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[behavior of microsomal mannosyl-transferases in cells carrying an arbovirus infection]. 19724622409
[monocatenary ribonucleic acids of an arbovirus of group a: sindbis virus]. 19724622410
comparisons of togaviruses: sindbis virus (group a) and kunjin virus (group b). 19724625020
effects of ionic strength on the release of dengue virus from vero cells. 19724631144
[detection of antibodies to a series of arboviruses of groups a, b and bunyamwera on the territory of the georgian ssr]. 19724260426
a case of sindbis virus infection in kuala lumpur. 19724268041
structural and immunologic characteristics of subviral components of sindbis, eastern equine and western equine encephalitis viruses. 19724212354
influence of pure virus infection on wound healing. 19724366234
[polymyositis and virus]. 19724333473
unusual molecular size of rna from a long-rod mutant of vesicular stomatitis virus. 19724333570
effect of concanavalin a on cells infected with enveloped rna viruses. 19724334774
growth of newcastle disease and herpes virus and interferon production in a monkey-mouse hybrid line. 19724334778
inhibition of virus growth by ouabain: effect of ouabain on the growth of hvj in chick embryo cells.the effect of ouabain (g-strophanthin), a cardiac glycoside, on the growth of several enveloped viruses was examined. it was found that the growth of hvj (sendai virus) in chick embryo cells was markedly inhibited by the drug at a concentration as low as 5 x 10(-5)m. a virus-inhibitory concentration of ouabain did not cause morphological changes in uninfected cells, nor did it have the capacity to inactivate virus infectivity. ouabain interfered with the intracellular synthesis of viral macromol ...19724335518
general characteristics of enhanced plague formation by poliovirus in poxvirus-infected cells. 19724336518
inhibition of the multiplication of enveloped rna-viruses by glucosamine and 2-deoxy-d-glucose. 19724336520
evaluation of gentamicin for use in virology and tissue culture.data are presented comparing gentamicin to penicillin and streptomycin (pen-strep) in tissue culture medium with respect to a number of parameters associated with virology and tissue culture. unlike pen-strep, gentamicin was stable at ph 2 to 10 for 15 days at 37 c in tissue culture medium, and its activity was unaffected by the presence of serum. moreover, it was stable to autoclaving. twenty cell types replicated normally at the suggested concentration of 50 mug/ml, and all cells were unaffect ...19724336661
inhibition of cytomegalovirus by rifampin. 19724336860
selective association of sindbis virion proteins with different membrane fractions of infected cells.plasma and smooth membranes obtained from chicken embryo cells infected with sindbis virus were solubilized and subjected to electrophoresis on acrylamide gels. the electrophoretic patterns showed that (i) the major proteins synthesized and associated with plasma membranes from infected cells are virion proteins and (ii) at 4 hr after infection virion proteins are not present at detectable levels in the smooth membranes of the cell.19724337164
correlation of messenger rna function with adenylate-rich segments in the genomes of single-stranded rna viruses.oligonucleotides enriched in adenylate residues have been demonstrated in the genomes of two positive-strand rna viruses, sindbis and columbia sk. such oligonucleotides were not found in the genome of vesicular stomatitis virus, a negative-strand virus. the adenylate-rich oligonucleotides from sindbis and columbia sk viruses appeared similar when analyzed by zonal sedimentation in sucrose-sodium dodecyl sulfate.19724338595
production of crude human interferon with high specific activity. 19724338797
improved assays for a variety of interferons. 1. 19724341554
variations in interferon production by lymphocytes from patients with chronic lymphatic leukaemia.in a group of patients with chronic lymphatic leukaemia leucocyte cultures showed a diminished capacity to synthesize interferon when compared with controls. the leucocyte culture with the lowest capacity to synthesize interferon came from the patients with the highest peripheral blood lymphocyte counts and vice versa. these results are presented as indirect evidence that t lymphocytes are more competent producers of interferon than b lymphocytes.19724343746
a simple interferon assay as an adjunct for determining the genus of origin of cell cultures. 19724346259
some characteristics of lower molecular weight arbovirus rna's. 19724636723
[filiation relationship between specific ribonucleic acids of a group a togavirus]. 19724639773
heterogeneity in the poly(a) content of the genome of sindbis virus. 19724640690
