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new isolates of hfrs virus in sichuan, china and characterisation of antigenic differences by monoclonal antibodies. 19862423827
[isolation of strains of the virus of hemorrhagic fever with renal syndrome in a cell culture from human patients and rodents].the virus of hemorrhagic fever with renal syndrome serologically similar to hantaan virus was isolated from three rodent species, ap. peninsulae, cl. rutilus, cl. rufocanus, and from human patients in vero e6 cell culture.19862425494
some biological properties of virus strains isolated from hemorrhagic fever patients with renal syndrome. 19862879712
[immuno-histochemical study of experimental epidemic hemorrhagic fever]. 19862886229
[clinical features, laboratory data and anti-viral antibody titers in a severe case of hemorrhagic fever with renal syndrome (hfrs)--a one-month course from onset]. 19862877038
ecological and epidemiological data on hantavirus in bank vole populations in belgium.epidemiological and ecological data of a hantavirus infected bank vole population were collected using live-trapping methods. a close association between the distribution of hv-infected bank voles and wet habitat types was found. several seroconversions were observed during the life of individual bank voles. all seroconversions occurred within the wet habitat types and only after a certain age was reached. survival of hv-infected bank voles did not differ from not-infected animals. in the labora ...19862877647
the antigenic analysis of haemorrhagic fever with renal syndrome viruses in china by monoclonal antibodies.thirty-six strains of haemorrhagic fever with renal syndrome (hfrs) virus were isolated from patients and a number of host animals in various areas in china. they were analysed by an immunofluorescence test (ifat) using 10 monoclonal antibodies (mcabs) specific for the hfrs virus; antigenic differences among the strains have been demonstrated. the hfrs virus strains revealed nine different reactions with the mcabs, showing that there are at least nine different antigenic determinants including g ...19862878042
[experimental study on natural infection, biting and transovarial transmission of epidemic haemorrhagic fever virus in gamasid mites]. 19862878731
persistent infection of rats with haemorrhagic fever with renal syndrome virus and their antibody responses.newborn (within 24 h after birth), 1-week-old and 6-week-old (adult) rats were inoculated with a hantaan-related virus (b-1) and attempts were made to isolate the virus from various organs. virus-specific antigens were detected in various organs of newborn rats. moreover virus could be isolated from almost all their organs even 25 weeks after infection. in contrast, in rats infected at 6 weeks of age the virus could be isolated from various organs but its concentration decreased progressively wi ...19862878971
[serological data on hemorrhagic fever with renal syndrome in southeast asia].using an indirect immunofluorescent test with hantaan 76-118 and puumala strains as antigens, antibodies against haemorrhagic fever with renal syndrome viruses were found for the first time in human in laos and viet-nam and confirmed the previously published results in thailand. these results suggest the existence of an hantaan-related virus in these countries.19862879646
[hemorrhagic fever with a renal syndrome]. 19862882632
hantaan virus replication: effects of monensin, tunicamycin and endoglycosidases on the structural glycoproteins.the monovalent ionophore monensin, which interferes with cellular transport pathways, and the antibiotic tunicamycin, which prevents glycosylation of newly synthesized proteins, were used to examine hantaan virus particle formation and polypeptide synthesis. viral replication in the presence of either drug resulted in reduced antigen production as well as reduced yields of both intracellular and extracellular infectious virus. analysis of viral polypeptides synthesized in the presence of the dru ...19863083039
a preliminary report of a comparison of epizootic haemorrhagic disease viruses from australia with others from north america, japan and nigeria. 19863022701
[detection of antibodies to viruses causing hemorrhagic fever associated with a renal syndrome]. 19863089543
[detection of antigens and antibodies of epidemic hemorrhagic fever virus in experimental albino rats in guangzhou city]. 19863091256
antibody to japanese strain of haemorrhagic fever with renal syndrome (hfrs) virus in nigerian sera. 19863111024
[carriers of epidemic hemorrhagic fever virus in rodents and mites in ehf endemic area]. 19863087624
[strains of epidemic hemorrhagic fever virus isolated from the lungs of c. russula and a. squamipes]. 19863100244
