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hantaan virus replication: effects of monensin, tunicamycin and endoglycosidases on the structural glycoproteins.the monovalent ionophore monensin, which interferes with cellular transport pathways, and the antibiotic tunicamycin, which prevents glycosylation of newly synthesized proteins, were used to examine hantaan virus particle formation and polypeptide synthesis. viral replication in the presence of either drug resulted in reduced antigen production as well as reduced yields of both intracellular and extracellular infectious virus. analysis of viral polypeptides synthesized in the presence of the dru ...19863083039
hemorrhagic fever with renal syndrome in czechoslovakia: detection of antigen in small terrestrial mammals and specific serum antibodies in man.a direct elisa technique was used for demonstration of hfrs virus antigen in suspensions of the lungs obtained from 774 wild small mammals belonging to 13 zoological species trapped in 21 localities in czechoslovakia between 1983 and 1984. western serotype of hfrs virus was demonstrated in the lungs of 8 microtus arvalis voles caught in the areas of central bohemia, southern moravia and western slovakia, and in one clethrionomys glareolus vole from the area of eastern slovakia. the eastern serot ...19863084630
coding strategy of the s genome segment of hantaan virus.hantaan virus is the type species of the recently recognized hantavirus genus of bunyaviridae. the small (s) rna segment of the negative-sense, tripartite genome was molecularly cloned and the nucleotide sequence was determined. the rna sequence derived from the cdna copy was found to contain 1696 nucleotides. a single open reading frame of sufficient size to encode the virus nucleocapsid protein was detected in the cdna corresponding to viral complementary-sense rna. rna transcripts of the cdna ...19863024404
[detection of antibodies to viruses causing hemorrhagic fever associated with a renal syndrome]. 19863089543
[carriers of epidemic hemorrhagic fever virus in rodents and mites in ehf endemic area]. 19863087624
[detection of antigens and antibodies of epidemic hemorrhagic fever virus in experimental albino rats in guangzhou city]. 19863091256
antibody to japanese strain of haemorrhagic fever with renal syndrome (hfrs) virus in nigerian sera. 19863111024
definition of three serotypes of hantaviruses by a double sandwich elisa with biotin-avidin amplification system.a total of seven different isolates of hantaviruses from five mammalian species and six geographical areas were examined by a double sandwich elisa with biotin-avidin amplification system. three serotypes were recognized by comparing antigen titres to homologous and heterologous antibody and blocking antibody titres to homologous and heterologous antigens. serotype 1 included four strains: hantaan virus isolated from apodemus agrarius in south korea, hupei-i isolated from acute-phase serum from ...19853926952
partial characterization of prospect hill virus isolated from meadow voles in the united states. 19853930622
certified cell lines of rat origin appear free of infection with hantavirus. 19853930626
serologic evidence of hantaan-like virus in rodents and man in thailand.a serologic survey was conducted to determine the presence of antibody to hantavirus in rodents in thailand. sera from over 300 rodents were tested by an immunofluorescent antibody method. bandicota indica, a field rodent, was found to have a high incidence of infection (20-24%) in 2 locations. a hantavirus was isolated from lung samples of b. indica. when sera were tested from humans living in kanchanaburi and several locations in bangkok, those people living in close proximity to the infected ...19853938073
isolation of haemorrhagic fever with renal syndrome virus from leukocytes of rats and virus replication in cultures of rat and human macrophages.newborn rats were inoculated intraperitoneally with haemorrhagic fever with renal syndrome (hfrs)-related virus (b-1 strain), and virus isolation from their various organs was attempted between 1 and 25 weeks after inoculation. virus could be isolated repeatedly from lung, brain, spleen and kidney and also from peripheral blood. when virus isolation was carried out on fractionated peripheral blood cells, virus was associated mainly with the macrophage fraction and to a lesser extent with granulo ...19853925075
reservoir animals for nephropathia epidemica in norway: indications of a major role for the bank vole (c. glareolus) in comparison with the woodmouse (a. sylvaticus).small rodents were collected live in two different locations within a nephropathia epidemica (ne) endemic area, and tested for both antiviral serum antibodies and viral antigens in lung sections. in one location, only apodemus sylvaticus (woodmice) were found in the traps, in the other, both a. sylvaticus and clethrionomys glareolus (bank voles) were collected. among the woodmice from the former location the prevalence of ne virus markers was significantly lower than for either woodmice or bank ...19853919085
