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immunofluorescence studies of disseminated hantaan virus infection of suckling mice.hantaan virus, the etiological agent of korean hemorrhagic fever, was inoculated intracerebrally or intraperitoneally into suckling mice, and the course of the infection was followed by infectivity titration and immunofluorescence studies. mice became ill and were moribund by 13 to 14 days postinfection. in mice inoculated either intracerebrally or intraperitoneally, virus antigen was present in brain, heart, lungs, liver, and kidney. less consistently, specific fluorescence was observed in sple ...19836134678
isolation of virus causing hemorrhagic fever with renal syndrome (hfrs) through a cell culture system.twenty-three rat lung specimens collected in outbreaks of hemorrhagic fever with renal syndrome (hfrs) in three medical institutions were inoculated onto the vero-e6 cell monolayers. after several blind passages, an agent growing serially in the cell cultures and reacting specifically with known hfrs-positive sera was isolated from two of these specimens. the two isolates were antigenically identical each other. the agent, named strain sr-11, was identified as the causative virus of hfrs by its ...19836134854
haemorrhagic fever with renal syndrome related virus in indigenous wild rodents in belgium. 19836134951
[characteristics of the epizootic process of a natural foci of hemorrhagic fever with renal syndrome in small mammals trapped on the outskirts of ufa]. 19836136899
[immunological and zooparasitological characteristics of epizootics of hemorrhagic fever with renal syndrome in natural foci in the amur river region].in natural foci of hemorrhagic fever with renal syndrome (hfrs) located in agricultural landscapes, rodents of various species are infected with the virus, however, regular hfrs epizootics are observed in field mice which present the highest abundance of infected animals in the population. annually, a high direct correlation is observed between the population density of rodents and the percentage of animals with hfrs virus antigen in the blood and lungs. in 1981, there was a high correlation bet ...19836137110
adaptation to laboratory and wild animals of the haemorrhagic fever with renal syndrome virus present in the foci of european u.s.s.r. brief report.four strains of haemorrhagic fever with renal syndrome virus (hfrsv) from rodents or patients in european u.s.s.r. foci of hfrs were isolated in laboratory bred c. glareolus. the sensitivity of these animals to hfrsv was compared with that of five other laboratory and wild animals.19836138015
[etiology of epidemic hemorrhagic fever]. 19836138158
epidemic hemorrhagic fever with renal syndrome. a broadening horizon.a virus identical to or closely related to the viruses of the epidemic hemorrhagic fevers and/or nephropathia epidemica has been demonstrated serologically in rats from geographically separate areas of this country by three groups of investigators. this information suggests a previously unrecognized health threat that should be considered in the differential diagnosis of patients initially seen with febrile illnesses and acute renal failure. the salient features of these viral diseases and the c ...19836139987
morphological evidence for identifying the viruses of hemorrhagic fever with renal syndrome as candidate members of the bunyaviridae family. brief report.thin section immuno-electron microscopy has been successfully applied to investigate and identify the classical and mild form of hfrs viruses isolated in the people's republic of china. the results showed that all the 8 strains studied (derived from different parts of china, adapted in different cell lines) share a common morphology and morphogenesis. essentially, the viruses possess characteristics of members of the bunyaviridae family, however, differing by a larger size and size variation and ...19836139996
simple procedure for preparation of bluetongue virus and epizootic hemorrhagic disease virus antigens for agar gel immunodiffusion.a simplified procedure was developed for preparing soluble antigen from two related orbiviruses, bluetongue and epizootic hemorrhagic disease viruses, for agar gel immunodiffusion. the antigens gave excellent results in both micro-agar gel diffusion (agar gel precipitin) and macro-agar gel diffusion (bluetongue immunodiffusion). minor modification in the spatial arrangement of reference antisera, commonly utilized in the agar gel immunodiffusion tests, was employed to reduce the possible develop ...19836140269