coding strategy of the s genome segment of hantaan virus.hantaan virus is the type species of the recently recognized hantavirus genus of bunyaviridae. the small (s) rna segment of the negative-sense, tripartite genome was molecularly cloned and the nucleotide sequence was determined. the rna sequence derived from the cdna copy was found to contain 1696 nucleotides. a single open reading frame of sufficient size to encode the virus nucleocapsid protein was detected in the cdna corresponding to viral complementary-sense rna. rna transcripts of the cdna ...19863024404
[evaluation of the results of a direct solid-phase immunoenzyme method for determining antigens].aspects of an objective analysis of the results of solid-phase enzyme-immunoassay (speia) for identification of antigens (a direct version) were considered on the model of the virus of hemorrhagic fever with renal syndrome. using a statistical method, certain parameters of 11 types of polystyrene and polyvinylchloride microplates (solid carrier) of different manufacturers were studied from the point of view of their suitability for obtaining reproducible speia results. statistical methods for th ...19863099475
propagation of epidemic hemorrhagic fever virus in meriones unguiculatus. 19863100239
[detection of antigens and analysis of antigenicity of hemorrhagic fever with renal syndrome viruses by immune adherence hemagglutination assay (iaha)]. 19862954670
hemorrhagic fever with renal syndrome in czechoslovakia: detection of antigen in small terrestrial mammals and specific serum antibodies in man.a direct elisa technique was used for demonstration of hfrs virus antigen in suspensions of the lungs obtained from 774 wild small mammals belonging to 13 zoological species trapped in 21 localities in czechoslovakia between 1983 and 1984. western serotype of hfrs virus was demonstrated in the lungs of 8 microtus arvalis voles caught in the areas of central bohemia, southern moravia and western slovakia, and in one clethrionomys glareolus vole from the area of eastern slovakia. the eastern serot ...19863084630
[serological demonstration of the presence of hantaan virus in rattus norvegicus rats in a rural environment in france]. 19872951694
[use of monoclonal antibodies for differentiating strains of the virus causing the hemorrhagic fever with renal syndrome].using monoclonal antibody and animal immune sera the experiment confirmed the existence of antigenic relationships between the strains of virus of hemorrhagic fever with renal syndrome (hfrs) isolated in the ussr from clethrionomys glareolus and members of all known serotypes of hfrs virus. clear-cut differentiation was made from serotypes apodemus and rattus, and cross-relationships were shown between the strains isolated in the ussr and prospect hill virus (phv), a member of the serotype micro ...19873124351
viruses of hemorrhagic fever with renal syndrome (hfrs) grouped by immunoprecipitation and hemagglutination inhibition.nine viruses antigenically related to hantaan virus that were isolated from various rodents in several countries and from a patient were examined by immunoprecipitation and by hemagglutination inhibition (hi). the immunoprecipitation tests were done with a monoclonal antibody that reacted with glycoprotein g2 and an antibody against a nucleocapsid protein. the viruses were classified into four subtypes on the basis of the molecular weights of their precipitated polypeptides and the pattern of re ...19873117723
[isolation of strains of the hemorrhagic fever with renal syndrome virus in a cell culture]. 19872977813
serological evidence of hantaan-related viruses in hong kong.sera from rats (rattus norvegicus), domestic animals and man in hong kong were studied by immunofluorescent antibody assay and plaque reduction neutralization tests for evidence of infection by hantaan-related viruses. antibody probably arising from infection by seoul or a seoul-like virus was detected in rat and human sera (and one pig serum), highlighting the potential public health importance of this group of viruses in hong kong, and in the region.19873120366
seroepidemiology of hantaan-related virus in gabon. 19873120374
hantaan virus m rna: coding strategy, nucleotide sequence, and gene order.the m genome segment of hantaan virus was molecularly cloned and the nucleotide sequence of cdna was determined. the virion rna is 3616 bases long with 3'- and 5'-terminal nucleotide sequences complementary for 18 bases. a single long open reading frame in the viral complementary-sense rna had the potential to encode 1135 amino acids or a polypeptide of 126,000 da. amino-terminal sequences of isolated g1 and g2 envelope glycoproteins were determined, revealing a gene order with respect to messag ...19873103329