outbreak of haemorrhagic fever with renal syndrome in greece.an outbreak of eight cases of haemorrhagic fever with renal syndrome in north-west greece is presented. the major clinical manifestation was fever and all patients subsequently developed decreased renal function and proteinuria. the disease was diagnosed by rising antibody titers to the hantaan virus.19852861091
hantaan virus. 19852861238
serological and virological evidence of a hantaan virus-related enzootic in the united states.the first isolation of a hantaan-related virus from a feral rat in the united states was made from a rattus norvegicus caught in new orleans. the strain, designated tchoupitoulas virus, is antigenically related to, but distinct from, the prototype strain 76-118 of hantaan virus and is the first hantaan-like virus isolated from the pancreas of a naturally infected animal. serosurveys of wild rodents from urban and rural areas in the united states indicated that hantaan-related viruses infected ur ...19852861241
experimental infection with puumala virus, the etiologic agent of nephropathia epidemica, in bank voles (clethrionomys glareolus).subclinical chronic infections characterized by transient viremia, prolonged virus shedding in oropharyngeal secretions and feces, and virus persistence in tissues (particularly lung) developed in laboratory-bred weanling bank voles (clethrionomys glareolus) inoculated intramuscularly with puumala virus (strain hällnäs), the etiologic agent of nephropathia epidemica. viral antigen, as evidence by granular fluorescence, was detected in the lungs, liver, spleen, pancreas, salivary glands, and smal ...19852861296
[hantaan viruses. pathogenic agents in zoonoses]. 19852861673
[morphological study of two strains of hemorrhagic fever renal syndrome virus isolated from patients]. 19852861905
isolation of a hantaan-related virus from brazilian rats and serologic evidence of its widespread distribution in south america.a serosurvey of domestic rats was conducted in several south american cities between september 1982 and march 1983 for evidence of hantavirus infection. antibody-positive rats were found in belem, são paulo and recife-olinda, brazil and in buenos aires, argentina, with the highest antibody prevalence rate detected in belem (30 positive of 54 tested, 56%). a virus isolated from tissues of a rattus norvegicus captured in belem, was shown to be antigenically similar to girard point viruses isolated ...19852862803
[epidemiological study of epidemic hemorrhagic fever in china]. 19852862996
[main reservoirs of infection of the hemorrhagic fever renal syndrome in endemic areas of anhui province]. 19852862997
[relationship between hosts and hemorrhagic fever renal syndrome in chang-an county, shan-xi province]. 19852862998
a scottish case of nephropathy due to hantaan virus infection.an illness characterised by acute renal failure, fever, conjunctivitis and a macular erythematous centrifugal rash is described in a scot who had not recently travelled abroad. there was serological evidence that the illness was due to hantaan or a closely related virus.19852863308
differential susceptibility and resistance of immunocompetent and immunodeficient mice to fatal hantaan virus infection.susceptibility and resistance to fatal hantaan virus meningoencephalitis were studied in immunocompetent (nu/+) and congenitally t-cell deficient (nu/nu) cd-1 mice of different ages. susceptibility of nu/+ mice to fatal infection was age-dependent, as evidenced by 100 percent mortality in mice inoculated intracerebrally with hantaan virus (strain 76-118) during the first week of life, 60 percent mortality in mice inoculated at 9 days of age, and no disease or death in mice inoculated at 14 to 42 ...19852864037
[detection of natural foci of hemorrhagic fever with renal syndrome on the territory of the komi assr].natural foci of hemorrhagic fever with the renal syndrome (hfrs) have been found for the first time in the komi assr. the main source of the causative agent in this territory was clethrionomys glareolus the average infection rate of which was 4.4% and in some areas as high as 22.6%. for the first time in the republic the portion of human population naturally immune to hfrs was determined, comprising 5.2% of the population. the immune structure of the population did not differ from that in other ...19852864760
antiviral neutralizing antibody to hantaan virus as determined by plaque reduction technique.the 76--118 strain of hantaan virus was titrated in e6 (vero) cells by the plaque method using agarose overlay medium. visible plaques, formed 10 days post-infection, were uniformly 2--3 mm in diameter. dose-response experiments showed that a single infectious particle initiated the formation of a plaque. infectivity titers by the plaque method were equivalent to those obtained by the endpoint method (tcid50) using the immunofluorescence antibody technique (ifa) for antigen detection. the single ...19852859845