characterization of hantaan virions, the prototype virus of hemorrhagic fever with renal syndrome.hantaan virus, strain 76-118, was propagated to high titer in a clone of vero cells, and infectious virions were successfully concentrated and purified. infectivity and virus antigenic activity were closely associated with a virus particle that exhibited a sedimentation rate indistinguishable from a representative member of the bunyaviridae. purified virions sedimented to a density of 1.16-1.17 in sucrose and 1.20-1.21 in cesium chloride. detergent disruption of virions resulted in a nucleocapsi ...19836140290
laboratory rat associated outbreak of haemorrhagic fever with renal syndrome due to hantaan-like virus in belgium.hantaan-like virus was identified as the cause of three cases of acute renal failure in staff handling laboratory rats on a belgian university campus. serological studies revealed infected rat strains at different sites on the campus and evidence of past and recent infections in 39 staff members and of infection in 50% of exposed staff. hantaan-reactive antibody was very rare in control populations. staff or rats at three other belgian institutions had no signs of infection. the origin of the vi ...19836140543
diagnosis of epidemic and sporadic interstitial nephritis due to hantaan-like virus in belgium. 19836140577
[stratum of the population of the bashkir assr with natural immunity to hemorrhagic fever with renal syndrome].natural immunity to hemorrhagic fever with the renal syndrome (hfrs) in the human population of the bashkir assr having the highest incidence of this infection was first studied using radioimmunoassay. the antigen was a suspension of lungs of rodents from natural foci containing high antigen titres. when 1726 human sera from 8 districts and 2 towns were examined, antibodies to hfrs were found in 20.1%, with variations from 6.9% to 41.5% in different territories. no relationship between the perce ...19836140792
viruses of classical and mild forms of haemorrhagic fever with renal syndrome isolated in china have similar bunyavirus-like morphology. 19836131283
[hemorrhagic fever with a renal syndrome in the maritime territory].the sporadic character of the occurrence of hemorrhagic fever with the renal syndrome in the primorye territory has been established. three rodent species have been found to be spontaneously infected with the causative agent of this disease. antibodies in patients with this disease are detected at its early stages and persist for a long time after convalescence. the possibility of the formation of a contingent immune to hemorrhagic fever, due to the persons who have had mild and asymptomatic for ...19836132506
etiologic studies of epidemic hemorrhagic fever (hemorrhagic fever with renal syndrome).two strains of epidemic hemorrhagic fever (ehf) virus were isolated from the lung tissues of apodemus agrarius mice that were captured in an area where ehf is endemic. the strains were isolated by passages in a. agrarius mice from a nonendemic area. identification of the isolates by usual procedures was confirmed by repeated blind tests with coded sera. contamination with certain known viruses such as reovirus, adenovirus (types 3 and 7), and other pathogens, such as murine typhus rickettsiae an ...19836132949
[serological studies of convalescent hemorrhagic fever patients with renal syndrome]. 19836133030
hemorrhagic fever with renal syndrome (hfrs). 19826134332
morphological identification of the agent of korean haemorrhagic fever (hantaan virus)as a member of the bunyaviridae.korean haemorrhagic fever (khf) (hantaan virus), a rodent-borne viral illness, is an important cause of human disease throughout much of asia and eastern europe. the agent responsible for khf has not yet been conclusively identified. plaque-purified khf virus was concentrated and then banded in a potassium tartrate gradient. material from the 1.17-1.19 g/ml band was examined by electron microscopy and particles with a morphology identical to that of the family bunyaviridae were found. the partic ...19826121225
taxonomic features of causative agent of haemorrhagic fever with renal syndrome. 19826121241
serotypes of hfrs (haemorrhagic fever with renal syndrome) virus in east european and far eastern u.s.s.r. 19826122096
reovirus type 2 in strains of korean haemorrhagic fever virus. 19826122957
korean hemorrhagic fever. 19826124025
[the research work concerning the prevention and treatment of epidemic hemorrhagic fever in our entire nation (author's transl)]. 19826124371
[a case report which we considered to be the first case of field type korean hemorrhagic fever (khf) in japan and khf antigen in the field mice (author's transl)]. 19826125548