four serotypes of haemorrhagic fever with renal syndrome viruses identified by polyclonal and monoclonal antibodies.antigenic relationships among 20 strains of haemorrhagic fever with renal syndrome (hfrs) viruses isolated in korea, china, u.s.s.r., finland, japan and u.s.a. were examined with rat immune sera, patient sera, eight monoclonal antibodies against the sr-11 strain and 10 monoclonal antibodies against the 76-118 strain. antigen analyses by indirect immunofluorescent antibody and immune adherence haemagglutination tests using polyclonal and monoclonal antibodies demonstrated that hrfs viruses may be ...19873106565
[transmission of epidemic hemorrhagic fever virus between mice and mites in ehf endemic areas]. 19872898326
enzyme-linked immunosorbent assay for detection of antibody against hemorrhagic fever with renal syndrome virus in sera from experimentally infected rats. 19872892958
[hemorrhagic fever viruses. principal epidemiologic aspects]. 19873038354
[identification of epidemic hemorrhagic fever virus in human leukocytes]. 19873127020
parasites, diseases and health status of sympatric populations of sambar deer and white-tailed deer in florida.from december 1983 to december 1984 a study on parasites, diseases and health status was conducted on sympatric populations of sambar deer (cervus unicolor) and white-tailed deer (odocoileus virginianus) from st. vincent island, franklin county, florida. ten sambar and six white-tailed deer were examined. white-tailed deer had antibodies to epizootic hemorrhagic disease virus and bluetongue virus. serologic tests for antibodies to the etiologic agents of bovine virus diarrhea, infectious bovine ...19873035242
[immunocolloidal gold labelling electron microscopy and its application in studying the morphology of viruses]. 19873036385
[serological demonstration of the presence of hantaan virus in rattus norvegicus rats in an urban environment in france]. 19872951696
[detection of natural foci of the hemorrhagic fever with renal syndrome in the georgian ssr].the circulation of the causative agent of hemorrhagic fever with renal syndrome (hfrs) in georgia was studied. altogether, 7,938 small mammals of 16 species trapped in 23 administrative areas of the republic were examined, and the specific antigen of hfrs virus was detected in 308 (3.8%). in serological examinations of 10 patients, antibody to hfrs virus was found in 4. analysis of the above results indicates the existence of natural foci of hfrs in the georgian ssr.19872893492
[exact determination of the eastern border of the european portion of the nosogeographic range of the hemorrhagic fever with renal syndrome].radioimmunoassay was used for examinations of 21,488 serum specimens from the population of 145 areas of 8 regions and 2 republics. the immune portion comprised 8.8% to the west of the assumed border and 2.7% to the east (t = 20.7). active natural foci of the infection were found in individual territories located to the east of the assumed border (areas of saratov province to the north of the irgiz river, trans-ural areas of bashkiria, southern taiga areas of sverdlovsk, tyumen, and northwestern ...19872893493
nucleotide sequence of the m segment of the genomic rna of hantaan virus 76-118. 19873114716
epizootiology of hantavirus infections in baltimore: isolation of a virus from norway rats, and characteristics of infected rat populations.rats trapped from 14 locations in baltimore, maryland, were shown to have antibody to hantavirus. antibody prevalence rates were higher in residential locations than in parks. infected rats were obtained continuously over a six-year period from 1980-1985 at five locations, indicating the enzootic nature of this infection in urban rats in the united states. prevalence of antibody and geometric mean titers increased with rat mass and sexual maturity, suggesting that infections in rats are acquired ...19873109236
coagulopathy in patients with hemorrhagic fever with renal syndrome.hemorrhagic fever with renal syndrome in korea (korean hemorrhagic fever) is an acute viral disease characterized by fever, hemorrhage and renal failure. in korean patients, the disease manifests more distinctive bleeding tendencies than those of hemorrhagic fever with renal syndrome found in western countries. to investigate the nature and role of the coagulation, fibrinolysis, kinin and immune system in the pathogenesis of such a hemorrhagic manifestation, alterations of these systems were ass ...19873151765
morphology and morphogenesis of viruses of hemorrhagic fever with renal syndrome. ii. inclusion bodies--ultrastructural markers of hantavirus-infected cells.three distinctive types of viral inclusion bodies were identified in hantavirus-infected cells by thin-section electron microscopy. the inclusion bodies, designated granular, granulofilamentous, and filamentous, were intracytoplasmic and closely associated with the rough endoplasmic reticulum and golgi cisternae. virus specificity of the inclusions was verified by immune colloidal gold and immunoperoxidase labeling. the inclusion bodies were a common morphological marker for 13 strains of hantav ...19873610571