[cases of hemorrhagic fever renal syndrome in 3 counties of the guang xi zhuang tribe autonomous region for the first time with the recovery of hemorrhagic fever viral agents from infected rodents]. 19852859926
[hemorrhagic fever with renal syndrome in penza province].the evidence of the existence of natural foci of hfrs in penza region has first been presented on the basis of serological examinations of patients and normal population as well as hfrs virus antigen demonstration in the lung tissue of small mammals. an outbreak of hfrs among children in a pioneer camp is described. aerogenic infection of the children contracted from hfrs virus-infected bank voles (clethrionomys glareolus) living near the camp is assumed. the detection of hfrs antigen in 5 speci ...19852860753
pathogenesis of hantaan virus infection in suckling mice: clinical, virologic, and serologic observations.hemorrhagic fever with renal syndrome (hfrs) is a debilitating disease of humans caused by hantaan virus (hv), the prototype member of a newly proposed genus of bunyaviridae. studies of hv pathogenesis have been limited by the absence of a well defined model for a virus-induced disease state. in an attempt to devise a model for hv pathogenesis in laboratory rodents, newborn outbred suckling icr mice were shown to be uniformly susceptible to lethal infection with non-mouse adapted hv by intracere ...19852858987
serological evidence of hantaan virus infection in the united states.we found low titers of fluorescent antibodies against hantaan virus, the etiologic agent of korean hemorrhagic fever, in sera from 7 of 1,035 patients with febrile illnesses of unknown origin and from 6 of 664 blood donors in the united states. all but 1 of these individuals possessed neutralizing antibodies against hantaan virus. this was a 31-year-old research technician who had worked with laboratory rodents with virus-induced tumors, but had not traveled abroad, suggesting that infection wit ...19852858988
hantaan virus infection in suckling mice: virologic and pathologic correlates.the hantaan virus suckling mouse model was examined to delineate virologic and histopathologic characteristics of infection at the organ level. viral antigen and infectious virus were detected in all organs examined, with highest titers achieved in brain, lung, and kidney. a constellation of histologic lesions was identified in brain (diffuse meningoencephalitis with bilaterally symmetrical thalamic necrosis), liver (pericholangiohepatitis), lung (pneumonitis), and spleen (lymphoid hyperplasia); ...19852865331
[characteristics of the epizootic process in hemorrhagic fever with renal syndrome].for the first time in the study of epizootology of hemorrhagic fever with the renal syndrome (hfrs) in wild animals data are presented indicating certain relationship between true infection rate of bank voles with hfrs virus and the content of the circulating antigen of hfrs virus and antibody to this virus in these animals. different age groups of animal populations were shown to have different intensity of immunity: it was more marked in animals of older age groups, and less in young animals. ...19852865854
[seroepidemiology of hemorrhagic fever with renal syndrome (hfrs) virus in fukuoka]. 19852866153
serotypic classification of hantaviruses by indirect immunofluorescent antibody and plaque reduction neutralization tests.antisera prepared against 16 strains of hantaviruses isolated from patients with hemorrhagic fever with renal syndrome (hfrs) or from rodents captured in hfrs-endemic and nonendemic regions were titrated against hantaan virus strain 76-118, puumala virus strain sotkamo, and prospect hill virus strain prospect hill-i by using the indirect immunofluorescent antibody and plaque reduction neutralization tests. isolates fell into one of four distinct groups or serotypes. serotype 1 included apodemus- ...19852866197
[hemorrhagic fever with renal syndrome caused by puumala virus. 2 cases with hypertriglyceridemia in the aube department]. 19852866508
efficacy, toxicology and clinical applications of ribavirin against virulent rna viral infections. 19852867737
[the domestic cat as the host animal of the epidemic hemorrhagic fever virus]. 19852870786
isolation of haemorrhagic fever with renal syndrome virus from suncus murinus, an insectivore. 19852857871
epidemiological study of hemorrhagic fever with renal syndrome related virus infection among urban rats in two islands in tokyo bay, japan.a seroepidemiological survey of hemorrhagic fever with renal syndrome (hfrs) virus infection in 403 urban rats (rattus norvegicus) captured on two different islands in tokyo bay was carried out using the indirect immunofluorescent antibody (ifa) test with the sr-11 strain of hfrs virus. antibody positive sera were detected in 99 out of 355 (27.9%) rats from the island with reclaimed ground area, but none were detected in 48 rats from the other islands. ifa titers of the positive sera varied from ...19852859764
antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome.hemorrhagic fever with renal syndrome (hfrs) comprises a variety of clinically similar diseases of viral etiology that are endemic to and sporadically epidemic throughout the eurasian continent and japan. although hfrs has not been reported in north america, viruses that are antigenically similar to hfrs agents were recently isolated from rodents in the united states. examination and comparison of eight representative isolates from endemic disease areas and from regions with no known associated ...19852858126
immune spleen cell-mediated protection against fatal hantaan virus infection in infant mice.to clarify the basis of the age-dependent susceptibility of infant mice to fatal meningoencephalitis caused by hantaan virus, we investigated the ability of spleen cells from immune and nonimmune weanling balb/c mice to confer protection to syngeneic infant mice. intraperitoneal transfer of 10 x 10(7), 5 x 10(7), 2.5 x 10(7), and 1.2 x 10(7) immune spleen cells to infant mice 24 hr after intracerebral challenge with 100 50% lethal doses of hantaan virus (strain 76-118) resulted in 100%, 70%, 64% ...19852857753
[reservoirs of the causative agent of hemorrhagic fever with renal syndrome in maritime territory foci].examinations of 6362 small mammals of 18 species revealed the main reservoirs of the causative agent of hemorrhagic fever with the renal syndrome (hfrs) in foci of the primorsky krai, and demonstrated the importance of individual species in the epidemiology of the infection. data on the circulation in the region of antigenically different serotypes of hfrs virus are presented.19852408384
distinction between bunyaviridae genera by surface structure and comparison with hantaan virus using negative stain electron microscopy.ultrastructural studies of glutaraldehyde-fixed viruses of the bunyaviridae were performed by negative-stain electron microscopy. the surface structure of viruses of each genus was compared with that of the other genera and with hantaan virus, the prototype of a proposed new genus of bunyaviridae. viruses of each genus had a surface structure distinct for that genus. in addition, hantaan virus had a surface structure composed of a grid-like pattern of morphologic subunits not previously describe ...19852412528
an immune adherence assay for discrimination between etiologic agents of hemorrhagic fever with renal syndrome.antigens of the viruses that cause hemorrhagic fever with renal syndrome (hfrs) and antibodies to these antigens were titrated in an immune adherence hemagglutination (iaha) test and a cf test. vero-e6 cells infected with the sr-11 strain of hfrs virus, an isolate from rats associated with a laboratory outbreak in japan, and the 76-118 strain of hantaan virus, the etiologic agent of korean hemorrhagic fever, were used as antigens in the iaha, cf, and indirect immunofluorescent antibody (ifa) tes ...19846141206
hfrs after a wild rodent bite in the haute-savoie--and risk of exposure to hantaan-like virus in a paris laboratory. 19846142362
antigenic comparison of virus strains of mild and classical types of epidemic haemorrhagic fever isolated in china and adaptation of these to cultures of normal cells. 19846142363
hfrs outbreak associated with laboratory rats in uk. 19846144891
[indirect hemagglutination test for indicating the hfrs virus and the laboratory diagnosis of the disease].conditions have first been developed for the preparation of erythrocyte immunoglobulin diagnostic preparation of erythrocyte immunoglobulin diagnostic preparation for hfrs virus which permits express detection of the specific virus antigen in suspensions of the lung tissue of rodents by means of the indirect hemagglutination test (iha) and laboratory diagnosis of the infection in humans by means of antibody detection by the indirect hemagglutination-inhibition test (ihai). the iha test is as sen ...19846143451
isolation of a virus related to hemorrhagic fever with renal syndrome from urban rats in a nonendemic area. 19846143783
[the diagnosis of hemorrhagic fever with renal syndrome using an indirect immunoenzyme histochemical method with horseradish peroxidase-labelled staphylococcus protein a]. 19846152605
determination by immune adherence ha of the antigenic relationship between rattus- and apodemus-borne viruses causing hemorrhagic fever with renal syndrome. 19846201565
isolation and propagation of nephropathia epidemica virus in bank voles.three strains of nephropathia epidemica (ne) virus were isolated from lung tissues of bank voles (clethrionomys glareolus) and a grey-sided vole (c. rufocanus) trapped in västerbotten county, sweden. two of these isolates were serially passaged in seronegative laboratory-bred bank voles. experimentally infected animals developed a subclinical infection characterized by virus persistence, particularly in lung tissue. attempts to infect other species of colonized rodents with ne virus and to isola ...19846208601