effect of double-stranded rnas from sindbis virus-infected cells on rabbit reticulocyte and chick embryo cell-free protein synthesis. 19724641255
[classification and identification of arboviruses]. 19724642703
[replication intermediaries in ribonucleic acid synthesis of group a togavirus]. 19724655816
elimination of repeated clot formation in mouse ascitic fluid containing arbovirus antibodies.repeated clot formation in mouse ascitic fluids containing antiviral antibody was eliminated by acid precipitation of the fibrinogen.19724672320
specific membranous structures associated with the replication of group a arboviruses.intracytoplasmic membranous structures of a unique type were associated with the replication of three group a arboviruses: semliki forest virus (sfv), sindbis virus, or western equine encephalomyelitis virus. the structures, referred to as type 1 cytopathic vacuoles (cpv-1), were membrane-limited and characteristically lined by regular membranous spherules measuring 50 nm in diameter. the membranous spherules typically contained a fine central density, but were neither virus cores nor virions. d ...19724672392
morphology and morphogenesis of sindbis virus as seen with freeze-etching techniques.freeze-etch electron microscope studies of the morphogenesis and morphology of sindbis virus confirmed results obtained by other workers employing thin-sectioning techniques. the 68-nm virion was found to have a nucleocapsid 36 nm in diameter surrounded by a double-layered, unit membrane. the membranous envelope is acquired as the capsid buds through the plasma membrane of the infected cell. the freeze-etch technique also provided the following new information. (i) at any one time, budding occur ...19724672393
inhibition of sindbis virus release by media of low ionic strength: an electron microscope study.release of sindbis virus from infected cells is inhibited by lowering the ionic strength of the medium. to determine the nature of the inhibited step, we examined, by electron microscopy, both freeze-etched and thin-sectioned preparations which had been fixed with either glutaraldehyde or formaldehyde. inhibitory medium had two different effects on sindbis virus release: virus budding was partially inhibited, and those virions which did mature were precipitated on the surface of the cell. freeze ...19724672394
[low temperature thresholds of reproduction of group a arboviruses in tissue culture]. 19724672889
viral rna species in bhk-21 cells infected with sindbis virus serially passaged at high multiplicity of infection. 19724672930
formation of sindbis virus proteins: identification of a precursor for one of the envelope proteins.exposure of sindbis virus-infected chicken embryo cells to a short pulse of radioactive amino acids revealed the formation of primarily three proteins: the nucleocapsid (c) of the virus, one of the viral envelope proteins (e1), and a glycoprotein that did not appear in the virion. this third protein (pe2) has now been identified as a precursor of the other viral envelope protein (e2) on the basis of two observations: (i) the simultaneous disappearance of radioactive pe2 and appearance of labeled ...19724673887
demonstration of double-stranded ribonucleic acid in concentrates of rna viruses. 19724673907
replication of sindbis virus. i. relative size and genetic content of 26 s and 49 s rna. 19724675142
replication of sindbis virus. ii. multiple forms of double-stranded rna isolated from infected cells. 19724675143
studies of interferon production in aedes albopictus mosquito cells. 19734683227
[comparative study of the thermal inactivation of the hemagglutinating and infectious activity of the venezuelan equine encephalomyelitis virus]. 19734705385
response in measles antibodies of the guinea-pig treated with interferon inductors. 19734709856
interference mediated by a variant of sindbis virus. i. isolation of an avirulent variant and in vivo interference. 19734723081
rat interferons. i. biological properties of interferons in rat serum. 19734730814
chromatographic purification of the sindbis virus: comparison of different methods. 19734733054
altered pattern of viral rna synthesis in cells infected with standard and defective sindbis virus. 19734734328
protein synthesis directed by an rna temperature-sensitive mutant of sindbis virus.the structural proteins of wild-type sindbis virus were shown to arise by posttranslational cleavage of larger precursors. the proteins synthesized in wildtype infection were compared with those specified by ts-11, a temperature-sensitive mutant unable to synthesize viral rna at the restrictive temperature. abnormally large, virus-specific proteins were found in the mutant-infected cells after the shift from 28 c to 41.5 c. these large polypeptides were presumably precursors which were cleaved t ...19734734648