[determination of specific immune complexes and dynamics of their circulation in patients with hemorrhagic fever with renal syndrome]. 19872907925
detection of specific serum immunoglobulin m in nephropathia epidemica (scandinavian epidemic nephropathy) by a biotin-avidin-amplified immunofluorescence method.a biotin-avidin-amplified indirect immunofluorescence method was used to demonstrate specific serum immunoglobulin m (igm) antibodies in nephropathia epidemica, the scandinavian type of hemorrhagic fever with renal syndrome. the antigen in the test was the cross-reacting agent of korean hemorrhagic fever, hantaan virus. sixty-two serum samples from 15 patients with clinically typical nephropathia epidemica were analyzed. eleven patients had specific igm in one or more serum samples. the igm coul ...19872885340
[study on the spread of hemorrhagic fever with renal syndrome among animal hosts]. 19872887291
bluetongue and epizootic hemorrhagic disease in white-tailed deer from oklahoma: serologic evaluation and virus isolation.blood samples were collected from 194 white-tailed deer from 27 locations in oklahoma from 1977 through 1984. sixty-eight (35%) of the deer had antibody against bluetongue virus (btv) and 78 (40%) had antibody against epizootic hemorrhagic disease virus. seropositive deer were detected in each of the 4 geographic quadrants of the state. virus isolation was attempted in 40 deer from the northeast quadrant of oklahoma (1983 through 1984); btv was isolated from 11 deer, but epizootic hemorrhagic di ...19872888426
[the first isolation of the hfrs virus from the lung of rattus norvegicus and the blood of patients in jinzhou prefecture]. 19872888536
early diagnosis of hemorrhagic fever with renal syndrome by igm elisa technique. 19872888601
clinical and epidemiological aspects of hemorrhagic fever with renal syndrome (hfrs) in greece.twenty-three cases of hemorrhagic fever with renal syndrome were serologically diagnosed in rural populations of greece between 1982 and 1985. the clinical picture of the disease was severe, (3 deaths recorded among 23 cases) and more closely resembled korean hemorrhagic fever than nephropathia epidemica. examination of patients' sera by indirect immunofluorescence (ifa) assays and plaque reduction neutralization (prnt) tests using hantaan 76-118, puumala, and seoul (urban rat-associated hantaan ...19872888688
cats--source of protection or infection? a case-control study of hemorrhagic fever with renal syndrome.in the first case-control study analyzing risk factors in sporadic hemorrhagic fever with renal syndrome, 111 cases occurring in shanghai in 1983 and 1984 and 136 matched controls were studied. three factors were associated with risk of disease: travel in the month before onset of illness, intense exposure to rodents in the home, and cat ownership. risk associated with cat ownership was not confounded by exposure to rodents in the home. neither cat ownership nor risk associated with rodent expos ...19872889355
zoonotic implications of hantaan-like viruses: an introduction. 19872889843
epidemiology of hantaan and related viruses.hantaan and related viruses, the causative agents of hemorrhagic fever with renal syndrome (hfrs), are significant human pathogens. current epidemiologic evidence indicates that these pathogens are disturbed more widely than once believed, and they are likely to cause disease when man comes into close contact with infected rodents. this report summarizes the characteristics of the hantaanp-related viruses of the genus hantavirus including epidemiology, ecological characteristics, routes of trans ...19872889844
hemorrhagic fever with renal syndrome: mode of transmission to humans.hemorrhagic fever with renal syndrome (hfrs) is a viral disease spread to humans from persistently infected rodents and other small mammals. the consensus of opinion regarding the mechanism of transmission to man indicates a principal role for respiratory infection from aerosols of infectious virus from rodent urine, feces and saliva. interhuman, secondary spread of infection does not occur. the role of ectoparasites in virus transmission is undefined. however, epidemiologic considerations and v ...19872889846
control of laboratory acquired hemorrhagic fever with renal syndrome (hfrs) in japan.by the end of 1985, 126 human cases of laboratory acquired hemorrhagic fever with renal syndrome (hfrs) were recorded in japan. seroepidemiological studies revealed that laboratory rats exhibited high ifa titers against hantaan or related viruses at locations where hfrs patients occurred. laboratory researchers contracted hfrs more frequently than laboratory animal technicians or caretakers, although a laboratory animal caretaker died of the disease. inhalation of hfrs-virus contaminated air in ...19872889847