[studies on growth conditions of ehf virus in primary rat lung cell culture]. 19846241087
hantaan-like viruses from domestic rats captured in the united states.recent observations that rattus rodents in asia harbor hantaan (htn)-like viruses associated with hemorrhagic fever with renal syndrome led us to investigate the possibility that similar viruses might be present in the united states. wharf rats were captured at major port cities, their sera were examined for htn antibody by immunofluorescent antibody (ifa) assay and tissues from selected antibody-positive rats were examined for htn antigen. rats positive for both antibody and antigen to htn viru ...19846435464
infectivity titration of hemorrhagic fever with renal syndrome virus: use of immune adherence hemagglutination for detection of virus growth.serial dilutions of hemorrhagic fever with renal syndrome viruses were inoculated into vero-e6 cells in microplates. after 2 weeks of incubation, infected cells were disrupted by freezing and thawing, and virus antigens were detected by immune adherence hemagglutination. the infectivity titers of the virus as determined by this method were in close agreement with those obtained by the immunofluorescent antigen endpoint method. then, a neutralization method was established. japanese hemorrhagic f ...19846436305
[isolation of strains of the virus of hemorrhagic fever with renal syndrome in cell culture].four strains of hemorrhagic fever with renal syndrome (hfrs) virus were isolated from the lungs of cl. glareolus caught in natural foci of hfrs in the european ussr. preliminary experiments using enzyme-immunoassay (eia) established the appurtenance of hfrs antigen in lung suspensions to the "western" serotype. four strains were isolated in vero-e6 cell culture after several blind passages and identified as the "western" serotype of hfrs virus. one stram originally isolated in wistar rats and pa ...19846437079
evaluation of focus reduction neutralization test with peroxidase-antiperoxidase staining technique for hemorrhagic fever with renal syndrome virus.titers of hemorrhagic fever with renal syndrome virus were estimated by counting foci stained with peroxidase-antiperoxidase or by using immunofluorescence methods. foci stained with pap were clearer and easier to count. the peroxidase-antiperoxidase method showed a linear relationship between virus concentration and the number of foci. a focus-reduction neutralizing antibody test was performed with immune rat sera and sera from patients. again, the peroxidase-antiperoxidase method proved to be ...19846440908
isolation in vero-e6 cells of hanta virus from clethrionomys glareolus captured in the bashkiria area of the u.s.s.r. 19846442126
experimental infection in newborn mice and rats by hemorrhagic fever with renal syndrome (hfrs) virus.newborn mice and rats were inoculated intracerebrally (ic) or intraperitoneally (ip) with hantaan virus (76-118 strain) or hfrs-related virus (b-1 strain). the mortality and the influence on the increase of body weight in newborn mice were higher in the groups infected with the 76-118 strain than in the groups infected with the b-1 strain, while the b-1 strain was more virulent in rats than the 76-118 strain. virus isolation from rats inoculated with either strain was attempted 7 and 11 weeks af ...19846442757
serological evidence for hantaan-related virus in africa. 19846149414
antibodies to the hfrs virus in the human population of european rsfsr as detected by radioimmunoassay.natural immunity to the causative agent of hemorrhagic fever with renal syndrome (hfrs) has first been studied using radioimmunoassay (ria) in the human population of the bashkir assr with the highest incidence of this infection and of five other regions of the rsfsr with lower incidence of hfrs. the antigen was prepared as a suspension of lungs of rodent from natural hfrs foci and contained a high concentration of virus protein. 12,000 sera from the population of 6 areas of the rsfsr were exami ...19846141781
two cases of hemorrhagic fever with renal syndrome in northern greece.two cases of hemorrhagic fever with renal syndrome were diagnosed in woodcutters presumably exposed to wild rodents and their urine in a forest in northern greece. the disease was characterized by acute renal insufficiency without hemorrhagic manifestations. one patient required hemodialysis, but both recovered without sequelae and developed a fourfold increase in titer of antibody to hantaan virus, as determined by an immunofluorescence test. these are the first reported cases of hemorrhagic fe ...19846145743
[animal reservoirs of epidemic hemorrhagic fever--experimental studies and identification of the specificity of rat lung antigens. cooperative research group for epidemic hemorrhagic fever]. 19846242546