induction of an interferon-like substance in persistently infected aedes albopictus cells. 19734735533
agglutination of sindbis virus and of cells infected with sindbis virus by plant lectins.we have examined the agglutination of sindbis virus and of chick and hamster cells infected with sindbis virus by two of the plant lectins, concanavalin a and ricinus communis agglutinin. both lectins agglutinate the virus by binding to the polysaccharide chains of the envelope glycoproteins. both chick and hamster cells exhibit increased agglutination by the lectins after infection by sindbis virus. in the case of chick cells infected with sindbis virus, this increase in agglutinability occurs ...19734735591
homologous viral interference in aedes albopictus cultures chronically infected with sindbis virus.complete homologous interference is demonstrated in cultures of aedes albopictus cells chronically infected with sindbis virus. the interference occurred before there was any detectable rna synthesis by the superinfecting virus.19734735592
defective-interfering particles of sindbis virus. i. isolation and some chemical and biological properties. 19734735935
enzymatic iodination of sindbis virus proteins.sindbis virus was iodinated by using the enzyme lactoperoxidase, an iodination technique which labels only surface proteins. by this technique, the two viral glycoproteins are labeled, and the internal viral protein is not. the two glycoproteins are iodinated to strikingly different extents. this difference in susceptibility to iodination apparently is due to the position or conformation of the glycoproteins in the envelope spikes of the virion and not to differing contents of tyrosine, the amin ...19734736110
large-molecular-weight precursors of sindbis virus proteins.infection of chicken embryo fibroblasts with a temperature-sensitive mutant of sindbis virus at the nonpermissive temperature leads to the accumulation of a large-molecular-weight protein. we have shown that this protein contains (14)c-arginine tryptic peptides present in the three virion proteins. we have also found that a slightly smaller protein which is detected in sindbis-infected bhk cells contains the (14)c-arginine tryptic peptides of the two envelope proteins but not those of the capsid ...19734736531
a serological survey for viral antibodies in wild ducks. 19734736770
induction of interferon in perfused whole rat-lung cultures. 19734746917
age-dependent resistance of mice to sindbis virus infection: reticuloendothelial role. 19734762950
a survey for antibodies to arboviruses in domestic fowls in queensland. 19734777213
serologic examination of some domestic animals from south moravia on the presence of antibodies to selected arboviruses of the a, b, california and bunyamwera groups. 19734777760
large scale irrigation and arbovirus epidemiology, kano plain, kenya. ii. preliminary serological survey. 19734779116
surveys of haemagglutination-inhibiting antibody to arboviruses in aborigines and other population groups in northern and eastern australia, 1966-1971. 19734784056
serologic survey of kuwait population for evidence of group a arbovirus infection. 19734789151
[formation of active polynucleotide complexes on the surfaces of cells]. 19734789975
[polyribosomes and ribonucleic acids associated with polyribosomes in cells infected by a togavirus, the sindbis virus]. 19734791966
analysis of antigenic activities of enzymatically digested sindbis virus envelopes. 19734793409
proteins specified by sindbis virus in chick embryo fibroblast cells. 19734795358
defective-interfering particles of sindbis virus. ii. homologous interference. 19734795463
a more precise and sensitive hemagglutination reduction assay for interferon. 19734795518
lack of uptake of intact polyriboinosinic-polyribocytidylic acid by cells. 19734795764
system for studying uninfected and virus-infected cell cultures in hyperbaric chambers.equipment and techniques previously used to investigate the effect of hyperbaric gases on bacteria were modified to permit comparable investigations with uninfected and virus-infected tissue cell cultures. this report describes the modified equipment and related methodology. use of the system is illustrated with findings on the effect of oxygen-helium mixtures at 68 atm on cell physiology and virus growth in two cell types. our results suggested that, under those experimental conditions, several ...19734796161
biosynthesis of the sindbis virus carbohydrates.the sequence in which sugars are added to the sindbis virus glycoproteins was studied. infected cells contain three glycosylated virus-specific proteins: the two virion glycoproteins and the immediate precursor to the smaller virion glycoprotein. larger sindbis-specific proteins are not glycosylated. the cell-associated forms of both of the virion glycoproteins contain glucosamine, mannose, galactose, and fucose. the glycosylated precursor contains only glucosamine, mannose, and some galactose. ...19734796898