intracerebral inoculation of suckling mice with hantaan virus. 19826125672
hantaan virus is related to hemorrhagic fever with renal syndrome in norway. 19826125745
preliminary evidence that hantaan or a closely related virus is enzootic in domestic rodents. 19826125884
indirect immunofluorescence tests in korean hemorrhagic fever and epidemic (endemic) nephropathia: treatment at low ph for removal of 'nonspecific' fluorescence in tissues from immunocompetent hosts.a 'nonspecific' fluorescence probably caused by immunocomplexes appears in the lung tissue of immunocompetent hosts infected with korean hemorrhagic fever (khf) or epidemic nephropathy (en) viruses. indirect immunofluorescence tests with such khf- or en-infected tissue as antigen are unsatisfactory for the detection of low-titer antibody or the reading of titer endpoints. treatment of acetone-fixed lung sections at ph 3.0 followed by washing with 0.01 m phosphate-buffered saline and distilled wa ...19826126464
isolation of hantaan virus, the etiologic agent of korean hemorrhagic fever, from wild urban rats.urban rats captured in seoul and four nearby korean cities were found to have immunofluorescent antibodies reactive with hantaan virus, the etiologic agent of korean hemorrhagic fever (khf). serum antibodies were detected in 13% from 477 rattus norvegicus and 11% of 47 rattus rattus. hantaan viral antigen was found in pulmonary tissues of 42 animals, and hantaan virus was recovered from 23 rats, all but two of which were r. norvegicus. wistar rats were qualitatively much more sensitive than apod ...19826127366
laboratory-acquired infections with hantaan virus, the etiologic agent of korean hemorrhagic fever.clinically apparent infections with hantaan virus, the etiologic agent of korean hemorrhagic fever, occurred in nine persons exposed to the virus at the korea university virus institute (seoul) between 1971 and 1979. all were directly related to trapping of wild rodents or work with naturally or experimentally infected wild and laboratory rodents in a designated animal suite. all infections were acquired during the months of november-april, and none was associated with accidental parenteral inoc ...19826127367
[etiological studies of epidemic hemorrhagic fever. i. virus isolation in apodemus agrarius from non-endemic area and its antigenic characterization]. 19826128079
epidemic hemorrhagic fever revisited.epidemic hemorrhagic fever is a disease characterized by phases of sequential fever, hypotension, oliguria, and polyuria. this disease represented a major hazard for american soldiers during the korean war (1950-1953) and is a persistent problem in asia, the ussr, and northern europe. advances in the etiology, epidemiology, and therapy of epidemic hemorrhagic fever are discussed.19826128779
new hemorrhagic fever with renal syndrome-related virus in rodents in the united states. 19826129495
other serotypes of hemorrhagic fever with renal syndrome viruses in europe. 19826129496
seroepidemiology of hantaan virus. 19826129497
serological diagnosis of hemorrhagic fever with renal syndrome in european region of u.s.s.r. 19826129499
hemorrhagic fever with renal syndrome in finland: ecology and virology of nephropathia epidemica. 19826134333
clinical features of hfrs in scandinavia as compared with east asia. 19826134335
muroid virus nephropathies and muroid viruses of the hantaan virus group.hemorrhagic fever with renal syndrome (hfrs) came dramatically to the attention of western medicine in 1951 with the "new" disease becoming a major source of morbidity and mortality in american troops in korea. known there as epidemic hemorrhagic fever (ehf) or korean hemorrhagic fever (khf), it became apparent that it was the same disease as the endemic (epidemic) hemorrhagic nephroso-nephritis of the soviet far east and songo fever of the japanese army in manchuria. the conjecture that the mil ...19826134336
[etiological research on a mild type of hemorrhagic fever]. 19826136336
[advances in researches on the problem of etiology and sero-epidemiology of epidemic hemorrhagic fever]. 19826136339
[propagation and characterization of the etiologic agent of epidemic hemorrhagic fever in cultured a-549 cells]. 19826216011
hfrs antigen and antibody in two species of swedish voles. 19826819638
antigenic differences between european and east asian strains of hfrs virus. 19826820724
[study of apodemus (agrarius) as a host of epidemic hemorrhagic fever virus and application of apodemus lung antigen for laboratory diagnosis]. 19826192929