haemorrhagic fever with renal syndrome involving the liver.a case of haemorrhagic fever with renal syndrome that originated in malaysia is reported. the patient presented with clinical symptoms which were not typical of the disease as seen in endemic regions. renal involvement, which is characteristic of haemorrhagic fever with renal syndrome, was mild, and the predominant symptom was a persistently marked elevation of serum transaminase levels that was suggestive of hepatitis. liver involvement has not been described in the asian form of haemorrhagic f ...19872890086
nephropathia epidemica: incidence of clinical cases and antibody prevalence in an endemic area of sweden.the incidence of nephropathia epidemica (ne) was compared with the ne antibody prevalence in normal population in a highly endemic area of sweden (västerbotten county). the antibody prevalence rate in the oldest age groups were found to be 14 and 20 times higher than the accumulated life-risk of being hospitalized with ne for men and women respectively. whether the infection in persons not admitted to hospital is subclinical, atypical or clinically fulminant, remains to be determined.19872890534
isolation of a hantavirus from a severely ill patient with hemorrhagic fever with renal syndrome in greece. 19872890690
role of t lymphocyte subsets in protection and recovery from hantaan virus infection in mice.adult athymic nude (balb/c background) mice or inbred balb/c mice were inoculated intraperitoneally with hantaan virus (hv), and attempts were made to isolate the virus from brain, lung and spleen. virus was isolated from the organs of balb/c mice for only a short time after infection but was isolated from various organs of nude mice consistently for at least 84 days after infection. viral antigen was also detected in various organs of nude mice for a long time after infection. the effects of ad ...19872885394
[an epidemiologic study on rats associated with outbreak of hemorrhagic fever with renal syndrome--comparison with antibodies for two virus strain, hantaan virus 76-118 strain and newly isolated wkm strain]. 19872890696
[an epidemiologic study on hfrs after six years surveillance--comparison with antibodies for two virus strain, hantaan virus 76-118 strain and wkm strain in members of college]. 19872890697
[detection of foci of hemorrhagic fever with renal syndrome in the estonian ssr].examination by the enzyme-immunoassay of organs of 10 small mammal species trapped in different landscape zones of the estonian ssr revealed the presence of hfrs virus antigen in organs of bank voles and field mice. radioimmunoassay studies of serum specimens from donors demonstrated the presence of antibody to hfrs virus in 2.54% of those examined.19872891222
antibody to hemorrhagic fever with renal syndrome viruses (hantaviruses) in the united states.hantaviruses similar to those which cause hemorrhagic fever with renal syndrome have been isolated from rodents in the united states. serologic evidence suggests that these viruses infect humans. clinical disease has not, however, been associated with infection in the united states. to expand knowledge of the distribution of hantaviruses in the united states and attempt to identify a clinical syndrome associated with infection, a serologic survey was undertaken of us forestry service personnel a ...19872891295
prospective seroepidemiology of hantaviruses and population dynamics of small mammal communities of baltimore, maryland.we used a prospective seroepidemiological study, in conjunction with a mark-release-recapture protocol, to investigate the transmission of hantaviruses in four rodent species from baltimore, maryland, from june 1984 to june 1986. a total of 1,208 captures of 762 rodents provided 984 individual blood samples. the antibody prevalence, as determined by frequency of reciprocal indirect fluorescent antibody (ifa) titers greater than or equal to 32, was 33.9% in rats (rattus norvegicus, n = 466), 28.3 ...19872891308
hantavirus disease. 19872892467
[detection of viral antigens in various organs in 14 fatal cases of epidemic hemorrhagic fever]. 19872892652
[advances in the diagnosis of epidemic hemorrhagic fever]. 19872892653
[experimental study on bitting, trans-stadial and transovarian transmission of epidemic haemorrhagic fever virus by gamasid mites ornithonyssus bacoti]. 19872894898
[acute interstitial nephritis]. 19872885911
partial characterization of a hantavirus isolated from a clethrionomys glareolus captured in belgium.a hantavirus was isolated in vero-e6 cells from lungs of a free living bank vole (clethrionomys glareolus) captured in turnhout, province of antwerp--northern part of belgium. with help of monoclonal antibodies the belgian hantavirus isolate could be clearly differentiated from hantaan virus strain 76-118, prospect hill virus strain ph1 and sr11, a hantavirus isolated from laboratory wistar rat in japan, but not from the nephropathia epidemica virus strain hällnäs.19872886029
