrhagic fever with renal syndrome (hfrs) has been serologically confirmed in slovenia during the last seven years. there is evidence that three hantaviruses (hantaan, puumala, and a newly described form termed dobrava) circulate simultaneously in this area. recently, a hantavirus was isolated from the urine and brain tissue of a fatal case of hfrs. positive immunofluorescent reactions with reference human sera and monoclonal antibodies were first recognized after the second cell culture pass ...19947943563
hemorrhagic fever with renal syndrome: a study of sequelae following nephropathia epidemica.sequelae following nephropathia epidemica (ne) were investigated in 792 individuals living in an endemic area of sweden. volunteers were tested for presence of puumala (puu) virus specific igg antibodies in serum, as well as several parameters linked with renal dysfunction and cardiovascular disease (systolic and diastolic blood pressure, ecg, bmi, total cholesterol and serum creatinine). no differences were seen in any of the variables tested between puu virus antibody positive (n = 110) and ne ...19947944947
different transmissibility of 2 isolates of seoul virus from the same wild brown rat (rattus norvegicus).two seoul virus strains were isolated from the same wild brown rat (rattus norvegicus) by 2 different procedures. while one isolate (tr-352) by means of a cell culture system had no horizontal transmissibility in 3-week-old rats, another isolate (tr-352r) by means of inoculation to newborn rats had transmissibility in rats.19947948388
association of serine in position 1124 of hantaan virus glycoprotein with virulence in mice.hantaan virus (hv) of the genus hantavirus causes a fatal disease in suckling mice following intraperitoneal or intracerebral infection. hv cl-1, which was obtained from the 76-118 strain of hv by growth in vero e6 cells, exhibited high mortality rates in mice whereas mice infected with hv cl-2 survived without any clinical signs. to determine the molecular basis for the marked difference in virulence, we compared the nucleotide sequences of the large (l), medium (m) and small (s) segments of hv ...19947964639
[hantavirus infection without renal involvement]. 19947938973
comparison of nucleotide sequences of m genome segments among seoul virus strains isolated from eastern asia.the nucleotide sequences of the m genome segments of three seoul virus strains (ki strains) which were isolated from urban rats inhabiting the same enzootic focus between 1983 and 1988 were compared. the viral cdnas were amplified by pcr and were directly sequenced. the nucleotide sequences of ki strains were extremely homologous regardless of isolation year (less than 10 substitutions in 3651 nucleotides, less than 4 substitutions in 1133 amino acids). in addition, the nucleotide sequence of th ...19947941698
hantavirus: an increasing problem?hantaviruses are enveloped rna viruses and members of the bunyaviridae family. they are transmitted from various rodent hosts by inhalation of infected urine, saliva or faeces. infection in rodent hosts is inapparent but persists for life. person-to-person spread of hantavirus has not been described. two main presentations of the disease occur. haemorrhagic fever with renal syndrome (hfrs) is due to hantaan, seoul, puumala, porogia and belgrade viruses. in general hfrs due to hantaan, porogia an ...19947979621
hantavirus disease as a cause for hematuria and acute tubular necrosis? 19947942834
tula virus: a newly detected hantavirus carried by european common voles.a novel hantavirus has been discovered in european common voles, microtus arvalis and microtus rossiaemeridionalis. according to sequencing data for the genomic rna s segment and nucleocapsid protein and data obtained by immunoblotting with a panel of monoclonal antibodies, the virus, designated tula virus, is a distinct novel member of the genus hantavirus. phylogenetic analyses of tula virus indicate that it is most closely related to prospect hill, puumala, and muerto canyon viruses. the resu ...19947966573
hantavirus: an overview and update. 19947983838
isolation of pathogenic hantavirus from white-footed mouse (peromyscus leucopus) 19947984010
hantavirus pulmonary syndrome--virginia, 1993.hantavirus pulmonary syndrome (hps) was first recognized in june 1993 as a result of the investigation of a cluster of fatal cases of adult respiratory distress syndrome (ards) in the southwestern united states (1). during that month, a 61-year-old man was admitted to a hospital in southern pennsylvania with ards; recent testing of all available specimens from this patient has confirmed the diagnosis of hps. this report summarizes the case investigation.19947969008