observations on natural and laboratory infection of rodents with the etiologic agent of korean hemorrhagic fever.studies were conducted to define the natural host range of the korean hemorrhagic fever (khf) agent in south korea, and to identify colonized rodents susceptible to this infection. eight species of field rodents were captured in areas of korea endemic for khf and their tissues were examined by immunofluorescence for the presence of khf antigen. one hundred and fourteen of 817 apodemus agrarius coreae captured between 1974 and 1978 had one or more positive organs. no positive organ was found in 2 ...19816786119
serum antibodies reactant with korean haemorrhagic fever agent in scandinavian epidemic (endemic) nephropathy (nephropathia epidemica) demonstrated by immunofluorescence utilizing an in vitro antigen source.a newly developed spot slide immunofluorescence method utilizing an in vitro antigen source was used for the first time for the assay of antibodies reactant with the korean haemorrhagic fever (khf) agent in sera from patients diagnosed with scandinavian epidemic (endemic) nephropathy (nephropathia epidemica, ne) and from age-matched control patients living in the same area as the ne patients but suffering from other diseases. khf antibodies were demonstrated in all of 14 ne patients who were fol ...19816797053
antigenic difference between european and east asian viruses causing haemorrhagic fever with renal syndrome. 19816166823
detection by enzyme-linked immunosorbent assay of haemorrhagic fever with renal syndrome virus in lung tissue of rodents from european u.s.s.r. 19816112426
electron microscope appearance of hantaan virus, the causative agent of korean haemorrhagic fever.the morphology and morphogenesis of three strains of hantaan virus, which causes korean haemorrhagic fever (khf), were examined by thin-section and negative-contrast electron microscopy of infected a549 cell-culture specimens. in thin sections, virus was detected within cytoplasmic granular matrices (viroplasms) of the infected cells. virus particles were spherical (diameter 73 +/- 5 nm), and had an extremely electron-dense core (diameter 47 +/- 6.5 nm). replication and maturation of the virus s ...19816112446
[demonstration of the virus of hemorrhagic fever with renal syndrome in the organs of rodents from natural foci of the infection in the ussr and the serodiagnosis of the diseases].an indirect fluorescent antibody test (ifat) and an enzyme-immunological test (elisa) were used for the detection of hfrs virus in organs of rodents from hfrs foci in the ussr. the virus was found in 115 out of 1120 bank voles, 9 out of 92 redbacked voles, and 2 field voles examined. spontaneous infection-rate of bank voles in population varied from 1.3 to 100% correlating with the epidemiological situation in foci. ifat and elisa were successfully used for serodiagnosis of hfrs. examinations of ...19816121425
korean hemorrhagic fever: propagation of the etiologic agent in a cell line of human origin.the etiologic agent of korean hemorrhagic fever has been propagated in a human cultured cell line derived from a carcinoma of the lung. the cells, described as type ii, alveolar epithelial, support replication of the agent and successive passages. antigen of the korean hemorrhagic fever agent is readily detected in infected cells by means of direct or indirect fluorescent antibody techniques. previous attempts to propagate this agent in vitro had been unsuccessful.19816110243
propagation of korean hemorrhagic fever virus in laboratory rats.korean hemorrhagic fever virus (khfv) has been adapted to the wistar and fisher strains of rats. infection was detected by the appearance of specific antigen in the lung tissue of the infected rats at 14 to 64 days after inoculation and by the appearance of circulating antibodies in ther serum which reacted specifically with khfv antigen in the lungs of infected apodemus agrarius subsp. coreae 3 weeks after inoculation. distribution of antigen in rat tissues as determined by immunofluorescent st ...19816111538
serological evidence for korean haemorrhagic fever in greece. 19816111686
[detection of the etiologic agent of hemorrhagic fever with a renal syndrome in the lungs of wild rodents].the results of the studies on wild rodents trapped in the areas of the leningrad region visits to which were associated with human cases of hemorrhagic fever with renal syndrome (hfrs) are presented. in one of these areas 30% of bank voles were found to be infected. specific fluorescence of high intensity was found in ctyostat sections of lungs from bank voles treated by the indirect fluorescent antibody procedure. fluorescent granules, their clumps and large conglomerates were localized in the ...19816115516