detection of hantaviruses with rna probes generated from recombinant dna.radiolabeled rna probes generated from cdna clones of the m and s genome segments of hantaan virus readily detected hantaan virus and two isolates from korean hemorrhagic fever patients but were less effective in detecting four other hantaviruses.19872886113
occurrence and distribution of hantavirus in wild living mammals in belgium.small mammals were screened for the presence of antibodies to hantaan virus (htn) and hantavirus (hv) antigen in belgium. antibody and antigen-positive animals were found in different parts of the country. one insectivore and five rodent species were found positive. the highest prevalence of infection was found in the bank vole (clethrionomys glareolus). a relation between infected animals and wet habitats was observed. it was obvious that in bank vole the likelihood of infection increased with ...19872883857
[hemorrhagic fever with the renal syndrome]. 19872887068
acute hantavirus nephropathy in belgium: preliminary results of a sero-epidemiological study. 19872887093
[hemorrhagic fevers with renal syndrome caused by hantaan virus in france]. 19872892243
epidemiology of nephropathia epidemica in sweden.a comprehensive study of nephropathia epidemica (ne), caused by puumala virus, was conducted in sweden. human sera from residents of various regions of sweden were examined for antibody to puumala virus, and the incidence of ne was determined. small mammals were captured at locations throughout sweden and were examined for antibody to puumala virus and for antigen. the human serosurvey found the highest prevalence rates and the highest incidence rates in northern sweden. the bank vole was found ...19872879874
hantavirus nephropathy, an unrecognized cause of transient acute renal failure in belgium. 19872892329
[hantavirus nephropathy in belgium: description of 2 new cases originating in southern provinces]. 19872892330
[hantavirus nephropathy: apropos of 4 cases diagnosed in south hainaut]. 19872892331
serologic differentiation of virus strains of hemorrhagic fever with renal syndrome (hfrs) by monoclonal antibodies. 19872895468
serological survey of prospect hill virus infection in indigenous wild rodents in the usa.we found serological evidence of infection with prospect hill virus, a hantaan-like virus isolated from meadow voles (microtus pennsylvanicus), in microtine and cricetid rodents trapped in maryland, west virginia, minnesota and california, usa. fluorescent antibodies were detected in sera from m. pennsylvanicus (74/277), m. californicus (39/185), clethrionomys gapperi (5/51), peromyscus maniculatus (4/22) and p. truei (1/11). sera from seropositive p. maniculatus contained neutralizing antibodie ...19872895510
first human case of haemorrhagic fever with renal syndrome in the central african republic. 19872895515
[detection of natural foci of hemorrhagic fever with renal syndrome in the territory of crimean and chernigov provinces]. 19872895547
haemorrhagic fever with renal syndrome: clinical, virological and epidemiological perspectives.haemorrhagic fever with renal syndrome (hfrs) is caused by a group of rna viruses within the family of bunyaviridae known as hantaviruses. the classical, severe form of hfrs is characterized by fever, headache, abdominal and lumbar pain, proteinuria, haemorrhagic phenomena, shock and renal failure. the disease is associated with the prototype hantaan virus and occurs in rural areas of korea and china with apodemus mice as reservoir hosts. a clinically less severe form of hfrs, which is caused by ...19872895603
[persistent infection caused by hemorrhagic fever with renal syndrome virus in bank voles (clethrionomys glareolus)--the natural host of the virus]. 19872907924
[antigenic analysis of hemorrhagic fever with renal syndrome viruses (hfrs) using monoclonal antibodies]. 19872452029
[antigenicity analysis of hemorrhagic fever with renal syndrome viruses by mcabs i]. 19872450686
effects of human and murine interferons against hemorrhagic fever with renal syndrome (hfrs) virus (hantaan virus).the effects of human interferons (ifn-alpha, ifn-beta, ifn-gamma) on the replication of hantaan virus (hv) in vero e6 cells were examined. pretreatment of cells with human ifns resulted in dose-dependent inhibition of hv plaque formation. of the 3 human ifns, ifn-beta inhibited virus replication most effectively. pretreatment of murine macrophage cells with mouse ifn-beta also resulted in an inhibition of viral growth and then the effect of murine ifn-beta in newborn icr mice infected with hv wa ...19872451468