defective interfering passages of sindbis virus: chemical composition, biological activity, and mode of interference.defective interfering (di) particles of sindbis virus, appearing between the eighth and fourteenth passages, cosediment with and have the same buoyant density as standard virus. virion rna from such late passages is heterogeneous by polyacrylamide gel electrophoresis, whereas early passage rna is homogeneous. no differences were found in the virion proteins from such passages. cells co-infected with early and late passage virus synthesize as much intracellular viral-specific rna and protein as i ...19734798187
relation between ionic coupling and morphology of established cells in culture. 19734798836
[the biophysical characteristics of viral structures in chronic sindbis infection]. 19734799466
[the relationship between the induction of interferon synthesis by a heat sensitive sindbis virus mutant and the quantity of virus specific rna in the chicken fibroblast culture]. 19734799467
[identification of specific ribonucleic acids of the sindbis virus bound to different fractions of the endoplasmic reticulum]. 19734803140
[african zoonoses caused by viruses]. 19734346544
electron microscopic study of sindbis virus morphogenesis. 19734348164
viral interference with exoerythrocytic forms of malaria (plasmodium gallinaceum) in ovo. 19734353044
interference mediated by a variant of sindbis virus. ii. actinomycin d-sensitive interference in the absence of interferon. 19734353045
the cell surface membrane: biochemical aspects and biophysical probes. 19734354315
isolation and characterization of virus-resistant mouse embryo fibroblasts. 19734355331
heterologous activity of monkey interferons. 19734355757
persistent infection of mouse cells with sindbis virus: role of virulence of strains, auto-interfering particles and interferon. 19734356681
inhibition of hog cholera virus by acriflavine. a property shared with bovine virus diarrhoea virus. brief report. 19734356773
characterisation of the 3'-terminus of sindbis virion rna. 19734357110
a novel substituted guanidine with high activity in vitro against rhinoviruses. 19734357165
the effect of frog virus 3 on the biological activity of various rna viruses. 19734357374
on the receptor of influenza viruses. 1. artificial receptor for influenza virus. 19734358675
role of incomplete viruses and interferon in persistent infection of mouse cells with sindbis virus. 19734358717
studies on antiviral activity of alpha-trihalogenomethylamines. 19734358719
[inhibition of multiplication of rna-containing viruses in tissue culture by combined use of an interferon inducer and ribonuclease]. 19734359363
new isothiazole derivatives. ii. cytotoxicity and antiviral activity in tissue cultures. 19734361627
[the effect of nucleases on the reproduction of rna- and dna-containing viruses]. 19734363590
[changes in the properties of sindbis virus during passage experiments in "drosophila" (author's transl)]. 19734214134
viral rnas associated with ribosomes in sindbis virus-infected hela cells.virus specific rna ribosome complexes were isolated by sucrose density gradient centrifugation of cytoplasmic extracts from hela cells infected at 42 c with an rna(+) mutant (ts2) of sindbis virus. viral rna-ribosome complexes were accumulated by infected cells treated with sodium fluoride and cycloheximide. the rna-ribosome complexes were characterized by (i) their sensitivity to the action of ribonuclease or ethylenediaminetetraacetic acid, (ii) their density in cesium chloride gradients, and ...19734632442
identification of polysomal rna in bhk cells infected by sindbis virus.polysomes were prepared from sindbis virus-infected bhk cells. the major species of rna in these polysomes was identified as 26s rna (interjacent rna) by (i) disrupting the polysomes with edta; (ii) treating the infected cells with puromycin; and (iii) isolating polysomes from cells infected with a temperature-sensitive mutant that does not form nucleocapsids. small amounts of 42s rna and 33s rna were also found in polysomes.19734633684
[interaction of virus and lysosome (author's transl)]. 19734596204
japanese quail embryo cells as a host of group a arboviruses. 19734541936
cellular immune response to viral infection: in vitro studies of lymphocytes from mice infected with sindbis virus. 19734543313
virological and immunofluorescent studies on the multiplication of sindbis virus in l cells. 19734583661
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