intraspecific transmission of hantaan virus, etiologic agent of korean hemorrhagic fever, in the rodent apodemus agrarius.experimental parameters of infection and intraspecific transmission of hantaan virus, the etiologic agent of korean hemorrhagic fever, in apodemus agrarius rodents were determined. mice inoculated by the intramuscular route experienced viremia for about 1 week beginning on day 7. after 3 weeks, immunofluorescent and neutralizing antibodies were present and no mouse ever developed signs of acute illness. virus was recovered from lung, kidney, salivary gland, and liver, and virus excretion in urin ...19816116436
detection of hemorrhagic fever with renal syndrome (hfrs) virus in the lungs of bank voles clethrionomys glareolus and redbacked voles clethrionomys rutilus trapped in hfrs foci in the european part of u.s.s.r., and serodiagnosis of this infection in man.the antigen of hfrs virus was demonstrated by means of the indirect fluorescent antibody procedure in the lung tissue of bank and redbacked voles (clethrionomys glareolus, cl. rutilus) trapped in hfrs foci in the european part of ussr. this antigen has been used satisfactorily for serodiagnosis of hfrs in several european and asian regions of the ussr where hfrs had been found to be endemic.19816117265
korean hemorrhagic fever among rural residents in japan.naturally occurring infection with korean hemorrhagic fever virus among four families living in rural areas of northern and central japan was proved by the demonstration of antibody to the virus. furthermore, korean hemorrhagic fever virus antigen was detected in the lung tissues of wild rodents captured in the endemic area. these findings indicate the endemic presence of korean hemorrhagic fever virus on honshu island, japan.19816118386
[sbl test in the serologic diagnosis of epidemic nephropathy]. 19816119409
[laboratory diagnosis of hemorrhagic fever with renal syndrome (a review)]. 19806121396
[probable routes of the cycle in the nature of the causative agent of hemorrhagic fever with renal syndrome]. 19806121397
aetiological relation between korean haemorrhagic fever with renal syndrome in people's republic of china. 19806102694
identification of epidemic haemorrhagic fever with renal syndrome in china with korean haemorrhagic fever. 19806103345
scandinavian epidemic nephropathy and korean haemorrhagic fever. 19806105239
antigenic differentiation of the viruses causing korean haemorrhagic fever and epidemic (endemic) nephropathy of scandinavia. 19806105459
are there two serotypes of the agent of haemorrhagic fever with renal syndrome? 19806106800
exotic viral diseases.marburg virus disease, lassa fever, monkeypox, and ebola virus diseases of humans have all been recognized since 1967. these are examples of some of the exotic virus diseases which through importation may present a potential public health problem in the united states. some of these viruses are also highly hazardous to laboratory and medical personnel. this paper is a review of the general characteristics, the epidemiology, and laboratory diagnosis of the exotic viruses which have been described ...19806246685
[observation on the therapeutic effect of endoxen (cyclophosphamide) in the treatment of epidemic hemorrhagic fever and an investigation of its pathogenesis (author's transl)]. 197945177
aetiological relation between korean haemorrhagic fever and nephropathia epidemica.a close aetiological relation between korean haemorrhagic fever and nephropathia epidemica of scandinavia has often been suggested because of similarities in their clinical picture and epidemiology. this relation has now been confirmed serologically; raised titres of antibody to korean haemorrhagic fever agent and seroconversions have been found by the indirect fluorescent-antibody technique in 20 patients with nephropathia epidemica.197984207
korean haemorrhagic fever in staff in an animal laboratory.in march, 1975, and january, 1978, there were outbreaks of korean haemorrhagic fever (k.h.f.) among staff in the animal laboratory of the clinical research building of tohoku university hospital. 13 doctors and 1 veterinarian had k.h.f., and all except 1 had a mild but typical clinical course. k.h.f. antibody titres were significantly raised in all 14 patients. 12 other doctors working in the same room had no symptoms and no k.h.f. antibody. k.h.f. antibody was also detected in 3 animal technici ...197987777