from the centers for disease control and prevention. hantavirus pulmonary syndrome--virginia, 1993. 19947990229
seoul hantavirus seropositivity among injecting drug users in baltimore. 19947996013
hantavirus. 19948003367
experimental transmission of hantavirus infection in laboratory rats.this study found a competent transmission of hantavirus between cagemates using congenitally t cell-deficient rowett nude rats (rnu/rnu). intraperitoneally infected immunologically normal rats (rnu/+) did not transmit the hantavirus to their normal cagemates (rnu/+) but did to rowett nude rats (rnu/rnu). thus, nude rats were shown to be highly susceptible to the hantavirus infection. also, infected nude rats (rnu/rnu) discharged the infectious viruses, to cause a prevalence of infection among no ...19947996001
serological survey of hantavirus antibodies in chronic hemodialysis patients. 19947994941
genetic identification of a new puumala virus strain causing severe hemorrhagic fever with renal syndrome in germany.a severe case of suspected hemorrhagic fever with renal syndrome (hfrs) was recently identified in northwestern germany. a genetic detection assay was designed that identified hantavirus-specific rna in the patient's clinical specimens by reverse transcriptase-polymerase chain reaction amplification of virus s and m genome segments. phylogenetic analysis of the nucleotide sequences demonstrated that this virus belonged to the puumala (puu) group, with the closest relationship to a puu isolate fr ...19947995985
hantavirus pulmonary syndrome. 19948004332
hantavirus pulmonary syndrome in indiana. 19948034959
hantavirus pulmonary syndrome in new england and europe. 19948041424
hantavirus pulmonary syndrome in new england and europe. 19948041425
quarterly communicable disease review july to september 1993. from the phls communicable disease surveillance centre. 19948037941
hantavirus pulmonary syndrome complicating pregnancy.the purpose of this report is to bring to the attention of obstetric care providers the occurrence in pregnancy of a threatening pulmonary syndrome caused by hantavirus infection.19948059840
isolation of the causative agent of hantavirus pulmonary syndrome.investigation of a recent outbreak of acute respiratory illness in the southwestern united states resulted in the recognition of a new disease, hantavirus pulmonary syndrome (hps) with high mortality. different animals and cell lines were used in attempts to isolate the causative agent. a previously unknown hantavirus was passaged in laboratory-bred deer mice, recovered from lung tissues of a deer mouse, peromyscus maniculatus, and propagated in the e6 clone of vero cells. virus antigen was read ...19948059907
emerging infectious diseases in the united states, 1993.three outbreaks of disease in the united states in 1993 caused by escherichia coli o157:h7, cryptosporidium organisms, and a previously unrecognized hantavirus clearly illustrate the increasing challenges posed by emerging infectious diseases. the largest us outbreak of e. coli o157:h7 infection reported occurred as a result of contaminated hamburgers served at a fast-food restaurant chain. the largest recorded waterborne disease outbreak in us history was due to contamination of a municipal wat ...19948035009
baculovirus expression of the nucleocapsid protein of a puumala serotype hantavirus.recombinant baculoviruses were generated harboring the entire coding region of the s segment cdna of hantavirus strain cg 18-20 that belongs to the puumala serotype. the recombinant nucleocapsid protein was expressed in sf9 cells and shown to be antigenically identical with the authentic viral nucleocapsid protein by means of immunoblot analysis. acute-phase and convalescent sera from european hfrs patients recognized the recombinant nucleocapsid protein in western blots and the recombinant bacu ...19948073635
hantavirus pulmonary syndrome--northeastern united states, 1994.on january 20, 1994, a 22-year-old rhode island man died of acute respiratory distress approximately 5 hours after hospitalization. this report summarizes the case investigation.19948035772
preparing for emerging infections.new infectious diseases continue to emerge, yet there is no clear strategy for managing them. a model response should be devised in the light of past events such as the recent us outbreak of a previously unknown hantavirus.19948047155
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