isolation of the nephropathia epidemica agent in sweden. 19846143925
propagation of nephropathia epidemica virus in cell culture. 19846143926
hantavirus disease. 19846146051
[prevalence of ectoparasites, endoparasites, bacteria and anti-hantaan virus antibodies in wild rats captured in harbor area of shimizu, japan]. 19846431033
[serological confirmation of cases of hemorrhagic fever with renal syndrome in byelorussia]. 19846147043
[survey on serum hemorrhagic fever-renal syndrome antibody in normal population of zhenjiang prefecture]. 19846147237
scottish case of haemorrhagic fever with renal syndrome. 19846149371
antigenic difference between viral strains causing classical and mild types of epidemic hemorrhagic fever with renal syndrome in china.the antigenic relationship between viral isolates from apodemus and rattus that appear to cause the classical and mild types of epidemic hemorrhagic fever (ehf) in china was studied by cross-immunofluorescence, cross-neutralization, immunofluorescence blocking tests, and cross-enzyme-linked immunosorbent assay (elisa). obvious antigenic diversity between the isolates was demonstrated by cross-neutralization, immunofluorescence blocking tests, and cross-elisa. antisera from patients with classica ...19846150062
[hantavirus infections in the netherlands]. 19846441122
hemagglutination-inhibiting antibody in hemorrhagic fever with renal syndrome.hemagglutination activity was demonstrated in a hantaan virus antigen prepared from infected suckling mouse brain by sucrose-acetone extraction. hemagglutination of goose erythrocytes was ph dependent and was optimal at ph 6.0-6.2. immunofluorescent and hemagglutination-inhibiting antibodies were significantly correlated in 80 human and 13 animal sera. hemagglutination-inhibiting antibody was present in some patients 20 years after the onset of hemorrhagic fever with renal syndrome. the hemagglu ...19846150063
haemorrhagic fever virus with renal syndrome in small rodents in czechoslovakia.the antigen of haemorrhagic fever with renal syndrome (hfrs) was detected in the lungs of the following free-living small rodents trapped in different localities in eastern slovakia: clethrionomys glareolus (2 positive samples of 7), apodemus flavicollis (1 sample of 24) and apodemus agrarius (7 positive samples of 66). the virus was first identified by indirect fluorescent antibody (fa) staining using human convalescent serum from a case of epidemic nephropathy (ne) of scandinavia. the lung sus ...19846151356
[natural foci of hemorrhagic fever with renal syndrome in jiangsu province]. 19846152406
[survey on the reservior for hemorrhagic fever-renal syndrome in yingshang county, anhui province]. 19846146404
nephropathia epidemica in norway: antigen and antibodies in rodent reservoirs and antibodies in selected human populations.nephropathia epidemica (ne) antigen was detected by ifat (indirect fluorescent antibody technique) in the lungs of 14 of 97 bank voles (clethrionomys glareolus) collected in three endemic areas. the distribution of antigen positive voles within an endemic location was scattered. antibodies to korean hemorrhagic fever (khf) virus antigens were detected by ifat in 12 of 14 ne antigen positive bank voles and in 15 of 83 that were antigen negative. ne antigen positive voles exhibited higher antibody ...19846146649
[an observation on the persistent period of specific antibodies in epidemic hemorrhagic fever patients' convalescent sera]. 19836426799
[detection of viral antigen in rodents' lung tissue and antibody in patients' sera in the epidemic hemorrhagic fever endemic area of xinye county, henan province]. 19836426800
monoclonal antibodies specific for hantaan virus.six hybridoma cell line producing monoclonal antibodies to hantaan virus were established by fusion of ns-1 mouse myeloma cells with spleen cells of mice immunized with hantaan virus strain 76-118. the specificity of these monoclonal antibodies was established by immunoblotting analysis and immunofluorescence. five of the clones reacted with antigens on the cell surface and in the cytoplasm, and one clone reacted with a determinant expressed only in the cytoplasm of the infected cells. two of th ...19836408643
[investigation on the epidemic hemorrhagic fever antigen in rodents captured in benxi city]. 19836411348
[morphology of epidemic hemorrhagic fever virus. i. electron microscopic observation of virus in human diploid cell line]. 19836414714
isolation of hemorrhagic fever with renal syndrome (hfrs) virus from a tumor specimen in a rat.a strain of hemorrhagic fever with renal syndrome (hfrs) virus was isolated in a cell culture from a tumor specimen in a rat kept in a medical institution in which there was a case of hfrs. positive immunofluorescent reaction with sera from hfrs patients was recognized at the second passage and the number of cells containing antigen increased in the third passage. this virus, named b-1 strain, was identified as the hfrs virus by immunofluorescent tests with sera from patients.19836146307