characterization of hantaviruses using monoclonal antibodies.the antigenic relations among nine hantaviruses from seven different geographic areas were examined in indirect fluorescent antibody test with 12 monoclonal antibodies. ten monoclonals were prepared against hantaan virus strain 76-118 and two against hantavirus b-1, a virus isolated from a tumour in a laboratory rat. four different serotypes have been differentiated: hällnäs, hantaan, prospect hill and rat strain like. two monoclonal antibodies were able to react with all nine hantaviruses studi ...19872449811
[antigenic components of the epidemic hemorrhagic fever virus]. 19872443227
[circulation of the virus of hemorrhagic fever with renal syndrome among small mammals in the territory of the ussr].over 55,000 small mammals of 72 species trapped in 62 administrative territories practically in all landscape-geographical zones of the ussr were examined in 1980-1985. the use of current laboratory methods demonstrated a wide spread of hfrs virus in the territory of this country, involvement in the epizootic process of most species of forest and steppe murine rodents and insectivora. in each landscape zone, the main carriers of the hfrs agent were established, represented, as a rule, by the bas ...19872451354
[combined extracorporeal detoxification of the blood and lymphatic drainage in hemorrhagic fever with renal syndrome]. 19872883340
[spreading of the virus of hemorrhagic fever with renal syndrome among small mammals of a meadow-field complex and its epidemiological significance]. 19882901027
detection of the antigen and antibodies to the eastern subtype of haemorrhagic fever with renal syndrome virus in small rodents in slovakia.direct enzyme-linked immunosorbent assay (elisa) was used for the demonstration of haemorrhagic fever with renal syndrome (hfrs) virus antigen in lung tissue of small rodents trapped in eastern and western slovakia. the eastern subtype of hfrs virus antigen was demonstrated in the lungs of apodemus agrarius and of the western subtype in the lungs of microtus arvalis. antibodies to hfrs virus antigen have been detected in apodemus species (a. agrarius and a. flavicollis) in higher titres to the e ...19882899965
conservation of antigenic properties and sequences encoding the envelope proteins of prototype hantaan virus and two virus isolates from korean haemorrhagic fever patients.viruses isolated from the blood of two korean haemorrhagic fever patients were propagated in cell culture and compared to prototype hantaan virus which was isolated from apodemus mice. the antigenic properties of the human isolates were found to be closely related to hantaan virus by plaque reduction neutralization, haemagglutination inhibition and fluorescent antibody staining with both polyclonal and monoclonal antibodies. the medium genome segment of each human isolate was sequenced and compa ...19882900289
hantavirus and leptospira. 19882900396
detection of nephropathia epidemica (puumala virus)-specific immunoglobulin m by enzyme-linked immunosorbent assay.nephropathia epidemica (ne), a less severe form of hemorrhagic fever with renal syndrome, is caused by puumala virus (puu). this communication reports the development of a mu-capture enzyme-linked immunosorbent assay (elisa) for detection of specific immunoglobulin m (igm) antibodies to puu virus in human sera. acute- and early-convalescent-phase sera (collected 1 to 41 days after disease onset) from 29 swedish patients with clinical ne were tested for puu virus-specific igg and igm antibodies b ...19882902106
antigenic relationship between hantaviruses analysed by immunoprecipitation.antigenic relationships between seven hantaviruses isolated in sweden, belgium, korea, european u.s.s.r. and asian u.s.s.r. were studied by radioimmunoprecipitation assays (ripa) and indirect immunofluorescence tests (ift). animal immune sera and haemorrhagic fever with renal syndrome (hfrs) patient sera from the above countries were used. the strains fell into three antigenic groups by both ripa and ift: nephropathia epidemica (ne)-type, korean haemorrhagic fever (khf)-type and urban rat-type. ...19882902191
a simple method of preparing a complement-fixing antigen from the virus of haemorrhagic fever with renal syndrome (western type).different methods of the preparation of haemorrhagic fever with renal syndrome (hfrs) antigen for complement-fixation (cf) test are described. the antigens were prepared from the organs of suckling white rats inoculated with the western type of hrfs by precipitation with polyethylene glycol, by fluorocarbon treatment and or by sucrose-acetone extraction. the highest cf titre was obtained by acetone precipitation of 20% brain suspension in isotonic sucrose.19882902776
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