epidemic nephropathy in scandinavia is related to korean haemorrhagic fever. 197984099
etiological relation between korean hemorrhagic fever and epidemic hemorrhagic fever in japan.the first case of epidemic hemorrhagic fever in japan was seen in osaka in 1960. the etiologic agent of this disease has not yet been isolated, but a close etiologic relation between korean hemorrhagic fever and epidemic hemorrhagic fever in japan has been suspected because of similarities in the clinical and pathological pictures of the two diseases. this relation has now been confirmed serologically by demonstrating specific immunofluorescent antibodies to korean hemorrhagic fever virus in 19 ...197943726
[korean hemorrhagic fever (author's transl)]. 197938978
antigenic relationship of two strains of simian hemorrhagic fever virus.serological comparison of the prototype and an epizootic (corbell) strain of simian hemorrhagic fever virus revealed that the two viruses were serologically similar. the prototype strain differs from the corbell strain in that the latter cannot be cultivated in vitro. serological comparison of the prototype virus grown in tissue culture and its homologous antibody and the prototype and corbell viruses recovered from rhesus monkey serum and their homologous antibodies showed differences and sugge ...1978100652
[methodical studies on virus isolation in experimental viral hemorrhagic septicemia (vhs) of the trout]. 1977411480
an emerging zoonosis in scandinavia -- nephropathia epidemica.the paper reviews as zoonosis the disease called nephropathia epidemica in north european countries. the etiology is as yet unsolved but a viral one is highly suspected with small rodents (voles and mice) as the source of infection. based on the epidemiological peculiarities of the disease, the ecology of the agent and hypothetical ways of transmission of infection from small rodents to man are discussed.197720600
isolation and partial characterisation of a new virus causing acute haemorrhagic fever in zaire. 197765661
failure to prove arenavirus infection among the small mammals from an endemic area of korean hemorrhagic nephrosonephritis.in the light of recent knowledge on a complex of diseases caused by a new group of viruses, arenaviruses, virological studies largely directed toward small field mammals were undertaken during 1973-1974 aiming at etiological clarification of korean hemorrhagic nephrosonephritis (khnn). specimens were collected in an endemic area of khnn located north to northeast of seoul. virus isolation tests with 299 urine specimens and 131 mite pools recovered from small mammals and 14 acute stage sera from ...197612383
the rnas of the defective interfering pichinide virus.a pichinde persitently infected bhk21/13s culture was established in which defective interfering (di) virus continued to be synthesized after cessation of plaque-forming virus replication. this di virus, concentrated from nacl-polyethylene glycol treated tissue culture fluids, was shown to band over a much broader range than standard virus, in either discontinuous or continuous sucrose gradients. the polyacrylamide gel profile of the rnas extracted from standard virus contained six components wi ...1976819626
a serologic survey of pronghorns in alberta and saskatchewan, 1970-1972.to determine the exposure of free-ranging pronghorns (antilocapra americana ord) to selected pathogens, serum samples were obtained from 33 live-trapped animals from southwestern saskatchewan in 1970, and from 26 and 51 animals from southeastern alberta, in 1971 and 1972, respectively. antibodies were found to the agents of parainfluenza 3, bovine virus diarrhea, eastern and western encephalomyelitis, infectious bovine rhinotracheitis and the chlamydial group. no serologic reactors were found to ...1975167203
bluetongue-like disease of deer.a comparison has been made of the disease produced in white-tailed deer by the viruses of epizootic haemorrhagic disease and bluetongue. the similar nature of these diseases in deer and of some of the viral properties has been described. although these two viruses are considered to be distinct, it is possible by employing an unnatural procedure to produce antibody which will demonstrate a minor antigenic component common to both viruses. biological features that differ between the two viruses ha ...1975169787
[incidence of antibodies to crimean haemorrhagic fever in animals (author's transl)]. 1975803341
immunosuppression by junin virus. ultrastructural study. 19744213176
[indirect hemagglutination reaction with chf-congo group viruses]. 19744217050
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