[virus--the causative agent of hemorrhagic fever with renal syndrome--a new representative of the family bunyaviridae].physicochemical characteristics (sedimentation coefficient, buoyant density of particles, as well as ribonuclein of these particles) and morphology of the causative agent of hemorrhagic fever with renal syndrome were found to be similar to those of the other members of the bunyaviridae family.19836412459
epidemic hemorrhagic fever with renal syndrome. a broadening horizon.a virus identical to or closely related to the viruses of the epidemic hemorrhagic fevers and/or nephropathia epidemica has been demonstrated serologically in rats from geographically separate areas of this country by three groups of investigators. this information suggests a previously unrecognized health threat that should be considered in the differential diagnosis of patients initially seen with febrile illnesses and acute renal failure. the salient features of these viral diseases and the c ...19836139987
[characteristics of the epizootic process of a natural foci of hemorrhagic fever with renal syndrome in small mammals trapped on the outskirts of ufa]. 19836136899
potential reservoir and vectors of haemorrhagic fever with renal syndrome (hfrs) in the u. s. s. r. 19836229222
[results and prospects of using immunologic methods in the study and diagnosis of hemorrhagic fever with renal syndrome]. 19836142546
[serologic examination of patients with hemorrhagic fever with renal syndrome in the european part of the ussr].certain features of humoral immunity in patients suffering from hemorrhagic fever with renal syndrome (hfrs) in the territory of the european ussr were established: a trend for increasing antibody levels for a long time after convalescence (approximately 6 months) and the lack of significant decline of antibody levels for many years (5-10). comparative clinico-serological studies revealed the occurrence of subclinical and atypical forms of hfrs disease.19836142566
features of circulation of hemorrhagic fever with renal syndrome (hfrs) virus among small mammals in the european u.s.s.r.the use of indirect fluorescent antibody testing (ifat) and enzyme linked immunosorbant assay (elisa) procedures allowed the hemorrhagic fever with renal syndrome (hfrs) virus antigen to be detected not only in the known reservoir host, clethrionomys glareolus, but also in 7 other species of small mammals in european foci of the u.s.s.r. marked viscerotropism of hfrs virus and the participation of brown fat in maintaining the infection in rodents were demonstrated. the frequency of detection of ...19836220688
[identification of hemorrhagic fever-renal syndrome virus isolated from different areas in china by immuno-enzyme electron microscopy--morphological study on various virulent strains]. 19836233018
detection of antibody against hemorrhagic fever with renal syndrome (hfrs) virus in sera of house rats captured in port areas of japan. 19836408289
[experimental animal information file: isolation of epidemic hemorrhagic fever virus]. 19836412637
[isolation of the virus of hemorrhagic fever with renal syndrome (hfrs) from the blood of patients using vero e-6 cell culture]. 19836416679
[detection of the viral antigen of hemorrhagic fever with renal syndrome in the lungs of a murine population and a sero-epidemiologic survey]. 19836416680
[detection of the viral antigen of hemorrhagic fever with renal syndrome (hfrs) in apodemus species]. 19836416681
an epidemiological survey of nephropathia epidemica in sweden.the indirect immunofluorescence test (ift) using the hantaan virus (agent of korean hemorrhagic fever, khf) was applied for detection of antibodies to nephropathia epidemica (ne). from 103 patients with symptoms suggesting ne, 61% revealed khf/ne antibodies in the convalescent sera. all seropositive patients seemed to have acquired their disease in ne endemic areas (north of the 60th parallel). only patients found to have a typical clinical ne (fever, abdominal pain and renal engagement) were se ...19836417769
analysis of hantaan virus rna: evidence for a new genus of bunyaviridae.hantaan virus, the prototype virus of hemorrhagic fever with renal syndrome, was examined for nucleic acid characteristics which would support its previously proposed inclusion in the virus family bunyaviridae. nucleocapsid rna from hantaan virions and a control bunyavirus were examined for ribonuclease a (rnase a) sensitivity. both viruses exhibited a similar accessibility of rna within nucleocapsids to digestion by rnase a. complete digestion of the rna of both viruses was affected with high c ...19836419460
[a preliminary observation on the antigen of epidemic hemorrhagic fever virus carried by rodents in linyi prefecture]. 19836202417
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